                         SEQUENCE LISTING

<110>  Akesion GmbH
 
<120>  Rekombinantes Fusionsproteine zur Vorbeugung oder Behandlung von 
       Adhsionen bei Geweben oder Organen.

<130>  AK01

<150>  DE102014112212.7
<151>  2014-08-26

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1509
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion zwischen Ancrod und des humanen Fc IgG1 Antikrpers

<400>  1
gcggccgcca ccatgaaatg ggtcaccttt atctcccttc tgttcctctt tagtagcgcc       60

tattctgtca tcggtggtga cgagtgcaat atcaacgagc atcgatttct ggtggcagtg      120

tatgaaggaa ccaactggac ctttatctgc ggcggggtcc ttattcaccc agagtgggtc      180

attaccgccg aacactgtgc tcggcgtcga atgaatcttg tgttcgggat gcacaggaaa      240

tcagagaagt ttgatgacga acaggaacgg tatcccaaga agcggtactt cattcgatgc      300

aacaaaaccc ggactagctg ggatgaggac atcatgctga ttcggctgaa caagcccgtg      360

aataacagcg agcatattgc tcctttgtca ctgccttcca atccgcctat tgtgggtagt      420

gactgccgtg tgatgggctg gggtagcatt aacagaagga tccacgtgct tagcgatgaa      480

cccagatgtg ccaacatcaa tctccacaac ttcaccatgt gtcatgggtt gttccgcaag      540

atgcctaaga agggacgcgt actctgtgct ggcgatctgc gcggtagacg ggactcttgc      600

aattcagata gtggaggacc ccttatctgc aacgaagagc tgcatggcat tgtggccaga      660

ggccccaatc catgtgcaca gcccaacaaa ccagctctgt atactagcgt gtacgactac      720

agggattggg tgaacaacgt tatcgccggc aatgcaacct gtagtccagg cggcggcgga      780

gccggtggag gcggggcagg aggaggagga gctagagaca aaacacacac ttgtccaccc      840

tgtcctgctc ccgaactgct tggtggaccc agcgtgtttc tgtttccgcc taagcccaaa      900

gacaccctca tgatctcacg gactcccgaa gttacgtgtg tcgtagtaga cgtgtcacac      960

gaagatcccg aggtcaagtt caactggtat gtggacggag ttgaggttca caacgccaaa     1020

accaaaccga gagaggagca gtacaactcc acatataggg tggtaagcgt gttgaccgtg     1080

ctgcatcagg attggctgaa tggcaaagag tacaagtgca aggtgtccaa taaggctctt     1140

ccagcaccca ttgagaaaac gatctccaag gcgaaaggcc aacctcgtga acctcaggtg     1200

tatactctcc ctccaagtcg cgatgagctc accaagaacc aggtgtcttt gacatgcctc     1260

gtcaaagggt tctacccatc agacatagcc gtcgaatggg agtctaatgg ccaaccagag     1320

aataactaca agaccactcc tccggttctg gatagtgatg ggagcttctt tctgtacagc     1380

aagctgacag tcgacaagtc ccgatggcag cagggtaatg tgttcagttg ctctgtgatg     1440

catgaagccc tgcataacca ctatacccag aaaagcctgt ctctgagccc aggaaagtaa     1500

tagaagctt                                                             1509


<210>  2
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion zwischen Ancrod und des humanen Fc IgG1 Antikrpers

<400>  2

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Val Ile Gly Gly Asp Glu Cys Asn Ile Asn Glu His Arg Phe 
            20                  25                  30          


Leu Val Ala Val Tyr Glu Gly Thr Asn Trp Thr Phe Ile Cys Gly Gly 
        35                  40                  45              


Val Leu Ile His Pro Glu Trp Val Ile Thr Ala Glu His Cys Ala Arg 
    50                  55                  60                  


Arg Arg Met Asn Leu Val Phe Gly Met His Arg Lys Ser Glu Lys Phe 
65                  70                  75                  80  


Asp Asp Glu Gln Glu Arg Tyr Pro Lys Lys Arg Tyr Phe Ile Arg Cys 
                85                  90                  95      


Asn Lys Thr Arg Thr Ser Trp Asp Glu Asp Ile Met Leu Ile Arg Leu 
            100                 105                 110         


Asn Lys Pro Val Asn Asn Ser Glu His Ile Ala Pro Leu Ser Leu Pro 
        115                 120                 125             


Ser Asn Pro Pro Ile Val Gly Ser Asp Cys Arg Val Met Gly Trp Gly 
    130                 135                 140                 


Ser Ile Asn Arg Arg Ile His Val Leu Ser Asp Glu Pro Arg Cys Ala 
145                 150                 155                 160 


Asn Ile Asn Leu His Asn Phe Thr Met Cys His Gly Leu Phe Arg Lys 
                165                 170                 175     


Met Pro Lys Lys Gly Arg Val Leu Cys Ala Gly Asp Leu Arg Gly Arg 
            180                 185                 190         


Arg Asp Ser Cys Asn Ser Asp Ser Gly Gly Pro Leu Ile Cys Asn Glu 
        195                 200                 205             


Glu Leu His Gly Ile Val Ala Arg Gly Pro Asn Pro Cys Ala Gln Pro 
    210                 215                 220                 


Asn Lys Pro Ala Leu Tyr Thr Ser Val Tyr Asp Tyr Arg Asp Trp Val 
225                 230                 235                 240 


Asn Asn Val Ile Ala Gly Asn Ala Thr Cys Ser Pro Gly Gly Gly Gly 
                245                 250                 255     


Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Arg Asp Lys Thr His 
            260                 265                 270         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
305                 310                 315                 320 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495 


<210>  3
<211>  2618
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion zwischen Ancrod und humanem Serumalbumin

<400>  3
gcggccgctc tagagccacc atgaaatggg ttaccttcat tagcctcctg ttcctgtttt       60

cctccgccta ttctgttatc ggtggtgacg agtgtaacat caacgagcat aggttcctgg      120

tcgcagtgta tgagggcaca aactggacct tcatttgtgg cggggtgctg attcacccag      180

agtgggtaat aacagcggag cattgtgccc gcagacgcat gaatctcgtg tttggaatgc      240

atcgcaaaag cgagaaattc gatgatgaac aagaaaggta ccctaagaag cggtacttca      300

ttcggtgcaa caagacaaga acttcatggg acgaggacat catgctgatc cgtcttaaca      360

agccggtaaa taacagcgag catatcgcac cactctcatt gcccagcaac cctcccatcg      420

tgggaagcga ttgcagagtg atggggtggg gctccatcaa tagaaggatt cacgtgctct      480

ctgatgaacc gcggtgtgcc aacattaatc tgcataattt tactatgtgc catggtctgt      540

ttcgcaaaat gcccaagaaa ggaagagttc tgtgtgcagg cgatctgaga ggaaggagag      600

actcttgcaa ctccgatagt ggcgggccac tgatatgcaa cgaagagctt cacggaatcg      660

tggccagagg tcctaatcca tgtgctcagc ctaacaagcc cgctctgtac accagcgttt      720

atgactaccg ggattgggtc aacaatgtca ttgccggaaa tgccacctgt tcccctggcg      780

gcggcgggtc aggaggagga gggtctggtg gcggcgggtc tgacgcacat aaaagcgaag      840

tggctcaccg gtttaaagat ctcggcgaag agaacttcaa agctcttgta ttgattgcct      900

tcgctcagta cttgcaacag tgccctttcg aggaccacgt gaaactggtg aatgaagtca      960

cagaattcgc taagacgtgt gtggcggatg agagtgctga gaactgtgac aagagtctgc     1020

acaccctgtt tggggataaa ctgtgcactg tcgctactct gcgagaaact tatggcgaaa     1080

tggccgactg ctgcgccaag caggaacccg agagaaatga atgctttctg cagcacaaag     1140

acgacaaccc taatctgcca cgattggttc ggcccgaggt ggacgtaatg tgcacggctt     1200

tccacgacaa tgaggaaacc ttcctgaaga agtatctcta cgaaatagct cgacggcatc     1260

cctactttta tgcacccgag ctgctgttct ttgcgaagcg ctataaggcc gctttcacag     1320

aatgctgtca agctgccgac aaggctgcct gtctcctccc aaaactggac gagctccgcg     1380

atgaggggaa ggcaagcagt gccaaacagc gcctgaaatg cgcatcactt cagaaattcg     1440

gagagcgcgc attcaaagca tgggcagtgg ctcgattgtc ccagcgattt cctaaggctg     1500

aatttgccga agtgtcaaag ctggtgacag accttaccaa agtccacaca gaatgctgcc     1560

atggtgactt gctggagtgc gccgatgaca gagccgatct ggccaagtac atctgtgaaa     1620

atcaggattc catctcctcc aaactgaaag aatgctgcga gaaacccctg ctggagaaga     1680

gccattgtat tgctgaggtg gaaaacgatg agatgccagc ggacctccca tcactggcag     1740

ccgacttcgt cgagagtaag gacgtgtgta agaactacgc cgaagcgaag gatgtgtttc     1800

tcgggatgtt tctgtacgaa tatgcgcgtc gtcatcccga ttatagcgtg gttctgctgc     1860

ttaggcttgc caagacttac gaaaccaccc tcgagaagtg ttgtgccgcc gctgacccgc     1920

atgagtgcta cgccaaagta tttgacgagt ttaagcctct ggtcgaggag cctcagaacc     1980

tgatcaaaca gaactgcgag cttttcgagc agttgggtga atacaaattt cagaatgccc     2040

tgctcgtcag gtatactaag aaggtgcccc aagtgtctac acctaccttg gttgaggtca     2100

gccggaatct cggcaaggtc ggcagcaaat gctgtaagca cccagaggca aagcgtatgc     2160

catgtgcaga ggattatctg agtgtcgtcc tcaaccagct gtgcgtactt cacgaaaaga     2220

caccagtgtc cgatagggtc actaaatgtt gcaccgaatc tctggtgaat cggaggccct     2280

gtttctcagc tctggaagtt gatgaaacct acgttccgaa ggagttcaat gcagaaacgt     2340

ttacctttca cgctgacatc tgcacgctct ctgagaagga gaggcagata aagaagcaaa     2400

cagccctggt agagctggtt aaacacaagc ccaaagcaac aaaggagcag ctgaaagcgg     2460

tgatggatga cttcgccgcg tttgtggaga agtgctgtaa ggccgacgat aaagaaactt     2520

gcttcgccga agagggaaag aagcttgtgg cagctagcca agcagccctt gggttgcacc     2580

accatcacca ccactaatag ccactgtgct ggttcgaa                             2618


<210>  4
<211>  858
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion zwischen Ancrod und humanem Serumalbumin

<400>  4

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Val Ile Gly Gly Asp Glu Cys Asn Ile Asn Glu His Arg Phe 
            20                  25                  30          


Leu Val Ala Val Tyr Glu Gly Thr Asn Trp Thr Phe Ile Cys Gly Gly 
        35                  40                  45              


Val Leu Ile His Pro Glu Trp Val Ile Thr Ala Glu His Cys Ala Arg 
    50                  55                  60                  


Arg Arg Met Asn Leu Val Phe Gly Met His Arg Lys Ser Glu Lys Phe 
65                  70                  75                  80  


Asp Asp Glu Gln Glu Arg Tyr Pro Lys Lys Arg Tyr Phe Ile Arg Cys 
                85                  90                  95      


Asn Lys Thr Arg Thr Ser Trp Asp Glu Asp Ile Met Leu Ile Arg Leu 
            100                 105                 110         


Asn Lys Pro Val Asn Asn Ser Glu His Ile Ala Pro Leu Ser Leu Pro 
        115                 120                 125             


Ser Asn Pro Pro Ile Val Gly Ser Asp Cys Arg Val Met Gly Trp Gly 
    130                 135                 140                 


Ser Ile Asn Arg Arg Ile His Val Leu Ser Asp Glu Pro Arg Cys Ala 
145                 150                 155                 160 


Asn Ile Asn Leu His Asn Phe Thr Met Cys His Gly Leu Phe Arg Lys 
                165                 170                 175     


Met Pro Lys Lys Gly Arg Val Leu Cys Ala Gly Asp Leu Arg Gly Arg 
            180                 185                 190         


Arg Asp Ser Cys Asn Ser Asp Ser Gly Gly Pro Leu Ile Cys Asn Glu 
        195                 200                 205             


Glu Leu His Gly Ile Val Ala Arg Gly Pro Asn Pro Cys Ala Gln Pro 
    210                 215                 220                 


Asn Lys Pro Ala Leu Tyr Thr Ser Val Tyr Asp Tyr Arg Asp Trp Val 
225                 230                 235                 240 


Asn Asn Val Ile Ala Gly Asn Ala Thr Cys Ser Pro Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ala His Lys Ser 
            260                 265                 270         


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        275                 280                 285             


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu 
    290                 295                 300                 


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
305                 310                 315                 320 


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                325                 330                 335     


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            340                 345                 350         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        355                 360                 365             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    370                 375                 380                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
385                 390                 395                 400 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                405                 410                 415     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            420                 425                 430         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        435                 440                 445             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    450                 455                 460                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
465                 470                 475                 480 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                485                 490                 495     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            500                 505                 510         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        515                 520                 525             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    530                 535                 540                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
545                 550                 555                 560 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                565                 570                 575     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            580                 585                 590         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        595                 600                 605             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    610                 615                 620                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
625                 630                 635                 640 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                645                 650                 655     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            660                 665                 670         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        675                 680                 685             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    690                 695                 700                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
705                 710                 715                 720 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                725                 730                 735     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            740                 745                 750         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        755                 760                 765             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    770                 775                 780                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
785                 790                 795                 800 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                805                 810                 815     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            820                 825                 830         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        835                 840                 845             


Ala Leu Gly Leu His His His His His His 
    850                 855             


