                         SEQUENCE LISTING

<110>  THE TEXAS A&M UNIVERSITY SYSTEM
       GLOBAL BIODIAGNOSTICS CORP.
       CIRILLO, Jeffrey D.
 
<120>  BETA LACTAMASE AS BIOMARKER FOR THE SPECIFIC DETECTION OF 
       TUBERCULOSIS-COMPLEX

<130>  TAMUS-1-54434

<140>  PCT/US2015/______
<141>  2015-08-17

<150>  62/038,736
<151>  2014-08-18

<150>  62/134,332
<151>  2015-03-17

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  924
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  1
atgcgcaaca gaggattcgg tcgtcgcgaa ctgctggtag cgatggcaat gctggtttcc       60

gtgacggggt gtgcacggca tgcgagcggg gcccgtccgg catcgacaac cttgccggcc      120

ggagcggatc tggcggatcg cttcgccgag ctggagcgca gatacgatgc ccggcttggg      180

gtgtatgtgc ccgccaccgg caccaccgcc gcgatcgaat accgcgccga tgagcggttc      240

gcattctgct ccacgttcaa ggcgccgctc gtggcggcgg tgctgcacca aaacccgctc      300

acgcatctgg acaaactgat cacctacacc agtgacgaca ttcggtcgat ctccccggtg      360

gcccaacaac acgttcagac cgggatgacg atcgggcagc tttgcgatgc ggcgatacgc      420

tatagcgacg gcaccgccgc caacctgttg ctggccgatc ttggcggtcc cgggggcggc      480

accgcggcat ttaccggcta cctccgcagc ttgggtgaca ccgtgagccg gttggacgcc      540

gaggaaccgg agttgaaccg cgatccgccc ggggacgaac gggataccac aacaccgcac      600

gccatcgccc tggtgttgca gcagcttgtt ctcggcaacg cgttgccgcc cgacaagcgg      660

gcactgctca ccgattggat ggcgcgcaac accaccggag ccaagcggat ccgagcgggc      720

tttcccgccg attggaaggt gatcgacaag accgggaccg gtgactacgg acgagcaaac      780

gacatcgcgg tcgtgtggtc accgaccggc gtgccctacg tggtggccgt catgtccgat      840

cgtgccggcg gcgggtatga cgccgagccc cgtgaggcgc tgctcgccga ggcggcgacg      900

tgcgttgccg gtgtgcttgc atag                                             924


<210>  2
<211>  307
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  2

Met Arg Asn Arg Gly Phe Gly Arg Arg Glu Leu Leu Val Ala Met Ala 
1               5                   10                  15      


Met Leu Val Ser Val Thr Gly Cys Ala Arg His Ala Ser Gly Ala Arg 
            20                  25                  30          


Pro Ala Ser Thr Thr Leu Pro Ala Gly Ala Asp Leu Ala Asp Arg Phe 
        35                  40                  45              


Ala Glu Leu Glu Arg Arg Tyr Asp Ala Arg Leu Gly Val Tyr Val Pro 
    50                  55                  60                  


Ala Thr Gly Thr Thr Ala Ala Ile Glu Tyr Arg Ala Asp Glu Arg Phe 
65                  70                  75                  80  


Ala Phe Cys Ser Thr Phe Lys Ala Pro Leu Val Ala Ala Val Leu His 
                85                  90                  95      


Gln Asn Pro Leu Thr His Leu Asp Lys Leu Ile Thr Tyr Thr Ser Asp 
            100                 105                 110         


Asp Ile Arg Ser Ile Ser Pro Val Ala Gln Gln His Val Gln Thr Gly 
        115                 120                 125             


Met Thr Ile Gly Gln Leu Cys Asp Ala Ala Ile Arg Tyr Ser Asp Gly 
    130                 135                 140                 


Thr Ala Ala Asn Leu Leu Leu Ala Asp Leu Gly Gly Pro Gly Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Phe Thr Gly Tyr Leu Arg Ser Leu Gly Asp Thr Val Ser 
                165                 170                 175     


Arg Leu Asp Ala Glu Glu Pro Glu Leu Asn Arg Asp Pro Pro Gly Asp 
            180                 185                 190         


Glu Arg Asp Thr Thr Thr Pro His Ala Ile Ala Leu Val Leu Gln Gln 
        195                 200                 205             


Leu Val Leu Gly Asn Ala Leu Pro Pro Asp Lys Arg Ala Leu Leu Thr 
    210                 215                 220                 


Asp Trp Met Ala Arg Asn Thr Thr Gly Ala Lys Arg Ile Arg Ala Gly 
225                 230                 235                 240 


Phe Pro Ala Asp Trp Lys Val Ile Asp Lys Thr Gly Thr Gly Asp Tyr 
                245                 250                 255     


Gly Arg Ala Asn Asp Ile Ala Val Val Trp Ser Pro Thr Gly Val Pro 
            260                 265                 270         


Tyr Val Val Ala Val Met Ser Asp Arg Ala Gly Gly Gly Tyr Asp Ala 
        275                 280                 285             


Glu Pro Arg Glu Ala Leu Leu Ala Glu Ala Ala Thr Cys Val Ala Gly 
    290                 295                 300                 


Val Leu Ala 
305         


<210>  3
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  3
ttgccgagaa caagctgctg caacacca                                          28


<210>  4
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  4
tttgtccaga tgcgtgagcg ggttttggt                                         29


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  5
ttgccgagaa caagctgctg caacacca                                          28


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  6
atcagtttgt ccagatgcgt gagcgggttt t                                      31


<210>  7
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  7
cgcgatccca gtgacgacat tcggtgatcg cg                                     32


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  8
cgcgatcgct cacgcatctg gacaagatcg cg                                     32


<210>  9
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  9
cgcgatcctc acgcatctgg acaaacgatc gcg                                    33


<210>  10
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  10
cgcgatccaa aacccgctca cgcatgatcg cg                                     32


<210>  11
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide probe

<400>  11
cgcgatcgaa caagctgctg caacagatcg c                                      31


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  12
gacgaacggg ataccacaac                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  13
cattctgctc cacgttcaag                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  14
cgaacgggat accacaaca                                                    19


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  15
cattctgctc cacgttcaag g                                                 21


<210>  16
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  16
catctggaca a                                                            11


<210>  17
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  17
ttcgcattct g                                                            11


<210>  18
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  18
tcgcattctg                                                              10


<210>  19
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  19
ttcgcattct g                                                            11


<210>  20
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  20
ataccacaac a                                                            11


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  21
atccaatcgg tgagcagtgc                                                   20


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  22
atcgaccgaa tgtcgtcac                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  23
atccaatcgg tgagcagtgc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  24
tcgaccgaat gtcgtcactg                                                   20


<210>  25
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  25
atagcgtatc g                                                            11


<210>  26
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  26
actggtgtag g                                                            11


<210>  27
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  27
tgtcgtcact                                                              10


<210>  28
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  28
actggtgtag g                                                            11


<210>  29
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  29
gccatccaat                                                              10


<210>  30
<211>  1521
<212>  DNA
<213>  Mycobacterium smegmatis

<400>  30
atgtcagccg gttcggcacc gctcgtaacg ccacggcgga aaaacgcgct gcacgccgcc       60

accgcgtcac gcacggcgcg ctaccgtcga ccggtgaggc tgtcccggtc gcgcgtgccg      120

cggctctgcg ccatcggtgc tgttttcgcc gtggtggccg cgacatcgtg cagccggccc      180

gcacccgcgc ctcgtgaacc ggccccggcg accggcattg ccgccgcctc cccggccccg      240

accgcgcccc cgacgcaggt gacccagccc gtgaccccga cgggtgactt ctcggcggtc      300

acccggctcg tcgacgacgc cgtcgccgca cgccggctgc ccggtgcggt ggtccagatc      360

gggcacgcgg gcaagatcgt gttccgcgcg gcgttcggtg cgcgcaagct cgacggcgaa      420

ccgggcctgg acggttcccc gtcacccgcc gaaccgatga ccgaggacac cctgttcgac      480

ctggcgtccc tgacgaagag catcgcgacg acgacggccg tcctgcagct ctacgagcag      540

ggcaagatcc gcctcgacga gcccgtgcag acgtacctgc cggacttcaa ccccaccggc      600

gatccgcgcc gtgcccgggt gacgttgcgc atgttgctca cccacacatc gggtatcgcg      660

ggcgatctga gcctcgacgg gccgtggggg ctgaccgcgg ccgacaaggc cgagggcgtc      720

aagcgtgcgc tggccgcgtg ggtggtgttc gagcccggcg cgatgttcca ctactccgat      780

atcgggttca tcattctggg caccctggtc gagaagatca ccggacaatc cctggacggc      840

tacgtgcgcg agcatgtgtt cgcaccgctc ggcatgtccg acacgtacta cctgcccgcc      900

gcgaacgcgt gcggaccgca cgagatacgc ggcaacgcac tggtttccga tccggacgga      960

ccgcggacga ccgactgccc ggccgattcc tggagcacgg gcctgctgac ccgggtcgcc     1020

cccaccgcgc tcgacgagga caccccgggc atcaacccgc atttcgggct gcccctgcgc     1080

ggaaccgtgc acgacccgac ggcacgccgc atgggcgggg tggccggaag cgcgggcgtg     1140

ttcacgacgg ttcacgacct gggcctgttc gcgcaggcgt tgctcgaccg acgggccaac     1200

cgccccagca cttttccgct gcagcaggcg acggtcgaac tgatgaccac accacagcag     1260

cccggcgccg gaccagatct gcgtggtctg ggctgggaca tcgacacgcc gcactcgcga     1320

ccacgcggca cggtgttccc ggtcggcagc ttcggccaca ccgggttcac cggggtctcg     1380

atgtggatgg accctggatc ggacacctac gtgatcgtcc tggcgaacgt catccatcag     1440

cgcggcggcc cgccgatcgc gacgctcagc ggtgacgtgg ccaccgaggc cgcgcgtgcg     1500

ctgcaccttt acgggacttg a                                               1521


<210>  31
<211>  401
<212>  PRT
<213>  Mycobacterium smegmatis

<400>  31

Met Asn Leu Asp Ala Asn Gln Ala Asp Ile Arg Glu Val Cys Asp Ala 
1               5                   10                  15      


Gly Leu Leu Ser Gly Ala Val Thr Val Val Trp Gln His Gly Glu Val 
            20                  25                  30          


Leu Gln Val Asn Glu Ile Gly Tyr Arg Asp Val Glu Ala Gly Leu Pro 
        35                  40                  45              


Met Gln Arg Asp Thr Leu Phe Arg Ile Ala Ser Met Thr Lys Pro Val 
    50                  55                  60                  


Thr Val Ala Ala Ala Met Ser Met Val Asp Glu Gly Lys Met Ala Leu 
65                  70                  75                  80  


Arg Asp Pro Ile Thr Arg Trp Ala Pro Glu Leu Arg Asp Ile Arg Val 
                85                  90                  95      


Leu Asp Asp Pro His Gly Pro Leu Asp Arg Thr His Pro Thr Arg Arg 
            100                 105                 110         


Pro Ile Leu Ile Glu Asp Leu Leu Thr His Thr Ser Gly Leu Ala Tyr 
        115                 120                 125             


Ser Phe Ser Val Ser Gly Asp Ile Ser Arg Ala Tyr Met Arg Leu Pro 
    130                 135                 140                 


Phe Gly His Gly Ser Asp Ala Trp Leu Ala Glu Leu Ala Ala Leu Pro 
145                 150                 155                 160 


Leu Val His Gln Pro Gly Glu Arg Val Thr Tyr Ser His Ala Ile Asp 
                165                 170                 175     


Leu Leu Gly Val Ile Met Ser Arg Ile Asp Asp Lys Pro Phe Tyr Gln 
            180                 185                 190         


Val Leu Asp Glu Arg Ile Leu Gly Pro Ala Gly Met Thr Asp Thr Gly 
        195                 200                 205             


Phe Phe Val Ser Thr Gln Ala Gln Arg Arg Ala Ala Thr Met Tyr Arg 
    210                 215                 220                 


Leu Asp Glu Leu Asp Gln Leu Arg His Asp Val Met Gly Pro Pro His 
225                 230                 235                 240 


Val Arg Pro Pro Ser Phe Cys Asn Ala Gly Gly Gly Leu Trp Ser Thr 
                245                 250                 255     


Ala Asp Asp Tyr Leu Arg Phe Val Arg Leu Leu Leu Gly Asp Gly Thr 
            260                 265                 270         


Ile Asp Gly Val Arg Val Leu Ser Pro Glu Ser Val Arg Leu Met Arg 
        275                 280                 285             


Thr Asp Arg Leu Ser Asp Glu His Lys Arg His Asn Phe Leu Gly Ala 
    290                 295                 300                 


Pro Phe Trp Val Gly Arg Gly Phe Gly Leu Asn Leu Ser Val Val Thr 
305                 310                 315                 320 


Asp Pro Ala Gln Ser Thr Pro Leu Phe Gly Pro Gly Gly Leu Gly Thr 
                325                 330                 335     


Phe Ser Trp Pro Gly Ala Tyr Gly Thr Trp Trp Gln Ala Asp Pro Gly 
            340                 345                 350         


Ala Asp Leu Ile Leu Leu Tyr Leu Ile Gln His Cys Pro Asp Leu Ser 
        355                 360                 365             


Val Asn Ala Ala Ala Ala Val Ala Gly Asn Pro Gly Leu Ala Lys Leu 
    370                 375                 380                 


Arg Thr Ala Gln Pro Arg Phe Val Arg Arg Thr Tyr Arg Ala Leu Gly 
385                 390                 395                 400 


Leu 
    


<210>  32
<211>  1201
<212>  DNA
<213>  Mycobacterium marinum

<400>  32
gtgaatctcg acgccaacca ggctgatatc cgcgaggtct ccggattgct ctccggcgca       60

gtgaccgtgg tttggcagca cggagaagta ctgcaggtca acgaaatcgg ctaccgagac      120

gtcgaggcgg gcctgccgat gcagcgcgac acgctgtttc gcatcgcgtc catgaccaaa      180

cccgtcaccg ttgccgcggc catgagcatg gtcgacgagg gcaaaatggc cctgcgtgac      240

ccgatcacac gctgggcgcc cgagttgcgc gacatccggg tgcttgacga cccgcacggc      300

ccgttggacc gcacgcaccc cacccgacgg ccgatcctca tcgaggacct gctgacccac      360

accagcgggc tggcctacag tttttcggtg tccggagaca tttcgcgggc gtacatgcga      420

ttgccatttg gtcatggttc cgacgcctgg ctggccgaac tcgccgcgct gccactggtg      480

caccagcccg gcgagcgggt cacctacagc cacgccatcg atctgctcgg cgtcatcatg      540

tcccgcatcg acgacaagcc tttctaccag gtgctcgacg agcgaatact gggcccggcc      600

ggcatgaccg acaccggctt cttcgtgtcg acacaggccc agcgccgcgc cgcaaccatg      660

taccgcctcg acgagctgga ccagctacgg cacgacgtca tgggcccgcc gcacgtgcgg      720

cctccgtcgt tctgcaacgc cggcggcgga ttgtggtcaa ccgccgacga ctacctgaga      780

tttgtccggc tactgctcgg cgacgggacg atcgacggcg ttcgggtgct ctcaccggag      840

tcggtgcggc tgatgcgcac cgaccggctc agcgacgagc acaagcgaca caactttctc      900

ggggcgccct tctgggtggg ccgcgggttc gggctgaacc tgtcggtggt gaccgacccg      960

gctcagtcca ctccactgtt cggcccgggc gggcttggca ccttcagctg gcccggtgcc     1020

tacgggacct ggtggcaggc cgatcctggc gccgacctga tcctgctgta tctgattcag     1080

cattgtcccg acttgtccgt gaacgcggcg gctgcggtcg cggggcaacc cggggctggc     1140

caagctgcgc acggcacaac cccggttcgt ccggcgcacc taccgcgcgc tcggactgta     1200

g                                                                     1201


<210>  33
<211>  311
<212>  PRT
<213>  Mycobacterium marinum

<400>  33

Met Arg Pro Ser Asn Pro Arg Ser Ala Val Asn Arg Arg Gln Leu Leu 
1               5                   10                  15      


Ala Ala Met Ala Ala Leu Leu Pro Leu Ser Ala Cys Ala Lys Ala Ala 
            20                  25                  30          


Ser Asp Gln His Met Ala Ser Thr Met Ala Val Pro Ser Pro Asp Leu 
        35                  40                  45              


Glu Ser Arg Phe Ala Glu Leu Glu Gln Lys Tyr Glu Ala Arg Leu Gly 
    50                  55                  60                  


Val Tyr Val Pro Gly Thr Asp Ala Thr Ala Ala Val Glu His Arg Gly 
65                  70                  75                  80  


Asp Glu Arg Phe Ala Phe Cys Ser Thr Phe Lys Gly Leu Leu Gly Ala 
                85                  90                  95      


Ala Val Leu His Arg Tyr Pro Ile Ala His Leu Gly Thr Val Ile Thr 
            100                 105                 110         


Tyr Asn Ser Ala Asp Ile Arg Ser Thr Ser Pro Ile Thr Glu Gln His 
        115                 120                 125             


Leu Ala Thr Gly Met Ser Ile Gly Gly Leu Cys Asp Ala Thr Ile Arg 
    130                 135                 140                 


Tyr Ser Asp Gly Thr Ala Ala Asn Leu Leu Leu Gln Asp Ile Gly Gly 
145                 150                 155                 160 


Ile Ala Ala Phe Asn Glu Tyr Leu Arg Ser Leu Gly Asp Ser Val Ser 
                165                 170                 175     


Arg Leu Asp Gln Met Glu Pro Glu Leu Asn Arg Asn Pro Pro Gly Asp 
            180                 185                 190         


Val Arg Asp Thr Thr Thr Pro His Ala Ile Ala Met Asp Tyr Gln Gln 
        195                 200                 205             


Val Val Leu Gly Asp Ala Leu Leu Pro Glu Lys Arg Asp Lys Leu Ile 
    210                 215                 220                 


Asp Trp Leu Gly Arg Ser Thr Thr Gly Ala Lys Arg Ile Arg Ala Gly 
225                 230                 235                 240 


Phe Pro Ala Asp Trp Arg Val Ile Asp Lys Thr Gly Ser Gly Glu Tyr 
                245                 250                 255     


Gly Arg Ala Asn Asp Val Ala Val Val Trp Ser Pro Gly Gly Thr Pro 
            260                 265                 270         


Tyr Val Val Ala Ile Met Thr Asp Arg Val Gly Gly Gly Pro Glu Ala 
        275                 280                 285             


Pro Trp Cys Asp Pro Leu Val Ala Asp Ala Ala Lys Cys Val Ala Asp 
    290                 295                 300                 


Val Leu Ala Gln Trp Ser Ala 
305                 310     


<210>  34
<211>  861
<212>  DNA
<213>  Escherichia coli

<400>  34
atgagtattc aacattttcg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggtgc ggtattatcc      240

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgctgcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattggta a                                                861


<210>  35
<211>  286
<212>  PRT
<213>  Escherichia coli

<400>  35

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Val Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Ala Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


<210>  36
<211>  789
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  36
atgcgccctc tcctcttcag tgcccttctc ctgctttccg ggcataccca ggccagcgaa       60

tggaacgaca gccaggccgt ggacaagcta ttcggcgcgg ccggggtgaa aggcaccttc      120

gtcctctacg atgtgcagcg gcagcgctat gtcggccatg accgggagcg cgcggaaacc      180

cgcttcgttc ccgcttccac ctacaaggtg gcgaacagcc tgatcggctt atccacaggg      240

gcggttagat ccgccgacga ggttcttccc tatggcggca agccccagcg cttcaaggcc      300

tgggagcacg acatgagcct gcgcgacgcg atcaaggcat cgaacgtacc ggtctaccag      360

gaactggcgc ggcgcatcgg cctggagcgg atgcgcgcca atgtctcgcg cctgggttac      420

ggcaacgcgg aaatcggcca ggttgtggat aacttctggt tggtgggacc gctgaagatc      480

agcgcgatgg aacagacccg ctttctgctc cgactggcgc agggagaatt gccattcccc      540

gccccggtgc agtccaccgt gcgcgccatg accctgctgg aaagcggccc gggctgggag      600

ctgcacggca agaccggctg gtgcttcgac tgcacgccgg aactcggctg gtgggtgggc      660

tgggtgaagc gcaacgagcg gctctacggc ttcgccctga acatcgacat gcccggcggc      720

gaggccgaca tcggcaagcg cgtcgaactg ggcaaggcca gtctcaaggc tctcgggata      780

ctgccctga                                                              789


<210>  37
<211>  262
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  37

Met Arg Pro Leu Leu Phe Ser Ala Leu Leu Leu Leu Ser Gly His Thr 
1               5                   10                  15      


Gln Ala Ser Glu Trp Asn Asp Ser Gln Ala Val Asp Lys Leu Phe Gly 
            20                  25                  30          


Ala Ala Gly Val Lys Gly Thr Phe Val Leu Tyr Asp Val Gln Arg Gln 
        35                  40                  45              


Arg Tyr Val Gly His Asp Arg Glu Arg Ala Glu Thr Arg Phe Val Pro 
    50                  55                  60                  


Ala Ser Thr Tyr Lys Val Ala Asn Ser Leu Ile Gly Leu Ser Thr Gly 
65                  70                  75                  80  


Ala Val Arg Ser Ala Asp Glu Val Leu Pro Tyr Gly Gly Lys Pro Gln 
                85                  90                  95      


Arg Phe Lys Ala Trp Glu His Asp Met Ser Leu Arg Asp Ala Ile Lys 
            100                 105                 110         


Ala Ser Asn Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu 
        115                 120                 125             


Glu Arg Met Arg Ala Asn Val Ser Arg Leu Gly Tyr Gly Asn Ala Glu 
    130                 135                 140                 


Ile Gly Gln Val Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile 
145                 150                 155                 160 


Ser Ala Met Glu Gln Thr Arg Phe Leu Leu Arg Leu Ala Gln Gly Glu 
                165                 170                 175     


Leu Pro Phe Pro Ala Pro Val Gln Ser Thr Val Arg Ala Met Thr Leu 
            180                 185                 190         


Leu Glu Ser Gly Pro Gly Trp Glu Leu His Gly Lys Thr Gly Trp Cys 
        195                 200                 205             


Phe Asp Cys Thr Pro Glu Leu Gly Trp Trp Val Gly Trp Val Lys Arg 
    210                 215                 220                 


Asn Glu Arg Leu Tyr Gly Phe Ala Leu Asn Ile Asp Met Pro Gly Gly 
225                 230                 235                 240 


Glu Ala Asp Ile Gly Lys Arg Val Glu Leu Gly Lys Ala Ser Leu Lys 
                245                 250                 255     


Ala Leu Gly Ile Leu Pro 
            260         


<210>  38
<211>  830
<212>  DNA
<213>  Staphylococcus aureus

<400>  38
ttgaaaaagt taatattttt aattgcaatt gctttagttt taagtgcatg taattcaaac       60

agtccacatg ccaaagagtt aatgatttag aaaaaaaata taatgctcat attggtgttt      120

atgctttaga tactaaaagt ggtaaggaag taaaatttaa ttcagataag agatttgcct      180

atgcttcgac ttcaaaagcg ataaatagtg ctattttgtt agaacaagta ccttataata      240

agttaaataa aaaaatacat attaacaaag atgatatagt tgcttattct cctattttag      300

aaaaatatgt aggaaaagat atcactttaa aagaacttat tgaggcttca atgacatata      360

gtgataatac agcaaacaat aaaattataa aagaaatcgg tggaatcaaa aaagttaaac      420

aacgtctaaa agaactagga gataaagtaa caaatccagt tagatatgag atagaattaa      480

attactattc accaaagagc aaaaaagata cttcaacacc tgctgctttc ggtaagactt      540

taaataaact tatcgcaaat ggaaaattag aaaacaaaaa attcttactt gatttaatgt      600

taaataataa aagcggagat actttaatta aagacggtgt tccaaaagac tataaggttg      660

ctgataaaag tggtcaagca ataacatatg cttctagaaa tgatgttgct tttgtttatc      720

ctaagggcca atctgtttta gtcattttta cgaataaaga caataaaagt gataagccaa      780

atgataagtt gataagtgaa accgccaaga gtgtaatgaa ggaattttaa                 830


<210>  39
<211>  303
<212>  PRT
<213>  Staphylococcus aureus

<400>  39

Met Gln Lys Phe Asp Thr Arg Thr Phe Gln Gly Leu Ile Leu Thr Leu 
1               5                   10                  15      


Gln Asp Tyr Trp Ala Arg Gln Gly Cys Thr Ile Val Gln Pro Leu Asp 
            20                  25                  30          


Met Glu Val Gly Ala Gly Thr Ser His Pro Met Thr Cys Leu Arg Ala 
        35                  40                  45              


Leu Gly Pro Glu Pro Met Ala Ala Ala Tyr Val Gln Pro Ser Arg Arg 
    50                  55                  60                  


Pro Thr Asp Gly Arg Tyr Gly Glu Asn Pro Asn Arg Leu Gln His Tyr 
65                  70                  75                  80  


Tyr Gln Phe Gln Val Val Ile Lys Pro Ser Pro Asp Asn Ile Gln Glu 
                85                  90                  95      


Leu Tyr Leu Gly Ser Leu Lys Glu Leu Gly Met Asp Pro Thr Ile His 
            100                 105                 110         


Asp Ile Arg Phe Val Glu Asp Asn Trp Glu Asn Pro Thr Leu Gly Ala 
        115                 120                 125             


Trp Gly Leu Gly Trp Glu Val Trp Leu Asn Gly Met Glu Val Thr Gln 
    130                 135                 140                 


Phe Thr Tyr Phe Gln Gln Val Gly Gly Leu Glu Cys Lys Pro Val Thr 
145                 150                 155                 160 


Gly Glu Ile Thr Tyr Gly Leu Glu Arg Leu Ala Met Tyr Ile Gln Gly 
                165                 170                 175     


Val Asp Ser Val Tyr Asp Leu Val Trp Ser Asp Gly Pro Leu Gly Lys 
            180                 185                 190         


Thr Thr Tyr Gly Asp Val Phe His Gln Asn Glu Val Glu Gln Ser Thr 
        195                 200                 205             


Tyr Asn Phe Glu Tyr Ala Asp Val Asp Phe Leu Phe Thr Cys Phe Glu 
    210                 215                 220                 


Gln Tyr Glu Lys Glu Ala Gln Gln Leu Leu Ala Leu Glu Asn Pro Leu 
225                 230                 235                 240 


Pro Leu Pro Ala Tyr Glu Arg Ile Leu Lys Ala Ala His Ser Phe Asn 
                245                 250                 255     


Leu Leu Asp Ala Arg Lys Ala Ile Ser Val Thr Glu Arg Gln Arg Tyr 
            260                 265                 270         


Ile Leu Arg Ile Arg Thr Leu Thr Lys Ala Val Ala Glu Ala Tyr Tyr 
        275                 280                 285             


Ala Ser Arg Glu Ala Leu Gly Phe Pro Met Cys Asn Lys Asp Lys 
    290                 295                 300             


<210>  40
<211>  421
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  40

Met Arg Lys Phe Leu Ile Ile Leu Leu Leu Pro Ser Phe Leu Thr Ile 
1               5                   10                  15      


Ser Lys Val Val Ser Thr Glu Lys Glu Val Val Tyr Thr Ser Lys Glu 
            20                  25                  30          


Ile Tyr Tyr Leu Ser Gln Ser Asp Phe Gly Ile Tyr Phe Arg Glu Lys 
        35                  40                  45              


Leu Ser Ser Pro Met Ala Tyr Gly Glu Val Pro Val Tyr Ala Asn Glu 
    50                  55                  60                  


Asp Leu Val Val Glu Ser Gly Lys Leu Thr Pro Lys Thr Ser Phe Gln 
65                  70                  75                  80  


Ile Thr Glu Trp Arg Leu Asn Lys Gln Gly Ile Pro Val Phe Lys Leu 
                85                  90                  95      


Ser Asn His Gln Phe Ile Ala Ala Asp Lys Arg Phe Leu Tyr Asp Gln 
            100                 105                 110         


Ser Glu Val Thr Pro Thr Ile Lys Lys Val Trp Leu Glu Ser Asp Phe 
        115                 120                 125             


Lys Leu Tyr Asn Ser Pro Tyr Asp Leu Lys Glu Val Lys Ser Ser Leu 
    130                 135                 140                 


Ser Ala Tyr Ser Gln Val Ser Ile Asp Lys Thr Met Phe Val Glu Gly 
145                 150                 155                 160 


Arg Glu Phe Leu His Ile Asp Gln Ala Gly Trp Val Ala Lys Glu Ser 
                165                 170                 175     


Thr Ser Glu Glu Asp Asn Arg Met Ser Lys Val Gln Glu Met Leu Ser 
            180                 185                 190         


Glu Lys Tyr Gln Lys Asp Ser Phe Ser Ile Tyr Val Lys Gln Leu Thr 
        195                 200                 205             


Thr Gly Lys Glu Ala Gly Ile Asn Gln Asp Glu Lys Met Tyr Ala Ala 
    210                 215                 220                 


Ser Val Leu Lys Leu Ser Tyr Leu Tyr Tyr Thr Gln Glu Lys Ile Asn 
225                 230                 235                 240 


Glu Gly Leu Tyr Gln Leu Asp Thr Thr Val Lys Tyr Val Ser Ala Val 
                245                 250                 255     


Asn Asp Phe Pro Gly Ser Tyr Lys Pro Glu Gly Ser Gly Ser Leu Pro 
            260                 265                 270         


Lys Lys Glu Asp Asn Lys Glu Tyr Ser Leu Lys Asp Leu Ile Thr Lys 
        275                 280                 285             


Val Ser Lys Glu Ser Asp Asn Val Ala His Asn Leu Leu Gly Tyr Tyr 
    290                 295                 300                 


Ile Ser Asn Gln Ser Asp Ala Thr Phe Lys Ser Lys Met Ser Ala Ile 
305                 310                 315                 320 


Met Gly Asp Asp Trp Asp Pro Lys Glu Lys Leu Ile Ser Ser Lys Met 
                325                 330                 335     


Ala Gly Lys Phe Met Glu Ala Ile Tyr Asn Gln Asn Gly Phe Val Leu 
            340                 345                 350         


Glu Ser Leu Thr Lys Thr Asp Phe Asp Ser Gln Arg Ile Ala Lys Gly 
        355                 360                 365             


Val Ser Val Lys Val Ala His Lys Ile Gly Asp Ala Asp Glu Phe Lys 
    370                 375                 380                 


His Asp Thr Gly Val Val Tyr Ala Asp Ser Pro Phe Ile Leu Ser Ile 
385                 390                 395                 400 


Phe Thr Lys Asn Ser Asp Tyr Asp Thr Ile Ser Lys Ile Ala Lys Asp 
                405                 410                 415     


Val Tyr Glu Val Leu 
            420     


