                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Aptamers

<130>  RIC/FP7134729

<150>  SG 10201405140Y
<151>  2014-08-22

<160>  87    

<170>  PatentIn version 3.3

<210>  1
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  1
agagtagtca gggatcagtg cggttcgtga tgg                                  33


<210>  2
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  2
cgagtagtca gggatcagtg cggttcgtga tgg                                  33


<210>  3
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  3
gagtagtcag ggatcagtgc ggttcgtgat gg                                   32


<210>  4
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  4
taagtagtca gggatcagtg cggttcgtga tgg                                  33


<210>  5
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  5
tgagtagtca gggatcagcg cggttcgtga tgg                                  33


<210>  6
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  6
tgagtagtca gggatcagtg cagttcgtga tgg                                  33


<210>  7
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  7
tgagtagtca gggatcagtg cggtccgtga tgg                                  33


<210>  8
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  8
tgagtagtca gggatcagtg cggttcatga tgg                                  33


<210>  9
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  9
tgagtagtca gggatcagtg cggttcgtga ggc                                  33


<210>  10
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  10
tgagtagtca gggatcagtg cggttcgtga tga                                  33


<210>  11
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  11
tgagtagtca gggatcagtg cggttcgtga tgc                                  33


<210>  12
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  12
tgagtagtca gggatcagtg cggttcgtga tgg                                  33


<210>  13
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  13
tgagtagtca gggatcagtg cggttcgtgg tgg                                  33


<210>  14
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  14
tgagtagtca gggatcagtg tggttcgtga tgg                                  33


<210>  15
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  15
tgagtagtca gggatcggtg cggttcgtga tgg                                  33


<210>  16
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  16
tgagtagtca gggattagtg cggttcgtga tgg                                  33


<210>  17
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  17
tgagtagtcg gggatcagtg cggttcgtga tgg                                  33


<210>  18
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  18
tgagtagtta gggatcagtg cggttcgtga tgg                                  33


<210>  19
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  19
tgggtagtca gggatcagtg cggttcgtga tgg                                  33


<210>  20
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n may be present or absent. If present, n = h

<400>  20
nrrgtagtyr gggatyrgtg yrgtycrtgr kgv                                  33


<210>  21
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  21
tgagtagtca gggatcagtg cggttcgtga tgg                                  33


<210>  22
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  22
gagtagtcag ggatcagtgc ggttcgtgat gg                                   32


<210>  23
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  23
aatgagattc ggcaagaccc gtcttattac aac                                  33


<210>  24
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  24
aatgagattc ggcaagaccc gtcttattac aat                                  33


<210>  25
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  25
aatgagattc ggcaagaccc gtcttattgc aac                                  33


<210>  26
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  26
aatgagattc ggcaagatcc gtcttattac aac                                  33


<210>  27
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  27
aatgagattc ggcaggaccc gtcttattac aac                                  33


<210>  28
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  28
aatgagattc ggcargaycc gtcttattrc aay                                  33


<210>  29
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  29
aatgagattc ggcaagaccc gtcttattac aac                                  33


<210>  30
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  30
atgcgtttga agttgccccg gaagtaggtt ttg                                  33


<210>  31
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  31
ttgcgtttga agttgccccg gaagtaggtt ttg                                  33


<210>  32
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  32
wtgcgtttga agttgccccg gaagtaggtt ttg                                  33


<210>  33
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  33
atgcgtttga agttgccccg gaagtaggtt ttg                                  33


<210>  34
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  34
aatgggatgg aattattgtg tattgatgac gat                                  33


<210>  35
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  35
cgtggaggtg gttgggggtt cggtgggggg ggg                                  33


<210>  36
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  36
tgtggaggtg gttgggggtt cggtgggggg gg                                   32


<210>  37
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  37
tgtggaggtg gttgggggtt cggtgggggg ggc                                  33


<210>  38
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  38
tgtggaggtg gttgggggtt cggtgggggg ggg                                  33


<210>  39
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  39
tgtggaggtg gttgggggtt cggtgggggg gggg                                 34


<210>  40
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  40
tgtggaggtg gttgggggtt cggtgggggg ggggg                                35


<210>  41
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n may be present or absent. If present, n = s

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is absent if n33 is absent. If present, n = g

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  n is absent if n34 is absent. If present, n = g

<400>  41
ygtggaggtg gttgggggtt cggtgggggg ggnnn                                35


<210>  42
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  42
tgtggaggtg gttgggggtt cggtgggggg ggg                                  33


<210>  43
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  43
aggtgggagg gtgggggtgg gaatgggggt tca                                  33


<210>  44
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  44
atgtgggagg gtgggggtgg gaatgggggt tca                                  33


<210>  45
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  45
gggtgggagg gtgggggtgg gaatgggggt tca                                  33


<210>  46
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  46
tggtgggagg gtgggggtgg gaatgggggt tca                                  33


<210>  47
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  47
dkgtgggagg gtgggggtgg gaatgggggt tca                                  33


<210>  48
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  48
aggtgggagg gtgggggtgg gaatgggggt tca                                  33


<210>  49
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  49
tatcgcaagg ctatggatcg caattcagtg gc                                   32


<210>  50
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  50
tatcgcaagg ctatggatcg caattcagtg gt                                   32


<210>  51
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  51
tatcgcaagg ctatggatcg caattcagtg gy                                   32


<210>  52
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  52
ttggttggag gtggtggggg gggggggggg gaa                                  33


<210>  53
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  53
ttggttggag gtggtggggg gggggggggg ga                                   32


<210>  54
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  54
ttggttggag gtggtggggg gggggggggg gga                                  33


<210>  55
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  55
ttggttggag gtggtggggg gggggggggg ggaa                                 34


<210>  56
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  56
ttggttggag gtggtggggg gggggggggg gg                                   32


<210>  57
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  57
ttggttggag gtggtggggg gggggggggg ggat                                 34


<210>  58
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  58
ttggttggag gtggtggggg gggggggggg ggga                                 34


<210>  59
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  59
ttggttggag gtggtggggg gggggggggg ggg                                  33


<210>  60
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  60
ttggttggag gtggtggggg gggggggggg gggg                                 34


<210>  61
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  61
ttggttggag gtggtggggg gggggggggg gggt                                 34


<210>  62
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  62
ttggttggag gtggtggggg gggggggggg ggt                                  33


<210>  63
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  63
ttggttggag gtggtggggg gggggggggg ggtt                                 34


<210>  64
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n may be present or absent. If present, n = d

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is absent if n33 is absent. If present, n = d

<400>  64
ttggttggag gtggtggggg gggggggggg grnn                                 34


<210>  65
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  65
ttggttggag gtggtggggg gggggggggg ggat                                 34


<210>  66
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  66
gagggtggta agtgtctaaa gccagttcta gcg                                  33


<210>  67
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  67
gctagttgca gctatacaac gtaacgttat gtg                                  33


<210>  68
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  68
gttaggctgg gatgtctggg cttcgcggca gta                                  33


<210>  69
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  69
gatgtacaac cttttttacc gagaacacgg tgg                                  33


<210>  70
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  70
cttccgatct                                                            10


<210>  71
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer sequence

<400>  71
agatcggaag                                                            10


<210>  72
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  72
cttccgatct tgagtagtca gggatcagtg cggttcgtga tggagatcgg aag            53


<210>  73
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  73
cttccgatct aatgagattc ggcaagaccc gtcttattac aacagatcgg aag            53


<210>  74
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  74
cttccgatct atgcgtttga agttgccccg gaagtaggtt ttgagatcgg aag            53


<210>  75
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  75
cttccgatct aatgggatgg aattattgtg tattgatgac gatagatcgg aag            53


<210>  76
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  76
cttccgatct tgtggaggtg gttgggggtt cggtgggggg gggagatcgg aag            53


<210>  77
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  77
cttccgatct aggtgggagg gtgggggtgg gaatgggggt tcaagatcgg aag            53


<210>  78
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  78
cttccgatct tatcgcaagg ctatggatcg caattcagtg gcagatcgga ag             52


<210>  79
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  79
cttccgatct ttggttggag gtggtggggg gggggggggg ggatagatcg gaag           54


<210>  80
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  80
cttccgatct gagggtggta agtgtctaaa gccagttcta gcgagatcgg aag            53


<210>  81
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  81
cttccgatct gctagttgca gctatacaac gtaacgttat gtgagatcgg aag            53


<210>  82
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  82
cttccgatct gttaggctgg gatgtctggg cttcgcggca gtaagatcgg aag            53


<210>  83
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer consensus sequence

<400>  83
cttccgatct gatgtacaac cttttttacc gagaacacgg tggagatcgg aag            53


<210>  84
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic aptamer library

<220>
<221>  misc_feature
<222>  (34)..(67)
<223>  n is a or g or c or t

<400>  84
acactctttc cctacacgac gctcttccga tctnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnagat cggaagagct c                                               81


<210>  85
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  85
acactctttc cctacacgac gctcttccga tct                                  33


<210>  86
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  86
agacgtgtgc tcttccgatc t                                               21


<210>  87
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Leu Asp Leu Thr Ser Arg Gly Gln Val Gly Thr Ser Arg Arg Met 
1               5                   10                  15      


Ala Glu Ala Ala Cys Ser Ala His Phe Leu Glu Thr Thr Pro Thr Pro 
            20                  25                  30          


Asn Pro Pro Thr Thr Glu Glu Glu Lys Thr Glu Ser Asn Gln Glu Val 
        35                  40                  45              


Ala Asn Pro Glu His Tyr Ile Lys His Pro Leu Gln Asn Arg Trp Ala 
    50                  55                  60                  


Leu Trp Phe Phe Lys Asn Asp Lys Ser Lys Thr Trp Gln Ala Asn Leu 
65                  70                  75                  80  


Arg Leu Ile Ser Lys Phe Asp Thr Val Glu Asp Phe Trp Ala Leu Tyr 
                85                  90                  95      


Asn His Ile Gln Leu Ser Ser Asn Leu Met Pro Gly Cys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Lys Asp Gly Ile Glu Pro Met Trp Glu Asp Glu Lys Asn Lys 
        115                 120                 125             


Arg Gly Gly Arg Trp Leu Ile Thr Leu Asn Lys Gln Gln Arg Arg Ser 
    130                 135                 140                 


Asp Leu Asp Arg Phe Trp Leu Glu Thr Leu Leu Cys Leu Ile Gly Glu 
145                 150                 155                 160 


Ser Phe Asp Asp Tyr Ser Asp Asp Val Cys Gly Ala Val Val Asn Val 
                165                 170                 175     


Arg Ala Lys Gly Asp Lys Ile Ala Ile Trp Thr Thr Glu Cys Glu Asn 
            180                 185                 190         


Arg Glu Ala Val Thr His Ile Gly Arg Val Tyr Lys Glu Arg Leu Gly 
        195                 200                 205             


Leu Pro Pro Lys Ile Val Ile Gly Tyr Gln Ser His Ala Asp Thr Ala 
    210                 215                 220                 


Thr Lys Ser Gly Ser Thr Thr Lys Asn Arg Phe Val Val 
225                 230                 235         


