                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<110>  Deutsches Krebsforschungszentrum 
       Stiftung des ffentlichen Rechts

<120>  Vaccines and manufacturing methods for treatment and prevention 
       of disease

<130>  789-8 PCT

<150>  EP 141 81 688.4
<151>  2014-08-20

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  1518
<212>  DNA
<213>  Human papillomavirus type 16


<220>
<221>  HPV16 L1 wildtype gene
<222>  (1)..(1518)

<400>  1
atgtctcttt ggctgcctag tgaggccact gtctacttgc ctcctgtccc agtatctaag       60

gttgtaagca cggatgaata tgttgcacgc acaaacatat attatcatgc aggaacatcc      120

agactacttg cagttggaca tccctatttt cctattaaaa aacctaacaa taacaaaata      180

ttagttccta aagtatcagg attacaatac agggtattta gaatacattt acctgacccc      240

aataagtttg gttttcctga cacctcattt tataatccag atacacagcg gctggtttgg      300

gcctgtgtag gtgttgaggt aggtcgtggt cagccattag gtgtgggcat tagtggccat      360

cctttattaa ataaattgga tgacacagaa aatgctagtg cttatgcagc aaatgcaggt      420

gtggataata gagaatgtat atctatggat tacaaacaaa cacaattgtg tttaattggt      480

tgcaaaccac ctatagggga acactggggc aaaggatccc catgtaccaa tgttgcagta      540

aatccaggtg attgtccacc attagagtta ataaacacag ttattcagga tggtgatatg      600

gttgatactg gctttggtgc tatggacttt actacattac aggctaacaa aagtgaagtt      660

ccactggata tttgtacatc tatttgcaaa tatccagatt atattaaaat ggtgtcagaa      720

ccatatggcg acagcttatt tttttattta cgaagggaac aaatgtttgt tggacattta      780

tttaataggg ctggtgctgt tggtgaaaat gtaccagacg atttatacat taaaggctct      840

gggtctactg caaatttagc cagttcaaat tattttccta cacctagtgg ttctatggtt      900

acctctgatg cccaaatatt caataaacct tattggttac aacgagcaca gggccacaat      960

aatggcattt gttggggtaa ccaactattt gttactgttg ttgatactac acgcagtaca     1020

aatatgtcat tatgtgctgc catatctact tcagaaacta catataaaaa tactaacttt     1080

aaggagtacc tacgacatgg ggaggaatat gatttacagt ttatttttca actgtgcaaa     1140

ataaccttaa ctgcagacgt tatgacatac atacattcta tgaattctac tattttggag     1200

gactggaatt ttggtctaca acctccccca ggaggcacac tagaagatac ttataggttt     1260

gtaacatccc aggcaattgc ttgtcaaaaa catacacctc cagcacctaa agaagatccc     1320

cttaaaaaat acactttttg ggaagtaaat ttaaaggaaa agttttctgc agacctagat     1380

cagtttcctt taggacgcaa atttttacta caagcaggat tgaaggccaa accaaaattt     1440

acattaggaa aacgaaaagc tacacccacc acctcatcta cctctacaac tgctaaacgc     1500

aaaaaacgta agctgtaa                                                   1518


<210>  2
<211>  505
<212>  PRT
<213>  Human papillomavirus type 16


<220>
<221>  HPV16 L1 wildtype protein
<222>  (1)..(505)

<400>  2

Met Ser Leu Trp Leu Pro Ser Glu Ala Thr Val Tyr Leu Pro Pro Val 
1               5                   10                  15      


Pro Val Ser Lys Val Val Ser Thr Asp Glu Tyr Val Ala Arg Thr Asn 
            20                  25                  30          


Ile Tyr Tyr His Ala Gly Thr Ser Arg Leu Leu Ala Val Gly His Pro 
        35                  40                  45              


Tyr Phe Pro Ile Lys Lys Pro Asn Asn Asn Lys Ile Leu Val Pro Lys 
    50                  55                  60                  


Val Ser Gly Leu Gln Tyr Arg Val Phe Arg Ile His Leu Pro Asp Pro 
65                  70                  75                  80  


Asn Lys Phe Gly Phe Pro Asp Thr Ser Phe Tyr Asn Pro Asp Thr Gln 
                85                  90                  95      


Arg Leu Val Trp Ala Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro 
            100                 105                 110         


Leu Gly Val Gly Ile Ser Gly His Pro Leu Leu Asn Lys Leu Asp Asp 
        115                 120                 125             


Thr Glu Asn Ala Ser Ala Tyr Ala Ala Asn Ala Gly Val Asp Asn Arg 
    130                 135                 140                 


Glu Cys Ile Ser Met Asp Tyr Lys Gln Thr Gln Leu Cys Leu Ile Gly 
145                 150                 155                 160 


Cys Lys Pro Pro Ile Gly Glu His Trp Gly Lys Gly Ser Pro Cys Thr 
                165                 170                 175     


Asn Val Ala Val Asn Pro Gly Asp Cys Pro Pro Leu Glu Leu Ile Asn 
            180                 185                 190         


Thr Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
        195                 200                 205             


Asp Phe Thr Thr Leu Gln Ala Asn Lys Ser Glu Val Pro Leu Asp Ile 
    210                 215                 220                 


Cys Thr Ser Ile Cys Lys Tyr Pro Asp Tyr Ile Lys Met Val Ser Glu 
225                 230                 235                 240 


Pro Tyr Gly Asp Ser Leu Phe Phe Tyr Leu Arg Arg Glu Gln Met Phe 
                245                 250                 255     


Val Arg His Leu Phe Asn Arg Ala Gly Ala Val Gly Glu Asn Val Pro 
            260                 265                 270         


Asp Asp Leu Tyr Ile Lys Gly Ser Gly Ser Thr Ala Asn Leu Ala Ser 
        275                 280                 285             


Ser Asn Tyr Phe Pro Thr Pro Ser Gly Ser Met Val Thr Ser Asp Ala 
    290                 295                 300                 


Gln Ile Phe Asn Lys Pro Tyr Trp Leu Gln Arg Ala Gln Gly His Asn 
305                 310                 315                 320 


Asn Gly Ile Cys Trp Gly Asn Gln Leu Phe Val Thr Val Val Asp Thr 
                325                 330                 335     


Thr Arg Ser Thr Asn Met Ser Leu Cys Ala Ala Ile Ser Thr Ser Glu 
            340                 345                 350         


Thr Thr Tyr Lys Asn Thr Asn Phe Lys Glu Tyr Leu Arg His Gly Glu 
        355                 360                 365             


Glu Tyr Asp Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 


Ala Asp Val Met Thr Tyr Ile His Ser Met Asn Ser Thr Ile Leu Glu 
385                 390                 395                 400 


Asp Trp Asn Phe Gly Leu Gln Pro Pro Pro Gly Gly Thr Leu Glu Asp 
                405                 410                 415     


Thr Tyr Arg Phe Val Thr Ser Gln Ala Ile Ala Cys Gln Lys His Thr 
            420                 425                 430         


Pro Pro Ala Pro Lys Glu Asp Pro Leu Lys Lys Tyr Thr Phe Trp Glu 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Phe Ser Ala Asp Leu Asp Gln Phe Pro Leu 
    450                 455                 460                 


Gly Arg Lys Phe Leu Leu Gln Ala Gly Leu Lys Ala Lys Pro Lys Phe 
465                 470                 475                 480 


Thr Leu Gly Lys Arg Lys Ala Thr Pro Thr Thr Ser Ser Thr Ser Thr 
                485                 490                 495     


Thr Ala Lys Arg Lys Lys Arg Lys Leu 
            500                 505 


<210>  3
<211>  30
<212>  DNA
<213>  Human papillomavirus type 16


<220>
<221>  Delta N10 nucleic acid
<222>  (1)..(30)
<223>  deletion of 10 aas at the N-terminus

<400>  3
atgtctcttt ggctgcctag tgaggccact                                        30


<210>  4
<211>  10
<212>  PRT
<213>  Human papillomavirus type 16


<220>
<221>  Delta N10 protein
<222>  (1)..(10)
<223>  deletion of 10 aas at the N-terminus

<400>  4

Met Ser Leu Trp Leu Pro Ser Glu Ala Thr 
1               5                   10  


<210>  5
<211>  87
<212>  DNA
<213>  Human papillomavirus type 16


<220>
<221>  deltaC29 nucleic acid
<222>  (1)..(29)
<223>  deletion of 29 aas at the terminus protein sequence

<400>  5
aaaccaaaat ttacattagg aaaacgaaaa gctacaccca ccacctcatc tacctctaca       60

actgctaaac gcaaaaaacg taagctg                                           87


<210>  6
<211>  29
<212>  PRT
<213>  Human papillomavirus type 16


<220>
<221>  deltaC29 protein
<222>  (1)..(29)
<223>  deletion of 29 aas at the C-terminus of the protein sequence

<400>  6

Lys Pro Lys Phe Thr Leu Gly Lys Arg Lys Ala Thr Pro Thr Thr Ser 
1               5                   10                  15      


Ser Thr Ser Thr Thr Ala Lys Arg Lys Lys Arg Lys Leu 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Human papillomavirus type 16


<220>
<221>  deltahelix4 protein
<222>  (1)..(29)
<223>  deletion of aas 408 - 431 that comprises the helix 4 region of 
       HPV16L1

<400>  7

Lys Pro Lys Phe Thr Leu Gly Lys Arg Lys Ala Thr Pro Thr Thr Ser 
1               5                   10                  15      


Ser Thr Ser Thr Thr Ala Lys Arg Lys Lys Arg Lys Leu 
            20                  25                  


<210>  8
<211>  33
<212>  PRT
<213>  Human papillomavirus type 16


<220>
<221>  delta helix4 protein in construct 3
<222>  (1)..(33)
<223>  delta h4 in L1delta N10 delta h4-p16INK4a-L1delta C29

<400>  8

Phe Gly Leu Gln Pro Pro Pro Gly Gly Thr Leu Glu Asp Thr Tyr Arg 
1               5                   10                  15      


Phe Val Thr Ser Gln Ala Ile Ala Cys Gln Lys His Thr Pro Pro Ala 
            20                  25                  30          


Pro 
    


<210>  9
<211>  471
<212>  DNA
<213>  Homo sapiens


<220>
<221>  p16INK4a DNA sequence
<222>  (1)..(471)
<223>  full length cyclin-dependent kinase inhibitor 2A protein (CDKN2A,
       p16INK4a), human

<400>  9
atggagccgg cggcggggag cagcatggag ccttcggctg actggctggc cacggccgcg       60

gcccggggtc gggtagagga ggtgcgggcg ctgctggagg cgggggcgct gcccaacgca      120

ccgaatagtt acggtcggag gccgatccag gtcatgatga tgggcagcgc ccgagtggcg      180

gagctgctgc tgctccacgg cgcggagccc aactgcgccg accccgccac tctcacccga      240

cccgtgcacg acgctgcccg ggagggcttc ctggacacgc tggtggtgct gcaccgggcc      300

ggggcgcggc tggacgtgcg cgatgcctgg ggccgtctgc ccgtggacct ggctgaggag      360

ctgggccatc gcgatgtcgc acggtacctg cgcgcggctg cggggggcac cagaggcagt      420

aaccatgccc gcatagatgc cgcggaaggt ccctcagaca tccccgattg a               471


<210>  10
<211>  156
<212>  PRT
<213>  Homo sapiens


<220>
<221>  p16INK4a protein sequence
<222>  (1)..(156)
<223>  p16INK4a protein sequence

<400>  10

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  11
<211>  6338
<212>  DNA
<213>  artificial sequence (bacterial expression vector)

<220>
<223>  pGEX expression vector with insert


<220>
<221>  pGEX-L1-delta N10-delta-h4-deltaC29
<222>  (1)..(6338)
<223>  modified HPV 16 L1, forms capsomeres

<400>  11
acgttatcga ctgcacggtg caccaatgct tctggcgtca ggcagccatc ggaagctgtg       60

gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc gcactcccgt      120

tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc tgaaatgagc      180

tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat aacaatttca      240

cacaggaaac agtattcatg tcccctatac taggttattg gaaaattaag ggccttgtgc      300

aacccactcg acttcttttg gaatatcttg aagaaaaata tgaagagcat ttgtatgagc      360

gcgatgaagg tgataaatgg cgaaacaaaa agtttgaatt gggtttggag tttcccaatc      420

ttccttatta tattgatggt gatgttaaat taacacagtc tatggccatc atacgttata      480

tagctgacaa gcacaacatg ttgggtggtt gtccaaaaga gcgtgcagag atttcaatgc      540

ttgaaggagc ggttttggat attagatacg gtgtttcgag aattgcatat agtaaagact      600

ttgaaactct caaagttgat tttcttagca agctacctga aatgctgaaa atgttcgaag      660

atcgtttatg tcataaaaca tatttaaatg gtgatcatgt aacccatcct gacttcatgt      720

tgtatgacgc tcttgatgtt gttttataca tggacccaat gtgcctggat gcgttcccaa      780

aattagtttg ttttaaaaaa cgtattgaag ctatcccaca aattgataag tacttgaaat      840

ccagcaagta tatagcatgg cctttgcagg gctggcaagc cacgtttggt ggtggcgacc      900

atcctccaaa atcggatctg gttccgcgtg gatccgtcta cttgcctcct gtcccagtat      960

ctaaggttgt aagcacggat gaatatgttg cacgcacaaa catatattat catgcaggaa     1020

catccagact acttgcagtt ggacatccct attttcctat taaaaaacct aacaataaca     1080

aaatattagt tcctaaagta tcaggattac aatacagggt atttagaata catttacctg     1140

accccaataa gtttggtttt cctgacacct cattttataa tccagataca cagcggctgg     1200

tttgggcctg tgtaggtgtt gaggtaggtc gtggtcagcc attaggtgtg ggcattagtg     1260

gccatccttt attaaataaa ttggatgaca cagaaaatgc tagtgcttat gcagcaaatg     1320

caggtgtgga taatagagaa tgtatatcta tggattacaa acaaacacaa ttgtgtttaa     1380

ttggttgcaa accacctata ggggaacact ggggcaaagg ctccccatgt accaatgttg     1440

cagtaaatcc aggtgattgt ccaccattag agttaataaa cacagttatt caggatggtg     1500

atatggttga tactggcttt ggtgctatgg actttactac attacaggct aacaaaagtg     1560

aagttccact ggatatttgt acatctattt gcaaatatcc agattatatt aaaatggtgt     1620

cagaaccata tggcgacagc ttattttttt atttacgaag ggaacaaatg tttgttagac     1680

atttatttaa tagggctggt gctgttggtg aaaatgtacc agacgattta tacattaaag     1740

gctctgggtc tactgcaaat ttagccagtt caaattattt tcctacacct agtggttcta     1800

tggttacctc tgatgcccaa atattcaata aaccttattg gttacaacga gcacagggcc     1860

acaataatgg catttgttgg ggtaaccaac tatttgttac tgttgttgat actacacgca     1920

gtacaaatat gtcattatgt gctgccatat ctacttcaga aactacatat aaaaatacta     1980

actttaagga gtacctacga catggggagg aatatgattt acagtttatt tttcaactgt     2040

gcaaaataac cttaactgca gacgttatga catacataca ttctatgaat tccactattt     2100

tggaggactg gaattttggt ctacaaacac ctccagcacc taaagaagat ccccttaaaa     2160

aatacacttt ttgggaagta aatttaaagg aaaagttttc tgcagaccta gatcagtttc     2220

ctttaggacg caaattttta ctacaagcag gattgaaggc gatgcattga aagcttatcg     2280

ataccgtcga caaacctccc acacctcccc ctgaacctga aacataagcg gccgcatcgt     2340

gactgactga cgatctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg     2400

cagctcccgg agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt     2460

cagggcgcgt cagcgggtgt tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc     2520

gatagcggag tgtataattc ttgaagacga aagggcctcg tgatacgcct atttttatag     2580

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     2640

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     2700

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     2760

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     2820

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     2880

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     2940

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtgt tgacgccggg     3000

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     3060

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     3120

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     3180

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     3240

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgc agcaatggca     3300

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     3360

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     3420

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     3480

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     3540

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     3600

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     3660

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     3720

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     3780

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     3840

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     3900

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     3960

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     4020

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     4080

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     4140

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     4200

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     4260

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     4320

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     4380

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     4440

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     4500

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     4560

tattttctcc ttacgcatct gtgcggtatt tcacaccgca taaattccga caccatcgaa     4620

tggtgcaaaa cctttcgcgg tatggcatga tagcgcccgg aagagagtca attcagggtg     4680

gtgaatgtga aaccagtaac gttatacgat gtcgcagagt atgccggtgt ctcttatcag     4740

accgtttccc gcgtggtgaa ccaggccagc cacgtttctg cgaaaacgcg ggaaaaagtg     4800

gaagcggcga tggcggagct gaattacatt cccaaccgcg tggcacaaca actggcgggc     4860

aaacagtcgt tgctgattgg cgttgccacc tccagtctgg ccctgcacgc gccgtcgcaa     4920

attgtcgcgg cgattaaatc tcgcgccgat caactgggtg ccagcgtggt ggtgtcgatg     4980

gtagaacgaa gcggcgtcga agcctgtaaa gcggcggtgc acaatcttct cgcgcaacgc     5040

gtcagtgggc tgatcattaa ctatccgctg gatgaccagg atgccattgc tgtggaagct     5100

gcctgcacta atgttccggc gttatttctt gatgtctctg accagacacc catcaacagt     5160

attattttct cccatgaaga cggtacgcga ctgggcgtgg agcatctggt cgcattgggt     5220

caccagcaaa tcgcgctgtt agcgggccca ttaagttctg tctcggcgcg tctgcgtctg     5280

gctggctggc ataaatatct cactcgcaat caaattcagc cgatagcgga acgggaaggc     5340

gactggagtg ccatgtccgg ttttcaacaa accatgcaaa tgctgaatga gggcatcgtt     5400

cccactgcga tgctggttgc caacgatcag atggcgctgg gcgcaatgcg cgccattacc     5460

gagtccgggc tgcgcgttgg tgcggatatc tcggtagtgg gatacgacga taccgaagac     5520

agctcatgtt atatcccgcc gttaaccacc atcaaacagg attttcgcct gctggggcaa     5580

accagcgtgg accgcttgct gcaactctct cagggccagg cggtgaaggg caatcagctg     5640

ttgcccgtct cactggtgaa aagaaaaacc accctggcgc ccaatacgca aaccgcctct     5700

ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc     5760

gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt     5820

acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac     5880

aggaaacagc tatgaccatg attacggatt cactggccgt cgttttacaa cgtcgtgact     5940

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     6000

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg     6060

gcgaatggcg ctttgcctgg tttccggcac cagaagcggt gccggaaagc tggctggagt     6120

gcgatcttcc tgaggccgat actgtcgtcg tcccctcaaa ctggcagatg cacggttacg     6180

atgcgcccat ctacaccaac gtaacctatc ccattacggt caatccgccg tttgttccca     6240

cggagaatcc gacgggttgt tactcgctca catttaatgt tgatgaaagc tggctacagg     6300

aaggccagac gcgaattatt tttgatggcg ttggaatt                             6338


<210>  12
<211>  5474
<212>  PRT
<213>  artificial sequence

<220>
<223>  pGex with full length human p16INK4a gene


<220>
<221>  pGex-p16INK4a
<222>  (1)..(5474)
<223>  full-length human p16INK4a gene

<400>  12

Ala Cys Gly Thr Thr Ala Thr Cys Gly Ala Cys Thr Gly Cys Ala Cys 
1               5                   10                  15      


Gly Gly Thr Gly Cys Ala Cys Cys Ala Ala Thr Gly Cys Thr Thr Cys 
            20                  25                  30          


Thr Gly Gly Cys Gly Thr Cys Ala Gly Gly Cys Ala Gly Cys Cys Ala 
        35                  40                  45              


Thr Cys Gly Gly Ala Ala Gly Cys Thr Gly Thr Gly Gly Thr Ala Thr 
    50                  55                  60                  


Gly Gly Cys Thr Gly Thr Gly Cys Ala Gly Gly Thr Cys Gly Thr Ala 
65                  70                  75                  80  


Ala Ala Thr Cys Ala Cys Thr Gly Cys Ala Thr Ala Ala Thr Thr Cys 
                85                  90                  95      


Gly Thr Gly Thr Cys Gly Cys Thr Cys Ala Ala Gly Gly Cys Gly Cys 
            100                 105                 110         


Ala Cys Thr Cys Cys Cys Gly Thr Thr Cys Thr Gly Gly Ala Thr Ala 
        115                 120                 125             


Ala Thr Gly Thr Thr Thr Thr Thr Thr Gly Cys Gly Cys Cys Gly Ala 
    130                 135                 140                 


Cys Ala Thr Cys Ala Thr Ala Ala Cys Gly Gly Thr Thr Cys Thr Gly 
145                 150                 155                 160 


Gly Cys Ala Ala Ala Thr Ala Thr Thr Cys Thr Gly Ala Ala Ala Thr 
                165                 170                 175     


Gly Ala Gly Cys Thr Gly Thr Thr Gly Ala Cys Ala Ala Thr Thr Ala 
            180                 185                 190         


Ala Thr Cys Ala Thr Cys Gly Gly Cys Thr Cys Gly Thr Ala Thr Ala 
        195                 200                 205             


Ala Thr Gly Thr Gly Thr Gly Gly Ala Ala Thr Thr Gly Thr Gly Ala 
    210                 215                 220                 


Gly Cys Gly Gly Ala Thr Ala Ala Cys Ala Ala Thr Thr Thr Cys Ala 
225                 230                 235                 240 


Cys Ala Cys Ala Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Thr Thr 
                245                 250                 255     


Cys Ala Thr Gly Thr Cys Cys Cys Cys Thr Ala Thr Ala Cys Thr Ala 
            260                 265                 270         


Gly Gly Thr Thr Ala Thr Thr Gly Gly Ala Ala Ala Ala Thr Thr Ala 
        275                 280                 285             


Ala Gly Gly Gly Cys Cys Thr Thr Gly Thr Gly Cys Ala Ala Cys Cys 
    290                 295                 300                 


Cys Ala Cys Thr Cys Gly Ala Cys Thr Thr Cys Thr Thr Thr Thr Gly 
305                 310                 315                 320 


Gly Ala Ala Thr Ala Thr Cys Thr Thr Gly Ala Ala Gly Ala Ala Ala 
                325                 330                 335     


Ala Ala Thr Ala Thr Gly Ala Ala Gly Ala Gly Cys Ala Thr Thr Thr 
            340                 345                 350         


Gly Thr Ala Thr Gly Ala Gly Cys Gly Cys Gly Ala Thr Gly Ala Ala 
        355                 360                 365             


Gly Gly Thr Gly Ala Thr Ala Ala Ala Thr Gly Gly Cys Gly Ala Ala 
    370                 375                 380                 


Ala Cys Ala Ala Ala Ala Ala Gly Thr Thr Thr Gly Ala Ala Thr Thr 
385                 390                 395                 400 


Gly Gly Gly Thr Thr Thr Gly Gly Ala Gly Thr Thr Thr Cys Cys Cys 
                405                 410                 415     


Ala Ala Thr Cys Thr Thr Cys Cys Thr Thr Ala Thr Thr Ala Thr Ala 
            420                 425                 430         


Thr Thr Gly Ala Thr Gly Gly Thr Gly Ala Thr Gly Thr Thr Ala Ala 
        435                 440                 445             


Ala Thr Thr Ala Ala Cys Ala Cys Ala Gly Thr Cys Thr Ala Thr Gly 
    450                 455                 460                 


Gly Cys Cys Ala Thr Cys Ala Thr Ala Cys Gly Thr Thr Ala Thr Ala 
465                 470                 475                 480 


Thr Ala Gly Cys Thr Gly Ala Cys Ala Ala Gly Cys Ala Cys Ala Ala 
                485                 490                 495     


Cys Ala Thr Gly Thr Thr Gly Gly Gly Thr Gly Gly Thr Thr Gly Thr 
            500                 505                 510         


Cys Cys Ala Ala Ala Ala Gly Ala Gly Cys Gly Thr Gly Cys Ala Gly 
        515                 520                 525             


Ala Gly Ala Thr Thr Thr Cys Ala Ala Thr Gly Cys Thr Thr Gly Ala 
    530                 535                 540                 


Ala Gly Gly Ala Gly Cys Gly Gly Thr Thr Thr Thr Gly Gly Ala Thr 
545                 550                 555                 560 


Ala Thr Thr Ala Gly Ala Thr Ala Cys Gly Gly Thr Gly Thr Thr Thr 
                565                 570                 575     


Cys Gly Ala Gly Ala Ala Thr Thr Gly Cys Ala Thr Ala Thr Ala Gly 
            580                 585                 590         


Thr Ala Ala Ala Gly Ala Cys Thr Thr Thr Gly Ala Ala Ala Cys Thr 
        595                 600                 605             


Cys Thr Cys Ala Ala Ala Gly Thr Thr Gly Ala Thr Thr Thr Thr Cys 
    610                 615                 620                 


Thr Thr Ala Gly Cys Ala Ala Gly Cys Thr Ala Cys Cys Thr Gly Ala 
625                 630                 635                 640 


Ala Ala Thr Gly Cys Thr Gly Ala Ala Ala Ala Thr Gly Thr Thr Cys 
                645                 650                 655     


Gly Ala Ala Gly Ala Thr Cys Gly Thr Thr Thr Ala Thr Gly Thr Cys 
            660                 665                 670         


Ala Thr Ala Ala Ala Ala Cys Ala Thr Ala Thr Thr Thr Ala Ala Ala 
        675                 680                 685             


Thr Gly Gly Thr Gly Ala Thr Cys Ala Thr Gly Thr Ala Ala Cys Cys 
    690                 695                 700                 


Cys Ala Thr Cys Cys Thr Gly Ala Cys Thr Thr Cys Ala Thr Gly Thr 
705                 710                 715                 720 


Thr Gly Thr Ala Thr Gly Ala Cys Gly Cys Thr Cys Thr Thr Gly Ala 
                725                 730                 735     


Thr Gly Thr Thr Gly Thr Thr Thr Thr Ala Thr Ala Cys Ala Thr Gly 
            740                 745                 750         


Gly Ala Cys Cys Cys Ala Ala Thr Gly Thr Gly Cys Cys Thr Gly Gly 
        755                 760                 765             


Ala Thr Gly Cys Gly Thr Thr Cys Cys Cys Ala Ala Ala Ala Thr Thr 
    770                 775                 780                 


Ala Gly Thr Thr Thr Gly Thr Thr Thr Thr Ala Ala Ala Ala Ala Ala 
785                 790                 795                 800 


Cys Gly Thr Ala Thr Thr Gly Ala Ala Gly Cys Thr Ala Thr Cys Cys 
                805                 810                 815     


Cys Ala Cys Ala Ala Ala Thr Thr Gly Ala Thr Ala Ala Gly Thr Ala 
            820                 825                 830         


Cys Thr Thr Gly Ala Ala Ala Thr Cys Cys Ala Gly Cys Ala Ala Gly 
        835                 840                 845             


Thr Ala Thr Ala Thr Ala Gly Cys Ala Thr Gly Gly Cys Cys Thr Thr 
    850                 855                 860                 


Thr Gly Cys Ala Gly Gly Gly Cys Thr Gly Gly Cys Ala Ala Gly Cys 
865                 870                 875                 880 


Cys Ala Cys Gly Thr Thr Thr Gly Gly Thr Gly Gly Thr Gly Gly Cys 
                885                 890                 895     


Gly Ala Cys Cys Ala Thr Cys Cys Thr Cys Cys Ala Ala Ala Ala Thr 
            900                 905                 910         


Cys Gly Gly Ala Thr Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Gly 
        915                 920                 925             


Thr Gly Gly Ala Thr Cys Cys Ala Thr Gly Gly Ala Gly Cys Cys Gly 
    930                 935                 940                 


Gly Cys Gly Gly Cys Gly Gly Gly Gly Ala Gly Cys Ala Gly Cys Ala 
945                 950                 955                 960 


Thr Gly Gly Ala Gly Cys Cys Thr Thr Cys Gly Gly Cys Thr Gly Ala 
                965                 970                 975     


Cys Thr Gly Gly Cys Thr Gly Gly Cys Cys Ala Cys Gly Gly Cys Cys 
            980                 985                 990         


Gly Cys Gly Gly Cys Cys Cys Gly  Gly Gly Gly Thr Cys  Gly Gly Gly 
        995                 1000                 1005             


Thr Ala  Gly Ala Gly Gly Ala  Gly Gly Thr Gly Cys  Gly Gly Gly 
    1010                 1015                 1020             


Cys Gly  Cys Thr Gly Cys Thr  Gly Gly Ala Gly Gly  Cys Gly Gly 
    1025                 1030                 1035             


Gly Gly  Gly Cys Gly Cys Thr  Gly Cys Cys Cys Ala  Ala Cys Gly 
    1040                 1045                 1050             


Cys Ala  Cys Cys Gly Ala Ala  Thr Ala Gly Thr Thr  Ala Cys Gly 
    1055                 1060                 1065             


Gly Thr  Cys Gly Gly Ala Gly  Gly Cys Cys Gly Ala  Thr Cys Cys 
    1070                 1075                 1080             


Ala Gly  Gly Thr Cys Ala Thr  Gly Ala Thr Gly Ala  Thr Gly Gly 
    1085                 1090                 1095             


Gly Cys  Ala Gly Cys Gly Cys  Cys Cys Gly Ala Gly  Thr Gly Gly 
    1100                 1105                 1110             


Cys Gly  Gly Ala Gly Cys Thr  Gly Cys Thr Gly Cys  Thr Gly Cys 
    1115                 1120                 1125             


Thr Cys  Cys Ala Cys Gly Gly  Cys Gly Cys Gly Gly  Ala Gly Cys 
    1130                 1135                 1140             


Cys Cys  Ala Ala Cys Thr Gly  Cys Gly Cys Cys Gly  Ala Cys Cys 
    1145                 1150                 1155             


Cys Cys  Gly Cys Cys Ala Cys  Thr Cys Thr Cys Ala  Cys Cys Cys 
    1160                 1165                 1170             


Gly Ala  Cys Cys Cys Gly Thr  Gly Cys Ala Cys Gly  Ala Cys Gly 
    1175                 1180                 1185             


Cys Thr  Gly Cys Cys Cys Gly  Gly Gly Ala Gly Gly  Gly Cys Thr 
    1190                 1195                 1200             


Thr Cys  Cys Thr Gly Gly Ala  Cys Ala Cys Gly Cys  Thr Gly Gly 
    1205                 1210                 1215             


Thr Gly  Gly Thr Gly Cys Thr  Gly Cys Ala Cys Cys  Gly Gly Gly 
    1220                 1225                 1230             


Cys Cys  Gly Gly Gly Gly Cys  Gly Cys Gly Gly Cys  Thr Gly Gly 
    1235                 1240                 1245             


Ala Cys  Gly Thr Gly Cys Gly  Cys Gly Ala Thr Gly  Cys Cys Thr 
    1250                 1255                 1260             


Gly Gly  Gly Gly Cys Cys Gly  Thr Cys Thr Gly Cys  Cys Cys Gly 
    1265                 1270                 1275             


Thr Gly  Gly Ala Cys Cys Thr  Gly Gly Cys Thr Gly  Ala Gly Gly 
    1280                 1285                 1290             


Ala Gly  Cys Thr Gly Gly Gly  Cys Cys Ala Thr Cys  Gly Cys Gly 
    1295                 1300                 1305             


Ala Thr  Gly Thr Cys Gly Cys  Ala Cys Gly Gly Thr  Ala Cys Cys 
    1310                 1315                 1320             


Thr Gly  Cys Gly Cys Gly Cys  Gly Gly Cys Thr Gly  Cys Gly Gly 
    1325                 1330                 1335             


Gly Gly  Gly Gly Cys Ala Cys  Cys Ala Gly Ala Gly  Gly Cys Ala 
    1340                 1345                 1350             


Gly Thr  Ala Ala Cys Cys Ala  Thr Gly Cys Cys Cys  Gly Cys Ala 
    1355                 1360                 1365             


Thr Ala  Gly Ala Thr Gly Cys  Cys Gly Cys Gly Gly  Ala Ala Gly 
    1370                 1375                 1380             


Gly Thr  Cys Cys Cys Thr Cys  Ala Gly Ala Cys Ala  Thr Cys Cys 
    1385                 1390                 1395             


Cys Cys  Gly Ala Thr Thr Ala  Ala Ala Ala Gly Cys  Thr Thr Ala 
    1400                 1405                 1410             


Thr Cys  Gly Ala Thr Ala Cys  Cys Gly Thr Cys Gly  Ala Cys Ala 
    1415                 1420                 1425             


Ala Ala  Cys Cys Thr Cys Cys  Cys Ala Cys Ala Cys  Cys Thr Cys 
    1430                 1435                 1440             


Cys Cys  Cys Cys Thr Gly Ala  Ala Cys Cys Thr Gly  Ala Ala Ala 
    1445                 1450                 1455             


Cys Ala  Thr Ala Ala Gly Cys  Gly Gly Cys Cys Gly  Cys Ala Thr 
    1460                 1465                 1470             


Cys Gly  Thr Gly Ala Cys Thr  Gly Ala Cys Thr Gly  Ala Cys Gly 
    1475                 1480                 1485             


Ala Thr  Cys Thr Gly Cys Cys  Thr Cys Gly Cys Gly  Cys Gly Thr 
    1490                 1495                 1500             


Thr Thr  Cys Gly Gly Thr Gly  Ala Thr Gly Ala Cys  Gly Gly Thr 
    1505                 1510                 1515             


Gly Ala  Ala Ala Ala Cys Cys  Thr Cys Thr Gly Ala  Cys Ala Cys 
    1520                 1525                 1530             


Ala Thr  Gly Cys Ala Gly Cys  Thr Cys Cys Cys Gly  Gly Ala Gly 
    1535                 1540                 1545             


Ala Cys  Gly Gly Thr Cys Ala  Cys Ala Gly Cys Thr  Thr Gly Thr 
    1550                 1555                 1560             


Cys Thr  Gly Thr Ala Ala Gly  Cys Gly Gly Ala Thr  Gly Cys Cys 
    1565                 1570                 1575             


Gly Gly  Gly Ala Gly Cys Ala  Gly Ala Cys Ala Ala  Gly Cys Cys 
    1580                 1585                 1590             


Cys Gly  Thr Cys Ala Gly Gly  Gly Cys Gly Cys Gly  Thr Cys Ala 
    1595                 1600                 1605             


Gly Cys  Gly Gly Gly Thr Gly  Thr Thr Gly Gly Cys  Gly Gly Gly 
    1610                 1615                 1620             


Thr Gly  Thr Cys Gly Gly Gly  Gly Cys Gly Cys Ala  Gly Cys Cys 
    1625                 1630                 1635             


Ala Thr  Gly Ala Cys Cys Cys  Ala Gly Thr Cys Ala  Cys Gly Thr 
    1640                 1645                 1650             


Ala Gly  Cys Gly Ala Thr Ala  Gly Cys Gly Gly Ala  Gly Thr Gly 
    1655                 1660                 1665             


Thr Ala  Thr Ala Ala Thr Thr  Cys Thr Thr Gly Ala  Ala Gly Ala 
    1670                 1675                 1680             


Cys Gly  Ala Ala Ala Gly Gly  Gly Cys Cys Thr Cys  Gly Thr Gly 
    1685                 1690                 1695             


Ala Thr  Ala Cys Gly Cys Cys  Thr Ala Thr Thr Thr  Thr Thr Ala 
    1700                 1705                 1710             


Thr Ala  Gly Gly Thr Thr Ala  Ala Thr Gly Thr Cys  Ala Thr Gly 
    1715                 1720                 1725             


Ala Thr  Ala Ala Thr Ala Ala  Thr Gly Gly Thr Thr  Thr Cys Thr 
    1730                 1735                 1740             


Thr Ala  Gly Ala Cys Gly Thr  Cys Ala Gly Gly Thr  Gly Gly Cys 
    1745                 1750                 1755             


Ala Cys  Thr Thr Thr Thr Cys  Gly Gly Gly Gly Ala  Ala Ala Thr 
    1760                 1765                 1770             


Gly Thr  Gly Cys Gly Cys Gly  Gly Ala Ala Cys Cys  Cys Cys Thr 
    1775                 1780                 1785             


Ala Thr  Thr Thr Gly Thr Thr  Thr Ala Thr Thr Thr  Thr Thr Cys 
    1790                 1795                 1800             


Thr Ala  Ala Ala Thr Ala Cys  Ala Thr Thr Cys Ala  Ala Ala Thr 
    1805                 1810                 1815             


Ala Thr  Gly Thr Ala Thr Cys  Cys Gly Cys Thr Cys  Ala Thr Gly 
    1820                 1825                 1830             


Ala Gly  Ala Cys Ala Ala Thr  Ala Ala Cys Cys Cys  Thr Gly Ala 
    1835                 1840                 1845             


Thr Ala  Ala Ala Thr Gly Cys  Thr Thr Cys Ala Ala  Thr Ala Ala 
    1850                 1855                 1860             


Thr Ala  Thr Thr Gly Ala Ala  Ala Ala Ala Gly Gly  Ala Ala Gly 
    1865                 1870                 1875             


Ala Gly  Thr Ala Thr Gly Ala  Gly Thr Ala Thr Thr  Cys Ala Ala 
    1880                 1885                 1890             


Cys Ala  Thr Thr Thr Cys Cys  Gly Thr Gly Thr Cys  Gly Cys Cys 
    1895                 1900                 1905             


Cys Thr  Thr Ala Thr Thr Cys  Cys Cys Thr Thr Thr  Thr Thr Thr 
    1910                 1915                 1920             


Gly Cys  Gly Gly Cys Ala Thr  Thr Thr Thr Gly Cys  Cys Thr Thr 
    1925                 1930                 1935             


Cys Cys  Thr Gly Thr Thr Thr  Thr Thr Gly Cys Thr  Cys Ala Cys 
    1940                 1945                 1950             


Cys Cys  Ala Gly Ala Ala Ala  Cys Gly Cys Thr Gly  Gly Thr Gly 
    1955                 1960                 1965             


Ala Ala  Ala Gly Thr Ala Ala  Ala Ala Gly Ala Thr  Gly Cys Thr 
    1970                 1975                 1980             


Gly Ala  Ala Gly Ala Thr Cys  Ala Gly Thr Thr Gly  Gly Gly Thr 
    1985                 1990                 1995             


Gly Cys  Ala Cys Gly Ala Gly  Thr Gly Gly Gly Thr  Thr Ala Cys 
    2000                 2005                 2010             


Ala Thr  Cys Gly Ala Ala Cys  Thr Gly Gly Ala Thr  Cys Thr Cys 
    2015                 2020                 2025             


Ala Ala  Cys Ala Gly Cys Gly  Gly Thr Ala Ala Gly  Ala Thr Cys 
    2030                 2035                 2040             


Cys Thr  Thr Gly Ala Gly Ala  Gly Thr Thr Thr Thr  Cys Gly Cys 
    2045                 2050                 2055             


Cys Cys  Cys Gly Ala Ala Gly  Ala Ala Cys Gly Thr  Thr Thr Thr 
    2060                 2065                 2070             


Cys Cys  Ala Ala Thr Gly Ala  Thr Gly Ala Gly Cys  Ala Cys Thr 
    2075                 2080                 2085             


Thr Thr  Thr Ala Ala Ala Gly  Thr Thr Cys Thr Gly  Cys Thr Ala 
    2090                 2095                 2100             


Thr Gly  Thr Gly Gly Cys Gly  Cys Gly Gly Thr Ala  Thr Thr Ala 
    2105                 2110                 2115             


Thr Cys  Cys Cys Gly Thr Gly  Thr Thr Gly Ala Cys  Gly Cys Cys 
    2120                 2125                 2130             


Gly Gly  Gly Cys Ala Ala Gly  Ala Gly Cys Ala Ala  Cys Thr Cys 
    2135                 2140                 2145             


Gly Gly  Thr Cys Gly Cys Cys  Gly Cys Ala Thr Ala  Cys Ala Cys 
    2150                 2155                 2160             


Thr Ala  Thr Thr Cys Thr Cys  Ala Gly Ala Ala Thr  Gly Ala Cys 
    2165                 2170                 2175             


Thr Thr  Gly Gly Thr Thr Gly  Ala Gly Thr Ala Cys  Thr Cys Ala 
    2180                 2185                 2190             


Cys Cys  Ala Gly Thr Cys Ala  Cys Ala Gly Ala Ala  Ala Ala Gly 
    2195                 2200                 2205             


Cys Ala  Thr Cys Thr Thr Ala  Cys Gly Gly Ala Thr  Gly Gly Cys 
    2210                 2215                 2220             


Ala Thr  Gly Ala Cys Ala Gly  Thr Ala Ala Gly Ala  Gly Ala Ala 
    2225                 2230                 2235             


Thr Thr  Ala Thr Gly Cys Ala  Gly Thr Gly Cys Thr  Gly Cys Cys 
    2240                 2245                 2250             


Ala Thr  Ala Ala Cys Cys Ala  Thr Gly Ala Gly Thr  Gly Ala Thr 
    2255                 2260                 2265             


Ala Ala  Cys Ala Cys Thr Gly  Cys Gly Gly Cys Cys  Ala Ala Cys 
    2270                 2275                 2280             


Thr Thr  Ala Cys Thr Thr Cys  Thr Gly Ala Cys Ala  Ala Cys Gly 
    2285                 2290                 2295             


Ala Thr  Cys Gly Gly Ala Gly  Gly Ala Cys Cys Gly  Ala Ala Gly 
    2300                 2305                 2310             


Gly Ala  Gly Cys Thr Ala Ala  Cys Cys Gly Cys Thr  Thr Thr Thr 
    2315                 2320                 2325             


Thr Thr  Gly Cys Ala Cys Ala  Ala Cys Ala Thr Gly  Gly Gly Gly 
    2330                 2335                 2340             


Gly Ala  Thr Cys Ala Thr Gly  Thr Ala Ala Cys Thr  Cys Gly Cys 
    2345                 2350                 2355             


Cys Thr  Thr Gly Ala Thr Cys  Gly Thr Thr Gly Gly  Gly Ala Ala 
    2360                 2365                 2370             


Cys Cys  Gly Gly Ala Gly Cys  Thr Gly Ala Ala Thr  Gly Ala Ala 
    2375                 2380                 2385             


Gly Cys  Cys Ala Thr Ala Cys  Cys Ala Ala Ala Cys  Gly Ala Cys 
    2390                 2395                 2400             


Gly Ala  Gly Cys Gly Thr Gly  Ala Cys Ala Cys Cys  Ala Cys Gly 
    2405                 2410                 2415             


Ala Thr  Gly Cys Cys Thr Gly  Cys Ala Gly Cys Ala  Ala Thr Gly 
    2420                 2425                 2430             


Gly Cys  Ala Ala Cys Ala Ala  Cys Gly Thr Thr Gly  Cys Gly Cys 
    2435                 2440                 2445             


Ala Ala  Ala Cys Thr Ala Thr  Thr Ala Ala Cys Thr  Gly Gly Cys 
    2450                 2455                 2460             


Gly Ala  Ala Cys Thr Ala Cys  Thr Thr Ala Cys Thr  Cys Thr Ala 
    2465                 2470                 2475             


Gly Cys  Thr Thr Cys Cys Cys  Gly Gly Cys Ala Ala  Cys Ala Ala 
    2480                 2485                 2490             


Thr Thr  Ala Ala Thr Ala Gly  Ala Cys Thr Gly Gly  Ala Thr Gly 
    2495                 2500                 2505             


Gly Ala  Gly Gly Cys Gly Gly  Ala Thr Ala Ala Ala  Gly Thr Thr 
    2510                 2515                 2520             


Gly Cys  Ala Gly Gly Ala Cys  Cys Ala Cys Thr Thr  Cys Thr Gly 
    2525                 2530                 2535             


Cys Gly  Cys Thr Cys Gly Gly  Cys Cys Cys Thr Thr  Cys Cys Gly 
    2540                 2545                 2550             


Gly Cys  Thr Gly Gly Cys Thr  Gly Gly Thr Thr Thr  Ala Thr Thr 
    2555                 2560                 2565             


Gly Cys  Thr Gly Ala Thr Ala  Ala Ala Thr Cys Thr  Gly Gly Ala 
    2570                 2575                 2580             


Gly Cys  Cys Gly Gly Thr Gly  Ala Gly Cys Gly Thr  Gly Gly Gly 
    2585                 2590                 2595             


Thr Cys  Thr Cys Gly Cys Gly  Gly Thr Ala Thr Cys  Ala Thr Thr 
    2600                 2605                 2610             


Gly Cys  Ala Gly Cys Ala Cys  Thr Gly Gly Gly Gly  Cys Cys Ala 
    2615                 2620                 2625             


Gly Ala  Thr Gly Gly Thr Ala  Ala Gly Cys Cys Cys  Thr Cys Cys 
    2630                 2635                 2640             


Cys Gly  Thr Ala Thr Cys Gly  Thr Ala Gly Thr Thr  Ala Thr Cys 
    2645                 2650                 2655             


Thr Ala  Cys Ala Cys Gly Ala  Cys Gly Gly Gly Gly  Ala Gly Thr 
    2660                 2665                 2670             


Cys Ala  Gly Gly Cys Ala Ala  Cys Thr Ala Thr Gly  Gly Ala Thr 
    2675                 2680                 2685             


Gly Ala  Ala Cys Gly Ala Ala  Ala Thr Ala Gly Ala  Cys Ala Gly 
    2690                 2695                 2700             


Ala Thr  Cys Gly Cys Thr Gly  Ala Gly Ala Thr Ala  Gly Gly Thr 
    2705                 2710                 2715             


Gly Cys  Cys Thr Cys Ala Cys  Thr Gly Ala Thr Thr  Ala Ala Gly 
    2720                 2725                 2730             


Cys Ala  Thr Thr Gly Gly Thr  Ala Ala Cys Thr Gly  Thr Cys Ala 
    2735                 2740                 2745             


Gly Ala  Cys Cys Ala Ala Gly  Thr Thr Thr Ala Cys  Thr Cys Ala 
    2750                 2755                 2760             


Thr Ala  Thr Ala Thr Ala Cys  Thr Thr Thr Ala Gly  Ala Thr Thr 
    2765                 2770                 2775             


Gly Ala  Thr Thr Thr Ala Ala  Ala Ala Cys Thr Thr  Cys Ala Thr 
    2780                 2785                 2790             


Thr Thr  Thr Thr Ala Ala Thr  Thr Thr Ala Ala Ala  Ala Gly Gly 
    2795                 2800                 2805             


Ala Thr  Cys Thr Ala Gly Gly  Thr Gly Ala Ala Gly  Ala Thr Cys 
    2810                 2815                 2820             


Cys Thr  Thr Thr Thr Thr Gly  Ala Thr Ala Ala Thr  Cys Thr Cys 
    2825                 2830                 2835             


Ala Thr  Gly Ala Cys Cys Ala  Ala Ala Ala Thr Cys  Cys Cys Thr 
    2840                 2845                 2850             


Thr Ala  Ala Cys Gly Thr Gly  Ala Gly Thr Thr Thr  Thr Cys Gly 
    2855                 2860                 2865             


Thr Thr  Cys Cys Ala Cys Thr  Gly Ala Gly Cys Gly  Thr Cys Ala 
    2870                 2875                 2880             


Gly Ala  Cys Cys Cys Cys Gly  Thr Ala Gly Ala Ala  Ala Ala Gly 
    2885                 2890                 2895             


Ala Thr  Cys Ala Ala Ala Gly  Gly Ala Thr Cys Thr  Thr Cys Thr 
    2900                 2905                 2910             


Thr Gly  Ala Gly Ala Thr Cys  Cys Thr Thr Thr Thr  Thr Thr Thr 
    2915                 2920                 2925             


Cys Thr  Gly Cys Gly Cys Gly  Thr Ala Ala Thr Cys  Thr Gly Cys 
    2930                 2935                 2940             


Thr Gly  Cys Thr Thr Gly Cys  Ala Ala Ala Cys Ala  Ala Ala Ala 
    2945                 2950                 2955             


Ala Ala  Ala Cys Cys Ala Cys  Cys Gly Cys Thr Ala  Cys Cys Ala 
    2960                 2965                 2970             


Gly Cys  Gly Gly Thr Gly Gly  Thr Thr Thr Gly Thr  Thr Thr Gly 
    2975                 2980                 2985             


Cys Cys  Gly Gly Ala Thr Cys  Ala Ala Gly Ala Gly  Cys Thr Ala 
    2990                 2995                 3000             


Cys Cys  Ala Ala Cys Thr Cys  Thr Thr Thr Thr Thr  Cys Cys Gly 
    3005                 3010                 3015             


Ala Ala  Gly Gly Thr Ala Ala  Cys Thr Gly Gly Cys  Thr Thr Cys 
    3020                 3025                 3030             


Ala Gly  Cys Ala Gly Ala Gly  Cys Gly Cys Ala Gly  Ala Thr Ala 
    3035                 3040                 3045             


Cys Cys  Ala Ala Ala Thr Ala  Cys Thr Gly Thr Cys  Cys Thr Thr 
    3050                 3055                 3060             


Cys Thr  Ala Gly Thr Gly Thr  Ala Gly Cys Cys Gly  Thr Ala Gly 
    3065                 3070                 3075             


Thr Thr  Ala Gly Gly Cys Cys  Ala Cys Cys Ala Cys  Thr Thr Cys 
    3080                 3085                 3090             


Ala Ala  Gly Ala Ala Cys Thr  Cys Thr Gly Thr Ala  Gly Cys Ala 
    3095                 3100                 3105             


Cys Cys  Gly Cys Cys Thr Ala  Cys Ala Thr Ala Cys  Cys Thr Cys 
    3110                 3115                 3120             


Gly Cys  Thr Cys Thr Gly Cys  Thr Ala Ala Thr Cys  Cys Thr Gly 
    3125                 3130                 3135             


Thr Thr  Ala Cys Cys Ala Gly  Thr Gly Gly Cys Thr  Gly Cys Thr 
    3140                 3145                 3150             


Gly Cys  Cys Ala Gly Thr Gly  Gly Cys Gly Ala Thr  Ala Ala Gly 
    3155                 3160                 3165             


Thr Cys  Gly Thr Gly Thr Cys  Thr Thr Ala Cys Cys  Gly Gly Gly 
    3170                 3175                 3180             


Thr Thr  Gly Gly Ala Cys Thr  Cys Ala Ala Gly Ala  Cys Gly Ala 
    3185                 3190                 3195             


Thr Ala  Gly Thr Thr Ala Cys  Cys Gly Gly Ala Thr  Ala Ala Gly 
    3200                 3205                 3210             


Gly Cys  Gly Cys Ala Gly Cys  Gly Gly Thr Cys Gly  Gly Gly Cys 
    3215                 3220                 3225             


Thr Gly  Ala Ala Cys Gly Gly  Gly Gly Gly Gly Thr  Thr Cys Gly 
    3230                 3235                 3240             


Thr Gly  Cys Ala Cys Ala Cys  Ala Gly Cys Cys Cys  Ala Gly Cys 
    3245                 3250                 3255             


Thr Thr  Gly Gly Ala Gly Cys  Gly Ala Ala Cys Gly  Ala Cys Cys 
    3260                 3265                 3270             


Thr Ala  Cys Ala Cys Cys Gly  Ala Ala Cys Thr Gly  Ala Gly Ala 
    3275                 3280                 3285             


Thr Ala  Cys Cys Thr Ala Cys  Ala Gly Cys Gly Thr  Gly Ala Gly 
    3290                 3295                 3300             


Cys Thr  Ala Thr Gly Ala Gly  Ala Ala Ala Gly Cys  Gly Cys Cys 
    3305                 3310                 3315             


Ala Cys  Gly Cys Thr Thr Cys  Cys Cys Gly Ala Ala  Gly Gly Gly 
    3320                 3325                 3330             


Ala Gly  Ala Ala Ala Gly Gly  Cys Gly Gly Ala Cys  Ala Gly Gly 
    3335                 3340                 3345             


Thr Ala  Thr Cys Cys Gly Gly  Thr Ala Ala Gly Cys  Gly Gly Cys 
    3350                 3355                 3360             


Ala Gly  Gly Gly Thr Cys Gly  Gly Ala Ala Cys Ala  Gly Gly Ala 
    3365                 3370                 3375             


Gly Ala  Gly Cys Gly Cys Ala  Cys Gly Ala Gly Gly  Gly Ala Gly 
    3380                 3385                 3390             


Cys Thr  Thr Cys Cys Ala Gly  Gly Gly Gly Gly Ala  Ala Ala Cys 
    3395                 3400                 3405             


Gly Cys  Cys Thr Gly Gly Thr  Ala Thr Cys Thr Thr  Thr Ala Thr 
    3410                 3415                 3420             


Ala Gly  Thr Cys Cys Thr Gly  Thr Cys Gly Gly Gly  Thr Thr Thr 
    3425                 3430                 3435             


Cys Gly  Cys Cys Ala Cys Cys  Thr Cys Thr Gly Ala  Cys Thr Thr 
    3440                 3445                 3450             


Gly Ala  Gly Cys Gly Thr Cys  Gly Ala Thr Thr Thr  Thr Thr Gly 
    3455                 3460                 3465             


Thr Gly  Ala Thr Gly Cys Thr  Cys Gly Thr Cys Ala  Gly Gly Gly 
    3470                 3475                 3480             


Gly Gly  Gly Cys Gly Gly Ala  Gly Cys Cys Thr Ala  Thr Gly Gly 
    3485                 3490                 3495             


Ala Ala  Ala Ala Ala Cys Gly  Cys Cys Ala Gly Cys  Ala Ala Cys 
    3500                 3505                 3510             


Gly Cys  Gly Gly Cys Cys Thr  Thr Thr Thr Thr Ala  Cys Gly Gly 
    3515                 3520                 3525             


Thr Thr  Cys Cys Thr Gly Gly  Cys Cys Thr Thr Thr  Thr Gly Cys 
    3530                 3535                 3540             


Thr Gly  Gly Cys Cys Thr Thr  Thr Thr Gly Cys Thr  Cys Ala Cys 
    3545                 3550                 3555             


Ala Thr  Gly Thr Thr Cys Thr  Thr Thr Cys Cys Thr  Gly Cys Gly 
    3560                 3565                 3570             


Thr Thr  Ala Thr Cys Cys Cys  Cys Thr Gly Ala Thr  Thr Cys Thr 
    3575                 3580                 3585             


Gly Thr  Gly Gly Ala Thr Ala  Ala Cys Cys Gly Thr  Ala Thr Thr 
    3590                 3595                 3600             


Ala Cys  Cys Gly Cys Cys Thr  Thr Thr Gly Ala Gly  Thr Gly Ala 
    3605                 3610                 3615             


Gly Cys  Thr Gly Ala Thr Ala  Cys Cys Gly Cys Thr  Cys Gly Cys 
    3620                 3625                 3630             


Cys Gly  Cys Ala Gly Cys Cys  Gly Ala Ala Cys Gly  Ala Cys Cys 
    3635                 3640                 3645             


Gly Ala  Gly Cys Gly Cys Ala  Gly Cys Gly Ala Gly  Thr Cys Ala 
    3650                 3655                 3660             


Gly Thr  Gly Ala Gly Cys Gly  Ala Gly Gly Ala Ala  Gly Cys Gly 
    3665                 3670                 3675             


Gly Ala  Ala Gly Ala Gly Cys  Gly Cys Cys Thr Gly  Ala Thr Gly 
    3680                 3685                 3690             


Cys Gly  Gly Thr Ala Thr Thr  Thr Thr Cys Thr Cys  Cys Thr Thr 
    3695                 3700                 3705             


Ala Cys  Gly Cys Ala Thr Cys  Thr Gly Thr Gly Cys  Gly Gly Thr 
    3710                 3715                 3720             


Ala Thr  Thr Thr Cys Ala Cys  Ala Cys Cys Gly Cys  Ala Thr Ala 
    3725                 3730                 3735             


Ala Ala  Thr Thr Cys Cys Gly  Ala Cys Ala Cys Cys  Ala Thr Cys 
    3740                 3745                 3750             


Gly Ala  Ala Thr Gly Gly Thr  Gly Cys Ala Ala Ala  Ala Cys Cys 
    3755                 3760                 3765             


Thr Thr  Thr Cys Gly Cys Gly  Gly Thr Ala Thr Gly  Gly Cys Ala 
    3770                 3775                 3780             


Thr Gly  Ala Thr Ala Gly Cys  Gly Cys Cys Cys Gly  Gly Ala Ala 
    3785                 3790                 3795             


Gly Ala  Gly Ala Gly Thr Cys  Ala Ala Thr Thr Cys  Ala Gly Gly 
    3800                 3805                 3810             


Gly Thr  Gly Gly Thr Gly Ala  Ala Thr Gly Thr Gly  Ala Ala Ala 
    3815                 3820                 3825             


Cys Cys  Ala Gly Thr Ala Ala  Cys Gly Thr Thr Ala  Thr Ala Cys 
    3830                 3835                 3840             


Gly Ala  Thr Gly Thr Cys Gly  Cys Ala Gly Ala Gly  Thr Ala Thr 
    3845                 3850                 3855             


Gly Cys  Cys Gly Gly Thr Gly  Thr Cys Thr Cys Thr  Thr Ala Thr 
    3860                 3865                 3870             


Cys Ala  Gly Ala Cys Cys Gly  Thr Thr Thr Cys Cys  Cys Gly Cys 
    3875                 3880                 3885             


Gly Thr  Gly Gly Thr Gly Ala  Ala Cys Cys Ala Gly  Gly Cys Cys 
    3890                 3895                 3900             


Ala Gly  Cys Cys Ala Cys Gly  Thr Thr Thr Cys Thr  Gly Cys Gly 
    3905                 3910                 3915             


Ala Ala  Ala Ala Cys Gly Cys  Gly Gly Gly Ala Ala  Ala Ala Ala 
    3920                 3925                 3930             


Gly Thr  Gly Gly Ala Ala Gly  Cys Gly Gly Cys Gly  Ala Thr Gly 
    3935                 3940                 3945             


Gly Cys  Gly Gly Ala Gly Cys  Thr Gly Ala Ala Thr  Thr Ala Cys 
    3950                 3955                 3960             


Ala Thr  Thr Cys Cys Cys Ala  Ala Cys Cys Gly Cys  Gly Thr Gly 
    3965                 3970                 3975             


Gly Cys  Ala Cys Ala Ala Cys  Ala Ala Cys Thr Gly  Gly Cys Gly 
    3980                 3985                 3990             


Gly Gly  Cys Ala Ala Ala Cys  Ala Gly Thr Cys Gly  Thr Thr Gly 
    3995                 4000                 4005             


Cys Thr  Gly Ala Thr Thr Gly  Gly Cys Gly Thr Thr  Gly Cys Cys 
    4010                 4015                 4020             


Ala Cys  Cys Thr Cys Cys Ala  Gly Thr Cys Thr Gly  Gly Cys Cys 
    4025                 4030                 4035             


Cys Thr  Gly Cys Ala Cys Gly  Cys Gly Cys Cys Gly  Thr Cys Gly 
    4040                 4045                 4050             


Cys Ala  Ala Ala Thr Thr Gly  Thr Cys Gly Cys Gly  Gly Cys Gly 
    4055                 4060                 4065             


Ala Thr  Thr Ala Ala Ala Thr  Cys Thr Cys Gly Cys  Gly Cys Cys 
    4070                 4075                 4080             


Gly Ala  Thr Cys Ala Ala Cys  Thr Gly Gly Gly Thr  Gly Cys Cys 
    4085                 4090                 4095             


Ala Gly  Cys Gly Thr Gly Gly  Thr Gly Gly Thr Gly  Thr Cys Gly 
    4100                 4105                 4110             


Ala Thr  Gly Gly Thr Ala Gly  Ala Ala Cys Gly Ala  Ala Gly Cys 
    4115                 4120                 4125             


Gly Gly  Cys Gly Thr Cys Gly  Ala Ala Gly Cys Cys  Thr Gly Thr 
    4130                 4135                 4140             


Ala Ala  Ala Gly Cys Gly Gly  Cys Gly Gly Thr Gly  Cys Ala Cys 
    4145                 4150                 4155             


Ala Ala  Thr Cys Thr Thr Cys  Thr Cys Gly Cys Gly  Cys Ala Ala 
    4160                 4165                 4170             


Cys Gly  Cys Gly Thr Cys Ala  Gly Thr Gly Gly Gly  Cys Thr Gly 
    4175                 4180                 4185             


Ala Thr  Cys Ala Thr Thr Ala  Ala Cys Thr Ala Thr  Cys Cys Gly 
    4190                 4195                 4200             


Cys Thr  Gly Gly Ala Thr Gly  Ala Cys Cys Ala Gly  Gly Ala Thr 
    4205                 4210                 4215             


Gly Cys  Cys Ala Thr Thr Gly  Cys Thr Gly Thr Gly  Gly Ala Ala 
    4220                 4225                 4230             


Gly Cys  Thr Gly Cys Cys Thr  Gly Cys Ala Cys Thr  Ala Ala Thr 
    4235                 4240                 4245             


Gly Thr  Thr Cys Cys Gly Gly  Cys Gly Thr Thr Ala  Thr Thr Thr 
    4250                 4255                 4260             


Cys Thr  Thr Gly Ala Thr Gly  Thr Cys Thr Cys Thr  Gly Ala Cys 
    4265                 4270                 4275             


Cys Ala  Gly Ala Cys Ala Cys  Cys Cys Ala Thr Cys  Ala Ala Cys 
    4280                 4285                 4290             


Ala Gly  Thr Ala Thr Thr Ala  Thr Thr Thr Thr Cys  Thr Cys Cys 
    4295                 4300                 4305             


Cys Ala  Thr Gly Ala Ala Gly  Ala Cys Gly Gly Thr  Ala Cys Gly 
    4310                 4315                 4320             


Cys Gly  Ala Cys Thr Gly Gly  Gly Cys Gly Thr Gly  Gly Ala Gly 
    4325                 4330                 4335             


Cys Ala  Thr Cys Thr Gly Gly  Thr Cys Gly Cys Ala  Thr Thr Gly 
    4340                 4345                 4350             


Gly Gly  Thr Cys Ala Cys Cys  Ala Gly Cys Ala Ala  Ala Thr Cys 
    4355                 4360                 4365             


Gly Cys  Gly Cys Thr Gly Thr  Thr Ala Gly Cys Gly  Gly Gly Cys 
    4370                 4375                 4380             


Cys Cys  Ala Thr Thr Ala Ala  Gly Thr Thr Cys Thr  Gly Thr Cys 
    4385                 4390                 4395             


Thr Cys  Gly Gly Cys Gly Cys  Gly Thr Cys Thr Gly  Cys Gly Thr 
    4400                 4405                 4410             


Cys Thr  Gly Gly Cys Thr Gly  Gly Cys Thr Gly Gly  Cys Ala Thr 
    4415                 4420                 4425             


Ala Ala  Ala Thr Ala Thr Cys  Thr Cys Ala Cys Thr  Cys Gly Cys 
    4430                 4435                 4440             


Ala Ala  Thr Cys Ala Ala Ala  Thr Thr Cys Ala Gly  Cys Cys Gly 
    4445                 4450                 4455             


Ala Thr  Ala Gly Cys Gly Gly  Ala Ala Cys Gly Gly  Gly Ala Ala 
    4460                 4465                 4470             


Gly Gly  Cys Gly Ala Cys Thr  Gly Gly Ala Gly Thr  Gly Cys Cys 
    4475                 4480                 4485             


Ala Thr  Gly Thr Cys Cys Gly  Gly Thr Thr Thr Thr  Cys Ala Ala 
    4490                 4495                 4500             


Cys Ala  Ala Ala Cys Cys Ala  Thr Gly Cys Ala Ala  Ala Thr Gly 
    4505                 4510                 4515             


Cys Thr  Gly Ala Ala Thr Gly  Ala Gly Gly Gly Cys  Ala Thr Cys 
    4520                 4525                 4530             


Gly Thr  Thr Cys Cys Cys Ala  Cys Thr Gly Cys Gly  Ala Thr Gly 
    4535                 4540                 4545             


Cys Thr  Gly Gly Thr Thr Gly  Cys Cys Ala Ala Cys  Gly Ala Thr 
    4550                 4555                 4560             


Cys Ala  Gly Ala Thr Gly Gly  Cys Gly Cys Thr Gly  Gly Gly Cys 
    4565                 4570                 4575             


Gly Cys  Ala Ala Thr Gly Cys  Gly Cys Gly Cys Cys  Ala Thr Thr 
    4580                 4585                 4590             


Ala Cys  Cys Gly Ala Gly Thr  Cys Cys Gly Gly Gly  Cys Thr Gly 
    4595                 4600                 4605             


Cys Gly  Cys Gly Thr Thr Gly  Gly Thr Gly Cys Gly  Gly Ala Thr 
    4610                 4615                 4620             


Ala Thr  Cys Thr Cys Gly Gly  Thr Ala Gly Thr Gly  Gly Gly Ala 
    4625                 4630                 4635             


Thr Ala  Cys Gly Ala Cys Gly  Ala Thr Ala Cys Cys  Gly Ala Ala 
    4640                 4645                 4650             


Gly Ala  Cys Ala Gly Cys Thr  Cys Ala Thr Gly Thr  Thr Ala Thr 
    4655                 4660                 4665             


Ala Thr  Cys Cys Cys Gly Cys  Cys Gly Thr Thr Ala  Ala Cys Cys 
    4670                 4675                 4680             


Ala Cys  Cys Ala Thr Cys Ala  Ala Ala Cys Ala Gly  Gly Ala Thr 
    4685                 4690                 4695             


Thr Thr  Thr Cys Gly Cys Cys  Thr Gly Cys Thr Gly  Gly Gly Gly 
    4700                 4705                 4710             


Cys Ala  Ala Ala Cys Cys Ala  Gly Cys Gly Thr Gly  Gly Ala Cys 
    4715                 4720                 4725             


Cys Gly  Cys Thr Thr Gly Cys  Thr Gly Cys Ala Ala  Cys Thr Cys 
    4730                 4735                 4740             


Thr Cys  Thr Cys Ala Gly Gly  Gly Cys Cys Ala Gly  Gly Cys Gly 
    4745                 4750                 4755             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Ala Ala Thr  Cys Ala Gly 
    4760                 4765                 4770             


Cys Thr  Gly Thr Thr Gly Cys  Cys Cys Gly Thr Cys  Thr Cys Ala 
    4775                 4780                 4785             


Cys Thr  Gly Gly Thr Gly Ala  Ala Ala Ala Gly Ala  Ala Ala Ala 
    4790                 4795                 4800             


Ala Cys  Cys Ala Cys Cys Cys  Thr Gly Gly Cys Gly  Cys Cys Cys 
    4805                 4810                 4815             


Ala Ala  Thr Ala Cys Gly Cys  Ala Ala Ala Cys Cys  Gly Cys Cys 
    4820                 4825                 4830             


Thr Cys  Thr Cys Cys Cys Cys  Gly Cys Gly Cys Gly  Thr Thr Gly 
    4835                 4840                 4845             


Gly Cys  Cys Gly Ala Thr Thr  Cys Ala Thr Thr Ala  Ala Thr Gly 
    4850                 4855                 4860             


Cys Ala  Gly Cys Thr Gly Gly  Cys Ala Cys Gly Ala  Cys Ala Gly 
    4865                 4870                 4875             


Gly Thr  Thr Thr Cys Cys Cys  Gly Ala Cys Thr Gly  Gly Ala Ala 
    4880                 4885                 4890             


Ala Gly  Cys Gly Gly Gly Cys  Ala Gly Thr Gly Ala  Gly Cys Gly 
    4895                 4900                 4905             


Cys Ala  Ala Cys Gly Cys Ala  Ala Thr Thr Ala Ala  Thr Gly Thr 
    4910                 4915                 4920             


Gly Ala  Gly Thr Thr Ala Gly  Cys Thr Cys Ala Cys  Thr Cys Ala 
    4925                 4930                 4935             


Thr Thr  Ala Gly Gly Cys Ala  Cys Cys Cys Cys Ala  Gly Gly Cys 
    4940                 4945                 4950             


Thr Thr  Thr Ala Cys Ala Cys  Thr Thr Thr Ala Thr  Gly Cys Thr 
    4955                 4960                 4965             


Thr Cys  Cys Gly Gly Cys Thr  Cys Gly Thr Ala Thr  Gly Thr Thr 
    4970                 4975                 4980             


Gly Thr  Gly Thr Gly Gly Ala  Ala Thr Thr Gly Thr  Gly Ala Gly 
    4985                 4990                 4995             


Cys Gly  Gly Ala Thr Ala Ala  Cys Ala Ala Thr Thr  Thr Cys Ala 
    5000                 5005                 5010             


Cys Ala  Cys Ala Gly Gly Ala  Ala Ala Cys Ala Gly  Cys Thr Ala 
    5015                 5020                 5025             


Thr Gly  Ala Cys Cys Ala Thr  Gly Ala Thr Thr Ala  Cys Gly Gly 
    5030                 5035                 5040             


Ala Thr  Thr Cys Ala Cys Thr  Gly Gly Cys Cys Gly  Thr Cys Gly 
    5045                 5050                 5055             


Thr Thr  Thr Thr Ala Cys Ala  Ala Cys Gly Thr Cys  Gly Thr Gly 
    5060                 5065                 5070             


Ala Cys  Thr Gly Gly Gly Ala  Ala Ala Ala Cys Cys  Cys Thr Gly 
    5075                 5080                 5085             


Gly Cys  Gly Thr Thr Ala Cys  Cys Cys Ala Ala Cys  Thr Thr Ala 
    5090                 5095                 5100             


Ala Thr  Cys Gly Cys Cys Thr  Thr Gly Cys Ala Gly  Cys Ala Cys 
    5105                 5110                 5115             


Ala Thr  Cys Cys Cys Cys Cys  Thr Thr Thr Cys Gly  Cys Cys Ala 
    5120                 5125                 5130             


Gly Cys  Thr Gly Gly Cys Gly  Thr Ala Ala Thr Ala  Gly Cys Gly 
    5135                 5140                 5145             


Ala Ala  Gly Ala Gly Gly Cys  Cys Cys Gly Cys Ala  Cys Cys Gly 
    5150                 5155                 5160             


Ala Thr  Cys Gly Cys Cys Cys  Thr Thr Cys Cys Cys  Ala Ala Cys 
    5165                 5170                 5175             


Ala Gly  Thr Thr Gly Cys Gly  Cys Ala Gly Cys Cys  Thr Gly Ala 
    5180                 5185                 5190             


Ala Thr  Gly Gly Cys Gly Ala  Ala Thr Gly Gly Cys  Gly Cys Thr 
    5195                 5200                 5205             


Thr Thr  Gly Cys Cys Thr Gly  Gly Thr Thr Thr Cys  Cys Gly Gly 
    5210                 5215                 5220             


Cys Ala  Cys Cys Ala Gly Ala  Ala Gly Cys Gly Gly  Thr Gly Cys 
    5225                 5230                 5235             


Cys Gly  Gly Ala Ala Ala Gly  Cys Thr Gly Gly Cys  Thr Gly Gly 
    5240                 5245                 5250             


Ala Gly  Thr Gly Cys Gly Ala  Thr Cys Thr Thr Cys  Cys Thr Gly 
    5255                 5260                 5265             


Ala Gly  Gly Cys Cys Gly Ala  Thr Ala Cys Thr Gly  Thr Cys Gly 
    5270                 5275                 5280             


Thr Cys  Gly Thr Cys Cys Cys  Cys Thr Cys Ala Ala  Ala Cys Thr 
    5285                 5290                 5295             


Gly Gly  Cys Ala Gly Ala Thr  Gly Cys Ala Cys Gly  Gly Thr Thr 
    5300                 5305                 5310             


Ala Cys  Gly Ala Thr Gly Cys  Gly Cys Cys Cys Ala  Thr Cys Thr 
    5315                 5320                 5325             


Ala Cys  Ala Cys Cys Ala Ala  Cys Gly Thr Ala Ala  Cys Cys Thr 
    5330                 5335                 5340             


Ala Thr  Cys Cys Cys Ala Thr  Thr Ala Cys Gly Gly  Thr Cys Ala 
    5345                 5350                 5355             


Ala Thr  Cys Cys Gly Cys Cys  Gly Thr Thr Thr Gly  Thr Thr Cys 
    5360                 5365                 5370             


Cys Cys  Ala Cys Gly Gly Ala  Gly Ala Ala Thr Cys  Cys Gly Ala 
    5375                 5380                 5385             


Cys Gly  Gly Gly Thr Thr Gly  Thr Thr Ala Cys Thr  Cys Gly Cys 
    5390                 5395                 5400             


Thr Cys  Ala Cys Ala Thr Thr  Thr Ala Ala Thr Gly  Thr Thr Gly 
    5405                 5410                 5415             


Ala Thr  Gly Ala Ala Ala Gly  Cys Thr Gly Gly Cys  Thr Ala Cys 
    5420                 5425                 5430             


Ala Gly  Gly Ala Ala Gly Gly  Cys Cys Ala Gly Ala  Cys Gly Cys 
    5435                 5440                 5445             


Gly Ala  Ala Thr Thr Ala Thr  Thr Thr Thr Thr Gly  Ala Thr Gly 
    5450                 5455                 5460             


Gly Cys  Gly Thr Thr Gly Gly  Ala Ala Thr Thr 
    5465                 5470                 


<210>  13
<211>  6806
<212>  DNA
<213>  artificial sequence

<220>
<223>  construct 1


<220>
<221>  pGex-L1-delta N10-delta h4-delta C29-p16INK4a
<222>  (1)..(6806)
<223>  contains the full-length human p16INK4a gene fused to the 
       C-terminus of the modified L1

<400>  13
acgttatcga ctgcacggtg caccaatgct tctggcgtca ggcagccatc ggaagctgtg       60

gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc gcactcccgt      120

tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc tgaaatgagc      180

tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat aacaatttca      240

cacaggaaac agtattcatg tcccctatac taggttattg gaaaattaag ggccttgtgc      300

aacccactcg acttcttttg gaatatcttg aagaaaaata tgaagagcat ttgtatgagc      360

gcgatgaagg tgataaatgg cgaaacaaaa agtttgaatt gggtttggag tttcccaatc      420

ttccttatta tattgatggt gatgttaaat taacacagtc tatggccatc atacgttata      480

tagctgacaa gcacaacatg ttgggtggtt gtccaaaaga gcgtgcagag atttcaatgc      540

ttgaaggagc ggttttggat attagatacg gtgtttcgag aattgcatat agtaaagact      600

ttgaaactct caaagttgat tttcttagca agctacctga aatgctgaaa atgttcgaag      660

atcgtttatg tcataaaaca tatttaaatg gtgatcatgt aacccatcct gacttcatgt      720

tgtatgacgc tcttgatgtt gttttataca tggacccaat gtgcctggat gcgttcccaa      780

aattagtttg ttttaaaaaa cgtattgaag ctatcccaca aattgataag tacttgaaat      840

ccagcaagta tatagcatgg cctttgcagg gctggcaagc cacgtttggt ggtggcgacc      900

atcctccaaa atcggatctg gttccgcgtg gatccgtcta cttgcctcct gtcccagtat      960

ctaaggttgt aagcacggat gaatatgttg cacgcacaaa catatattat catgcaggaa     1020

catccagact acttgcagtt ggacatccct attttcctat taaaaaacct aacaataaca     1080

aaatattagt tcctaaagta tcaggattac aatacagggt atttagaata catttacctg     1140

accccaataa gtttggtttt cctgacacct cattttataa tccagataca cagcggctgg     1200

tttgggcctg tgtaggtgtt gaggtaggtc gtggtcagcc attaggtgtg ggcattagtg     1260

gccatccttt attaaataaa ttggatgaca cagaaaatgc tagtgcttat gcagcaaatg     1320

caggtgtgga taatagagaa tgtatatcta tggattacaa acaaacacaa ttgtgtttaa     1380

ttggttgcaa accacctata ggggaacact ggggcaaagg ctccccatgt accaatgttg     1440

cagtaaatcc aggtgattgt ccaccattag agttaataaa cacagttatt caggatggtg     1500

atatggttga tactggcttt ggtgctatgg actttactac attacaggct aacaaaagtg     1560

aagttccact ggatatttgt acatctattt gcaaatatcc agattatatt aaaatggtgt     1620

cagaaccata tggcgacagc ttattttttt atttacgaag ggaacaaatg tttgttagac     1680

atttatttaa tagggctggt gctgttggtg aaaatgtacc agacgattta tacattaaag     1740

gctctgggtc tactgcaaat ttagccagtt caaattattt tcctacacct agtggttcta     1800

tggttacctc tgatgcccaa atattcaata aaccttattg gttacaacga gcacagggcc     1860

acaataatgg catttgttgg ggtaaccaac tatttgttac tgttgttgat actacacgca     1920

gtacaaatat gtcattatgt gctgccatat ctacttcaga aactacatat aaaaatacta     1980

actttaagga gtacctacga catggggagg aatatgattt acagtttatt tttcaactgt     2040

gcaaaataac cttaactgca gacgttatga catacataca ttctatgaat tccactattt     2100

tggaggactg gaattttggt ctacaaacac ctccagcacc taaagaagat ccccttaaaa     2160

aatacacttt ttgggaagta aatttaaagg aaaagttttc tgcagaccta gatcagtttc     2220

ctttaggacg caaattttta ctacaagcag gattgaaggc gatgcatatg gagccggcgg     2280

cggggagcag catggagcct tcggctgact ggctggccac ggccgcggcc cggggtcggg     2340

tagaggaggt gcgggcgctg ctggaggcgg gggcgctgcc caacgcaccg aatagttacg     2400

gtcggaggcc gatccaggtc atgatgatgg gcagcgcccg agtggcggag ctgctgctgc     2460

tccacggcgc ggagcccaac tgcgccgacc ccgccactct cacccgaccc gtgcacgacg     2520

ctgcccggga gggcttcctg gacacgctgg tggtgctgca ccgggccggg gcgcggctgg     2580

acgtgcgcga tgcctggggc cgtctgcccg tggacctggc tgaggagctg ggccatcgcg     2640

atgtcgcacg gtacctgcgc gcggctgcgg ggggcaccag aggcagtaac catgcccgca     2700

tagatgccgc ggaaggtccc tcagacatcc ccgattgaaa gcttatcgat accgtcgaca     2760

aacctcccac acctccccct gaacctgaaa cataagcggc cgcatcgtga ctgactgacg     2820

atctgcctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag     2880

acggtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca     2940

gcgggtgttg gcgggtgtcg gggcgcagcc atgacccagt cacgtagcga tagcggagtg     3000

tataattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     3060

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     3120

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     3180

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     3240

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     3300

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     3360

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     3420

tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc     3480

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     3540

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     3600

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     3660

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     3720

gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc     3780

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     3840

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     3900

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     3960

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     4020

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     4080

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     4140

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     4200

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     4260

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     4320

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     4380

ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     4440

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     4500

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     4560

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     4620

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     4680

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     4740

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     4800

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     4860

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     4920

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     4980

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc tgatgcggta ttttctcctt     5040

acgcatctgt gcggtatttc acaccgcata aattccgaca ccatcgaatg gtgcaaaacc     5100

tttcgcggta tggcatgata gcgcccggaa gagagtcaat tcagggtggt gaatgtgaaa     5160

ccagtaacgt tatacgatgt cgcagagtat gccggtgtct cttatcagac cgtttcccgc     5220

gtggtgaacc aggccagcca cgtttctgcg aaaacgcggg aaaaagtgga agcggcgatg     5280

gcggagctga attacattcc caaccgcgtg gcacaacaac tggcgggcaa acagtcgttg     5340

ctgattggcg ttgccacctc cagtctggcc ctgcacgcgc cgtcgcaaat tgtcgcggcg     5400

attaaatctc gcgccgatca actgggtgcc agcgtggtgg tgtcgatggt agaacgaagc     5460

ggcgtcgaag cctgtaaagc ggcggtgcac aatcttctcg cgcaacgcgt cagtgggctg     5520

atcattaact atccgctgga tgaccaggat gccattgctg tggaagctgc ctgcactaat     5580

gttccggcgt tatttcttga tgtctctgac cagacaccca tcaacagtat tattttctcc     5640

catgaagacg gtacgcgact gggcgtggag catctggtcg cattgggtca ccagcaaatc     5700

gcgctgttag cgggcccatt aagttctgtc tcggcgcgtc tgcgtctggc tggctggcat     5760

aaatatctca ctcgcaatca aattcagccg atagcggaac gggaaggcga ctggagtgcc     5820

atgtccggtt ttcaacaaac catgcaaatg ctgaatgagg gcatcgttcc cactgcgatg     5880

ctggttgcca acgatcagat ggcgctgggc gcaatgcgcg ccattaccga gtccgggctg     5940

cgcgttggtg cggatatctc ggtagtggga tacgacgata ccgaagacag ctcatgttat     6000

atcccgccgt taaccaccat caaacaggat tttcgcctgc tggggcaaac cagcgtggac     6060

cgcttgctgc aactctctca gggccaggcg gtgaagggca atcagctgtt gcccgtctca     6120

ctggtgaaaa gaaaaaccac cctggcgccc aatacgcaaa ccgcctctcc ccgcgcgttg     6180

gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg     6240

caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct     6300

tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta     6360

tgaccatgat tacggattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     6420

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     6480

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgct     6540

ttgcctggtt tccggcacca gaagcggtgc cggaaagctg gctggagtgc gatcttcctg     6600

aggccgatac tgtcgtcgtc ccctcaaact ggcagatgca cggttacgat gcgcccatct     6660

acaccaacgt aacctatccc attacggtca atccgccgtt tgttcccacg gagaatccga     6720

cgggttgtta ctcgctcaca tttaatgttg atgaaagctg gctacaggaa ggccagacgc     6780

gaattatttt tgatggcgtt ggaatt                                          6806


<210>  14
<211>  6800
<212>  DNA
<213>  artificial sequence

<220>
<223>  construct 2


<220>
<221>  pGex-p16INK4a-L1 delta N10-delta h4-delta C29
<222>  (1)..(6800)
<223>  contains the full-length human p16INK4a gene fused to the 
       N-terminus of the modified L1

<400>  14
acgttatcga ctgcacggtg caccaatgct tctggcgtca ggcagccatc ggaagctgtg       60

gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc gcactcccgt      120

tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc tgaaatgagc      180

tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat aacaatttca      240

cacaggaaac agtattcatg tcccctatac taggttattg gaaaattaag ggccttgtgc      300

aacccactcg acttcttttg gaatatcttg aagaaaaata tgaagagcat ttgtatgagc      360

gcgatgaagg tgataaatgg cgaaacaaaa agtttgaatt gggtttggag tttcccaatc      420

ttccttatta tattgatggt gatgttaaat taacacagtc tatggccatc atacgttata      480

tagctgacaa gcacaacatg ttgggtggtt gtccaaaaga gcgtgcagag atttcaatgc      540

ttgaaggagc ggttttggat attagatacg gtgtttcgag aattgcatat agtaaagact      600

ttgaaactct caaagttgat tttcttagca agctacctga aatgctgaaa atgttcgaag      660

atcgtttatg tcataaaaca tatttaaatg gtgatcatgt aacccatcct gacttcatgt      720

tgtatgacgc tcttgatgtt gttttataca tggacccaat gtgcctggat gcgttcccaa      780

aattagtttg ttttaaaaaa cgtattgaag ctatcccaca aattgataag tacttgaaat      840

ccagcaagta tatagcatgg cctttgcagg gctggcaagc cacgtttggt ggtggcgacc      900

atcctccaaa atcggatctg gttccgcgtg gatccatgga gccggcggcg gggagcagca      960

tggagccttc ggctgactgg ctggccacgg ccgcggcccg gggtcgggta gaggaggtgc     1020

gggcgctgct ggaggcgggg gcgctgccca acgcaccgaa tagttacggt cggaggccga     1080

tccaggtcat gatgatgggc agcgcccgag tggcggagct gctgctgctc cacggcgcgg     1140

agcccaactg cgccgacccc gccactctca cccgacccgt gcacgacgct gcccgggagg     1200

gcttcctgga cacgctggtg gtgctgcacc gggccggggc gcggctggac gtgcgcgatg     1260

cctggggccg tctgcccgtg gacctggctg aggagctggg ccatcgcgat gtcgcacggt     1320

acctgcgcgc ggctgcgggg ggcaccagag gcagtaacca tgcccgcata gatgccgcgg     1380

aaggtccctc agacatcccc gatgtctact tgcctcctgt cccagtatct aaggttgtaa     1440

gcacggatga atatgttgca cgcacaaaca tatattatca tgcaggaaca tccagactac     1500

ttgcagttgg acatccctat tttcctatta aaaaacctaa caataacaaa atattagttc     1560

ctaaagtatc aggattacaa tacagggtat ttagaataca tttacctgac cccaataagt     1620

ttggttttcc tgacacctca ttttataatc cagatacaca gcggctggtt tgggcctgtg     1680

taggtgttga ggtaggtcgt ggtcagccat taggtgtggg cattagtggc catcctttat     1740

taaataaatt ggatgacaca gaaaatgcta gtgcttatgc agcaaatgca ggtgtggata     1800

atagagaatg tatatctatg gattacaaac aaacacaatt gtgtttaatt ggttgcaaac     1860

cccctatagg ggaacactgg ggcaaaggct ccccatgtac caatgttgca gtaaatccag     1920

gtgattgtcc accattagag ttaataaaca cagttattca ggatggtgat atggttgata     1980

ctggctttgg tgctatggac tttactacat tacaggctaa caaaagtgaa gttccactgg     2040

atatttgtac atctatttgc aaatatccag attatattaa aatggtgtca gaaccatatg     2100

gcgacagctt atttttttat ttacgaaggg aacaaatgtt tgttagacat ttatttaata     2160

gggctggtgc tgttggtgaa aatgtaccag acgatttata cattaaaggc tctgggtcta     2220

ctgcaaattt agccagttca aattattttc ctacacctag tggttctatg gttacctctg     2280

atgcccaaat attcaataaa ccttattggt tacaacgagc acagggccac aataatggca     2340

tttgttgggg taaccaacta tttgttactg ttgttgatac tacacgcagt acaaatatgt     2400

cattatgtgc tgccatatct acttcagaaa ctacatataa aaatactaac tttaaggagt     2460

acctacgaca tggggaggaa tatgatttac agtttatttt tcaactgtgc aaaataacct     2520

taactgcaga cgttatgaca tacatacatt ctatgaattc cactattttg gaggactgga     2580

attttggtct acaaacacct ccagcaccta aagaagatcc ccttaaaaaa tacacttttt     2640

gggaagtaaa tttaaaggaa aagttttctg cagacctaga tcagtttcct ttaggacgca     2700

aatttttact acaagcagga ttgaaggcct aaaagcttat cgataccgtc gacaaacctc     2760

ccacacctcc ccctgaacct gaaacataag cggccgcatc gtgactgact gacgatctgc     2820

ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc     2880

acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt     2940

gttggcgggt gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtataat     3000

tcttgaagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     3060

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     3120

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     3180

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     3240

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     3300

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     3360

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     3420

gttctgctat gtggcgcggt attatcccgt gttgacgccg ggcaagagca actcggtcgc     3480

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     3540

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     3600

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     3660

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     3720

ccaaacgacg agcgtgacac cacgatgcct gcagcaatgg caacaacgtt gcgcaaacta     3780

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     3840

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     3900

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     3960

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     4020

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     4080

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     4140

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     4200

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     4260

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     4320

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     4380

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     4440

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     4500

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     4560

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     4620

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     4680

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     4740

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     4800

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     4860

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat     4920

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc     4980

agcgagtcag tgagcgagga agcggaagag cgcctgatgc ggtattttct ccttacgcat     5040

ctgtgcggta tttcacaccg cataaattcc gacaccatcg aatggtgcaa aacctttcgc     5100

ggtatggcat gatagcgccc ggaagagagt caattcaggg tggtgaatgt gaaaccagta     5160

acgttatacg atgtcgcaga gtatgccggt gtctcttatc agaccgtttc ccgcgtggtg     5220

aaccaggcca gccacgtttc tgcgaaaacg cgggaaaaag tggaagcggc gatggcggag     5280

ctgaattaca ttcccaaccg cgtggcacaa caactggcgg gcaaacagtc gttgctgatt     5340

ggcgttgcca cctccagtct ggccctgcac gcgccgtcgc aaattgtcgc ggcgattaaa     5400

tctcgcgccg atcaactggg tgccagcgtg gtggtgtcga tggtagaacg aagcggcgtc     5460

gaagcctgta aagcggcggt gcacaatctt ctcgcgcaac gcgtcagtgg gctgatcatt     5520

aactatccgc tggatgacca ggatgccatt gctgtggaag ctgcctgcac taatgttccg     5580

gcgttatttc ttgatgtctc tgaccagaca cccatcaaca gtattatttt ctcccatgaa     5640

gacggtacgc gactgggcgt ggagcatctg gtcgcattgg gtcaccagca aatcgcgctg     5700

ttagcgggcc cattaagttc tgtctcggcg cgtctgcgtc tggctggctg gcataaatat     5760

ctcactcgca atcaaattca gccgatagcg gaacgggaag gcgactggag tgccatgtcc     5820

ggttttcaac aaaccatgca aatgctgaat gagggcatcg ttcccactgc gatgctggtt     5880

gccaacgatc agatggcgct gggcgcaatg cgcgccatta ccgagtccgg gctgcgcgtt     5940

ggtgcggata tctcggtagt gggatacgac gataccgaag acagctcatg ttatatcccg     6000

ccgttaacca ccatcaaaca ggattttcgc ctgctggggc aaaccagcgt ggaccgcttg     6060

ctgcaactct ctcagggcca ggcggtgaag ggcaatcagc tgttgcccgt ctcactggtg     6120

aaaagaaaaa ccaccctggc gcccaatacg caaaccgcct ctccccgcgc gttggccgat     6180

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc     6240

aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc     6300

tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca     6360

tgattacgga ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta     6420

cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg     6480

cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgctttgcct     6540

ggtttccggc accagaagcg gtgccggaaa gctggctgga gtgcgatctt cctgaggccg     6600

atactgtcgt cgtcccctca aactggcaga tgcacggtta cgatgcgccc atctacacca     6660

acgtaaccta tcccattacg gtcaatccgc cgtttgttcc cacggagaat ccgacgggtt     6720

gttactcgct cacatttaat gttgatgaaa gctggctaca ggaaggccag acgcgaatta     6780

tttttgatgg cgttggaatt                                                 6800


<210>  15
<211>  6773
<212>  DNA
<213>  artificial sequence

<220>
<223>  construct 3


<220>
<221>  pGex-L1delta N10-delta h4-p16INK4a-L1delta C29
<222>  (1)..(6773)
<223>  contains the full-length human p16INK4a gene inserted at the 
       helix 4 position of the modified L1

<400>  15
acgttatcga ctgcacggtg caccaatgct tctggcgtca ggcagccatc ggaagctgtg       60

gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc gcactcccgt      120

tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc tgaaatgagc      180

tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat aacaatttca      240

cacaggaaac agtattcatg tcccctatac taggttattg gaaaattaag ggccttgtgc      300

aacccactcg acttcttttg gaatatcttg aagaaaaata tgaagagcat ttgtatgagc      360

gcgatgaagg tgataaatgg cgaaacaaaa agtttgaatt gggtttggag tttcccaatc      420

ttccttatta tattgatggt gatgttaaat taacacagtc tatggccatc atacgttata      480

tagctgacaa gcacaacatg ttgggtggtt gtccaaaaga gcgtgcagag atttcaatgc      540

ttgaaggagc ggttttggat attagatacg gtgtttcgag aattgcatat agtaaagact      600

ttgaaactct caaagttgat tttcttagca agctacctga aatgctgaaa atgttcgaag      660

atcgtttatg tcataaaaca tatttaaatg gtgatcatgt aacccatcct gacttcatgt      720

tgtatgacgc tcttgatgtt gttttataca tggacccaat gtgcctggat gcgttcccaa      780

aattagtttg ttttaaaaaa cgtattgaag ctatcccaca aattgataag tacttgaaat      840

ccagcaagta tatagcatgg cctttgcagg gctggcaagc cacgtttggt ggtggcgacc      900

atcctccaaa atcggatctg gttccgcgtg gatccgtcta cttgcctcct gtcccagtat      960

ctaaggttgt aagcacggat gaatatgttg cacgcacaaa catatattat catgcaggaa     1020

catccagact acttgcagtt ggacatccct attttcctat taaaaaacct aacaataaca     1080

aaatattagt tcctaaagta tcaggattac aatacagggt atttagaata catttacctg     1140

accccaataa gtttggtttt cctgacacct cattttataa tccagataca cagcggctgg     1200

tttgggcctg tgtaggtgtt gaggtaggtc gtggtcagcc attaggtgtg ggcattagtg     1260

gccatccttt attaaataaa ttggatgaca cagaaaatgc tagtgcttat gcagcaaatg     1320

caggtgtgga taatagagaa tgtatatcta tggattacaa acaaacacaa ttgtgtttaa     1380

ttggttgcaa accacctata ggggaacact ggggcaaagg ctccccatgt accaatgttg     1440

cagtaaatcc aggtgattgt ccaccattag agttaataaa cacagttatt caggatggtg     1500

atatggttga tactggcttt ggtgctatgg actttactac attacaggct aacaaaagtg     1560

aagttccact ggatatttgt acatctattt gcaaatatcc agattatatt aaaatggtgt     1620

cagaaccata tggcgacagc ttattttttt atttacgaag ggaacaaatg tttgttagac     1680

atttatttaa tagggctggt gctgttggtg aaaatgtacc agacgattta tacattaaag     1740

gctctgggtc tactgcaaat ttagccagtt caaattattt tcctacacct agtggttcta     1800

tggttacctc tgatgcccaa atattcaata aaccttattg gttacaacga gcacagggcc     1860

acaataatgg catttgttgg ggtaaccaac tatttgttac tgttgttgat actacacgca     1920

gtacaaatat gtcattatgt gctgccatat ctacttcaga aactacatat aaaaatacta     1980

actttaagga gtacctacga catggggagg aatatgattt acagtttatt tttcaactgt     2040

gcaaaataac cttaactgca gacgttatga catacataca ttctatgaat tccactattt     2100

tggaggactg gaatatggag ccggcggcgg ggagcagcat ggagccttcg gctgactggc     2160

tggccacggc cgcggcccgg ggtcgggtag aggaggtgcg ggcgctgctg gaggcggggg     2220

cgctgcccaa cgcaccgaat agttacggtc ggaggccgat ccaggtcatg atgatgggca     2280

gcgcccgagt ggcggagctg ctgctgctcc acggcgcgga gcccaactgc gccgaccccg     2340

ccactctcac ccgacccgtg cacgacgctg cccgggaggg cttcctggac acgctggtgg     2400

tgctgcaccg ggccggggcg cggctggacg tgcgcgatgc ctggggccgt ctgcccgtgg     2460

acctggctga ggagctgggc catcgcgatg tcgcacggta cctgcgcgcg gctgcggggg     2520

gcaccagagg cagtaaccat gcccgcatag atgccgcgga aggtccctca gacatccccg     2580

ataaagaaga tccccttaaa aaatacactt tttgggaagt aaatttaaag gaaaagtttt     2640

ctgcagacct agatcagttt cctttaggac gcaaattttt actacaagca ggattgaagg     2700

cgtaaaagct tatcgatacc gtcgacaaac ctcccacacc tccccctgaa cctgaaacat     2760

aagcggccgc atcgtgactg actgacgatc tgcctcgcgc gtttcggtga tgacggtgaa     2820

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     2880

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg     2940

acccagtcac gtagcgatag cggagtgtat aattcttgaa gacgaaaggg cctcgtgata     3000

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     3060

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     3120

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     3180

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     3240

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     3300

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     3360

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     3420

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     3480

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     3540

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     3600

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     3660

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3720

cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3780

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3840

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3900

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3960

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     4020

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     4080

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     4140

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     4200

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     4260

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     4320

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     4380

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     4440

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     4500

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     4560

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     4620

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     4680

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4740

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4800

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4860

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4920

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     4980

gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcataaat     5040

tccgacacca tcgaatggtg caaaaccttt cgcggtatgg catgatagcg cccggaagag     5100

agtcaattca gggtggtgaa tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc     5160

ggtgtctctt atcagaccgt ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa     5220

acgcgggaaa aagtggaagc ggcgatggcg gagctgaatt acattcccaa ccgcgtggca     5280

caacaactgg cgggcaaaca gtcgttgctg attggcgttg ccacctccag tctggccctg     5340

cacgcgccgt cgcaaattgt cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc     5400

gtggtggtgt cgatggtaga acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat     5460

cttctcgcgc aacgcgtcag tgggctgatc attaactatc cgctggatga ccaggatgcc     5520

attgctgtgg aagctgcctg cactaatgtt ccggcgttat ttcttgatgt ctctgaccag     5580

acacccatca acagtattat tttctcccat gaagacggta cgcgactggg cgtggagcat     5640

ctggtcgcat tgggtcacca gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg     5700

gcgcgtctgc gtctggctgg ctggcataaa tatctcactc gcaatcaaat tcagccgata     5760

gcggaacggg aaggcgactg gagtgccatg tccggttttc aacaaaccat gcaaatgctg     5820

aatgagggca tcgttcccac tgcgatgctg gttgccaacg atcagatggc gctgggcgca     5880

atgcgcgcca ttaccgagtc cgggctgcgc gttggtgcgg atatctcggt agtgggatac     5940

gacgataccg aagacagctc atgttatatc ccgccgttaa ccaccatcaa acaggatttt     6000

cgcctgctgg ggcaaaccag cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg     6060

aagggcaatc agctgttgcc cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat     6120

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     6180

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     6240

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     6300

ataacaattt cacacaggaa acagctatga ccatgattac ggattcactg gccgtcgttt     6360

tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc     6420

cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt     6480

tgcgcagcct gaatggcgaa tggcgctttg cctggtttcc ggcaccagaa gcggtgccgg     6540

aaagctggct ggagtgcgat cttcctgagg ccgatactgt cgtcgtcccc tcaaactggc     6600

agatgcacgg ttacgatgcg cccatctaca ccaacgtaac ctatcccatt acggtcaatc     6660

cgccgtttgt tcccacggag aatccgacgg gttgttactc gctcacattt aatgttgatg     6720

aaagctggct acaggaaggc cagacgcgaa ttatttttga tggcgttgga att            6773


<210>  16
<211>  500
<212>  PRT
<213>  Human papillomavirus type 6


<220>
<221>  L1 protein HPV 6
<222>  (1)..(500)

<400>  16

Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val Pro Pro Pro Asn Pro 
1               5                   10                  15      


Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val Thr Arg Thr Asn Ile 
            20                  25                  30          


Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala Val Gly His Pro Tyr 
        35                  40                  45              


Phe Ser Ile Lys Arg Ala Asn Lys Thr Val Val Pro Lys Val Ser Gly 
    50                  55                  60                  


Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro Asn Lys Phe 
65                  70                  75                  80  


Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln Arg Leu Val 
                85                  90                  95      


Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro Leu Gly Val 
            100                 105                 110         


Gly Val Ser Gly His Pro Phe Leu Asn Lys Tyr Asp Asp Val Glu Asn 
        115                 120                 125             


Ser Gly Ser Gly Gly Asn Pro Gly Gln Asp Asn Arg Val Asn Val Gly 
    130                 135                 140                 


Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly Cys Ala Pro Pro 
145                 150                 155                 160 


Leu Gly Glu His Trp Gly Lys Gly Lys Gln Cys Thr Asn Thr Pro Val 
                165                 170                 175     


Gln Ala Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr Ser Val Ile Gln 
            180                 185                 190         


Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met Asn Phe Ala Asp 
        195                 200                 205             


Leu Gln Thr Asn Lys Ser Asp Val Pro Ile Asp Ile Cys Gly Thr Thr 
    210                 215                 220                 


Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp Pro Tyr Gly Asp 
225                 230                 235                 240 


Arg Leu Phe Phe Phe Leu Arg Lys Glu Gln Met Phe Ala Arg His Phe 
                245                 250                 255     


Phe Asn Arg Ala Gly Glu Val Gly Glu Pro Val Pro Asp Thr Leu Ile 
            260                 265                 270         


Ile Lys Gly Ser Gly Asn Arg Thr Ser Val Gly Ser Ser Ile Tyr Val 
        275                 280                 285             


Asn Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala Gln Leu Phe Asn 
    290                 295                 300                 


Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn Asn Gly Ile Cys 
305                 310                 315                 320 


Trp Gly Asn Gln Leu Phe Val Thr Val Val Asp Thr Thr Arg Ser Thr 
                325                 330                 335     


Asn Met Thr Leu Cys Ala Ser Val Thr Thr Ser Ser Thr Tyr Thr Asn 
            340                 345                 350         


Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu Tyr Asp Leu Gln 
        355                 360                 365             


Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala Asp Val Met Ala 
    370                 375                 380                 


Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp Trp Asn Phe Gly 
385                 390                 395                 400 


Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr Tyr Arg Tyr Val 
                405                 410                 415     


Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro Glu Lys Glu Lys 
            420                 425                 430         


Pro Asp Pro Tyr Lys Asn Leu Ser Phe Trp Glu Val Asn Leu Lys Glu 
        435                 440                 445             


Lys Phe Ser Ser Glu Leu Asp Gln Tyr Pro Leu Gly Arg Lys Phe Leu 
    450                 455                 460                 


Leu Gln Ser Gly Tyr Arg Gly Arg Ser Ser Ile Arg Thr Gly Val Lys 
465                 470                 475                 480 


Arg Pro Ala Val Ser Lys Ala Ser Ala Ala Pro Lys Arg Lys Arg Ala 
                485                 490                 495     


Lys Thr Lys Arg 
            500 


<210>  17
<211>  531
<212>  PRT
<213>  Human papillomavirus type 10


<220>
<221>  L1 protein HPV 10
<222>  (1)..(531)

<400>  17

Met Ala Gly Ile Ser Ile Phe Gly Leu Leu Pro Phe Thr Ser Pro Asp 
1               5                   10                  15      


Ile Val Ala Val Asn Val Ser His Ile Phe Leu Gln Met Ala Leu Trp 
            20                  25                  30          


Arg Ser Ser Asp Asn Leu Val Tyr Leu Pro Pro Thr Pro Val Ser Lys 
        35                  40                  45              


Val Leu Ser Thr Asp Asp Tyr Val Thr Arg Thr Asn Ile Tyr Tyr Tyr 
    50                  55                  60                  


Ala Gly Thr Ser Arg Leu Leu Thr Val Gly His Pro Tyr Phe Pro Ile 
65                  70                  75                  80  


Pro Lys Ser Ser Asn Asn Lys Val Asp Val Pro Lys Val Ser Ala Phe 
                85                  90                  95      


Gln Tyr Arg Val Phe Arg Val Arg Leu Pro Asp Pro Asn Lys Phe Gly 
            100                 105                 110         


Leu Pro Asp Ala Arg Ile Tyr Asn Pro Asp Ala Glu Arg Leu Val Trp 
        115                 120                 125             


Ala Cys Thr Gly Val Glu Val Gly Arg Gly Gln Pro Leu Gly Val Gly 
    130                 135                 140                 


Leu Ser Gly His Pro Leu Tyr Asn Lys Leu Glu Asp Thr Glu Asn Ser 
145                 150                 155                 160 


Asn Ile Ala His Gly Pro Ile Gly Gln Asp Ser Arg Asp Asn Ile Ser 
                165                 170                 175     


Val Asp Asn Lys Gln Thr Gln Leu Cys Ile Ile Gly Cys Thr Pro Pro 
            180                 185                 190         


Met Gly Glu His Trp Gly Lys Gly Thr Pro Cys Arg Asn Pro Pro Ala 
        195                 200                 205             


Gln Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr Ser Pro Ile Gln Asp 
    210                 215                 220                 


Gly Asp Met Val Asp Thr Gly Tyr Gly Ala Met Asp Phe Thr Ala Leu 
225                 230                 235                 240 


Gln Leu Asn Lys Ser Asp Val Pro Ile Asp Ile Cys Gln Ser Thr Cys 
                245                 250                 255     


Lys Tyr Pro Asp Tyr Leu Gly Met Ala Ala Glu Pro Tyr Gly Asp Ser 
            260                 265                 270         


Met Phe Phe Tyr Leu Arg Arg Glu Gln Leu Phe Ala Arg His Phe Phe 
        275                 280                 285             


Asn Arg Ala Ser Ala Val Gly Asp Ala Ile Pro Asp Thr Phe Ile Leu 
    290                 295                 300                 


Lys Ser Asn Gly Gly Gly Arg Asp Val Gly Ser Ala Val Tyr Ser Pro 
305                 310                 315                 320 


Thr Pro Ser Gly Ser Met Val Thr Ser Glu Ala Gln Leu Phe Asn Lys 
                325                 330                 335     


Pro Tyr Trp Leu Arg Arg Ala Gln Gly His Asn Asn Gly Ile Cys Trp 
            340                 345                 350         


Ala Asn Gln Leu Phe Val Thr Val Val Asp Thr Thr Arg Ser Thr Asn 
        355                 360                 365             


Met Cys Leu Cys Val Pro Ser Glu Ala Ser Pro Ala Thr Thr Tyr Asp 
    370                 375                 380                 


Ala Thr Lys Phe Lys Glu Tyr Leu Arg His Gly Glu Glu Tyr Asp Leu 
385                 390                 395                 400 


Gln Phe Ile Phe Gln Leu Cys Lys Val Thr Leu Thr Pro Asp Ile Met 
                405                 410                 415     


Ala Tyr Leu His Thr Met Asn Ser Ser Leu Leu Glu Asp Trp Asn Phe 
            420                 425                 430         


Gly Leu Thr Leu Pro Pro Ser Thr Ser Leu Glu Asp Thr Tyr Arg Phe 
        435                 440                 445             


Leu Ser Ser Ser Ala Ile Thr Cys Gln Lys Asp Thr Pro Pro Thr Glu 
    450                 455                 460                 


Lys Gln Asp Pro Tyr Ala Lys Leu Asn Phe Trp Asp Val Asp Leu Lys 
465                 470                 475                 480 


Asp Arg Phe Ser Leu Asp Leu Ser Gln Phe Pro Leu Gly Arg Lys Phe 
                485                 490                 495     


Leu Leu Gln Leu Gly Val Arg Ser Arg Ser Ala Val Ser Val Arg Lys 
            500                 505                 510         


Arg Pro Ala Thr Ser Ala Thr Gly Ser Thr Ala Ala Lys Arg Lys Arg 
        515                 520                 525             


Thr Lys Lys 
    530     


<210>  18
<211>  568
<212>  PRT
<213>  Human papillomavirus type 18


<220>
<221>  L1 protein HPV 18
<222>  (1)..(568)

<400>  18

Met Cys Leu Tyr Thr Arg Val Leu Ile Leu His Tyr His Leu Leu Pro 
1               5                   10                  15      


Leu Tyr Gly Pro Leu Tyr His Pro Arg Pro Leu Pro Leu His Ser Ile 
            20                  25                  30          


Leu Val Tyr Met Val His Ile Ile Ile Cys Gly His Tyr Ile Ile Leu 
        35                  40                  45              


Phe Leu Arg Asn Val Asn Val Phe Pro Ile Phe Leu Gln Met Ala Leu 
    50                  55                  60                  


Trp Arg Pro Ser Asp Asn Thr Val Tyr Leu Pro Pro Pro Ser Val Ala 
65                  70                  75                  80  


Arg Val Val Asn Thr Asp Asp Tyr Val Thr Pro Thr Ser Ile Phe Tyr 
                85                  90                  95      


His Ala Gly Ser Ser Arg Leu Leu Thr Val Gly Asn Pro Tyr Phe Arg 
            100                 105                 110         


Val Pro Ala Gly Gly Gly Asn Lys Gln Asp Ile Pro Lys Val Ser Ala 
        115                 120                 125             


Tyr Gln Tyr Arg Val Phe Arg Val Gln Leu Pro Asp Pro Asn Lys Phe 
    130                 135                 140                 


Gly Leu Pro Asp Thr Ser Ile Tyr Asn Pro Glu Thr Gln Arg Leu Val 
145                 150                 155                 160 


Trp Ala Cys Ala Gly Val Glu Ile Gly Arg Gly Gln Pro Leu Gly Val 
                165                 170                 175     


Gly Leu Ser Gly His Pro Phe Tyr Asn Lys Leu Asp Asp Thr Glu Ser 
            180                 185                 190         


Ser His Ala Ala Thr Ser Asn Val Ser Glu Asp Val Arg Asp Asn Val 
        195                 200                 205             


Ser Val Asp Tyr Lys Gln Thr Gln Leu Cys Ile Leu Gly Cys Ala Pro 
    210                 215                 220                 


Ala Ile Gly Glu His Trp Ala Lys Gly Thr Ala Cys Lys Ser Arg Pro 
225                 230                 235                 240 


Leu Ser Gln Gly Asp Cys Pro Pro Leu Glu Leu Lys Asn Thr Val Leu 
                245                 250                 255     


Glu Asp Gly Asp Met Val Asp Thr Gly Tyr Gly Ala Met Asp Phe Ser 
            260                 265                 270         


Thr Leu Gln Asp Thr Lys Cys Glu Val Pro Leu Asp Ile Cys Gln Ser 
        275                 280                 285             


Ile Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ser Ala Asp Pro Tyr Gly 
    290                 295                 300                 


Asp Ser Met Phe Phe Cys Leu Arg Arg Glu Gln Leu Phe Ala Arg His 
305                 310                 315                 320 


Phe Trp Asn Arg Ala Gly Thr Met Gly Asp Thr Val Pro Gln Ser Leu 
                325                 330                 335     


Tyr Ile Lys Gly Thr Gly Met Pro Ala Ser Pro Gly Ser Cys Val Tyr 
            340                 345                 350         


Ser Pro Ser Pro Ser Gly Ser Ile Val Thr Ser Asp Ser Gln Leu Phe 
        355                 360                 365             


Asn Lys Pro Tyr Trp Leu His Lys Ala Gln Gly His Asn Asn Gly Val 
    370                 375                 380                 


Cys Trp His Asn Gln Leu Phe Val Thr Val Val Asp Thr Thr Pro Ser 
385                 390                 395                 400 


Thr Asn Leu Thr Ile Cys Ala Ser Thr Gln Ser Pro Val Pro Gly Gln 
                405                 410                 415     


Tyr Asp Ala Thr Lys Phe Lys Gln Tyr Ser Arg His Val Glu Glu Tyr 
            420                 425                 430         


Asp Leu Gln Phe Ile Phe Gln Leu Cys Thr Ile Thr Leu Thr Ala Asp 
        435                 440                 445             


Val Met Ser Tyr Ile His Ser Met Asn Ser Ser Ile Leu Glu Asp Trp 
    450                 455                 460                 


Asn Phe Gly Val Pro Pro Pro Pro Thr Thr Ser Leu Val Asp Thr Tyr 
465                 470                 475                 480 


Arg Phe Val Gln Ser Val Ala Ile Thr Cys Gln Lys Asp Ala Ala Pro 
                485                 490                 495     


Ala Glu Asn Lys Asp Pro Tyr Asp Lys Leu Lys Phe Trp Asn Val Asp 
            500                 505                 510         


Leu Lys Glu Lys Phe Ser Leu Asp Leu Asp Gln Tyr Pro Leu Gly Arg 
        515                 520                 525             


Lys Phe Leu Val Gln Ala Gly Leu Arg Arg Lys Pro Thr Ile Gly Pro 
    530                 535                 540                 


Arg Lys Arg Ser Ala Pro Ser Ala Thr Thr Ser Ser Lys Pro Ala Lys 
545                 550                 555                 560 


Arg Val Arg Val Arg Ala Arg Lys 
                565             


<210>  19
<211>  501
<212>  PRT
<213>  Human papillomavirus type 11


<220>
<221>  L1 protein HPV 11
<222>  (1)..(501)

<400>  19

Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val Pro Pro Pro Asn Pro 
1               5                   10                  15      


Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val Lys Arg Thr Asn Ile 
            20                  25                  30          


Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala Val Gly His Pro Tyr 
        35                  40                  45              


Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val Pro Lys Val Ser Gly 
    50                  55                  60                  


Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro Asn Lys Phe 
65                  70                  75                  80  


Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln Arg Leu Val 
                85                  90                  95      


Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro Leu Gly Val 
            100                 105                 110         


Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr Asp Asp Val Glu Asn 
        115                 120                 125             


Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp Asn Arg Val Asn Val 
    130                 135                 140                 


Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly Cys Ala Pro 
145                 150                 155                 160 


Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln Cys Ser Asn Thr Ser 
                165                 170                 175     


Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr Ser Val Ile 
            180                 185                 190         


Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met Asn Phe Ala 
        195                 200                 205             


Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu Asp Ile Cys Gly Thr 
    210                 215                 220                 


Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp Pro Tyr Gly 
225                 230                 235                 240 


Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln Met Phe Ala Arg His 
                245                 250                 255     


Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro Val Pro Asp Asp Leu 
            260                 265                 270         


Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val Ala Ser Ser Ile Tyr 
        275                 280                 285             


Val His Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala Gln Leu Phe 
    290                 295                 300                 


Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn Asn Gly Ile 
305                 310                 315                 320 


Cys Trp Gly Asn His Leu Phe Val Thr Val Val Asp Thr Thr Arg Ser 
                325                 330                 335     


Thr Asn Met Thr Leu Cys Ala Ser Val Ser Lys Ser Ala Thr Tyr Thr 
            340                 345                 350         


Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu Phe Asp Leu 
        355                 360                 365             


Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala Glu Val Met 
    370                 375                 380                 


Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp Trp Asn Phe 
385                 390                 395                 400 


Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr Tyr Arg Tyr 
                405                 410                 415     


Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro Glu Lys Glu 
            420                 425                 430         


Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val Asn Leu Lys 
        435                 440                 445             


Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly Arg Lys Phe 
    450                 455                 460                 


Leu Leu Gln Ser Gly Tyr Arg Gly Arg Thr Ser Ala Arg Thr Gly Ile 
465                 470                 475                 480 


Lys Arg Pro Ala Val Ser Lys Pro Ser Thr Ala Pro Lys Arg Lys Arg 
                485                 490                 495     


Thr Lys Thr Lys Lys 
            500     


