                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Siegel, Donald L.
       Milone, Michael C.
       Kacir, Stephen
       Rader, Christoph
 
<120>  Glycosyl-phosphatidylinositol (GPI)-linked GDNF family 
       alpha-receptor 4 (GFRalpha4)-Specific Antibody And Uses Thereof

<130>  046483-7046WO1(01001)

<150>  62/037,434
<151>  2014-08-14

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1

Asn Arg Cys Val Asp Ala Ala Glu Ala Cys Thr Ala Asp Ala Arg Cys 
1               5                   10                  15      


Gln Arg Leu Arg Ser Glu Tyr Val Ala Gln Cys Leu Gly Arg Ala Ala 
            20                  25                  30          


Gln Gly Gly Cys Pro Arg Ala Arg Cys Arg Arg Ala Leu Arg Arg Phe 
        35                  40                  45              


Phe Ala Arg Gly Pro Pro Ala Leu Thr His Ala Leu Leu Phe Cys Pro 
    50                  55                  60                  


Cys Ala Gly Pro Ala Cys Ala Glu Arg Arg Arg Gln Thr Phe Val Pro 
65                  70                  75                  80  


Ser Cys Ala Phe Ser Gly Pro Gly Pro Ala Pro Pro Ser Cys Leu Glu 
                85                  90                  95      


Pro Leu Asn Phe Cys Glu Arg Ser Arg Val Cys Arg Pro Arg Leu Leu 
            100                 105                 110         


Ala Phe Gln Val Ser Cys Thr Pro Ala Pro Ser Ala Pro Asp Gly Cys 
        115                 120                 125             


Leu Leu Asp Gln Gly Ala Arg Cys Leu Arg Ala Tyr Ala Gly Leu Val 
    130                 135                 140                 


Gly Thr Ala Val Thr Pro Asn Tyr Val Asp Asn Val Ser Ala Arg Val 
145                 150                 155                 160 


Ala Pro Trp Cys Asp Cys Gly Ala Ser Gly Asn Arg Arg Glu Asp Cys 
                165                 170                 175     


Glu Ala Phe Arg Gly Leu Phe Thr Arg Asn Arg Cys Leu Asp Gly Ala 
            180                 185                 190         


Ile Gln Ala Phe Ala Ser Gly Trp Pro Pro Val Leu Leu Asp Gln Leu 
        195                 200                 205             


Asn Pro Gln Gly Asp Pro Glu His Ser Leu Leu Gln Val Ser Ile Glu 
    210                 215                 220                 


Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His His 
    450                 455                 460                 


His 
465 


<210>  2
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Arg Cys Val Asp Ala Ala Glu Ala Cys Thr Ala Asp Ala Arg Cys 
1               5                   10                  15      


Gln Arg Leu Arg Ser Glu Tyr Val Ala Gln Cys Leu Gly Arg Ala Ala 
            20                  25                  30          


Gln Gly Gly Cys Pro Arg Ala Arg Cys Arg Arg Ala Leu Arg Arg Phe 
        35                  40                  45              


Phe Ala Arg Gly Pro Pro Ala Leu Thr His Ala Leu Leu Phe Cys Pro 
    50                  55                  60                  


Cys Ala Gly Pro Ala Cys Ala Glu Arg Arg Arg Gln Thr Phe Val Pro 
65                  70                  75                  80  


Ser Cys Ala Phe Ser Gly Pro Gly Pro Ala Pro Pro Ser Cys Leu Glu 
                85                  90                  95      


Pro Leu Asn Phe Cys Glu Arg Ser Arg Val Cys Arg Cys Ala Arg Ala 
            100                 105                 110         


Ala Ala Gly Pro Trp Arg Gly Trp Gly Arg Gly Leu Ser Pro Ala His 
        115                 120                 125             


Arg Pro Pro Ala Ala Gln Ala Ser Pro Pro Gly Leu Ser Gly Leu Val 
    130                 135                 140                 


His Pro Ser Ala Gln Arg Pro Arg Arg Leu Pro Ala Gly Pro Gly Arg 
145                 150                 155                 160 


Pro Leu Pro Ala Arg Leu Arg Gly Pro Arg Gly Val Pro Ala Gly Thr 
                165                 170                 175     


Ala Val Thr Pro Asn Tyr Val Asp Asn Val Ser Ala Arg Val Ala Pro 
            180                 185                 190         


Trp Cys Asp Cys Gly Ala Ser Gly Asn Arg Arg Glu Asp Cys Glu Ala 
        195                 200                 205             


Phe Arg Gly Leu Phe Thr Arg Asn Arg Cys Leu Asp Gly Ala Ile Gln 
    210                 215                 220                 


Ala Phe Ala Ser Gly Trp Pro Pro Val Leu Leu Asp Gln Leu Asn Pro 
225                 230                 235                 240 


Gln Gly Asp Pro Glu His Ser Leu Leu Gln Val Gly Gly Gly Glu Asn 
                245                 250                 255     


Leu Tyr Phe Gln Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys 
    


<210>  3
<211>  354
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  3
gagcagctga aggagtccgg gggaggtctc ttcaagccaa cggataccct gacactcacc       60

tgcacagtct ctggattctc cctcagttac tatggagtga actgggtccg ccaggctcca      120

gggaacgggc tggaatggat cggaaccatt ggtggtagtg gtgacacata ctacgcgagc      180

tgggcgaaga gccgatccac catcatcaga aacaccaacg agaacacggt gactctgaaa      240

atgaccagtc tgacagccgc ggacacggcc acctatttct gtgtgagata tgctaatatt      300

ggttatgagt actttaacgt ctggggtcca ggcaccctgg tcaccgtctc ttca            354


<210>  4
<211>  118
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Tyr Tyr Gly 
            20                  25                  30          


Val Asn Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Ile Gly Gly Ser Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Ile Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Val Arg 
                85                  90                  95      


Tyr Ala Asn Ile Gly Tyr Glu Tyr Phe Asn Val Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  5
<211>  24
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  5
ggattctccc tcagttacta tgga                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Gly Phe Ser Leu Ser Tyr Tyr Gly 
1               5               


<210>  7
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  7
attggtggta gtggtgacac a                                                 21


<210>  8
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Ile Gly Gly Ser Gly Asp Thr 
1               5           


<210>  9
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  9
gtgagatatg ctaatattgg ttatgagtac tttaacgtc                              39


<210>  10
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  10

Val Arg Tyr Ala Asn Ile Gly Tyr Glu Tyr Phe Asn Val 
1               5                   10              


<210>  11
<211>  333
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  11
cagtttgtgc tgactcagtc gccctctgca tctgctgccc tgggagcctc ggccaagctc       60

acctgcaccc tgagcagtgc ccacaagacc tacaccattg actggtatca gcagcagaaa      120

gggaaggccc ctcgctacct gatacaagtt aagagtgatg gaacctacac caaggcgacc      180

ggggtccctg atcgcttctc gggctccagc tctggggctg accgctacct gatcatcccc      240

agcgtccagg ctgatgacga agccgactac tattgtggta cagattatac cggtgggtat      300

gtgttcggcg gggggaccca gctgaccgtc aca                                   333


<210>  12
<211>  111
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Lys Gly Lys Ala Pro Arg Tyr Leu Ile 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Thr Tyr Thr Lys Ala Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Asp Tyr 
                85                  90                  95      


Thr Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr 
            100                 105                 110     


<210>  13
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  13
agtgcccaca agacctacac c                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  14

Ser Ala His Lys Thr Tyr Thr 
1               5           


<210>  15
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  15
gttaagagtg atggaaccta c                                                 21


<210>  16
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  16

Val Lys Ser Asp Gly Thr Tyr 
1               5           


<210>  17
<211>  27
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  17
ggtacagatt ataccggtgg gtatgtg                                           27


<210>  18
<211>  9
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  18

Gly Thr Asp Tyr Thr Gly Gly Tyr Val 
1               5                   


<210>  19
<211>  369
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  19
cagtcagtga aggagtccga gggaggtctc ttcaagccaa cggataccct gacactcacc       60

tgcacggtct ctggattctc cctcagtaga catgcactga cctgggtccg ccaggctcca      120

gggaacgggc tggaatggat cggagccatt gataacgctg gtaccacata ctacgcgagc      180

tgggcgaaaa gccgctccac catcaccaga aacaccgacc tgcacacggt gactctgaaa      240

atgaccagtc tgacagcctc ggacacggct acctatttct gtgcgagagt cttttatgat      300

attaatagtg gttattatct ggacggcatg gacctctggg gcccagggac cctcgtcacc      360

gtctcttca                                                              369


<210>  20
<211>  123
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  20

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg His Ala 
            20                  25                  30          


Leu Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asp Leu His Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  21
<211>  24
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  21
ggattctccc tcagtagaca tgca                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  22

Gly Phe Ser Leu Ser Arg His Ala 
1               5               


<210>  23
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  23
attgataacg ctggtaccac a                                                 21


<210>  24
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  24

Ile Asp Asn Ala Gly Thr Thr 
1               5           


<210>  25
<211>  54
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  25
gcgagagtct tttatgatat taatagtggt tattatctgg acggcatgga cctc             54


<210>  26
<211>  18
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met 
1               5                   10                  15      


Asp Leu 
        


<210>  27
<211>  333
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  27
cagtttgtgc tgactcagtc gccctctgtg tctgccgccc tgggagcctc tgccaagctc       60

acctgcaccc tgagcagtgc ccacaagacc tacaccattg actggtatca gcagcagcaa      120

ggggaggccc ctcggtacct gatgcaagtt aagagtgatg gaagctacac caaggggacc      180

ggggtccctg atcgcttctc gggctccagc tctggggctg accgctactt gatcatcccc      240

agcgtccagg ctgatgacga agccggctac gtttgtggtg cagatgataa cggtgggtat      300

gtgttcggcg gagggaccca gctgaccgtc aca                                   333


<210>  28
<211>  111
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Gly Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr 
            100                 105                 110     


<210>  29
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  29
agtgcccaca agacctacac c                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  30

Ser Ala His Lys Thr Tyr Thr 
1               5           


<210>  31
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  31
gttaagagtg atggaagcta c                                                 21


<210>  32
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  32

Val Lys Ser Asp Gly Ser Tyr 
1               5           


<210>  33
<211>  27
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  33
ggtgcagatg ataacggtgg gtatgtg                                           27


<210>  34
<211>  9
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  34

Gly Ala Asp Asp Asn Gly Gly Tyr Val 
1               5                   


<210>  35
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35
ggatccgagc agctgaagga gtccggggga ggtctcttca agccaacgga taccctgaca       60

ctcacctgca cagtctctgg attctccctc agttactatg gagtgaactg ggtccgccag      120

gctccaggga acgggctgga atggatcgga accattggtg gtagtggtga cacatactac      180

gcgagctggg cgaagagccg atccaccatc atcagaaaca ccaacgagaa cacggtgact      240

ctgaaaatga ccagtctgac agccgcggac acggccacct atttctgtgt gagatatgct      300

aatattggtt atgagtactt taacgtctgg ggtccaggca ccctggtcac cgtctcttca      360

ggtggaggcg gttcaggcgg cggtggctct agcggtggtg gatcgcagtt tgtgctgact      420

cagtcgccct ctgcatctgc tgccctggga gcctcggcca agctcacctg caccctgagc      480

agtgcccaca agacctacac cattgactgg tatcagcagc agaaagggaa ggcccctcgc      540

tacctgatac aagttaagag tgatggaacc tacaccaagg cgaccggggt ccctgatcgc      600

ttctcgggct ccagctctgg ggctgaccgc tacctgatca tccccagcgt ccaggctgat      660

gacgaagccg actactattg tggtacagat tataccggtg ggtatgtgtt cggcgggggg      720

acccagctga ccgtcacagc tagc                                             744


<210>  36
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Gly Ser Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr 
1               5                   10                  15      


Asp Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Tyr 
            20                  25                  30          


Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Thr Ile Gly Gly Ser Gly Asp Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Ser Arg Ser Thr Ile Ile Arg Asn Thr Asn Glu Asn Thr Val Thr 
65                  70                  75                  80  


Leu Lys Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Tyr Ala Asn Ile Gly Tyr Glu Tyr Phe Asn Val Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ser Gly Gly Gly Ser Gln Phe Val Leu Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ala Ser Ala Ala Leu Gly Ala Ser Ala Lys Leu Thr Cys Thr Leu Ser 
145                 150                 155                 160 


Ser Ala His Lys Thr Tyr Thr Ile Asp Trp Tyr Gln Gln Gln Lys Gly 
                165                 170                 175     


Lys Ala Pro Arg Tyr Leu Ile Gln Val Lys Ser Asp Gly Thr Tyr Thr 
            180                 185                 190         


Lys Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala 
        195                 200                 205             


Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Gly Thr Asp Tyr Thr Gly Gly Tyr Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Gln Leu Thr Val Thr Ala Ser 
                245             


<210>  37
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37
ggatcccagt cagtgaagga gtccgaggga ggtctcttca agccaacgga taccctgaca       60

ctcacctgca cggtctctgg attctccctc agtagacatg cactgacctg ggtccgccag      120

gctccaggga acgggctgga atggatcgga gccattgata acgctggtac cacatactac      180

gcgagctggg cgaaaagccg ctccaccatc accagaaaca ccgacctgca cacggtgact      240

ctgaaaatga ccagtctgac agcctcggac acggctacct atttctgtgc gagagtcttt      300

tatgatatta atagtggtta ttatctggac ggcatggacc tctggggccc agggaccctc      360

gtcaccgtct cttcaggtgg aggcggttca ggcggcggtg gctctagcgg tggtggatcg      420

cagtttgtgc tgactcagtc gccctctgtg tctgccgccc tgggagcctc tgccaagctc      480

acctgcaccc tgagcagtgc ccacaagacc tacaccattg actggtatca gcagcagcaa      540

ggggaggccc ctcggtacct gatgcaagtt aagagtgatg gaagctacac caaggggacc      600

ggggtccctg atcgcttctc gggctccagc tctggggctg accgctactt gatcatcccc      660

agcgtccagg ctgatgacga agccggctac gtttgtggtg cagatgataa cggtgggtat      720

gtgttcggcg gagggaccca gctgaccgtc acagctagc                             759


<210>  38
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Gly Ser Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr 
1               5                   10                  15      


Asp Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg 
            20                  25                  30          


His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Ser Arg Ser Thr Ile Thr Arg Asn Thr Asp Leu His Thr Val Thr 
65                  70                  75                  80  


Leu Lys Met Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met 
            100                 105                 110         


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Phe Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala Ser Ala Lys Leu 
145                 150                 155                 160 


Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp Tyr 
                165                 170                 175     


Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Lys Ser 
            180                 185                 190         


Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala 
    210                 215                 220                 


Asp Asp Glu Ala Gly Tyr Val Cys Gly Ala Asp Asp Asn Gly Gly Tyr 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Ala Ser 
                245                 250             


<210>  39
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39
ggatccgagc agctgaagga gtccggcgga ggcctgttta agcccaccga caccctgaca       60

ctgacctgca cagtgtccgg cttcagcctg agctactatg gcgtgaactg ggtgagacag      120

gcccctggca acggactgga gtggatcggc accattggcg gcagcggaga cacctactac      180

gccagctggg ccaagtccag gagcaccatc atcagaaaca ccaacgagaa caccgtgacc      240

ctgaagatga cctccctgac agccgccgac accgccacct acttctgcgt gaggtacgcc      300

aacatcggct acgagtactt caacgtgtgg ggccctggca ccctggtgac agtgtccagc      360

ggcggaggag gaagcggcgg cggcggctcc agcggaggcg gcagccagtt tgtgctgacc      420

cagagcccta gcgcttccgc cgccctgggc gccagcgcca agctcacctg taccctgagc      480

agcgcccaca agacctatac catcgactgg taccagcagc agaagggcaa ggcccccagg      540

tacctgatcc aggtgaagtc cgacggcacc tacaccaaag ccaccggcgt gcccgacaga      600

tttagcggca gcagctccgg cgccgacagg tatctgatca tcccttccgt gcaggccgac      660

gacgaggccg actactactg cggaaccgac tacaccggcg gatacgtgtt cggaggcggc      720

acccagctga ccgtgaccgc tagc                                             744


<210>  40
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40
ggatcccagt ccgtgaagga gagcgagggc ggcctgttca agcccaccga caccctgacc       60

ctgacctgca cagtgagcgg cttcagcctg tccagacacg ccctgacatg ggtgagacag      120

gcccctggca acggcctgga atggatcggc gccatcgaca acgccggcac cacctactac      180

gccagctggg ccaagtccag gtccaccatc accaggaaca ccgacctcca caccgtgacc      240

ctgaagatga caagcctgac cgcctccgac accgccacct acttctgcgc cagggtgttc      300

tacgacatca acagcggcta ctacctggat ggcatggacc tgtggggacc tggcacactg      360

gtgaccgtga gcagcggagg cggcggcagc ggcggcggcg gcagcagcgg cggcggaagc      420

cagttcgtgc tgacacagag ccctagcgtg agcgccgccc tgggagcctc cgctaaactg      480

acctgcaccc tgagcagcgc ccacaagacc tacaccatcg actggtacca acagcagcag      540

ggcgaggccc ccaggtatct gatgcaggtg aagtccgacg gcagctacac caaaggcacc      600

ggcgtgcctg acaggttcag cggcagctcc agcggagccg acaggtacct gatcatcccc      660

tccgtgcagg ccgacgacga ggctggctac gtgtgtggcg ccgacgacaa tggcggctac      720

gtgttcggag gcggcaccca gctgaccgtg acagctagc                             759


<210>  41
<211>  9070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatccgagc agctgaagga gtccggggga ggtctcttca agccaacgga taccctgaca     5640

ctcacctgca cagtctctgg attctccctc agttactatg gagtgaactg ggtccgccag     5700

gctccaggga acgggctgga atggatcgga accattggtg gtagtggtga cacatactac     5760

gcgagctggg cgaagagccg atccaccatc atcagaaaca ccaacgagaa cacggtgact     5820

ctgaaaatga ccagtctgac agccgcggac acggccacct atttctgtgt gagatatgct     5880

aatattggtt atgagtactt taacgtctgg ggtccaggca ccctggtcac cgtctcttca     5940

ggtggaggcg gttcaggcgg cggtggctct agcggtggtg gatcgcagtt tgtgctgact     6000

cagtcgccct ctgcatctgc tgccctggga gcctcggcca agctcacctg caccctgagc     6060

agtgcccaca agacctacac cattgactgg tatcagcagc agaaagggaa ggcccctcgc     6120

tacctgatac aagttaagag tgatggaacc tacaccaagg cgaccggggt ccctgatcgc     6180

ttctcgggct ccagctctgg ggctgaccgc tacctgatca tccccagcgt ccaggctgat     6240

gacgaagccg actactattg tggtacagat tataccggtg ggtatgtgtt cggcgggggg     6300

acccagctga ccgtcacagc tagcggtggc ggaggttctg gaggtggagg ttcctccgga     6360

atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgtc cctggtcatc     6420

accctgtact gcaagcgggg cagaaagaag ctgctgtaca tcttcaagca gcccttcatg     6480

cggcctgtgc agaccacaca ggaagaggac ggctgtagct gtagattccc cgaggaagag     6540

gaaggcggct gcgagctgag agtgaagttc agcagaagcg ccgacgcccc tgcctatcag     6600

cagggccaga accagctgta caacgagctg aacctgggca gacgggagga atacgacgtg     6660

ctggacaaga gaagaggccg ggaccctgag atgggcggca agcccagacg gaagaacccc     6720

caggaaggcc tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc     6780

ggcatgaagg gcgagcggag aagaggcaag ggccatgacg gcctgtacca gggcctgagc     6840

accgccacca aggacaccta cgacgccctg cacatgcagg ccctgcctcc aagatgagtc     6900

gacaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     6960

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc     7020

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag     7080

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc     7140

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc     7200

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg     7260

ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt tccttggctg     7320

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc     7380

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt     7440

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcctggaatt     7500

cgagctcggt acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt     7560

taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa gatctgcttt     7620

ttgcttgtac tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac     7680

tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg     7740

cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga     7800

aaatctctag cagtagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga     7860

aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa     7920

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     7980

tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc     8040

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     8100

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     8160

agctagggac gtacccaatt cgccctatag tgagtcgtat tacgcgcgct cactggccgt     8220

cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc     8280

acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca     8340

acagttgcgc agcctgaatg gcgaatggga cgcgccctgt agcggcgcat taagcgcggc     8400

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     8460

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     8520

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     8580

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     8640

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     8700

ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     8760

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgcttac     8820

aatttaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     8880

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     8940

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     9000

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     9060

gatcagttgg                                                            9070


<210>  42
<211>  9085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatcccagt cagtgaagga gtccgaggga ggtctcttca agccaacgga taccctgaca     5640

ctcacctgca cggtctctgg attctccctc agtagacatg cactgacctg ggtccgccag     5700

gctccaggga acgggctgga atggatcgga gccattgata acgctggtac cacatactac     5760

gcgagctggg cgaaaagccg ctccaccatc accagaaaca ccgacctgca cacggtgact     5820

ctgaaaatga ccagtctgac agcctcggac acggctacct atttctgtgc gagagtcttt     5880

tatgatatta atagtggtta ttatctggac ggcatggacc tctggggccc agggaccctc     5940

gtcaccgtct cttcaggtgg aggcggttca ggcggcggtg gctctagcgg tggtggatcg     6000

cagtttgtgc tgactcagtc gccctctgtg tctgccgccc tgggagcctc tgccaagctc     6060

acctgcaccc tgagcagtgc ccacaagacc tacaccattg actggtatca gcagcagcaa     6120

ggggaggccc ctcggtacct gatgcaagtt aagagtgatg gaagctacac caaggggacc     6180

ggggtccctg atcgcttctc gggctccagc tctggggctg accgctactt gatcatcccc     6240

agcgtccagg ctgatgacga agccggctac gtttgtggtg cagatgataa cggtgggtat     6300

gtgttcggcg gagggaccca gctgaccgtc acagctagcg gtggcggagg ttctggaggt     6360

ggaggttcct ccggaatcta catctgggcc cctctggccg gcacctgtgg cgtgctgctg     6420

ctgtccctgg tcatcaccct gtactgcaag cggggcagaa agaagctgct gtacatcttc     6480

aagcagccct tcatgcggcc tgtgcagacc acacaggaag aggacggctg tagctgtaga     6540

ttccccgagg aagaggaagg cggctgcgag ctgagagtga agttcagcag aagcgccgac     6600

gcccctgcct atcagcaggg ccagaaccag ctgtacaacg agctgaacct gggcagacgg     6660

gaggaatacg acgtgctgga caagagaaga ggccgggacc ctgagatggg cggcaagccc     6720

agacggaaga acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag     6780

gcctacagcg agatcggcat gaagggcgag cggagaagag gcaagggcca tgacggcctg     6840

taccagggcc tgagcaccgc caccaaggac acctacgacg ccctgcacat gcaggccctg     6900

cctccaagat gagtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt     6960

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     7020

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg     7080

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt     7140

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact     7200

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     7260

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg     7320

tcctttcctt ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc     7380

tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg     7440

cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc     7500

tccccgcctg gaattcgagc tcggtacctt taagaccaat gacttacaag gcagctgtag     7560

atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa     7620

gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg     7680

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc     7740

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct     7800

tttagtcagt gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt     7860

tataacttgc aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata     7920

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     7980

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat     8040

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     8100

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     8160

cttttttgga ggcctagcta gggacgtacc caattcgccc tatagtgagt cgtattacgc     8220

gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact     8280

taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac     8340

cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg     8400

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     8460

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     8520

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     8580

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac     8640

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     8700

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat     8760

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     8820

aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg aacccctatt     8880

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     8940

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     9000

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     9060

gtaaaagatg ctgaagatca gttgg                                           9085


<210>  43
<211>  9175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatccgagc agctgaagga gtccggggga ggtctcttca agccaacgga taccctgaca     5640

ctcacctgca cagtctctgg attctccctc agttactatg gagtgaactg ggtccgccag     5700

gctccaggga acgggctgga atggatcgga accattggtg gtagtggtga cacatactac     5760

gcgagctggg cgaagagccg atccaccatc atcagaaaca ccaacgagaa cacggtgact     5820

ctgaaaatga ccagtctgac agccgcggac acggccacct atttctgtgt gagatatgct     5880

aatattggtt atgagtactt taacgtctgg ggtccaggca ccctggtcac cgtctcttca     5940

ggtggaggcg gttcaggcgg cggtggctct agcggtggtg gatcgcagtt tgtgctgact     6000

cagtcgccct ctgcatctgc tgccctggga gcctcggcca agctcacctg caccctgagc     6060

agtgcccaca agacctacac cattgactgg tatcagcagc agaaagggaa ggcccctcgc     6120

tacctgatac aagttaagag tgatggaacc tacaccaagg cgaccggggt ccctgatcgc     6180

ttctcgggct ccagctctgg ggctgaccgc tacctgatca tccccagcgt ccaggctgat     6240

gacgaagccg actactattg tggtacagat tataccggtg ggtatgtgtt cggcgggggg     6300

acccagctga ccgtcacagc tagcaccacg acgccagcgc cgcgaccacc aacaccggcg     6360

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     6420

ggcgcagtgc acacgagggg gctggacttc gcctgtgatt ccggaatcta catctgggcc     6480

cctctggccg gcacctgtgg cgtgctgctg ctgtccctgg tcatcaccct gtactgcaag     6540

cggggcagaa agaagctgct gtacatcttc aagcagccct tcatgcggcc tgtgcagacc     6600

acacaggaag aggacggctg tagctgtaga ttccccgagg aagaggaagg cggctgcgag     6660

ctgagagtga agttcagcag aagcgccgac gcccctgcct atcagcaggg ccagaaccag     6720

ctgtacaacg agctgaacct gggcagacgg gaggaatacg acgtgctgga caagagaaga     6780

ggccgggacc ctgagatggg cggcaagccc agacggaaga acccccagga aggcctgtat     6840

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag     6900

cggagaagag gcaagggcca tgacggcctg taccagggcc tgagcaccgc caccaaggac     6960

acctacgacg ccctgcacat gcaggccctg cctccaagat gagtcgacaa tcaacctctg     7020

gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta     7080

tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt     7140

ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc     7200

aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt     7260

gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg     7320

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     7380

aattccgtgg tgttgtcggg gaagctgacg tcctttcctt ggctgctcgc ctgtgttgcc     7440

acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac     7500

cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct     7560

cagacgagtc ggatctccct ttgggccgcc tccccgcctg gaattcgagc tcggtacctt     7620

taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg     7680

gactggaagg gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt     7740

ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc     7800

ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg     7860

actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta     7920

gtagttcatg tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga     7980

gtgagaggaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     8040

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     8100

atgtatctta tcatgtctgg ctctagctat cccgccccta actccgccca gttccgccca     8160

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc     8220

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctagcta gggacgtacc     8280

caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg     8340

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     8400

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     8460

gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     8520

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     8580

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     8640

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     8700

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     8760

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     8820

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     8880

ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt aggtggcact     8940

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     9000

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     9060

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     9120

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgg          9175


<210>  44
<211>  9190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatcccagt cagtgaagga gtccgaggga ggtctcttca agccaacgga taccctgaca     5640

ctcacctgca cggtctctgg attctccctc agtagacatg cactgacctg ggtccgccag     5700

gctccaggga acgggctgga atggatcgga gccattgata acgctggtac cacatactac     5760

gcgagctggg cgaaaagccg ctccaccatc accagaaaca ccgacctgca cacggtgact     5820

ctgaaaatga ccagtctgac agcctcggac acggctacct atttctgtgc gagagtcttt     5880

tatgatatta atagtggtta ttatctggac ggcatggacc tctggggccc agggaccctc     5940

gtcaccgtct cttcaggtgg aggcggttca ggcggcggtg gctctagcgg tggtggatcg     6000

cagtttgtgc tgactcagtc gccctctgtg tctgccgccc tgggagcctc tgccaagctc     6060

acctgcaccc tgagcagtgc ccacaagacc tacaccattg actggtatca gcagcagcaa     6120

ggggaggccc ctcggtacct gatgcaagtt aagagtgatg gaagctacac caaggggacc     6180

ggggtccctg atcgcttctc gggctccagc tctggggctg accgctactt gatcatcccc     6240

agcgtccagg ctgatgacga agccggctac gtttgtggtg cagatgataa cggtgggtat     6300

gtgttcggcg gagggaccca gctgaccgtc acagctagca ccacgacgcc agcgccgcga     6360

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     6420

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgattccgga     6480

atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgtc cctggtcatc     6540

accctgtact gcaagcgggg cagaaagaag ctgctgtaca tcttcaagca gcccttcatg     6600

cggcctgtgc agaccacaca ggaagaggac ggctgtagct gtagattccc cgaggaagag     6660

gaaggcggct gcgagctgag agtgaagttc agcagaagcg ccgacgcccc tgcctatcag     6720

cagggccaga accagctgta caacgagctg aacctgggca gacgggagga atacgacgtg     6780

ctggacaaga gaagaggccg ggaccctgag atgggcggca agcccagacg gaagaacccc     6840

caggaaggcc tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc     6900

ggcatgaagg gcgagcggag aagaggcaag ggccatgacg gcctgtacca gggcctgagc     6960

accgccacca aggacaccta cgacgccctg cacatgcagg ccctgcctcc aagatgagtc     7020

gacaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     7080

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc     7140

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag     7200

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc     7260

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc     7320

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg     7380

ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt tccttggctg     7440

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc     7500

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt     7560

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcctggaatt     7620

cgagctcggt acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt     7680

taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa gatctgcttt     7740

ttgcttgtac tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac     7800

tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg     7860

cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga     7920

aaatctctag cagtagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga     7980

aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa     8040

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     8100

tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc     8160

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     8220

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     8280

agctagggac gtacccaatt cgccctatag tgagtcgtat tacgcgcgct cactggccgt     8340

cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc     8400

acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca     8460

acagttgcgc agcctgaatg gcgaatggga cgcgccctgt agcggcgcat taagcgcggc     8520

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     8580

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     8640

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     8700

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     8760

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     8820

ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     8880

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgcttac     8940

aatttaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     9000

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     9060

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     9120

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     9180

gatcagttgg                                                            9190


