                         SEQUENCE LISTING

<110>  THE CHILDREN'S HOSPITAL OF PHILADELPHIA
       SABATINO, Denise
 
<120>  AN IMPROVED EXPRESSION CASSETTE FOR PACKAGING AND EXPRESSION OF 
       VARIANT FACTOR VIII FOR THE TREATMENT OF HEMOSTASIS DISORDERS

<130>  074659-0440902

<140>  PCT/US15/45142
<141>  2015-08-13

<150>  62/036,936
<151>  2014-08-13

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  4374
<212>  DNA
<213>  Adeno-associated virus

<400>  1
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagagg caccagcgcg agatcacccg cactaccctg     2340

cagagtgatc aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag     2400

gacttcgata tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc     2460

cggcattact ttattgctgc agtggagcgc ctgtgggatt atggcatgtc ctctagtcct     2520

cacgtgctgc gaaatcgggc ccagtcaggg agcgtcccac agttcaagaa agtggtcttc     2580

caggagttta cagacggatc ctttactcag ccactgtacc ggggcgaact gaacgagcac     2640

ctggggctgc tgggacccta tatcagagct gaagtggagg ataacattat ggtcaccttc     2700

agaaatcagg catctaggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac     2760

cagaggcagg gagcagaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac     2820

ttttggaagg tgcagcacca tatggcccca acaaaagacg aattcgattg caaggcatgg     2880

gcctattttt ctgacgtgga tctggagaag gacgtccaca gtggcctgat cgggccactg     2940

ctggtgtgtc atactaacac cctgaatccc gcacacggca ggcaggtcac tgtccaggaa     3000

ttcgccctgt tctttaccat ctttgatgag acaaaaagct ggtacttcac cgaaaacatg     3060

gagcgaaatt gccgggctcc atgtaatatt cagatggaag accccacatt caaggagaac     3120

taccgctttc atgccatcaa tgggtatatt atggatactc tgcccggact ggtcatggct     3180

caggaccaga gaatcaggtg gtacctgctg agcatggggt ccaacgagaa tatccactca     3240

attcatttca gcggacacgt gtttactgtc cggaagaaag aagagtataa aatggccctg     3300

tacaacctgt atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggcagggatc     3360

tggagagtgg aatgcctgat tggggagcac ctgcatgccg gaatgtctac cctgtttctg     3420

gtgtacagta ataagtgtca gacacccctg gggatggctt ccggacatat ccgggatttc     3480

cagattaccg catctggaca gtacggccag tgggccccta agctggctag actgcactat     3540

tccgggtcta tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg     3600

ctggcaccaa tgatcattca tggcatcaaa actcaggggg ccaggcagaa gttctcctct     3660

ctgtacatct cacagtttat catcatgtac agcctggatg gcaagaaatg gcagacatac     3720

cgcggcaata gcacagggac tctgatggtg ttctttggca acgtggacag ttcagggatc     3780

aagcacaaca ttttcaatcc ccctatcatt gctagataca tcaggctgca cccaacccat     3840

tattctattc gaagtacact gcggatggaa ctgatggggt gcgatctgaa cagttgttca     3900

atgcccctgg gaatggagtc caaggcaatc tctgacgccc agattaccgc tagctcctac     3960

ttcactaata tgtttgctac ctggagcccc tccaaagcac gactgcatct gcagggacga     4020

agcaacgcat ggcgaccaca ggtgaacaat cccaaggagt ggctgcaggt cgattttcag     4080

aaaactatga aggtgaccgg agtcacaact cagggcgtga aaagtctgct gacctcaatg     4140

tacgtcaagg agttcctgat ctctagttca caggacggcc accagtggac actgttcttt     4200

cagaacggaa aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac     4260

tctctggacc cacccctgct gactcgctac ctgcgaatcc acccacagtc ctgggtgcat     4320

cagattgcac tgagaatgga agtcctgggc tgcgaggccc aggacctgta ttga           4374


<210>  2
<211>  4374
<212>  DNA
<213>  Adeno-associated virus

<400>  2
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagcac caccagcgcg agatcacccg cactaccctg     2340

cagagtgatc aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag     2400

gacttcgata tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc     2460

cggcattact ttattgctgc agtggagcgc ctgtgggatt atggcatgtc ctctagtcct     2520

cacgtgctgc gaaatcgggc ccagtcaggg agcgtcccac agttcaagaa agtggtcttc     2580

caggagttta cagacggatc ctttactcag ccactgtacc ggggcgaact gaacgagcac     2640

ctggggctgc tgggacccta tatcagagct gaagtggagg ataacattat ggtcaccttc     2700

agaaatcagg catctaggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac     2760

cagaggcagg gagcagaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac     2820

ttttggaagg tgcagcacca tatggcccca acaaaagacg aattcgattg caaggcatgg     2880

gcctattttt ctgacgtgga tctggagaag gacgtccaca gtggcctgat cgggccactg     2940

ctggtgtgtc atactaacac cctgaatccc gcacacggca ggcaggtcac tgtccaggaa     3000

ttcgccctgt tctttaccat ctttgatgag acaaaaagct ggtacttcac cgaaaacatg     3060

gagcgaaatt gccgggctcc atgtaatatt cagatggaag accccacatt caaggagaac     3120

taccgctttc atgccatcaa tgggtatatt atggatactc tgcccggact ggtcatggct     3180

caggaccaga gaatcaggtg gtacctgctg agcatggggt ccaacgagaa tatccactca     3240

attcatttca gcggacacgt gtttactgtc cggaagaaag aagagtataa aatggccctg     3300

tacaacctgt atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggcagggatc     3360

tggagagtgg aatgcctgat tggggagcac ctgcatgccg gaatgtctac cctgtttctg     3420

gtgtacagta ataagtgtca gacacccctg gggatggctt ccggacatat ccgggatttc     3480

cagattaccg catctggaca gtacggccag tgggccccta agctggctag actgcactat     3540

tccgggtcta tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg     3600

ctggcaccaa tgatcattca tggcatcaaa actcaggggg ccaggcagaa gttctcctct     3660

ctgtacatct cacagtttat catcatgtac agcctggatg gcaagaaatg gcagacatac     3720

cgcggcaata gcacagggac tctgatggtg ttctttggca acgtggacag ttcagggatc     3780

aagcacaaca ttttcaatcc ccctatcatt gctagataca tcaggctgca cccaacccat     3840

tattctattc gaagtacact gcggatggaa ctgatggggt gcgatctgaa cagttgttca     3900

atgcccctgg gaatggagtc caaggcaatc tctgacgccc agattaccgc tagctcctac     3960

ttcactaata tgtttgctac ctggagcccc tccaaagcac gactgcatct gcagggacga     4020

agcaacgcat ggcgaccaca ggtgaacaat cccaaggagt ggctgcaggt cgattttcag     4080

aaaactatga aggtgaccgg agtcacaact cagggcgtga aaagtctgct gacctcaatg     4140

tacgtcaagg agttcctgat ctctagttca caggacggcc accagtggac actgttcttt     4200

cagaacggaa aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac     4260

tctctggacc cacccctgct gactcgctac ctgcgaatcc acccacagtc ctgggtgcat     4320

cagattgcac tgagaatgga agtcctgggc tgcgaggccc aggacctgta ttga           4374


<210>  3
<211>  4362
<212>  DNA
<213>  Adeno-associated virus

<400>  3
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaaggag atcacccgca ctaccctgca gagtgatcag     2340

gaagagatcg actacgacga tacaatttct gtggaaatga agaaagagga cttcgatatc     2400

tatgacgaag atgagaacca gagtcctcga tcattccaga agaaaacccg gcattacttt     2460

attgctgcag tggagcgcct gtgggattat ggcatgtcct ctagtcctca cgtgctgcga     2520

aatcgggccc agtcagggag cgtcccacag ttcaagaaag tggtcttcca ggagtttaca     2580

gacggatcct ttactcagcc actgtaccgg ggcgaactga acgagcacct ggggctgctg     2640

ggaccctata tcagagctga agtggaggat aacattatgg tcaccttcag aaatcaggca     2700

tctaggcctt acagttttta ttcaagcctg atctcttacg aagaggacca gaggcaggga     2760

gcagaaccac gaaaaaactt cgtgaagcct aatgagacca aaacatactt ttggaaggtg     2820

cagcaccata tggccccaac aaaagacgaa ttcgattgca aggcatgggc ctatttttct     2880

gacgtggatc tggagaagga cgtccacagt ggcctgatcg ggccactgct ggtgtgtcat     2940

actaacaccc tgaatcccgc acacggcagg caggtcactg tccaggaatt cgccctgttc     3000

tttaccatct ttgatgagac aaaaagctgg tacttcaccg aaaacatgga gcgaaattgc     3060

cgggctccat gtaatattca gatggaagac cccacattca aggagaacta ccgctttcat     3120

gccatcaatg ggtatattat ggatactctg cccggactgg tcatggctca ggaccagaga     3180

atcaggtggt acctgctgag catggggtcc aacgagaata tccactcaat tcatttcagc     3240

ggacacgtgt ttactgtccg gaagaaagaa gagtataaaa tggccctgta caacctgtat     3300

cccggcgtgt tcgaaaccgt cgagatgctg cctagcaagg cagggatctg gagagtggaa     3360

tgcctgattg gggagcacct gcatgccgga atgtctaccc tgtttctggt gtacagtaat     3420

aagtgtcaga cacccctggg gatggcttcc ggacatatcc gggatttcca gattaccgca     3480

tctggacagt acggccagtg ggcccctaag ctggctagac tgcactattc cgggtctatc     3540

aacgcttggt ccacaaaaga gcctttctct tggattaagg tggacctgct ggcaccaatg     3600

atcattcatg gcatcaaaac tcagggggcc aggcagaagt tctcctctct gtacatctca     3660

cagtttatca tcatgtacag cctggatggc aagaaatggc agacataccg cggcaatagc     3720

acagggactc tgatggtgtt ctttggcaac gtggacagtt cagggatcaa gcacaacatt     3780

ttcaatcccc ctatcattgc tagatacatc aggctgcacc caacccatta ttctattcga     3840

agtacactgc ggatggaact gatggggtgc gatctgaaca gttgttcaat gcccctggga     3900

atggagtcca aggcaatctc tgacgcccag attaccgcta gctcctactt cactaatatg     3960

tttgctacct ggagcccctc caaagcacga ctgcatctgc agggacgaag caacgcatgg     4020

cgaccacagg tgaacaatcc caaggagtgg ctgcaggtcg attttcagaa aactatgaag     4080

gtgaccggag tcacaactca gggcgtgaaa agtctgctga cctcaatgta cgtcaaggag     4140

ttcctgatct ctagttcaca ggacggccac cagtggacac tgttctttca gaacggaaag     4200

gtgaaagtct tccagggcaa tcaggattcc tttacacctg tggtcaactc tctggaccca     4260

cccctgctga ctcgctacct gcgaatccac ccacagtcct gggtgcatca gattgcactg     4320

agaatggaag tcctgggctg cgaggcccag gacctgtatt ga                        4362


<210>  4
<211>  4371
<212>  DNA
<213>  Adeno-associated virus

<400>  4
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagcac cagcgcgaga tcacccgcac taccctgcag     2340

agtgatcagg aagagatcga ctacgacgat acaatttctg tggaaatgaa gaaagaggac     2400

ttcgatatct atgacgaaga tgagaaccag agtcctcgat cattccagaa gaaaacccgg     2460

cattacttta ttgctgcagt ggagcgcctg tgggattatg gcatgtcctc tagtcctcac     2520

gtgctgcgaa atcgggccca gtcagggagc gtcccacagt tcaagaaagt ggtcttccag     2580

gagtttacag acggatcctt tactcagcca ctgtaccggg gcgaactgaa cgagcacctg     2640

gggctgctgg gaccctatat cagagctgaa gtggaggata acattatggt caccttcaga     2700

aatcaggcat ctaggcctta cagtttttat tcaagcctga tctcttacga agaggaccag     2760

aggcagggag cagaaccacg aaaaaacttc gtgaagccta atgagaccaa aacatacttt     2820

tggaaggtgc agcaccatat ggccccaaca aaagacgaat tcgattgcaa ggcatgggcc     2880

tatttttctg acgtggatct ggagaaggac gtccacagtg gcctgatcgg gccactgctg     2940

gtgtgtcata ctaacaccct gaatcccgca cacggcaggc aggtcactgt ccaggaattc     3000

gccctgttct ttaccatctt tgatgagaca aaaagctggt acttcaccga aaacatggag     3060

cgaaattgcc gggctccatg taatattcag atggaagacc ccacattcaa ggagaactac     3120

cgctttcatg ccatcaatgg gtatattatg gatactctgc ccggactggt catggctcag     3180

gaccagagaa tcaggtggta cctgctgagc atggggtcca acgagaatat ccactcaatt     3240

catttcagcg gacacgtgtt tactgtccgg aagaaagaag agtataaaat ggccctgtac     3300

aacctgtatc ccggcgtgtt cgaaaccgtc gagatgctgc ctagcaaggc agggatctgg     3360

agagtggaat gcctgattgg ggagcacctg catgccggaa tgtctaccct gtttctggtg     3420

tacagtaata agtgtcagac acccctgggg atggcttccg gacatatccg ggatttccag     3480

attaccgcat ctggacagta cggccagtgg gcccctaagc tggctagact gcactattcc     3540

gggtctatca acgcttggtc cacaaaagag cctttctctt ggattaaggt ggacctgctg     3600

gcaccaatga tcattcatgg catcaaaact cagggggcca ggcagaagtt ctcctctctg     3660

tacatctcac agtttatcat catgtacagc ctggatggca agaaatggca gacataccgc     3720

ggcaatagca cagggactct gatggtgttc tttggcaacg tggacagttc agggatcaag     3780

cacaacattt tcaatccccc tatcattgct agatacatca ggctgcaccc aacccattat     3840

tctattcgaa gtacactgcg gatggaactg atggggtgcg atctgaacag ttgttcaatg     3900

cccctgggaa tggagtccaa ggcaatctct gacgcccaga ttaccgctag ctcctacttc     3960

actaatatgt ttgctacctg gagcccctcc aaagcacgac tgcatctgca gggacgaagc     4020

aacgcatggc gaccacaggt gaacaatccc aaggagtggc tgcaggtcga ttttcagaaa     4080

actatgaagg tgaccggagt cacaactcag ggcgtgaaaa gtctgctgac ctcaatgtac     4140

gtcaaggagt tcctgatctc tagttcacag gacggccacc agtggacact gttctttcag     4200

aacggaaagg tgaaagtctt ccagggcaat caggattcct ttacacctgt ggtcaactct     4260

ctggacccac ccctgctgac tcgctacctg cgaatccacc cacagtcctg ggtgcatcag     4320

attgcactga gaatggaagt cctgggctgc gaggcccagg acctgtattg a              4371


<210>  5
<211>  4368
<212>  DNA
<213>  Adeno-associated virus

<400>  5
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagcag cgcgagatca cccgcactac cctgcagagt     2340

gatcaggaag agatcgacta cgacgataca atttctgtgg aaatgaagaa agaggacttc     2400

gatatctatg acgaagatga gaaccagagt cctcgatcat tccagaagaa aacccggcat     2460

tactttattg ctgcagtgga gcgcctgtgg gattatggca tgtcctctag tcctcacgtg     2520

ctgcgaaatc gggcccagtc agggagcgtc ccacagttca agaaagtggt cttccaggag     2580

tttacagacg gatcctttac tcagccactg taccggggcg aactgaacga gcacctgggg     2640

ctgctgggac cctatatcag agctgaagtg gaggataaca ttatggtcac cttcagaaat     2700

caggcatcta ggccttacag tttttattca agcctgatct cttacgaaga ggaccagagg     2760

cagggagcag aaccacgaaa aaacttcgtg aagcctaatg agaccaaaac atacttttgg     2820

aaggtgcagc accatatggc cccaacaaaa gacgaattcg attgcaaggc atgggcctat     2880

ttttctgacg tggatctgga gaaggacgtc cacagtggcc tgatcgggcc actgctggtg     2940

tgtcatacta acaccctgaa tcccgcacac ggcaggcagg tcactgtcca ggaattcgcc     3000

ctgttcttta ccatctttga tgagacaaaa agctggtact tcaccgaaaa catggagcga     3060

aattgccggg ctccatgtaa tattcagatg gaagacccca cattcaagga gaactaccgc     3120

tttcatgcca tcaatgggta tattatggat actctgcccg gactggtcat ggctcaggac     3180

cagagaatca ggtggtacct gctgagcatg gggtccaacg agaatatcca ctcaattcat     3240

ttcagcggac acgtgtttac tgtccggaag aaagaagagt ataaaatggc cctgtacaac     3300

ctgtatcccg gcgtgttcga aaccgtcgag atgctgccta gcaaggcagg gatctggaga     3360

gtggaatgcc tgattgggga gcacctgcat gccggaatgt ctaccctgtt tctggtgtac     3420

agtaataagt gtcagacacc cctggggatg gcttccggac atatccggga tttccagatt     3480

accgcatctg gacagtacgg ccagtgggcc cctaagctgg ctagactgca ctattccggg     3540

tctatcaacg cttggtccac aaaagagcct ttctcttgga ttaaggtgga cctgctggca     3600

ccaatgatca ttcatggcat caaaactcag ggggccaggc agaagttctc ctctctgtac     3660

atctcacagt ttatcatcat gtacagcctg gatggcaaga aatggcagac ataccgcggc     3720

aatagcacag ggactctgat ggtgttcttt ggcaacgtgg acagttcagg gatcaagcac     3780

aacattttca atccccctat cattgctaga tacatcaggc tgcacccaac ccattattct     3840

attcgaagta cactgcggat ggaactgatg gggtgcgatc tgaacagttg ttcaatgccc     3900

ctgggaatgg agtccaaggc aatctctgac gcccagatta ccgctagctc ctacttcact     3960

aatatgtttg ctacctggag cccctccaaa gcacgactgc atctgcaggg acgaagcaac     4020

gcatggcgac cacaggtgaa caatcccaag gagtggctgc aggtcgattt tcagaaaact     4080

atgaaggtga ccggagtcac aactcagggc gtgaaaagtc tgctgacctc aatgtacgtc     4140

aaggagttcc tgatctctag ttcacaggac ggccaccagt ggacactgtt ctttcagaac     4200

ggaaaggtga aagtcttcca gggcaatcag gattccttta cacctgtggt caactctctg     4260

gacccacccc tgctgactcg ctacctgcga atccacccac agtcctgggt gcatcagatt     4320

gcactgagaa tggaagtcct gggctgcgag gcccaggacc tgtattga                  4368


<210>  6
<211>  4365
<212>  DNA
<213>  Adeno-associated virus

<400>  6
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagcgc gagatcaccc gcactaccct gcagagtgat     2340

caggaagaga tcgactacga cgatacaatt tctgtggaaa tgaagaaaga ggacttcgat     2400

atctatgacg aagatgagaa ccagagtcct cgatcattcc agaagaaaac ccggcattac     2460

tttattgctg cagtggagcg cctgtgggat tatggcatgt cctctagtcc tcacgtgctg     2520

cgaaatcggg cccagtcagg gagcgtccca cagttcaaga aagtggtctt ccaggagttt     2580

acagacggat cctttactca gccactgtac cggggcgaac tgaacgagca cctggggctg     2640

ctgggaccct atatcagagc tgaagtggag gataacatta tggtcacctt cagaaatcag     2700

gcatctaggc cttacagttt ttattcaagc ctgatctctt acgaagagga ccagaggcag     2760

ggagcagaac cacgaaaaaa cttcgtgaag cctaatgaga ccaaaacata cttttggaag     2820

gtgcagcacc atatggcccc aacaaaagac gaattcgatt gcaaggcatg ggcctatttt     2880

tctgacgtgg atctggagaa ggacgtccac agtggcctga tcgggccact gctggtgtgt     2940

catactaaca ccctgaatcc cgcacacggc aggcaggtca ctgtccagga attcgccctg     3000

ttctttacca tctttgatga gacaaaaagc tggtacttca ccgaaaacat ggagcgaaat     3060

tgccgggctc catgtaatat tcagatggaa gaccccacat tcaaggagaa ctaccgcttt     3120

catgccatca atgggtatat tatggatact ctgcccggac tggtcatggc tcaggaccag     3180

agaatcaggt ggtacctgct gagcatgggg tccaacgaga atatccactc aattcatttc     3240

agcggacacg tgtttactgt ccggaagaaa gaagagtata aaatggccct gtacaacctg     3300

tatcccggcg tgttcgaaac cgtcgagatg ctgcctagca aggcagggat ctggagagtg     3360

gaatgcctga ttggggagca cctgcatgcc ggaatgtcta ccctgtttct ggtgtacagt     3420

aataagtgtc agacacccct ggggatggct tccggacata tccgggattt ccagattacc     3480

gcatctggac agtacggcca gtgggcccct aagctggcta gactgcacta ttccgggtct     3540

atcaacgctt ggtccacaaa agagcctttc tcttggatta aggtggacct gctggcacca     3600

atgatcattc atggcatcaa aactcagggg gccaggcaga agttctcctc tctgtacatc     3660

tcacagttta tcatcatgta cagcctggat ggcaagaaat ggcagacata ccgcggcaat     3720

agcacaggga ctctgatggt gttctttggc aacgtggaca gttcagggat caagcacaac     3780

attttcaatc cccctatcat tgctagatac atcaggctgc acccaaccca ttattctatt     3840

cgaagtacac tgcggatgga actgatgggg tgcgatctga acagttgttc aatgcccctg     3900

ggaatggagt ccaaggcaat ctctgacgcc cagattaccg ctagctccta cttcactaat     3960

atgtttgcta cctggagccc ctccaaagca cgactgcatc tgcagggacg aagcaacgca     4020

tggcgaccac aggtgaacaa tcccaaggag tggctgcagg tcgattttca gaaaactatg     4080

aaggtgaccg gagtcacaac tcagggcgtg aaaagtctgc tgacctcaat gtacgtcaag     4140

gagttcctga tctctagttc acaggacggc caccagtgga cactgttctt tcagaacgga     4200

aaggtgaaag tcttccaggg caatcaggat tcctttacac ctgtggtcaa ctctctggac     4260

ccacccctgc tgactcgcta cctgcgaatc cacccacagt cctgggtgca tcagattgca     4320

ctgagaatgg aagtcctggg ctgcgaggcc caggacctgt attga                     4365


<210>  7
<211>  4371
<212>  DNA
<213>  Adeno-associated virus

<400>  7
atgcagattg agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct       60

actagaagat actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg      120

ggagagctgc cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac      180

accagcgtgg tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc      240

gctaagcctc ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac      300

gacaccgtgg tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg      360

ggcgtcagct actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga      420

gaaaaagagg acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg      480

aaagagaatg gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac      540

gtggacctgg tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa      600

gggagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg      660

tttgacgaag gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat      720

gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca      780

ctgcctggac tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc      840

accacacctg aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac      900

cgacaggcct ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg      960

gatctgggac agttcctgct gttttgccac atcagctccc accagcatga tggcatggag     1020

gcctacgtga aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag     1080

gaagctgaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat     1140

gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca     1200

tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca     1260

ccagacgatc gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga     1320

aagtacaaga aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca     1380

atccagcacg agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg     1440

ctgatcattt ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca     1500

gatgtgcgcc ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc     1560

ccaatcctgc ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc     1620

actaagagcg accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg     1680

gatctggcca gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag     1740

agaggcaacc agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa     1800

aaccggtcat ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg     1860

cagctggaag atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg     1920

ttcgacagtc tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc     1980

attggagcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa     2040

atggtgtatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc     2100

atggagaatc ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg     2160

atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat     2220

tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct     2280

tttagtcaga atcctccagt gctgaagagg caccaggaga tcacccgcac taccctgcag     2340

agtgatcagg aagagatcga ctacgacgat acaatttctg tggaaatgaa gaaagaggac     2400

ttcgatatct atgacgaaga tgagaaccag agtcctcgat cattccagaa gaaaacccgg     2460

cattacttta ttgctgcagt ggagcgcctg tgggattatg gcatgtcctc tagtcctcac     2520

gtgctgcgaa atcgggccca gtcagggagc gtcccacagt tcaagaaagt ggtcttccag     2580

gagtttacag acggatcctt tactcagcca ctgtaccggg gcgaactgaa cgagcacctg     2640

gggctgctgg gaccctatat cagagctgaa gtggaggata acattatggt caccttcaga     2700

aatcaggcat ctaggcctta cagtttttat tcaagcctga tctcttacga agaggaccag     2760

aggcagggag cagaaccacg aaaaaacttc gtgaagccta atgagaccaa aacatacttt     2820

tggaaggtgc agcaccatat ggccccaaca aaagacgaat tcgattgcaa ggcatgggcc     2880

tatttttctg acgtggatct ggagaaggac gtccacagtg gcctgatcgg gccactgctg     2940

gtgtgtcata ctaacaccct gaatcccgca cacggcaggc aggtcactgt ccaggaattc     3000

gccctgttct ttaccatctt tgatgagaca aaaagctggt acttcaccga aaacatggag     3060

cgaaattgcc gggctccatg taatattcag atggaagacc ccacattcaa ggagaactac     3120

cgctttcatg ccatcaatgg gtatattatg gatactctgc ccggactggt catggctcag     3180

gaccagagaa tcaggtggta cctgctgagc atggggtcca acgagaatat ccactcaatt     3240

catttcagcg gacacgtgtt tactgtccgg aagaaagaag agtataaaat ggccctgtac     3300

aacctgtatc ccggcgtgtt cgaaaccgtc gagatgctgc ctagcaaggc agggatctgg     3360

agagtggaat gcctgattgg ggagcacctg catgccggaa tgtctaccct gtttctggtg     3420

tacagtaata agtgtcagac acccctgggg atggcttccg gacatatccg ggatttccag     3480

attaccgcat ctggacagta cggccagtgg gcccctaagc tggctagact gcactattcc     3540

gggtctatca acgcttggtc cacaaaagag cctttctctt ggattaaggt ggacctgctg     3600

gcaccaatga tcattcatgg catcaaaact cagggggcca ggcagaagtt ctcctctctg     3660

tacatctcac agtttatcat catgtacagc ctggatggca agaaatggca gacataccgc     3720

ggcaatagca cagggactct gatggtgttc tttggcaacg tggacagttc agggatcaag     3780

cacaacattt tcaatccccc tatcattgct agatacatca ggctgcaccc aacccattat     3840

tctattcgaa gtacactgcg gatggaactg atggggtgcg atctgaacag ttgttcaatg     3900

cccctgggaa tggagtccaa ggcaatctct gacgcccaga ttaccgctag ctcctacttc     3960

actaatatgt ttgctacctg gagcccctcc aaagcacgac tgcatctgca gggacgaagc     4020

aacgcatggc gaccacaggt gaacaatccc aaggagtggc tgcaggtcga ttttcagaaa     4080

actatgaagg tgaccggagt cacaactcag ggcgtgaaaa gtctgctgac ctcaatgtac     4140

gtcaaggagt tcctgatctc tagttcacag gacggccacc agtggacact gttctttcag     4200

aacggaaagg tgaaagtctt ccagggcaat caggattcct ttacacctgt ggtcaactct     4260

ctggacccac ccctgctgac tcgctacctg cgaatccacc cacagtcctg ggtgcatcag     4320

attgcactga gaatggaagt cctgggctgc gaggcccagg acctgtattg a              4371


<210>  8
<211>  222
<212>  DNA
<213>  Adeno-associated virus

<400>  8
gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt       60

catattgact taggttactt attctccttt tgttgactaa gtcaataatc agaatcagca      120

ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg gtataaaagc      180

cccttcacca ggagaagccg tcacacagat ccacaagctc ct                         222


<210>  9
<211>  4778
<212>  DNA
<213>  Adeno-associated virus

<400>  9
gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt       60

catattgact taggttactt attctccttt tgttgactaa gtcaataatc agaatcagca      120

ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg gtataaaagc      180

cccttcacca ggagaagccg tcacacagat ccacaagctc ctgctagcag gtaagtgccg      240

tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta      300

ctgacactga catccacttt ttctttttct ccacaggttt aaacgccacc atgcagattg      360

agctgtcaac ttgctttttc ctgtgcctgc tgagattttg tttttccgct actagaagat      420

actacctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg ggagagctgc      480

cagtggacgc acgatttcca cctagagtcc ctaaatcatt ccccttcaac accagcgtgg      540

tctataagaa aacactgttc gtggagttta ctgatcacct gttcaacatc gctaagcctc      600

ggccaccctg gatgggactg ctgggaccaa caatccaggc agaggtgtac gacaccgtgg      660

tcattacact gaaaaacatg gcctcacacc ccgtgagcct gcatgctgtg ggcgtcagct      720

actggaaggc ttccgaaggg gcagagtatg acgatcagac ttcccagaga gaaaaagagg      780

acgataaggt gtttcctggc gggtctcata cctatgtgtg gcaggtcctg aaagagaatg      840

gccccatggc ttccgaccct ctgtgcctga cctactctta tctgagtcac gtggacctgg      900

tcaaggatct gaacagcgga ctgatcggag cactgctggt gtgtagggaa gggagcctgg      960

ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg tttgacgaag     1020

gaaaatcatg gcacagcgag acaaagaata gtctgatgca ggaccgggat gccgcttcag     1080

ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca ctgcctggac     1140

tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cggaatgggc accacacctg     1200

aagtgcactc cattttcctg gaggggcata cctttctggt ccgcaaccac cgacaggcct     1260

ccctggagat ctctccaatt accttcctga cagctcagac tctgctgatg gatctgggac     1320

agttcctgct gttttgccac atcagctccc accagcatga tggcatggag gcctacgtga     1380

aagtggacag ctgtcccgag gaacctcagc tgaggatgaa gaacaatgag gaagctgaag     1440

actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat gacgataaca     1500

gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca tgggtccatt     1560

acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca ccagacgatc     1620

gatcctacaa atctcagtat ctgaacaatg gaccacagcg gattggcaga aagtacaaga     1680

aagtgaggtt catggcttat accgatgaaa ccttcaagac tcgcgaagca atccagcacg     1740

agagcgggat tctgggacca ctgctgtacg gagaagtggg ggacaccctg ctgatcattt     1800

ttaagaacca ggccagcagg ccttacaata tctatccaca tggaattaca gatgtgcgcc     1860

ctctgtacag ccggagactg ccaaagggcg tcaaacacct gaaggacttc ccaatcctgc     1920

ccggggaaat ttttaagtat aaatggactg tcaccgtcga ggatggcccc actaagagcg     1980

accctaggtg cctgacccgc tactattcta gtttcgtgaa tatggaaagg gatctggcca     2040

gcggactgat cggcccactg ctgatttgtt acaaagagag cgtggatcag agaggcaacc     2100

agatcatgtc cgacaagagg aatgtgattc tgttcagtgt ctttgacgaa aaccggtcat     2160

ggtatctgac cgagaacatc cagagattcc tgcctaatcc agccggagtg cagctggaag     2220

atcctgagtt tcaggcttct aacatcatgc atagtattaa tggctacgtg ttcgacagtc     2280

tgcagctgtc agtgtgtctg cacgaggtcg cttactggta tatcctgagc attggagcac     2340

agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa atggtgtatg     2400

aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgtcc atggagaatc     2460

ccgggctgtg gatcctggga tgccacaaca gcgatttcag gaatcgcggg atgactgccc     2520

tgctgaaagt gtcaagctgt gacaagaaca ccggagacta ctatgaagat tcatacgagg     2580

acatcagcgc atatctgctg tccaaaaaca atgccattga acccaggtct tttagtcaga     2640

atcctccagt gctgaagagg caccagcgcg agatcacccg cactaccctg cagagtgatc     2700

aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag gacttcgata     2760

tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc cggcattact     2820

ttattgctgc agtggagcgc ctgtgggatt atggcatgtc ctctagtcct cacgtgctgc     2880

gaaatcgggc ccagtcaggg agcgtcccac agttcaagaa agtggtcttc caggagttta     2940

cagacggatc ctttactcag ccactgtacc ggggcgaact gaacgagcac ctggggctgc     3000

tgggacccta tatcagagct gaagtggagg ataacattat ggtcaccttc agaaatcagg     3060

catctaggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac cagaggcagg     3120

gagcagaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac ttttggaagg     3180

tgcagcacca tatggcccca acaaaagacg aattcgattg caaggcatgg gcctattttt     3240

ctgacgtgga tctggagaag gacgtccaca gtggcctgat cgggccactg ctggtgtgtc     3300

atactaacac cctgaatccc gcacacggca ggcaggtcac tgtccaggaa ttcgccctgt     3360

tctttaccat ctttgatgag acaaaaagct ggtacttcac cgaaaacatg gagcgaaatt     3420

gccgggctcc atgtaatatt cagatggaag accccacatt caaggagaac taccgctttc     3480

atgccatcaa tgggtatatt atggatactc tgcccggact ggtcatggct caggaccaga     3540

gaatcaggtg gtacctgctg agcatggggt ccaacgagaa tatccactca attcatttca     3600

gcggacacgt gtttactgtc cggaagaaag aagagtataa aatggccctg tacaacctgt     3660

atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggcagggatc tggagagtgg     3720

aatgcctgat tggggagcac ctgcatgccg gaatgtctac cctgtttctg gtgtacagta     3780

ataagtgtca gacacccctg gggatggctt ccggacatat ccgggatttc cagattaccg     3840

catctggaca gtacggccag tgggccccta agctggctag actgcactat tccgggtcta     3900

tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg ctggcaccaa     3960

tgatcattca tggcatcaaa actcaggggg ccaggcagaa gttctcctct ctgtacatct     4020

cacagtttat catcatgtac agcctggatg gcaagaaatg gcagacatac cgcggcaata     4080

gcacagggac tctgatggtg ttctttggca acgtggacag ttcagggatc aagcacaaca     4140

ttttcaatcc ccctatcatt gctagataca tcaggctgca cccaacccat tattctattc     4200

gaagtacact gcggatggaa ctgatggggt gcgatctgaa cagttgttca atgcccctgg     4260

gaatggagtc caaggcaatc tctgacgccc agattaccgc tagctcctac ttcactaata     4320

tgtttgctac ctggagcccc tccaaagcac gactgcatct gcagggacga agcaacgcat     4380

ggcgaccaca ggtgaacaat cccaaggagt ggctgcaggt cgattttcag aaaactatga     4440

aggtgaccgg agtcacaact cagggcgtga aaagtctgct gacctcaatg tacgtcaagg     4500

agttcctgat ctctagttca caggacggcc accagtggac actgttcttt cagaacggaa     4560

aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac tctctggacc     4620

cacccctgct gactcgctac ctgcgaatcc acccacagtc ctgggtgcat cagattgcac     4680

tgagaatgga agtcctgggc tgcgaggccc aggacctgta ttgagcggcc gcaataaaag     4740

atcagagctc tagagatctg tgtgttggtt ttttgtgt                             4778


<210>  10
<211>  4374
<212>  DNA
<213>  Adeno-associated virus

<400>  10
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggaattca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggaccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccagccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaagaaaacg gccccatggc ctccgaccct ctgtgcctga catacagcta cctgagccac      540

gtggacctcg tgaaggacct gaacagcggc ctgatcggag ccctgctcgt gtgtagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tctgtgtact ggcacgtgat cggcatgggc      840

accacccctg aggtgcacag catctttctg gaaggacaca cctttctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtactc tagaaggctg cccaagggcg tgaaacacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacacgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccggcctgat tggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gatcctgggc tgccacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccagaagc     2280

ttcagccaga acccccccgt gctgaagcgg caccagagag agatcacccg gaccaccctg     2340

cagtccgacc aggaagagat cgattacgac gacaccatca gcgtggaaat gaagaaagaa     2400

gatttcgaca tctacgacga ggacgagaac cagagccccc ggtcctttca gaaaaagacc     2460

cggcactact tcattgccgc tgtggaacgg ctgtgggact acggcatgag cagcagccct     2520

cacgtgctga gaaacagggc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2580

caggaattca cagacggcag cttcacccag cctctgtacc gcggcgagct gaatgagcac     2640

ctgggactgc tgggccccta tatcagagcc gaagtggaag ataacatcat ggtcaccttc     2700

cggaatcagg cctcccggcc ctacagcttc tacagctccc tgatcagcta cgaagaggac     2760

cagagacagg gcgctgagcc ccggaagaac ttcgtgaagc ccaacgagac taagacctac     2820

ttttggaagg tgcagcacca catggcccct acaaaggacg agttcgactg caaggcctgg     2880

gcctacttct ccgatgtgga cctggaaaag gacgtgcact ctgggctgat cggccccctg     2940

ctcgtgtgcc acaccaacac cctgaatccc gcccacggca gacaagtgac agtgcaggaa     3000

ttcgccctgt tcttcaccat cttcgacgaa acaaagagct ggtacttcac cgaaaacatg     3060

gaaagaaact gccgggctcc ctgcaacatc cagatggaag atcccacctt caaagagaac     3120

taccggttcc acgccatcaa cggctacatc atggacacac tgcccggcct cgtgatggct     3180

caggatcagc ggatccggtg gtatctgctg tccatgggct ccaacgagaa catccacagc     3240

atccacttca gcggccacgt gttcaccgtg cggaaaaaag aagagtacaa aatggccctg     3300

tacaacctgt accctggggt gttcgagaca gtggaaatgc tgcccagcaa ggccggcatc     3360

tggcgggtgg aatgtctgat cggcgagcat ctgcacgctg ggatgagcac actgtttctg     3420

gtgtacagca acaagtgcca gacacctctg ggcatggcct ctggccacat ccgggacttt     3480

cagatcacag ccagcggcca gtatggccag tgggccccaa aactggccag actgcactac     3540

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3600

ctggctccca tgatcatcca cggaatcaag acccagggcg ccagacagaa gttcagcagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

cggggcaata gcaccggcac cctgatggtg ttcttcggca acgtggactc cagcggcatt     3780

aagcacaaca tcttcaaccc ccccatcatt gcccggtaca tccggctgca ccccacccac     3840

tacagcatcc ggtccaccct gagaatggaa ctgatgggct gcgacctgaa ctcctgcagc     3900

atgcccctgg ggatggaaag caaggccatc tccgacgccc agatcaccgc ctccagctac     3960

ttcaccaaca tgttcgccac ctggtcccca tccaaggccc ggctgcatct gcagggcaga     4020

agcaatgctt ggaggcccca agtgaacaac cccaaagaat ggctgcaggt ggacttccag     4080

aaaaccatga aagtgaccgg cgtgaccacc cagggcgtga agtctctgct gacctctatg     4140

tacgtgaaag agttcctgat ctccagcagc caggacggcc accagtggac cctgtttttc     4200

cagaacggca aagtgaaagt gtttcagggg aaccaggact ccttcacccc cgtcgtgaat     4260

agcctggacc ctccactgct gaccagatac ctgcggatcc accctcagag ttgggtgcac     4320

cagattgctc tgcggatgga agtgctggga tgcgaggccc aggacctgta ctga           4374


<210>  11
<211>  4374
<212>  DNA
<213>  Adeno-associated virus

<400>  11
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg ctttagcgct       60

actagacgct actacctggg cgccgtggaa ctgagctggg actatatgca gtcagacctg      120

ggcgagctgc ccgtggacgc tagattccca cctagagtgc ctaagagctt cccctttaac      180

acctccgtgg tctataagaa aaccctgttc gtcgagttca ccgatcacct gtttaatatc      240

gctaagccta gacccccctg gatgggcctg ctgggcccta ctattcaggc cgaggtctac      300

gacaccgtcg tgatcaccct gaagaatatg gctagtcacc ccgtcagcct gcacgccgtg      360

ggcgtcagct actggaaggc tagcgagggc gccgagtacg acgatcagac tagtcagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggctctcaca cctacgtgtg gcaggtcctg      480

aaagaaaacg gccctatggc tagcgacccc ctgtgcctga cctatagcta cctgagtcac      540

gtggacctgg tcaaggacct gaatagcggc ctgatcggcg ccctgctcgt gtgtagagag      600

ggctcactgg ctaaagagaa aactcagacc ctgcacaagt ttatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcactcagag actaagaata gcctgatgca ggatagggac      720

gccgctagcg ctagagcctg gcctaagatg cacaccgtga acggctacgt gaacagatca      780

ctgcccggac tgatcggctg tcaccggaag tccgtctact ggcacgtgat cggaatgggc      840

actacccccg aggtgcactc tatctttctg gaaggccaca ccttcctcgt cagaaatcac      900

cggcaggcta gcctcgagat tagccctatc accttcctga ccgctcagac actgctgatg      960

gacctgggcc agttcctgct gttttgtcac attagctctc accagcacga cgggatggaa     1020

gcctacgtga aagtggatag ctgccccgag gaacctcagc tgagaatgaa gaacaacgag     1080

gaagccgagg attacgacga cgacctgacc gatagcgaga tggacgtcgt cagattcgac     1140

gacgataact cacctagctt tattcagatt agatcagtgg ctaagaagca ccctaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgata gaagctataa gtctcagtac ctgaacaacg gccctcagcg gatcggccgg     1320

aagtataaga aagtgcggtt tatggcctac accgacgaaa ccttcaagac tagagaggct     1380

attcagcacg agtcagggat cctgggcccc ctgctctacg gcgaagtggg cgacaccctg     1440

ctgattatct ttaagaatca ggctagtagg ccctataata tctaccccca cggaatcacc     1500

gacgtgcggc ccctctactc tagacggctg cctaagggcg tgaagcacct gaaggacttc     1560

cctattctgc ccggcgagat ctttaagtac aagtggaccg tgaccgtcga ggacggccct     1620

actaagtccg accctcggtg cctgactagg tactactcta gcttcgtgaa tatggaacgg     1680

gacctggcta gcggactgat tggccctctg ctgatctgct acaaagaatc agtggatcag     1740

cggggcaatc agattatgag cgataagcgg aacgtgatcc tgtttagtgt gtttgacgag     1800

aataggtcct ggtatctgac cgagaatatc cagcggttcc tgcctaaccc tgccggcgtg     1860

cagctggaag atcccgagtt tcaggctagc aatattatgc actctattaa cggatacgtg     1920

ttcgatagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta tatcctgtct     1980

atcggcgctc agaccgactt cctgagcgtg ttctttagcg gctacacctt taagcacaag     2040

atggtctacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gtttatgtct     2100

atggaaaacc ccggcctgtg gatcctgggg tgtcacaata gcgactttag gaatagagga     2160

atgaccgccc tgctgaaagt gtctagctgc gataagaaca ccggcgacta ttacgaggac     2220

tcttacgagg atattagcgc ctacctgctg tctaagaaca acgctatcga gcctagaagc     2280

ttcagtcaga acccccccgt gctgaagcgg caccagagag agatcactag aactaccctg     2340

cagagcgacc aggaagagat cgactacgac gacactatta gcgtcgagat gaagaaagag     2400

gatttcgata tctacgacga ggacgagaac cagtcaccta gatccttcca gaagaaaact     2460

aggcactact ttattgccgc cgtcgagcgg ctgtgggact acggaatgag ttctagccct     2520

cacgtgctga gaaatagggc tcagtcaggc tcagtgcctc agttcaagaa agtggtgttc     2580

caggaattca ccgacggcag cttcactcag cccctctata ggggcgagct gaacgagcac     2640

ctgggactgc tgggacctta tattagagcc gaagtcgagg acaatattat ggtcaccttt     2700

aggaaccagg cctctaggcc ctacagcttc tactctagcc tgatcagcta cgaggaagat     2760

cagcggcagg gggccgaacc tagaaagaac ttcgtgaagc ctaacgagac taagacctac     2820

ttctggaagg tgcagcacca catggcccct actaaggacg agttcgactg taaagcctgg     2880

gcctacttta gcgacgtgga cctcgagaag gacgtgcact cagggctgat cggacctctg     2940

ctcgtctgtc acactaacac cctgaacccc gctcacggcc ggcaggtcac agtgcaggaa     3000

ttcgccctgt tcttcactat cttcgacgaa actaagagct ggtacttcac agagaatatg     3060

gaaagaaact gtagggcccc ctgtaatatt cagatggaag atcctacctt taaagagaac     3120

tataggtttc acgctattaa cggctatatt atggacaccc tgcccggcct cgtgatggct     3180

caggatcagc ggattaggtg gtatctgctg tctatgggct ctaacgagaa tattcactct     3240

attcacttta gcggccacgt gttcaccgtc cggaagaaag aagagtataa gatggccctc     3300

tataacctct accccggcgt gttcgagaca gtggaaatgc tgcctagtaa agccggaatc     3360

tggcgggtcg agtgtctgat cggcgagcac ctccacgccg gaatgagcac cctgtttctg     3420

gtctactcta acaagtgtca gacccctctg ggaatggcta gcggccacat tagagacttt     3480

cagatcaccg ctagcggaca gtacggccag tgggccccta agctggctag actgcactat     3540

agcggatcta tcaacgcctg gtctaccaaa gagcccttta gctggattaa ggtggacctg     3600

ctggccccta tgattattca cgggattaag actcagggcg ctaggcagaa gtttagtagc     3660

ctctatatta gtcagtttat cattatgtat agcctggacg gcaagaagtg gcagacctat     3720

agaggcaata gcaccggcac cctgatggtg ttcttcggca acgtggactc tagcgggatc     3780

aagcacaata tctttaaccc ccctattatc gctagatata ttaggctgca ccctactcac     3840

tactctatta ggtctaccct gaggatggaa ctgatgggct gcgatctgaa tagctgctct     3900

atgcccctgg ggatggaatc taaggctatt agcgacgctc agatcacagc ctctagctac     3960

ttcactaata tgttcgctac ctggtcccct agcaaggccc ggctgcacct ccagggcaga     4020

tctaacgctt ggcggcctca ggtcaacaac cctaaagagt ggctgcaggt cgactttcag     4080

aaaactatga aggtcaccgg cgtgaccact cagggcgtga aatcactgct gacctctatg     4140

tacgtgaaag agttcctgat tagctctagc caggacggcc accagtggac cctgttcttt     4200

cagaacggca aagtgaaagt gtttcagggc aatcaggata gcttcacccc cgtggtcaat     4260

agcctggatc ccccactgct gactagatac ctgagaattc accctcagtc ttgggtgcac     4320

cagatcgccc tgagaatgga agtcctgggc tgtgaagctc aggacctcta ctaa           4374


