                         SEQUENCE LISTING

<110>  Baxalta GmbH
       Baxalta Incorporated
 
<120>  Production of Fully Processed and Functional Factor X in a 
       Furin-Secreting Mammalian Expression System

<130>  3724526.00092WO

<150>  US62/036,438
<151>  2014-08-12

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  7981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RCL.012-74.pD3H-Furin expression vector

<400>  1
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattctgc      960

agatatccag cacagtggcg gccgcatgga gctgaggccc tggttgctat gggtggtagc     1020

agcaacagga accttggtcc tgctagcagc tgatgctcag ggccagaagg tcttcaccaa     1080

cacgtgggct gtgcgcatcc ctggaggccc agcggtggcc aacagtgtgg cacggaagca     1140

tgggttcctc aacctgggcc agatcttcgg ggactattac cacttctggc atcgaggagt     1200

gacgaagcgg tccctgtcgc ctcaccgccc gcggcacagc cggctgcaga gggagcctca     1260

agtacagtgg ctggaacagc aggtggcaaa gcgacggact aaacgggacg tgtaccagga     1320

gcccacagac cccaagtttc ctcagcagtg gtacctgtct ggtgtcactc agcgggacct     1380

gaatgtgaag gcggcctggg cgcagggcta cacagggcac ggcattgtgg tctccattct     1440

ggacgatggc atcgagaaga accacccgga cttggcaggc aattatgatc ctggggccag     1500

ttttgatgtc aatgaccagg accctgaccc ccagcctcgg tacacacaga tgaatgacaa     1560

caggcacggc acacggtgtg cgggggaagt ggctgcggtg gccaacaacg gtgtctgtgg     1620

tgtaggtgtg gcctacaacg cccgcattgg aggggtgcgc atgctggatg gcgaggtgac     1680

agatgcagtg gaggcacgct cgctgggcct gaaccccaac cacatccaca tctacagtgc     1740

cagctggggc cccgaggatg acggcaagac agtggatggg ccagcccgcc tcgccgagga     1800

ggccttcttc cgtggggtta gccagggccg aggggggctg ggctccatct ttgtctgggc     1860

ctcggggaac gggggccggg aacatgacag ctgcaactgc gacggctaca ccaacagtat     1920

ctacacgctg tccatcagca gcgccacgca gtttggcaac gtgccgtggt acagcgaggc     1980

ctgctcgtcc acactggcca cgacctacag cagtggcaac cagaatgaga agcagatcgt     2040

gacgactgac ttgcggcaga agtgcacgga gtctcacacg ggcacctcag cctctgcccc     2100

cttagcagcc ggcatcattg ctctcaccct ggaggccaat aagaacctca catggcggga     2160

catgcaacac ctggtggtac agacctcgaa gccagcccac ctcaatgcca acgactgggc     2220

caccaatggt gtgggccgga aagtgagcca ctcatatggc tacgggcttt tggacgcagg     2280

cgccatggtg gccctggccc agaattggac cacagtggcc ccccagcgga agtgcatcat     2340

cgacatcctc accgagccca aagacatcgg gaaacggctc gaggtgcgga agaccgtgac     2400

cgcgtgcctg ggcgagccca accacatcac tcggctggag cacgctcagg cgcggctcac     2460

cctgtcctat aatcgccgtg gcgacctggc catccacctg gtcagcccca tgggcacccg     2520

ctccaccctg ctggcagcca ggccacatga ctactccgca gatgggttta atgactgggc     2580

cttcatgaca actcattcct gggatgagga tccctctggc gagtgggtcc tagagattga     2640

aaacaccagc gaagccaaca actatgggac gctgaccaag ttcaccctcg tactctatgg     2700

caccgcccct gaggggctgc ccgtacctcc agaaagcagt ggctgcaaga ccctcacgtc     2760

cagtcaggcc tgtgtggtgt gcgaggaagg cttctccctg caccagaaga gctgtgtcca     2820

gcactgccct ccaggcttcg ccccccaagt cctcgatacg cactatagca ccgagaatga     2880

cgtggagacc atccgggcca gcgtctgcgc cccctgccac gcctcatgtg ccacatgcca     2940

ggggccggcc ctgacagact gcctcagctg ccccagccac gcctccttgg accctgtgga     3000

gcagacttgc tcccggcaaa gccagagcag ccgagagtcc ccgccacagc agcagccacc     3060

tcggctgccc ccggaggtgg aggcggggca acggctgcgg gcagggctgc tgccctcaca     3120

cctgcctgag gtggtggccg gcctcagctg cgccttcatc gtgctggtct tcgtcactgt     3180

cttcctggtc ctgcagctgc gctctggctt tagttttcgg ggggtgaagg tgtacaccat     3240

ggaccgtggc ctcatctcct acaaggggct gccccctgaa gcctggcagg aggagtgccc     3300

gtctgactca gaagaggacg agggccgggg cgagaggacc gcctttatca aagaccagag     3360

cgccctctga tctagagggc ccgtttaaac ccgctgatca gcctcgactg tgccttctag     3420

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3480

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     3540

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     3600

caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa ccagctgggg     3660

ctctaggggg tatccccacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     3720

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     3780

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc ggggcatccc     3840

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     3900

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     3960

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     4020

ctattctttt gatttataag ggattttggg gatttcggcc tattggttaa aaaatgagct     4080

gatttaacaa aaatttaacg cgaattaatt ctgtggaatg tgtgtcagtt agggtgtgga     4140

aagtccccag gctccccagg caggcagaag tatgcaaagc atgcatctca attagtcagc     4200

aaccaggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct     4260

caattagtca gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc     4320

cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga     4380

ggccgcctct gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg     4440

cttttgcaaa aagctcccgg gagcttgtat atccattttc ggatctgatc agcacgtgat     4500

gaaaaagcct gaactcaccg cgacgtctgt cgagaagttt ctgatcgaaa agttcgacag     4560

cgtctccgac ctgatgcagc tctcggaggg cgaagaatct cgtgctttca gcttcgatgt     4620

aggagggcgt ggatatgtcc tgcgggtaaa tagctgcgcc gatggtttct acaaagatcg     4680

ttatgtttat cggcactttg catcggccgc gctcccgatt ccggaagtgc ttgacattgg     4740

ggaattcagc gagagcctga cctattgcat ctcccgccgt gcacagggtg tcacgttgca     4800

agacctgcct gaaaccgaac tgcccgctgt tctgcagccg gtcgcggagg ccatggatgc     4860

gatcgctgcg gccgatctta gccagacgag cgggttcggc ccattcggac cgcaaggaat     4920

cggtcaatac actacatggc gtgatttcat atgcgcgatt gctgatcccc atgtgtatca     4980

ctggcaaact gtgatggacg acaccgtcag tgcgtccgtc gcgcaggctc tcgatgagct     5040

gatgctttgg gccgaggact gccccgaagt ccggcacctc gtgcacgcgg atttcggctc     5100

caacaatgtc ctgacggaca atggccgcat aacagcggtc attgactgga gcgaggcgat     5160

gttcggggat tcccaatacg aggtcgccaa catcttcttc tggaggccgt ggttggcttg     5220

tatggagcag cagacgcgct acttcgagcg gaggcatccg gagcttgcag gatcgccgcg     5280

gctccgggcg tatatgctcc gcattggtct tgaccaactc tatcagagct tggttgacgg     5340

caatttcgat gatgcagctt gggcgcaggg tcgatgcgac gcaatcgtcc gatccggagc     5400

cgggactgtc gggcgtacac aaatcgcccg cagaagcgcg gccgtctgga ccgatggctg     5460

tgtagaagta ctcgccgata gtggaaaccg acgccccagc actcgtccga gggcaaagga     5520

atagcacgtg ctacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg     5580

aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt     5640

cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     5700

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     5760

catcaatgta tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc     5820

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     5880

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     5940

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     6000

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     6060

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     6120

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     6180

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     6240

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     6300

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     6360

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     6420

atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     6480

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     6540

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     6600

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     6660

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     6720

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     6780

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     6840

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     6900

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     6960

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     7020

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     7080

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     7140

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     7200

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     7260

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     7320

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     7380

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     7440

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     7500

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     7560

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     7620

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     7680

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     7740

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     7800

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     7860

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     7920

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt     7980

c                                                                     7981


<210>  2
<211>  2385
<212>  DNA
<213>  Homo sapiens

<400>  2
atggagctga ggccctggtt gctatgggtg gtagcagcaa caggaacctt ggtcctgcta       60

gcagctgatg ctcagggcca gaaggtcttc accaacacgt gggctgtgcg catccctgga      120

ggcccagcgg tggccaacag tgtggcacgg aagcatgggt tcctcaacct gggccagatc      180

ttcggggact attaccactt ctggcatcga ggagtgacga agcggtccct gtcgcctcac      240

cgcccgcggc acagccggct gcagagggag cctcaagtac agtggctgga acagcaggtg      300

gcaaagcgac ggactaaacg ggacgtgtac caggagccca cagaccccaa gtttcctcag      360

cagtggtacc tgtctggtgt cactcagcgg gacctgaatg tgaaggcggc ctgggcgcag      420

ggctacacag ggcacggcat tgtggtctcc attctggacg atggcatcga gaagaaccac      480

ccggacttgg caggcaatta tgatcctggg gccagttttg atgtcaatga ccaggaccct      540

gacccccagc ctcggtacac acagatgaat gacaacaggc acggcacacg gtgtgcgggg      600

gaagtggctg cggtggccaa caacggtgtc tgtggtgtag gtgtggccta caacgcccgc      660

attggagggg tgcgcatgct ggatggcgag gtgacagatg cagtggaggc acgctcgctg      720

ggcctgaacc ccaaccacat ccacatctac agtgccagct ggggccccga ggatgacggc      780

aagacagtgg atgggccagc ccgcctcgcc gaggaggcct tcttccgtgg ggttagccag      840

ggccgagggg ggctgggctc catctttgtc tgggcctcgg ggaacggggg ccgggaacat      900

gacagctgca actgcgacgg ctacaccaac agtatctaca cgctgtccat cagcagcgcc      960

acgcagtttg gcaacgtgcc gtggtacagc gaggcctgct cgtccacact ggccacgacc     1020

tacagcagtg gcaaccagaa tgagaagcag atcgtgacga ctgacttgcg gcagaagtgc     1080

acggagtctc acacgggcac ctcagcctct gcccccttag cagccggcat cattgctctc     1140

accctggagg ccaataagaa cctcacatgg cgggacatgc aacacctggt ggtacagacc     1200

tcgaagccag cccacctcaa tgccaacgac tgggccacca atggtgtggg ccggaaagtg     1260

agccactcat atggctacgg gcttttggac gcaggcgcca tggtggccct ggcccagaat     1320

tggaccacag tggcccccca gcggaagtgc atcatcgaca tcctcaccga gcccaaagac     1380

atcgggaaac ggctcgaggt gcggaagacc gtgaccgcgt gcctgggcga gcccaaccac     1440

atcactcggc tggagcacgc tcaggcgcgg ctcaccctgt cctataatcg ccgtggcgac     1500

ctggccatcc acctggtcag ccccatgggc acccgctcca ccctgctggc agccaggcca     1560

catgactact ccgcagatgg gtttaatgac tgggccttca tgacaactca ttcctgggat     1620

gaggatccct ctggcgagtg ggtcctagag attgaaaaca ccagcgaagc caacaactat     1680

gggacgctga ccaagttcac cctcgtactc tatggcaccg cccctgaggg gctgcccgta     1740

cctccagaaa gcagtggctg caagaccctc acgtccagtc aggcctgtgt ggtgtgcgag     1800

gaaggcttct ccctgcacca gaagagctgt gtccagcact gccctccagg cttcgccccc     1860

caagtcctcg atacgcacta tagcaccgag aatgacgtgg agaccatccg ggccagcgtc     1920

tgcgccccct gccacgcctc atgtgccaca tgccaggggc cggccctgac agactgcctc     1980

agctgcccca gccacgcctc cttggaccct gtggagcaga cttgctcccg gcaaagccag     2040

agcagccgag agtccccgcc acagcagcag ccacctcggc tgcccccgga ggtggaggcg     2100

gggcaacggc tgcgggcagg gctgctgccc tcacacctgc ctgaggtggt ggccggcctc     2160

agctgcgcct tcatcgtgct ggtcttcgtc actgtcttcc tggtcctgca gctgcgctct     2220

ggctttagtt ttcggggggt gaaggtgtac accatggacc gtggcctcat ctcctacaag     2280

gggctgcccc ctgaagcctg gcaggaggag tgcccgtctg actcagaaga ggacgagggc     2340

cggggcgaga ggaccgcctt tatcaaagac cagagcgccc tctga                     2385


<210>  3
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin consensus recognition site


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is any amino acid, or no amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X is Lysine or Arginine

<400>  4

Arg Xaa Xaa Arg 
1               


