                         SEQUENCE LISTING

<110>  Delinia, Inc.
       Greve, Jeffrey
 
<120>  MODIFIED IL-2 VARIANTS THAT SELECTIVELY ACTIVATE REGULATORY T 
       CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES

<130>  98210-950525

<140>  WO PCT/US2015/044462
<141>  2015-08-10

<150>  US 62/070,016
<151>  2014-08-11

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  2
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic variant IL-2 polynucleotide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Cys

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Lys or Cys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Asp or His

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Tyr or Phe

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is Lys or Cys

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa is Lys or Cys

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa is Thr, Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa is Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa is Asn, Arg, Ile or Gly

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa is Lys or Cys

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa is Gly or Cys

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa is Phe or Cys

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa is Met or Cys

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa is Glu and Cys

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  Xaa is Asp or Cys

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa is Gln, Leu or Phe

<400>  2

Ala Pro Xaa Ser Ser Xaa Thr Xaa Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Xaa Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Xaa Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Xaa 
        35                  40                  45              


Xaa Ala Xaa Glu Leu Lys His Leu Xaa Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Xaa Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Xaa Xaa Ser Xaa Thr Thr Xaa Xaa Cys Xaa Tyr Ala Xaa Glu Xaa Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Xaa Xaa Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


