                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  ANTI-OSPA ANTIBODIES AND METHODS OF USE

<130>  50720-012WO3

<150>  US 62/162,279
<151>  2015-05-15

<150>  US 62/035,960
<151>  2014-08-11

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  71
<212>  PRT
<213>  Borrelia burgdorferi

<400>  1

Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val 
1               5                   10                  15      


Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe 
            20                  25                  30          


Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp 
        35                  40                  45              


Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu 
    50                  55                  60                  


Lys Ile Ile Thr Arg Ala Asp 
65                  70      


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Ser or Lys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Thr or Ser

<400>  2

Gly Tyr Xaa Phe Xaa Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  3
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Phe or Ile

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Tyr or Phe

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Thr or Lys

<400>  3

Xaa Ile Xaa Pro Gly Asp Ser Asp Xaa Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Arg Gly Ile Leu Arg Tyr Phe Asp Trp Phe Leu Asp Tyr 
1               5                   10                  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Arg His Ile Thr Thr His Thr Tyr Arg Gly Phe Phe Asp Phe 
1               5                   10                  15  


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is Gly or Asp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Gly or Ala

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Ser or Leu

<400>  6

Arg Ala Ser Gln Xaa Ile Ser Ser Xaa Xaa Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Val Ser Ser Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Phe Asn Ser Tyr Leu Leu Thr 
1               5                   


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Gln Phe Asn Gly Tyr Pro His Arg Leu Thr 
1               5                   10      


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Phe Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ala Ser Gln Gly Ile Ser Ser Gly Ser Ala 
1               5                   10      


<210>  13
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Val Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Arg Val 
        35                  40                  45              


Gly Phe Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Leu Arg Tyr Phe Asp Trp Phe Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Gly 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Leu Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  35
<212>  PRT
<213>  Borrelia burgdorferi

<400>  15

Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val 
1               5                   10                  15      


Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe 
            20                  25                  30          


Lys Glu Asp 
        35  


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Tyr Lys Phe Ser Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  17
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Ile Phe Pro Gly Asp Ser Asp Lys Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  19
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Glu Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Lys Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Phe Pro Gly Asp Ser Asp Lys Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ile Thr Thr His Thr Tyr Arg Gly Phe Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Gly Tyr Pro His 
                85                  90                  95      


Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  21
<211>  36
<212>  PRT
<213>  Borrelia burgdorferi

<400>  21

Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
1               5                   10                  15      


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
            20                  25                  30          


Thr Arg Ala Asp 
        35      


<210>  22
<211>  96
<212>  PRT
<213>  Borrelia burgdorferi

<400>  22

Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys 
1               5                   10                  15      


Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala 
            20                  25                  30          


Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile 
        35                  40                  45              


Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu Asn 
    50                  55                  60                  


Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly 
65                  70                  75                  80  


Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                85                  90                  95      


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Tyr Ile Phe Ala Thr Tyr Trp Ile Gly 
1               5                   10  


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Ile Ile Tyr Pro Asn Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Arg Thr Arg Trp Tyr Phe Asp Leu 
1               5                   


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  29
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Ala Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Asn Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Arg Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  31
<211>  36
<212>  PRT
<213>  Borrelia burgdorferi

<400>  31

Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys 
1               5                   10                  15      


Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala 
            20                  25                  30          


Glu Lys Thr Thr 
        35      


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Phe Thr Phe Arg Asn Tyr Trp Met Asp 
1               5                   10  


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  33

Asn Ile Lys Gln Asp Gly Ser Val Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Arg Asp Gly Tyr Ser Gly Tyr Asp Ser Val Gly Phe Asp Ile 
1               5                   10                  15  


<210>  35
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Thr Ser Ser Arg Ala Thr 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  38
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Val Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Gly Tyr Asp Ser Val Gly Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ser Asp Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  40
<211>  273
<212>  PRT
<213>  Borrelia burgdorferi

<400>  40

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 
        35                  40                  45              


Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 
65                  70                  75                  80  


Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 
                85                  90                  95      


Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 
                165                 170                 175     


Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 
            180                 185                 190         


Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 
        195                 200                 205             


Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 
                245                 250                 255     


Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  41
<211>  273
<212>  PRT
<213>  Borrelia afzelii

<400>  41

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu Gly Thr Lys 
65                  70                  75                  80  


Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Leu Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 
            100                 105                 110         


Lys Val Ser Ser Lys Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 
                165                 170                 175     


Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ala 
            180                 185                 190         


Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln 
        195                 200                 205             


Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  42
<211>  273
<212>  PRT
<213>  Borrelia garinii

<400>  42

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Ser Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Glu Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Asn Ser Lys Asp Lys Ser Ser Ile Glu Glu Lys Phe Asn Ala 
        115                 120                 125             


Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Ala Leu Glu Gly Thr Leu Ala Ala Asp Lys Thr 
                165                 170                 175     


Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys His Ile Pro 
            180                 185                 190         


Asn Ser Gly Glu Ile Thr Val Glu Leu Asn Asp Ser Asn Ser Thr Gln 
        195                 200                 205             


Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  43
<211>  256
<212>  PRT
<213>  Borrelia burgdorferi

<400>  43

Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp 
1               5                   10                  15      


Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys Asp 
            20                  25                  30          


Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys Gly 
        35                  40                  45              


Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala 
    50                  55                  60                  


Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr 
65                  70                  75                  80  


Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys 
                85                  90                  95      


Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys 
            100                 105                 110         


Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu 
        115                 120                 125             


Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu Val 
    130                 135                 140                 


Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr Thr 
145                 150                 155                 160 


Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys 
                165                 170                 175     


Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala 
            180                 185                 190         


Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile 
        195                 200                 205             


Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu Asn 
    210                 215                 220                 


Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly 
225                 230                 235                 240 


Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                245                 250                 255     


<210>  44
<211>  124
<212>  PRT
<213>  Borrelia burgdorferi

<400>  44

Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp 
1               5                   10                  15      


Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys Asp 
            20                  25                  30          


Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys Gly 
        35                  40                  45              


Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala 
    50                  55                  60                  


Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr 
65                  70                  75                  80  


Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys 
                85                  90                  95      


Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys 
            100                 105                 110         


Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp 
        115                 120                 


<210>  45
<211>  160
<212>  PRT
<213>  Borrelia burgdorferi

<400>  45

Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp 
1               5                   10                  15      


Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys Asp 
            20                  25                  30          


Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys Gly 
        35                  40                  45              


Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala 
    50                  55                  60                  


Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr 
65                  70                  75                  80  


Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys 
                85                  90                  95      


Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys 
            100                 105                 110         


Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu 
        115                 120                 125             


Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu Val 
    130                 135                 140                 


Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr Thr 
145                 150                 155                 160 


<210>  46
<211>  203
<212>  PRT
<213>  Borrelia burgdorferi

<400>  46

Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val 
1               5                   10                  15      


Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe 
            20                  25                  30          


Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp 
        35                  40                  45              


Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu 
    50                  55                  60                  


Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile 
65                  70                  75                  80  


Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Val 
                85                  90                  95      


Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr Thr Leu Val Val Lys Glu 
            100                 105                 110         


Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser 
        115                 120                 125             


Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala 
    130                 135                 140                 


Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys 
145                 150                 155                 160 


Lys Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln 
                165                 170                 175     


Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile 
            180                 185                 190         


Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
        195                 200             


<210>  47
<211>  168
<212>  PRT
<213>  Borrelia burgdorferi

<400>  47

Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser 
1               5                   10                  15      


Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile 
            20                  25                  30          


Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp 
        35                  40                  45              


Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly 
    50                  55                  60                  


Thr Leu Thr Ala Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val 
65                  70                  75                  80  


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu 
                85                  90                  95      


Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 
            100                 105                 110         


Ser Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys 
        115                 120                 125             


Asp Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp 
    130                 135                 140                 


Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu 
145                 150                 155                 160 


Asp Glu Ile Lys Asn Ala Leu Lys 
                165             


<210>  48
<211>  132
<212>  PRT
<213>  Borrelia burgdorferi

<400>  48

Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys 
1               5                   10                  15      


Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala 
            20                  25                  30          


Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys 
        35                  40                  45              


Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp 
    50                  55                  60                  


Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser 
65                  70                  75                  80  


Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe 
                85                  90                  95      


Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr 
            100                 105                 110         


Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys 
        115                 120                 125             


Asn Ala Leu Lys 
    130         


<210>  49
<211>  96
<212>  PRT
<213>  Borrelia burgdorferi

<400>  49

Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys 
1               5                   10                  15      


Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala 
            20                  25                  30          


Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile 
        35                  40                  45              


Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu Asn 
    50                  55                  60                  


Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly 
65                  70                  75                  80  


Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 
                85                  90                  95      


