                         SEQUENCE LISTING

<110>  GENEXINE, INC.
       Hyun-Tak, JIN
       Hye Seong, LIM
       You Suk, SUH
       Eun Joo, NAM
 
<120>  Methods of Treating Cervical Cancer

<130>  2629.003PC02/C-K/BMB

<150>  62/039,270
<151>  2014-08-19

<150>  62/038,134
<151>  2014-08-15

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  477
<212>  DNA
<213>  Human papillomavirus 16


<220>
<221>  misc_feature
<223>  E6 nucleotide sequence

<400>  1
atgcaccaaa agagaactgc aatgtttcag gacccacagg agcgacccag aaagttacca       60

catttatgca cagagctgca aacaactata catgatataa tattagaatg tgtgtactgc      120

aagcaacagt tactgcgacg tgaggtatat gactttgctt ttcgggattt atgcatagta      180

tatagagatg ggaatccata tgcagtgtgt gataaatgtt taaagtttta ttctaaaatt      240

agtgagtata gatattattg ttatagtgtg tatggaacaa cattagaaca gcaatacaac      300

aaaccgttgt gtgatttgtt aattaggtgt attaactgtc aaaagccact gtgtcctgaa      360

gaaaagcaaa gacatctgga caaaaagcaa agattccata atataagggg tcggtggacc      420

ggtcgatgta tgtcttgttg cagatcatca agaacacgta gagaaaccca gctgtaa         477


<210>  2
<211>  158
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  E6 protein

<400>  2

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro His Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  3
<211>  477
<212>  DNA
<213>  Human papillomavirus 18


<220>
<221>  misc_feature
<223>  E6 nucleotide sequence

<400>  3
atggcgcgct ttgaggatcc aacacggcga ccctacaagc tacctgatct gtgcacggaa       60

ctgaacactt cactgcaaga catagaaata acctgtgtat attgcaagac agtattggaa      120

cttacagagg tatttgaatt tgcattcaaa gatttatttg tagtgtatag agacagtata      180

ccgcatgctg catgccataa atgtatagat ttctattcta gaattagaga attaagatat      240

tattcagact ctgtgtatgg agacacatta gaaaaactaa ctaacactgg gttatacaat      300

ttattaataa ggtgcctgcg gtgccagaaa ccgttgaatc cagcagaaaa acttagacac      360

cttaatgaaa aacgacgatt ccacaaaata gctgggcact atagaggcca gtgccattcg      420

tgctgcaacc gagcacgaca ggagagactc caacgacgca gagaaacaca agtataa         477


<210>  4
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  E6 protein

<400>  4

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Lys Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  5
<211>  297
<212>  DNA
<213>  Human papillomavirus 16


<220>
<221>  misc_feature
<223>  E7 nucleotide sequence

<400>  5
atgcatggag atacacctac attgcatgaa tatatgttag atttgcaacc agagacaact       60

gatctctact gttatgagca attaaatgac agctcagagg aggaggatga aatagatggt      120

ccagctggac aagcagaacc ggacagagcc cattacaata ttgtaacctt ttgttgcaag      180

tgtgactcta cgcttcggtt gtgcgtacaa agcacacacg tagacattcg tactttggaa      240

gacctgttaa tgggcacact aggaattgtg tgccccatct gttctcagaa accataa         297


<210>  6
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  E7 protein

<400>  6

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  7
<211>  318
<212>  DNA
<213>  Human papillomavirus 18


<220>
<221>  misc_feature
<223>  E7 nucleotide sequence

<400>  7
atgtatggac ctaaggcaac attgcaagac attgtattgc atttagagcc tcaaaatgaa       60

attccggttg accttctatg tcacgagcaa ttaagcgact cagaggaaga aaacgatgaa      120

atagatggag ttaatcatca acatttacca gcccgacgag ccgaaccaca acgtcacaca      180

atgttgtgta tgtgttgtaa gtgtgaagcc agaattgagc tagtagtaga aagctcagca      240

gacgaccttc gagcattcca gcagctgttt ctgagcaccc tgtcctttgt gtgtccgtgg      300

tgtgcatccc agcagtaa                                                    318


<210>  8
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  E7 protein

<400>  8

Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  9
<211>  1737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized sequence of GX-188 without FLT3L and signal 
       peptide

<400>  9
atgcaccaga agagaaccgc catgttccag gaccctcagg agagacctag gaagctgcct       60

cacctgtgta cagagctcca gacaaccatc cacgacatca tcctggagtg cgtgtactgt      120

aagcagcagc tgctgagaag agaggtgtac gacttcgcct tcagagacct gtgcatcgtg      180

tacagagacg gcaaccctta cgccgtgtgc gataagtgtc tgaagttcta ttccaaaatc      240

tccgaatata ggtacatgca cggcgacacc cctaccctgc acgagtacat gctggacctc      300

cagcctgaga ccacagacct gtactgctac gagcagctga acgacagctc tgaggaagag      360

gacgagattg acggacctgc tggccaggcc gagcctgaca gagcccacta caatatcgtg      420

acattctgtt gcaaatgcga ctccacactg gacaagtgcc tgaagttcta cagcaagatc      480

tctgagtaca gatactactg ctactctgtg tacggcacca cactggagca gcagtacaac      540

aagcctctgt gcgacctcct gatccgctgc atcaactgcc agaagcctct gtgccctgag      600

gagaagcaga gacacctgga caagaagcag cggttccaca acatcagagg cagatggacc      660

ggcaggtgca tgtcctgctg tagatcctcc agaaccagac gggagaccca gctgcactac      720

aacatcgtga ccttctgctg caagtgcgac tctaccctga gactgtgcgt gcagtctacc      780

cacgtggaca tcagaaccct ggaggacctg ctgatgggca ccctgggcat cgtgtgccct      840

atctgctctc agaagcctat ggccaggttc gaggacccta ccagaagacc ctacaagctg      900

cctgacctgt gcaccgagct gaacacctct ctgcaagaca tcgagatcac ctgcgtgtac      960

tgcaagaccg tgctggagct gaccgaggtg ttcgagttcg ccttcaagga cctgttcgtg     1020

gtgtacagag acagcatccc tcacgctgcc tgccacaagt gcatcgactt ctattccagg     1080

atcagggagc tgcgctatta ctccgactct gtgatgtacg gccccaaggc caccctccag     1140

gacatcgtgc tgcacctgga gcctcagaac gagatccccg tggacctgct gtgccacgag     1200

cagctgtctg actctgaaga ggagaacgac gagatcgacg gcgtgaacca ccagcacctg     1260

cctgccagga gagctgaacc ccagcggcat accatgctgt gtatgtgctt ctactctagg     1320

atcagagagc tgaggtacta ctctgactct gtgtacggcg acaccctgga gaagctgacc     1380

aacaccggcc tgtacaacct gctgatccgg tgcctgaggt gccagaagcc tctgaaccct     1440

gccgagaagc tgagacacct gaacgagaag agaagattcc acaagatcgc tggccactac     1500

agaggccagt gccactcttg ctgcaacaga gccagacagg agagactcca gcggagaagg     1560

gagacccagg tggccagaag agccgagcct cagagacaca ccatgctgtg catgtgctgc     1620

aagtgcgagg ccagaatcga gctggtggtg gagagctctg ccgacgacct gagagccttc     1680

cagcagctgt tcctgtctac cctgagcttc gtgtgccctt ggtgcgcctc tcagcag        1737


<210>  10
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of GX-188 without FLT3L and signal peptide

<400>  10

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro His Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg Tyr Met His Gly Asp Thr Pro Thr Leu His Glu Tyr 
                85                  90                  95      


Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln 
            100                 105                 110         


Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly 
        115                 120                 125             


Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys 
    130                 135                 140                 


Lys Cys Asp Ser Thr Leu Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
145                 150                 155                 160 


Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu 
                165                 170                 175     


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            180                 185                 190         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        195                 200                 205             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    210                 215                 220                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu His Tyr 
225                 230                 235                 240 


Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys 
                245                 250                 255     


Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met 
            260                 265                 270         


Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Met Ala 
        275                 280                 285             


Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys 
    290                 295                 300                 


Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr 
305                 310                 315                 320 


Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys 
                325                 330                 335     


Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His 
            340                 345                 350         


Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser 
        355                 360                 365             


Asp Ser Val Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu 
    370                 375                 380                 


His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu 
385                 390                 395                 400 


Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn 
                405                 410                 415     


His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met 
            420                 425                 430         


Leu Cys Met Cys Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser 
        435                 440                 445             


Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu 
    450                 455                 460                 


Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro 
465                 470                 475                 480 


Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile 
                485                 490                 495     


Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg 
            500                 505                 510         


Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala 
        515                 520                 525             


Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala 
    530                 535                 540                 


Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe 
545                 550                 555                 560 


Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala 
                565                 570                 575     


Ser Gln Gln 
            


<210>  11
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of FLT3L  (fms-like tyrosine kinase-3 ligand)

<400>  11
atcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc       60

cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag      120

gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg      180

ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata      240

cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc      300

aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc      360

actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg      420

ccacccccat ggagtccccg gcccctggag gccacagccc cgacagcccc gggcggcggc      480

agcggcgat                                                              489


<210>  12
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of FLT3L  (fms-like tyrosine kinase-3 ligand)

<400>  12

Ile Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 
1               5                   10                  15      


Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 
            20                  25                  30          


Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 
        35                  40                  45              


Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 
    50                  55                  60                  


Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 
65                  70                  75                  80  


His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 
                85                  90                  95      


Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 
            100                 105                 110         


Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 
        115                 120                 125             


Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp 
    130                 135                 140                 


Ser Pro Arg Pro Leu Glu Ala Thr Ala Pro Thr Ala Pro Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Asp 
            


<210>  13
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide of tPA

<400>  13
atggatgcta tgaaacgggg cctgtgctgc gtgctgctcc tgtgcggcgc tgtgtttgtg       60

agccctagc                                                               69


<210>  14
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide of tPA

<400>  14

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  15
<211>  6085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GX-188E

<400>  15
acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt       60

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      120

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      180

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      240

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      300

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      360

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt      420

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt      480

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg      540

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctctggcta      600

actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta tagggagacc      660

caagctggct agcgtgagtt tggggaccct tgattgttct ttctttttcg ctattgtaaa      720

attcatgtta tatggagggg gcaaagtttt cagggtgttg tttagaacgg gaagatgtcc      780

cttgtatcac catggaccct catgataatt ttgtttcttt cactttctac tctgttgaca      840

accattgtct cctcttattt tcttttcatt ttctgtaact ttttcgttaa actttagctt      900

gcatttgtaa cgaattttta aattcacttt tgtttatttg tcagattgta agtactttct      960

ctaatcactt ttttttcaag gcaatcaggg tatattatat tgtacttcag cacagtttta     1020

gagaacaatt gttataatta aatgataagg tagaatattt ctgcatataa attctggctg     1080

gcgtggaaat attcttattg gtagaaacaa ctacatcctg gtcatcatcc tgcctttctc     1140

tttatggtta caatgatata cactgtttga gatgaggata aaatactctg agtccaaacc     1200

gggcccctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt     1260

gctggttatt gtgctgtctc atcattttgg caaagaattg taatacgact cactataggg     1320

cgaattgaag cttggtaccg ccaccatgga tgctatgaaa cggggcctgt gctgcgtgct     1380

gctcctgtgc ggcgctgtgt ttgtgagccc tagcatcacc caggactgct ccttccaaca     1440

cagccccatc tcctccgact tcgctgtcaa aatccgtgag ctgtctgact acctgcttca     1500

agattaccca gtcaccgtgg cctccaacct gcaggacgag gagctctgcg ggggcctctg     1560

gcggctggtc ctggcacagc gctggatgga gcggctcaag actgtcgctg ggtccaagat     1620

gcaaggcttg ctggagcgcg tgaacacgga gatacacttt gtcaccaaat gtgcctttca     1680

gccccccccc agctgtcttc gcttcgtcca gaccaacatc tcccgcctcc tgcaggagac     1740

ctccgagcag ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct     1800

ggagctgcag tgtcagcccg actcctcaac cctgccaccc ccatggagtc cccggcccct     1860

ggaggccaca gccccgacag ccccgggcgg cggcagcggc gatgctagca tgcaccagaa     1920

gagaaccgcc atgttccagg accctcagga gagacctagg aagctgcctc acctgtgtac     1980

agagctccag acaaccatcc acgacatcat cctggagtgc gtgtactgta agcagcagct     2040

gctgagaaga gaggtgtacg acttcgcctt cagagacctg tgcatcgtgt acagagacgg     2100

caacccttac gccgtgtgcg ataagtgtct gaagttctat tccaaaatct ccgaatatag     2160

gtacatgcac ggcgacaccc ctaccctgca cgagtacatg ctggacctcc agcctgagac     2220

cacagacctg tactgctacg agcagctgaa cgacagctct gaggaagagg acgagattga     2280

cggacctgct ggccaggccg agcctgacag agcccactac aatatcgtga cattctgttg     2340

caaatgcgac tccacactgg acaagtgcct gaagttctac agcaagatct ctgagtacag     2400

atactactgc tactctgtgt acggcaccac actggagcag cagtacaaca agcctctgtg     2460

cgacctcctg atccgctgca tcaactgcca gaagcctctg tgccctgagg agaagcagag     2520

acacctggac aagaagcagc ggttccacaa catcagaggc agatggaccg gcaggtgcat     2580

gtcctgctgt agatcctcca gaaccagacg ggagacccag ctgcactaca acatcgtgac     2640

cttctgctgc aagtgcgact ctaccctgag actgtgcgtg cagtctaccc acgtggacat     2700

cagaaccctg gaggacctgc tgatgggcac cctgggcatc gtgtgcccta tctgctctca     2760

gaagcctatg gccaggttcg aggaccctac cagaagaccc tacaagctgc ctgacctgtg     2820

caccgagctg aacacctctc tgcaagacat cgagatcacc tgcgtgtact gcaagaccgt     2880

gctggagctg accgaggtgt tcgagttcgc cttcaaggac ctgttcgtgg tgtacagaga     2940

cagcatccct cacgctgcct gccacaagtg catcgacttc tattccagga tcagggagct     3000

gcgctattac tccgactctg tgatgtacgg ccccaaggcc accctccagg acatcgtgct     3060

gcacctggag cctcagaacg agatccccgt ggacctgctg tgccacgagc agctgtctga     3120

ctctgaagag gagaacgacg agatcgacgg cgtgaaccac cagcacctgc ctgccaggag     3180

agctgaaccc cagcggcata ccatgctgtg tatgtgcttc tactctagga tcagagagct     3240

gaggtactac tctgactctg tgtacggcga caccctggag aagctgacca acaccggcct     3300

gtacaacctg ctgatccggt gcctgaggtg ccagaagcct ctgaaccctg ccgagaagct     3360

gagacacctg aacgagaaga gaagattcca caagatcgct ggccactaca gaggccagtg     3420

ccactcttgc tgcaacagag ccagacagga gagactccag cggagaaggg agacccaggt     3480

ggccagaaga gccgagcctc agagacacac catgctgtgc atgtgctgca agtgcgaggc     3540

cagaatcgag ctggtggtgg agagctctgc cgacgacctg agagccttcc agcagctgtt     3600

cctgtctacc ctgagcttcg tgtgcccttg gtgcgcctct cagcagtaat ctagagtcgg     3660

ggcggccggc cgcttcgagc agacatgata agatacattg atgagtttgg acaaaccaca     3720

actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt     3780

gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt     3840

caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt     3900

aaaatcgata aggatctgaa cgatggagcg gagaatgggc ggaactgggc ggagttaggg     3960

gcgggatggg cggagttagg ggcgggacta tggttgctga ctaattgaga tgcatgcttt     4020

gcatacttct gcctgctggg gagcctgggg actttccaca cctggttgct gactaattga     4080

gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca caccctaact     4140

gacacacatt ccacagcgga tccgtcgact tcagaagaac tcgtcaagaa ggcgatagaa     4200

ggcgatgcgc cgcgaatcgg gagcggcgat accgtagagc acgaggaagc ggtcagccca     4260

ttcgccgcca agctcttcag caatatcacg ggtagccaac gctatgtcct gatagcggtc     4320

cgccacaccc agccggccac agtcgatgaa tccagaaaag cggccatttt ccaccatgat     4380

attcggcaag caggcatcgc catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc     4440

cttgagcctg gcgaacagtt cggctggcgc gagcccctga tgctcttcgt ccagatcatc     4500

ctgatcgaca agaccggctt ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg     4560

gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc cgccgcattg catcagccat     4620

gatggatact ttctcggcag gagcaaggtg agatgacagg agatcctgcc ccggcacttc     4680

gcccaatagc agccagtccc ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg     4740

aacgcccgtc gtggccagcc acgatagccg cgctgcctcg tcttgcagtt cattcagggc     4800

accggacagg tcggtcttga caaaaagaac cgggcgcccc tgcgctgaca gccggaacac     4860

ggcggcatca gagcagccga ttgtctgttg tgcccagtca tagccgaata gcctctccac     4920

ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca atcatgcgaa acgatcctca     4980

tcctgtctct tgatcagatc ttgatcccct gcgccatcag atccttggcg gcaagaaagc     5040

catccagttt actttgcagg gcttcccaac cttaccagag ggcgccccag ctggcaattc     5100

cggttcgctt gctgtccata aaaccgccca gtctagctat cgccatgtaa gcccactgca     5160

agctacctgc tttctctttg cgcttgcgtt ttcccttgtc cagatagccc agtagctgac     5220

attcatccgg ggtcagcacc gtttctgcgg actggctttc tacgtgaaaa ggatctaggt     5280

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     5340

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     5400

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     5460

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     5520

tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     5580

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     5640

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     5700

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     5760

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     5820

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcccggta     5880

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     5940

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     6000

cttttgctgg ccttttgctc acatgttcgg gcccaatcga cccgggcgac ggccagtgaa     6060

ttgtaccgat gtacgggcca gatat                                           6085


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-1 helix of E7 protein of HPV16 (position 73-84)

<400>  16

His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met 
1               5                   10          


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-2 sheet of E7 protein of HPV16 (position 64-71)

<400>  17

Thr Leu Arg Leu Cys Val Gln Ser 
1               5               


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-1 sheet of E7 protein of HPV16 (position 48-58)

<400>  18

Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10      


<210>  19
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91670.1 E6 Variant

<400>  19

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  20
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91673.1 E6 Variant

<400>  20

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  21
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91669.1 E6 Variant

<400>  21

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Lys Asn Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  22
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91674.1 E6 Variant

<400>  22

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  23
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91680.1 E6 Variant

<400>  23

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  24
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91681.1

<400>  24

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  25
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91668.1 E6 Variant

<400>  25

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  26
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91658.1 E6 Variant

<400>  26

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  27
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91662.1 E6 Variant

<400>  27

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Glu Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  28
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91667.1 E6 Variant

<400>  28

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Glu Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  29
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91676.1 E6 Variant

<400>  29

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Glu Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  30
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91671.1 E6 Variant

<400>  30

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Glu Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  31
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91656.1 E6 Variant

<400>  31

Met Phe Gln Asp Pro Gln Glu Arg Pro Gly Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  32
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91682.1 E6 Variant

<400>  32

Met Phe Gln Asp Pro Gln Glu Arg Pro Gly Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  33
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91657.1 E6 Variant

<400>  33

Met Phe Gln Asp Pro Gln Glu Arg Pro Gly Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  34
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91660.1 E6 Variant

<400>  34

Met Phe Gln Asp Pro Gln Glu Arg Pro Gly Lys Leu Pro Gln Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  35
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91677.1 E6 Variant

<400>  35

Met Phe Gln Asp Pro Gln Glu Arg Pro Thr Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  36
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91678.1 E6 Variant

<400>  36

Met Phe Gln Asp Pro Gln Glu Arg Pro Thr Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  37
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91672.1 E6 Variant

<400>  37

Met Phe Gln Asp Pro Gln Glu Arg Pro Thr Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  38
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91661.1 E6 Variant

<400>  38

Met Phe Gln Asp Pro Gln Glu Arg Pro Thr Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  39
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91664.1 E6 Variant

<400>  39

Met Phe Gln Asp Pro Gln Glu Arg Pro Ile Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  40
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91675.1 E6 Variant

<400>  40

Met Phe Gln Asp Pro Gln Glu Arg Pro Ile Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  41
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91665.1 E6 Variant

<400>  41

Met Phe Gln Asp Pro Gln Glu Arg Pro Ile Lys Leu Pro Asp Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  42
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91663.1 E6 Variant

<400>  42

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  43
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91659.1 E6 Variant

<400>  43

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  44
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91654.1 E6 Variant

<400>  44

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  45
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91666.1 E6 Variant

<400>  45

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  46
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91679.1 E6 Variant

<400>  46

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  47
<211>  151
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAA91655.1 E6 Variant

<400>  47

Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys 
1               5                   10                  15      


Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
            20                  25                  30          


Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg 
        35                  40                  45              


Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
    50                  55                  60                  


Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys 
65                  70                  75                  80  


Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu 
                85                  90                  95      


Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro 
            100                 105                 110         


Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
        115                 120                 125             


Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg 
    130                 135                 140                 


Thr Arg Arg Glu Thr Gln Leu 
145                 150     


<210>  48
<211>  147
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AHZ96678.1 E6 Variant

<400>  48

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Lys Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln 
145         


<210>  49
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  ABP99784.1 E6 Variant

<400>  49

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Lys Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  50
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  CAB53096.1 E6 Variant

<400>  50

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Lys Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  51
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AGU90327.1 E6 Variant

<400>  51

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Lys Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Gln 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  52
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  ADC35660.1 E6 Variant

<400>  52

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Val Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  53
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AHZ96677.1 E6 Variant

<400>  53

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg His Arg Glu Thr Gln Val 
145                 150                 155             


<210>  54
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  ABP99736.1 E6 Variant

<400>  54

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Gly Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  55
<211>  158
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  ABP99704.1 E6 Variant

<400>  55

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly Arg Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  56
<211>  90
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ABL96587.1 E7 Variant

<400>  56

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Arg Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
                85                  90  


<210>  57
<211>  90
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ABL96591.1 E7 Variant

<400>  57

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Cys Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
                85                  90  


<210>  58
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19726.1 E7 Variant

<400>  58

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Val Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  59
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19722.1 E7 Variant

<400>  59

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Val Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  60
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19752.1 E7 Variant

<400>  60

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Thr Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  61
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19732.1 E7 Variant

<400>  61

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Lys Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Val Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  62
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19762.1 E7 Variant

<400>  62

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Arg Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  63
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19668.1 E7 Variant

<400>  63

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Met Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  64
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19664.1 E7 Variant

<400>  64

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Ser Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  65
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19766.1 E7 Variant

<400>  65

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Asn Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Phe Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  66
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19756.1 E7 Variant

<400>  66

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Lys Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Ile Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  67
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19680.1 E7 Variant

<400>  67

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Thr Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  68
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19772.1 E7 Variant

<400>  68

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Asp Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Asp Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  69
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19696.1 E7 Variant

<400>  69

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Lys Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  70
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19690.1 E7 Variant

<400>  70

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Val Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Gly Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  71
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19712.1 E7 Variant

<400>  71

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Ile Thr Phe Cys Cys Arg Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  72
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AGO04504.1 E7 Variant

<400>  72

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Gly Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Met Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Ala Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  73
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19770.1 E7 Variant

<400>  73

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Tyr Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Gln Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Ala Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  74
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19520.2 E7 Variant

<400>  74

Met His Gly Asp Thr Pro Thr Leu His Lys Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Tyr Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Ser Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  75
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19708.1 E7 Variant

<400>  75

Met His Gly Asp Thr Pro Lys Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Gln Ala Gly Gln Ala Lys Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Gly Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  76
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19674.1 E7 Variant

<400>  76

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Asn Ser 
            20                  25                  30          


Glu Glu Asp His Glu Ile Asp Gly Pro Asp Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  77
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AGO04498.1 E7 Variant

<400>  77

Met His Gly Asp Thr Ser Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Asn Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr Leu Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Met Leu Met Gly Thr Leu Gly Ile Val Ser Pro 
                85                  90          


<210>  78
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AGO04496.1 E7 Variant

<400>  78

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Val Leu Gly Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Val 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Phe Cys Val Gln Ser Thr Arg Leu Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  79
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19684.1 E7 Variant

<400>  79

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu His Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Cys Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Lys Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Ile Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  80
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19678.1 E7 Variant

<400>  80

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Cys Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Thr Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Thr Ile Val Thr Phe Cys Cys Met Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  81
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19698.1 E7 Variant

<400>  81

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn His Ser Ser 
            20                  25                  30          


Glu Gly Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Pro Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Asp Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  82
<211>  92
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFJ19746.1 E7 Variant

<400>  82

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Asp Glu Gln Leu Asn His Ser Ser 
            20                  25                  30          


Glu Gly Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Pro Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
                85                  90          


<210>  83
<211>  93
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAF13395.1 E7 Variant

<400>  83

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Phe Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
                85                  90              


<210>  84
<211>  95
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFU06654.1 E7 Variant

<400>  84

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser 
                85                  90                  95  


<210>  85
<211>  95
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AFU06650.1 E7 Variant

<400>  85

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Phe Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser 
                85                  90                  95  


<210>  86
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAB70738.1 E7 Variant

<400>  86

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Phe Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  87
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ACN22555.1 E7 Variant

<400>  87

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Val Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  88
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ABK32510.1 E7 Variant

<400>  88

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Ser Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  89
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ABC54573.1 E7 Variant

<400>  89

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Ala Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  90
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ACN22554.1 E7 Variant

<400>  90

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Arg Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  91
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ABK32511.1 E7 Variant

<400>  91

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Lys Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Ser Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  92
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ACQ90216.1 E7 Variant

<400>  92

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Arg Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  93
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  ADY75576.1 E7 Variant

<400>  93

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Asn Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Phe Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  94
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAM03025.1 E7 Variant

<400>  94

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Cys Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  95
<211>  98
<212>  PRT
<213>  Human papillomavirus 16


<220>
<221>  MISC_FEATURE
<223>  AAL96634.1 E7 Variant

<400>  95

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Trp Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  96
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  ABP99785.1 E7 Variant

<400>  96

Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  97
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AGU90416.1 E7 Variant

<400>  97

Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  98
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AGU90384.1 E7 Variant

<400>  98

Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Asp Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  99
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  CAB53097.1 E7 Variant

<400>  99

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Lys Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  100
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  P06788.2 E7 Variant

<400>  100

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  101
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  CAB53098.1 E7 Variant

<400>  101

Met His Gly Pro Lys Ala Thr Leu Gln Asn Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Lys Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  102
<211>  105
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  CAB53099.1 E7 Variant

<400>  102

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Gly Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Lys Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  103
<211>  145
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AGM34425.1 E6 Variant

<400>  103

Leu Pro Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu 
1               5                   10                  15      


Ile Thr Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe 
            20                  25                  30          


Glu Phe Ala Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro 
        35                  40                  45              


His Ala Ala Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu 
    50                  55                  60                  


Leu Arg Tyr Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu 
65                  70                  75                  80  


Thr Asn Thr Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln 
                85                  90                  95      


Lys Pro Leu Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg 
            100                 105                 110         


Arg Phe His Lys Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys 
        115                 120                 125             


Cys Asn Arg Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln 
    130                 135                 140                 


Val 
145 


<210>  104
<211>  145
<212>  PRT
<213>  Human papillomavirus 18


<220>
<221>  MISC_FEATURE
<223>  AGM34424.1 E6 Variant

<400>  104

Leu Pro Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu 
1               5                   10                  15      


Ile Thr Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe 
            20                  25                  30          


Glu Phe Ala Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro 
        35                  40                  45              


His Ala Ala Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu 
    50                  55                  60                  


Leu Arg His Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu 
65                  70                  75                  80  


Thr Asn Thr Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln 
                85                  90                  95      


Lys Pro Leu Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg 
            100                 105                 110         


Arg Phe His Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys 
        115                 120                 125             


Cys Asn Arg Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln 
    130                 135                 140                 


Val 
145 


<210>  105
<211>  6085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-1 mutant


<220>
<221>  misc_feature
<222>  (1368)..(1433)
<223>  encodes tPA

<220>
<221>  misc_feature
<222>  (1434)..(1925)
<223>  encodes FLT3L

<220>
<221>  misc_feature
<222>  (1932)..(2186)
<223>  16E6N (H21Q)

<220>
<221>  misc_feature
<222>  (1932)..(2789)
<223>  16E6/E7

<220>
<221>  misc_feature
<222>  (2187)..(2381)
<223>  16E7N

<220>
<221>  misc_feature
<222>  (2382)..(2645)
<223>  16E6C (Y85H, V90L)

<220>
<221>  misc_feature
<222>  (2646)..(2789)
<223>  16E7C

<220>
<221>  misc_feature
<222>  (2790)..(3671)
<223>  18E6/E7

<400>  105
taccgatgta cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta       60

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac      120

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac      180

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      240

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      300

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga      360

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt      420

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca      480

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg      540

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta      600

tataagcaga gctctctggc taactagaga acccactgct tactggctta tcgaaattaa      660

tacgactcac tatagggaga cccaagctgg ctagcgtgag tttggggacc cttgattgtt      720

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      780

tgtttagaac gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      840

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      900

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      960

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat     1020

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1080

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacatcc     1140

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1200

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctttt     1260

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     1320

tgtaatacga ctcactatag ggcgaattga agcttggtac cgccaccatg gatgctatga     1380

aacggggcct gtgctgcgtg ctgctcctgt gcggcgctgt gtttgtgagc cctagcatca     1440

cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc aaaatccgtg     1500

agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac ctgcaggacg     1560

aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg gagcggctca     1620

agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg gagatacact     1680

ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc cagaccaaca     1740

tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc tggatcactc     1800

gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca accctgccac     1860

ccccatggag tccccggccc ctggaggcca cagccccgac agccccgggc ggcggcagcg     1920

gcgatgctag catgcaccag aagagaaccg ccatgttcca ggaccctcag gagagaccta     1980

ggaagctgcc tcagctgtgt acagagctcc agacaaccat ccacgacatc atcctggagt     2040

gcgtgtactg taagcagcag ctgctgagaa gagaggtgta cgacttcgcc ttcagagacc     2100

tgtgcatcgt gtacagagac ggcaaccctt acgccgtgtg cgataagtgt ctgaagttct     2160

attccaaaat ctccgaatat aggtacatgc acggcgacac ccctaccctg cacgagtaca     2220

tgctggacct ccagcctgag accacagacc tgtactgcta cgagcagctg aacgacagct     2280

ctgaggaaga ggacgagatt gacggacctg ctggccaggc cgagcctgac agagcccact     2340

acaatatcgt gacattctgt tgcaaatgcg actccacact ggacaagtgc ctgaagttct     2400

acagcaagat ctctgagtac agacactact gctactctct gtacggcacc acactggagc     2460

agcagtacaa caagcctctg tgcgacctcc tgatccgctg catcaactgc cagaagcctc     2520

tgtgccctga ggagaagcag agacacctgg acaagaagca gcggttccac aacatcagag     2580

gcagatggac cggcaggtgc atgtcctgct gtagatcctc cagaaccaga cgggagaccc     2640

agctgcacta caacatcgtg accttctgct gcaagtgcga ctctaccctg agactgtgcg     2700

tgcagtctac ccacgtggac atcagaaccc tggaggacct gctgatgggc accctgggca     2760

tcgtgtgccc tatctgctct cagaagccta tggccaggtt cgaggaccct accagaagac     2820

cctacaagct gcctgacctg tgcaccgagc tgaacacctc tctgcaagac atcgagatca     2880

cctgcgtgta ctgcaagacc gtgctggagc tgaccgaggt gttcgagttc gccttcaagg     2940

acctgttcgt ggtgtacaga gacagcatcc ctcacgctgc ctgccacaag tgcatcgact     3000

tctattccag gatcagggag ctgcgctatt actccgactc tgtgatgtac ggccccaagg     3060

ccaccctcca ggacatcgtg ctgcacctgg agcctcagaa cgagatcccc gtggacctgc     3120

tgtgccacga gcagctgtct gactctgaag aggagaacga cgagatcgac ggcgtgaacc     3180

accagcacct gcctgccagg agagctgaac cccagcggca taccatgctg tgtatgtgct     3240

tctactctag gatcagagag ctgaggtact actctgactc tgtgtacggc gacaccctgg     3300

agaagctgac caacaccggc ctgtacaacc tgctgatccg gtgcctgagg tgccagaagc     3360

ctctgaaccc tgccgagaag ctgagacacc tgaacgagaa gagaagattc cacaagatcg     3420

ctggccacta cagaggccag tgccactctt gctgcaacag agccagacag gagagactcc     3480

agcggagaag ggagacccag gtggccagaa gagccgagcc tcagagacac accatgctgt     3540

gcatgtgctg caagtgcgag gccagaatcg agctggtggt ggagagctct gccgacgacc     3600

tgagagcctt ccagcagctg ttcctgtcta ccctgagctt cgtgtgccct tggtgcgcct     3660

ctcagcagta atctagagtc ggggcggccg gccgcttcga gcagacatga taagatacat     3720

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     3780

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     3840

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa     3900

gtaaaacctc tacaaatgtg gtaaaatcga taaggatctg aacgatggag cggagaatgg     3960

gcggaactgg gcggagttag gggcgggatg ggcggagtta ggggcgggac tatggttgct     4020

gactaattga gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca     4080

cacctggttg ctgactaatt gagatgcatg ctttgcatac ttctgcctgc tggggagcct     4140

ggggactttc cacaccctaa ctgacacaca ttccacagcg gatccgtcga cttcagaaga     4200

actcgtcaag aaggcgatag aaggcgatgc gccgcgaatc gggagcggcg ataccgtaga     4260

gcacgaggaa gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca     4320

acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa     4380

agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat     4440

cctcgccgtc gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct     4500

gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc     4560

gctcgatgcg atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca     4620

gccgccgcat tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca     4680

ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa     4740

cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct     4800

cgtcttgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc     4860

cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt     4920

catagccgaa tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt     4980

caatcatgcg aaacgatcct catcctgtct cttgatcaga tcttgatccc ctgcgccatc     5040

agatccttgg cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag     5100

agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct     5160

atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg     5220

tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc ggactggctt     5280

tctacgtgaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt     5340

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt     5400

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag     5460

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca     5520

gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca     5580

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg     5640

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg     5700

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct     5760

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     5820

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     5880

ttccaggggg aaacgcccgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     5940

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     6000

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc gggcccaatc     6060

gacccgggcg acggccagtg aattg                                           6085


<210>  106
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-1

<400>  106

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ile Thr Gln Asp Cys Ser Phe Gln His 
            20                  25                  30          


Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
        35                  40                  45              


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
65                  70                  75                  80  


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 
                85                  90                  95      


Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 
            100                 105                 110         


Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 
        115                 120                 125             


Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 
    130                 135                 140                 


Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 
145                 150                 155                 160 


Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala 
                165                 170                 175     


Pro Thr Ala Pro Gly Gly Gly Ser Gly Asp Ala Ser Met His Gln Lys 
            180                 185                 190         


Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro 
        195                 200                 205             


Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu 
    210                 215                 220                 


Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe 
225                 230                 235                 240 


Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
                245                 250                 255     


Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
            260                 265                 270         


Tyr Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu 
        275                 280                 285             


Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser 
    290                 295                 300                 


Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro 
305                 310                 315                 320 


Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser 
                325                 330                 335     


Thr Leu Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
            340                 345                 350         


His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn 
        355                 360                 365             


Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro 
    370                 375                 380                 


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe 
385                 390                 395                 400 


His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg 
                405                 410                 415     


Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu His Tyr Asn Ile Val Thr 
            420                 425                 430         


Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr 
        435                 440                 445             


His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly 
    450                 455                 460                 


Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Met Ala Arg Phe Glu Asp 
465                 470                 475                 480 


Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr Glu Leu Asn 
                485                 490                 495     


Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys Lys Thr Val 
            500                 505                 510         


Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys Asp Leu Phe Val 
        515                 520                 525             


Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His Lys Cys Ile Asp 
    530                 535                 540                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Met 
545                 550                 555                 560 


Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro 
                565                 570                 575     


Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp 
            580                 585                 590         


Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu 
        595                 600                 605             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys 
    610                 615                 620                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Tyr 
625                 630                 635                 640 


Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu 
                645                 650                 655     


Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu Lys Leu 
            660                 665                 670         


Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile Ala Gly His Tyr 
        675                 680                 685             


Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu 
    690                 695                 700                 


Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala Glu Pro Gln Arg 
705                 710                 715                 720 


His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu 
                725                 730                 735     


Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe 
            740                 745                 750         


Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln  
        755                 760                 765             


<210>  107
<211>  6085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2 mutant


<220>
<221>  misc_feature
<222>  (1368)..(1433)
<223>  encodes tPA

<220>
<221>  misc_feature
<222>  (1434)..(1925)
<223>  encodes FLT3L

<220>
<221>  misc_feature
<222>  (1932)..(2186)
<223>  16E6N

<220>
<221>  misc_feature
<222>  (1932)..(2789)
<223>  16E6/E7

<220>
<221>  misc_feature
<222>  (2187)..(2381)
<223>  16E7N (M12K, N29S)

<220>
<221>  misc_feature
<222>  (2382)..(2645)
<223>  16E6C

<220>
<221>  misc_feature
<222>  (2646)..(2789)
<223>  16E7C (R77S, G85S)

<220>
<221>  misc_feature
<222>  (2790)..(3671)
<223>  18E6/E7

<400>  107
taccgatgta cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta       60

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac      120

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac      180

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      240

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      300

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga      360

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt      420

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca      480

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg      540

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta      600

tataagcaga gctctctggc taactagaga acccactgct tactggctta tcgaaattaa      660

tacgactcac tatagggaga cccaagctgg ctagcgtgag tttggggacc cttgattgtt      720

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      780

tgtttagaac gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      840

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      900

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      960

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat     1020

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1080

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacatcc     1140

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1200

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctttt     1260

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     1320

tgtaatacga ctcactatag ggcgaattga agcttggtac cgccaccatg gatgctatga     1380

aacggggcct gtgctgcgtg ctgctcctgt gcggcgctgt gtttgtgagc cctagcatca     1440

cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc aaaatccgtg     1500

agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac ctgcaggacg     1560

aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg gagcggctca     1620

agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg gagatacact     1680

ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc cagaccaaca     1740

tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc tggatcactc     1800

gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca accctgccac     1860

ccccatggag tccccggccc ctggaggcca cagccccgac agccccgggc ggcggcagcg     1920

gcgatgctag catgcaccag aagagaaccg ccatgttcca ggaccctcag gagagaccta     1980

ggaagctgcc tcacctgtgt acagagctcc agacaaccat ccacgacatc atcctggagt     2040

gcgtgtactg taagcagcag ctgctgagaa gagaggtgta cgacttcgcc ttcagagacc     2100

tgtgcatcgt gtacagagac ggcaaccctt acgccgtgtg cgataagtgt ctgaagttct     2160

attccaaaat ctccgaatat aggtacatgc acggcgacac ccctaccctg cacgagtaca     2220

agctggacct ccagcctgag accacagacc tgtactgcta cgagcagctg tctgacagct     2280

ctgaggaaga ggacgagatt gacggacctg ctggccaggc cgagcctgac agagcccact     2340

acaatatcgt gacattctgt tgcaaatgcg actccacact ggacaagtgc ctgaagttct     2400

acagcaagat ctctgagtac agatactact gctactctgt gtacggcacc acactggagc     2460

agcagtacaa caagcctctg tgcgacctcc tgatccgctg catcaactgc cagaagcctc     2520

tgtgccctga ggagaagcag agacacctgg acaagaagca gcggttccac aacatcagag     2580

gcagatggac cggcaggtgc atgtcctgct gtagatcctc cagaaccaga cgggagaccc     2640

agctgcacta caacatcgtg accttctgct gcaagtgcga ctctaccctg agactgtgcg     2700

tgcagtctac ccacgtggac atcctcaccc tggaggacct gctgatgctc accctgggca     2760

tcgtgtgccc tatctgctct cagaagccta tggccaggtt cgaggaccct accagaagac     2820

cctacaagct gcctgacctg tgcaccgagc tgaacacctc tctgcaagac atcgagatca     2880

cctgcgtgta ctgcaagacc gtgctggagc tgaccgaggt gttcgagttc gccttcaagg     2940

acctgttcgt ggtgtacaga gacagcatcc ctcacgctgc ctgccacaag tgcatcgact     3000

tctattccag gatcagggag ctgcgctatt actccgactc tgtgatgtac ggccccaagg     3060

ccaccctcca ggacatcgtg ctgcacctgg agcctcagaa cgagatcccc gtggacctgc     3120

tgtgccacga gcagctgtct gactctgaag aggagaacga cgagatcgac ggcgtgaacc     3180

accagcacct gcctgccagg agagctgaac cccagcggca taccatgctg tgtatgtgct     3240

tctactctag gatcagagag ctgaggtact actctgactc tgtgtacggc gacaccctgg     3300

agaagctgac caacaccggc ctgtacaacc tgctgatccg gtgcctgagg tgccagaagc     3360

ctctgaaccc tgccgagaag ctgagacacc tgaacgagaa gagaagattc cacaagatcg     3420

ctggccacta cagaggccag tgccactctt gctgcaacag agccagacag gagagactcc     3480

agcggagaag ggagacccag gtggccagaa gagccgagcc tcagagacac accatgctgt     3540

gcatgtgctg caagtgcgag gccagaatcg agctggtggt ggagagctct gccgacgacc     3600

tgagagcctt ccagcagctg ttcctgtcta ccctgagctt cgtgtgccct tggtgcgcct     3660

ctcagcagta atctagagtc ggggcggccg gccgcttcga gcagacatga taagatacat     3720

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     3780

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     3840

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa     3900

gtaaaacctc tacaaatgtg gtaaaatcga taaggatctg aacgatggag cggagaatgg     3960

gcggaactgg gcggagttag gggcgggatg ggcggagtta ggggcgggac tatggttgct     4020

gactaattga gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca     4080

cacctggttg ctgactaatt gagatgcatg ctttgcatac ttctgcctgc tggggagcct     4140

ggggactttc cacaccctaa ctgacacaca ttccacagcg gatccgtcga cttcagaaga     4200

actcgtcaag aaggcgatag aaggcgatgc gccgcgaatc gggagcggcg ataccgtaga     4260

gcacgaggaa gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca     4320

acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa     4380

agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat     4440

cctcgccgtc gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct     4500

gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc     4560

gctcgatgcg atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca     4620

gccgccgcat tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca     4680

ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa     4740

cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct     4800

cgtcttgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc     4860

cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt     4920

catagccgaa tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt     4980

caatcatgcg aaacgatcct catcctgtct cttgatcaga tcttgatccc ctgcgccatc     5040

agatccttgg cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag     5100

agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct     5160

atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg     5220

tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc ggactggctt     5280

tctacgtgaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt     5340

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt     5400

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag     5460

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca     5520

gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca     5580

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg     5640

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg     5700

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct     5760

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     5820

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     5880

ttccaggggg aaacgcccgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     5940

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     6000

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc gggcccaatc     6060

gacccgggcg acggccagtg aattg                                           6085


<210>  108
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2

<400>  108

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ile Thr Gln Asp Cys Ser Phe Gln His 
            20                  25                  30          


Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
        35                  40                  45              


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
65                  70                  75                  80  


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 
                85                  90                  95      


Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 
            100                 105                 110         


Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 
        115                 120                 125             


Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 
    130                 135                 140                 


Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 
145                 150                 155                 160 


Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala 
                165                 170                 175     


Pro Thr Ala Pro Gly Gly Gly Ser Gly Asp Ala Ser Met His Gln Lys 
            180                 185                 190         


Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro 
        195                 200                 205             


His Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu 
    210                 215                 220                 


Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe 
225                 230                 235                 240 


Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
                245                 250                 255     


Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
            260                 265                 270         


Tyr Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Lys Leu Asp Leu 
        275                 280                 285             


Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser 
    290                 295                 300                 


Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro 
305                 310                 315                 320 


Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser 
                325                 330                 335     


Thr Leu Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
            340                 345                 350         


Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn 
        355                 360                 365             


Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro 
    370                 375                 380                 


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe 
385                 390                 395                 400 


His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg 
                405                 410                 415     


Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu His Tyr Asn Ile Val Thr 
            420                 425                 430         


Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr 
        435                 440                 445             


His Val Asp Ile Leu Thr Leu Glu Asp Leu Leu Met Leu Thr Leu Gly 
    450                 455                 460                 


Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Met Ala Arg Phe Glu Asp 
465                 470                 475                 480 


Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr Glu Leu Asn 
                485                 490                 495     


Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys Lys Thr Val 
            500                 505                 510         


Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys Asp Leu Phe Val 
        515                 520                 525             


Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His Lys Cys Ile Asp 
    530                 535                 540                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Met 
545                 550                 555                 560 


Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro 
                565                 570                 575     


Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp 
            580                 585                 590         


Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu 
        595                 600                 605             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys 
    610                 615                 620                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Tyr 
625                 630                 635                 640 


Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu 
                645                 650                 655     


Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu Lys Leu 
            660                 665                 670         


Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile Ala Gly His Tyr 
        675                 680                 685             


Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu 
    690                 695                 700                 


Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala Glu Pro Gln Arg 
705                 710                 715                 720 


His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu 
                725                 730                 735     


Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe 
            740                 745                 750         


Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln 
        755                 760                 765         


<210>  109
<211>  5995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D-1 (overlapping-1)


<220>
<221>  misc_feature
<222>  (1368)..(1433)
<223>  encodes tPA

<220>
<221>  misc_feature
<222>  (1434)..(1925)
<223>  encodes FLT3L

<220>
<221>  misc_feature
<222>  (1932)..(2165)
<223>  16E6N (1-78aa)

<220>
<221>  misc_feature
<222>  (2166)..(2339)
<223>  16E7N (1-58aa)

<220>
<221>  misc_feature
<222>  (2340)..(2579)
<223>  16E6C (79-158aa)

<220>
<221>  misc_feature
<222>  (2580)..(2699)
<223>  16E7C (59-98aa)

<220>
<221>  misc_feature
<222>  (2700)..(3581)
<223>  18E6/E7

<400>  109
taccgatgta cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta       60

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac      120

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac      180

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      240

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      300

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga      360

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt      420

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca      480

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg      540

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta      600

tataagcaga gctctctggc taactagaga acccactgct tactggctta tcgaaattaa      660

tacgactcac tatagggaga cccaagctgg ctagcgtgag tttggggacc cttgattgtt      720

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      780

tgtttagaac gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      840

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      900

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      960

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat     1020

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1080

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacatcc     1140

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1200

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctttt     1260

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     1320

tgtaatacga ctcactatag ggcgaattga agcttggtac cgccaccatg gatgctatga     1380

aacggggcct gtgctgcgtg ctgctcctgt gcggcgctgt gtttgtgagc cctagcatca     1440

cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc aaaatccgtg     1500

agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac ctgcaggacg     1560

aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg gagcggctca     1620

agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg gagatacact     1680

ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc cagaccaaca     1740

tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc tggatcactc     1800

gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca accctgccac     1860

ccccatggag tccccggccc ctggaggcca cagccccgac agccccgggc ggcggcagcg     1920

gcgatgctag catgcaccag aagagaaccg ccatgttcca ggaccctcag gagagaccta     1980

ggaagctgcc tcacctgtgt acagagctcc agacaaccat ccacgacatc atcctggagt     2040

gcgtgtactg taagcagcag ctgctgagaa gagaggtgta cgacttcgcc ttcagagacc     2100

tgtgcatcgt gtacagagac ggcaaccctt acgccgtgtg cgataagtgt ctgaagttct     2160

attccatgca cggcgacacc cctaccctgc acgagtacat gctggacctc cagcctgaga     2220

ccacagacct gtactgctac gagcagctga acgacagctc tgaggaagag gacgagattg     2280

acggacctgc tggccaggcc gagcctgaca gagcccacta caatatcgtg acattctgta     2340

agatctctga gtacagatac tactgctact ctgtgtacgg caccacactg gagcagcagt     2400

acaacaagcc tctgtgcgac ctcctgatcc gctgcatcaa ctgccagaag cctctgtgcc     2460

ctgaggagaa gcagagacac ctggacaaga agcagcggtt ccacaacatc agaggcagat     2520

ggaccggcag gtgcatgtcc tgctgtagat cctccagaac cagacgggag acccagctgt     2580

gcaagtgcga ctctaccctg agactgtgcg tgcagtctac ccacgtggac atcagaaccc     2640

tggaggacct gctgatgggc accctgggca tcgtgtgccc tatctgctct cagaagccta     2700

tggccaggtt cgaggaccct accagaagac cctacaagct gcctgacctg tgcaccgagc     2760

tgaacacctc tctgcaagac atcgagatca cctgcgtgta ctgcaagacc gtgctggagc     2820

tgaccgaggt gttcgagttc gccttcaagg acctgttcgt ggtgtacaga gacagcatcc     2880

ctcacgctgc ctgccacaag tgcatcgact tctattccag gatcagggag ctgcgctatt     2940

actccgactc tgtgatgtac ggccccaagg ccaccctcca ggacatcgtg ctgcacctgg     3000

agcctcagaa cgagatcccc gtggacctgc tgtgccacga gcagctgtct gactctgaag     3060

aggagaacga cgagatcgac ggcgtgaacc accagcacct gcctgccagg agagctgaac     3120

cccagcggca taccatgctg tgtatgtgct tctactctag gatcagagag ctgaggtact     3180

actctgactc tgtgtacggc gacaccctgg agaagctgac caacaccggc ctgtacaacc     3240

tgctgatccg gtgcctgagg tgccagaagc ctctgaaccc tgccgagaag ctgagacacc     3300

tgaacgagaa gagaagattc cacaagatcg ctggccacta cagaggccag tgccactctt     3360

gctgcaacag agccagacag gagagactcc agcggagaag ggagacccag gtggccagaa     3420

gagccgagcc tcagagacac accatgctgt gcatgtgctg caagtgcgag gccagaatcg     3480

agctggtggt ggagagctct gccgacgacc tgagagcctt ccagcagctg ttcctgtcta     3540

ccctgagctt cgtgtgccct tggtgcgcct ctcagcagta atctagagtc ggggcggccg     3600

gccgcttcga gcagacatga taagatacat tgatgagttt ggacaaacca caactagaat     3660

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     3720

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     3780

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtaaaatcga     3840

taaggatctg aacgatggag cggagaatgg gcggaactgg gcggagttag gggcgggatg     3900

ggcggagtta ggggcgggac tatggttgct gactaattga gatgcatgct ttgcatactt     3960

ctgcctgctg gggagcctgg ggactttcca cacctggttg ctgactaatt gagatgcatg     4020

ctttgcatac ttctgcctgc tggggagcct ggggactttc cacaccctaa ctgacacaca     4080

ttccacagcg gatccgtcga cttcagaaga actcgtcaag aaggcgatag aaggcgatgc     4140

gccgcgaatc gggagcggcg ataccgtaga gcacgaggaa gcggtcagcc cattcgccgc     4200

caagctcttc agcaatatca cgggtagcca acgctatgtc ctgatagcgg tccgccacac     4260

ccagccggcc acagtcgatg aatccagaaa agcggccatt ttccaccatg atattcggca     4320

agcaggcatc gccatgggtc acgacgagat cctcgccgtc gggcatgctc gccttgagcc     4380

tggcgaacag ttcggctggc gcgagcccct gatgctcttc gtccagatca tcctgatcga     4440

caagaccggc ttccatccga gtacgtgctc gctcgatgcg atgtttcgct tggtggtcga     4500

atgggcaggt agccggatca agcgtatgca gccgccgcat tgcatcagcc atgatggata     4560

ctttctcggc aggagcaagg tgagatgaca ggagatcctg ccccggcact tcgcccaata     4620

gcagccagtc ccttcccgct tcagtgacaa cgtcgagcac agctgcgcaa ggaacgcccg     4680

tcgtggccag ccacgatagc cgcgctgcct cgtcttgcag ttcattcagg gcaccggaca     4740

ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga cagccggaac acggcggcat     4800

cagagcagcc gattgtctgt tgtgcccagt catagccgaa tagcctctcc acccaagcgg     4860

ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcg aaacgatcct catcctgtct     4920

cttgatcaga tcttgatccc ctgcgccatc agatccttgg cggcaagaaa gccatccagt     4980

ttactttgca gggcttccca accttaccag agggcgcccc agctggcaat tccggttcgc     5040

ttgctgtcca taaaaccgcc cagtctagct atcgccatgt aagcccactg caagctacct     5100

gctttctctt tgcgcttgcg ttttcccttg tccagatagc ccagtagctg acattcatcc     5160

ggggtcagca ccgtttctgc ggactggctt tctacgtgaa aaggatctag gtgaagatcc     5220

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag     5280

accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct     5340

gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac     5400

caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc     5460

tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg     5520

ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt     5580

tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt     5640

gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc     5700

tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca     5760

gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcccgg tatctttata     5820

gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg     5880

ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct     5940

ggccttttgc tcacatgttc gggcccaatc gacccgggcg acggccagtg aattg          5995


<210>  110
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-1

<400>  110

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ile Thr Gln Asp Cys Ser Phe Gln His 
            20                  25                  30          


Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
        35                  40                  45              


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
65                  70                  75                  80  


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 
                85                  90                  95      


Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 
            100                 105                 110         


Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 
        115                 120                 125             


Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 
    130                 135                 140                 


Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 
145                 150                 155                 160 


Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala 
                165                 170                 175     


Pro Thr Ala Pro Gly Gly Gly Ser Gly Asp Ala Ser Met His Gln Lys 
            180                 185                 190         


Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro 
        195                 200                 205             


His Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu 
    210                 215                 220                 


Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe 
225                 230                 235                 240 


Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
                245                 250                 255     


Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Met His Gly Asp Thr Pro 
            260                 265                 270         


Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu 
        275                 280                 285             


Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile 
    290                 295                 300                 


Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
305                 310                 315                 320 


Val Thr Phe Cys Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Val 
                325                 330                 335     


Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu 
            340                 345                 350         


Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys 
        355                 360                 365             


Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg 
    370                 375                 380                 


Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg 
385                 390                 395                 400 


Glu Thr Gln Leu Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln 
                405                 410                 415     


Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
            420                 425                 430         


Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Met Ala Arg Phe 
        435                 440                 445             


Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr Glu 
    450                 455                 460                 


Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys Lys 
465                 470                 475                 480 


Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys Asp Leu 
                485                 490                 495     


Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His Lys Cys 
            500                 505                 510         


Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser 
        515                 520                 525             


Val Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu 
    530                 535                 540                 


Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu 
545                 550                 555                 560 


Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln 
                565                 570                 575     


His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys 
            580                 585                 590         


Met Cys Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser 
        595                 600                 605             


Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn 
    610                 615                 620                 


Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu 
625                 630                 635                 640 


Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile Ala Gly 
                645                 650                 655     


His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu 
            660                 665                 670         


Arg Leu Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala Glu Pro 
        675                 680                 685             


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
    690                 695                 700                 


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
705                 710                 715                 720 


Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
                725                 730                 735     


Gln 
    


<210>  111
<211>  6379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D-2 (overlapping-2)


<220>
<221>  misc_feature
<222>  (1368)..(1433)
<223>  encodes tPA

<220>
<221>  misc_feature
<222>  (1434)..(1925)
<223>  encodes FLT3L

<220>
<221>  misc_feature
<222>  (1932)..(2321)
<223>  16E6N (1-130aa)

<220>
<221>  misc_feature
<222>  (1932)..(3083)
<223>  16E6/E7

<220>
<221>  misc_feature
<222>  (2322)..(2576)
<223>  16E7N (1-85aa)

<220>
<221>  misc_feature
<222>  (2577)..(2918)
<223>  16E6C (45-158aa)

<220>
<221>  misc_feature
<222>  (2919)..(3083)
<223>  16E7C (44-98aa)

<220>
<221>  misc_feature
<222>  (3084)..(3965)
<223>  18E6/E7

<400>  111
taccgatgta cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta       60

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac      120

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac      180

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      240

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      300

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga      360

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt      420

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca      480

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg      540

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta      600

tataagcaga gctctctggc taactagaga acccactgct tactggctta tcgaaattaa      660

tacgactcac tatagggaga cccaagctgg ctagcgtgag tttggggacc cttgattgtt      720

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      780

tgtttagaac gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      840

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      900

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      960

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat     1020

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1080

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacatcc     1140

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1200

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctttt     1260

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     1320

tgtaatacga ctcactatag ggcgaattga agcttggtac cgccaccatg gatgctatga     1380

aacggggcct gtgctgcgtg ctgctcctgt gcggcgctgt gtttgtgagc cctagcatca     1440

cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc aaaatccgtg     1500

agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac ctgcaggacg     1560

aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg gagcggctca     1620

agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg gagatacact     1680

ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc cagaccaaca     1740

tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc tggatcactc     1800

gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca accctgccac     1860

ccccatggag tccccggccc ctggaggcca cagccccgac agccccgggc ggcggcagcg     1920

gcgatgctag catgcaccag aagagaaccg ccatgttcca ggaccctcag gagagaccta     1980

ggaagctgcc tcacctgtgt acagagctcc agacaaccat ccacgacatc atcctggagt     2040

gcgtgtactg taagcagcag ctgctgagaa gagaggtgta cgacttcgcc ttcagagacc     2100

tgtgcatcgt gtacagagac ggcaaccctt acgccgtgtg cgataagtgt ctgaagttct     2160

attccaagat ctctgagtac agatactact gctactctgt gtacggcacc acactggagc     2220

agcagtacaa caagcctctg tgcgacctcc tgatccgctg catcaactgc cagaagcctc     2280

tgtgccctga ggagaagcag agacacctgg acaagaagca gatgcacggc gacaccccta     2340

ccctgcacga gtacatgctg gacctccagc ctgagaccac agacctgtac tgctacgagc     2400

agctgaacga cagctctgag gaagaggacg agattgacgg acctgctggc caggccgagc     2460

ctgacagagc ccactacaat atcgtgacat tctgttgcaa gtgcgactct accctgagac     2520

tgtgcgtgca gtctacccac gtggacatca gaaccctgga ggacctgctg atgggcctga     2580

gaagagaggt gtacgacttc gccttcagag acctgtgcat cgtgtacaga gacggcaacc     2640

cttacgccgt gtgcgataag tgtctgaagt tctattccaa gatctctgag tacagatact     2700

actgctactc tgtgtacggc accacactgg agcagcagta caacaagcct ctgtgcgacc     2760

tcctgatccg ctgcatcaac tgccagaagc ctctgtgccc tgaggagaag cagagacacc     2820

tggacaagaa gcagcggttc cacaacatca gaggcagatg gaccggcagg tgcatgtcct     2880

gctgtagatc ctccagaacc agacgggaga cccagctgca ggccgagcct gacagagccc     2940

actacaatat cgtgacattc tgttgcaagt gcgactctac cctgagactg tgcgtgcagt     3000

ctacccacgt ggacatcaga accctggagg acctgctgat gggcaccctg ggcatcgtgt     3060

gccctatctg ctctcagaag cctatggcca ggttcgagga ccctaccaga agaccctaca     3120

agctgcctga cctgtgcacc gagctgaaca cctctctgca agacatcgag atcacctgcg     3180

tgtactgcaa gaccgtgctg gagctgaccg aggtgttcga gttcgccttc aaggacctgt     3240

tcgtggtgta cagagacagc atccctcacg ctgcctgcca caagtgcatc gacttctatt     3300

ccaggatcag ggagctgcgc tattactccg actctgtgat gtacggcccc aaggccaccc     3360

tccaggacat cgtgctgcac ctggagcctc agaacgagat ccccgtggac ctgctgtgcc     3420

acgagcagct gtctgactct gaagaggaga acgacgagat cgacggcgtg aaccaccagc     3480

acctgcctgc caggagagct gaaccccagc ggcataccat gctgtgtatg tgcttctact     3540

ctaggatcag agagctgagg tactactctg actctgtgta cggcgacacc ctggagaagc     3600

tgaccaacac cggcctgtac aacctgctga tccggtgcct gaggtgccag aagcctctga     3660

accctgccga gaagctgaga cacctgaacg agaagagaag attccacaag atcgctggcc     3720

actacagagg ccagtgccac tcttgctgca acagagccag acaggagaga ctccagcgga     3780

gaagggagac ccaggtggcc agaagagccg agcctcagag acacaccatg ctgtgcatgt     3840

gctgcaagtg cgaggccaga atcgagctgg tggtggagag ctctgccgac gacctgagag     3900

ccttccagca gctgttcctg tctaccctga gcttcgtgtg cccttggtgc gcctctcagc     3960

agtaatctag agtcggggcg gccggccgct tcgagcagac atgataagat acattgatga     4020

gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga     4080

tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg     4140

cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa     4200

cctctacaaa tgtggtaaaa tcgataagga tctgaacgat ggagcggaga atgggcggaa     4260

ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt tgctgactaa     4320

ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt tccacacctg     4380

gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga gcctggggac     4440

tttccacacc ctaactgaca cacattccac agcggatccg tcgacttcag aagaactcgt     4500

caagaaggcg atagaaggcg atgcgccgcg aatcgggagc ggcgataccg tagagcacga     4560

ggaagcggtc agcccattcg ccgccaagct cttcagcaat atcacgggta gccaacgcta     4620

tgtcctgata gcggtccgcc acacccagcc ggccacagtc gatgaatcca gaaaagcggc     4680

cattttccac catgatattc ggcaagcagg catcgccatg ggtcacgacg agatcctcgc     4740

cgtcgggcat gctcgccttg agcctggcga acagttcggc tggcgcgagc ccctgatgct     4800

cttcgtccag atcatcctga tcgacaagac cggcttccat ccgagtacgt gctcgctcga     4860

tgcgatgttt cgcttggtgg tcgaatgggc aggtagccgg atcaagcgta tgcagccgcc     4920

gcattgcatc agccatgatg gatactttct cggcaggagc aaggtgagat gacaggagat     4980

cctgccccgg cacttcgccc aatagcagcc agtcccttcc cgcttcagtg acaacgtcga     5040

gcacagctgc gcaaggaacg cccgtcgtgg ccagccacga tagccgcgct gcctcgtctt     5100

gcagttcatt cagggcaccg gacaggtcgg tcttgacaaa aagaaccggg cgcccctgcg     5160

ctgacagccg gaacacggcg gcatcagagc agccgattgt ctgttgtgcc cagtcatagc     5220

cgaatagcct ctccacccaa gcggccggag aacctgcgtg caatccatct tgttcaatca     5280

tgcgaaacga tcctcatcct gtctcttgat cagatcttga tcccctgcgc catcagatcc     5340

ttggcggcaa gaaagccatc cagtttactt tgcagggctt cccaacctta ccagagggcg     5400

ccccagctgg caattccggt tcgcttgctg tccataaaac cgcccagtct agctatcgcc     5460

atgtaagccc actgcaagct acctgctttc tctttgcgct tgcgttttcc cttgtccaga     5520

tagcccagta gctgacattc atccggggtc agcaccgttt ctgcggactg gctttctacg     5580

tgaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg     5640

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc     5700

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg     5760

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag     5820

cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact     5880

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg     5940

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc     6000

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg     6060

aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg     6120

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag     6180

ggggaaacgc ccggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc     6240

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct     6300

ttttacggtt cctggccttt tgctggcctt ttgctcacat gttcgggccc aatcgacccg     6360

ggcgacggcc agtgaattg                                                  6379


<210>  112
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-2

<400>  112

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ile Thr Gln Asp Cys Ser Phe Gln His 
            20                  25                  30          


Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
        35                  40                  45              


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
65                  70                  75                  80  


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 
                85                  90                  95      


Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 
            100                 105                 110         


Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 
        115                 120                 125             


Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 
    130                 135                 140                 


Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 
145                 150                 155                 160 


Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala 
                165                 170                 175     


Pro Thr Ala Pro Gly Gly Gly Ser Gly Asp Ala Ser Met His Gln Lys 
            180                 185                 190         


Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro 
        195                 200                 205             


His Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu 
    210                 215                 220                 


Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe 
225                 230                 235                 240 


Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
                245                 250                 255     


Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
            260                 265                 270         


Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn 
        275                 280                 285             


Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro 
    290                 295                 300                 


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Met His 
305                 310                 315                 320 


Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu 
                325                 330                 335     


Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu 
            340                 345                 350         


Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
        355                 360                 365             


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
    370                 375                 380                 


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
385                 390                 395                 400 


Leu Met Gly Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu 
                405                 410                 415     


Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys 
            420                 425                 430         


Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser 
        435                 440                 445             


Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp 
    450                 455                 460                 


Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu 
465                 470                 475                 480 


Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly 
                485                 490                 495     


Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg 
            500                 505                 510         


Arg Glu Thr Gln Leu Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
        515                 520                 525             


Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln 
    530                 535                 540                 


Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
545                 550                 555                 560 


Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Met Ala Arg Phe 
                565                 570                 575     


Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr Glu 
            580                 585                 590         


Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys Lys 
        595                 600                 605             


Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys Asp Leu 
    610                 615                 620                 


Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His Lys Cys 
625                 630                 635                 640 


Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser 
                645                 650                 655     


Val Met Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu 
            660                 665                 670         


Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu 
        675                 680                 685             


Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln 
    690                 695                 700                 


His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys 
705                 710                 715                 720 


Met Cys Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser 
                725                 730                 735     


Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn 
            740                 745                 750         


Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu 
        755                 760                 765             


Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile Ala Gly 
    770                 775                 780                 


His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu 
785                 790                 795                 800 


Arg Leu Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala Glu Pro 
                805                 810                 815     


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
            820                 825                 830         


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
        835                 840                 845             


Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
    850                 855                 860                 


Gln 
865 


<210>  113
<211>  6085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E-1 (Order-1)


<220>
<221>  misc_feature
<222>  (1368)..(1433)
<223>  encodes tPA

<220>
<221>  misc_feature
<222>  (1434)..(1925)
<223>  encodes FLT3L

<220>
<221>  misc_feature
<222>  (1932)..(2186)
<223>  16E6N

<220>
<221>  misc_feature
<222>  (1932)..(2789)
<223>  16E6/E7

<220>
<221>  misc_feature
<222>  (2187)..(2330)
<223>  16E7C

<220>
<221>  misc_feature
<222>  (2331)..(2525)
<223>  16E7N

<220>
<221>  misc_feature
<222>  (2526)..(2789)
<223>  16E6C

<220>
<221>  misc_feature
<222>  (2790)..(3671)
<223>  18E6/E7

<400>  113
taccgatgta cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta       60

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac      120

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac      180

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      240

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      300

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga      360

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt      420

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca      480

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg      540

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta      600

tataagcaga gctctctggc taactagaga acccactgct tactggctta tcgaaattaa      660

tacgactcac tatagggaga cccaagctgg ctagcgtgag tttggggacc cttgattgtt      720

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      780

tgtttagaac gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      840

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      900

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      960

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat     1020

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1080

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacatcc     1140

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1200

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctttt     1260

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     1320

tgtaatacga ctcactatag ggcgaattga agcttggtac cgccaccatg gatgctatga     1380

aacggggcct gtgctgcgtg ctgctcctgt gcggcgctgt gtttgtgagc cctagcatca     1440

cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc aaaatccgtg     1500

agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac ctgcaggacg     1560

aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg gagcggctca     1620

agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg gagatacact     1680

ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc cagaccaaca     1740

tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc tggatcactc     1800

gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca accctgccac     1860

ccccatggag tccccggccc ctggaggcca cagccccgac agccccgggc ggcggcagcg     1920

gcgatgctag catgcaccag aagagaaccg ccatgttcca ggaccctcag gagagaccta     1980

ggaagctgcc tcacctgtgt acagagctcc agacaaccat ccacgacatc atcctggagt     2040

gcgtgtactg taagcagcag ctgctgagaa gagaggtgta cgacttcgcc ttcagagacc     2100

tgtgcatcgt gtacagagac ggcaaccctt acgccgtgtg cgataagtgt ctgaagttct     2160

attccaaaat ctccgaatat aggtaccact acaacatcgt gaccttctgc tgcaagtgcg     2220

actctaccct gagactgtgc gtgcagtcta cccacgtgga catcagaacc ctggaggacc     2280

tgctgatggg caccctgggc atcgtgtgcc ctatctgctc tcagaagcct atgcacggcg     2340

acacccctac cctgcacgag tacatgctgg acctccagcc tgagaccaca gacctgtact     2400

gctacgagca gctgaacgac agctctgagg aagaggacga gattgacgga cctgctggcc     2460

aggccgagcc tgacagagcc cactacaata tcgtgacatt ctgttgcaaa tgcgactcca     2520

cactggacaa gtgcctgaag ttctacagca agatctctga gtacagatac tactgctact     2580

ctgtgtacgg caccacactg gagcagcagt acaacaagcc tctgtgcgac ctcctgatcc     2640

gctgcatcaa ctgccagaag cctctgtgcc ctgaggagaa gcagagacac ctggacaaga     2700

agcagcggtt ccacaacatc agaggcagat ggaccggcag gtgcatgtcc tgctgtagat     2760

cctccagaac cagacgggag acccagctga tggccaggtt cgaggaccct accagaagac     2820

cctacaagct gcctgacctg tgcaccgagc tgaacacctc tctgcaagac atcgagatca     2880

cctgcgtgta ctgcaagacc gtgctggagc tgaccgaggt gttcgagttc gccttcaagg     2940

acctgttcgt ggtgtacaga gacagcatcc ctcacgctgc ctgccacaag tgcatcgact     3000

tctattccag gatcagggag ctgcgctatt actccgactc tgtgatgtac ggccccaagg     3060

ccaccctcca ggacatcgtg ctgcacctgg agcctcagaa cgagatcccc gtggacctgc     3120

tgtgccacga gcagctgtct gactctgaag aggagaacga cgagatcgac ggcgtgaacc     3180

accagcacct gcctgccagg agagctgaac cccagcggca taccatgctg tgtatgtgct     3240

tctactctag gatcagagag ctgaggtact actctgactc tgtgtacggc gacaccctgg     3300

agaagctgac caacaccggc ctgtacaacc tgctgatccg gtgcctgagg tgccagaagc     3360

ctctgaaccc tgccgagaag ctgagacacc tgaacgagaa gagaagattc cacaagatcg     3420

ctggccacta cagaggccag tgccactctt gctgcaacag agccagacag gagagactcc     3480

agcggagaag ggagacccag gtggccagaa gagccgagcc tcagagacac accatgctgt     3540

gcatgtgctg caagtgcgag gccagaatcg agctggtggt ggagagctct gccgacgacc     3600

tgagagcctt ccagcagctg ttcctgtcta ccctgagctt cgtgtgccct tggtgcgcct     3660

ctcagcagta atctagagtc ggggcggccg gccgcttcga gcagacatga taagatacat     3720

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     3780

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     3840

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa     3900

gtaaaacctc tacaaatgtg gtaaaatcga taaggatctg aacgatggag cggagaatgg     3960

gcggaactgg gcggagttag gggcgggatg ggcggagtta ggggcgggac tatggttgct     4020

gactaattga gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca     4080

cacctggttg ctgactaatt gagatgcatg ctttgcatac ttctgcctgc tggggagcct     4140

ggggactttc cacaccctaa ctgacacaca ttccacagcg gatccgtcga cttcagaaga     4200

actcgtcaag aaggcgatag aaggcgatgc gccgcgaatc gggagcggcg ataccgtaga     4260

gcacgaggaa gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca     4320

acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa     4380

agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat     4440

cctcgccgtc gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct     4500

gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc     4560

gctcgatgcg atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca     4620

gccgccgcat tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca     4680

ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa     4740

cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct     4800

cgtcttgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc     4860

cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt     4920

catagccgaa tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt     4980

caatcatgcg aaacgatcct catcctgtct cttgatcaga tcttgatccc ctgcgccatc     5040

agatccttgg cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag     5100

agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct     5160

atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg     5220

tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc ggactggctt     5280

tctacgtgaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt     5340

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt     5400

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag     5460

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca     5520

gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca     5580

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg     5640

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg     5700

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct     5760

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     5820

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     5880

ttccaggggg aaacgcccgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     5940

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     6000

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc gggcccaatc     6060

gacccgggcg acggccagtg aattg                                           6085


<210>  114
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-1

<400>  114

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ile Thr Gln Asp Cys Ser Phe Gln His 
            20                  25                  30          


Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
        35                  40                  45              


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
65                  70                  75                  80  


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 
                85                  90                  95      


Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 
            100                 105                 110         


Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 
        115                 120                 125             


Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 
    130                 135                 140                 


Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 
145                 150                 155                 160 


Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala 
                165                 170                 175     


Pro Thr Ala Pro Gly Gly Gly Ser Gly Asp Ala Ser Met His Gln Lys 
            180                 185                 190         


Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro 
        195                 200                 205             


His Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu 
    210                 215                 220                 


Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe 
225                 230                 235                 240 


Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
                245                 250                 255     


Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
            260                 265                 270         


Tyr His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu 
        275                 280                 285             


Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp 
    290                 295                 300                 


Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys 
305                 310                 315                 320 


Pro Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu 
                325                 330                 335     


Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser 
            340                 345                 350         


Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro 
        355                 360                 365             


Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser 
    370                 375                 380                 


Thr Leu Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg 
385                 390                 395                 400 


Tyr Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn 
                405                 410                 415     


Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro 
            420                 425                 430         


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe 
        435                 440                 445             


His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg 
    450                 455                 460                 


Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu Met Ala Arg Phe Glu Asp 
465                 470                 475                 480 


Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr Glu Leu Asn 
                485                 490                 495     


Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys Lys Thr Val 
            500                 505                 510         


Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys Asp Leu Phe Val 
        515                 520                 525             


Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His Lys Cys Ile Asp 
    530                 535                 540                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Met 
545                 550                 555                 560 


Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro 
                565                 570                 575     


Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp 
            580                 585                 590         


Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu 
        595                 600                 605             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys 
    610                 615                 620                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Tyr 
625                 630                 635                 640 


Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu 
                645                 650                 655     


Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu Lys Leu 
            660                 665                 670         


Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile Ala Gly His Tyr 
        675                 680                 685             


Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu 
    690                 695                 700                 


Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala Glu Pro Gln Arg 
705                 710                 715                 720 


His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu 
                725                 730                 735     


Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe 
            740                 745                 750         


Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln 
        755                 760                 765         


<210>  115
<211>  6085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E-2 (Order-2)


<220>
<221>  misc_feature
<222>  (1368)..(1433)
<223>  encodes tPA

<220>
<221>  misc_feature
<222>  (1434)..(1925)
<223>  encodes FLT3L

<220>
<221>  misc_feature
<222>  (1932)..(2195)
<223>  16E6C

<220>
<221>  misc_feature
<222>  (1932)..(2789)
<223>  16E6/E7

<220>
<221>  misc_feature
<222>  (2196)..(2339)
<223>  16E7C

<220>
<221>  misc_feature
<222>  (2340)..(2594)
<223>  16E6N

<220>
<221>  misc_feature
<222>  (2595)..(2789)
<223>  16E7N

<220>
<221>  misc_feature
<222>  (2790)..(3671)
<223>  18E6/E7

<400>  115
taccgatgta cgggccagat atacgcgttg acattgatta ttgactagtt attaatagta       60

atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac      120

ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac      180

gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt      240

acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat      300

tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga      360

ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt      420

ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca      480

ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg      540

tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta      600

tataagcaga gctctctggc taactagaga acccactgct tactggctta tcgaaattaa      660

tacgactcac tatagggaga cccaagctgg ctagcgtgag tttggggacc cttgattgtt      720

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      780

tgtttagaac gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      840

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      900

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      960

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat     1020

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1080

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacatcc     1140

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1200

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctttt     1260

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     1320

tgtaatacga ctcactatag ggcgaattga agcttggtac cgccaccatg gatgctatga     1380

aacggggcct gtgctgcgtg ctgctcctgt gcggcgctgt gtttgtgagc cctagcatca     1440

cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc aaaatccgtg     1500

agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac ctgcaggacg     1560

aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg gagcggctca     1620

agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg gagatacact     1680

ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc cagaccaaca     1740

tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc tggatcactc     1800

gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca accctgccac     1860

ccccatggag tccccggccc ctggaggcca cagccccgac agccccgggc ggcggcagcg     1920

gcgatgctag cgacaagtgc ctgaagttct acagcaagat ctctgagtac agatactact     1980

gctactctgt gtacggcacc acactggagc agcagtacaa caagcctctg tgcgacctcc     2040

tgatccgctg catcaactgc cagaagcctc tgtgccctga ggagaagcag agacacctgg     2100

acaagaagca gcggttccac aacatcagag gcagatggac cggcaggtgc atgtcctgct     2160

gtagatcctc cagaaccaga cgggagaccc agctgcacta caacatcgtg accttctgct     2220

gcaagtgcga ctctaccctg agactgtgcg tgcagtctac ccacgtggac atcagaaccc     2280

tggaggacct gctgatgggc accctgggca tcgtgtgccc tatctgctct cagaagccta     2340

tgcaccagaa gagaaccgcc atgttccagg accctcagga gagacctagg aagctgcctc     2400

acctgtgtac agagctccag acaaccatcc acgacatcat cctggagtgc gtgtactgta     2460

agcagcagct gctgagaaga gaggtgtacg acttcgcctt cagagacctg tgcatcgtgt     2520

acagagacgg caacccttac gccgtgtgcg ataagtgtct gaagttctat tccaaaatct     2580

ccgaatatag gtacatgcac ggcgacaccc ctaccctgca cgagtacatg ctggacctcc     2640

agcctgagac cacagacctg tactgctacg agcagctgaa cgacagctct gaggaagagg     2700

acgagattga cggacctgct ggccaggccg agcctgacag agcccactac aatatcgtga     2760

cattctgttg caaatgcgac tccacactga tggccaggtt cgaggaccct accagaagac     2820

cctacaagct gcctgacctg tgcaccgagc tgaacacctc tctgcaagac atcgagatca     2880

cctgcgtgta ctgcaagacc gtgctggagc tgaccgaggt gttcgagttc gccttcaagg     2940

acctgttcgt ggtgtacaga gacagcatcc ctcacgctgc ctgccacaag tgcatcgact     3000

tctattccag gatcagggag ctgcgctatt actccgactc tgtgatgtac ggccccaagg     3060

ccaccctcca ggacatcgtg ctgcacctgg agcctcagaa cgagatcccc gtggacctgc     3120

tgtgccacga gcagctgtct gactctgaag aggagaacga cgagatcgac ggcgtgaacc     3180

accagcacct gcctgccagg agagctgaac cccagcggca taccatgctg tgtatgtgct     3240

tctactctag gatcagagag ctgaggtact actctgactc tgtgtacggc gacaccctgg     3300

agaagctgac caacaccggc ctgtacaacc tgctgatccg gtgcctgagg tgccagaagc     3360

ctctgaaccc tgccgagaag ctgagacacc tgaacgagaa gagaagattc cacaagatcg     3420

ctggccacta cagaggccag tgccactctt gctgcaacag agccagacag gagagactcc     3480

agcggagaag ggagacccag gtggccagaa gagccgagcc tcagagacac accatgctgt     3540

gcatgtgctg caagtgcgag gccagaatcg agctggtggt ggagagctct gccgacgacc     3600

tgagagcctt ccagcagctg ttcctgtcta ccctgagctt cgtgtgccct tggtgcgcct     3660

ctcagcagta atctagagtc ggggcggccg gccgcttcga gcagacatga taagatacat     3720

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     3780

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     3840

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa     3900

gtaaaacctc tacaaatgtg gtaaaatcga taaggatctg aacgatggag cggagaatgg     3960

gcggaactgg gcggagttag gggcgggatg ggcggagtta ggggcgggac tatggttgct     4020

gactaattga gatgcatgct ttgcatactt ctgcctgctg gggagcctgg ggactttcca     4080

cacctggttg ctgactaatt gagatgcatg ctttgcatac ttctgcctgc tggggagcct     4140

ggggactttc cacaccctaa ctgacacaca ttccacagcg gatccgtcga cttcagaaga     4200

actcgtcaag aaggcgatag aaggcgatgc gccgcgaatc gggagcggcg ataccgtaga     4260

gcacgaggaa gcggtcagcc cattcgccgc caagctcttc agcaatatca cgggtagcca     4320

acgctatgtc ctgatagcgg tccgccacac ccagccggcc acagtcgatg aatccagaaa     4380

agcggccatt ttccaccatg atattcggca agcaggcatc gccatgggtc acgacgagat     4440

cctcgccgtc gggcatgctc gccttgagcc tggcgaacag ttcggctggc gcgagcccct     4500

gatgctcttc gtccagatca tcctgatcga caagaccggc ttccatccga gtacgtgctc     4560

gctcgatgcg atgtttcgct tggtggtcga atgggcaggt agccggatca agcgtatgca     4620

gccgccgcat tgcatcagcc atgatggata ctttctcggc aggagcaagg tgagatgaca     4680

ggagatcctg ccccggcact tcgcccaata gcagccagtc ccttcccgct tcagtgacaa     4740

cgtcgagcac agctgcgcaa ggaacgcccg tcgtggccag ccacgatagc cgcgctgcct     4800

cgtcttgcag ttcattcagg gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc     4860

cctgcgctga cagccggaac acggcggcat cagagcagcc gattgtctgt tgtgcccagt     4920

catagccgaa tagcctctcc acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt     4980

caatcatgcg aaacgatcct catcctgtct cttgatcaga tcttgatccc ctgcgccatc     5040

agatccttgg cggcaagaaa gccatccagt ttactttgca gggcttccca accttaccag     5100

agggcgcccc agctggcaat tccggttcgc ttgctgtcca taaaaccgcc cagtctagct     5160

atcgccatgt aagcccactg caagctacct gctttctctt tgcgcttgcg ttttcccttg     5220

tccagatagc ccagtagctg acattcatcc ggggtcagca ccgtttctgc ggactggctt     5280

tctacgtgaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt     5340

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt     5400

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag     5460

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca     5520

gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca     5580

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg     5640

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg     5700

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct     5760

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     5820

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     5880

ttccaggggg aaacgcccgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     5940

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     6000

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc gggcccaatc     6060

gacccgggcg acggccagtg aattg                                           6085


<210>  116
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-2

<400>  116

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ile Thr Gln Asp Cys Ser Phe Gln His 
            20                  25                  30          


Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 
        35                  40                  45              


Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 
    50                  55                  60                  


Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 
65                  70                  75                  80  


Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 
                85                  90                  95      


Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 
            100                 105                 110         


Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 
        115                 120                 125             


Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 
    130                 135                 140                 


Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 
145                 150                 155                 160 


Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala Thr Ala 
                165                 170                 175     


Pro Thr Ala Pro Gly Gly Gly Ser Gly Asp Ala Ser Asp Lys Cys Leu 
            180                 185                 190         


Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Val 
        195                 200                 205             


Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu 
    210                 215                 220                 


Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys 
225                 230                 235                 240 


Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg 
                245                 250                 255     


Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg 
            260                 265                 270         


Glu Thr Gln Leu His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp 
        275                 280                 285             


Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr 
    290                 295                 300                 


Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys 
305                 310                 315                 320 


Ser Gln Lys Pro Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro 
                325                 330                 335     


Gln Glu Arg Pro Arg Lys Leu Pro His Leu Cys Thr Glu Leu Gln Thr 
            340                 345                 350         


Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu 
        355                 360                 365             


Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val 
    370                 375                 380                 


Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe 
385                 390                 395                 400 


Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Met His Gly Asp Thr Pro Thr 
                405                 410                 415     


Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr 
            420                 425                 430         


Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp 
        435                 440                 445             


Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val 
    450                 455                 460                 


Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Met Ala Arg Phe Glu Asp 
465                 470                 475                 480 


Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp Leu Cys Thr Glu Leu Asn 
                485                 490                 495     


Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys Val Tyr Cys Lys Thr Val 
            500                 505                 510         


Leu Glu Leu Thr Glu Val Phe Glu Phe Ala Phe Lys Asp Leu Phe Val 
        515                 520                 525             


Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His Lys Cys Ile Asp 
    530                 535                 540                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Met 
545                 550                 555                 560 


Tyr Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro 
                565                 570                 575     


Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp 
            580                 585                 590         


Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu 
        595                 600                 605             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys 
    610                 615                 620                 


Phe Tyr Ser Arg Ile Arg Glu Leu Arg Tyr Tyr Ser Asp Ser Val Tyr 
625                 630                 635                 640 


Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu Tyr Asn Leu Leu 
                645                 650                 655     


Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Asn Pro Ala Glu Lys Leu 
            660                 665                 670         


Arg His Leu Asn Glu Lys Arg Arg Phe His Lys Ile Ala Gly His Tyr 
        675                 680                 685             


Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu 
    690                 695                 700                 


Gln Arg Arg Arg Glu Thr Gln Val Ala Arg Arg Ala Glu Pro Gln Arg 
705                 710                 715                 720 


His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu 
                725                 730                 735     


Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe 
            740                 745                 750         


Leu Ser Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln
        755                 760                 765             


