                         SEQUENCE LISTING

<110>  MASCOMA CORPORATION
       Froehlich, Allan
       Henningsen, Brooks
 
<120>  CHIMERIC POLYPEPTIDES HAVING XYLOSE ISOMERASE ACTIVITY

<130>  115235-193

<150>  62/035,752
<151>  2014-08-11

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Xylose Isomerase 1

<400>  1

Met Ser Glu Leu Phe Gln Asn Ile Pro Lys Ile Lys Tyr Glu Gly Ala 
1               5                   10                  15      


Asn Ser Lys Asn Pro Leu Ala Phe His Tyr Tyr Asp Ala Glu Lys Glu 
            20                  25                  30          


Ile Met Gly Lys Lys Met Lys Asp Trp Leu Arg Phe Ala Met Ala Trp 
        35                  40                  45              


Trp His Thr Leu Cys Ala Glu Gly Ser Asp Gln Phe Gly Pro Gly Thr 
    50                  55                  60                  


Lys Thr Phe Pro Trp Asn Glu Gly Thr Asp Pro Ile Glu Lys Ala Lys 
65                  70                  75                  80  


Gln Lys Val Asp Ala Gly Phe Glu Ile Met Thr Lys Leu Gly Ile Glu 
                85                  90                  95      


His Tyr Cys Phe His Asp Val Asp Leu Val Asp Glu Gly Lys Asn Val 
            100                 105                 110         


Glu Glu Tyr Glu Lys Asn Leu Lys Thr Ile Val Ala Tyr Leu Lys Glu 
        115                 120                 125             


Lys Gln Lys Glu Thr Gly Ile Lys Leu Leu Trp Gly Thr Ala Asn Val 
    130                 135                 140                 


Phe Gly His Ala Arg Tyr Met Asn Gly Ala Ala Thr Asn Pro Asp Phe 
145                 150                 155                 160 


Asp Val Val Ala Arg Ala Ala Val Gln Ile Lys Asn Ala Ile Asp Ala 
                165                 170                 175     


Thr Ile Glu Leu Gly Gly Glu Asn Tyr Val Phe Trp Gly Gly Arg Glu 
            180                 185                 190         


Gly Tyr Met Ser Leu Leu Asn Thr Asn Met Lys Arg Glu Lys Asp His 
        195                 200                 205             


Leu Ala Met Met Leu Thr Met Ala Arg Asp Tyr Gly Arg Lys Asn Gly 
    210                 215                 220                 


Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro Thr Lys 
225                 230                 235                 240 


His Gln Tyr Asp Val Asp Ser Glu Thr Val Ile Gly Phe Leu Arg His 
                245                 250                 255     


Tyr Gly Leu Asp Lys Asp Phe Ala Leu Asn Ile Glu Val Asn His Ala 
            260                 265                 270         


Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Gln Ala Ala Ala Asp 
        275                 280                 285             


Ala Gly Met Leu Cys Ser Ile Asp Ala Asn Arg Gly Asp Tyr Gln Asn 
    290                 295                 300                 


Gly Trp Asp Thr Asp Gln Phe Pro Met Asp Ile Tyr Glu Leu Ala Gln 
305                 310                 315                 320 


Ala Trp Leu Val Ile Leu Glu Gly Gly Gly Leu Thr Thr Gly Gly Thr 
                325                 330                 335     


Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu Asp Ile 
            340                 345                 350         


Phe Ile Ala His Ile Gly Gly Met Asp Ala Phe Ala Arg Ala Leu Met 
        355                 360                 365             


Ile Ala Ala Asp Ile Leu Glu Asn Ser Asp Tyr Arg Lys Met Arg Ala 
    370                 375                 380                 


Glu Arg Tyr Ala Ser Phe Asp Ala Gly Glu Gly Lys Ala Phe Glu Asp 
385                 390                 395                 400 


Gly Lys Leu Thr Leu Glu Asp Leu Arg Thr Ile Ala Leu Arg Asp Gly 
                405                 410                 415     


Glu Pro Lys Gln Ile Ser Gly Lys Gln Glu Leu Tyr Glu Met Ile Val 
            420                 425                 430         


Asn Leu His Ile 
        435     


<210>  2
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric Xylose Isomerase 1

<400>  2
atgtctgaat tgttccaaaa catcccaaag atcaagtacg aaggtgctaa ctctaagaac       60

ccattggctt tccactacta cgacgctgaa aaggaaatca tgggtaagaa gatgaaggac      120

tggttgagat tcgctatggc ttggtggcac actttgtgtg ctgaaggttc tgaccaattc      180

ggtccaggta ctaagacttt cccatggaac gaaggtactg acccaatcga aaaggctaag      240

caaaaggttg acgctggttt cgaaatcatg actaagttgg gtatcgaaca ctactgtttc      300

cacgacgttg acttggttga cgaaggtaag aacgttgaag aatacgaaaa gaacttgaag      360

actatcgttg cttacttgaa ggaaaagcaa aaggaaactg gtatcaagtt gttgtggggt      420

actgctaacg ttttcggtca cgctagatac atgaacggtg ctgctactaa cccagacttc      480

gacgttgttg ccagagctgc tgttcaaatt aagaacgcta ttgacgctac tattgaattg      540

ggtggtgaaa actacgtttt ctggggtggt agagaaggtt acatgtcttt gttgaacacc      600

aacatgaaga gagaaaagga tcatttggcc atgatgttga ctatggctag agattacggt      660

agaaagaatg gtttcaaggg tactttcttg atcgaaccta aacctatgga acctactaag      720

caccaatacg atgttgattc cgaaaccgtt atcggtttct tgagacatta cggtttggat      780

aaggatttcg ccttgaacat cgaagttaac catgctactt tggctggtca tactttcgaa      840

catgaattgc aagctgctgc tgatgctggt atgttgtgtt ctattgatgc taacagaggt      900

gactaccaaa atggttggga tactgatcaa ttcccaatgg atatctacga attggctcaa      960

gcttggttgg ttattttgga aggtggtggt ttgactactg gtggtactaa ttttgatgcc     1020

aagaccagaa gaaactccac tgatttggaa gacatcttca ttgcccatat cggtggtatg     1080

gatgcttttg ctagagcttt gatgattgct gccgatattt tggaaaactc cgactacaga     1140

aagatgagag ctgaaagata cgcttctttt gatgctggtg aaggtaaggc tttcgaagat     1200

ggtaaattga ccttggaaga tttgagaacc attgctttga gagatggtga acctaagcaa     1260

atttccggta agcaagaatt atacgaaatg atcgtcaact tgcacatcta a              1311


<210>  3
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Xylose Isomerase 2

<400>  3

Met Ala Lys Glu Tyr Phe Pro Phe Thr Gly Lys Ile Pro Phe Glu Gly 
1               5                   10                  15      


Lys Asp Ser Lys Asn Val Met Ala Phe His Tyr Tyr Glu Pro Glu Lys 
            20                  25                  30          


Val Val Met Gly Lys Lys Met Lys Asp Trp Leu Lys Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Gly Gly Ala Ser Ala Asp Gln Phe Gly Gly Gln 
    50                  55                  60                  


Thr Arg Ser Tyr Glu Trp Asp Lys Ala Ala Asp Ala Val Gln Arg Ala 
65                  70                  75                  80  


Lys Asp Lys Met Asp Ala Gly Phe Glu Ile Met Asp Lys Leu Gly Ile 
                85                  90                  95      


Glu Tyr Phe Cys Phe His Asp Val Asp Leu Val Glu Glu Gly Glu Thr 
            100                 105                 110         


Ile Ala Glu Tyr Glu Arg Arg Met Lys Glu Ile Thr Asp Tyr Ala Leu 
        115                 120                 125             


Val Lys Met Lys Glu Tyr Pro Asn Ile Lys Leu Leu Trp Gly Thr Ala 
    130                 135                 140                 


Asn Val Phe Gly His Ala Arg Tyr Met Asn Gly Ala Ala Thr Asn Pro 
145                 150                 155                 160 


Asp Phe Asp Val Val Ala Arg Ala Ala Val Gln Ile Lys Asn Ala Ile 
                165                 170                 175     


Asp Ala Thr Ile Glu Leu Gly Gly Glu Asn Tyr Val Phe Trp Gly Gly 
            180                 185                 190         


Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asn Met Lys Arg Glu Lys 
        195                 200                 205             


Asp His Leu Ala Met Met Leu Thr Met Ala Arg Asp Tyr Gly Arg Lys 
    210                 215                 220                 


Asn Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro 
225                 230                 235                 240 


Thr Lys His Gln Tyr Asp Val Asp Ser Glu Thr Val Ile Gly Phe Leu 
                245                 250                 255     


Arg His Tyr Gly Leu Asp Lys Asp Phe Ala Leu Asn Ile Glu Val Asn 
            260                 265                 270         


His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Gln Ala Ala 
        275                 280                 285             


Ala Asp Ala Gly Met Leu Cys Ser Ile Asp Ala Asn Arg Gly Asp Tyr 
    290                 295                 300                 


Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Met Asp Ile Tyr Glu Leu 
305                 310                 315                 320 


Ala Gln Ala Trp Leu Val Ile Leu Glu Gly Gly Gly Leu Thr Thr Gly 
                325                 330                 335     


Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu 
            340                 345                 350         


Asp Ile Phe Ile Ala His Ile Gly Gly Met Asp Ala Phe Ala Arg Ala 
        355                 360                 365             


Leu Met Ile Ala Ala Asp Ile Leu Glu Asn Ser Asp Tyr Arg Lys Met 
    370                 375                 380                 


Arg Ala Glu Arg Tyr Ala Ser Phe Asp Ala Gly Glu Gly Lys Ala Phe 
385                 390                 395                 400 


Glu Asp Gly Lys Leu Thr Leu Glu Asp Leu Arg Thr Ile Ala Leu Arg 
                405                 410                 415     


Asp Gly Glu Pro Lys Gln Ile Ser Gly Lys Gln Glu Leu Tyr Glu Met 
            420                 425                 430         


Ile Val Asn Leu His Ile 
        435             


<210>  4
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric Xylose Isomerase 2

<400>  4
atggctaagg aatacttccc attcactggt aagatcccat tcgaaggtaa ggactctaag       60

aacgttatgg ctttccacta ctacgaacca gaaaaggttg ttatgggtaa gaagatgaag      120

gactggttga agttcgctat ggcttggtgg cacactttgg gtggtgcttc tgctgaccaa      180

ttcggtggtc aaactagatc ttacgaatgg gacaaggctg ctgacgctgt tcaaagagct      240

aaggacaaga tggacgctgg tttcgaaatc atggacaagt tgggtatcga atacttctgt      300

ttccacgacg ttgacttggt tgaagaaggt gaaactatcg ctgaatacga aagaagaatg      360

aaggaaatca ctgactacgc tttggttaag atgaaggaat acccaaacat caagttgttg      420

tggggtactg ctaacgtttt cggtcacgct agatacatga acggtgctgc tactaaccca      480

gacttcgacg ttgttgccag agctgctgtt caaattaaga acgctattga cgctactatt      540

gaattgggtg gtgaaaacta cgttttctgg ggtggtagag aaggttacat gtctttgttg      600

aacaccaaca tgaagagaga aaaggatcat ttggccatga tgttgactat ggctagagat      660

tacggtagaa agaatggttt caagggtact ttcttgatcg aacctaaacc tatggaacct      720

actaagcacc aatacgatgt tgattccgaa accgttatcg gtttcttgag acattacggt      780

ttggataagg atttcgcctt gaacatcgaa gttaaccatg ctactttggc tggtcatact      840

ttcgaacatg aattgcaagc tgctgctgat gctggtatgt tgtgttctat tgatgctaac      900

agaggtgact accaaaatgg ttgggatact gatcaattcc caatggatat ctacgaattg      960

gctcaagctt ggttggttat tttggaaggt ggtggtttga ctactggtgg tactaatttt     1020

gatgccaaga ccagaagaaa ctccactgat ttggaagaca tcttcattgc ccatatcggt     1080

ggtatggatg cttttgctag agctttgatg attgctgccg atattttgga aaactccgac     1140

tacagaaaga tgagagctga aagatacgct tcttttgatg ctggtgaagg taaggctttc     1200

gaagatggta aattgacctt ggaagatttg agaaccattg ctttgagaga tggtgaacct     1260

aagcaaattt ccggtaagca agaattatac gaaatgatcg tcaacttgca catctaa        1317


<210>  5
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric Xylose Isomerase 3

<400>  5

Met Val Lys Glu Tyr Phe Pro Ala Ile Gln Lys Ile Lys Phe Glu Gly 
1               5                   10                  15      


Lys Asp Ser Lys Asn Pro Met Ala Phe His Tyr Tyr Asp Ala Glu Lys 
            20                  25                  30          


Glu Ile Met Gly Lys Lys Met Lys Asp Trp Leu Arg Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Cys Ala Glu Gly Ser Asp Gln Phe Gly Pro Gly 
    50                  55                  60                  


Thr Lys Thr Phe Pro Trp Asn Glu Gly Thr Asp Pro Ile Glu Lys Ala 
65                  70                  75                  80  


Lys Gln Lys Val Asp Ala Gly Phe Glu Ile Met Thr Lys Leu Gly Ile 
                85                  90                  95      


Glu His Tyr Cys Phe His Asp Val Asp Leu Val Asp Glu Gly Lys Asn 
            100                 105                 110         


Val Glu Glu Tyr Glu Lys Asn Leu Lys Thr Ile Val Ala Tyr Leu Lys 
        115                 120                 125             


Glu Lys Gln Lys Glu Thr Gly Ile Lys Leu Leu Trp Ser Thr Ala Asn 
    130                 135                 140                 


Val Phe Gly His Lys Arg Tyr Met Asn Gly Ala Ala Thr Asn Pro Tyr 
145                 150                 155                 160 


Phe Pro Thr Val Ala Cys Val Gly Thr Gln Ile Lys Asn Ala Ile Asp 
                165                 170                 175     


Ala Cys Ile Ala Leu Gly Gly Glu Asn Tyr Val Phe Trp Gly Gly Arg 
            180                 185                 190         


Glu Gly Tyr Met Ser Leu Leu Asn Thr Asn Met Lys Arg Glu Lys Asp 
        195                 200                 205             


His Leu Ala Met Met Leu Thr Met Ala Arg Asp Tyr Gly Arg Lys Asn 
    210                 215                 220                 


Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro Thr 
225                 230                 235                 240 


Lys His Gln Tyr Asp Val Asp Ser Glu Thr Val Ile Gly Phe Leu Arg 
                245                 250                 255     


His Tyr Gly Leu Asp Lys Asp Phe Ala Leu Asn Ile Glu Val Asn His 
            260                 265                 270         


Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Gln Ala Ala Ala 
        275                 280                 285             


Asp Ala Gly Met Leu Cys Ser Ile Asp Ala Asn Arg Gly Asp Tyr Gln 
    290                 295                 300                 


Asn Gly Trp Asp Thr Asp Gln Phe Pro Met Asp Ile Tyr Glu Leu Ala 
305                 310                 315                 320 


Gln Ala Trp Leu Val Ile Leu Glu Gly Gly Gly Leu Thr Thr Gly Gly 
                325                 330                 335     


Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu Asp 
            340                 345                 350         


Ile Phe Ile Ala His Ile Gly Gly Met Asp Ala Phe Ala Arg Ala Leu 
        355                 360                 365             


Met Ile Ala Ala Asp Ile Leu Glu Asn Ser Asp Tyr Arg Lys Met Arg 
    370                 375                 380                 


Ala Glu Arg Tyr Ala Ser Phe Asp Ala Gly Glu Gly Lys Ala Phe Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Thr Leu Glu Asp Leu Arg Thr Ile Ala Leu Arg Asp 
                405                 410                 415     


Gly Glu Pro Lys Gln Ile Ser Gly Lys Gln Glu Leu Tyr Glu Met Ile 
            420                 425                 430         


Val Asn Leu His Ile 
        435         


<210>  6
<211>  1314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric Xylose Isomerase 3

<400>  6
atggttaagg aatacttccc agctatccaa aagatcaagt tcgaaggtaa ggactctaag       60

aacccaatgg ctttccacta ctacgacgct gaaaaggaaa tcatgggtaa gaagatgaag      120

gactggttga gattcgctat ggcttggtgg cacactttgt gtgctgaagg ttctgaccaa      180

ttcggtccag gtactaagac tttcccatgg aacgaaggta ctgacccaat cgaaaaggct      240

aagcaaaagg ttgacgctgg tttcgaaatc atgactaagt tgggtatcga acactactgt      300

ttccacgacg ttgacttggt tgacgaaggt aagaacgttg aagaatacga aaagaacttg      360

aagactatcg ttgcttactt gaaggaaaag caaaaggaaa ctggtatcaa gttgttgtgg      420

tctactgcta acgttttcgg tcacaagaga tatatgaacg gtgctgctac taatccatac      480

tttccaactg ttgcttgcgt tggtactcaa atcaagaatg ctattgatgc ttgcattgct      540

ttgggtggtg aaaattatgt tttctggggt ggtagagaag gttacatgtc tttgttgaac      600

accaacatga agagagaaaa ggatcatttg gccatgatgt tgactatggc tagagattac      660

ggtagaaaga atggtttcaa gggtactttc ttgatcgaac ctaaacctat ggaacctact      720

aagcaccaat acgatgttga ttccgaaacc gttatcggtt tcttgagaca ttacggtttg      780

gataaggatt tcgccttgaa catcgaagtt aaccatgcta ctttggctgg tcatactttc      840

gaacatgaat tgcaagctgc tgctgatgct ggtatgttgt gttctattga tgctaacaga      900

ggtgactacc aaaatggttg ggatactgat caattcccaa tggatatcta cgaattggct      960

caagcttggt tggttatttt ggaaggtggt ggtttgacta ctggtggtac taattttgat     1020

gccaagacca gaagaaactc cactgatttg gaagacatct tcattgccca tatcggtggt     1080

atggatgctt ttgctagagc tttgatgatt gctgccgata ttttggaaaa ctccgactac     1140

agaaagatga gagctgaaag atacgcttct tttgatgctg gtgaaggtaa ggctttcgaa     1200

gatggtaaat tgaccttgga agatttgaga accattgctt tgagagatgg tgaacctaag     1260

caaatttccg gtaagcaaga attatacgaa atgatcgtca acttgcacat ctaa           1314


<210>  7
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Directed Chimeric Xylose Isomerase 1

<400>  7

Met Ala Lys Glu Tyr Phe Pro Phe Thr Gly Lys Ile Pro Phe Glu Gly 
1               5                   10                  15      


Lys Asp Ser Lys Asn Val Met Ala Phe His Tyr Tyr Glu Pro Glu Lys 
            20                  25                  30          


Val Val Met Gly Lys Lys Met Lys Asp Trp Leu Lys Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Gly Gly Ala Ser Ala Asp Gln Phe Gly Gly Gln 
    50                  55                  60                  


Thr Arg Ser Tyr Glu Trp Asp Lys Ala Ala Asp Ala Val Gln Arg Ala 
65                  70                  75                  80  


Lys Asp Lys Met Asp Ala Gly Phe Glu Ile Met Asp Lys Leu Gly Ile 
                85                  90                  95      


Glu Tyr Phe Cys Phe His Asp Val Asp Leu Val Glu Glu Gly Glu Thr 
            100                 105                 110         


Ile Ala Glu Tyr Glu Arg Arg Met Lys Glu Ile Thr Asp Tyr Ala Leu 
        115                 120                 125             


Val Lys Met Lys Glu Tyr Pro Asn Ile Lys Leu Leu Trp Gly Thr Ala 
    130                 135                 140                 


Asn Val Phe Gly Asn Lys Arg Tyr Ala Asn Gly Ala Ser Thr Asn Pro 
145                 150                 155                 160 


Asp Phe Asp Val Val Ala Arg Ala Ile Val Gln Ile Lys Asn Ala Ile 
                165                 170                 175     


Asp Ala Thr Ile Lys Leu Gly Gly Thr Asn Tyr Val Phe Trp Gly Gly 
            180                 185                 190         


Arg Glu Gly Tyr Met Thr Leu Leu Asn Thr Asp Met Lys Arg Glu Gln 
        195                 200                 205             


Glu His Leu Ala Arg Phe Leu Thr Met Ala Lys Asp Tyr Ala Arg Lys 
    210                 215                 220                 


Gln Gly Phe Thr Gly Thr Phe Phe Ile Glu Pro Lys Pro Cys Glu Pro 
225                 230                 235                 240 


Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val Ile Gly Phe Leu 
                245                 250                 255     


Arg His Phe Gly Leu Asp Lys Asp Phe Lys Leu Asn Leu Glu Val Asn 
            260                 265                 270         


His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Ala Cys Ala 
        275                 280                 285             


Val Asp Ala Gly Met Leu Gly Ser Ile Asp Ala Asn Arg Gly Asp Tyr 
    290                 295                 300                 


Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Ile Asp Gln Tyr Glu Leu 
305                 310                 315                 320 


Val Gln Ala Trp Met Glu Ile Ile Arg Gly Gly Gly Phe Thr Thr Gly 
                325                 330                 335     


Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu 
            340                 345                 350         


Asp Ile Ile Ile Ala His Ile Ser Gly Met Asp Ala Met Ala Arg Ala 
        355                 360                 365             


Leu Glu Asn Ala Ala Lys Leu Leu Thr Glu Ser Pro Tyr Lys Lys Met 
    370                 375                 380                 


Lys Ala Asp Arg Tyr Ala Ser Phe Asp Ser Gly Met Gly Lys Asp Phe 
385                 390                 395                 400 


Glu Asp Gly Lys Leu Thr Phe Glu Gln Val Tyr Glu Tyr Gly Lys Lys 
                405                 410                 415     


Val Asn Glu Pro Lys Gln Thr Ser Gly Lys Gln Glu Leu Tyr Glu Ala 
            420                 425                 430         


Ile Val Ala Met Tyr Met 
        435             


<210>  8
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Directed Chimeric Xylose Isomerase 1

<400>  8
atggctaagg aatacttccc attcactggt aagatcccat tcgaaggtaa ggactctaag       60

aacgttatgg ctttccacta ctacgaacca gaaaaggttg ttatgggtaa gaagatgaag      120

gactggttga agttcgctat ggcttggtgg cacactttgg gtggtgcttc tgctgaccaa      180

ttcggtggtc aaactagatc ttacgaatgg gacaaggctg ctgacgctgt tcaaagagct      240

aaggacaaga tggacgctgg tttcgaaatc atggacaagt tgggtatcga atacttctgt      300

ttccacgacg ttgacttggt tgaagaaggt gaaactatcg ctgaatacga aagaagaatg      360

aaggaaatca ctgactacgc tttggttaag atgaaggaat acccaaacat caagttgttg      420

tggggtactg ctaacgtttt cggtaacaag agatacgcta acggtgcttc tactaaccca      480

gacttcgacg ttgttgctag agctatcgtt caaatcaaga acgctatcga cgctactatc      540

aagttgggtg gtactaacta cgttttctgg ggtggtagag aaggttacat gactttgttg      600

aacaccgaca tgaagagaga acaagaacat ttggctagat tcttgaccat ggctaaagat      660

tacgctagaa agcaaggttt caccggtact tttttcattg aacctaagcc atgcgaacct      720

accaaacatc aatatgatta cgatgctgcc accgttattg gttttttgag acatttcggt      780

ttggacaagg acttcaagtt gaacttggaa gttaaccatg ctactttggc tggtcacact      840

ttcgaacacg aattggcttg tgctgttgac gctggtatgt tgggttctat cgacgctaac      900

agaggtgact accaaaacgg ttgggacact gaccaattcc caatcgacca atacgaattg      960

gttcaagctt ggatggaaat catcagaggt ggtggtttca ctactggtgg tactaacttc     1020

gacgctaaga ctagaagaaa ctctactgac ttggaagaca tcatcatcgc tcacatctct     1080

ggtatggacg ctatggctag agctttggaa aacgctgcta agttgttgac tgaatctcca     1140

tacaagaaga tgaaggctga cagatacgct tctttcgact ctggtatggg taaggacttc     1200

gaagacggta agttgacttt cgaacaagtt tacgaatacg gtaagaaggt taacgaacca     1260

aagcaaactt ctggtaagca agaattgtac gaagctatcg ttgctatgta catgtga        1317


<210>  9
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Directed Chimeric Xylose Isomerase 2

<400>  9

Met Lys Leu Thr Val Gly Asp Lys Glu Tyr Phe Lys Gly Ile Lys Pro 
1               5                   10                  15      


Ile Lys Phe Glu Gly Lys Asp Ser Lys Asn Val Met Ala Phe His Tyr 
            20                  25                  30          


Tyr Glu Pro Glu Lys Val Val Met Gly Lys Lys Met Lys Asp Trp Leu 
        35                  40                  45              


Lys Phe Ala Met Ala Trp Trp His Thr Leu Gly Gly Ala Ser Ala Asp 
    50                  55                  60                  


Gln Phe Gly Gly Gln Thr Arg Ser Tyr Glu Trp Asp Lys Ala Ala Asp 
65                  70                  75                  80  


Ala Val Gln Arg Ala Lys Asp Lys Met Asp Ala Gly Phe Glu Ile Met 
                85                  90                  95      


Asp Lys Leu Gly Ile Glu Tyr Phe Cys Phe His Asp Val Asp Leu Val 
            100                 105                 110         


Glu Glu Gly Glu Thr Ile Ala Glu Tyr Glu Arg Arg Met Lys Glu Ile 
        115                 120                 125             


Thr Asp Tyr Ala Leu Val Lys Met Lys Glu Tyr Pro Asn Ile Lys Leu 
    130                 135                 140                 


Leu Trp Gly Thr Ala Asn Val Phe Gly Asn Lys Arg Tyr Ala Asn Gly 
145                 150                 155                 160 


Ala Ser Thr Asn Pro Asp Phe Asp Val Val Ala Arg Ala Ile Val Gln 
                165                 170                 175     


Ile Lys Asn Ala Ile Asp Ala Thr Ile Lys Leu Gly Gly Thr Asn Tyr 
            180                 185                 190         


Val Phe Trp Gly Gly Arg Glu Gly Tyr Met Thr Leu Leu Asn Thr Asp 
        195                 200                 205             


Met Lys Arg Glu Gln Glu His Leu Ala Arg Phe Leu Thr Met Ala Lys 
    210                 215                 220                 


Asp Tyr Ala Arg Lys Gln Gly Phe Thr Gly Thr Phe Phe Ile Glu Pro 
225                 230                 235                 240 


Lys Pro Cys Glu Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr 
                245                 250                 255     


Val Ile Gly Phe Leu Arg His Phe Gly Leu Asp Lys Asp Phe Lys Leu 
            260                 265                 270         


Asn Leu Glu Val Asn His Ala Thr Leu Ala Gly His Thr Phe Glu His 
        275                 280                 285             


Glu Leu Ala Cys Ala Val Asp Ala Gly Met Leu Gly Ser Ile Asp Ala 
    290                 295                 300                 


Asn Arg Gly Asp Tyr Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Ile 
305                 310                 315                 320 


Asp Gln Tyr Glu Leu Val Gln Ala Trp Met Glu Ile Ile Arg Gly Gly 
                325                 330                 335     


Gly Phe Thr Thr Gly Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn 
            340                 345                 350         


Ser Thr Asp Leu Glu Asp Ile Ile Ile Ala His Ile Ser Gly Met Asp 
        355                 360                 365             


Ala Met Ala Arg Ala Leu Glu Asn Ala Ala Lys Leu Leu Thr Glu Ser 
    370                 375                 380                 


Pro Tyr Lys Lys Met Lys Ala Asp Arg Tyr Ala Ser Phe Asp Ser Gly 
385                 390                 395                 400 


Met Gly Lys Asp Phe Glu Asp Gly Lys Leu Thr Phe Glu Gln Val Tyr 
                405                 410                 415     


Glu Tyr Gly Lys Lys Val Asn Glu Pro Lys Gln Thr Ser Gly Lys Gln 
            420                 425                 430         


Glu Leu Tyr Glu Ala Ile Val Ala Met Tyr Met 
        435                 440             


<210>  10
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Directed Chimeric Xylose Isomerase 2

<400>  10
atgaagttga ccgttggtga caaagaatac ttcaagggta ttaagccaat caagttcgaa       60

ggtaaggact ctaagaacgt tatggctttc cactactacg aaccagaaaa ggttgttatg      120

ggtaagaaga tgaaggactg gttgaagttc gctatggctt ggtggcacac tttgggtggt      180

gcttctgctg accaattcgg tggtcaaact agatcttacg aatgggacaa ggctgctgac      240

gctgttcaaa gagctaagga caagatggac gctggtttcg aaatcatgga caagttgggt      300

atcgaatact tctgtttcca cgacgttgac ttggttgaag aaggtgaaac tatcgctgaa      360

tacgaaagaa gaatgaagga aatcactgac tacgctttgg ttaagatgaa ggaataccca      420

aacatcaagt tgttgtgggg tactgctaac gttttcggta acaagagata cgctaacggt      480

gcttctacta acccagactt cgacgttgtt gctagagcta tcgttcaaat caagaacgct      540

atcgacgcta ctatcaagtt gggtggtact aactacgttt tctggggtgg tagagaaggt      600

tacatgactt tgttgaacac cgacatgaag agagaacaag aacatttggc tagattcttg      660

accatggcta aagattacgc tagaaagcaa ggtttcaccg gtactttttt cattgaacct      720

aagccatgcg aacctaccaa acatcaatat gattacgatg ctgccaccgt tattggtttt      780

ttgagacatt tcggtttgga caaggacttc aagttgaact tggaagttaa ccatgctact      840

ttggctggtc acactttcga acacgaattg gcttgtgctg ttgacgctgg tatgttgggt      900

tctatcgacg ctaacagagg tgactaccaa aacggttggg acactgacca attcccaatc      960

gaccaatacg aattggttca agcttggatg gaaatcatca gaggtggtgg tttcactact     1020

ggtggtacta acttcgacgc taagactaga agaaactcta ctgacttgga agacatcatc     1080

atcgctcaca tctctggtat ggacgctatg gctagagctt tggaaaacgc tgctaagttg     1140

ttgactgaat ctccatacaa gaagatgaag gctgacagat acgcttcttt cgactctggt     1200

atgggtaagg acttcgaaga cggtaagttg actttcgaac aagtttacga atacggtaag     1260

aaggttaacg aaccaaagca aacttctggt aagcaagaat tgtacgaagc tatcgttgct     1320

atgtacatgt ga                                                         1332


<210>  11
<211>  438
<212>  PRT
<213>  Bacteroides thetaiotaomicron

<400>  11

Met Ala Thr Lys Glu Phe Phe Pro Gly Ile Glu Lys Ile Lys Phe Glu 
1               5                   10                  15      


Gly Lys Asp Ser Lys Asn Pro Met Ala Phe Arg Tyr Tyr Asp Ala Glu 
            20                  25                  30          


Lys Val Ile Asn Gly Lys Lys Met Lys Asp Trp Leu Arg Phe Ala Met 
        35                  40                  45              


Ala Trp Trp His Thr Leu Cys Ala Glu Gly Gly Asp Gln Phe Gly Gly 
    50                  55                  60                  


Gly Thr Lys Gln Phe Pro Trp Asn Gly Asn Ala Asp Ala Ile Gln Ala 
65                  70                  75                  80  


Ala Lys Asp Lys Met Asp Ala Gly Phe Glu Phe Met Gln Lys Met Gly 
                85                  90                  95      


Ile Glu Tyr Tyr Cys Phe His Asp Val Asp Leu Val Ser Glu Gly Ala 
            100                 105                 110         


Ser Val Glu Glu Tyr Glu Ala Asn Leu Lys Glu Ile Val Ala Tyr Ala 
        115                 120                 125             


Lys Gln Lys Gln Ala Glu Thr Gly Ile Lys Leu Leu Trp Gly Thr Ala 
    130                 135                 140                 


Asn Val Phe Gly His Ala Arg Tyr Met Asn Gly Ala Ala Thr Asn Pro 
145                 150                 155                 160 


Asp Phe Asp Val Val Ala Arg Ala Ala Val Gln Ile Lys Asn Ala Ile 
                165                 170                 175     


Asp Ala Thr Ile Glu Leu Gly Gly Glu Asn Tyr Val Phe Trp Gly Gly 
            180                 185                 190         


Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asp Gln Lys Arg Glu Lys 
        195                 200                 205             


Glu His Leu Ala Gln Met Leu Thr Ile Ala Arg Asp Tyr Ala Arg Ala 
    210                 215                 220                 


Arg Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro 
225                 230                 235                 240 


Thr Lys His Gln Tyr Asp Val Asp Thr Glu Thr Val Ile Gly Phe Leu 
                245                 250                 255     


Lys Ala His Gly Leu Asp Lys Asp Phe Lys Val Asn Ile Glu Val Asn 
            260                 265                 270         


His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Ala Val Ala 
        275                 280                 285             


Val Asp Asn Gly Met Leu Gly Ser Ile Asp Ala Asn Arg Gly Asp Tyr 
    290                 295                 300                 


Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Ile Asp Asn Tyr Glu Leu 
305                 310                 315                 320 


Thr Gln Ala Met Met Gln Ile Ile Arg Asn Gly Gly Leu Gly Thr Gly 
                325                 330                 335     


Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu 
            340                 345                 350         


Asp Ile Phe Ile Ala His Ile Ala Gly Met Asp Ala Met Ala Arg Ala 
        355                 360                 365             


Leu Glu Ser Ala Ala Ala Leu Leu Asp Glu Ser Pro Tyr Lys Lys Met 
    370                 375                 380                 


Leu Ala Asp Arg Tyr Ala Ser Phe Asp Gly Gly Lys Gly Lys Glu Phe 
385                 390                 395                 400 


Glu Asp Gly Lys Leu Thr Leu Glu Asp Val Val Ala Tyr Ala Lys Thr 
                405                 410                 415     


Lys Gly Glu Pro Lys Gln Thr Ser Gly Lys Gln Glu Leu Tyr Glu Ala 
            420                 425                 430         


Ile Leu Asn Met Tyr Cys 
        435             


<210>  12
<211>  1317
<212>  DNA
<213>  Bacteroides thetaiotaomicron

<400>  12
atggcaacaa aagaattttt tccgggaatt gaaaagatta aatttgaagg taaagatagt       60

aagaacccga tggcattccg ttattacgat gcagagaagg tgattaatgg taaaaagatg      120

aaggattggc tgagattcgc tatggcatgg tggcacacat tgtgcgctga aggtggtgat      180

cagttcggtg gcggaacaaa gcaattccca tggaatggta atgcagatgc tatacaggca      240

gcaaaagata agatggatgc aggatttgaa ttcatgcaga agatgggtat cgaatactat      300

tgcttccatg acgtagactt ggtttcggaa ggtgccagtg tagaagaata cgaagctaac      360

ctgaaagaaa tcgtagctta tgcaaaacag aaacaggcag aaaccggtat caaactactg      420

tggggtactg ctaatgtatt cggtcacgcc cgctatatga acggtgcagc taccaatcct      480

gacttcgatg tagtagctcg tgctgctgtt cagatcaaaa atgcgattga tgcaacgatt      540

gaacttggcg gagagaatta tgtgttttgg ggtggtcgtg aaggctatat gtctcttctg      600

aacacagatc agaaacgtga aaaagaacac cttgcacaga tgttgacgat tgctcgtgac      660

tatgcccgtg cccgtggttt caaaggtact ttcctgatcg aaccgaaacc gatggaaccg      720

actaaacatc aatatgacgt agatacggaa actgtaatcg gcttcctgaa agctcatggt      780

ctggataagg atttcaaagt aaatatcgag gtgaatcacg caactttggc aggtcacact      840

ttcgagcatg aattggctgt agctgtagac aatggtatgt tgggctcaat tgacgccaat      900

cgtggtgact atcagaatgg ctgggataca gaccaattcc cgatcgacaa ttatgaactg      960

actcaggcta tgatgcagat tatccgtaat ggtggtctcg gtaccggtgg tacgaacttt     1020

gatgctaaaa cccgtcgtaa ttctactgat ctggaagata tctttattgc tcacatcgca     1080

ggtatggacg ctatggcccg tgcactcgaa agtgcagcgg ctctgctcga cgaatctccc     1140

tataagaaga tgctggctga ccgttatgct tcatttgatg ggggcaaagg taaagaattt     1200

gaagacggca agctgactct ggaggatgtg gttgcttatg caaaaacaaa aggcgaaccg     1260

aaacagacta gcggcaagca agaactttat gaggcaattc tgaatatgta ttgctaa        1317


<210>  13
<211>  442
<212>  PRT
<213>  Parabacteroides distasonis

<400>  13

Met Ser Tyr Phe Lys Gly Glu Lys Glu Phe Phe Pro Gly Ile Gly Gln 
1               5                   10                  15      


Ile Gln Phe Glu Gly Arg Glu Ser Lys Asn Pro Leu Ala Phe His Tyr 
            20                  25                  30          


Tyr Asp Ala Asp Lys Val Val Met Gly Lys Thr Leu Lys Asp His Leu 
        35                  40                  45              


Arg Phe Ala Met Ala Tyr Trp His Thr Leu Cys Ala Glu Gly Gly Asp 
    50                  55                  60                  


Gln Phe Gly Gly Gly Thr Lys Thr Phe Pro Trp Asn Asp Ser Thr Asp 
65                  70                  75                  80  


Ala Ile Thr Arg Ala Lys Tyr Lys Met Asp Ala Ala Phe Glu Phe Met 
                85                  90                  95      


Thr Lys Cys Asn Ile Pro Tyr Tyr Cys Phe His Asp Val Asp Val Val 
            100                 105                 110         


Asp Glu Ala Pro Thr Leu Gly Glu Phe Glu Lys Arg Leu Gln Thr Met 
        115                 120                 125             


Val Glu His Ala Lys Glu His Gln Ala Ala Thr Gly Lys Lys Leu Leu 
    130                 135                 140                 


Trp Ser Thr Ala Asn Val Phe Gly His Lys Arg Tyr Met Asn Gly Ala 
145                 150                 155                 160 


Ala Thr Asn Pro Tyr Phe Pro Thr Val Ala Cys Val Gly Thr Gln Ile 
                165                 170                 175     


Lys Asn Ala Ile Asp Ala Cys Ile Ala Leu Gly Gly Glu Asn Tyr Val 
            180                 185                 190         


Phe Trp Gly Gly Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asn Met 
        195                 200                 205             


Lys Arg Glu Lys Asp His Leu Ala Met Met Leu Thr Met Ala Arg Asp 
    210                 215                 220                 


Tyr Gly Arg Lys Asn Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys 
225                 230                 235                 240 


Pro Met Glu Pro Thr Lys His Gln Tyr Asp Val Asp Ser Glu Thr Val 
                245                 250                 255     


Ile Gly Phe Leu Arg His Tyr Gly Leu Asp Lys Asp Phe Ala Leu Asn 
            260                 265                 270         


Ile Glu Val Asn His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu 
        275                 280                 285             


Leu Gln Ala Ala Ala Asp Ala Gly Met Leu Cys Ser Ile Asp Ala Asn 
    290                 295                 300                 


Arg Gly Asp Tyr Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Met Asp 
305                 310                 315                 320 


Ile Tyr Glu Leu Ala Gln Ala Trp Leu Val Ile Leu Glu Gly Gly Gly 
                325                 330                 335     


Leu Thr Thr Gly Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser 
            340                 345                 350         


Thr Asp Leu Glu Asp Ile Phe Ile Ala His Ile Gly Gly Met Asp Ala 
        355                 360                 365             


Phe Ala Arg Ala Leu Met Ile Ala Ala Asp Ile Leu Glu Asn Ser Asp 
    370                 375                 380                 


Tyr Arg Lys Met Arg Ala Glu Arg Tyr Ala Ser Phe Asp Ala Gly Glu 
385                 390                 395                 400 


Gly Lys Ala Phe Glu Asp Gly Lys Leu Thr Leu Glu Asp Leu Arg Thr 
                405                 410                 415     


Ile Ala Leu Arg Asp Gly Glu Pro Lys Gln Ile Ser Gly Lys Gln Glu 
            420                 425                 430         


Leu Tyr Glu Met Ile Val Asn Leu His Ile 
        435                 440         


<210>  14
<211>  1329
<212>  DNA
<213>  Parabacteroides_distasonis

<400>  14
atgtcttact ttaagggtga aaaagaattc ttcccaggta tcggtcaaat ccaatttgaa       60

ggtagagaat ccaagaaccc attggctttt cattattacg atgccgataa ggttgtcatg      120

ggtaaaactt tgaaggacca tttgagattc gctatggctt attggcatac tttgtgtgct      180

gaaggtggtg atcaatttgg tggtggtaca aaaactttcc catggaatga ttccaccgat      240

gctattacta gagccaagta caaaatggat gctgcttttg aattcatgac caagtgcaac      300

attccttact actgcttcca cgatgttgat gttgttgatg aagctccaac tttgggtgaa      360

ttcgaaaaaa gattgcaaac catggtcgaa catgccaaag aacatcaagc tgctactggt      420

aaaaagttgt tgtggtctac tgctaatgtt ttcggtcaca agagatatat gaacggtgct      480

gctactaatc catactttcc aactgttgct tgcgttggta ctcaaatcaa gaatgctatt      540

gatgcttgca ttgctttggg tggtgaaaat tatgttttct ggggtggtag agaaggttac      600

atgtctttgt tgaacaccaa catgaagaga gaaaaggatc atttggccat gatgttgact      660

atggctagag attacggtag aaagaatggt ttcaagggta ctttcttgat cgaacctaaa      720

cctatggaac ctactaagca ccaatacgat gttgattccg aaaccgttat cggtttcttg      780

agacattacg gtttggataa ggatttcgcc ttgaacatcg aagttaacca tgctactttg      840

gctggtcata ctttcgaaca tgaattgcaa gctgctgctg atgctggtat gttgtgttct      900

attgatgcta acagaggtga ctaccaaaat ggttgggata ctgatcaatt cccaatggat      960

atctacgaat tggctcaagc ttggttggtt attttggaag gtggtggttt gactactggt     1020

ggtactaatt ttgatgccaa gaccagaaga aactccactg atttggaaga catcttcatt     1080

gcccatatcg gtggtatgga tgcttttgct agagctttga tgattgctgc cgatattttg     1140

gaaaactccg actacagaaa gatgagagct gaaagatacg cttcttttga tgctggtgaa     1200

ggtaaggctt tcgaagatgg taaattgacc ttggaagatt tgagaaccat tgctttgaga     1260

gatggtgaac ctaagcaaat ttccggtaag caagaattat acgaaatgat cgtcaacttg     1320

cacatctaa                                                             1329


<210>  15
<211>  437
<212>  PRT
<213>  Cyllamyces aberensis

<400>  15

Met Val Lys Glu Tyr Phe Pro Ala Ile Gln Lys Ile Lys Phe Glu Gly 
1               5                   10                  15      


Lys Asp Ser Lys Asn Pro Met Ala Phe His Tyr Tyr Asp Ala Glu Lys 
            20                  25                  30          


Glu Ile Met Gly Lys Lys Met Lys Asp Trp Leu Arg Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Cys Ala Glu Gly Ser Asp Gln Phe Gly Pro Gly 
    50                  55                  60                  


Thr Lys Thr Phe Pro Trp Asn Glu Gly Thr Asp Pro Ile Glu Lys Ala 
65                  70                  75                  80  


Lys Gln Lys Val Asp Ala Gly Phe Glu Ile Met Thr Lys Leu Gly Ile 
                85                  90                  95      


Glu His Tyr Cys Phe His Asp Val Asp Leu Val Asp Glu Gly Lys Asn 
            100                 105                 110         


Val Glu Glu Tyr Glu Lys Asn Leu Lys Thr Ile Val Ala Tyr Leu Lys 
        115                 120                 125             


Glu Lys Gln Lys Glu Thr Gly Ile Lys Leu Leu Trp Ser Thr Ala Asn 
    130                 135                 140                 


Val Phe Gly His Lys Arg Tyr Met Asn Gly Ala Ser Thr Asn Pro Asp 
145                 150                 155                 160 


Phe Asp Val Val Ala Arg Ala Ile Val Gln Ile Lys Asn Ala Met Asp 
                165                 170                 175     


Ala Gly Ile Glu Leu Gly Ala Glu Asn Tyr Val Phe Trp Gly Gly Arg 
            180                 185                 190         


Glu Gly Tyr Met Ser Leu Leu Asn Thr Asp Gln Lys Arg Glu Lys Glu 
        195                 200                 205             


His Met Ala Met Met Leu Gly Leu Ala Arg Asp Tyr Ala Arg Ser Lys 
    210                 215                 220                 


Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro Thr 
225                 230                 235                 240 


Lys His Gln Tyr Asp Val Asp Thr Glu Thr Val Ile Gly Phe Leu Arg 
                245                 250                 255     


Ala His Gly Leu Asp Lys Asp Phe Lys Ile Asn Ile Glu Val Asn His 
            260                 265                 270         


Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Ala Cys Ala Val 
        275                 280                 285             


Asp Ala Gly Met Leu Gly Ser Ile Asp Ala Asn Arg Gly Asp Tyr Gln 
    290                 295                 300                 


Asn Gly Trp Asp Thr Asp Gln Phe Pro Ile Asp Gln Tyr Glu Leu Val 
305                 310                 315                 320 


Gln Ala Trp Met Glu Ile Ile Arg Gly Gly Gly Phe Thr Thr Gly Gly 
                325                 330                 335     


Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu Asp 
            340                 345                 350         


Ile Ile Ile Ala His Ile Ser Gly Met Asp Ala Met Ala Arg Ala Leu 
        355                 360                 365             


Glu Asn Ala Ala Lys Leu Leu Thr Glu Ser Pro Tyr Lys Lys Met Lys 
    370                 375                 380                 


Ala Asp Arg Tyr Ala Ser Phe Asp Ser Gly Met Gly Lys Asp Phe Glu 
385                 390                 395                 400 


Asp Gly Lys Leu Thr Phe Glu Gln Val Tyr Glu Tyr Gly Lys Lys Val 
                405                 410                 415     


Asn Glu Pro Lys Gln Thr Ser Gly Lys Gln Glu Leu Tyr Glu Ala Ile 
            420                 425                 430         


Val Ala Met Tyr Met 
        435         


<210>  16
<211>  1314
<212>  DNA
<213>  Cyllamyces_aberensis

<400>  16
atggttaagg aatacttccc agctatccaa aagatcaagt tcgaaggtaa ggactctaag       60

aacccaatgg ctttccacta ctacgacgct gaaaaggaaa tcatgggtaa gaagatgaag      120

gactggttga gattcgctat ggcttggtgg cacactttgt gtgctgaagg ttctgaccaa      180

ttcggtccag gtactaagac tttcccatgg aacgaaggta ctgacccaat cgaaaaggct      240

aagcaaaagg ttgacgctgg tttcgaaatc atgactaagt tgggtatcga acactactgt      300

ttccacgacg ttgacttggt tgacgaaggt aagaacgttg aagaatacga aaagaacttg      360

aagactatcg ttgcttactt gaaggaaaag caaaaggaaa ctggtatcaa gttgttgtgg      420

tctactgcta acgttttcgg tcacaagaga tacatgaacg gtgcttctac taacccagac      480

ttcgacgttg ttgctagagc tatcgttcaa atcaagaacg ctatggacgc tggtatcgaa      540

ttgggtgctg aaaactacgt tttctggggt ggtagagaag gttacatgtc tttgttgaac      600

actgaccaaa agagagaaaa ggaacacatg gctatgatgt tgggtttggc tagagactac      660

gctagatcta agggtttcaa gggtactttc ttgatcgaac caaagccaat ggaaccaact      720

aagcaccaat acgacgttga cactgaaact gttatcggtt tcttgagagc tcacggtttg      780

gacaaggact tcaagatcaa catcgaagtt aaccacgcta ctttggctgg tcacactttc      840

gaacacgaat tggcttgtgc tgttgacgct ggtatgttgg gttctatcga cgctaacaga      900

ggtgactacc aaaacggttg ggacactgac caattcccaa tcgaccaata cgaattggtt      960

caagcttgga tggaaatcat cagaggtggt ggtttcacta ctggtggtac taacttcgac     1020

gctaagacta gaagaaactc tactgacttg gaagacatca tcatcgctca catctctggt     1080

atggacgcta tggctagagc tttggaaaac gctgctaagt tgttgactga atctccatac     1140

aagaagatga aggctgacag atacgcttct ttcgactctg gtatgggtaa ggacttcgaa     1200

gacggtaagt tgactttcga acaagtttac gaatacggta agaaggttaa cgaaccaaag     1260

caaacttctg gtaagcaaga attgtacgaa gctatcgttg ctatgtacat gtga           1314


<210>  17
<211>  440
<212>  PRT
<213>  Abiotrophia defectiva

<400>  17

Met Ser Glu Leu Phe Gln Asn Ile Pro Lys Ile Lys Tyr Glu Gly Ala 
1               5                   10                  15      


Asn Ser Lys Asn Pro Leu Ala Phe His Tyr Tyr Asp Ala Glu Lys Ile 
            20                  25                  30          


Val Leu Gly Lys Thr Met Lys Glu His Leu Pro Phe Ala Met Ala Trp 
        35                  40                  45              


Trp His Asn Leu Cys Ala Ala Gly Thr Asp Met Phe Gly Arg Asp Thr 
    50                  55                  60                  


Ala Asp Lys Ser Phe Gly Leu Glu Lys Gly Ser Met Glu His Ala Lys 
65                  70                  75                  80  


Ala Lys Val Asp Ala Gly Phe Glu Phe Met Glu Lys Leu Gly Ile Lys 
                85                  90                  95      


Tyr Phe Cys Phe His Asp Val Asp Leu Val Pro Glu Ala Cys Asp Ile 
            100                 105                 110         


Lys Glu Thr Asn Ser Arg Leu Asp Glu Ile Ser Asp Tyr Ile Leu Glu 
        115                 120                 125             


Lys Met Lys Gly Thr Asp Ile Lys Cys Leu Trp Gly Thr Ala Asn Met 
    130                 135                 140                 


Phe Ser Asn Pro Arg Phe Val Asn Gly Ala Gly Ser Thr Asn Ser Ala 
145                 150                 155                 160 


Asp Val Tyr Cys Phe Ala Ala Ala Gln Ile Lys Lys Ala Leu Asp Ile 
                165                 170                 175     


Thr Val Lys Leu Gly Gly Arg Gly Tyr Val Phe Trp Gly Gly Arg Glu 
            180                 185                 190         


Gly Tyr Glu Thr Leu Leu Asn Thr Asp Val Lys Phe Glu Gln Glu Asn 
        195                 200                 205             


Ile Ala Asn Leu Met Lys Met Ala Val Glu Tyr Gly Arg Ser Ile Gly 
    210                 215                 220                 


Phe Lys Gly Asp Phe Tyr Ile Glu Pro Lys Pro Lys Glu Pro Met Lys 
225                 230                 235                 240 


His Gln Tyr Asp Phe Asp Ala Ala Thr Ala Ile Gly Phe Leu Arg Gln 
                245                 250                 255     


Tyr Gly Leu Asp Lys Asp Phe Lys Leu Asn Ile Glu Ala Asn His Ala 
            260                 265                 270         


Thr Leu Ala Gly His Ser Phe Gln His Glu Leu Arg Ile Ser Ser Ile 
        275                 280                 285             


Asn Gly Met Leu Gly Ser Val Asp Ala Asn Gln Gly Asp Met Leu Leu 
    290                 295                 300                 


Gly Trp Asp Thr Asp Glu Phe Pro Phe Asp Val Tyr Asp Thr Thr Met 
305                 310                 315                 320 


Cys Met Tyr Glu Val Leu Lys Asn Gly Gly Leu Thr Gly Gly Phe Asn 
                325                 330                 335     


Phe Asp Ala Lys Asn Arg Arg Pro Ser Tyr Thr Tyr Glu Asp Met Phe 
            340                 345                 350         


Tyr Gly Phe Ile Leu Gly Met Asp Ser Phe Ala Leu Gly Leu Ile Lys 
        355                 360                 365             


Ala Ala Lys Leu Ile Glu Glu Gly Thr Leu Asp Asn Phe Ile Lys Glu 
    370                 375                 380                 


Arg Tyr Lys Ser Phe Glu Ser Glu Ile Gly Lys Lys Ile Arg Ser Lys 
385                 390                 395                 400 


Ser Ala Ser Leu Gln Glu Leu Ala Ala Tyr Ala Glu Glu Met Gly Ala 
                405                 410                 415     


Pro Ala Met Pro Gly Ser Gly Arg Gln Glu Tyr Leu Gln Ala Ala Leu 
            420                 425                 430         


Asn Gln Asn Leu Phe Gly Glu Val 
        435                 440 


<210>  18
<211>  1323
<212>  DNA
<213>  Abiotrophia defectiva

<400>  18
atgtctgaat tgttccaaaa catcccaaag atcaagtacg aaggtgctaa ctctaagaac       60

ccattggctt tccactacta cgacgctgaa aagatcgttt tgggtaagac tatgaaggaa      120

cacttgccat tcgctatggc ttggtggcac aacttgtgtg ctgctggtac tgacatgttc      180

ggtagagaca ctgctgacaa gtctttcggt ttggaaaagg gttctatgga acacgctaag      240

gctaaggttg acgctggttt cgaattcatg gaaaagttgg gtatcaagta cttctgtttc      300

cacgacgttg acttggttcc agaagcttgt gacatcaagg aaactaactc tagattggac      360

gaaatctctg actacatctt ggaaaagatg aagggtactg acatcaagtg tttgtggggt      420

actgctaaca tgttctctaa cccaagattc gttaacggtg ctggttctac taactctgct      480

gacgtttact gtttcgctgc tgctcaaatc aagaaggctt tggacatcac tgttaagttg      540

ggtggtagag gttacgtttt ctggggtggt agagaaggtt acgaaacttt gttgaacact      600

gacgttaagt tcgaacaaga aaacatcgct aacttgatga agatggctgt tgaatacggt      660

agatctatcg gtttcaaggg tgacttctac atcgaaccaa agccaaagga accaatgaag      720

caccaatacg acttcgacgc tgctactgct atcggtttct tgagacaata cggtttggac      780

aaggacttca agttgaacat cgaagctaac cacgctactt tggctggtca ctctttccaa      840

cacgaattga gaatctcttc tatcaacggt atgttgggtt ctgttgacgc taaccaaggt      900

gacatgttgt tgggttggga cactgacgaa ttcccattcg acgtttacga cactactatg      960

tgtatgtacg aagttttgaa gaacggtggt ttgactggtg gtttcaactt cgacgctaag     1020

aacagaagac catcttacac ttacgaagac atgttctacg gtttcatctt gggtatggac     1080

tctttcgctt tgggtttgat caaggctgct aagttgatcg aagaaggtac tttggacaac     1140

ttcatcaagg aaagatacaa gtctttcgaa tctgaaatcg gtaagaagat cagatctaag     1200

tctgcttctt tgcaagaatt ggctgcttac gctgaagaaa tgggtgctcc agctatgcca     1260

ggttctggta gacaagaata cttgcaagct gctttgaacc aaaacttgtt cggtgaagtt     1320

tga                                                                   1323


<210>  19
<211>  442
<212>  PRT
<213>  Uncultured bacterium XYM2

<400>  19

Met Lys Leu Thr Val Gly Asp Lys Glu Tyr Phe Lys Gly Ile Lys Pro 
1               5                   10                  15      


Ile Lys Phe Glu Gly Lys Asp Ser Asp Asn Pro Leu Ala Phe Lys Tyr 
            20                  25                  30          


Tyr Asn Pro Ser Gln Lys Val Gly Lys Lys Thr Met Glu Glu His Phe 
        35                  40                  45              


Arg Phe Ala Ile Ala Tyr Trp His Thr Phe Cys Gly Thr Gly Gly Asp 
    50                  55                  60                  


Pro Phe Gly Pro Gly Thr Lys Thr Phe Pro Trp Leu Gln Asn Ser Asp 
65                  70                  75                  80  


Ala Val Gln Arg Ala Tyr Asp Lys Met Asp Ala Ala Phe Glu Phe Ile 
                85                  90                  95      


Thr Lys Ile Gly Ala Pro Phe Tyr Cys Phe His Asp Tyr Asp Leu Val 
            100                 105                 110         


Asp Glu Gly Pro Thr Leu Lys Glu Ser Glu Ser Arg Leu Gln Lys Val 
        115                 120                 125             


Val Asp Tyr Ala Lys Lys Lys Gln Lys Ala Ser Gly Val Lys Leu Leu 
    130                 135                 140                 


Trp Gly Thr Ala Asn Leu Phe Ser His Pro Arg Tyr Met Asn Gly Ala 
145                 150                 155                 160 


Ala Thr Asn Pro Asp Phe Asp Val Val Cys Tyr Ala Ala Ser Gln Val 
                165                 170                 175     


Lys Asn Ala Leu Asp Ala Thr Ile Ala Leu Gly Gly Ala Asn Tyr Val 
            180                 185                 190         


Phe Trp Gly Gly Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asn Met 
        195                 200                 205             


Lys Arg Glu Gln Glu His Met Ala Lys Phe Leu His Met Ala Lys Asp 
    210                 215                 220                 


Tyr Ala Arg Ala Asn Gly Phe Lys Gly Thr Phe Phe Ile Glu Pro Lys 
225                 230                 235                 240 


Pro Met Glu Pro Ser Lys His Gln Tyr Asp Phe Asp Ser Ala Thr Val 
                245                 250                 255     


Ile Gly Phe Leu Arg Gln Phe Asp Leu Leu Gly Asp Phe Lys Leu Asn 
            260                 265                 270         


Ile Glu Val Asn His Ala Thr Leu Ala His His Thr Phe Gln His Glu 
        275                 280                 285             


Leu Gln Val Ala Ala Asp Ala Gly Ala Leu Gly Ser Ile Asp Ala Asn 
    290                 295                 300                 


Arg Gly Asp Tyr Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Asn Asn 
305                 310                 315                 320 


Leu Tyr Glu Leu Ala Glu Ser Met Leu Val Ile Leu Glu Ala Gly Gly 
                325                 330                 335     


Phe Lys Ser Gly Gly Val Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser 
            340                 345                 350         


Thr Asp Leu Val Asp Ile Phe His Ala His Ile Gly Gly Met Asp Thr 
        355                 360                 365             


Phe Ala Arg Ser Leu Leu Ile Ala Gln Ala Val Leu Asp Asn Gly Glu 
    370                 375                 380                 


Tyr Thr Lys Ile Arg Lys Asp Arg Tyr Ser Ser Phe Asp Ser Gly Lys 
385                 390                 395                 400 


Gly Lys Gln Phe Asp Gln Gly Lys Leu Ser Leu Glu Asp Leu Arg Asn 
                405                 410                 415     


Leu Ala His Lys Ala Gly Glu Pro Lys Gln Leu Ser Gly Lys Gln Glu 
            420                 425                 430         


Tyr Ile Glu Asn Leu Ile Ser Arg Phe Ile 
        435                 440         


<210>  20
<211>  1329
<212>  DNA
<213>  Uncultured bacterium XYM2

<400>  20
atgaagttga ccgttggtga caaagaatac ttcaagggta ttaagccaat caagttcgaa       60

ggtaaggatt ccgataatcc attggctttc aagtactaca acccatctca aaaggttggt      120

aaaaagacca tggaagaaca tttcagattc gctattgctt actggcatac tttttgtggt      180

actggtggtg atccatttgg tccaggtaca aaaacttttc catggttgca aaactccgat      240

gctgttcaaa gagcttacga taagatggat gctgcctttg aattcattac caaaattggt      300

gctccattct actgcttcca tgattacgat ttggttgatg aaggtccaac cttgaaagaa      360

tccgaatcca gattgcaaaa ggtcgttgat tacgctaaga aaaagcaaaa agcctccggt      420

gttaagttgt tgtggggtac tgctaatttg ttctcccatc caagatatat gaatggtgct      480

gctacaaacc cagatttcga tgttgtttgt tatgctgcct ctcaagttaa gaatgctttg      540

gatgctacta ttgctttggg tggtgctaat tatgtttttt ggggtggtag agaaggttac      600

atgtctttgt tgaacaccaa catgaagaga gaacaagaac atatggctaa gttcttgcat      660

atggccaagg attatgctag agctaatggt tttaagggta ctttcttcat cgaacctaaa      720

cctatggaac catctaagca ccaatacgat tttgattccg ctaccgttat tggtttcttg      780

agacaatttg atttgttggg tgacttcaag ttgaacatcg aagttaacca tgctaccttg      840

gctcatcata cctttcaaca tgaattgcaa gttgctgctg atgctggtgc tttaggttct      900

attgatgcta atagaggtga ctaccaaaac ggttgggata ctgatcaatt tccaaacaac      960

ttgtacgaat tggccgaatc catgttggtt attttggaag ctggtggttt taaatccggt     1020

ggtgttaatt tcgatgctaa gaccagaaga aactctaccg atttggtcga tattttccat     1080

gctcatattg gtggtatgga tacctttgct agatccttgt tgattgctca agctgttttg     1140

gataatggtg aatacaccaa gatcagaaag gacagatact cctctttcga ttctggtaaa     1200

ggtaagcaat tcgatcaagg taaattgtcc ttggaagatt tgagaaactt ggctcacaaa     1260

gctggtgaac ctaagcaatt gtctggtaag caagaatata tcgaaaactt gatctccaga     1320

ttcatttga                                                             1329


<210>  21
<211>  442
<212>  PRT
<213>  Chitinophaga pinensis

<400>  21

Met Ser Ile Thr Leu Gly Asn Gln Glu Tyr Phe Lys Gly Ile Gly Lys 
1               5                   10                  15      


Ile Ala Tyr Glu Gly Pro Gln Ser Thr Asn Pro Phe Ala Tyr Lys Trp 
            20                  25                  30          


Tyr Asp Glu Asn Arg Lys Ile Gly Gly Lys Thr Met Lys Glu Leu Phe 
        35                  40                  45              


Arg Phe Ala Val Ser Tyr Trp His Thr Phe Cys Gly Thr Gly Gly Asp 
    50                  55                  60                  


Pro Phe Gly Pro Gly Thr Lys Ala Phe Pro Trp Leu Thr Ala Thr Asp 
65                  70                  75                  80  


Ala Val Gln Ser Ala Lys Asp Lys Met Asp Ala Ala Phe Glu Phe Phe 
                85                  90                  95      


Thr Lys Leu Gly Val Pro Tyr Tyr Cys Phe His Asp Val Asp Leu Val 
            100                 105                 110         


Asp Glu Gly Ala Ser Ile Ser Glu Tyr Glu Ser Arg Met Gln Gln Ile 
        115                 120                 125             


Val Glu Tyr Ala Lys Glu Lys Gln Lys Ala Ser Gly Val Lys Leu Leu 
    130                 135                 140                 


Trp Gly Thr Ala Asn Val Phe Ser Asn Pro Arg Tyr Met Asn Gly Ala 
145                 150                 155                 160 


Ala Thr Asn Pro Asp Phe Ala Ala Val Ala Tyr Ala Gly Thr Gln Val 
                165                 170                 175     


Lys Asn Ser Leu Asp Ala Thr Ile Ala Leu Gly Gly Glu Asn Tyr Val 
            180                 185                 190         


Phe Trp Gly Gly Arg Glu Gly Tyr Met Thr Leu Leu Asn Thr Asp Met 
        195                 200                 205             


Lys Arg Glu Gln Glu His Leu Ala Arg Phe Leu Thr Met Ala Lys Asp 
    210                 215                 220                 


Tyr Ala Arg Lys Gln Gly Phe Thr Gly Thr Phe Phe Ile Glu Pro Lys 
225                 230                 235                 240 


Pro Cys Glu Pro Thr Lys His Gln Tyr Asp Tyr Asp Ala Ala Thr Val 
                245                 250                 255     


Ile Gly Phe Leu Arg His Phe Gly Leu Asp Lys Asp Phe Lys Leu Asn 
            260                 265                 270         


Leu Glu Val Asn His Ala Thr Leu Ala Gly His Thr Phe Gln His Glu 
        275                 280                 285             


Leu Gln Val Ala Ala Asp Ala Gly Met Leu Gly Ser Ile Asp Ala Asn 
    290                 295                 300                 


Arg Gly Asp Ala Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Met Asn 
305                 310                 315                 320 


Leu Asn Asp Met Val Glu Phe Met Leu Val Ile Leu Glu Ala Gly Gly 
                325                 330                 335     


Phe Ser Gly Gly Gly Val Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser 
            340                 345                 350         


Thr Asp Leu Glu Asp Ile Phe His Ala His Ile Gly Gly Ile Asp Ser 
        355                 360                 365             


Phe Ala Arg Ala Ala Val Ile Ala Glu Lys Val Leu Glu Gln Ser Pro 
    370                 375                 380                 


Tyr Lys Gln Phe Arg Lys Asp Arg Tyr Ala Ser Phe Asp Ser Gly Lys 
385                 390                 395                 400 


Gly Lys Asp Phe Glu Ala Gly Thr Leu Thr Leu Glu Asp Leu Arg Ser 
                405                 410                 415     


Phe Ala Val Ser Asn Gly Glu Pro Lys His Ile Ser Gly Lys Gln Glu 
            420                 425                 430         


Trp Leu Glu Asn Ile Ile Asn Gln Tyr Ile 
        435                 440         


<210>  22
<211>  1329
<212>  DNA
<213>  Chitinophaga pinensis

<400>  22
atgtccatca ccttgggtaa tcaagaatac ttcaagggta ttggtaagat tgcttacgaa       60

ggtccacaat ctactaatcc atttgcttac aagtggtacg acgaaaacag aaaaattggt      120

ggtaagacca tgaaggaatt attcagattc gctgtttcct actggcatac tttttgtggt      180

actggtggtg atccatttgg tccaggtaca aaagcttttc catggttgac tgctactgat      240

gctgttcaat ctgctaagga taagatggat gctgcttttg aattcttcac caaattgggt      300

gttccttact actgcttcca cgatgttgat ttggttgatg aaggtgcttc catttctgaa      360

tacgaatcca gaatgcaaca aatcgtcgaa tacgccaaag aaaagcaaaa agcttccggt      420

gttaagttgt tgtggggtac tgctaatgtt ttctccaacc caagatatat gaacggtgct      480

gctactaatc cagattttgc tgctgttgct tatgctggta ctcaagttaa gaactctttg      540

gatgctacca ttgctttggg tggtgaaaat tatgttttct ggggtggtag agaaggttac      600

atgactttgt tgaacaccga catgaagaga gaacaagaac atttggctag attcttgacc      660

atggctaaag attacgctag aaagcaaggt ttcaccggta cttttttcat tgaacctaag      720

ccatgcgaac ctaccaaaca tcaatatgat tacgatgctg ccaccgttat tggttttttg      780

agacatttcg gtttggacaa ggacttcaag ttgaacttgg aagttaacca tgctactttg      840

gctggtcata ctttccaaca cgaattgcaa gttgctgctg atgctggtat gttgggttct      900

attgatgcta atagaggtga tgctcaaaac ggttgggata ctgatcaatt tccaatgaac      960

ttgaacgaca tggtcgaatt catgttggtt attttggaag ctggtggttt ttctggtggt     1020

ggtgttaatt ttgatgccaa gactagaaga aactccaccg atttggaaga tattttccat     1080

gctcatatcg gtggtattga ttcttttgct agagctgctg ttatcgctga aaaggttttg     1140

gaacaatccc catacaagca attcagaaag gatagatacg cttctttcga ttctggtaag     1200

ggtaaggatt ttgaagctgg tactttgacc ttggaagatt tgagatcttt cgctgtttct     1260

aacggtgaac ctaaacatat ttccggtaag caagaatggt tggaaaacat catcaatcag     1320

tatatctaa                                                             1329


<210>  23
<211>  439
<212>  PRT
<213>  Prevotella ruminicola

<400>  23

Met Ala Lys Glu Tyr Phe Pro Phe Thr Gly Lys Ile Pro Phe Glu Gly 
1               5                   10                  15      


Lys Asp Ser Lys Asn Val Met Ala Phe His Tyr Tyr Glu Pro Glu Lys 
            20                  25                  30          


Val Val Met Gly Lys Lys Met Lys Asp Trp Leu Lys Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Gly Gly Ala Ser Ala Asp Gln Phe Gly Gly Gln 
    50                  55                  60                  


Thr Arg Ser Tyr Glu Trp Asp Lys Ala Ala Asp Ala Val Gln Arg Ala 
65                  70                  75                  80  


Lys Asp Lys Met Asp Ala Gly Phe Glu Ile Met Asp Lys Leu Gly Ile 
                85                  90                  95      


Glu Tyr Phe Cys Phe His Asp Val Asp Leu Val Glu Glu Gly Glu Thr 
            100                 105                 110         


Ile Ala Glu Tyr Glu Arg Arg Met Lys Glu Ile Thr Asp Tyr Ala Leu 
        115                 120                 125             


Val Lys Met Lys Glu Tyr Pro Asn Ile Lys Leu Leu Trp Gly Thr Ala 
    130                 135                 140                 


Asn Val Phe Gly Asn Lys Arg Tyr Ala Asn Gly Ala Ser Thr Asn Pro 
145                 150                 155                 160 


Asp Phe Asp Val Val Ala Arg Ala Ile Val Gln Ile Lys Asn Ala Ile 
                165                 170                 175     


Asp Ala Thr Ile Lys Leu Gly Gly Thr Asn Tyr Val Phe Trp Gly Gly 
            180                 185                 190         


Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asp Gln Lys Arg Glu Lys 
        195                 200                 205             


Glu His Met Ala Thr Met Leu Thr Met Ala Arg Asp Tyr Ala Arg Ala 
    210                 215                 220                 


Lys Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro 
225                 230                 235                 240 


Ser Lys His Gln Tyr Asp Val Asp Thr Glu Thr Val Cys Gly Phe Leu 
                245                 250                 255     


Arg Ala His Gly Leu Asp Lys Asp Phe Lys Val Asn Ile Glu Val Asn 
            260                 265                 270         


His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Ala Cys Ala 
        275                 280                 285             


Val Asp Asn Gly Met Leu Gly Ser Ile Asp Ala Asn Arg Gly Asp Ala 
    290                 295                 300                 


Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Ile Asp Asn Phe Glu Leu 
305                 310                 315                 320 


Thr Gln Ala Met Leu Glu Ile Ile Arg Asn Gly Gly Leu Gly Asn Gly 
                325                 330                 335     


Gly Thr Asn Phe Asp Ala Lys Ile Arg Arg Asn Ser Thr Asp Leu Glu 
            340                 345                 350         


Asp Leu Phe Ile Ala His Ile Ser Gly Met Asp Ala Met Ala Arg Ala 
        355                 360                 365             


Leu Met Asn Ala Ala Ala Ile Leu Glu Glu Ser Glu Leu Pro Lys Met 
    370                 375                 380                 


Lys Lys Glu Arg Tyr Ala Ser Phe Asp Asn Gly Ile Gly Lys Asp Phe 
385                 390                 395                 400 


Glu Asp Gly Lys Leu Thr Leu Glu Gln Ala Tyr Glu Tyr Gly Lys Lys 
                405                 410                 415     


Val Glu Glu Pro Lys Gln Thr Ser Gly Lys Gln Glu Lys Tyr Glu Thr 
            420                 425                 430         


Thr Val Ala Leu Tyr Cys Lys 
        435                 


<210>  24
<211>  1320
<212>  DNA
<213>  Prevotella ruminicola

<400>  24
atggctaagg aatacttccc attcactggt aagatcccat tcgaaggtaa ggactctaag       60

aacgttatgg ctttccacta ctacgaacca gaaaaggttg ttatgggtaa gaagatgaag      120

gactggttga agttcgctat ggcttggtgg cacactttgg gtggtgcttc tgctgaccaa      180

ttcggtggtc aaactagatc ttacgaatgg gacaaggctg ctgacgctgt tcaaagagct      240

aaggacaaga tggacgctgg tttcgaaatc atggacaagt tgggtatcga atacttctgt      300

ttccacgacg ttgacttggt tgaagaaggt gaaactatcg ctgaatacga aagaagaatg      360

aaggaaatca ctgactacgc tttggttaag atgaaggaat acccaaacat caagttgttg      420

tggggtactg ctaacgtttt cggtaacaag agatacgcta acggtgcttc tactaaccca      480

gacttcgacg ttgttgctag agctatcgtt caaatcaaga acgctatcga cgctactatc      540

aagttgggtg gtactaacta cgttttctgg ggtggtagag aaggttacat gtctttgttg      600

aacactgacc aaaagagaga aaaggaacac atggctacta tgttgactat ggctagagac      660

tacgctagag ctaagggttt caagggtact ttcttgatcg aaccaaagcc aatggaacca      720

tctaagcacc aatacgacgt tgacactgaa actgtttgtg gtttcttgag agctcacggt      780

ttggacaagg acttcaaggt taacatcgaa gttaaccacg ctactttggc tggtcacact      840

ttcgaacacg aattggcttg tgctgttgac aacggtatgt tgggttctat cgacgctaac      900

agaggtgacg ctcaaaacgg ttgggacact gaccaattcc caatcgacaa cttcgaattg      960

actcaagcta tgttggaaat catcagaaac ggtggtttgg gtaacggtgg tactaacttc     1020

gacgctaaga tcagaagaaa ctctactgac ttggaagact tgttcatcgc tcacatctct     1080

ggtatggacg ctatggctag agctttgatg aacgctgctg ctatcttgga agaatctgaa     1140

ttgccaaaga tgaagaagga aagatacgct tctttcgaca acggtatcgg taaggacttc     1200

gaagacggta agttgacttt ggaacaagct tacgaatacg gtaagaaggt tgaagaacca     1260

aagcaaactt ctggtaagca agaaaagtac gaaactactg ttgctttgta ctgtaagtga     1320


<210>  25
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX386 chimeric xylose isomerase

<400>  25

Met Ala Lys Glu Tyr Phe Pro Phe Thr Gly Lys Ile Pro Phe Glu Gly 
1               5                   10                  15      


Lys Asp Ser Lys Asn Val Met Ala Phe His Tyr Tyr Glu Pro Glu Lys 
            20                  25                  30          


Val Val Met Gly Lys Lys Met Lys Asp Trp Leu Lys Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Gly Gly Ala Ser Ala Asp Gln Phe Gly Gly Gln 
    50                  55                  60                  


Thr Arg Ser Tyr Glu Trp Asp Lys Ala Ala Asp Ala Val Gln Arg Ala 
65                  70                  75                  80  


Lys Asp Lys Met Asp Ala Gly Phe Glu Ile Met Asp Lys Leu Gly Ile 
                85                  90                  95      


Glu Tyr Phe Cys Phe His Asp Val Asp Leu Val Glu Glu Gly Glu Thr 
            100                 105                 110         


Ile Ala Glu Tyr Glu Arg Arg Met Lys Glu Ile Thr Asp Tyr Ala Leu 
        115                 120                 125             


Val Lys Met Lys Glu Tyr Pro Asn Ile Lys Leu Leu Trp Gly Thr Ala 
    130                 135                 140                 


Asn Val Phe Ser Asn Pro Arg Tyr Met Asn Gly Ala Ala Thr Asn Pro 
145                 150                 155                 160 


Asp Phe Ala Ala Val Ala Tyr Ala Gly Thr Gln Val Lys Asn Ser Leu 
                165                 170                 175     


Asp Ala Thr Ile Ala Leu Gly Gly Glu Asn Tyr Val Phe Trp Gly Gly 
            180                 185                 190         


Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asn Met Lys Arg Glu Lys 
        195                 200                 205             


Asp His Leu Ala Met Met Leu Thr Met Ala Arg Asp Tyr Gly Arg Lys 
    210                 215                 220                 


Asn Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro 
225                 230                 235                 240 


Thr Lys His Gln Tyr Asp Val Asp Ser Glu Thr Val Ile Gly Phe Leu 
                245                 250                 255     


Arg His Tyr Gly Leu Asp Lys Asp Phe Ala Leu Asn Ile Glu Val Asn 
            260                 265                 270         


His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Gln Ala Ala 
        275                 280                 285             


Ala Asp Ala Gly Met Leu Cys Ser Ile Asp Ala Asn Arg Gly Asp Tyr 
    290                 295                 300                 


Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Met Asp Ile Tyr Glu Leu 
305                 310                 315                 320 


Ala Gln Ala Trp Leu Val Ile Leu Glu Gly Gly Gly Leu Thr Thr Gly 
                325                 330                 335     


Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu 
            340                 345                 350         


Asp Ile Phe Ile Ala His Ile Gly Gly Met Asp Ala Phe Ala Arg Ala 
        355                 360                 365             


Leu Met Ile Ala Ala Asp Ile Leu Glu Asn Ser Asp Tyr Arg Lys Met 
    370                 375                 380                 


Arg Ala Glu Arg Tyr Ala Ser Phe Asp Ala Gly Glu Gly Lys Ala Phe 
385                 390                 395                 400 


Glu Asp Gly Lys Leu Thr Leu Glu Asp Leu Arg Thr Ile Ala Leu Arg 
                405                 410                 415     


Asp Gly Glu Pro Lys Gln Ile Ser Gly Lys Gln Glu Leu Tyr Glu Met 
            420                 425                 430         


Ile Val Asn Leu His Ile 
        435             


<210>  26
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CX386 chimeric xylose isomerase

<400>  26
atggctaagg aatacttccc attcactggt aagatcccat tcgaaggtaa ggactctaag       60

aacgttatgg ctttccacta ctacgaacca gaaaaggttg ttatgggtaa gaagatgaag      120

gactggttga agttcgctat ggcttggtgg cacactttgg gtggtgcttc tgctgaccaa      180

ttcggtggtc aaactagatc ttacgaatgg gacaaggctg ctgacgctgt tcaaagagct      240

aaggacaaga tggacgctgg tttcgaaatc atggacaagt tgggtatcga atacttctgt      300

ttccacgacg ttgacttggt tgaagaaggt gaaactatcg ctgaatacga aagaagaatg      360

aaggaaatca ctgactacgc tttggttaag atgaaggaat acccaaacat caagttgttg      420

tggggtactg ctaatgtttt ctccaaccca agatatatga acggtgctgc tactaatcca      480

gattttgctg ctgttgctta tgctggtact caagttaaga actctttgga tgctaccatt      540

gctttgggtg gtgaaaatta tgttttctgg ggtggtagag aaggttacat gtctttgttg      600

aacaccaaca tgaagagaga aaaggatcat ttggccatga tgttgactat ggctagagat      660

tacggtagaa agaatggttt caagggtact ttcttgatcg aacctaaacc tatggaacct      720

actaagcacc aatacgatgt tgattccgaa accgttatcg gtttcttgag acattacggt      780

ttggataagg atttcgcctt gaacatcgaa gttaaccatg ctactttggc tggtcatact      840

ttcgaacatg aattgcaagc tgctgctgat gctggtatgt tgtgttctat tgatgctaac      900

agaggtgact accaaaatgg ttgggatact gatcaattcc caatggatat ctacgaattg      960

gctcaagctt ggttggttat tttggaaggt ggtggtttga ctactggtgg tactaatttt     1020

gatgccaaga ccagaagaaa ctccactgat ttggaagaca tcttcattgc ccatatcggt     1080

ggtatggatg cttttgctag agctttgatg attgctgccg atattttgga aaactccgac     1140

tacagaaaga tgagagctga aagatacgct tcttttgatg ctggtgaagg taaggctttc     1200

gaagatggta aattgacctt ggaagatttg agaaccattg ctttgagaga tggtgaacct     1260

aagcaaattt ccggtaagca agaattatac gaaatgatcg tcaacttgca catctaa        1317


<210>  27
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX1224 chimeric xylose isomerase

<400>  27

Met Thr Lys Glu Tyr Phe Pro Phe Thr Gly Lys Ile Pro Tyr Glu Gly 
1               5                   10                  15      


Lys Asp Ser Asn Asn Val Met Ala Phe His Tyr Tyr Glu Pro Glu Lys 
            20                  25                  30          


Val Val Met Gly Lys Lys Met Lys Asp Trp Leu Lys Phe Ala Met Ala 
        35                  40                  45              


Trp Trp His Thr Leu Gly Gly Ala Ser Ala Asp Gln Phe Gly Gly Gln 
    50                  55                  60                  


Thr Arg Ser Tyr Glu Trp Asp Lys Ala Ala Asp Ala Val Gln Arg Ala 
65                  70                  75                  80  


Lys Asp Lys Met Asp Ala Gly Phe Glu Ile Met Asp Lys Leu Gly Ile 
                85                  90                  95      


Glu Tyr Phe Cys Phe His Asp Val Asp Leu Val Glu Glu Gly Glu Thr 
            100                 105                 110         


Ile Ala Glu Tyr Glu Arg Arg Met Lys Glu Ile Thr Asp Tyr Ala Leu 
        115                 120                 125             


Val Lys Met Lys Glu Tyr Pro Asn Ile Lys Leu Leu Trp Gly Thr Ala 
    130                 135                 140                 


Asn Val Phe Ser Asn Pro Arg Tyr Met Asn Gly Ala Ala Thr Asn Pro 
145                 150                 155                 160 


Asp Phe Ala Ala Val Ala Tyr Ala Gly Thr Gln Val Lys Asn Ser Leu 
                165                 170                 175     


Asp Ala Thr Ile Ala Leu Gly Gly Glu Asn Tyr Val Phe Trp Gly Gly 
            180                 185                 190         


Arg Glu Gly Tyr Met Ser Leu Leu Asn Thr Asn Met Lys Arg Glu Lys 
        195                 200                 205             


Asp His Leu Ala Met Met Leu Thr Met Ala Arg Asp Tyr Gly Arg Lys 
    210                 215                 220                 


Asn Gly Phe Lys Gly Thr Phe Leu Ile Glu Pro Lys Pro Met Glu Pro 
225                 230                 235                 240 


Thr Lys His Gln Tyr Asp Val Asp Ser Glu Thr Val Ile Gly Phe Leu 
                245                 250                 255     


Arg His Tyr Gly Leu Asp Lys Asp Phe Ala Leu Asn Ile Glu Val Asn 
            260                 265                 270         


His Ala Thr Leu Ala Gly His Thr Phe Glu His Glu Leu Gln Ala Ala 
        275                 280                 285             


Ala Asp Ala Gly Met Leu Cys Ser Ile Asp Ala Asn Arg Gly Asp Tyr 
    290                 295                 300                 


Gln Asn Gly Trp Asp Thr Asp Gln Phe Pro Met Asp Ile Tyr Glu Leu 
305                 310                 315                 320 


Ala Gln Ala Trp Leu Val Ile Leu Glu Asn Gly Gly Leu Thr Thr Gly 
                325                 330                 335     


Gly Thr Asn Phe Asp Ala Lys Thr Arg Arg Asn Ser Thr Asp Leu Glu 
            340                 345                 350         


Asp Ile Phe Ile Ala His Ile Gly Gly Met Asp Ala Phe Ala Arg Ala 
        355                 360                 365             


Leu Met Ile Ala Ala Asp Ile Leu Glu Asn Ser Asp Tyr Arg Lys Met 
    370                 375                 380                 


Arg Ala Glu Arg Tyr Gly Thr Phe Asp Ala Gly Glu Gly Lys Ala Phe 
385                 390                 395                 400 


Glu Glu Gly Gln Leu Thr Leu Glu Asp Leu Arg Thr Ile Ala Leu Arg 
                405                 410                 415     


Asp Gly Asp Pro Lys Lys Ile Ser Gly Lys Gln Glu Leu Tyr Glu Met 
            420                 425                 430         


Ile Val Asn Leu His Ile 
        435             


<210>  28
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CX1224 chimeric xylose isomerase

<400>  28
atgactaagg aatacttccc attcactggt aagatcccat acgaaggtaa ggactctaat       60

aacgttatgg ctttccacta ctacgaacca gaaaaggttg ttatgggtaa gaagatgaag      120

gactggttga agttcgctat ggcttggtgg cacactttgg gtggtgcttc tgctgaccaa      180

ttcggtggtc aaactagatc ttacgaatgg gacaaggctg ctgacgctgt tcaaagagct      240

aaggacaaga tggacgctgg tttcgaaatc atggacaagt tgggtatcga atacttctgt      300

ttccacgacg ttgacttggt tgaagaaggt gaaactatcg ctgaatacga aagaagaatg      360

aaggaaatca ctgactacgc tttggttaag atgaaggaat acccaaacat caagttgttg      420

tggggtactg ctaatgtttt ctccaaccca agatatatga acggtgctgc tactaatcca      480

gattttgctg ctgttgctta tgctggtact caagttaaga actctttgga tgctaccatt      540

gctttgggtg gtgaaaatta tgttttctgg ggtggtagag aaggttacat gtctttgttg      600

aacaccaaca tgaagagaga aaaggatcat ttggccatga tgttgactat ggctagagat      660

tacggtagaa agaatggttt caagggtact ttcttgatcg aacctaaacc tatggaacct      720

actaagcacc aatacgatgt tgattccgaa accgttatcg gtttcttgag acattacggt      780

ttggataagg atttcgcctt gaacatcgaa gttaaccatg ctactttggc tggtcatact      840

ttcgaacatg aattgcaagc tgctgctgat gctggtatgt tgtgttctat tgatgctaac      900

agaggtgact accaaaatgg ttgggatact gatcaattcc caatggatat ctacgaattg      960

gctcaagctt ggttggttat tttggaaaac ggtggtttga ctactggtgg tactaatttt     1020

gatgccaaga ccagaagaaa ctccactgat ttggaagaca tcttcattgc ccatatcggt     1080

ggtatggatg cttttgctag agctttgatg attgctgccg atattttgga aaactccgac     1140

tacagaaaga tgagagctga aagatacggt acttttgatg ctggtgaagg taaggctttc     1200

gaagaaggtc aattgacctt ggaagatttg agaaccattg ctttgagaga tggtgatcct     1260

aagaagattt ccggtaagca agaattatac gaaatgatcg tcaacttgca catctaa        1317


