﻿               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

<120> Prevention of tumour metastasis by inhibition of necroptosis

<130> X1810 PCT

<150> EP14180878.2
<151> 2014-08-13

<160> 8

<170> BiSSAP 1.3

<210> 1
<211> 2016
<212> DNA
<213> Homo sapiens

<220> 
<223> human RIPK1

<400> 1
atgcaaccag acatgtcctt gaatgtcatt aagatgaaat ccagtgactt cctggagagt      60

gcagaactgg acagcggagg ctttgggaag gtgtctctgt gtttccacag aacccaggga     120

ctcatgatca tgaaaacagt gtacaagggg cccaactgca ttgagcacaa cgaggccctc     180

ttggaggagg cgaagatgat gaacagactg agacacagcc gggtggtgaa gctcctgggc     240

gtcatcatag aggaagggaa gtactccctg gtgatggagt acatggagaa gggcaacctg     300

atgcacgtgc tgaaagccga gatgagtact ccgctttctg taaaaggaag gataattttg     360

gaaatcattg aaggaatgtg ctacttacat ggaaaaggcg tgatacacaa ggacctgaag     420

cctgaaaata tccttgttga taatgacttc cacattaaga tcgcagacct cggccttgcc     480

tcctttaaga tgtggagcaa actgaataat gaagagcaca atgagctgag ggaagtggac     540

ggcaccgcta agaagaatgg cggcaccctc tactacatgg cgcccgagca cctgaatgac     600

gtcaacgcaa agcccacaga gaagtcggat gtgtacagct ttgctgtagt actctgggcg     660

atatttgcaa ataaggagcc atatgaaaat gctatctgtg agcagcagtt gataatgtgc     720

ataaaatctg ggaacaggcc agatgtggat gacatcactg agtactgccc aagagaaatt     780

atcagtctca tgaagctctg ctgggaagcg aatccggaag ctcggccgac atttcctggc     840

attgaagaaa aatttaggcc tttttattta agtcaattag aagaaagtgt agaagaggac     900

gtgaagagtt taaagaaaga gtattcaaac gaaaatgcag ttgtgaagag aatgcagtct     960

cttcaacttg attgtgtggc agtaccttca agccggtcaa attcagccac agaacagcct    1020

ggttcactgc acagttccca gggacttggg atgggtcctg tggaggagtc ctggtttgct    1080

ccttccctgg agcacccaca agaagagaat gagcccagcc tgcagagtaa actccaagac    1140

gaagccaact accatcttta tggcagccgc atggacaggc agacgaaaca gcagcccaga    1200

cagaatgtgg cttacaacag agaggaggaa aggagacgca gggtctccca tgaccctttt    1260

gcacagcaaa gaccttacga gaattttcag aatacagagg gaaaaggcac tgcttattcc    1320

agtgcagcca gtcatggtaa tgcagtgcac cagccctcag ggctcaccag ccaacctcaa    1380

gtactgtatc agaacaatgg attatatagc tcacatggct ttggaacaag accactggat    1440

ccaggaacag caggtcccag agtttggtac aggccaattc caagtcatat gcctagtctg    1500

cataatatcc cagtgcctga gaccaactat ctaggaaata cacccaccat gccattcagc    1560

tccttgccac caacagatga atctataaaa tataccatat acaatagtac tggcattcag    1620

attggagcct acaattatat ggagattggt gggacgagtt catcactact agacagcaca    1680

aatacgaact tcaaagaaga gccagctgct aagtaccaag ctatctttga taataccact    1740

agtctgacgg ataaacacct ggacccaatc agggaaaatc tgggaaagca ctggaaaaac    1800

tgtgcccgta aactgggctt cacacagtct cagattgatg aaattgacca tgactatgag    1860

cgagatggac tgaaagaaaa ggtttaccag atgctccaaa agtgggtgat gagggaaggc    1920

ataaagggag ccacggtggg gaagctggcc caggcgctcc accagtgttc caggatcgac    1980

cttctgagca gcttgattta cgtcagccag aactaa                              2016


<210> 2
<211> 671
<212> PRT
<213> Homo sapiens

<220> 
<223> human RIPK1

<400> 2
Met Gln Pro Asp Met Ser Leu Asn Val Ile Lys Met Lys Ser Ser Asp 
1               5                   10                  15      
Phe Leu Glu Ser Ala Glu Leu Asp Ser Gly Gly Phe Gly Lys Val Ser 
            20                  25                  30          
Leu Cys Phe His Arg Thr Gln Gly Leu Met Ile Met Lys Thr Val Tyr 
        35                  40                  45              
Lys Gly Pro Asn Cys Ile Glu His Asn Glu Ala Leu Leu Glu Glu Ala 
    50                  55                  60                  
Lys Met Met Asn Arg Leu Arg His Ser Arg Val Val Lys Leu Leu Gly 
65                  70                  75                  80  
Val Ile Ile Glu Glu Gly Lys Tyr Ser Leu Val Met Glu Tyr Met Glu 
                85                  90                  95      
Lys Gly Asn Leu Met His Val Leu Lys Ala Glu Met Ser Thr Pro Leu 
            100                 105                 110         
Ser Val Lys Gly Arg Ile Ile Leu Glu Ile Ile Glu Gly Met Cys Tyr 
        115                 120                 125             
Leu His Gly Lys Gly Val Ile His Lys Asp Leu Lys Pro Glu Asn Ile 
    130                 135                 140                 
Leu Val Asp Asn Asp Phe His Ile Lys Ile Ala Asp Leu Gly Leu Ala 
145                 150                 155                 160 
Ser Phe Lys Met Trp Ser Lys Leu Asn Asn Glu Glu His Asn Glu Leu 
                165                 170                 175     
Arg Glu Val Asp Gly Thr Ala Lys Lys Asn Gly Gly Thr Leu Tyr Tyr 
            180                 185                 190         
Met Ala Pro Glu His Leu Asn Asp Val Asn Ala Lys Pro Thr Glu Lys 
        195                 200                 205             
Ser Asp Val Tyr Ser Phe Ala Val Val Leu Trp Ala Ile Phe Ala Asn 
    210                 215                 220                 
Lys Glu Pro Tyr Glu Asn Ala Ile Cys Glu Gln Gln Leu Ile Met Cys 
225                 230                 235                 240 
Ile Lys Ser Gly Asn Arg Pro Asp Val Asp Asp Ile Thr Glu Tyr Cys 
                245                 250                 255     
Pro Arg Glu Ile Ile Ser Leu Met Lys Leu Cys Trp Glu Ala Asn Pro 
            260                 265                 270         
Glu Ala Arg Pro Thr Phe Pro Gly Ile Glu Glu Lys Phe Arg Pro Phe 
        275                 280                 285             
Tyr Leu Ser Gln Leu Glu Glu Ser Val Glu Glu Asp Val Lys Ser Leu 
    290                 295                 300                 
Lys Lys Glu Tyr Ser Asn Glu Asn Ala Val Val Lys Arg Met Gln Ser 
305                 310                 315                 320 
Leu Gln Leu Asp Cys Val Ala Val Pro Ser Ser Arg Ser Asn Ser Ala 
                325                 330                 335     
Thr Glu Gln Pro Gly Ser Leu His Ser Ser Gln Gly Leu Gly Met Gly 
            340                 345                 350         
Pro Val Glu Glu Ser Trp Phe Ala Pro Ser Leu Glu His Pro Gln Glu 
        355                 360                 365             
Glu Asn Glu Pro Ser Leu Gln Ser Lys Leu Gln Asp Glu Ala Asn Tyr 
    370                 375                 380                 
His Leu Tyr Gly Ser Arg Met Asp Arg Gln Thr Lys Gln Gln Pro Arg 
385                 390                 395                 400 
Gln Asn Val Ala Tyr Asn Arg Glu Glu Glu Arg Arg Arg Arg Val Ser 
                405                 410                 415     
His Asp Pro Phe Ala Gln Gln Arg Pro Tyr Glu Asn Phe Gln Asn Thr 
            420                 425                 430         
Glu Gly Lys Gly Thr Ala Tyr Ser Ser Ala Ala Ser His Gly Asn Ala 
        435                 440                 445             
Val His Gln Pro Ser Gly Leu Thr Ser Gln Pro Gln Val Leu Tyr Gln 
    450                 455                 460                 
Asn Asn Gly Leu Tyr Ser Ser His Gly Phe Gly Thr Arg Pro Leu Asp 
465                 470                 475                 480 
Pro Gly Thr Ala Gly Pro Arg Val Trp Tyr Arg Pro Ile Pro Ser His 
                485                 490                 495     
Met Pro Ser Leu His Asn Ile Pro Val Pro Glu Thr Asn Tyr Leu Gly 
            500                 505                 510         
Asn Thr Pro Thr Met Pro Phe Ser Ser Leu Pro Pro Thr Asp Glu Ser 
        515                 520                 525             
Ile Lys Tyr Thr Ile Tyr Asn Ser Thr Gly Ile Gln Ile Gly Ala Tyr 
    530                 535                 540                 
Asn Tyr Met Glu Ile Gly Gly Thr Ser Ser Ser Leu Leu Asp Ser Thr 
545                 550                 555                 560 
Asn Thr Asn Phe Lys Glu Glu Pro Ala Ala Lys Tyr Gln Ala Ile Phe 
                565                 570                 575     
Asp Asn Thr Thr Ser Leu Thr Asp Lys His Leu Asp Pro Ile Arg Glu 
            580                 585                 590         
Asn Leu Gly Lys His Trp Lys Asn Cys Ala Arg Lys Leu Gly Phe Thr 
        595                 600                 605             
Gln Ser Gln Ile Asp Glu Ile Asp His Asp Tyr Glu Arg Asp Gly Leu 
    610                 615                 620                 
Lys Glu Lys Val Tyr Gln Met Leu Gln Lys Trp Val Met Arg Glu Gly 
625                 630                 635                 640 
Ile Lys Gly Ala Thr Val Gly Lys Leu Ala Gln Ala Leu His Gln Cys 
                645                 650                 655     
Ser Arg Ile Asp Leu Leu Ser Ser Leu Ile Tyr Val Ser Gln Asn 
            660                 665                 670     

<210> 3
<211> 1557
<212> DNA
<213> Homo sapiens

<220> 
<223> human RIPK3

<400> 3
atgtcgtgcg tcaagttatg gcccagcggt gcccccgccc ccttggtgtc catcgaggaa      60

ctggagaacc aggagctcgt cggcaaaggc gggttcggca cagtgttccg ggcgcaacat     120

aggaagtggg gctacgatgt ggcggtcaag atcgtaaact cgaaggcgat atccagggag     180

gtcaaggcca tggcaagtct ggataacgaa ttcgtgctgc gcctagaagg ggttatcgag     240

aaggtgaact gggaccaaga tcccaagccg gctctggtga ctaaattcat ggagaacggc     300

tccttgtcgg ggctgctgca gtcccagtgc cctcggccct ggccgctcct ttgccgcctg     360

ctgaaagaag tggtgcttgg gatgttttac ctgcacgacc agaacccggt gctcctgcac     420

cgggacctca agccatccaa cgtcctgctg gacccagagc tgcacgtcaa gctggcagat     480

tttggcctgt ccacatttca gggaggctca cagtcaggga cagggtccgg ggagccaggg     540

ggcaccctgg gctacttggc cccagaactg tttgttaacg taaaccggaa ggcctccaca     600

gccagtgacg tctacagctt cgggatccta atgtgggcag tgcttgctgg aagagaagtt     660

gagttgccaa ccgaaccatc actcgtgtac gaagcagtgt gcaacaggca gaaccggcct     720

tcattggctg agctgcccca agccgggcct gagactcccg gcttagaagg actgaaggag     780

ctaatgcagc tctgctggag cagtgagccc aaggacagac cctccttcca ggaatgccta     840

ccaaaaactg atgaagtctt ccagatggtg gagaacaata tgaatgctgc tgtctccacg     900

gtaaaggatt tcctgtctca gctcaggagc agcaatagga gattttctat cccagagtca     960

ggccaaggag ggacagaaat ggatggcttt aggagaacca tagaaaacca gcactctcgt    1020

aatgatgtca tggtttctga gtggctaaac aaactgaatc tagaggagcc tcccagctct    1080

gttcctaaaa aatgcccgag ccttaccaag aggagcaggg cacaagagga gcaggttcca    1140

caagcctgga cagcaggcac atcttcagat tcgatggccc aacctcccca gactccagag    1200

acctcaactt tcagaaacca gatgcccagc cctacctcaa ctggaacacc aagtcctgga    1260

ccccgaggga atcagggggc tgagagacaa ggcatgaact ggtcctgcag gaccccggag    1320

ccaaatccag taacagggcg accgctcgtt aacatataca actgctctgg ggtgcaagtt    1380

ggagacaaca actacttgac tatgcaacag acaactgcct tgcccacatg gggcttggca    1440

ccttcgggca aggggagggg cttgcagcac cccccaccag taggttcgca agaaggccct    1500

aaagatcctg aagcctggag caggccacag ggttggtata atcatagcgg gaaataa       1557


<210> 4
<211> 518
<212> PRT
<213> Homo sapiens

<220> 
<223> human RIPK3

<400> 4
Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      
Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          
Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              
Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  
Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  
Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      
Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         
Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             
Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 
Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 
Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     
Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         
Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             
Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 
Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 
Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     
Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         
Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             
Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 
Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 
Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     
Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         
Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             
Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 
Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 
Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     
Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         
Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             
Leu Val Asn Ile Tyr Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn 
    450                 455                 460                 
Tyr Leu Thr Met Gln Gln Thr Thr Ala Leu Pro Thr Trp Gly Leu Ala 
465                 470                 475                 480 
Pro Ser Gly Lys Gly Arg Gly Leu Gln His Pro Pro Pro Val Gly Ser 
                485                 490                 495     
Gln Glu Gly Pro Lys Asp Pro Glu Ala Trp Ser Arg Pro Gln Gly Trp 
            500                 505                 510         
Tyr Asn His Ser Gly Lys 
        515             

<210> 5
<211> 1416
<212> DNA
<213> Homo sapiens

<220> 
<223> human MLKL ISOFORM 1

<400> 5
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag      60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag     120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca     180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc     240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac     300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa     360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat     420

gcagacgaag acaggcgagc tttccagatg ctaagaagag ataatgaaaa aatagaagct     480

tcactgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtattta     540

ccaccaaaat gcatgcagga gatcccgcaa gagcaaatca aggagatcaa gaaggagcag     600

ctttcaggat ccccgtggat tctgctaagg gaaaatgaag tcagcacact ttataaagga     660

gaataccaca gagctccagt ggccataaaa gtattcaaaa aactccaggc tggcagcatt     720

gcaatagtga ggcagacttt caataaggag atcaaaacca tgaagaaatt cgaatctccc     780

aacatcctgc gtatatttgg gatttgcatt gatgaaacag tgactccgcc tcaattctcc     840

attgtcatgg agtactgtga actcgggacc ctgagggagc tgttggatag ggaaaaagac     900

ctcacacttg gcaagcgcat ggtcctagtc ctgggggcag cccgaggcct ataccggcta     960

caccattcag aagcacctga actccacgga aaaatcagaa gctcaaactt cctggtaact    1020

caaggctacc aagtgaagct tgcaggattt gagttgagga aaacacagac ttccatgagt    1080

ttgggaacta cgagagaaaa gacagacaga gtcaaatcta cagcatatct ctcacctcag    1140

gaactggaag atgtatttta tcaatatgat gtaaagtctg aaatatacag ctttggaatc    1200

gtcctctggg aaatcgccac tggagatatc ccgtttcaag gctgtaattc tgagaagatc    1260

cgcaagctgg tggctgtgaa gcggcagcag gagccactgg gtgaagactg cccttcagag    1320

ctgcgggaga tcattgatga gtgccgggcc catgatccct ctgtgcggcc ctctgtggat    1380

gaaatcttaa agaaactctc caccttttct aagtag                              1416


<210> 6
<211> 471
<212> PRT
<213> Homo sapiens

<220> 
<223> human MLKL ISOFORM 1

<400> 6
Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      
Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          
His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              
Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  
Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  
Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      
Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         
Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             
Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 
Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 
Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     
Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         
Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             
Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 
Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 
Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     
Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         
Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             
Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 
Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 
His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     
Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         
Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             
Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 
Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 
Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     
Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         
Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             
Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 
Lys Leu Ser Thr Phe Ser Lys 
465                 470     

<210> 7
<211> 792
<212> DNA
<213> Homo sapiens

<220> 
<223> human MLKL ISOFORM 2

<400> 7
atggaaaatt tgaagcatat tatcaccctt ggccaggtca tccacaaacg gtgtgaagag      60

atgaaatact gcaagaaaca gtgccggcgc ctgggccacc gcgtcctcgg cctgatcaag     120

cctctggaga tgctccagga ccaaggaaag aggagcgtgc cctctgagaa gttaaccaca     180

gccatgaacc gcttcaaggc tgccctggag gaggctaatg gggagataga aaagttcagc     240

aatagatcca atatctgcag gtttctaaca gcaagccagg acaaaatact cttcaaggac     300

gtgaacagga agctgagtga tgtctggaag gagctctcgc tgttacttca ggttgagcaa     360

cgcatgcctg tttcacccat aagccaagga gcgtcctggg cacaggaaga tcagcaggat     420

gcagacgaag acaggcgagc tttccagatg ctaagaagag ataatgaaaa aatagaagct     480

tcactgagac gattagaaat caacatgaaa gaaatcaagg aaactttgag gcagtctttg     540

gaatcgtcct ctgggaaatc gccactggag atatcccgtt tcaaggtgaa gaatgtgaag     600

actggctcag ccagtggctg taattctgag aagatccgca agctggtggc tgtgaagcgg     660

cagcaggagc cactgggtga agactgccct tcagagctgc gggagatcat tgatgagtgc     720

cgggcccatg atccctctgt gcggccctct gtggatgaaa tcttaaagaa actctccacc     780

ttttctaagt ag                                                         792


<210> 8
<211> 262
<212> PRT
<213> Homo sapiens

<220> 
<223> human MLKL ISOFORM 2

<400> 8
Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      
Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          
His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              
Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  
Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  
Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      
Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         
Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             
Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 
Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 
Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     
Arg Gln Ser Leu Glu Ser Ser Ser Gly Lys Ser Pro Leu Glu Ile Ser 
            180                 185                 190         
Arg Phe Lys Val Lys Asn Val Lys Thr Gly Ser Ala Ser Gly Cys Asn 
        195                 200                 205             
Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
    210                 215                 220                 
Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
225                 230                 235                 240 
Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
                245                 250                 255     
Lys Leu Ser Thr Phe Ser 
            260         

