                         SEQUENCE LISTING

<110>  Miti Biosystems GmbH
 
<120>  CYCLIC PEPTIDES EXPRESSED BY A GENETIC PACKAGE

<130>  CH002P

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  1068
<212>  PRT
<213>  Prochlorococcus marinus

<400>  1

Met Glu Ser Pro Ser Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Asn 
65                  70                  75                  80  


Leu Asn Arg Pro Phe Val Asp Val Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ser Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Gly Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Cys Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asn 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Leu Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Leu Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Met Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Gly 
    450                 455                 460                 


Glu Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Glu Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Val Asn Gly Val Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln His Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile Arg Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu Pro Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ser Ser Ala Glu Thr Ser Leu Glu Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ser Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ala His Leu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Gln Gln Val Ser Leu Met Asp Ala Asp Ala Ile Gln 
                725                 730                 735     


Thr Ala Ile Leu Gln Pro Leu Val Gly Leu Val Asp Gln Pro Ser Asp 
            740                 745                 750         


Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly 
        755                 760                 765             


Cys Gly Gly Thr Leu Leu Ala Leu Thr Leu Gln Gly Glu Gln Ala Met 
    770                 775                 780                 


Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp 
785                 790                 795                 800 


Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu 
                805                 810                 815     


Val Gln Leu Gly Thr Glu Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly 
            820                 825                 830         


Asp His Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser 
        835                 840                 845             


Ser Ser Gln Pro Gly Leu Leu Gly Phe Ser His Gly Thr Ala Gly Tyr 
    850                 855                 860                 


Ala Ala Ala Leu Ala His Leu His Ala Phe Ser Ala Asp Glu Arg Tyr 
865                 870                 875                 880 


Arg Thr Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn 
                885                 890                 895     


Lys Asp Ala Gly Asn Trp Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser 
            900                 905                 910         


Asp Ser Asp Glu Pro Ser Phe Met Ala Ser Trp Cys His Gly Ala Pro 
        915                 920                 925             


Gly Ile Ala Leu Gly Arg Ala Cys Leu Trp Gly Thr Ala Leu Trp Asp 
    930                 935                 940                 


Glu Glu Cys Thr Lys Glu Ile Gly Ile Gly Leu Gln Thr Thr Ala Ala 
945                 950                 955                 960 


Val Ser Ser Val Ser Thr Asp His Leu Cys Cys Gly Ser Leu Gly Leu 
                965                 970                 975     


Met Val Leu Leu Glu Met Leu Ser Ala Gly Pro Trp Pro Ile Asp Asn 
            980                 985                 990         


Gln Leu Arg Ser His Cys Gln Asp  Val Ala Phe Gln Tyr  Arg Leu Gln 
        995                 1000                 1005             


Ala Leu  Gln Arg Cys Ser Ala  Glu Pro Ile Lys Leu  Arg Cys Phe 
    1010                 1015                 1020             


Gly Thr  Lys Glu Gly Leu Leu  Val Leu Pro Gly Phe  Phe Thr Gly 
    1025                 1030                 1035             


Leu Ser  Gly Met Gly Leu Ala  Leu Leu Glu Asp Asp  Pro Ser Arg 
    1040                 1045                 1050             


Ala Val  Val Ser Gln Leu Ile  Ser Ala Gly Leu Trp  Pro Thr Glu 
    1055                 1060                 1065             


<210>  2
<211>  1068
<212>  PRT
<213>  Prochlorococcus marinus

<400>  2

Met Thr Ser Pro Thr Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Ala Pro Thr Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Asp Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Thr 
65                  70                  75                  80  


Val Asn Arg Pro Phe Val Asp Leu Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ile Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Asp Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Gly Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Ala 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asp 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Phe Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Glu Pro Ser Thr Leu Gln Arg Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Gln Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Ile Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Ala Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Ala 
    450                 455                 460                 


Asp Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Lys Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Leu Asn Gly Ile Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Asn Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Ser Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Ala Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln Gln Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Ser Asn Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile His Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu His Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ala Ser Ala Glu Thr Ser Leu Lys Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ala Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ser His Leu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Gln Gln Val Pro Leu Met Asp Ala Asp Ala Ile Gln 
                725                 730                 735     


Thr Ala Ile Leu Gln Pro Leu Val Gly Leu Val Ala Gln Pro Ser Asp 
            740                 745                 750         


Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly 
        755                 760                 765             


Cys Gly Gly Thr Leu Leu Ala Leu Ala Leu Gln Gly Glu Gln Ala Met 
    770                 775                 780                 


Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp 
785                 790                 795                 800 


Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu 
                805                 810                 815     


Val Gln Leu Gly Thr Glu Ser Ala Leu Gln Trp Ala Leu Arg Ala Gly 
            820                 825                 830         


Asp His Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser 
        835                 840                 845             


Ser Ser Gln Pro Ala Leu Leu Gly Phe Ser His Gly Val Ala Gly Tyr 
    850                 855                 860                 


Ala Ala Ala Leu Ala His Leu His Ala Phe Ser Gly Asp Glu Arg Tyr 
865                 870                 875                 880 


Arg Ile Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn 
                885                 890                 895     


Lys Asp Ala Gly Asn Trp Pro Asp Tyr Arg Ser Ile Ser Arg Asp Ser 
            900                 905                 910         


Asp Ser Asp Glu Pro Ser Phe Met Ala Ser Trp Cys His Gly Ala Pro 
        915                 920                 925             


Gly Ile Ala Leu Gly Arg Ala Cys Leu Trp Gly Thr Ala Leu Trp Asp 
    930                 935                 940                 


Glu Glu Cys Thr Lys Glu Ile Gly Ile Gly Leu Gln Thr Thr Ala Ala 
945                 950                 955                 960 


Val Ser Ala Val Ser Thr Asp His Leu Cys Cys Gly Ser Leu Gly Leu 
                965                 970                 975     


Met Val Leu Leu Glu Met Leu Ser Lys Gly Pro Trp Pro Ile Asp Asn 
            980                 985                 990         


Gln Leu Arg Ser His Cys Gln Asp  Val Ala Ser Gln Tyr  Arg Leu Gln 
        995                 1000                 1005             


Ala Leu  Gln Arg Cys Ser Ala  Glu Pro Ile Lys Leu  Arg Cys Phe 
    1010                 1015                 1020             


Gly Thr  Lys Glu Gly Leu Leu  Val Leu Pro Gly Phe  Phe Thr Gly 
    1025                 1030                 1035             


Leu Ser  Gly Met Gly Leu Ala  Leu Leu Glu Asp Asp  Pro Ser Arg 
    1040                 1045                 1050             


Ala Val  Val Ser Gln Leu Ile  Ser Ala Gly Leu Trp  Pro Thr Glu 
    1055                 1060                 1065             


<210>  3
<211>  1058
<212>  PRT
<213>  Synechococcus sp.

<400>  3

Met Arg Glu Asn Trp Lys Gln Gln Trp Leu Asp Ile Val Ala Pro Asp 
1               5                   10                  15      


Glu Pro His Lys Leu Ser Arg Arg Leu Asp Trp Asp Glu Leu Thr Glu 
            20                  25                  30          


Glu Glu Phe Arg Glu His Leu Ser Thr Ser Pro Thr Lys Ala Asn Arg 
        35                  40                  45              


Phe Glu Gly His Trp Gln Asn Cys Leu Asn Glu Cys Arg Leu Ala Ile 
    50                  55                  60                  


Gln Lys Ala Trp Glu Gln Pro Leu Leu Pro Ile Ser Pro Asp Asn Gln 
65                  70                  75                  80  


Gln Arg Pro Phe Glu Asp Leu Trp Arg Pro Ile Cys Asn Glu Ala Arg 
                85                  90                  95      


Glu Ile Leu Lys Lys Arg Leu Ser Arg Leu Asp Gly Val Gly Glu Gly 
            100                 105                 110         


Ile Phe Glu Gln Leu Thr Asn Ser Leu Leu Asn Arg Leu Cys Ser Ile 
        115                 120                 125             


Gly Glu Gln Val Leu Trp Glu Lys Phe Asn Ser Glu Arg Ser Pro Gly 
    130                 135                 140                 


Val Met Leu Leu Ala His Leu Gly Ser Asn Gly Asp Gly Ser Gly Pro 
145                 150                 155                 160 


Pro Val Arg Glu Gly Tyr Glu Gln Phe Ile Arg Asn His Arg Gln Asp 
                165                 170                 175     


Gly Leu Thr Gln Leu Leu Gly Glu Phe Pro Glu Leu Gly Arg Leu Ile 
            180                 185                 190         


Gly Thr Ile Val Leu Leu Trp Leu Glu Gly Ser Gln Glu Met Leu Glu 
        195                 200                 205             


Arg Ile Asp Gln Asp Arg Gln Thr Leu Glu Thr Leu Phe Gly Ile Pro 
    210                 215                 220                 


Lys Asn Ala Pro Leu Gln Thr Ile His Gln Gly Leu Ser Asp Pro His 
225                 230                 235                 240 


Arg Gly Gly Arg Ala Val Ala Ile Leu Gly Phe Ala Gly Pro Gly Glu 
                245                 250                 255     


Glu Gln Tyr Lys Leu Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala 
            260                 265                 270         


Ala Tyr Gln Asp Leu Leu Lys Asp Ile Asn Arg Ser Ser Ser Asp Lys 
        275                 280                 285             


Pro Leu Lys Ile Leu Lys Ile His Asn Gly Glu Gly Tyr Gly Tyr Met 
    290                 295                 300                 


Glu Tyr Val Ser His Lys Pro Ala Arg Asp Asp Lys Glu Leu Gly Phe 
305                 310                 315                 320 


Phe Tyr Lys Asn Ala Gly Arg Leu Thr Ala Val Leu His Leu Leu Gly 
                325                 330                 335     


Cys Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu 
            340                 345                 350         


Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Glu Leu Pro Asn His 
        355                 360                 365             


Ile Asn Asn Asp Thr Ser Glu Ala Pro Glu Leu Ser Ala Leu Gln Lys 
    370                 375                 380                 


Arg Cys Gln Arg Ser Ile Leu Arg Ser Gly Leu Met Pro Gln Trp Met 
385                 390                 395                 400 


Phe Leu Gly Ser Glu Lys Ile Ala Ile Asp Ile Ser Ala Leu Gly Ile 
                405                 410                 415     


Ser Pro Pro Lys Gln Glu Thr Gln Lys Thr Ser Gly Trp Leu Gly Leu 
            420                 425                 430         


Asn Ser Asp Gly Met Met Pro Gly Val Ile Glu Arg Asn Ala Asp Leu 
        435                 440                 445             


Pro Thr Ser Leu Pro Ile Gly Ile Gly Ser Pro Asn Pro Phe Ser Leu 
    450                 455                 460                 


His Leu Asp Thr Phe Cys Glu Gly Phe Arg Glu Gln Asn Gln Thr Leu 
465                 470                 475                 480 


Ile Glu Gln Lys Asp Gln Trp Leu Lys Glu Gly Thr Phe Leu Asn Arg 
                485                 490                 495     


Phe Lys Gly Leu Arg Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr 
            500                 505                 510         


Phe Ala Ile Gln Arg Gln Gln Leu Glu Pro Ala Ala Leu Arg Ser Pro 
        515                 520                 525             


Leu Ile Gln Ala Ile Lys Leu Glu Gln Leu Ser Arg Ser Phe Leu Leu 
    530                 535                 540                 


Ala Glu Gln Lys Pro Leu His Trp Pro Val Phe Ala Ala Glu Leu Glu 
545                 550                 555                 560 


Gln Met Gln Gln Leu Asp Ile Pro Phe Phe Thr His Gln Ile Asp Ser 
                565                 570                 575     


Asp Ala Leu Asp Leu Asn Gln Ala Gln Thr Gln Leu Pro Gly Tyr Ile 
            580                 585                 590         


Glu Thr Ser Gly Leu Ser Ala Ala Lys Glu Arg Leu Glu Gln Leu Asp 
        595                 600                 605             


Thr Ser Glu Val Glu Phe Gln Ile Lys Leu Ile Arg Gly Thr Cys Asn 
    610                 615                 620                 


Ala Gln Lys Ile Arg Arg Gly Ala Ser Val Glu Thr Ser Val His Ser 
625                 630                 635                 640 


Ala Gln Glu Asn Gln Tyr Thr Thr Gln Thr Lys Ser Ala Ala Asp His 
                645                 650                 655     


Gln Val Ala Ala Thr Asn Val Met Asn Cys Leu Ala Asp Leu Ala Ile 
            660                 665                 670         


Glu Asp Asn Ser Gly Gln Met Glu Trp Leu Gly Met Asp Leu Gly Ala 
        675                 680                 685             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Phe Ser Leu Tyr Gly 
    690                 695                 700                 


Gly Ser Ser Gly Val Ala Ile Leu Asp His Thr Leu Gln Arg Leu Asn 
705                 710                 715                 720 


Gly Thr Asn Ser Gln Leu Ser Ala Ile Gln Ser Gly Val Leu Gln Ser 
                725                 730                 735     


Ile Gln Gln Leu Ala Glu Lys Ala Ser Glu Asp Gln Arg Leu Arg Trp 
            740                 745                 750         


Trp Arg Asp Gln Ser Leu Gly Leu Ser Gly Cys Gly Gly Met Leu Leu 
        755                 760                 765             


Thr Leu Gln Cys Leu Gly Gln Thr Ser Trp Ala Gln Ser Leu Leu Lys 
    770                 775                 780                 


Ser Gly Arg Gln Arg Phe Leu Glu Ala Asp Arg Gln Leu Asp Leu Ile 
785                 790                 795                 800 


Gly Gly Cys Thr Gly Leu Ile Gly Pro Leu Leu His Leu Lys Ser Pro 
                805                 810                 815     


Glu Ala Leu Asp Leu Ala Ile His Ala Gly Lys His Leu Leu Glu Gln 
            820                 825                 830         


Gln Gln Glu Asp Gly Ser Trp Pro Gly Arg Ala Lys Asn Thr Pro Gly 
        835                 840                 845             


Leu Leu Gly Phe Ser His Gly Thr Ala Gly His Ala Ala Ala Leu Ala 
    850                 855                 860                 


Lys Leu His Gln Ala Thr His Asp Asn Arg Phe Leu Glu Gly Ala Lys 
865                 870                 875                 880 


Ala Ala Leu His His Glu Arg Ala His Phe Asp Ser Lys Glu Glu Asn 
                885                 890                 895     


Trp Pro Asp Phe Arg Asp Ile Thr Gln Ser Gly Ser Phe Met Thr Ser 
            900                 905                 910         


Trp Cys His Gly Ala Pro Gly Ile Gly Ile Ala Arg Ala Cys Leu Trp 
        915                 920                 925             


Gln Thr Glu Leu Trp Asp Glu Gln Cys Arg Asp Glu Ile His Ala Ala 
    930                 935                 940                 


Ile Arg Thr Thr Ser Lys Ser Ile Gly Gln Leu Arg Ser Asp His Leu 
945                 950                 955                 960 


Cys Cys Gly Lys Ala Gly Leu Ala Ile Ile Leu Glu Met Leu Cys Asp 
                965                 970                 975     


Gly Pro Trp Gly Val Glu Ala His Val Ala Asp Leu Ala Arg Glu Arg 
            980                 985                 990         


Thr Ile Gln Ile His Thr Ser Leu  Met Asn Arg Thr Ser  Ser Lys Met 
        995                 1000                 1005             


Pro Asp  Leu Ile Cys Phe Ala  Ala Lys Glu Thr Ser  Leu Val Leu 
    1010                 1015                 1020             


Pro Gly  Phe Phe Thr Gly Leu  Ser Gly Ile Gly Met  Ala Leu Leu 
    1025                 1030                 1035             


Arg Asp  Asp Gln Ser Lys Gln  Thr Thr Arg Arg Leu  Leu Thr Ala 
    1040                 1045                 1050             


Gly Leu  Trp Thr Glu 
    1055             


<210>  4
<211>  297
<212>  PRT
<213>  Prochlorococcus marinus

<400>  4

Lys Pro Lys Asp Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala 
1               5                   10                  15      


Asp Leu Asn Thr His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile 
            20                  25                  30          


His Asn Gly Asn Gly Tyr Gly Tyr Met Glu His Val Val His His Leu 
        35                  40                  45              


Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg 
    50                  55                  60                  


Leu Thr Ala Leu Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu 
65                  70                  75                  80  


Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr 
                85                  90                  95      


Leu Leu Glu Ala Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr 
            100                 105                 110         


Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln Arg Ser 
        115                 120                 125             


Val Leu Arg Ser Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser 
    130                 135                 140                 


Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly Met Ser Pro Pro Asn Lys 
145                 150                 155                 160 


Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp Gly Met 
                165                 170                 175     


Met Pro Gly Arg Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro 
            180                 185                 190         


Val Gly Ile Gly Glu Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe 
        195                 200                 205             


Cys Asp Gly Phe Ser Met Gln Ser Glu Ala Leu Ile Lys Leu Arg Asn 
    210                 215                 220                 


Arg Trp Leu Asp Val Asn Gly Val Leu Ala His Phe Ala Gly Leu Pro 
225                 230                 235                 240 


Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile Gln Arg 
                245                 250                 255     


Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln Ala Leu 
            260                 265                 270         


Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro 
        275                 280                 285             


Leu His Trp Pro Ile Phe Ala Ala Glu 
    290                 295         


<210>  5
<211>  131
<212>  PRT
<213>  Prochlorococcus marinus

<400>  5

Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu Leu Gly 
1               5                   10                  15      


Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His Leu His 
            20                  25                  30          


Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala Ala Leu 
        35                  40                  45              


Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp Pro Asp 
    50                  55                  60                  


Tyr Arg Ser Ile Gly Arg Asp Ser Asp Ser Asp Glu Pro Ser Phe Met 
65                  70                  75                  80  


Ala Ser Trp Cys His Gly Ala Pro Gly Ile Ala Leu Gly Arg Ala Cys 
                85                  90                  95      


Leu Trp Gly Thr Ala Leu Trp Asp Glu Glu Cys Thr Lys Glu Ile Gly 
            100                 105                 110         


Ile Gly Leu Gln Thr Thr Ala Ala Val Ser Ser Val Ser Thr Asp His 
        115                 120                 125             


Leu Cys Cys 
    130     


<210>  6
<211>  285
<212>  PRT
<213>  Prochlorococcus marinus

<400>  6

Ala Thr Leu Ala Asp Leu Asn Ala His Ser Asp Leu Ser Pro Leu Arg 
1               5                   10                  15      


Thr Leu Ala Ile His Asn Gly Asp Gly Tyr Gly Tyr Met Glu His Val 
            20                  25                  30          


Val His His Phe Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe Tyr Phe 
        35                  40                  45              


Asn Ala Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys Thr Asp 
    50                  55                  60                  


Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu Leu Ile 
65                  70                  75                  80  


Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile Ser Asp 
                85                  90                  95      


Ala Ser Ser Thr Thr Ala Gln Pro Glu Pro Ser Thr Leu Gln Arg Gln 
            100                 105                 110         


Phe Gln Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp Met Phe 
        115                 120                 125             


Leu Gly Glu Ser Lys Gln Ala Ile Asp Ile Ser Ala Leu Gly Ile Ser 
    130                 135                 140                 


Pro Pro Asn Lys Pro Glu Arg Ile Ala Ala Gly Trp Leu Gly Phe Asn 
145                 150                 155                 160 


Ser Asp Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu Ile Pro 
                165                 170                 175     


Thr Ser Leu Pro Val Gly Ile Ala Asp Val Asn Pro Phe Asp Arg Phe 
            180                 185                 190         


Leu Glu Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Lys Ala Leu Ile 
        195                 200                 205             


Lys Leu Arg Asn Arg Trp Leu Asp Leu Asn Gly Ile Leu Ala His Phe 
    210                 215                 220                 


Ala Gly Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr Phe 
225                 230                 235                 240 


Asn Ile Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser Ser Leu 
                245                 250                 255     


Ala Gln Ala Leu Lys Leu Glu Gln Leu Ala Arg Ser Phe Leu Leu Ala 
            260                 265                 270         


Glu Ser Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu 
        275                 280                 285 


<210>  7
<211>  131
<212>  PRT
<213>  Prochlorococcus marinus

<400>  7

Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Ala Leu Leu Gly 
1               5                   10                  15      


Phe Ser His Gly Val Ala Gly Tyr Ala Ala Ala Leu Ala His Leu His 
            20                  25                  30          


Ala Phe Ser Gly Asp Glu Arg Tyr Arg Ile Ala Ala Ala Ala Ala Leu 
        35                  40                  45              


Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp Pro Asp 
    50                  55                  60                  


Tyr Arg Ser Ile Ser Arg Asp Ser Asp Ser Asp Glu Pro Ser Phe Met 
65                  70                  75                  80  


Ala Ser Trp Cys His Gly Ala Pro Gly Ile Ala Leu Gly Arg Ala Cys 
                85                  90                  95      


Leu Trp Gly Thr Ala Leu Trp Asp Glu Glu Cys Thr Lys Glu Ile Gly 
            100                 105                 110         


Ile Gly Leu Gln Thr Thr Ala Ala Val Ser Ala Val Ser Thr Asp His 
        115                 120                 125             


Leu Cys Cys 
    130     


<210>  8
<211>  295
<212>  PRT
<213>  Synechococcus sp.

<400>  8

Lys Pro Lys Asp Met Ala Val Asp Ala Ala Tyr Gln Asp Leu Leu Lys 
1               5                   10                  15      


Asp Ile Asn Arg Ser Ser Ser Asp Lys Pro Leu Lys Ile Leu Lys Ile 
            20                  25                  30          


His Asn Gly Glu Gly Tyr Gly Tyr Met Glu Tyr Val Ser His Lys Pro 
        35                  40                  45              


Ala Arg Asp Asp Lys Glu Leu Gly Phe Phe Tyr Lys Asn Ala Gly Arg 
    50                  55                  60                  


Leu Thr Ala Val Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu 
65                  70                  75                  80  


Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr 
                85                  90                  95      


Leu Leu Glu Ala Glu Leu Pro Asn His Ile Asn Asn Asp Thr Ser Glu 
            100                 105                 110         


Ala Pro Glu Leu Ser Ala Leu Gln Lys Arg Cys Gln Arg Ser Ile Leu 
        115                 120                 125             


Arg Ser Gly Leu Met Pro Gln Trp Met Phe Leu Gly Ser Glu Lys Ile 
    130                 135                 140                 


Ala Ile Asp Ile Ser Ala Leu Gly Ile Ser Pro Pro Lys Gln Glu Thr 
145                 150                 155                 160 


Gln Lys Thr Ser Gly Trp Leu Gly Leu Asn Ser Asp Gly Met Met Pro 
                165                 170                 175     


Gly Val Ile Glu Arg Asn Ala Asp Leu Pro Thr Ser Leu Pro Ile Gly 
            180                 185                 190         


Ile Gly Ser Pro Asn Pro Phe Ser Leu His Leu Asp Thr Phe Cys Glu 
        195                 200                 205             


Gly Phe Arg Glu Gln Asn Gln Thr Leu Ile Glu Gln Lys Asp Gln Trp 
    210                 215                 220                 


Leu Lys Glu Gly Thr Phe Leu Asn Arg Phe Lys Gly Leu Arg Arg Arg 
225                 230                 235                 240 


Ile Val Leu Arg Ala Thr Arg Val Tyr Phe Ala Ile Gln Arg Gln Gln 
                245                 250                 255     


Leu Glu Pro Ala Ala Leu Arg Ser Pro Leu Ile Gln Ala Ile Lys Leu 
            260                 265                 270         


Glu Gln Leu Ser Arg Ser Phe Leu Leu Ala Glu Gln Lys Pro Leu His 
        275                 280                 285             


Trp Pro Val Phe Ala Ala Glu 
    290                 295 


<210>  9
<211>  109
<212>  PRT
<213>  Synechococcus sp.

<400>  9

His Gly Thr Ala Gly His Ala Ala Ala Leu Ala Lys Leu His Gln Ala 
1               5                   10                  15      


Thr His Asp Asn Arg Phe Leu Glu Gly Ala Lys Ala Ala Leu His His 
            20                  25                  30          


Glu Arg Ala His Phe Asp Ser Lys Glu Glu Asn Trp Pro Asp Phe Arg 
        35                  40                  45              


Asp Ile Thr Gln Ser Gly Ser Phe Met Thr Ser Trp Cys His Gly Ala 
    50                  55                  60                  


Pro Gly Ile Gly Ile Ala Arg Ala Cys Leu Trp Gln Thr Glu Leu Trp 
65                  70                  75                  80  


Asp Glu Gln Cys Arg Asp Glu Ile His Ala Ala Ile Arg Thr Thr Ser 
                85                  90                  95      


Lys Ser Ile Gly Gln Leu Arg Ser Asp His Leu Cys Cys 
            100                 105                 


<210>  10
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  10

Met Lys Lys Arg Leu Asn Asn Gln Ser Met Ser Glu Glu Gln Leu Lys 
1               5                   10                  15      


Ala Phe Ile Ala Lys Val Gln Ala Asp Thr Ser Leu Gln Glu Gln Leu 
            20                  25                  30          


Lys Ala Glu Gly Ala Asp Val Val Ala Ile Ala Lys Ala Ala Gly Phe 
        35                  40                  45              


Ser Ile Thr Thr Glu Asp Leu Glu Lys Glu His Arg Gln Thr Leu Ser 
    50                  55                  60                  


Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
65                  70                  


<210>  11
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  11

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Glu Lys 
        35                  40                  45              


Glu His Arg Gln Thr Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly 
    50                  55                  60                  


Gly 
65  


<210>  12
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  12

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Pro Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ser 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Ile Thr Thr Lys Leu Asn Leu Ser Glu Glu Glu Leu Glu Gly Val 
    50                  55                  60                  


Ala Gly Ala 
65          


<210>  13
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  13

Met Ser Glu Glu Gln Leu Lys Gly Phe Leu Ser Lys Val Gln Ser Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Glu Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  14
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  14

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Thr Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  15
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  15

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Leu His Gly Ala 
    50                  55                  60                  


<210>  16
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  16

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Asp Asp Phe Glu Arg 
        35                  40                  45              


Asn Thr His Arg Gln Thr Leu Ser Asp Asp Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  17
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  17

Met Lys His Arg Gln Leu Asn Leu Met Ser Glu Glu Gln Leu Lys Ala 
1               5                   10                  15      


Phe Ile Ala Lys Val Gln Ala Asp Thr Ser Leu Gln Glu Gln Leu Lys 
            20                  25                  30          


Val Glu Gly Ala Asp Val Val Ala Ile Ala Lys Ala Ser Gly Phe Ala 
        35                  40                  45              


Ile Thr Thr Glu Asp Leu Lys Ala His Gln Ala Asn Ser Gln Lys Asn 
    50                  55                  60                  


Leu Ser Asp Ala Glu Leu Glu Gly Val Ala Gly Gly 
65                  70                  75      


<210>  18
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  18

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ser Gly Phe Ala Ile Thr Thr Glu Asp Leu Lys Ala 
        35                  40                  45              


His Gln Ala Asn Ser Gln Lys Asn Leu Ser Asp Ala Glu Leu Glu Gly 
    50                  55                  60                  


Val Ala Gly Gly 
65              


<210>  19
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  19

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Trp Asp Gln 
        35                  40                  45              


Arg Pro Val Arg Thr Leu Ser Asp Glu Glu Leu Glu Gly Ala Ala Gly 
    50                  55                  60                  


Gly 
65  


<210>  20
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  20

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Pro Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Thr Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Asp Glu Leu Glu Ser Val Ala Gly Gly 
    50                  55                  60                  


<210>  21
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  21

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Lys Glu Lys Leu Lys Ala Ala Lys Ser Pro Glu Asp Val 
            20                  25                  30          


Val Gly Ile Ala Lys Glu His Gly His Glu Phe Thr Ala Asp Lys Ile 
        35                  40                  45              


Ser Gln Leu Ser Glu Glu Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60          


<210>  22
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  22

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Ile Glu Met Thr Asp Asp Glu Leu Glu Gly Val Ala Gly 
    50                  55                  60                  


Gly 
65  


<210>  23
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  23

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Glu Ala Glu Val Lys Ala 
        35                  40                  45              


Tyr Gln Thr Arg Asn Leu Ser Asp Glu Glu Leu Asp Glu Val Ala Gly 
    50                  55                  60                  


Gly 
65  


<210>  24
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  24

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Ser Thr Glu Asp Leu Asn Asn 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  25
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  25

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Ala Thr Glu Asp Leu Lys Thr 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  26
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  26

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Thr Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ile Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  27
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  27

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Pro Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Lys Thr 
        35                  40                  45              


Ala Arg Gln Thr Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  28
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  28

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ser 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Glu Glu Leu Glu Gly Ala Ala Gly Gly 
    50                  55                  60                  


<210>  29
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  29

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Lys Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Thr Leu Ser Glu Asp Glu Leu Glu Ser Val Ala Gly Gly 
    50                  55                  60                  


<210>  30
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  30

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Arg Thr Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  31
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  31

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Gly Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Lys Gln Gln Asp Leu Asn Ala 
        35                  40                  45              


Ala Ala Ser Glu Leu Ser Asp Glu Glu Leu Glu Ala Ala Ser Gly Gly 
    50                  55                  60                  


<210>  32
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  32

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Arg Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  33
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  33

Met Leu Leu Ala Glu Glu Thr Ile Glu Leu Ser Ile Pro Phe Phe Gln 
1               5                   10                  15      


Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
            20                  25                  30          


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
        35                  40                  45              


Leu Val Ile Ala Lys Asp Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
    50                  55                  60                  


Lys Asn Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Gly 
        


<210>  34
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  34

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Val Ile Ala Lys Asp Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  35
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  35

Met Ser Glu Glu Gln Leu Lys Ala Leu Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Thr Leu Ser Val Gly Arg Gln Thr Leu Ser Glu Ser Glu 
    50                  55                  60                  


Leu Glu Gly Leu Ala Gly Gly 
65                  70      


<210>  36
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  36

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Ala Leu Ser Asp Asp Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  37
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  37

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  38
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  38

Met His Ser Ser Ala Leu Gly Trp Ala Lys Ile Arg Lys Ser Asp Ala 
1               5                   10                  15      


Thr Lys Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys 
            20                  25                  30          


Gly Asp Thr Ser Leu Gln Glu Lys Leu Gln Ala Ala Ala Asp Ser Asp 
        35                  40                  45              


Ala Val Leu Ala Ile Ala Lys Glu Ala Gly Phe Met Ile Ser Ala Asp 
    50                  55                  60                  


Glu Leu Lys Lys Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser 
65                  70                  75                  80  


Ala Ala Gly Gly 
                


<210>  39
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  39

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Gln Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Glu Ala Gly Phe Met Ile Ser Ala Asp Glu Leu 
        35                  40                  45              


Lys Lys Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Ala Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  40
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  40

Met Leu Leu Ala Glu Glu Thr Ile Glu Leu Ser Ile Pro Phe Phe Gln 
1               5                   10                  15      


Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
            20                  25                  30          


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
        35                  40                  45              


Leu Val Ile Ala Lys Asp Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
    50                  55                  60                  


Lys Asn Ala Gln Ser Glu Ile Ser Glu Glu Glu Leu Glu Ser Val Ala 
65                  70                  75                  80  


Gly Gly 
        


<210>  41
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  41

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Gly Ser Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Ala Ala Gly Leu Met Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Thr Lys Ala Gln Ser Glu Ile Ser Asp Ala Glu Leu Glu Asp Ala Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  42
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  42

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Thr Asn Ala Val 
            20                  25                  30          


Ser Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Thr Lys Ala Gln Ser Glu Ile Ser Asp Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  43
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  43

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Lys Asp 
1               5                   10                  15      


Thr Asn Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Tyr Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Glu Ala Gly Phe Met Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Leu Ser Asp Gln Glu Leu Glu Gly Ala Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  44
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  44

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ala Asn Ala Val 
            20                  25                  30          


Ala Ala Ile Ala Lys Glu Ser Gly Phe Ser Ile Ser Val Glu Asp Ile 
        35                  40                  45              


Asn Lys Ala Gln Ser Glu Leu Ser Asp Lys Glu Leu Glu Gly Val Ser 
    50                  55                  60                  


Gly Gly 
65      


<210>  45
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  45

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ser Asp Val Ile Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Val Ile Thr Lys Glu Asp Leu Lys Ala 
        35                  40                  45              


His Arg Gln Asn Leu Ser Glu Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  46
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  46

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Glu Lys Val Gln Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Val Ala Asp Ala Asp Ala Val 
            20                  25                  30          


Ala Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Thr Lys Asp Gln Ser Glu Leu Ser Asp Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  47
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  47

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Asp Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Lys Glu 
        35                  40                  45              


His Arg Gln Asn Leu Ser Glu Lys Asp Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  48
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  48

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Asp Val Ala Gly Gly 
    50                  55                  60                  


<210>  49
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  49

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Thr Glu Asp Leu Gln Ala 
        35                  40                  45              


Asn Gln Gln Asn Leu Ser Asp Gln Glu Leu Glu Gly Ala Ala Gly Gly 
    50                  55                  60                  


<210>  50
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  50

Met Lys His Arg Gln Leu Asn Leu Met Ser Glu Glu Gln Leu Lys Ala 
1               5                   10                  15      


Phe Ile Ala Lys Val Gln Ala Asp Ala Ser Leu Gln Glu Gln Leu Lys 
            20                  25                  30          


Ala Glu Gly Ala Asp Val Val Val Ile Ala Lys Ala Ala Gly Phe Ala 
        35                  40                  45              


Ile Thr Lys Glu Asp Leu Asn Thr His Arg Gln Thr Leu Ser Asp Asn 
    50                  55                  60                  


Glu Leu Glu Gly Val Ala Gly Gly 
65                  70          


<210>  51
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  51

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Val 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ala Ile Thr Lys Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Thr Leu Ser Asp Asn Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  52
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  52

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Gln Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Ala Ala Asp Thr Asp Ala Val 
            20                  25                  30          


Ala Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Glu Asp Leu 
        35                  40                  45              


Thr Gln Ala Gln Leu Glu Leu Ser Glu Glu Glu Leu Glu Ser Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  53
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  53

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Phe Thr Thr Glu Asp Leu Thr Leu 
        35                  40                  45              


Tyr Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  54
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  54

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ala Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Pro Ile Ala 
            20                  25                  30          


Ile Ala Lys Val Ala Gly Phe Ser Ile Thr Gln Ala Asp Leu Glu Ala 
        35                  40                  45              


Asn Trp Lys Glu Ser Ser Arg Glu Leu Ser Asp Ala Asp Leu Glu Asn 
    50                  55                  60                  


Val Ser Gly Gly 
65              


<210>  55
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  55

Met Lys Ile Thr Asp Ala Asp Ser Ile Ala Ser Ile Ala Lys Glu Ala 
1               5                   10                  15      


Gly Phe Glu Ile Thr Ala Asp Glu Val Lys Lys Ala Gln Ser Thr Leu 
            20                  25                  30          


Pro Asp Glu Pro Leu Asp Leu Asp Ala Gly Gly 
        35                  40              


<210>  56
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  56

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ser Asp Ala Asp Ala Val 
            20                  25                  30          


Val Ala Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu 
        35                  40                  45              


Asn Ser His Arg Gln Asn Leu Thr Glu Asp Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  57
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  57

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Val Gln Glu Lys Leu Lys Ala Ala Ser Asp Ala Asp Ala Val 
            20                  25                  30          


Val Ala Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu 
        35                  40                  45              


Asn Ser His Arg Gln Asn Leu Thr Glu Asp Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  58
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  58

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu 
        35                  40                  45              


Asn Ser His Arg Gln Asn Leu Thr Glu Asp Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  59
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  59

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Asn Asp Ala Val 
            20                  25                  30          


Thr Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Leu Ser Asp Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  60
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader - Ident SEQ ID 59

<400>  60

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Asn Asp Ala Val 
            20                  25                  30          


Thr Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Leu Ser Asp Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  61
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  61

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Thr Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ser Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Val Ser Glu Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  62
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  62

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ala Asp Ala Val 
            20                  25                  30          


Thr Ala Ile Ala Asn Glu Ala Gly Phe Ser Ile Ser Ala Asn Asp Leu 
        35                  40                  45              


Thr Lys Leu Gln Ser Glu Leu Ser Asp Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  63
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  63

Met Gln Lys Arg Leu Glu Ala Phe Leu Glu Lys Val Lys Ala Asp Thr 
1               5                   10                  15      


Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Thr Asn Ala Val Val 
            20                  25                  30          


Ala Ile Ala Lys Asp Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu Thr 
        35                  40                  45              


Lys Ala Gln Pro Thr Leu Ser Glu Glu Glu Leu Glu Gly Val Ala Gly 
    50                  55                  60                  


Gly 
65  


<210>  64
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  64

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Gly Leu Gln Glu Lys Leu Lys Ala Ala Ser Asp Ala Asn Ala Val 
            20                  25                  30          


Ala Ala Ile Ala Gln Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Lys Ala Glu Ser Glu Ile Val Glu Glu Val Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  65
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  65

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ser Asp Ala Asn Ala Ala 
            20                  25                  30          


Ser Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Glu Phe 
        35                  40                  45              


Thr Lys Ala Pro Ser Thr Glu Leu Ser Ala Glu Glu Leu Glu Gly Val 
    50                  55                  60                  


Ala Gly Gly 
65          


<210>  66
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  66

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Ile Leu Lys Asn Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Ala Asp Ala Val 
            20                  25                  30          


Leu Ala Ile Ala Lys Glu Ala Gly Phe Ile Val Ser Pro Asp Asp Leu 
        35                  40                  45              


Phe Lys Ala Gln Ser Glu Leu Ser Asp Gln Asp Met Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly 
65      


<210>  67
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  67

Gly Ser 
1       


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  69

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  70
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30  


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Gly Gly Gly Gly Ser 
1               5   


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
1               5                   10  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  73

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  74
<211>  324
<212>  PRT
<213>  Planktothrix agardhii

<400>  74

Met Ser Leu Ser Arg Asp Val Val Leu Leu Ile Thr His Ser Gly Asp 
1               5                   10                  15      


Phe Phe Thr Ile Asp Arg Val Ile Glu Ala Leu Leu Lys Lys Gly Val 
            20                  25                  30          


Gln Pro Phe Arg Phe Asp Thr Asp Gln Phe Pro Leu Asn Val Gln Leu 
        35                  40                  45              


Thr Ala Asn Phe Gly Lys Ser Asn Ser Asp His Gln Leu Glu Tyr Asn 
    50                  55                  60                  


Gly Asn Ser Ile Ser Thr Lys Gln Val Gln Ala Val Trp Leu Arg Arg 
65                  70                  75                  80  


Ile Trp Glu Pro Asp Phe Gln Glu Leu Asp Pro Gln Tyr Gln Gln Ala 
                85                  90                  95      


Cys Ala Lys Glu Ser Lys Ala Thr Leu Asn Gly Phe Trp Asp Ser Leu 
            100                 105                 110         


Arg Asp Ala Asn Trp Val Asp His Leu Ala Gln Ile Glu Ala Ala Ser 
        115                 120                 125             


Asn Lys Leu Leu Gln Leu Arg Leu Ala Ser Glu Val Gly Phe Thr Ile 
    130                 135                 140                 


Pro Gln Thr Leu Ile Thr Asn Lys Ala Glu Ala Ala Arg Glu Phe Phe 
145                 150                 155                 160 


Gln Gln Val Asn Gly Lys Met Val Ser Lys Leu Leu Thr Ala Leu Ser 
                165                 170                 175     


Arg Ser Met Glu Ser Thr Ser Phe Phe Leu Tyr Thr Ser Leu Val Lys 
            180                 185                 190         


Glu Glu Tyr Leu Gln Asp Ala Glu Ser Leu Arg Tyr Cys Pro Met Val 
        195                 200                 205             


Phe Gln Glu Gln Ile Phe Lys Gln Gln Glu Leu Arg Val Ile Tyr Val 
    210                 215                 220                 


Asn Gly Lys Val Phe Val Gly Ala Leu Asn Ala Ser Val Tyr Glu Asp 
225                 230                 235                 240 


Ser Thr Val Asp Trp Arg Ala Pro Gly Ile Glu Val Gly Ala Trp Gln 
                245                 250                 255     


Asn His Gln Leu Pro Glu Glu Leu Ile Arg Arg Leu Gln Thr Phe Met 
            260                 265                 270         


Gly Glu Leu Gly Leu Leu Phe Gly Ala Phe Asp Phe Ile Leu Thr Pro 
        275                 280                 285             


Ser Gly Asp Tyr Val Phe Leu Glu Val Asn Pro Gly Gly Glu Trp Gly 
    290                 295                 300                 


Met Leu Glu Arg Asp Leu Asp Leu Pro Ile Ser Gln Ala Ile Ala Asp 
305                 310                 315                 320 


Thr Leu Ile Pro 
                


<210>  75
<211>  330
<212>  PRT
<213>  Planktothrix agardhii

<400>  75

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
145                 150                 155                 160 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
                165                 170                 175     


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
    210                 215                 220                 


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
                245                 250                 255     


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
        275                 280                 285             


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
305                 310                 315                 320 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe 
                325                 330 


<210>  76
<211>  34
<212>  PRT
<213>  Planktothrix agardhii

<400>  76

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro 
        


<210>  77
<211>  324
<212>  PRT
<213>  Planktothrix prolifica

<400>  77

Met Ser Leu Ser Arg Asp Val Val Leu Leu Ile Thr His Ser Gly Asp 
1               5                   10                  15      


Phe Phe Thr Ile Asp Arg Val Ile Glu Ala Leu Leu Lys Lys Gly Val 
            20                  25                  30          


Gln Pro Phe Arg Phe Asp Thr Asp Gln Phe Pro Leu Asn Val Gln Leu 
        35                  40                  45              


Thr Ala Asn Phe Gly Lys Leu Lys Ser Asp His Gln Leu Glu Tyr Asn 
    50                  55                  60                  


Gly His Ser Ile Ser Thr Lys Gln Val Gln Ala Val Trp Leu Arg Arg 
65                  70                  75                  80  


Ile Trp Glu Pro Asp Phe Gln Glu Leu Asp Pro Gln Tyr Gln Gln Ala 
                85                  90                  95      


Cys Ala Lys Glu Ser Lys Ala Thr Leu Asn Gly Phe Trp Asp Ser Leu 
            100                 105                 110         


Arg Glu Ala Asn Trp Val Asp His Leu Ala Lys Ile Glu Ala Ala Ser 
        115                 120                 125             


Asn Lys Leu Leu Gln Leu Arg Leu Ala Ser Glu Leu Gly Phe Thr Ile 
    130                 135                 140                 


Pro Gln Thr Leu Ile Thr Asn Lys Ala Glu Ala Ala Arg Glu Phe Phe 
145                 150                 155                 160 


Gln Gln Val Asn Gly Lys Met Val Ser Lys Leu Leu Thr Ala Leu Ser 
                165                 170                 175     


Arg Ser Met Glu Ser Thr Ser Phe Phe Leu Tyr Thr Ser Leu Val Lys 
            180                 185                 190         


Glu Glu Asp Leu Gln Asp Ala Glu Ser Leu Arg Tyr Cys Pro Met Val 
        195                 200                 205             


Phe Gln Glu Gln Ile Ser Lys Gln Gln Glu Leu Arg Val Ile Tyr Val 
    210                 215                 220                 


Asn Gly Lys Val Phe Val Gly Ala Leu Asn Ala Ser Val Tyr Glu Asp 
225                 230                 235                 240 


Ser Thr Val Asp Trp Arg Ser Pro Gly Ile Glu Val Gly Ala Trp Gln 
                245                 250                 255     


Asn His Gln Leu Pro Glu Glu Leu Ile Arg Arg Leu Gln Thr Phe Met 
            260                 265                 270         


Gly Glu Leu Gly Leu Leu Phe Gly Ala Phe Asp Phe Ile Leu Thr Pro 
        275                 280                 285             


Ser Gly Asp Tyr Val Phe Leu Glu Val Asn Pro Gly Gly Glu Trp Gly 
    290                 295                 300                 


Met Leu Glu Arg Asp Leu Asn Leu Pro Ile Ser Gln Ala Ile Ala Asp 
305                 310                 315                 320 


Thr Leu Ile Pro 
                


<210>  78
<211>  330
<212>  PRT
<213>  Planktothrix prolifica

<400>  78

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu Gln Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Glu Cys Lys Glu 
145                 150                 155                 160 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
                165                 170                 175     


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
    210                 215                 220                 


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu Thr Glu Lys Trp Gln Thr Tyr 
                245                 250                 255     


Asn Leu Pro Glu Asp Ile Gln Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
        275                 280                 285             


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Phe Ser Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
305                 310                 315                 320 


Leu Leu Thr Pro Thr Asn His Leu Ser Asp 
                325                 330 


<210>  79
<211>  36
<212>  PRT
<213>  Planktothrix prolifica

<400>  79

Met Ser Lys Asn Ile Lys Val Ser Thr Gly Ser Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ser Glu Gln Asp Thr Glu Thr Gly Asp Ser Thr Ser 
            20                  25                  30          


Thr Asp Ile Pro 
        35      


<210>  80
<211>  325
<212>  PRT
<213>  Microcystis aeruginosa


<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  Xaa can be any naturally occurring amino acid

<400>  80

Met Lys Glu Ser Pro Lys Val Val Leu Leu Leu Thr His Ser Gly Asp 
1               5                   10                  15      


Phe Phe Thr Ile Asp Arg Val Ala Glu Ala Ile Glu Lys Lys Gly Ala 
            20                  25                  30          


Thr Pro Phe Arg Leu Asp Thr Asp Lys Phe Pro Leu Glu Val Gln Leu 
        35                  40                  45              


Ala Ala Gln Phe Asn Gly Lys Lys Ser Phe Tyr Gln Leu Thr Tyr Asn 
    50                  55                  60                  


His Gln Ser Ile Asp Ser Glu Gln Val Gln Ser Val Trp Thr Arg Arg 
65                  70                  75                  80  


Ile Trp Gln Pro Glu Ile Thr Gly Asp Leu Asp Pro Gln Phe Arg Glu 
                85                  90                  95      


Ala Cys Val Arg Glu Ser Gln Thr Thr Leu Ala Gly Phe Trp Asp Ser 
            100                 105                 110         


Leu Arg Ser Ala Arg Trp Leu Asp Asn Leu Ala Gln Ile Glu Arg Ala 
        115                 120                 125             


Lys Asn Lys Leu Leu Gln Leu Arg Leu Ala Ser Glu Val Gly Leu Ile 
    130                 135                 140                 


Ile Pro Pro Thr Leu Val Thr Asn Asn Pro Asp Ala Ala Arg Glu Phe 
145                 150                 155                 160 


Phe Ser Gln Val Gln Gly Arg Met Val Ser Lys Leu Leu Thr Ala Ile 
                165                 170                 175     


Ala Arg Ser Met Glu Ser Pro Glu Phe Phe Leu Tyr Thr Ser Arg Val 
            180                 185                 190         


Lys Ala Glu Asp Leu Glu Glu Ala Glu Ser Leu Arg Tyr Cys Pro Met 
        195                 200                 205             


Val Phe Gln Ala Glu Ile Pro Lys Gln Leu Glu Leu Arg Val Val Val 
    210                 215                 220                 


Val Asn Gly Gln Thr Phe Val Gly Ala Leu Glu Ser Ser Gln Tyr Asn 
225                 230                 235                 240 


Asn Ser Ala Val Asp Trp Arg Arg Pro Xaa Ile Asp Pro Gly Ala Trp 
                245                 250                 255     


Gln His His Thr Leu Pro Asp Ser Leu Leu Gln Gln Leu Gln Ile Phe 
            260                 265                 270         


Met Ala Asn Leu Gly Leu Asn Phe Gly Ala Phe Asp Phe Ile Leu Thr 
        275                 280                 285             


Pro Gly Gly Glu Tyr Val Phe Leu Glu Val Asn Pro Gly Gly Glu Trp 
    290                 295                 300                 


Gly Met Leu Glu Arg Asp Leu Asp Leu Pro Ile Ser Asn Ala Ile Ala 
305                 310                 315                 320 


Asp Phe Leu Val Cys 
                325 


<210>  81
<211>  324
<212>  PRT
<213>  Microcystis aeruginosa

<400>  81

Met Thr Val Leu Ile Val Thr Phe Ser His Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Ile Lys Ala Ile Glu Thr Met Gly Lys Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Val Asp Leu Tyr Ser Gly 
        35                  40                  45              


Gly Gln Lys Gly Gly Ile Ile Thr Asp Gly Asp Gln Lys Leu Glu Leu 
    50                  55                  60                  


Lys Glu Val Ser Ala Val Trp Tyr Arg Arg Met Arg Tyr Gly Leu Lys 
65                  70                  75                  80  


Leu Pro Asp Gly Met Asp Ser Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Ser Ile Arg Gly Met Ile Ala Ser Leu Ser Gly Phe His 
            100                 105                 110         


Leu Asp Pro Ile Ala Lys Val Asp His Ala Asn His Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Val Ala Gln Gln Leu Gly Leu Leu Ile Pro Gly Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Glu Phe Glu Ala 
145                 150                 155                 160 


Thr Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Asp 
                165                 170                 175     


Lys Gln Glu Glu Met Val Val Phe Thr Ser Pro Val Thr Lys Glu Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Gln Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Ile Pro Lys Ala Leu Glu Leu Arg Ile Thr Ile Val Gly Glu Gln 
    210                 215                 220                 


Ile Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Ile Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Gln Gln Trp Gln Pro Tyr 
                245                 250                 255     


Asp Leu Pro Lys Thr Ile Glu Lys Gln Leu Leu Glu Leu Val Lys Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Met Ile Val Thr Pro Asp Glu 
        275                 280                 285             


Arg Tyr Ile Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Tyr Pro Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Val 
305                 310                 315                 320 


Leu Val Asn Ser 
                


<210>  82
<211>  35
<212>  PRT
<213>  Microcystis aeruginosa

<400>  82

Ala Tyr Pro Asn Asp Gln Gln Gly Lys Ala Leu Pro Phe Phe Ala Arg 
1               5                   10                  15      


Phe Leu Ser Val Ser Lys Glu Glu Ser Ser Ile Lys Ser Pro Ser Pro 
            20                  25                  30          


Glu Pro Thr 
        35  


<210>  83
<211>  1174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  83

Met Lys His Arg Gln Leu Asn Leu Met Ser Glu Glu Gln Leu Lys Ala 
1               5                   10                  15      


Phe Ile Ala Lys Val Gln Ala Asp Thr Ser Leu Gln Glu Gln Leu Lys 
            20                  25                  30          


Val Glu Gly Ala Asp Val Val Ala Ile Ala Lys Ala Ser Gly Phe Ala 
        35                  40                  45              


Ile Thr Thr Glu Asp Leu Lys Ala His Gln Ala Asn Ser Gln Lys Asn 
    50                  55                  60                  


Leu Ser Asp Ala Glu Leu Glu Gly Val Ala Gly Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Glu Ser Pro Ser Ser 
            100                 105                 110         


Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala Pro Asp Glu Pro His Lys 
        115                 120                 125             


Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu Ser Glu Glu Asn Phe Phe 
    130                 135                 140                 


Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu Glu Glu Asp Asp Pro Cys 
145                 150                 155                 160 


Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu Ala Leu Lys Ala Ala Trp 
                165                 170                 175     


Asp Leu Pro Leu Leu Pro Val Asp Asn Asn Leu Asn Arg Pro Phe Val 
            180                 185                 190         


Asp Val Trp Trp Pro Ile Arg Cys His Ser Ala Glu Ser Leu Arg Gln 
        195                 200                 205             


Ser Phe Val Ser Asp Ser Ala Gly Leu Ala Asp Glu Ile Phe Asp Gln 
    210                 215                 220                 


Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys Ala Leu Gly Asp Gln Val 
225                 230                 235                 240 


Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr Pro Gly Thr Met Leu Leu 
                245                 250                 255     


Ala His Leu Gly Ala Ala Gly Asp Gly Ser Gly Pro Pro Val Arg Glu 
            260                 265                 270         


His Tyr Glu Arg Phe Ile Gln Ser His Arg Arg Asn Gly Leu Ala Pro 
        275                 280                 285             


Leu Leu Lys Glu Phe Pro Val Leu Gly Arg Leu Ile Gly Thr Val Leu 
    290                 295                 300                 


Ser Leu Trp Phe Gln Gly Ser Val Glu Met Leu Gln Arg Ile Cys Ala 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gln Gln Cys Phe Ala Ile Pro Cys Gly His His 
                325                 330                 335     


Leu Lys Thr Val Lys Gln Gly Leu Ser Asp Pro His Arg Gly Gly Arg 
            340                 345                 350         


Ala Val Ala Val Leu Glu Phe Ala Asp Pro Asn Ser Thr Ala Asn Ser 
        355                 360                 365             


Ser Met His Val Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala Ala 
    370                 375                 380                 


Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr His Ser Asp Leu Ser Pro 
385                 390                 395                 400 


Leu Arg Thr Leu Ala Ile His Asn Gly Asn Gly Tyr Gly Tyr Met Glu 
                405                 410                 415     


His Val Val His His Leu Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe 
            420                 425                 430         


Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys 
        435                 440                 445             


Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu 
    450                 455                 460                 


Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile 
465                 470                 475                 480 


Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln 
                485                 490                 495     


Lys Gln Phe Gln Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp 
            500                 505                 510         


Met Phe Leu Gly Glu Ser Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly 
        515                 520                 525             


Met Ser Pro Pro Asn Lys Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly 
    530                 535                 540                 


Phe Asn Ser Asp Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu 
545                 550                 555                 560 


Ile Pro Thr Ser Leu Pro Val Gly Ile Gly Glu Val Asn Pro Phe Asp 
                565                 570                 575     


Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Glu Ala 
            580                 585                 590         


Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp Val Asn Gly Val Leu Ala 
        595                 600                 605             


His Phe Ala Gly Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val 
    610                 615                 620                 


Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu 
                645                 650                 655     


Leu Ala Glu Ser Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu Val 
            660                 665                 670         


Lys Gln Met Gln His Leu Asp Ile Pro Phe Phe Thr His Leu Ile Asp 
        675                 680                 685             


Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu Gln Glu Leu Pro Gly Phe 
    690                 695                 700                 


Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr Glu Arg Leu Arg Asn Leu 
705                 710                 715                 720 


Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg Leu Ile Arg Gly Ala Val 
                725                 730                 735     


Glu Ala Arg Glu Leu His Thr Thr Pro Glu Ser Ser Pro Thr Leu Pro 
            740                 745                 750         


Pro Pro Ala Thr Pro Glu Ala Leu Met Ser Ser Ser Ala Glu Thr Ser 
        755                 760                 765             


Leu Glu Ala Ala Lys Arg Ile Ala His Arg Leu Leu Glu Leu Ala Ile 
    770                 775                 780                 


Arg Asp Ser Gln Gly Gln Val Glu Trp Leu Gly Met Asp Leu Gly Ala 
785                 790                 795                 800 


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Leu Ser Leu Tyr Gly 
                805                 810                 815     


Gly Ser Ile Gly Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln 
            820                 825                 830         


Val Ser Leu Met Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro 
        835                 840                 845             


Leu Val Gly Leu Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp 
    850                 855                 860                 


Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu 
865                 870                 875                 880 


Ala Leu Thr Leu Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala 
                885                 890                 895     


Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile 
            900                 905                 910         


Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu 
        915                 920                 925             


Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln 
    930                 935                 940                 


Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu 
945                 950                 955                 960 


Leu Gly Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His 
                965                 970                 975     


Leu His Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala 
            980                 985                 990         


Ala Leu Ala Tyr Glu Arg Ala Arg  Phe Asn Lys Asp Ala  Gly Asn Trp 
        995                 1000                 1005             


Pro Asp  Tyr Arg Ser Ile Gly  Arg Asp Ser Asp Ser  Asp Glu Pro 
    1010                 1015                 1020             


Ser Phe  Met Ala Ser Trp Cys  His Gly Ala Pro Gly  Ile Ala Leu 
    1025                 1030                 1035             


Gly Arg  Ala Cys Leu Trp Gly  Thr Ala Leu Trp Asp  Glu Glu Cys 
    1040                 1045                 1050             


Thr Lys  Glu Ile Gly Ile Gly  Leu Gln Thr Thr Ala  Ala Val Ser 
    1055                 1060                 1065             


Ser Val  Ser Thr Asp His Leu  Cys Cys Gly Ser Leu  Gly Leu Met 
    1070                 1075                 1080             


Val Leu  Leu Glu Met Leu Ser  Ala Gly Pro Trp Pro  Ile Asp Asn 
    1085                 1090                 1095             


Gln Leu  Arg Ser His Cys Gln  Asp Val Ala Phe Gln  Tyr Arg Leu 
    1100                 1105                 1110             


Gln Ala  Leu Gln Arg Cys Ser  Ala Glu Pro Ile Lys  Leu Arg Cys 
    1115                 1120                 1125             


Phe Gly  Thr Lys Glu Gly Leu  Leu Val Leu Pro Gly  Phe Phe Thr 
    1130                 1135                 1140             


Gly Leu  Ser Gly Met Gly Leu  Ala Leu Leu Glu Asp  Asp Pro Ser 
    1145                 1150                 1155             


Arg Ala  Val Val Ser Gln Leu  Ile Ser Ala Gly Leu  Trp Pro Thr 
    1160                 1165                 1170             


Glu 
    


<210>  84
<211>  1174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  84

Met Glu Ser Pro Ser Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Asn 
65                  70                  75                  80  


Leu Asn Arg Pro Phe Val Asp Val Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ser Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Gly Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Cys Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asn 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Leu Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Leu Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Met Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Gly 
    450                 455                 460                 


Glu Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Glu Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Val Asn Gly Val Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln His Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile Arg Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu Pro Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ser Ser Ala Glu Thr Ser Leu Glu Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ser Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ala His Leu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Gln Gln Val Ser Leu Met Asp Ala Asp Ala Ile Gln 
                725                 730                 735     


Thr Ala Ile Leu Gln Pro Leu Val Gly Leu Val Asp Gln Pro Ser Asp 
            740                 745                 750         


Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly 
        755                 760                 765             


Cys Gly Gly Thr Leu Leu Ala Leu Thr Leu Gln Gly Glu Gln Ala Met 
    770                 775                 780                 


Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp 
785                 790                 795                 800 


Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu 
                805                 810                 815     


Val Gln Leu Gly Thr Glu Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly 
            820                 825                 830         


Asp His Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser 
        835                 840                 845             


Ser Ser Gln Pro Gly Leu Leu Gly Phe Ser His Gly Thr Ala Gly Tyr 
    850                 855                 860                 


Ala Ala Ala Leu Ala His Leu His Ala Phe Ser Ala Asp Glu Arg Tyr 
865                 870                 875                 880 


Arg Thr Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn 
                885                 890                 895     


Lys Asp Ala Gly Asn Trp Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser 
            900                 905                 910         


Asp Ser Asp Glu Pro Ser Phe Met Ala Ser Trp Cys His Gly Ala Pro 
        915                 920                 925             


Gly Ile Ala Leu Gly Arg Ala Cys Leu Trp Gly Thr Ala Leu Trp Asp 
    930                 935                 940                 


Glu Glu Cys Thr Lys Glu Ile Gly Ile Gly Leu Gln Thr Thr Ala Ala 
945                 950                 955                 960 


Val Ser Ser Val Ser Thr Asp His Leu Cys Cys Gly Ser Leu Gly Leu 
                965                 970                 975     


Met Val Leu Leu Glu Met Leu Ser Ala Gly Pro Trp Pro Ile Asp Asn 
            980                 985                 990         


Gln Leu Arg Ser His Cys Gln Asp  Val Ala Phe Gln Tyr  Arg Leu Gln 
        995                 1000                 1005             


Ala Leu  Gln Arg Cys Ser Ala  Glu Pro Ile Lys Leu  Arg Cys Phe 
    1010                 1015                 1020             


Gly Thr  Lys Glu Gly Leu Leu  Val Leu Pro Gly Phe  Phe Thr Gly 
    1025                 1030                 1035             


Leu Ser  Gly Met Gly Leu Ala  Leu Leu Glu Asp Asp  Pro Ser Arg 
    1040                 1045                 1050             


Ala Val  Val Ser Gln Leu Ile  Ser Ala Gly Leu Trp  Pro Thr Glu 
    1055                 1060                 1065             


Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Gly 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser 
    1085                 1090                 1095             


Met Lys  His Arg Gln Leu Asn  Leu Met Ser Glu Glu  Gln Leu Lys 
    1100                 1105                 1110             


Ala Phe  Ile Ala Lys Val Gln  Ala Asp Thr Ser Leu  Gln Glu Gln 
    1115                 1120                 1125             


Leu Lys  Val Glu Gly Ala Asp  Val Val Ala Ile Ala  Lys Ala Ser 
    1130                 1135                 1140             


Gly Phe  Ala Ile Thr Thr Glu  Asp Leu Lys Ala His  Gln Ala Asn 
    1145                 1150                 1155             


Ser Gln  Lys Asn Leu Ser Asp  Ala Glu Leu Glu Gly  Val Ala Gly 
    1160                 1165                 1170             


Gly 
    


<210>  85
<211>  1174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  85

Met Glu Ser Pro Ser Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Asn 
65                  70                  75                  80  


Leu Asn Arg Pro Phe Val Asp Val Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ser Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Gly Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Cys Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asn 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Leu Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Leu Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Met Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Gly 
    450                 455                 460                 


Glu Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Glu Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Val Asn Gly Val Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln His Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile Arg Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu Pro Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ser Ser Ala Glu Thr Ser Leu Glu Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ser Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                725                 730                 735     


Gly Ser Gly Ser Met Lys His Arg Gln Leu Asn Leu Met Ser Glu Glu 
            740                 745                 750         


Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp Thr Ser Leu Gln 
        755                 760                 765             


Glu Gln Leu Lys Val Glu Gly Ala Asp Val Val Ala Ile Ala Lys Ala 
    770                 775                 780                 


Ser Gly Phe Ala Ile Thr Thr Glu Asp Leu Lys Ala His Gln Ala Asn 
785                 790                 795                 800 


Ser Gln Lys Asn Leu Ser Asp Ala Glu Leu Glu Gly Val Ala Gly Gly 
                805                 810                 815     


Gly Ser Ile Gly Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln 
            820                 825                 830         


Val Ser Leu Met Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro 
        835                 840                 845             


Leu Val Gly Leu Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp 
    850                 855                 860                 


Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu 
865                 870                 875                 880 


Ala Leu Thr Leu Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala 
                885                 890                 895     


Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile 
            900                 905                 910         


Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu 
        915                 920                 925             


Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln 
    930                 935                 940                 


Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu 
945                 950                 955                 960 


Leu Gly Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His 
                965                 970                 975     


Leu His Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala 
            980                 985                 990         


Ala Leu Ala Tyr Glu Arg Ala Arg  Phe Asn Lys Asp Ala  Gly Asn Trp 
        995                 1000                 1005             


Pro Asp  Tyr Arg Ser Ile Gly  Arg Asp Ser Asp Ser  Asp Glu Pro 
    1010                 1015                 1020             


Ser Phe  Met Ala Ser Trp Cys  His Gly Ala Pro Gly  Ile Ala Leu 
    1025                 1030                 1035             


Gly Arg  Ala Cys Leu Trp Gly  Thr Ala Leu Trp Asp  Glu Glu Cys 
    1040                 1045                 1050             


Thr Lys  Glu Ile Gly Ile Gly  Leu Gln Thr Thr Ala  Ala Val Ser 
    1055                 1060                 1065             


Ser Val  Ser Thr Asp His Leu  Cys Cys Gly Ser Leu  Gly Leu Met 
    1070                 1075                 1080             


Val Leu  Leu Glu Met Leu Ser  Ala Gly Pro Trp Pro  Ile Asp Asn 
    1085                 1090                 1095             


Gln Leu  Arg Ser His Cys Gln  Asp Val Ala Phe Gln  Tyr Arg Leu 
    1100                 1105                 1110             


Gln Ala  Leu Gln Arg Cys Ser  Ala Glu Pro Ile Lys  Leu Arg Cys 
    1115                 1120                 1125             


Phe Gly  Thr Lys Glu Gly Leu  Leu Val Leu Pro Gly  Phe Phe Thr 
    1130                 1135                 1140             


Gly Leu  Ser Gly Met Gly Leu  Ala Leu Leu Glu Asp  Asp Pro Ser 
    1145                 1150                 1155             


Arg Ala  Val Val Ser Gln Leu  Ile Ser Ala Gly Leu  Trp Pro Thr 
    1160                 1165                 1170             


Glu 
    


<210>  86
<211>  1162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  86

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu Asp Leu Asn Thr 
        35                  40                  45              


His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Asp Val Ala Gly Gly 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Thr 
                85                  90                  95      


Ser Pro Thr Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala Pro Asp 
            100                 105                 110         


Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu Ser Glu 
        115                 120                 125             


Glu Asn Phe Phe Ala Ala Leu Asn Ser Ala Pro Thr Ser Leu Glu Glu 
    130                 135                 140                 


Asp Asp Pro Cys Phe Asp Glu Ala Leu Gln Asp Ala Leu Glu Ala Leu 
145                 150                 155                 160 


Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Thr Val Asn 
                165                 170                 175     


Arg Pro Phe Val Asp Leu Trp Trp Pro Ile Arg Cys His Ser Ala Glu 
            180                 185                 190         


Ser Leu Arg Gln Ile Phe Val Ser Asp Ser Ala Gly Leu Ala Asp Glu 
        195                 200                 205             


Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys Ala Leu 
    210                 215                 220                 


Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr Pro Gly 
225                 230                 235                 240 


Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser Gly Pro 
                245                 250                 255     


Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg Arg Asn 
            260                 265                 270         


Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg Leu Ile 
        275                 280                 285             


Asp Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met Leu Gln 
    290                 295                 300                 


Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Gly Phe Ala Ile Pro 
305                 310                 315                 320 


Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp Pro His 
                325                 330                 335     


Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro Asn Ser 
            340                 345                 350         


Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp Met Ala 
        355                 360                 365             


Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Ala His Ser 
    370                 375                 380                 


Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asp Gly Tyr 
385                 390                 395                 400 


Gly Tyr Met Glu His Val Val His His Phe Cys Ala Asn Asp Lys Glu 
                405                 410                 415     


Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu Leu His 
            420                 425                 430         


Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly 
        435                 440                 445             


Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu 
    450                 455                 460                 


Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro Glu Pro 
465                 470                 475                 480 


Ser Thr Leu Gln Arg Gln Phe Gln Arg Ser Val Leu Arg Ser Gly Leu 
                485                 490                 495     


Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Gln Ala Ile Asp Ile 
            500                 505                 510         


Ser Ala Leu Gly Ile Ser Pro Pro Asn Lys Pro Glu Arg Ile Ala Ala 
        515                 520                 525             


Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg Val Ser 
    530                 535                 540                 


Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Ala Asp Val 
545                 550                 555                 560 


Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe Ser Met 
                565                 570                 575     


Gln Ser Lys Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp Leu Asn 
            580                 585                 590         


Gly Ile Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val Leu Arg 
        595                 600                 605             


Ala Thr Arg Val Tyr Phe Asn Ile Gln Arg Gln Gln Leu Glu Pro Thr 
    610                 615                 620                 


Ala Leu Arg Ser Ser Leu Ala Gln Ala Leu Lys Leu Glu Gln Leu Ala 
625                 630                 635                 640 


Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro Ile Phe 
                645                 650                 655     


Ala Ala Glu Val Lys Gln Met Gln Gln Leu Asp Ile Pro Phe Phe Thr 
            660                 665                 670         


His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu Gln Glu 
        675                 680                 685             


Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr Glu Arg 
    690                 695                 700                 


Leu Arg Asn Leu Asp Ser Asn Glu Ile Ala Phe Gln Leu Arg Leu Ile 
705                 710                 715                 720 


His Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu Ser Ser 
                725                 730                 735     


Pro Thr Leu His Pro Pro Ala Thr Pro Glu Ala Leu Met Ser Ala Ser 
            740                 745                 750         


Ala Glu Thr Ser Leu Lys Ala Ala Lys Arg Ile Ala His Arg Leu Leu 
        755                 760                 765             


Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu Gly Met 
    770                 775                 780                 


Asp Leu Gly Ala Asp Gly Glu Ser Phe Ala Phe Gly Pro Val Gly Leu 
785                 790                 795                 800 


Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ser His Leu Leu Gln Arg Leu 
                805                 810                 815     


Gln Ala Gln Gln Val Pro Leu Met Asp Ala Asp Ala Ile Gln Thr Ala 
            820                 825                 830         


Ile Leu Gln Pro Leu Val Gly Leu Val Ala Gln Pro Ser Asp Asp Gly 
        835                 840                 845             


Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly 
    850                 855                 860                 


Gly Thr Leu Leu Ala Leu Ala Leu Gln Gly Glu Gln Ala Met Ala Asn 
865                 870                 875                 880 


Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln 
                885                 890                 895     


Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln 
            900                 905                 910         


Leu Gly Thr Glu Ser Ala Leu Gln Trp Ala Leu Arg Ala Gly Asp His 
        915                 920                 925             


Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser 
    930                 935                 940                 


Gln Pro Ala Leu Leu Gly Phe Ser His Gly Val Ala Gly Tyr Ala Ala 
945                 950                 955                 960 


Ala Leu Ala His Leu His Ala Phe Ser Gly Asp Glu Arg Tyr Arg Ile 
                965                 970                 975     


Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp 
            980                 985                 990         


Ala Gly Asn Trp Pro Asp Tyr Arg  Ser Ile Ser Arg Asp  Ser Asp Ser 
        995                 1000                 1005             


Asp Glu  Pro Ser Phe Met Ala  Ser Trp Cys His Gly  Ala Pro Gly 
    1010                 1015                 1020             


Ile Ala  Leu Gly Arg Ala Cys  Leu Trp Gly Thr Ala  Leu Trp Asp 
    1025                 1030                 1035             


Glu Glu  Cys Thr Lys Glu Ile  Gly Ile Gly Leu Gln  Thr Thr Ala 
    1040                 1045                 1050             


Ala Val  Ser Ala Val Ser Thr  Asp His Leu Cys Cys  Gly Ser Leu 
    1055                 1060                 1065             


Gly Leu  Met Val Leu Leu Glu  Met Leu Ser Lys Gly  Pro Trp Pro 
    1070                 1075                 1080             


Ile Asp  Asn Gln Leu Arg Ser  His Cys Gln Asp Val  Ala Ser Gln 
    1085                 1090                 1095             


Tyr Arg  Leu Gln Ala Leu Gln  Arg Cys Ser Ala Glu  Pro Ile Lys 
    1100                 1105                 1110             


Leu Arg  Cys Phe Gly Thr Lys  Glu Gly Leu Leu Val  Leu Pro Gly 
    1115                 1120                 1125             


Phe Phe  Thr Gly Leu Ser Gly  Met Gly Leu Ala Leu  Leu Glu Asp 
    1130                 1135                 1140             


Asp Pro  Ser Arg Ala Val Val  Ser Gln Leu Ile Ser  Ala Gly Leu 
    1145                 1150                 1155             


Trp Pro  Thr Glu 
    1160         


<210>  87
<211>  1162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  87

Met Thr Ser Pro Thr Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Ala Pro Thr Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Asp Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Thr 
65                  70                  75                  80  


Val Asn Arg Pro Phe Val Asp Leu Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ile Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Asp Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Gly Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Ala 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asp 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Phe Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Glu Pro Ser Thr Leu Gln Arg Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Gln Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Ile Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Ala Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Ala 
    450                 455                 460                 


Asp Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Lys Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Leu Asn Gly Ile Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Asn Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Ser Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Ala Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln Gln Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Ser Asn Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile His Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu His Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ala Ser Ala Glu Thr Ser Leu Lys Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ala Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ser His Leu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Gln Gln Val Pro Leu Met Asp Ala Asp Ala Ile Gln 
                725                 730                 735     


Thr Ala Ile Leu Gln Pro Leu Val Gly Leu Val Ala Gln Pro Ser Asp 
            740                 745                 750         


Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly 
        755                 760                 765             


Cys Gly Gly Thr Leu Leu Ala Leu Ala Leu Gln Gly Glu Gln Ala Met 
    770                 775                 780                 


Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp 
785                 790                 795                 800 


Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu 
                805                 810                 815     


Val Gln Leu Gly Thr Glu Ser Ala Leu Gln Trp Ala Leu Arg Ala Gly 
            820                 825                 830         


Asp His Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser 
        835                 840                 845             


Ser Ser Gln Pro Ala Leu Leu Gly Phe Ser His Gly Val Ala Gly Tyr 
    850                 855                 860                 


Ala Ala Ala Leu Ala His Leu His Ala Phe Ser Gly Asp Glu Arg Tyr 
865                 870                 875                 880 


Arg Ile Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn 
                885                 890                 895     


Lys Asp Ala Gly Asn Trp Pro Asp Tyr Arg Ser Ile Ser Arg Asp Ser 
            900                 905                 910         


Asp Ser Asp Glu Pro Ser Phe Met Ala Ser Trp Cys His Gly Ala Pro 
        915                 920                 925             


Gly Ile Ala Leu Gly Arg Ala Cys Leu Trp Gly Thr Ala Leu Trp Asp 
    930                 935                 940                 


Glu Glu Cys Thr Lys Glu Ile Gly Ile Gly Leu Gln Thr Thr Ala Ala 
945                 950                 955                 960 


Val Ser Ala Val Ser Thr Asp His Leu Cys Cys Gly Ser Leu Gly Leu 
                965                 970                 975     


Met Val Leu Leu Glu Met Leu Ser Lys Gly Pro Trp Pro Ile Asp Asn 
            980                 985                 990         


Gln Leu Arg Ser His Cys Gln Asp  Val Ala Ser Gln Tyr  Arg Leu Gln 
        995                 1000                 1005             


Ala Leu  Gln Arg Cys Ser Ala  Glu Pro Ile Lys Leu  Arg Cys Phe 
    1010                 1015                 1020             


Gly Thr  Lys Glu Gly Leu Leu  Val Leu Pro Gly Phe  Phe Thr Gly 
    1025                 1030                 1035             


Leu Ser  Gly Met Gly Leu Ala  Leu Leu Glu Asp Asp  Pro Ser Arg 
    1040                 1045                 1050             


Ala Val  Val Ser Gln Leu Ile  Ser Ala Gly Leu Trp  Pro Thr Glu 
    1055                 1060                 1065             


Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Gly 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser 
    1085                 1090                 1095             


Met Ser  Glu Glu Gln Leu Lys  Ala Phe Ile Ala Lys  Val Gln Ala 
    1100                 1105                 1110             


Asp Ser  Ser Leu Gln Glu Gln  Leu Lys Ala Glu Gly  Ala Asp Val 
    1115                 1120                 1125             


Val Ala  Ile Ala Lys Ala Ala  Gly Phe Ser Ile Thr  Thr Glu Asp 
    1130                 1135                 1140             


Leu Asn  Thr His Arg Gln Asn  Leu Ser Asp Asp Glu  Leu Glu Asp 
    1145                 1150                 1155             


Val Ala  Gly Gly 
    1160         


<210>  88
<211>  1162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  88

Met Thr Ser Pro Thr Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Ala Pro Thr Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Asp Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Thr 
65                  70                  75                  80  


Val Asn Arg Pro Phe Val Asp Leu Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ile Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Asp Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Gly Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Ala 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asp 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Phe Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Glu Pro Ser Thr Leu Gln Arg Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Gln Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Ile Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Ala Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Ala 
    450                 455                 460                 


Asp Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Lys Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Leu Asn Gly Ile Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Asn Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Ser Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Ala Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln Gln Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Ser Asn Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile His Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu His Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ala Ser Ala Glu Thr Ser Leu Lys Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ala Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                725                 730                 735     


Gly Ser Gly Ser Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys 
            740                 745                 750         


Val Gln Ala Asp Ser Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala 
        755                 760                 765             


Asp Val Val Ala Ile Ala Lys Ala Ala Gly Phe Ser Ile Thr Thr Glu 
    770                 775                 780                 


Asp Leu Asn Thr His Arg Gln Asn Leu Ser Asp Asp Glu Leu Glu Asp 
785                 790                 795                 800 


Val Ala Gly Gly Gly Ser Ile Gly Ile Ser His Leu Leu Gln Arg Leu 
                805                 810                 815     


Gln Ala Gln Gln Val Pro Leu Met Asp Ala Asp Ala Ile Gln Thr Ala 
            820                 825                 830         


Ile Leu Gln Pro Leu Val Gly Leu Val Ala Gln Pro Ser Asp Asp Gly 
        835                 840                 845             


Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly 
    850                 855                 860                 


Gly Thr Leu Leu Ala Leu Ala Leu Gln Gly Glu Gln Ala Met Ala Asn 
865                 870                 875                 880 


Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln 
                885                 890                 895     


Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln 
            900                 905                 910         


Leu Gly Thr Glu Ser Ala Leu Gln Trp Ala Leu Arg Ala Gly Asp His 
        915                 920                 925             


Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser 
    930                 935                 940                 


Gln Pro Ala Leu Leu Gly Phe Ser His Gly Val Ala Gly Tyr Ala Ala 
945                 950                 955                 960 


Ala Leu Ala His Leu His Ala Phe Ser Gly Asp Glu Arg Tyr Arg Ile 
                965                 970                 975     


Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp 
            980                 985                 990         


Ala Gly Asn Trp Pro Asp Tyr Arg  Ser Ile Ser Arg Asp  Ser Asp Ser 
        995                 1000                 1005             


Asp Glu  Pro Ser Phe Met Ala  Ser Trp Cys His Gly  Ala Pro Gly 
    1010                 1015                 1020             


Ile Ala  Leu Gly Arg Ala Cys  Leu Trp Gly Thr Ala  Leu Trp Asp 
    1025                 1030                 1035             


Glu Glu  Cys Thr Lys Glu Ile  Gly Ile Gly Leu Gln  Thr Thr Ala 
    1040                 1045                 1050             


Ala Val  Ser Ala Val Ser Thr  Asp His Leu Cys Cys  Gly Ser Leu 
    1055                 1060                 1065             


Gly Leu  Met Val Leu Leu Glu  Met Leu Ser Lys Gly  Pro Trp Pro 
    1070                 1075                 1080             


Ile Asp  Asn Gln Leu Arg Ser  His Cys Gln Asp Val  Ala Ser Gln 
    1085                 1090                 1095             


Tyr Arg  Leu Gln Ala Leu Gln  Arg Cys Ser Ala Glu  Pro Ile Lys 
    1100                 1105                 1110             


Leu Arg  Cys Phe Gly Thr Lys  Glu Gly Leu Leu Val  Leu Pro Gly 
    1115                 1120                 1125             


Phe Phe  Thr Gly Leu Ser Gly  Met Gly Leu Ala Leu  Leu Glu Asp 
    1130                 1135                 1140             


Asp Pro  Ser Arg Ala Val Val  Ser Gln Leu Ile Ser  Ala Gly Leu 
    1145                 1150                 1155             


Trp Pro  Thr Glu 
    1160         


<210>  89
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  89

Met Ser Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp 
1               5                   10                  15      


Ser Ser Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Asn Asp Ala Val 
            20                  25                  30          


Thr Ala Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu 
        35                  40                  45              


Lys Asn Ala Gln Ser Glu Leu Ser Asp Glu Glu Leu Glu Gly Val Ala 
    50                  55                  60                  


Gly Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                85                  90                  95      


Met Arg Glu Asn Trp Lys Gln Gln Trp Leu Asp Ile Val Ala Pro Asp 
            100                 105                 110         


Glu Pro His Lys Leu Ser Arg Arg Leu Asp Trp Asp Glu Leu Thr Glu 
        115                 120                 125             


Glu Glu Phe Arg Glu His Leu Ser Thr Ser Pro Thr Lys Ala Asn Arg 
    130                 135                 140                 


Phe Glu Gly His Trp Gln Asn Cys Leu Asn Glu Cys Arg Leu Ala Ile 
145                 150                 155                 160 


Gln Lys Ala Trp Glu Gln Pro Leu Leu Pro Ile Ser Pro Asp Asn Gln 
                165                 170                 175     


Gln Arg Pro Phe Glu Asp Leu Trp Arg Pro Ile Cys Asn Glu Ala Arg 
            180                 185                 190         


Glu Ile Leu Lys Lys Arg Leu Ser Arg Leu Asp Gly Val Gly Glu Gly 
        195                 200                 205             


Ile Phe Glu Gln Leu Thr Asn Ser Leu Leu Asn Arg Leu Cys Ser Ile 
    210                 215                 220                 


Gly Glu Gln Val Leu Trp Glu Lys Phe Asn Ser Glu Arg Ser Pro Gly 
225                 230                 235                 240 


Val Met Leu Leu Ala His Leu Gly Ser Asn Gly Asp Gly Ser Gly Pro 
                245                 250                 255     


Pro Val Arg Glu Gly Tyr Glu Gln Phe Ile Arg Asn His Arg Gln Asp 
            260                 265                 270         


Gly Leu Thr Gln Leu Leu Gly Glu Phe Pro Glu Leu Gly Arg Leu Ile 
        275                 280                 285             


Gly Thr Ile Val Leu Leu Trp Leu Glu Gly Ser Gln Glu Met Leu Glu 
    290                 295                 300                 


Arg Ile Asp Gln Asp Arg Gln Thr Leu Glu Thr Leu Phe Gly Ile Pro 
305                 310                 315                 320 


Lys Asn Ala Pro Leu Gln Thr Ile His Gln Gly Leu Ser Asp Pro His 
                325                 330                 335     


Arg Gly Gly Arg Ala Val Ala Ile Leu Gly Phe Ala Gly Pro Gly Glu 
            340                 345                 350         


Glu Gln Tyr Lys Leu Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala 
        355                 360                 365             


Ala Tyr Gln Asp Leu Leu Lys Asp Ile Asn Arg Ser Ser Ser Asp Lys 
    370                 375                 380                 


Pro Leu Lys Ile Leu Lys Ile His Asn Gly Glu Gly Tyr Gly Tyr Met 
385                 390                 395                 400 


Glu Tyr Val Ser His Lys Pro Ala Arg Asp Asp Lys Glu Leu Gly Phe 
                405                 410                 415     


Phe Tyr Lys Asn Ala Gly Arg Leu Thr Ala Val Leu His Leu Leu Gly 
            420                 425                 430         


Cys Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu 
        435                 440                 445             


Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Glu Leu Pro Asn His 
    450                 455                 460                 


Ile Asn Asn Asp Thr Ser Glu Ala Pro Glu Leu Ser Ala Leu Gln Lys 
465                 470                 475                 480 


Arg Cys Gln Arg Ser Ile Leu Arg Ser Gly Leu Met Pro Gln Trp Met 
                485                 490                 495     


Phe Leu Gly Ser Glu Lys Ile Ala Ile Asp Ile Ser Ala Leu Gly Ile 
            500                 505                 510         


Ser Pro Pro Lys Gln Glu Thr Gln Lys Thr Ser Gly Trp Leu Gly Leu 
        515                 520                 525             


Asn Ser Asp Gly Met Met Pro Gly Val Ile Glu Arg Asn Ala Asp Leu 
    530                 535                 540                 


Pro Thr Ser Leu Pro Ile Gly Ile Gly Ser Pro Asn Pro Phe Ser Leu 
545                 550                 555                 560 


His Leu Asp Thr Phe Cys Glu Gly Phe Arg Glu Gln Asn Gln Thr Leu 
                565                 570                 575     


Ile Glu Gln Lys Asp Gln Trp Leu Lys Glu Gly Thr Phe Leu Asn Arg 
            580                 585                 590         


Phe Lys Gly Leu Arg Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr 
        595                 600                 605             


Phe Ala Ile Gln Arg Gln Gln Leu Glu Pro Ala Ala Leu Arg Ser Pro 
    610                 615                 620                 


Leu Ile Gln Ala Ile Lys Leu Glu Gln Leu Ser Arg Ser Phe Leu Leu 
625                 630                 635                 640 


Ala Glu Gln Lys Pro Leu His Trp Pro Val Phe Ala Ala Glu Leu Glu 
                645                 650                 655     


Gln Met Gln Gln Leu Asp Ile Pro Phe Phe Thr His Gln Ile Asp Ser 
            660                 665                 670         


Asp Ala Leu Asp Leu Asn Gln Ala Gln Thr Gln Leu Pro Gly Tyr Ile 
        675                 680                 685             


Glu Thr Ser Gly Leu Ser Ala Ala Lys Glu Arg Leu Glu Gln Leu Asp 
    690                 695                 700                 


Thr Ser Glu Val Glu Phe Gln Ile Lys Leu Ile Arg Gly Thr Cys Asn 
705                 710                 715                 720 


Ala Gln Lys Ile Arg Arg Gly Ala Ser Val Glu Thr Ser Val His Ser 
                725                 730                 735     


Ala Gln Glu Asn Gln Tyr Thr Thr Gln Thr Lys Ser Ala Ala Asp His 
            740                 745                 750         


Gln Val Ala Ala Thr Asn Val Met Asn Cys Leu Ala Asp Leu Ala Ile 
        755                 760                 765             


Glu Asp Asn Ser Gly Gln Met Glu Trp Leu Gly Met Asp Leu Gly Ala 
    770                 775                 780                 


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Phe Ser Leu Tyr Gly 
785                 790                 795                 800 


Gly Ser Ser Gly Val Ala Ile Leu Asp His Thr Leu Gln Arg Leu Asn 
                805                 810                 815     


Gly Thr Asn Ser Gln Leu Ser Ala Ile Gln Ser Gly Val Leu Gln Ser 
            820                 825                 830         


Ile Gln Gln Leu Ala Glu Lys Ala Ser Glu Asp Gln Arg Leu Arg Trp 
        835                 840                 845             


Trp Arg Asp Gln Ser Leu Gly Leu Ser Gly Cys Gly Gly Met Leu Leu 
    850                 855                 860                 


Thr Leu Gln Cys Leu Gly Gln Thr Ser Trp Ala Gln Ser Leu Leu Lys 
865                 870                 875                 880 


Ser Gly Arg Gln Arg Phe Leu Glu Ala Asp Arg Gln Leu Asp Leu Ile 
                885                 890                 895     


Gly Gly Cys Thr Gly Leu Ile Gly Pro Leu Leu His Leu Lys Ser Pro 
            900                 905                 910         


Glu Ala Leu Asp Leu Ala Ile His Ala Gly Lys His Leu Leu Glu Gln 
        915                 920                 925             


Gln Gln Glu Asp Gly Ser Trp Pro Gly Arg Ala Lys Asn Thr Pro Gly 
    930                 935                 940                 


Leu Leu Gly Phe Ser His Gly Thr Ala Gly His Ala Ala Ala Leu Ala 
945                 950                 955                 960 


Lys Leu His Gln Ala Thr His Asp Asn Arg Phe Leu Glu Gly Ala Lys 
                965                 970                 975     


Ala Ala Leu His His Glu Arg Ala His Phe Asp Ser Lys Glu Glu Asn 
            980                 985                 990         


Trp Pro Asp Phe Arg Asp Ile Thr  Gln Ser Gly Ser Phe  Met Thr Ser 
        995                 1000                 1005             


Trp Cys  His Gly Ala Pro Gly  Ile Gly Ile Ala Arg  Ala Cys Leu 
    1010                 1015                 1020             


Trp Gln  Thr Glu Leu Trp Asp  Glu Gln Cys Arg Asp  Glu Ile His 
    1025                 1030                 1035             


Ala Ala  Ile Arg Thr Thr Ser  Lys Ser Ile Gly Gln  Leu Arg Ser 
    1040                 1045                 1050             


Asp His  Leu Cys Cys Gly Lys  Ala Gly Leu Ala Ile  Ile Leu Glu 
    1055                 1060                 1065             


Met Leu  Cys Asp Gly Pro Trp  Gly Val Glu Ala His  Val Ala Asp 
    1070                 1075                 1080             


Leu Ala  Arg Glu Arg Thr Ile  Gln Ile His Thr Ser  Leu Met Asn 
    1085                 1090                 1095             


Arg Thr  Ser Ser Lys Met Pro  Asp Leu Ile Cys Phe  Ala Ala Lys 
    1100                 1105                 1110             


Glu Thr  Ser Leu Val Leu Pro  Gly Phe Phe Thr Gly  Leu Ser Gly 
    1115                 1120                 1125             


Ile Gly  Met Ala Leu Leu Arg  Asp Asp Gln Ser Lys  Gln Thr Thr 
    1130                 1135                 1140             


Arg Arg  Leu Leu Thr Ala Gly  Leu Trp Thr Glu 
    1145                 1150                 


<210>  90
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  90

Met Arg Glu Asn Trp Lys Gln Gln Trp Leu Asp Ile Val Ala Pro Asp 
1               5                   10                  15      


Glu Pro His Lys Leu Ser Arg Arg Leu Asp Trp Asp Glu Leu Thr Glu 
            20                  25                  30          


Glu Glu Phe Arg Glu His Leu Ser Thr Ser Pro Thr Lys Ala Asn Arg 
        35                  40                  45              


Phe Glu Gly His Trp Gln Asn Cys Leu Asn Glu Cys Arg Leu Ala Ile 
    50                  55                  60                  


Gln Lys Ala Trp Glu Gln Pro Leu Leu Pro Ile Ser Pro Asp Asn Gln 
65                  70                  75                  80  


Gln Arg Pro Phe Glu Asp Leu Trp Arg Pro Ile Cys Asn Glu Ala Arg 
                85                  90                  95      


Glu Ile Leu Lys Lys Arg Leu Ser Arg Leu Asp Gly Val Gly Glu Gly 
            100                 105                 110         


Ile Phe Glu Gln Leu Thr Asn Ser Leu Leu Asn Arg Leu Cys Ser Ile 
        115                 120                 125             


Gly Glu Gln Val Leu Trp Glu Lys Phe Asn Ser Glu Arg Ser Pro Gly 
    130                 135                 140                 


Val Met Leu Leu Ala His Leu Gly Ser Asn Gly Asp Gly Ser Gly Pro 
145                 150                 155                 160 


Pro Val Arg Glu Gly Tyr Glu Gln Phe Ile Arg Asn His Arg Gln Asp 
                165                 170                 175     


Gly Leu Thr Gln Leu Leu Gly Glu Phe Pro Glu Leu Gly Arg Leu Ile 
            180                 185                 190         


Gly Thr Ile Val Leu Leu Trp Leu Glu Gly Ser Gln Glu Met Leu Glu 
        195                 200                 205             


Arg Ile Asp Gln Asp Arg Gln Thr Leu Glu Thr Leu Phe Gly Ile Pro 
    210                 215                 220                 


Lys Asn Ala Pro Leu Gln Thr Ile His Gln Gly Leu Ser Asp Pro His 
225                 230                 235                 240 


Arg Gly Gly Arg Ala Val Ala Ile Leu Gly Phe Ala Gly Pro Gly Glu 
                245                 250                 255     


Glu Gln Tyr Lys Leu Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala 
            260                 265                 270         


Ala Tyr Gln Asp Leu Leu Lys Asp Ile Asn Arg Ser Ser Ser Asp Lys 
        275                 280                 285             


Pro Leu Lys Ile Leu Lys Ile His Asn Gly Glu Gly Tyr Gly Tyr Met 
    290                 295                 300                 


Glu Tyr Val Ser His Lys Pro Ala Arg Asp Asp Lys Glu Leu Gly Phe 
305                 310                 315                 320 


Phe Tyr Lys Asn Ala Gly Arg Leu Thr Ala Val Leu His Leu Leu Gly 
                325                 330                 335     


Cys Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu 
            340                 345                 350         


Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Glu Leu Pro Asn His 
        355                 360                 365             


Ile Asn Asn Asp Thr Ser Glu Ala Pro Glu Leu Ser Ala Leu Gln Lys 
    370                 375                 380                 


Arg Cys Gln Arg Ser Ile Leu Arg Ser Gly Leu Met Pro Gln Trp Met 
385                 390                 395                 400 


Phe Leu Gly Ser Glu Lys Ile Ala Ile Asp Ile Ser Ala Leu Gly Ile 
                405                 410                 415     


Ser Pro Pro Lys Gln Glu Thr Gln Lys Thr Ser Gly Trp Leu Gly Leu 
            420                 425                 430         


Asn Ser Asp Gly Met Met Pro Gly Val Ile Glu Arg Asn Ala Asp Leu 
        435                 440                 445             


Pro Thr Ser Leu Pro Ile Gly Ile Gly Ser Pro Asn Pro Phe Ser Leu 
    450                 455                 460                 


His Leu Asp Thr Phe Cys Glu Gly Phe Arg Glu Gln Asn Gln Thr Leu 
465                 470                 475                 480 


Ile Glu Gln Lys Asp Gln Trp Leu Lys Glu Gly Thr Phe Leu Asn Arg 
                485                 490                 495     


Phe Lys Gly Leu Arg Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr 
            500                 505                 510         


Phe Ala Ile Gln Arg Gln Gln Leu Glu Pro Ala Ala Leu Arg Ser Pro 
        515                 520                 525             


Leu Ile Gln Ala Ile Lys Leu Glu Gln Leu Ser Arg Ser Phe Leu Leu 
    530                 535                 540                 


Ala Glu Gln Lys Pro Leu His Trp Pro Val Phe Ala Ala Glu Leu Glu 
545                 550                 555                 560 


Gln Met Gln Gln Leu Asp Ile Pro Phe Phe Thr His Gln Ile Asp Ser 
                565                 570                 575     


Asp Ala Leu Asp Leu Asn Gln Ala Gln Thr Gln Leu Pro Gly Tyr Ile 
            580                 585                 590         


Glu Thr Ser Gly Leu Ser Ala Ala Lys Glu Arg Leu Glu Gln Leu Asp 
        595                 600                 605             


Thr Ser Glu Val Glu Phe Gln Ile Lys Leu Ile Arg Gly Thr Cys Asn 
    610                 615                 620                 


Ala Gln Lys Ile Arg Arg Gly Ala Ser Val Glu Thr Ser Val His Ser 
625                 630                 635                 640 


Ala Gln Glu Asn Gln Tyr Thr Thr Gln Thr Lys Ser Ala Ala Asp His 
                645                 650                 655     


Gln Val Ala Ala Thr Asn Val Met Asn Cys Leu Ala Asp Leu Ala Ile 
            660                 665                 670         


Glu Asp Asn Ser Gly Gln Met Glu Trp Leu Gly Met Asp Leu Gly Ala 
        675                 680                 685             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Phe Ser Leu Tyr Gly 
    690                 695                 700                 


Gly Ser Ser Gly Val Ala Ile Leu Asp His Thr Leu Gln Arg Leu Asn 
705                 710                 715                 720 


Gly Thr Asn Ser Gln Leu Ser Ala Ile Gln Ser Gly Val Leu Gln Ser 
                725                 730                 735     


Ile Gln Gln Leu Ala Glu Lys Ala Ser Glu Asp Gln Arg Leu Arg Trp 
            740                 745                 750         


Trp Arg Asp Gln Ser Leu Gly Leu Ser Gly Cys Gly Gly Met Leu Leu 
        755                 760                 765             


Thr Leu Gln Cys Leu Gly Gln Thr Ser Trp Ala Gln Ser Leu Leu Lys 
    770                 775                 780                 


Ser Gly Arg Gln Arg Phe Leu Glu Ala Asp Arg Gln Leu Asp Leu Ile 
785                 790                 795                 800 


Gly Gly Cys Thr Gly Leu Ile Gly Pro Leu Leu His Leu Lys Ser Pro 
                805                 810                 815     


Glu Ala Leu Asp Leu Ala Ile His Ala Gly Lys His Leu Leu Glu Gln 
            820                 825                 830         


Gln Gln Glu Asp Gly Ser Trp Pro Gly Arg Ala Lys Asn Thr Pro Gly 
        835                 840                 845             


Leu Leu Gly Phe Ser His Gly Thr Ala Gly His Ala Ala Ala Leu Ala 
    850                 855                 860                 


Lys Leu His Gln Ala Thr His Asp Asn Arg Phe Leu Glu Gly Ala Lys 
865                 870                 875                 880 


Ala Ala Leu His His Glu Arg Ala His Phe Asp Ser Lys Glu Glu Asn 
                885                 890                 895     


Trp Pro Asp Phe Arg Asp Ile Thr Gln Ser Gly Ser Phe Met Thr Ser 
            900                 905                 910         


Trp Cys His Gly Ala Pro Gly Ile Gly Ile Ala Arg Ala Cys Leu Trp 
        915                 920                 925             


Gln Thr Glu Leu Trp Asp Glu Gln Cys Arg Asp Glu Ile His Ala Ala 
    930                 935                 940                 


Ile Arg Thr Thr Ser Lys Ser Ile Gly Gln Leu Arg Ser Asp His Leu 
945                 950                 955                 960 


Cys Cys Gly Lys Ala Gly Leu Ala Ile Ile Leu Glu Met Leu Cys Asp 
                965                 970                 975     


Gly Pro Trp Gly Val Glu Ala His Val Ala Asp Leu Ala Arg Glu Arg 
            980                 985                 990         


Thr Ile Gln Ile His Thr Ser Leu  Met Asn Arg Thr Ser  Ser Lys Met 
        995                 1000                 1005             


Pro Asp  Leu Ile Cys Phe Ala  Ala Lys Glu Thr Ser  Leu Val Leu 
    1010                 1015                 1020             


Pro Gly  Phe Phe Thr Gly Leu  Ser Gly Ile Gly Met  Ala Leu Leu 
    1025                 1030                 1035             


Arg Asp  Asp Gln Ser Lys Gln  Thr Thr Arg Arg Leu  Leu Thr Ala 
    1040                 1045                 1050             


Gly Leu  Trp Thr Glu Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser 
    1055                 1060                 1065             


Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Gly 
    1070                 1075                 1080             


Ser Gly  Ser Gly Ser Met Ser  Glu Glu Gln Leu Lys  Ala Phe Leu 
    1085                 1090                 1095             


Glu Lys  Val Lys Gly Asp Ser  Ser Leu Gln Glu Lys  Leu Lys Ala 
    1100                 1105                 1110             


Ala Ala  Asp Asn Asp Ala Val  Thr Ala Ile Ala Lys  Glu Ala Gly 
    1115                 1120                 1125             


Phe Ser  Ile Ser Ala Asp Asp  Leu Lys Asn Ala Gln  Ser Glu Leu 
    1130                 1135                 1140             


Ser Asp  Glu Glu Leu Glu Gly  Val Ala Gly Gly 
    1145                 1150                 


<210>  91
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  91

Met Arg Glu Asn Trp Lys Gln Gln Trp Leu Asp Ile Val Ala Pro Asp 
1               5                   10                  15      


Glu Pro His Lys Leu Ser Arg Arg Leu Asp Trp Asp Glu Leu Thr Glu 
            20                  25                  30          


Glu Glu Phe Arg Glu His Leu Ser Thr Ser Pro Thr Lys Ala Asn Arg 
        35                  40                  45              


Phe Glu Gly His Trp Gln Asn Cys Leu Asn Glu Cys Arg Leu Ala Ile 
    50                  55                  60                  


Gln Lys Ala Trp Glu Gln Pro Leu Leu Pro Ile Ser Pro Asp Asn Gln 
65                  70                  75                  80  


Gln Arg Pro Phe Glu Asp Leu Trp Arg Pro Ile Cys Asn Glu Ala Arg 
                85                  90                  95      


Glu Ile Leu Lys Lys Arg Leu Ser Arg Leu Asp Gly Val Gly Glu Gly 
            100                 105                 110         


Ile Phe Glu Gln Leu Thr Asn Ser Leu Leu Asn Arg Leu Cys Ser Ile 
        115                 120                 125             


Gly Glu Gln Val Leu Trp Glu Lys Phe Asn Ser Glu Arg Ser Pro Gly 
    130                 135                 140                 


Val Met Leu Leu Ala His Leu Gly Ser Asn Gly Asp Gly Ser Gly Pro 
145                 150                 155                 160 


Pro Val Arg Glu Gly Tyr Glu Gln Phe Ile Arg Asn His Arg Gln Asp 
                165                 170                 175     


Gly Leu Thr Gln Leu Leu Gly Glu Phe Pro Glu Leu Gly Arg Leu Ile 
            180                 185                 190         


Gly Thr Ile Val Leu Leu Trp Leu Glu Gly Ser Gln Glu Met Leu Glu 
        195                 200                 205             


Arg Ile Asp Gln Asp Arg Gln Thr Leu Glu Thr Leu Phe Gly Ile Pro 
    210                 215                 220                 


Lys Asn Ala Pro Leu Gln Thr Ile His Gln Gly Leu Ser Asp Pro His 
225                 230                 235                 240 


Arg Gly Gly Arg Ala Val Ala Ile Leu Gly Phe Ala Gly Pro Gly Glu 
                245                 250                 255     


Glu Gln Tyr Lys Leu Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala 
            260                 265                 270         


Ala Tyr Gln Asp Leu Leu Lys Asp Ile Asn Arg Ser Ser Ser Asp Lys 
        275                 280                 285             


Pro Leu Lys Ile Leu Lys Ile His Asn Gly Glu Gly Tyr Gly Tyr Met 
    290                 295                 300                 


Glu Tyr Val Ser His Lys Pro Ala Arg Asp Asp Lys Glu Leu Gly Phe 
305                 310                 315                 320 


Phe Tyr Lys Asn Ala Gly Arg Leu Thr Ala Val Leu His Leu Leu Gly 
                325                 330                 335     


Cys Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu 
            340                 345                 350         


Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Glu Leu Pro Asn His 
        355                 360                 365             


Ile Asn Asn Asp Thr Ser Glu Ala Pro Glu Leu Ser Ala Leu Gln Lys 
    370                 375                 380                 


Arg Cys Gln Arg Ser Ile Leu Arg Ser Gly Leu Met Pro Gln Trp Met 
385                 390                 395                 400 


Phe Leu Gly Ser Glu Lys Ile Ala Ile Asp Ile Ser Ala Leu Gly Ile 
                405                 410                 415     


Ser Pro Pro Lys Gln Glu Thr Gln Lys Thr Ser Gly Trp Leu Gly Leu 
            420                 425                 430         


Asn Ser Asp Gly Met Met Pro Gly Val Ile Glu Arg Asn Ala Asp Leu 
        435                 440                 445             


Pro Thr Ser Leu Pro Ile Gly Ile Gly Ser Pro Asn Pro Phe Ser Leu 
    450                 455                 460                 


His Leu Asp Thr Phe Cys Glu Gly Phe Arg Glu Gln Asn Gln Thr Leu 
465                 470                 475                 480 


Ile Glu Gln Lys Asp Gln Trp Leu Lys Glu Gly Thr Phe Leu Asn Arg 
                485                 490                 495     


Phe Lys Gly Leu Arg Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr 
            500                 505                 510         


Phe Ala Ile Gln Arg Gln Gln Leu Glu Pro Ala Ala Leu Arg Ser Pro 
        515                 520                 525             


Leu Ile Gln Ala Ile Lys Leu Glu Gln Leu Ser Arg Ser Phe Leu Leu 
    530                 535                 540                 


Ala Glu Gln Lys Pro Leu His Trp Pro Val Phe Ala Ala Glu Leu Glu 
545                 550                 555                 560 


Gln Met Gln Gln Leu Asp Ile Pro Phe Phe Thr His Gln Ile Asp Ser 
                565                 570                 575     


Asp Ala Leu Asp Leu Asn Gln Ala Gln Thr Gln Leu Pro Gly Tyr Ile 
            580                 585                 590         


Glu Thr Ser Gly Leu Ser Ala Ala Lys Glu Arg Leu Glu Gln Leu Asp 
        595                 600                 605             


Thr Ser Glu Val Glu Phe Gln Ile Lys Leu Ile Arg Gly Thr Cys Asn 
    610                 615                 620                 


Ala Gln Lys Ile Arg Arg Gly Ala Ser Val Glu Thr Ser Val His Ser 
625                 630                 635                 640 


Ala Gln Glu Asn Gln Tyr Thr Thr Gln Thr Lys Ser Ala Ala Asp His 
                645                 650                 655     


Gln Val Ala Ala Thr Asn Val Met Asn Cys Leu Ala Asp Leu Ala Ile 
            660                 665                 670         


Glu Asp Asn Ser Gly Gln Met Glu Trp Leu Gly Met Asp Leu Gly Ala 
        675                 680                 685             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Phe Ser Leu Tyr Gly 
    690                 695                 700                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Ser 
                725                 730                 735     


Glu Glu Gln Leu Lys Ala Phe Leu Glu Lys Val Lys Gly Asp Ser Ser 
            740                 745                 750         


Leu Gln Glu Lys Leu Lys Ala Ala Ala Asp Asn Asp Ala Val Thr Ala 
        755                 760                 765             


Ile Ala Lys Glu Ala Gly Phe Ser Ile Ser Ala Asp Asp Leu Lys Asn 
    770                 775                 780                 


Ala Gln Ser Glu Leu Ser Asp Glu Glu Leu Glu Gly Val Ala Gly Gly 
785                 790                 795                 800 


Gly Ser Ser Gly Val Ala Ile Leu Asp His Thr Leu Gln Arg Leu Asn 
                805                 810                 815     


Gly Thr Asn Ser Gln Leu Ser Ala Ile Gln Ser Gly Val Leu Gln Ser 
            820                 825                 830         


Ile Gln Gln Leu Ala Glu Lys Ala Ser Glu Asp Gln Arg Leu Arg Trp 
        835                 840                 845             


Trp Arg Asp Gln Ser Leu Gly Leu Ser Gly Cys Gly Gly Met Leu Leu 
    850                 855                 860                 


Thr Leu Gln Cys Leu Gly Gln Thr Ser Trp Ala Gln Ser Leu Leu Lys 
865                 870                 875                 880 


Ser Gly Arg Gln Arg Phe Leu Glu Ala Asp Arg Gln Leu Asp Leu Ile 
                885                 890                 895     


Gly Gly Cys Thr Gly Leu Ile Gly Pro Leu Leu His Leu Lys Ser Pro 
            900                 905                 910         


Glu Ala Leu Asp Leu Ala Ile His Ala Gly Lys His Leu Leu Glu Gln 
        915                 920                 925             


Gln Gln Glu Asp Gly Ser Trp Pro Gly Arg Ala Lys Asn Thr Pro Gly 
    930                 935                 940                 


Leu Leu Gly Phe Ser His Gly Thr Ala Gly His Ala Ala Ala Leu Ala 
945                 950                 955                 960 


Lys Leu His Gln Ala Thr His Asp Asn Arg Phe Leu Glu Gly Ala Lys 
                965                 970                 975     


Ala Ala Leu His His Glu Arg Ala His Phe Asp Ser Lys Glu Glu Asn 
            980                 985                 990         


Trp Pro Asp Phe Arg Asp Ile Thr  Gln Ser Gly Ser Phe  Met Thr Ser 
        995                 1000                 1005             


Trp Cys  His Gly Ala Pro Gly  Ile Gly Ile Ala Arg  Ala Cys Leu 
    1010                 1015                 1020             


Trp Gln  Thr Glu Leu Trp Asp  Glu Gln Cys Arg Asp  Glu Ile His 
    1025                 1030                 1035             


Ala Ala  Ile Arg Thr Thr Ser  Lys Ser Ile Gly Gln  Leu Arg Ser 
    1040                 1045                 1050             


Asp His  Leu Cys Cys Gly Lys  Ala Gly Leu Ala Ile  Ile Leu Glu 
    1055                 1060                 1065             


Met Leu  Cys Asp Gly Pro Trp  Gly Val Glu Ala His  Val Ala Asp 
    1070                 1075                 1080             


Leu Ala  Arg Glu Arg Thr Ile  Gln Ile His Thr Ser  Leu Met Asn 
    1085                 1090                 1095             


Arg Thr  Ser Ser Lys Met Pro  Asp Leu Ile Cys Phe  Ala Ala Lys 
    1100                 1105                 1110             


Glu Thr  Ser Leu Val Leu Pro  Gly Phe Phe Thr Gly  Leu Ser Gly 
    1115                 1120                 1125             


Ile Gly  Met Ala Leu Leu Arg  Asp Asp Gln Ser Lys  Gln Thr Thr 
    1130                 1135                 1140             


Arg Arg  Leu Leu Thr Ala Gly  Leu Trp Thr Glu 
    1145                 1150                 


<210>  92
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  92

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60                  


Met Ser Leu Ser Arg Asp Val Val Leu Leu Ile Thr His Ser Gly Asp 
65                  70                  75                  80  


Phe Phe Thr Ile Asp Arg Val Ile Glu Ala Leu Leu Lys Lys Gly Val 
                85                  90                  95      


Gln Pro Phe Arg Phe Asp Thr Asp Gln Phe Pro Leu Asn Val Gln Leu 
            100                 105                 110         


Thr Ala Asn Phe Gly Lys Ser Asn Ser Asp His Gln Leu Glu Tyr Asn 
        115                 120                 125             


Gly Asn Ser Ile Ser Thr Lys Gln Val Gln Ala Val Trp Leu Arg Arg 
    130                 135                 140                 


Ile Trp Glu Pro Asp Phe Gln Glu Leu Asp Pro Gln Tyr Gln Gln Ala 
145                 150                 155                 160 


Cys Ala Lys Glu Ser Lys Ala Thr Leu Asn Gly Phe Trp Asp Ser Leu 
                165                 170                 175     


Arg Asp Ala Asn Trp Val Asp His Leu Ala Gln Ile Glu Ala Ala Ser 
            180                 185                 190         


Asn Lys Leu Leu Gln Leu Arg Leu Ala Ser Glu Val Gly Phe Thr Ile 
        195                 200                 205             


Pro Gln Thr Leu Ile Thr Asn Lys Ala Glu Ala Ala Arg Glu Phe Phe 
    210                 215                 220                 


Gln Gln Val Asn Gly Lys Met Val Ser Lys Leu Leu Thr Ala Leu Ser 
225                 230                 235                 240 


Arg Ser Met Glu Ser Thr Ser Phe Phe Leu Tyr Thr Ser Leu Val Lys 
                245                 250                 255     


Glu Glu Tyr Leu Gln Asp Ala Glu Ser Leu Arg Tyr Cys Pro Met Val 
            260                 265                 270         


Phe Gln Glu Gln Ile Phe Lys Gln Gln Glu Leu Arg Val Ile Tyr Val 
        275                 280                 285             


Asn Gly Lys Val Phe Val Gly Ala Leu Asn Ala Ser Val Tyr Glu Asp 
    290                 295                 300                 


Ser Thr Val Asp Trp Arg Ala Pro Gly Ile Glu Val Gly Ala Trp Gln 
305                 310                 315                 320 


Asn His Gln Leu Pro Glu Glu Leu Ile Arg Arg Leu Gln Thr Phe Met 
                325                 330                 335     


Gly Glu Leu Gly Leu Leu Phe Gly Ala Phe Asp Phe Ile Leu Thr Pro 
            340                 345                 350         


Ser Gly Asp Tyr Val Phe Leu Glu Val Asn Pro Gly Gly Glu Trp Gly 
        355                 360                 365             


Met Leu Glu Arg Asp Leu Asp Leu Pro Ile Ser Gln Ala Ile Ala Asp 
    370                 375                 380                 


Thr Leu Ile Pro 
385             


<210>  93
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  93

Met Ser Leu Ser Arg Asp Val Val Leu Leu Ile Thr His Ser Gly Asp 
1               5                   10                  15      


Phe Phe Thr Ile Asp Arg Val Ile Glu Ala Leu Leu Lys Lys Gly Val 
            20                  25                  30          


Gln Pro Phe Arg Phe Asp Thr Asp Gln Phe Pro Leu Asn Val Gln Leu 
        35                  40                  45              


Thr Ala Asn Phe Gly Lys Ser Asn Ser Asp His Gln Leu Glu Tyr Asn 
    50                  55                  60                  


Gly Asn Ser Ile Ser Thr Lys Gln Val Gln Ala Val Trp Leu Arg Arg 
65                  70                  75                  80  


Ile Trp Glu Pro Asp Phe Gln Glu Leu Asp Pro Gln Tyr Gln Gln Ala 
                85                  90                  95      


Cys Ala Lys Glu Ser Lys Ala Thr Leu Asn Gly Phe Trp Asp Ser Leu 
            100                 105                 110         


Arg Asp Ala Asn Trp Val Asp His Leu Ala Gln Ile Glu Ala Ala Ser 
        115                 120                 125             


Asn Lys Leu Leu Gln Leu Arg Leu Ala Ser Glu Val Gly Phe Thr Ile 
    130                 135                 140                 


Pro Gln Thr Leu Ile Thr Asn Lys Ala Glu Ala Ala Arg Glu Phe Phe 
145                 150                 155                 160 


Gln Gln Val Asn Gly Lys Met Val Ser Lys Leu Leu Thr Ala Leu Ser 
                165                 170                 175     


Arg Ser Met Glu Ser Thr Ser Phe Phe Leu Tyr Thr Ser Leu Val Lys 
            180                 185                 190         


Glu Glu Tyr Leu Gln Asp Ala Glu Ser Leu Arg Tyr Cys Pro Met Val 
        195                 200                 205             


Phe Gln Glu Gln Ile Phe Lys Gln Gln Glu Leu Arg Val Ile Tyr Val 
    210                 215                 220                 


Asn Gly Lys Val Phe Val Gly Ala Leu Asn Ala Ser Val Tyr Glu Asp 
225                 230                 235                 240 


Ser Thr Val Asp Trp Arg Ala Pro Gly Ile Glu Val Gly Ala Trp Gln 
                245                 250                 255     


Asn His Gln Leu Pro Glu Glu Leu Ile Arg Arg Leu Gln Thr Phe Met 
            260                 265                 270         


Gly Glu Leu Gly Leu Leu Phe Gly Ala Phe Asp Phe Ile Leu Thr Pro 
        275                 280                 285             


Ser Gly Asp Tyr Val Phe Leu Glu Val Asn Pro Gly Gly Glu Trp Gly 
    290                 295                 300                 


Met Leu Glu Arg Asp Leu Asp Leu Pro Ile Ser Gln Ala Ile Ala Asp 
305                 310                 315                 320 


Thr Leu Ile Pro Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro 
        355                 360                 365             


Phe Phe Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser 
    370                 375                 380                 


Asn Ser Ala Pro 
385             


<210>  94
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  94

Met Ser Leu Ser Arg Asp Val Val Leu Leu Ile Thr His Ser Gly Asp 
1               5                   10                  15      


Phe Phe Thr Ile Asp Arg Val Ile Glu Ala Leu Leu Lys Lys Gly Val 
            20                  25                  30          


Gln Pro Phe Arg Phe Asp Thr Asp Gln Phe Pro Leu Asn Val Gln Leu 
        35                  40                  45              


Thr Ala Asn Phe Gly Lys Ser Asn Ser Asp His Gln Leu Glu Tyr Asn 
    50                  55                  60                  


Gly Asn Ser Ile Ser Thr Lys Gln Val Gln Ala Val Trp Leu Arg Arg 
65                  70                  75                  80  


Ile Trp Glu Pro Asp Phe Gln Glu Leu Asp Pro Gln Tyr Gln Gln Ala 
                85                  90                  95      


Cys Ala Lys Glu Ser Lys Ala Thr Leu Asn Gly Phe Trp Asp Ser Leu 
            100                 105                 110         


Arg Asp Ala Asn Trp Val Asp His Leu Ala Gln Ile Glu Ala Gly Ser 
        115                 120                 125             


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Ser Lys Asn 
145                 150                 155                 160 


Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe Ala Arg Phe Leu 
                165                 170                 175     


Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser Ala Pro Ala Ser 
            180                 185                 190         


Asn Lys Leu Leu Gln Leu Arg Leu Ala Ser Glu Val Gly Phe Thr Ile 
        195                 200                 205             


Pro Gln Thr Leu Ile Thr Asn Lys Ala Glu Ala Ala Arg Glu Phe Phe 
    210                 215                 220                 


Gln Gln Val Asn Gly Lys Met Val Ser Lys Leu Leu Thr Ala Leu Ser 
225                 230                 235                 240 


Arg Ser Met Glu Ser Thr Ser Phe Phe Leu Tyr Thr Ser Leu Val Lys 
                245                 250                 255     


Glu Glu Tyr Leu Gln Asp Ala Glu Ser Leu Arg Tyr Cys Pro Met Val 
            260                 265                 270         


Phe Gln Glu Gln Ile Phe Lys Gln Gln Glu Leu Arg Val Ile Tyr Val 
        275                 280                 285             


Asn Gly Lys Val Phe Val Gly Ala Leu Asn Ala Ser Val Tyr Glu Asp 
    290                 295                 300                 


Ser Thr Val Asp Trp Arg Ala Pro Gly Ile Glu Val Gly Ala Trp Gln 
305                 310                 315                 320 


Asn His Gln Leu Pro Glu Glu Leu Ile Arg Arg Leu Gln Thr Phe Met 
                325                 330                 335     


Gly Glu Leu Gly Leu Leu Phe Gly Ala Phe Asp Phe Ile Leu Thr Pro 
            340                 345                 350         


Ser Gly Asp Tyr Val Phe Leu Glu Val Asn Pro Gly Gly Glu Trp Gly 
        355                 360                 365             


Met Leu Glu Arg Asp Leu Asp Leu Pro Ile Ser Gln Ala Ile Ala Asp 
    370                 375                 380                 


Thr Leu Ile Pro 
385             


<210>  95
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  95

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    50                  55                  60                  


Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
65                  70                  75                  80  


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
                85                  90                  95      


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
            100                 105                 110         


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
        115                 120                 125             


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
    130                 135                 140                 


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
145                 150                 155                 160 


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
                165                 170                 175     


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
            180                 185                 190         


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
        195                 200                 205             


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
    210                 215                 220                 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
225                 230                 235                 240 


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
                245                 250                 255     


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
            260                 265                 270         


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
        275                 280                 285             


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
    290                 295                 300                 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
305                 310                 315                 320 


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
                325                 330                 335     


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
            340                 345                 350         


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
        355                 360                 365             


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
    370                 375                 380                 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe 
385                 390                 


<210>  96
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  96

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
145                 150                 155                 160 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
                165                 170                 175     


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
    210                 215                 220                 


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
                245                 250                 255     


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
        275                 280                 285             


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
305                 310                 315                 320 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Ser Gly Ser Met Ser Lys Asn Val Lys Val Ser 
        355                 360                 365             


Ala Pro Lys Ala Val Pro Phe Phe Ala Arg Phe Leu Ala Glu Gln Ala 
    370                 375                 380                 


Val Glu Ala Asn Asn Ser Asn Ser Ala Pro 
385                 390                 


<210>  97
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  97

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Gly Ser Gly Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Ser Gly Ser Gly Ser Met Ser Lys Asn Val Lys Val Ser Ala 
145                 150                 155                 160 


Pro Lys Ala Val Pro Phe Phe Ala Arg Phe Leu Ala Glu Gln Ala Val 
                165                 170                 175     


Glu Ala Asn Asn Ser Asn Ser Ala Pro Ala Asn Asn Lys Gln Leu Gln 
            180                 185                 190         


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
        195                 200                 205             


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
    210                 215                 220                 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
225                 230                 235                 240 


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
                245                 250                 255     


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
            260                 265                 270         


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
        275                 280                 285             


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
    290                 295                 300                 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
305                 310                 315                 320 


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
                325                 330                 335     


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
            340                 345                 350         


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
        355                 360                 365             


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
    370                 375                 380                 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe 
385                 390                 


<210>  98
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  98

Thr Ile Gly Gly Thr Ile Val Ser Ile Thr Cys Glu Thr Cys Asp Leu 
1               5                   10                  15      


Leu Val Gly Lys Met Cys 
            20          


<210>  99
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X=X(n), wherein X is any amino acid and n=3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X=X(n), wherein X is any amino acid and n=2

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X=X(n), wherein X is any amino acid and n=7

<400>  99

Thr Xaa Thr Xaa Ser Xaa Thr Cys Xaa Thr Cys Xaa Cys 
1               5                   10              


<210>  100
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X=(X)n, wherein X is any amino acid and n=1-100

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X=(X)n, wherein X is any amino acid and n=1-100

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X=(X)n, wherein X is any amino acid and n=1-100

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X=(X)n, wherein X is any amino acid and n=1-100

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X=(X)n, wherein X is any amino acid and n=1-100

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  X=(X)n, wherein X is any amino acid and n=1-100

<400>  100

Thr Xaa Thr Xaa Ser Xaa Thr Cys Xaa Thr Cys Xaa Cys Xaa 
1               5                   10                  


<210>  101
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  101

Ala Ala Cys His Asn His Ala Pro Ser Met Pro Pro Ser Tyr Trp Glu 
1               5                   10                  15      


Gly Glu Cys 
            


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  X=X(n), wherein X is is any amino acid and n=0-100

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X=X(n), wherein X is is any amino acid and n=1-10

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X=X(n), wherein X is is any amino acid and n=0-10

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X=X(n), wherein X is is any amino acid and n=1-10

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X=X(n), wherein X is is any amino acid and n=0-100

<400>  102

Xaa Cys Xaa Ser Xaa Ser Xaa Cys Xaa 
1               5                   


<210>  103
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  103
ctaaacaact ttcaacagtt tctgcggccg ccccgtgcac cgccatggcc ggctgggccg       60

catagaaagg aacaactaaa gg                                                82


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
gcgatggttg ttgtcattgt                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105
attccacaga cagccctcat                                                   20


<210>  106
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oligo

<400>  106

Cys Thr Gly Cys Gly Gly Cys Cys Gly Cys Gly Cys Cys Thr Gly Cys 
1               5                   10                  15      


Gly Cys Ala Ser Asn Asn Ser Asn Asn Ser Asn Asn Gly Gly Trp Cys 
            20                  25                  30          


Gly Gly Ala Gly Trp Ser Asn Asn Ser Asn Asn Ser Asn Asn Gly Cys 
        35                  40                  45              


Ala Gly Gly Cys Cys Gly Cys Gly Cys Cys Gly Cys Cys Cys Gly Cys 
    50                  55                  60                  


Cys 
65  


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Dha or Dhb

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is Dha or Dhb

<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  X is any amino acid

<400>  107

Ala Ala Cys Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Cys 
1               5                   10              


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  108

Ala Ala Cys Lys Gly Pro Ser Pro Thr Pro Asn Asn Cys 
1               5                   10              


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  109

Ala Ala Cys Ser Arg Ser Ser Pro Ser Arg Thr Tyr Cys 
1               5                   10              


<210>  110
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  110

Ala Ala Cys Thr Asn Ser Ser Pro Thr Gln Val Thr Cys 
1               5                   10              


<210>  111
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  111

Ala Ala Cys Asn Asp Ala Ser Pro Ser Pro Asn Met Cys 
1               5                   10              


<210>  112
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  112

Ala Ala Cys Lys Leu Arg Thr Pro Ser Asn Gln Gln Cys 
1               5                   10              


<210>  113
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  113

Ala Ala Cys His Ile Gly Ser Pro Ser Ile Asn Gln Cys 
1               5                   10              


<210>  114
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  114

Ala Ala Cys Gly Pro Thr Thr Pro Thr Ser Pro Pro Cys 
1               5                   10              


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  115

Ala Ala Cys Pro Gly Pro Thr Pro Thr Asn Met Pro Cys 
1               5                   10              


<210>  116
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  116

Ala Ala Cys Met Tyr Leu Thr Pro Thr Arg Ser Leu Cys 
1               5                   10              


<210>  117
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  117

Ala Ala Cys Thr Ile Phe Thr Pro Ser Pro Phe Phe Cys 
1               5                   10              


<210>  118
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  118

Ala Ala Cys Thr Ala Pro Ser Pro Ser Val Thr Gln Cys 
1               5                   10              


<210>  119
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  119

Ala Ala Cys Leu Lys Pro Thr Pro Thr Gln Ser Thr Cys 
1               5                   10              


<210>  120
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  120

Ala Ala Cys Ser Lys Gly Ser Pro Ser Pro Ser His Cys 
1               5                   10              


<210>  121
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  121

Ala Ala Cys Thr Ser His Thr Pro Thr His Lys Asn Cys 
1               5                   10              


<210>  122
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  122

Ala Ala Cys Val Gln Thr Thr Pro Thr Leu Ile Gly Cys 
1               5                   10              


<210>  123
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  123

Ala Ala Cys Pro Val Ser Thr Pro Thr Leu Thr Ser Cys 
1               5                   10              


<210>  124
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  124

Ala Ala Cys Ser Phe Gln Ser Pro Ser Leu Thr His Cys 
1               5                   10              


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  125

Ala Ala Cys Ser Asn Thr Thr Pro Thr Pro Asp Tyr Cys 
1               5                   10              


<210>  126
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  126

Ala Ala Cys Gln Ser Asn Thr Pro Thr Arg Thr Pro Cys 
1               5                   10              


<210>  127
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  127

Ala Ala Cys Leu Ser Thr Ser Pro Ser Lys Ile Pro Cys 
1               5                   10              


<210>  128
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  128

Ala Ala Cys Thr Met Ala Thr Pro Ser Lys Asn Gly Cys 
1               5                   10              


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  129

Ala Ala Cys Gln Pro Asn Ser Pro Ser Lys Lys Ile Cys 
1               5                   10              


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  130

Ala Ala Cys Met Pro Trp Thr Pro Ser Leu Phe Arg Cys 
1               5                   10              


<210>  131
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  131

Ala Ala Cys Thr Phe Leu Ser Pro Ser Thr Pro Ile Cys 
1               5                   10              


<210>  132
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  132

Ala Ala Cys Thr Ser Asn Thr Pro Thr Thr Arg Thr Cys 
1               5                   10              


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  133

Ala Ala Cys Thr Ile Gly Ser Pro Ser Leu Arg His Cys 
1               5                   10              


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  134

Ala Ala Cys Leu Phe Arg Thr Pro Thr Pro Phe Ser Cys 
1               5                   10              


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  135

Ala Ala Cys Lys Asp Met Thr Pro Ser Pro Lys Thr Cys 
1               5                   10              


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  136

Ala Ala Cys Lys Leu Gly Thr Pro Thr Asp Lys Thr Cys 
1               5                   10              


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  137

Ala Ala Cys Met Asp Thr Ser Pro Thr Pro Pro Ser Cys 
1               5                   10              


<210>  138
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  138

Ala Ala Cys Ala Phe Trp Ser Pro Ser Ile Met Ser Cys 
1               5                   10              


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  139

Ala Ala Cys Pro Pro Val Ser Pro Ser Asn Asp Arg Cys 
1               5                   10              


<210>  140
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  140

Ala Ala Cys Thr Met Gly Thr Pro Thr Gln Ser Gly Cys 
1               5                   10              


<210>  141
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  141

Ala Ala Cys Thr Asn Leu Ser Pro Thr Gln Asp Gln Cys 
1               5                   10              


<210>  142
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  142

Ala Ala Cys His Lys Ser Ser Pro Thr Gln Val Tyr Cys 
1               5                   10              


<210>  143
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  143

Ala Ala Cys Phe Ile Arg Thr Pro Ser Phe Gln Arg Cys 
1               5                   10              


<210>  144
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  144

Ala Ala Cys Pro Lys Pro Thr Pro Ser Ala Leu Lys Cys 
1               5                   10              


<210>  145
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  145

Ala Ala Cys Leu Phe Arg Ser Pro Thr Pro Phe Ser Cys 
1               5                   10              


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  146

Ala Ala Cys His Thr Pro Thr Pro Thr Thr Leu Ser Cys 
1               5                   10              


<210>  147
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  147

Ala Ala Cys Ser Ser Arg Thr Pro Thr Thr Thr Glu Cys 
1               5                   10              


<210>  148
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  148

Ala Ala Cys Asn Ser Ser Thr Pro Thr Pro Asp Thr Cys 
1               5                   10              


<210>  149
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  149

Ala Ala Cys Asn Tyr Trp Ser Pro Thr Tyr Glu Asp Cys 
1               5                   10              


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  150

Ala Ala Cys Lys Gly Ala Ser Pro Ser Leu Pro Lys Cys 
1               5                   10              


<210>  151
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  151

Lys Pro Thr Thr Val Lys Pro Pro Ser Asp Phe Glu Glu Trp Thr Ile 
1               5                   10                  15      


Asn Val Cys 
            


<210>  152
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  152

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


<210>  153
<211>  1068
<212>  PRT
<213>  Prochlorococcus marinus

<400>  153

Met Glu Ser Pro Ser Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
1               5                   10                  15      


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
            20                  25                  30          


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu 
        35                  40                  45              


Glu Glu Asp Asp Pro Cys Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu 
    50                  55                  60                  


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Asn 
65                  70                  75                  80  


Leu Asn Arg Pro Phe Val Asp Val Trp Trp Pro Ile Arg Cys His Ser 
                85                  90                  95      


Ala Glu Ser Leu Arg Gln Ser Phe Val Ser Asp Ser Ala Gly Leu Ala 
            100                 105                 110         


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
        115                 120                 125             


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
    130                 135                 140                 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
145                 150                 155                 160 


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
                165                 170                 175     


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
            180                 185                 190         


Leu Ile Gly Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
        195                 200                 205             


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Cys Phe Ala 
    210                 215                 220                 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
225                 230                 235                 240 


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
                245                 250                 255     


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
            260                 265                 270         


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr 
        275                 280                 285             


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asn 
    290                 295                 300                 


Gly Tyr Gly Tyr Met Glu His Val Val His His Leu Cys Ala Asn Asp 
305                 310                 315                 320 


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
                325                 330                 335     


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
            340                 345                 350         


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
        355                 360                 365             


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
    370                 375                 380                 


Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln Arg Ser Val Leu Arg Ser 
385                 390                 395                 400 


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Leu Ala Ile 
                405                 410                 415     


Asp Ile Ser Ala Leu Gly Met Ser Pro Pro Asn Lys Pro Glu Arg Ile 
            420                 425                 430         


Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
        435                 440                 445             


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Gly 
    450                 455                 460                 


Glu Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
465                 470                 475                 480 


Ser Met Gln Ser Glu Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
                485                 490                 495     


Val Asn Gly Val Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
            500                 505                 510         


Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu 
        515                 520                 525             


Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln 
    530                 535                 540                 


Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
545                 550                 555                 560 


Ile Phe Ala Ala Glu Val Lys Gln Met Gln His Leu Asp Ile Pro Phe 
                565                 570                 575     


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
            580                 585                 590         


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
        595                 600                 605             


Glu Arg Leu Arg Asn Leu Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg 
    610                 615                 620                 


Leu Ile Arg Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
625                 630                 635                 640 


Ser Ser Pro Thr Leu Pro Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
                645                 650                 655     


Ser Ser Ala Glu Thr Ser Leu Glu Ala Ala Lys Arg Ile Ala His Arg 
            660                 665                 670         


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
        675                 680                 685             


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ser Phe Gly Pro Val 
    690                 695                 700                 


Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ala His Leu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Gln Gln Val Ser Leu Met Asp Ala Asp Ala Ile Gln 
                725                 730                 735     


Thr Ala Ile Leu Gln Pro Leu Val Gly Leu Val Asp Gln Pro Ser Asp 
            740                 745                 750         


Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly 
        755                 760                 765             


Cys Gly Gly Thr Leu Leu Ala Leu Thr Leu Gln Gly Glu Gln Ala Met 
    770                 775                 780                 


Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp 
785                 790                 795                 800 


Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu 
                805                 810                 815     


Val Gln Leu Gly Thr Glu Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly 
            820                 825                 830         


Asp His Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser 
        835                 840                 845             


Ser Ser Gln Pro Gly Leu Leu Gly Phe Ser His Gly Thr Ala Gly Tyr 
    850                 855                 860                 


Ala Ala Ala Leu Ala His Leu His Ala Phe Ser Ala Asp Glu Arg Tyr 
865                 870                 875                 880 


Arg Thr Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn 
                885                 890                 895     


Lys Asp Ala Gly Asn Trp Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser 
            900                 905                 910         


Asp Ser Asp Glu Pro Ser Phe Met Ala Ser Trp Cys His Gly Ala Pro 
        915                 920                 925             


Gly Ile Ala Leu Gly Arg Ala Cys Leu Trp Gly Thr Ala Leu Trp Asp 
    930                 935                 940                 


Glu Glu Cys Thr Lys Glu Ile Gly Ile Gly Leu Gln Thr Thr Ala Ala 
945                 950                 955                 960 


Val Ser Ser Val Ser Thr Asp His Leu Cys Cys Gly Ser Leu Gly Leu 
                965                 970                 975     


Met Val Leu Leu Glu Met Leu Ser Ala Gly Pro Trp Pro Ile Asp Asn 
            980                 985                 990         


Gln Leu Arg Ser His Cys Gln Asp  Val Ala Phe Gln Tyr  Arg Leu Gln 
        995                 1000                 1005             


Ala Leu  Gln Arg Cys Ser Ala  Glu Pro Ile Lys Leu  Arg Cys Phe 
    1010                 1015                 1020             


Gly Thr  Lys Glu Gly Leu Leu  Val Leu Pro Gly Phe  Phe Thr Gly 
    1025                 1030                 1035             


Leu Ser  Gly Met Gly Leu Ala  Leu Leu Glu Asp Asp  Pro Ser Arg 
    1040                 1045                 1050             


Ala Val  Val Ser Gln Leu Ile  Ser Ala Gly Leu Trp  Pro Thr Glu 
    1055                 1060                 1065             


<210>  154
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  154

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ser Ala Ser Gly Ser Gly Ser Gly Ser Ala Met Glu Ser Pro Ser Ser 
65                  70                  75                  80  


Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala Pro Asp Glu Pro His Lys 
                85                  90                  95      


Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu Ser Glu Glu Asn Phe Phe 
            100                 105                 110         


Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu Glu Glu Asp Asp Pro Cys 
        115                 120                 125             


Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu Ala Leu Lys Ala Ala Trp 
    130                 135                 140                 


Asp Leu Pro Leu Leu Pro Val Asp Asn Asn Leu Asn Arg Pro Phe Val 
145                 150                 155                 160 


Asp Val Trp Trp Pro Ile Arg Cys His Ser Ala Glu Ser Leu Arg Gln 
                165                 170                 175     


Ser Phe Val Ser Asp Ser Ala Gly Leu Ala Asp Glu Ile Phe Asp Gln 
            180                 185                 190         


Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys Ala Leu Gly Asp Gln Val 
        195                 200                 205             


Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr Pro Gly Thr Met Leu Leu 
    210                 215                 220                 


Ala His Leu Gly Ala Ala Gly Asp Gly Ser Gly Pro Pro Val Arg Glu 
225                 230                 235                 240 


His Tyr Glu Arg Phe Ile Gln Ser His Arg Arg Asn Gly Leu Ala Pro 
                245                 250                 255     


Leu Leu Lys Glu Phe Pro Val Leu Gly Arg Leu Ile Gly Thr Val Leu 
            260                 265                 270         


Ser Leu Trp Phe Gln Gly Ser Val Glu Met Leu Gln Arg Ile Cys Ala 
        275                 280                 285             


Asp Arg Thr Val Leu Gln Gln Cys Phe Ala Ile Pro Cys Gly His His 
    290                 295                 300                 


Leu Lys Thr Val Lys Gln Gly Leu Ser Asp Pro His Arg Gly Gly Arg 
305                 310                 315                 320 


Ala Val Ala Val Leu Glu Phe Ala Asp Pro Asn Ser Thr Ala Asn Ser 
                325                 330                 335     


Ser Met His Val Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala Ala 
            340                 345                 350         


Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr His Ser Asp Leu Ser Pro 
        355                 360                 365             


Leu Arg Thr Leu Ala Ile His Asn Gly Asn Gly Tyr Gly Tyr Met Glu 
    370                 375                 380                 


His Val Val His His Leu Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe 
385                 390                 395                 400 


Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys 
                405                 410                 415     


Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu 
            420                 425                 430         


Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile 
        435                 440                 445             


Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln 
    450                 455                 460                 


Lys Gln Phe Gln Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp 
465                 470                 475                 480 


Met Phe Leu Gly Glu Ser Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly 
                485                 490                 495     


Met Ser Pro Pro Asn Lys Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly 
            500                 505                 510         


Phe Asn Ser Asp Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu 
        515                 520                 525             


Ile Pro Thr Ser Leu Pro Val Gly Ile Gly Glu Val Asn Pro Phe Asp 
    530                 535                 540                 


Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Glu Ala 
545                 550                 555                 560 


Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp Val Asn Gly Val Leu Ala 
                565                 570                 575     


His Phe Ala Gly Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val 
            580                 585                 590         


Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser 
        595                 600                 605             


Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu 
    610                 615                 620                 


Leu Ala Glu Ser Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu Val 
625                 630                 635                 640 


Lys Gln Met Gln His Leu Asp Ile Pro Phe Phe Thr His Leu Ile Asp 
                645                 650                 655     


Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu Gln Glu Leu Pro Gly Phe 
            660                 665                 670         


Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr Glu Arg Leu Arg Asn Leu 
        675                 680                 685             


Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg Leu Ile Arg Gly Ala Val 
    690                 695                 700                 


Glu Ala Arg Glu Leu His Thr Thr Pro Glu Ser Ser Pro Thr Leu Pro 
705                 710                 715                 720 


Pro Pro Ala Thr Pro Glu Ala Leu Met Ser Ser Ser Ala Glu Thr Ser 
                725                 730                 735     


Leu Glu Ala Ala Lys Arg Ile Ala His Arg Leu Leu Glu Leu Ala Ile 
            740                 745                 750         


Arg Asp Ser Gln Gly Gln Val Glu Trp Leu Gly Met Asp Leu Gly Ala 
        755                 760                 765             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Leu Ser Leu Tyr Gly 
    770                 775                 780                 


Gly Ser Ile Gly Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln 
785                 790                 795                 800 


Val Ser Leu Met Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro 
                805                 810                 815     


Leu Val Gly Leu Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp 
            820                 825                 830         


Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu 
        835                 840                 845             


Ala Leu Thr Leu Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile 
865                 870                 875                 880 


Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu 
                885                 890                 895     


Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln 
            900                 905                 910         


Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu 
        915                 920                 925             


Leu Gly Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His 
    930                 935                 940                 


Leu His Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala 
945                 950                 955                 960 


Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp 
                965                 970                 975     


Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser Asp Ser Asp Glu Pro Ser 
            980                 985                 990         


Phe Met Ala Ser Trp Cys His Gly  Ala Pro Gly Ile Ala  Leu Gly Arg 
        995                 1000                 1005             


Ala Cys  Leu Trp Gly Thr Ala  Leu Trp Asp Glu Glu  Cys Thr Lys 
    1010                 1015                 1020             


Glu Ile  Gly Ile Gly Leu Gln  Thr Thr Ala Ala Val  Ser Ser Val 
    1025                 1030                 1035             


Ser Thr  Asp His Leu Cys Cys  Gly Ser Leu Gly Leu  Met Val Leu 
    1040                 1045                 1050             


Leu Glu  Met Leu Ser Ala Gly  Pro Trp Pro Ile Asp  Asn Gln Leu 
    1055                 1060                 1065             


Arg Ser  His Cys Gln Asp Val  Ala Phe Gln Tyr Arg  Leu Gln Ala 
    1070                 1075                 1080             


Leu Gln  Arg Cys Ser Ala Glu  Pro Ile Lys Leu Arg  Cys Phe Gly 
    1085                 1090                 1095             


Thr Lys  Glu Gly Leu Leu Val  Leu Pro Gly Phe Phe  Thr Gly Leu 
    1100                 1105                 1110             


Ser Gly  Met Gly Leu Ala Leu  Leu Glu Asp Asp Pro  Ser Arg Ala 
    1115                 1120                 1125             


Val Val  Ser Gln Leu Ile Ser  Ala Gly Leu Trp Pro  Thr Glu 
    1130                 1135                 1140         


<210>  155
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  155

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Ala Met Glu Ser Pro Ser Ser Trp Lys Thr Ser 
                85                  90                  95      


Trp Leu Ala Ala Ile Ala Pro Asp Glu Pro His Lys Phe Asp Arg Arg 
            100                 105                 110         


Leu Glu Trp Asp Glu Leu Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn 
        115                 120                 125             


Ser Glu Pro Ala Ser Leu Glu Glu Asp Asp Pro Cys Phe Glu Glu Ala 
    130                 135                 140                 


Leu Gln Asp Ala Leu Glu Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu 
145                 150                 155                 160 


Leu Pro Val Asp Asn Asn Leu Asn Arg Pro Phe Val Asp Val Trp Trp 
                165                 170                 175     


Pro Ile Arg Cys His Ser Ala Glu Ser Leu Arg Gln Ser Phe Val Ser 
            180                 185                 190         


Asp Ser Ala Gly Leu Ala Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser 
        195                 200                 205             


Leu Leu Asp Arg Leu Cys Ala Leu Gly Asp Gln Val Leu Trp Glu Ala 
    210                 215                 220                 


Phe Asn Lys Glu Arg Thr Pro Gly Thr Met Leu Leu Ala His Leu Gly 
225                 230                 235                 240 


Ala Ala Gly Asp Gly Ser Gly Pro Pro Val Arg Glu His Tyr Glu Arg 
                245                 250                 255     


Phe Ile Gln Ser His Arg Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu 
            260                 265                 270         


Phe Pro Val Leu Gly Arg Leu Ile Gly Thr Val Leu Ser Leu Trp Phe 
        275                 280                 285             


Gln Gly Ser Val Glu Met Leu Gln Arg Ile Cys Ala Asp Arg Thr Val 
    290                 295                 300                 


Leu Gln Gln Cys Phe Ala Ile Pro Cys Gly His His Leu Lys Thr Val 
305                 310                 315                 320 


Lys Gln Gly Leu Ser Asp Pro His Arg Gly Gly Arg Ala Val Ala Val 
                325                 330                 335     


Leu Glu Phe Ala Asp Pro Asn Ser Thr Ala Asn Ser Ser Met His Val 
            340                 345                 350         


Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala Ala Tyr Gln Ala Thr 
        355                 360                 365             


Leu Ala Asp Leu Asn Thr His Ser Asp Leu Ser Pro Leu Arg Thr Leu 
    370                 375                 380                 


Ala Ile His Asn Gly Asn Gly Tyr Gly Tyr Met Glu His Val Val His 
385                 390                 395                 400 


His Leu Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala 
                405                 410                 415     


Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys Thr Asp Cys His 
            420                 425                 430         


His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr 
        435                 440                 445             


Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile Ser Asp Ala Ser 
    450                 455                 460                 


Ser Thr Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln 
465                 470                 475                 480 


Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp Met Phe Leu Gly 
                485                 490                 495     


Glu Ser Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly Met Ser Pro Pro 
            500                 505                 510         


Asn Lys Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp 
        515                 520                 525             


Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu Ile Pro Thr Ser 
    530                 535                 540                 


Leu Pro Val Gly Ile Gly Glu Val Asn Pro Phe Asp Arg Phe Leu Glu 
545                 550                 555                 560 


Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Glu Ala Leu Ile Lys Leu 
                565                 570                 575     


Arg Asn Arg Trp Leu Asp Val Asn Gly Val Leu Ala His Phe Ala Gly 
            580                 585                 590         


Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile 
        595                 600                 605             


Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln 
    610                 615                 620                 


Ala Leu Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser 
625                 630                 635                 640 


Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu Val Lys Gln Met Gln 
                645                 650                 655     


His Leu Asp Ile Pro Phe Phe Thr His Leu Ile Asp Ala Asp Ala Leu 
            660                 665                 670         


Gln Leu Gly Gly Leu Glu Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser 
        675                 680                 685             


Gly Leu Ala Ala Ala Tyr Glu Arg Leu Arg Asn Leu Asp Thr Asp Glu 
    690                 695                 700                 


Ile Ala Phe Gln Leu Arg Leu Ile Arg Gly Ala Val Glu Ala Arg Glu 
705                 710                 715                 720 


Leu His Thr Thr Pro Glu Ser Ser Pro Thr Leu Pro Pro Pro Ala Thr 
                725                 730                 735     


Pro Glu Ala Leu Met Ser Ser Ser Ala Glu Thr Ser Leu Glu Ala Ala 
            740                 745                 750         


Lys Arg Ile Ala His Arg Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln 
        755                 760                 765             


Gly Gln Val Glu Trp Leu Gly Met Asp Leu Gly Ala Asp Gly Glu Ser 
    770                 775                 780                 


Phe Ser Phe Gly Pro Val Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly 
785                 790                 795                 800 


Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln Val Ser Leu Met 
                805                 810                 815     


Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro Leu Val Gly Leu 
            820                 825                 830         


Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln 
        835                 840                 845             


Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu Ala Leu Thr Leu 
    850                 855                 860                 


Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro 
865                 870                 875                 880 


Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala 
                885                 890                 895     


Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu Ser Ala Leu Gln 
            900                 905                 910         


Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln Gln Asn Glu Glu 
        915                 920                 925             


Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu Leu Gly Phe Ser 
    930                 935                 940                 


His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His Leu His Ala Phe 
945                 950                 955                 960 


Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala Ala Leu Ala Tyr 
                965                 970                 975     


Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp Pro Asp Tyr Arg 
            980                 985                 990         


Ser Ile Gly Arg Asp Ser Asp Ser  Asp Glu Pro Ser Phe  Met Ala Ser 
        995                 1000                 1005             


Trp Cys  His Gly Ala Pro Gly  Ile Ala Leu Gly Arg  Ala Cys Leu 
    1010                 1015                 1020             


Trp Gly  Thr Ala Leu Trp Asp  Glu Glu Cys Thr Lys  Glu Ile Gly 
    1025                 1030                 1035             


Ile Gly  Leu Gln Thr Thr Ala  Ala Val Ser Ser Val  Ser Thr Asp 
    1040                 1045                 1050             


His Leu  Cys Cys Gly Ser Leu  Gly Leu Met Val Leu  Leu Glu Met 
    1055                 1060                 1065             


Leu Ser  Ala Gly Pro Trp Pro  Ile Asp Asn Gln Leu  Arg Ser His 
    1070                 1075                 1080             


Cys Gln  Asp Val Ala Phe Gln  Tyr Arg Leu Gln Ala  Leu Gln Arg 
    1085                 1090                 1095             


Cys Ser  Ala Glu Pro Ile Lys  Leu Arg Cys Phe Gly  Thr Lys Glu 
    1100                 1105                 1110             


Gly Leu  Leu Val Leu Pro Gly  Phe Phe Thr Gly Leu  Ser Gly Met 
    1115                 1120                 1125             


Gly Leu  Ala Leu Leu Glu Asp  Asp Pro Ser Arg Ala  Val Val Ser 
    1130                 1135                 1140             


Gln Leu  Ile Ser Ala Gly Leu  Trp Pro Thr Glu 
    1145                 1150                 


<210>  156
<211>  1164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  156

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ala 
                85                  90                  95      


Met Glu Ser Pro Ser Ser Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala 
            100                 105                 110         


Pro Asp Glu Pro His Lys Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu 
        115                 120                 125             


Ser Glu Glu Asn Phe Phe Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu 
    130                 135                 140                 


Glu Glu Asp Asp Pro Cys Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu 
145                 150                 155                 160 


Ala Leu Lys Ala Ala Trp Asp Leu Pro Leu Leu Pro Val Asp Asn Asn 
                165                 170                 175     


Leu Asn Arg Pro Phe Val Asp Val Trp Trp Pro Ile Arg Cys His Ser 
            180                 185                 190         


Ala Glu Ser Leu Arg Gln Ser Phe Val Ser Asp Ser Ala Gly Leu Ala 
        195                 200                 205             


Asp Glu Ile Phe Asp Gln Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys 
    210                 215                 220                 


Ala Leu Gly Asp Gln Val Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr 
225                 230                 235                 240 


Pro Gly Thr Met Leu Leu Ala His Leu Gly Ala Ala Gly Asp Gly Ser 
                245                 250                 255     


Gly Pro Pro Val Arg Glu His Tyr Glu Arg Phe Ile Gln Ser His Arg 
            260                 265                 270         


Arg Asn Gly Leu Ala Pro Leu Leu Lys Glu Phe Pro Val Leu Gly Arg 
        275                 280                 285             


Leu Ile Gly Thr Val Leu Ser Leu Trp Phe Gln Gly Ser Val Glu Met 
    290                 295                 300                 


Leu Gln Arg Ile Cys Ala Asp Arg Thr Val Leu Gln Gln Cys Phe Ala 
305                 310                 315                 320 


Ile Pro Cys Gly His His Leu Lys Thr Val Lys Gln Gly Leu Ser Asp 
                325                 330                 335     


Pro His Arg Gly Gly Arg Ala Val Ala Val Leu Glu Phe Ala Asp Pro 
            340                 345                 350         


Asn Ser Thr Ala Asn Ser Ser Met His Val Val Tyr Lys Pro Lys Asp 
        355                 360                 365             


Met Ala Val Asp Ala Ala Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr 
    370                 375                 380                 


His Ser Asp Leu Ser Pro Leu Arg Thr Leu Ala Ile His Asn Gly Asn 
385                 390                 395                 400 


Gly Tyr Gly Tyr Met Glu His Val Val His His Leu Cys Ala Asn Asp 
                405                 410                 415     


Lys Glu Leu Thr Asn Phe Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu 
            420                 425                 430         


Leu His Leu Leu Gly Cys Thr Asp Cys His His Glu Asn Leu Ile Ala 
        435                 440                 445             


Cys Gly Asp Gln Leu Leu Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala 
    450                 455                 460                 


Asp Leu Pro Asp His Ile Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro 
465                 470                 475                 480 


Lys Pro Ser Ser Leu Gln Lys Gln Phe Gln Arg Ser Val Leu Arg Ser 
                485                 490                 495     


Gly Leu Leu Pro Gln Trp Met Phe Leu Gly Glu Ser Lys Leu Ala Ile 
            500                 505                 510         


Asp Ile Ser Ala Leu Gly Met Ser Pro Pro Asn Lys Pro Glu Arg Ile 
        515                 520                 525             


Ala Leu Gly Trp Leu Gly Phe Asn Ser Asp Gly Met Met Pro Gly Arg 
    530                 535                 540                 


Val Ser Gln Pro Val Glu Ile Pro Thr Ser Leu Pro Val Gly Ile Gly 
545                 550                 555                 560 


Glu Val Asn Pro Phe Asp Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe 
                565                 570                 575     


Ser Met Gln Ser Glu Ala Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp 
            580                 585                 590         


Val Asn Gly Val Leu Ala His Phe Ala Gly Leu Pro Arg Arg Ile Val 
        595                 600                 605             


Leu Arg Ala Thr Arg Val Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu 
    610                 615                 620                 


Pro Thr Ala Leu Arg Ser Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln 
625                 630                 635                 640 


Leu Thr Arg Ser Phe Leu Leu Ala Glu Ser Lys Pro Leu His Trp Pro 
                645                 650                 655     


Ile Phe Ala Ala Glu Val Lys Gln Met Gln His Leu Asp Ile Pro Phe 
            660                 665                 670         


Phe Thr His Leu Ile Asp Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu 
        675                 680                 685             


Gln Glu Leu Pro Gly Phe Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr 
    690                 695                 700                 


Glu Arg Leu Arg Asn Leu Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg 
705                 710                 715                 720 


Leu Ile Arg Gly Ala Val Glu Ala Arg Glu Leu His Thr Thr Pro Glu 
                725                 730                 735     


Ser Ser Pro Thr Leu Pro Pro Pro Ala Thr Pro Glu Ala Leu Met Ser 
            740                 745                 750         


Ser Ser Ala Glu Thr Ser Leu Glu Ala Ala Lys Arg Ile Ala His Arg 
        755                 760                 765             


Leu Leu Glu Leu Ala Ile Arg Asp Ser Gln Gly Gln Val Glu Trp Leu 
    770                 775                 780                 


Gly Met Asp Leu Gly Ala Asp Gly Glu Ser Phe Ser Phe Gly Pro Val 
785                 790                 795                 800 


Gly Leu Ser Leu Tyr Gly Gly Ser Ile Gly Ile Ala His Leu Leu Gln 
                805                 810                 815     


Arg Leu Gln Ala Gln Gln Val Ser Leu Met Asp Ala Asp Ala Ile Gln 
            820                 825                 830         


Thr Ala Ile Leu Gln Pro Leu Val Gly Leu Val Asp Gln Pro Ser Asp 
        835                 840                 845             


Asp Gly Arg Arg Arg Trp Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly 
    850                 855                 860                 


Cys Gly Gly Thr Leu Leu Ala Leu Thr Leu Gln Gly Glu Gln Ala Met 
865                 870                 875                 880 


Ala Asn Ser Leu Leu Ala Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp 
                885                 890                 895     


Gln Gln Leu Asp Leu Ile Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu 
            900                 905                 910         


Val Gln Leu Gly Thr Glu Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly 
        915                 920                 925             


Asp His Leu Ile Ala Gln Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser 
    930                 935                 940                 


Ser Ser Gln Pro Gly Leu Leu Gly Phe Ser His Gly Thr Ala Gly Tyr 
945                 950                 955                 960 


Ala Ala Ala Leu Ala His Leu His Ala Phe Ser Ala Asp Glu Arg Tyr 
                965                 970                 975     


Arg Thr Ala Ala Ala Ala Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn 
            980                 985                 990         


Lys Asp Ala Gly Asn Trp Pro Asp  Tyr Arg Ser Ile Gly  Arg Asp Ser 
        995                 1000                 1005             


Asp Ser  Asp Glu Pro Ser Phe  Met Ala Ser Trp Cys  His Gly Ala 
    1010                 1015                 1020             


Pro Gly  Ile Ala Leu Gly Arg  Ala Cys Leu Trp Gly  Thr Ala Leu 
    1025                 1030                 1035             


Trp Asp  Glu Glu Cys Thr Lys  Glu Ile Gly Ile Gly  Leu Gln Thr 
    1040                 1045                 1050             


Thr Ala  Ala Val Ser Ser Val  Ser Thr Asp His Leu  Cys Cys Gly 
    1055                 1060                 1065             


Ser Leu  Gly Leu Met Val Leu  Leu Glu Met Leu Ser  Ala Gly Pro 
    1070                 1075                 1080             


Trp Pro  Ile Asp Asn Gln Leu  Arg Ser His Cys Gln  Asp Val Ala 
    1085                 1090                 1095             


Phe Gln  Tyr Arg Leu Gln Ala  Leu Gln Arg Cys Ser  Ala Glu Pro 
    1100                 1105                 1110             


Ile Lys  Leu Arg Cys Phe Gly  Thr Lys Glu Gly Leu  Leu Val Leu 
    1115                 1120                 1125             


Pro Gly  Phe Phe Thr Gly Leu  Ser Gly Met Gly Leu  Ala Leu Leu 
    1130                 1135                 1140             


Glu Asp  Asp Pro Ser Arg Ala  Val Val Ser Gln Leu  Ile Ser Ala 
    1145                 1150                 1155             


Gly Leu  Trp Pro Thr Glu 
    1160                 


<210>  157
<211>  1216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  157

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ser Ala Ser Gly Ser Gly Ser Gly Ser Ala Met Glu Ser Pro Ser Ser 
65                  70                  75                  80  


Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala Pro Asp Glu Pro His Lys 
                85                  90                  95      


Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu Ser Glu Glu Asn Phe Phe 
            100                 105                 110         


Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu Glu Glu Asp Asp Pro Cys 
        115                 120                 125             


Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu Ala Leu Lys Ala Ala Trp 
    130                 135                 140                 


Asp Leu Pro Leu Leu Pro Val Asp Asn Asn Leu Asn Arg Pro Phe Val 
145                 150                 155                 160 


Asp Val Trp Trp Pro Ile Arg Cys His Ser Ala Glu Ser Leu Arg Gln 
                165                 170                 175     


Ser Phe Val Ser Asp Ser Ala Gly Leu Ala Asp Glu Ile Phe Asp Gln 
            180                 185                 190         


Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys Ala Leu Gly Asp Gln Val 
        195                 200                 205             


Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr Pro Gly Thr Met Leu Leu 
    210                 215                 220                 


Ala His Leu Gly Ala Ala Gly Asp Gly Ser Gly Pro Pro Val Arg Glu 
225                 230                 235                 240 


His Tyr Glu Arg Phe Ile Gln Ser His Arg Arg Asn Gly Leu Ala Pro 
                245                 250                 255     


Leu Leu Lys Glu Phe Pro Val Leu Gly Arg Leu Ile Gly Thr Val Leu 
            260                 265                 270         


Ser Leu Trp Phe Gln Gly Ser Val Glu Met Leu Gln Arg Ile Cys Ala 
        275                 280                 285             


Asp Arg Thr Val Leu Gln Gln Cys Phe Ala Ile Pro Cys Gly His His 
    290                 295                 300                 


Leu Lys Thr Val Lys Gln Gly Leu Ser Asp Pro His Arg Gly Gly Arg 
305                 310                 315                 320 


Ala Val Ala Val Leu Glu Phe Ala Asp Pro Asn Ser Thr Ala Asn Ser 
                325                 330                 335     


Ser Met His Val Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala Ala 
            340                 345                 350         


Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr His Ser Asp Leu Ser Pro 
        355                 360                 365             


Leu Arg Thr Leu Ala Ile His Asn Gly Asn Gly Tyr Gly Tyr Met Glu 
    370                 375                 380                 


His Val Val His His Leu Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe 
385                 390                 395                 400 


Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys 
                405                 410                 415     


Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu 
            420                 425                 430         


Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile 
        435                 440                 445             


Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln 
    450                 455                 460                 


Lys Gln Phe Gln Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp 
465                 470                 475                 480 


Met Phe Leu Gly Glu Ser Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly 
                485                 490                 495     


Met Ser Pro Pro Asn Lys Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly 
            500                 505                 510         


Phe Asn Ser Asp Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu 
        515                 520                 525             


Ile Pro Thr Ser Leu Pro Val Gly Ile Gly Glu Val Asn Pro Phe Asp 
    530                 535                 540                 


Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Glu Ala 
545                 550                 555                 560 


Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp Val Asn Gly Val Leu Ala 
                565                 570                 575     


His Phe Ala Gly Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val 
            580                 585                 590         


Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser 
        595                 600                 605             


Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu 
    610                 615                 620                 


Leu Ala Glu Ser Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu Val 
625                 630                 635                 640 


Lys Gln Met Gln His Leu Asp Ile Pro Phe Phe Thr His Leu Ile Asp 
                645                 650                 655     


Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu Gln Glu Leu Pro Gly Phe 
            660                 665                 670         


Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr Glu Arg Leu Arg Asn Leu 
        675                 680                 685             


Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg Leu Ile Arg Gly Ala Val 
    690                 695                 700                 


Glu Ala Arg Glu Leu His Thr Thr Pro Glu Ser Ser Pro Thr Leu Pro 
705                 710                 715                 720 


Pro Pro Ala Thr Pro Glu Ala Leu Met Ser Ser Ser Ala Glu Thr Ser 
                725                 730                 735     


Leu Glu Ala Ala Lys Arg Ile Ala His Arg Leu Leu Glu Leu Ala Ile 
            740                 745                 750         


Arg Asp Ser Gln Gly Gln Val Glu Trp Leu Gly Met Asp Leu Gly Ala 
        755                 760                 765             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Leu Ser Leu Tyr Gly 
    770                 775                 780                 


Gly Ser Ile Gly Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln 
785                 790                 795                 800 


Val Ser Leu Met Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro 
                805                 810                 815     


Leu Val Gly Leu Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp 
            820                 825                 830         


Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu 
        835                 840                 845             


Ala Leu Thr Leu Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile 
865                 870                 875                 880 


Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu 
                885                 890                 895     


Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln 
            900                 905                 910         


Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu 
        915                 920                 925             


Leu Gly Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His 
    930                 935                 940                 


Leu His Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala 
945                 950                 955                 960 


Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp 
                965                 970                 975     


Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser Asp Ser Asp Glu Pro Ser 
            980                 985                 990         


Phe Met Ala Ser Trp Cys His Gly  Ala Pro Gly Ile Ala  Leu Gly Arg 
        995                 1000                 1005             


Ala Cys  Leu Trp Gly Thr Ala  Leu Trp Asp Glu Glu  Cys Thr Lys 
    1010                 1015                 1020             


Glu Ile  Gly Ile Gly Leu Gln  Thr Thr Ala Ala Val  Ser Ser Val 
    1025                 1030                 1035             


Ser Thr  Asp His Leu Cys Cys  Gly Ser Leu Gly Leu  Met Val Leu 
    1040                 1045                 1050             


Leu Glu  Met Leu Ser Ala Gly  Pro Trp Pro Ile Asp  Asn Gln Leu 
    1055                 1060                 1065             


Arg Ser  His Cys Gln Asp Val  Ala Phe Gln Tyr Arg  Leu Gln Ala 
    1070                 1075                 1080             


Leu Gln  Arg Cys Ser Ala Glu  Pro Ile Lys Leu Arg  Cys Phe Gly 
    1085                 1090                 1095             


Thr Lys  Glu Gly Leu Leu Val  Leu Pro Gly Phe Phe  Thr Gly Leu 
    1100                 1105                 1110             


Ser Gly  Met Gly Leu Ala Leu  Leu Glu Asp Asp Pro  Ser Arg Ala 
    1115                 1120                 1125             


Val Val  Ser Gln Leu Ile Ser  Ala Gly Leu Trp Pro  Thr Glu Ser 
    1130                 1135                 1140             


Ala Ser  Gly Ser Gly Ser Gly  Ser Ala Met Ser Glu  Glu Gln Leu 
    1145                 1150                 1155             


Lys Ala  Phe Ile Ala Lys Val  Gln Ala Asp Thr Ser  Leu Gln Glu 
    1160                 1165                 1170             


Gln Leu  Lys Ala Glu Gly Ala  Asp Val Val Ala Ile  Ala Lys Ala 
    1175                 1180                 1185             


Ala Gly  Phe Thr Ile Thr Thr  Glu Asp Leu Asn Ser  His Arg Gln 
    1190                 1195                 1200             


Asn Leu  Thr Asp Asp Glu Leu  Glu Gly Val Ala Gly  Gly 
    1205                 1210                 1215     


<210>  158
<211>  1226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  158

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ser Ala Ser Gly Ser Gly Ser Gly Ser Ala Met Glu Ser Pro Ser Ser 
65                  70                  75                  80  


Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala Pro Asp Glu Pro His Lys 
                85                  90                  95      


Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu Ser Glu Glu Asn Phe Phe 
            100                 105                 110         


Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu Glu Glu Asp Asp Pro Cys 
        115                 120                 125             


Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu Ala Leu Lys Ala Ala Trp 
    130                 135                 140                 


Asp Leu Pro Leu Leu Pro Val Asp Asn Asn Leu Asn Arg Pro Phe Val 
145                 150                 155                 160 


Asp Val Trp Trp Pro Ile Arg Cys His Ser Ala Glu Ser Leu Arg Gln 
                165                 170                 175     


Ser Phe Val Ser Asp Ser Ala Gly Leu Ala Asp Glu Ile Phe Asp Gln 
            180                 185                 190         


Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys Ala Leu Gly Asp Gln Val 
        195                 200                 205             


Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr Pro Gly Thr Met Leu Leu 
    210                 215                 220                 


Ala His Leu Gly Ala Ala Gly Asp Gly Ser Gly Pro Pro Val Arg Glu 
225                 230                 235                 240 


His Tyr Glu Arg Phe Ile Gln Ser His Arg Arg Asn Gly Leu Ala Pro 
                245                 250                 255     


Leu Leu Lys Glu Phe Pro Val Leu Gly Arg Leu Ile Gly Thr Val Leu 
            260                 265                 270         


Ser Leu Trp Phe Gln Gly Ser Val Glu Met Leu Gln Arg Ile Cys Ala 
        275                 280                 285             


Asp Arg Thr Val Leu Gln Gln Cys Phe Ala Ile Pro Cys Gly His His 
    290                 295                 300                 


Leu Lys Thr Val Lys Gln Gly Leu Ser Asp Pro His Arg Gly Gly Arg 
305                 310                 315                 320 


Ala Val Ala Val Leu Glu Phe Ala Asp Pro Asn Ser Thr Ala Asn Ser 
                325                 330                 335     


Ser Met His Val Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala Ala 
            340                 345                 350         


Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr His Ser Asp Leu Ser Pro 
        355                 360                 365             


Leu Arg Thr Leu Ala Ile His Asn Gly Asn Gly Tyr Gly Tyr Met Glu 
    370                 375                 380                 


His Val Val His His Leu Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe 
385                 390                 395                 400 


Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys 
                405                 410                 415     


Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu 
            420                 425                 430         


Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile 
        435                 440                 445             


Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln 
    450                 455                 460                 


Lys Gln Phe Gln Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp 
465                 470                 475                 480 


Met Phe Leu Gly Glu Ser Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly 
                485                 490                 495     


Met Ser Pro Pro Asn Lys Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly 
            500                 505                 510         


Phe Asn Ser Asp Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu 
        515                 520                 525             


Ile Pro Thr Ser Leu Pro Val Gly Ile Gly Glu Val Asn Pro Phe Asp 
    530                 535                 540                 


Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Glu Ala 
545                 550                 555                 560 


Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp Val Asn Gly Val Leu Ala 
                565                 570                 575     


His Phe Ala Gly Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val 
            580                 585                 590         


Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser 
        595                 600                 605             


Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu 
    610                 615                 620                 


Leu Ala Glu Ser Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu Val 
625                 630                 635                 640 


Lys Gln Met Gln His Leu Asp Ile Pro Phe Phe Thr His Leu Ile Asp 
                645                 650                 655     


Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu Gln Glu Leu Pro Gly Phe 
            660                 665                 670         


Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr Glu Arg Leu Arg Asn Leu 
        675                 680                 685             


Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg Leu Ile Arg Gly Ala Val 
    690                 695                 700                 


Glu Ala Arg Glu Leu His Thr Thr Pro Glu Ser Ser Pro Thr Leu Pro 
705                 710                 715                 720 


Pro Pro Ala Thr Pro Glu Ala Leu Met Ser Ser Ser Ala Glu Thr Ser 
                725                 730                 735     


Leu Glu Ala Ala Lys Arg Ile Ala His Arg Leu Leu Glu Leu Ala Ile 
            740                 745                 750         


Arg Asp Ser Gln Gly Gln Val Glu Trp Leu Gly Met Asp Leu Gly Ala 
        755                 760                 765             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Leu Ser Leu Tyr Gly 
    770                 775                 780                 


Gly Ser Ile Gly Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln 
785                 790                 795                 800 


Val Ser Leu Met Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro 
                805                 810                 815     


Leu Val Gly Leu Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp 
            820                 825                 830         


Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu 
        835                 840                 845             


Ala Leu Thr Leu Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile 
865                 870                 875                 880 


Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu 
                885                 890                 895     


Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln 
            900                 905                 910         


Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu 
        915                 920                 925             


Leu Gly Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His 
    930                 935                 940                 


Leu His Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala 
945                 950                 955                 960 


Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp 
                965                 970                 975     


Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser Asp Ser Asp Glu Pro Ser 
            980                 985                 990         


Phe Met Ala Ser Trp Cys His Gly  Ala Pro Gly Ile Ala  Leu Gly Arg 
        995                 1000                 1005             


Ala Cys  Leu Trp Gly Thr Ala  Leu Trp Asp Glu Glu  Cys Thr Lys 
    1010                 1015                 1020             


Glu Ile  Gly Ile Gly Leu Gln  Thr Thr Ala Ala Val  Ser Ser Val 
    1025                 1030                 1035             


Ser Thr  Asp His Leu Cys Cys  Gly Ser Leu Gly Leu  Met Val Leu 
    1040                 1045                 1050             


Leu Glu  Met Leu Ser Ala Gly  Pro Trp Pro Ile Asp  Asn Gln Leu 
    1055                 1060                 1065             


Arg Ser  His Cys Gln Asp Val  Ala Phe Gln Tyr Arg  Leu Gln Ala 
    1070                 1075                 1080             


Leu Gln  Arg Cys Ser Ala Glu  Pro Ile Lys Leu Arg  Cys Phe Gly 
    1085                 1090                 1095             


Thr Lys  Glu Gly Leu Leu Val  Leu Pro Gly Phe Phe  Thr Gly Leu 
    1100                 1105                 1110             


Ser Gly  Met Gly Leu Ala Leu  Leu Glu Asp Asp Pro  Ser Arg Ala 
    1115                 1120                 1125             


Val Val  Ser Gln Leu Ile Ser  Ala Gly Leu Trp Pro  Thr Glu Ser 
    1130                 1135                 1140             


Ala Ser  Gly Ser Gly Ser Gly  Ser Gly Ser Thr Ser  Gly Ser Gly 
    1145                 1150                 1155             


Ser Gly  Ser Ala Met Ser Glu  Glu Gln Leu Lys Ala  Phe Ile Ala 
    1160                 1165                 1170             


Lys Val  Gln Ala Asp Thr Ser  Leu Gln Glu Gln Leu  Lys Ala Glu 
    1175                 1180                 1185             


Gly Ala  Asp Val Val Ala Ile  Ala Lys Ala Ala Gly  Phe Thr Ile 
    1190                 1195                 1200             


Thr Thr  Glu Asp Leu Asn Ser  His Arg Gln Asn Leu  Thr Asp Asp 
    1205                 1210                 1215             


Glu Leu  Glu Gly Val Ala Gly  Gly 
    1220                 1225     


<210>  159
<211>  1236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  159

Met Ser Glu Glu Gln Leu Lys Ala Phe Ile Ala Lys Val Gln Ala Asp 
1               5                   10                  15      


Thr Ser Leu Gln Glu Gln Leu Lys Ala Glu Gly Ala Asp Val Val Ala 
            20                  25                  30          


Ile Ala Lys Ala Ala Gly Phe Thr Ile Thr Thr Glu Asp Leu Asn Ser 
        35                  40                  45              


His Arg Gln Asn Leu Thr Asp Asp Glu Leu Glu Gly Val Ala Gly Gly 
    50                  55                  60                  


Ser Ala Ser Gly Ser Gly Ser Gly Ser Ala Met Glu Ser Pro Ser Ser 
65                  70                  75                  80  


Trp Lys Thr Ser Trp Leu Ala Ala Ile Ala Pro Asp Glu Pro His Lys 
                85                  90                  95      


Phe Asp Arg Arg Leu Glu Trp Asp Glu Leu Ser Glu Glu Asn Phe Phe 
            100                 105                 110         


Ala Ala Leu Asn Ser Glu Pro Ala Ser Leu Glu Glu Asp Asp Pro Cys 
        115                 120                 125             


Phe Glu Glu Ala Leu Gln Asp Ala Leu Glu Ala Leu Lys Ala Ala Trp 
    130                 135                 140                 


Asp Leu Pro Leu Leu Pro Val Asp Asn Asn Leu Asn Arg Pro Phe Val 
145                 150                 155                 160 


Asp Val Trp Trp Pro Ile Arg Cys His Ser Ala Glu Ser Leu Arg Gln 
                165                 170                 175     


Ser Phe Val Ser Asp Ser Ala Gly Leu Ala Asp Glu Ile Phe Asp Gln 
            180                 185                 190         


Leu Ala Asp Ser Leu Leu Asp Arg Leu Cys Ala Leu Gly Asp Gln Val 
        195                 200                 205             


Leu Trp Glu Ala Phe Asn Lys Glu Arg Thr Pro Gly Thr Met Leu Leu 
    210                 215                 220                 


Ala His Leu Gly Ala Ala Gly Asp Gly Ser Gly Pro Pro Val Arg Glu 
225                 230                 235                 240 


His Tyr Glu Arg Phe Ile Gln Ser His Arg Arg Asn Gly Leu Ala Pro 
                245                 250                 255     


Leu Leu Lys Glu Phe Pro Val Leu Gly Arg Leu Ile Gly Thr Val Leu 
            260                 265                 270         


Ser Leu Trp Phe Gln Gly Ser Val Glu Met Leu Gln Arg Ile Cys Ala 
        275                 280                 285             


Asp Arg Thr Val Leu Gln Gln Cys Phe Ala Ile Pro Cys Gly His His 
    290                 295                 300                 


Leu Lys Thr Val Lys Gln Gly Leu Ser Asp Pro His Arg Gly Gly Arg 
305                 310                 315                 320 


Ala Val Ala Val Leu Glu Phe Ala Asp Pro Asn Ser Thr Ala Asn Ser 
                325                 330                 335     


Ser Met His Val Val Tyr Lys Pro Lys Asp Met Ala Val Asp Ala Ala 
            340                 345                 350         


Tyr Gln Ala Thr Leu Ala Asp Leu Asn Thr His Ser Asp Leu Ser Pro 
        355                 360                 365             


Leu Arg Thr Leu Ala Ile His Asn Gly Asn Gly Tyr Gly Tyr Met Glu 
    370                 375                 380                 


His Val Val His His Leu Cys Ala Asn Asp Lys Glu Leu Thr Asn Phe 
385                 390                 395                 400 


Tyr Phe Asn Ala Gly Arg Leu Thr Ala Leu Leu His Leu Leu Gly Cys 
                405                 410                 415     


Thr Asp Cys His His Glu Asn Leu Ile Ala Cys Gly Asp Gln Leu Leu 
            420                 425                 430         


Leu Ile Asp Thr Glu Thr Leu Leu Glu Ala Asp Leu Pro Asp His Ile 
        435                 440                 445             


Ser Asp Ala Ser Ser Thr Thr Ala Gln Pro Lys Pro Ser Ser Leu Gln 
    450                 455                 460                 


Lys Gln Phe Gln Arg Ser Val Leu Arg Ser Gly Leu Leu Pro Gln Trp 
465                 470                 475                 480 


Met Phe Leu Gly Glu Ser Lys Leu Ala Ile Asp Ile Ser Ala Leu Gly 
                485                 490                 495     


Met Ser Pro Pro Asn Lys Pro Glu Arg Ile Ala Leu Gly Trp Leu Gly 
            500                 505                 510         


Phe Asn Ser Asp Gly Met Met Pro Gly Arg Val Ser Gln Pro Val Glu 
        515                 520                 525             


Ile Pro Thr Ser Leu Pro Val Gly Ile Gly Glu Val Asn Pro Phe Asp 
    530                 535                 540                 


Arg Phe Leu Glu Asp Phe Cys Asp Gly Phe Ser Met Gln Ser Glu Ala 
545                 550                 555                 560 


Leu Ile Lys Leu Arg Asn Arg Trp Leu Asp Val Asn Gly Val Leu Ala 
                565                 570                 575     


His Phe Ala Gly Leu Pro Arg Arg Ile Val Leu Arg Ala Thr Arg Val 
            580                 585                 590         


Tyr Phe Thr Ile Gln Arg Gln Gln Leu Glu Pro Thr Ala Leu Arg Ser 
        595                 600                 605             


Pro Leu Ala Gln Ala Leu Lys Leu Glu Gln Leu Thr Arg Ser Phe Leu 
    610                 615                 620                 


Leu Ala Glu Ser Lys Pro Leu His Trp Pro Ile Phe Ala Ala Glu Val 
625                 630                 635                 640 


Lys Gln Met Gln His Leu Asp Ile Pro Phe Phe Thr His Leu Ile Asp 
                645                 650                 655     


Ala Asp Ala Leu Gln Leu Gly Gly Leu Glu Gln Glu Leu Pro Gly Phe 
            660                 665                 670         


Ile Gln Thr Ser Gly Leu Ala Ala Ala Tyr Glu Arg Leu Arg Asn Leu 
        675                 680                 685             


Asp Thr Asp Glu Ile Ala Phe Gln Leu Arg Leu Ile Arg Gly Ala Val 
    690                 695                 700                 


Glu Ala Arg Glu Leu His Thr Thr Pro Glu Ser Ser Pro Thr Leu Pro 
705                 710                 715                 720 


Pro Pro Ala Thr Pro Glu Ala Leu Met Ser Ser Ser Ala Glu Thr Ser 
                725                 730                 735     


Leu Glu Ala Ala Lys Arg Ile Ala His Arg Leu Leu Glu Leu Ala Ile 
            740                 745                 750         


Arg Asp Ser Gln Gly Gln Val Glu Trp Leu Gly Met Asp Leu Gly Ala 
        755                 760                 765             


Asp Gly Glu Ser Phe Ser Phe Gly Pro Val Gly Leu Ser Leu Tyr Gly 
    770                 775                 780                 


Gly Ser Ile Gly Ile Ala His Leu Leu Gln Arg Leu Gln Ala Gln Gln 
785                 790                 795                 800 


Val Ser Leu Met Asp Ala Asp Ala Ile Gln Thr Ala Ile Leu Gln Pro 
                805                 810                 815     


Leu Val Gly Leu Val Asp Gln Pro Ser Asp Asp Gly Arg Arg Arg Trp 
            820                 825                 830         


Trp Arg Asp Gln Pro Leu Gly Leu Ser Gly Cys Gly Gly Thr Leu Leu 
        835                 840                 845             


Ala Leu Thr Leu Gln Gly Glu Gln Ala Met Ala Asn Ser Leu Leu Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Phe Ile Glu Ala Asp Gln Gln Leu Asp Leu Ile 
865                 870                 875                 880 


Gly Gly Cys Ala Gly Leu Ile Gly Ser Leu Val Gln Leu Gly Thr Glu 
                885                 890                 895     


Ser Ala Leu Gln Leu Ala Leu Arg Ala Gly Asp His Leu Ile Ala Gln 
            900                 905                 910         


Gln Asn Glu Glu Gly Ala Trp Ser Ser Ser Ser Ser Gln Pro Gly Leu 
        915                 920                 925             


Leu Gly Phe Ser His Gly Thr Ala Gly Tyr Ala Ala Ala Leu Ala His 
    930                 935                 940                 


Leu His Ala Phe Ser Ala Asp Glu Arg Tyr Arg Thr Ala Ala Ala Ala 
945                 950                 955                 960 


Ala Leu Ala Tyr Glu Arg Ala Arg Phe Asn Lys Asp Ala Gly Asn Trp 
                965                 970                 975     


Pro Asp Tyr Arg Ser Ile Gly Arg Asp Ser Asp Ser Asp Glu Pro Ser 
            980                 985                 990         


Phe Met Ala Ser Trp Cys His Gly  Ala Pro Gly Ile Ala  Leu Gly Arg 
        995                 1000                 1005             


Ala Cys  Leu Trp Gly Thr Ala  Leu Trp Asp Glu Glu  Cys Thr Lys 
    1010                 1015                 1020             


Glu Ile  Gly Ile Gly Leu Gln  Thr Thr Ala Ala Val  Ser Ser Val 
    1025                 1030                 1035             


Ser Thr  Asp His Leu Cys Cys  Gly Ser Leu Gly Leu  Met Val Leu 
    1040                 1045                 1050             


Leu Glu  Met Leu Ser Ala Gly  Pro Trp Pro Ile Asp  Asn Gln Leu 
    1055                 1060                 1065             


Arg Ser  His Cys Gln Asp Val  Ala Phe Gln Tyr Arg  Leu Gln Ala 
    1070                 1075                 1080             


Leu Gln  Arg Cys Ser Ala Glu  Pro Ile Lys Leu Arg  Cys Phe Gly 
    1085                 1090                 1095             


Thr Lys  Glu Gly Leu Leu Val  Leu Pro Gly Phe Phe  Thr Gly Leu 
    1100                 1105                 1110             


Ser Gly  Met Gly Leu Ala Leu  Leu Glu Asp Asp Pro  Ser Arg Ala 
    1115                 1120                 1125             


Val Val  Ser Gln Leu Ile Ser  Ala Gly Leu Trp Pro  Thr Glu Ser 
    1130                 1135                 1140             


Ala Ser  Gly Ser Gly Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Gly 
    1145                 1150                 1155             


Ser Gly  Ser Gly Ser Thr Ser  Gly Ser Gly Ser Gly  Ser Ala Met 
    1160                 1165                 1170             


Ser Glu  Glu Gln Leu Lys Ala  Phe Ile Ala Lys Val  Gln Ala Asp 
    1175                 1180                 1185             


Thr Ser  Leu Gln Glu Gln Leu  Lys Ala Glu Gly Ala  Asp Val Val 
    1190                 1195                 1200             


Ala Ile  Ala Lys Ala Ala Gly  Phe Thr Ile Thr Thr  Glu Asp Leu 
    1205                 1210                 1215             


Asn Ser  His Arg Gln Asn Leu  Thr Asp Asp Glu Leu  Glu Gly Val 
    1220                 1225                 1230             


Ala Gly  Gly 
    1235     


<210>  160
<211>  34
<212>  PRT
<213>  Planktothrix agardhii

<400>  160

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro 
        


<210>  161
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  161

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro Ser Ala Ser Gly Ser Gly Ser Gly Ser Ala Met Thr Val Leu 
        35                  40                  45              


Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro Leu Val Val Lys 
    50                  55                  60                  


Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe Asp Thr Asp Arg 
65                  70                  75                  80  


Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly Asp Phe Glu Gly 
                85                  90                  95      


Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu Ser Glu Val Ser 
            100                 105                 110         


Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys Leu Pro Asp Ser 
        115                 120                 125             


Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu Cys Arg Leu Thr 
    130                 135                 140                 


Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His Phe Asp Pro Met 
145                 150                 155                 160 


Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln Leu Gln Ile Ala 
                165                 170                 175     


Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr Ser Asn Asn Pro 
            180                 185                 190         


Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu Gln Gly Ile Val 
        195                 200                 205             


Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu Asn Lys Glu Glu 
    210                 215                 220                 


Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp Leu Asp Asn Leu 
225                 230                 235                 240 


Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu Asn Val Pro Lys 
                245                 250                 255     


Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln Val Phe Thr Ala 
            260                 265                 270         


Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr Asp Trp Arg Lys 
        275                 280                 285             


Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr Asn Leu Pro Glu 
    290                 295                 300                 


Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr Phe Gly Leu Asn 
305                 310                 315                 320 


Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly Arg His Val Phe 
                325                 330                 335     


Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu Glu Leu Phe Ala 
            340                 345                 350         


Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile Leu Leu Thr Pro 
        355                 360                 365             


Thr Asn Gln Lys Pro Phe 
    370                 


<210>  162
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  162

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro Ser Ala Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Ser Ala Met Thr Val Leu Ile Phe Thr Phe Ser Asn 
    50                  55                  60                  


Asp Asn Glu Ser Ile Pro Leu Val Val Lys Ala Ile Glu Ala Lys Gly 
65                  70                  75                  80  


Glu Lys Ala Phe Arg Phe Asp Thr Asp Arg Phe Pro Thr Glu Val Lys 
                85                  90                  95      


Leu Asp Ile Tyr Ser Gly Asp Phe Glu Gly Gly Ile Val Thr Asp Gly 
            100                 105                 110         


Glu His Lys Leu Asp Leu Ser Glu Val Ser Ser Val Trp Tyr Arg Arg 
        115                 120                 125             


Met Arg Tyr Gly Ala Lys Leu Pro Asp Ser Met Asp Gln Gln Phe Arg 
    130                 135                 140                 


Glu Ala Ser Leu Lys Glu Cys Arg Leu Thr Val Arg Gly Leu Ile Ala 
145                 150                 155                 160 


Ser Leu Pro Gly Phe His Phe Asp Pro Met Ile Asn Val Asp Arg Ala 
                165                 170                 175     


Asn Asn Lys Gln Leu Gln Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu 
            180                 185                 190         


Thr Pro Arg Thr Leu Thr Ser Asn Asn Pro Glu Ala Val Lys Gln Phe 
        195                 200                 205             


Ala Gln Asp Cys Lys Glu Gln Gly Ile Val Thr Lys Met Leu Ser Gln 
    210                 215                 220                 


Phe Ala Ile Tyr Gly Glu Asn Lys Glu Glu Asn Val Val Phe Thr Ser 
225                 230                 235                 240 


Pro Val Thr Asp Asp Asp Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys 
                245                 250                 255     


Pro Met Thr Phe Gln Glu Asn Val Pro Lys Ala Leu Glu Leu Arg Thr 
            260                 265                 270         


Ile Ile Val Gly Lys Gln Val Phe Thr Ala Ala Ile Asn Ser Gln Gln 
        275                 280                 285             


Leu Asp Gly Ala Thr Tyr Asp Trp Arg Lys Glu Gly Arg Ala Leu His 
    290                 295                 300                 


Glu Lys Trp Gln Ala Tyr Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu 
305                 310                 315                 320 


Leu Gln Leu Thr Ala Tyr Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile 
                325                 330                 335     


Ile Val Thr Pro Asp Gly Arg His Val Phe Leu Glu Ile Asn Pro Val 
            340                 345                 350         


Gly Glu Phe Phe Trp Leu Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser 
        355                 360                 365             


Gln Ala Ile Ala Glu Ile Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe 
    370                 375                 380                 


<210>  163
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  163

Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe 
1               5                   10                  15      


Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser 
            20                  25                  30          


Ala Pro Ser Ala Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Ser Gly Ser Thr Ser Gly Ser Gly Ser Gly Ser Ala 
    50                  55                  60                  


Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
65                  70                  75                  80  


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
                85                  90                  95      


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
            100                 105                 110         


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
        115                 120                 125             


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
    130                 135                 140                 


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
145                 150                 155                 160 


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
                165                 170                 175     


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
            180                 185                 190         


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
        195                 200                 205             


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
    210                 215                 220                 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
225                 230                 235                 240 


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
                245                 250                 255     


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
            260                 265                 270         


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
        275                 280                 285             


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
    290                 295                 300                 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
305                 310                 315                 320 


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
                325                 330                 335     


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
            340                 345                 350         


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
        355                 360                 365             


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
    370                 375                 380                 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe 
385                 390                 


<210>  164
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  164

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
145                 150                 155                 160 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
                165                 170                 175     


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
    210                 215                 220                 


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
                245                 250                 255     


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
        275                 280                 285             


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
305                 310                 315                 320 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe Ser Ala Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Ser Ala Met Ser Lys Asn Val Lys Val Ser Ala Pro Lys Ala 
            340                 345                 350         


Val Pro Phe Phe Ala Arg Phe Leu Ala Glu Gln Ala Val Glu Ala Asn 
        355                 360                 365             


Asn Ser Asn Ser Ala Pro Glu Phe Ala Leu 
    370                 375             


<210>  165
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  165

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
145                 150                 155                 160 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
                165                 170                 175     


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
    210                 215                 220                 


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
                245                 250                 255     


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
        275                 280                 285             


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
305                 310                 315                 320 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe Ser Ala Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Ser Thr Ser Gly Ser Gly Ser Gly Ser Ala Met Ser 
            340                 345                 350         


Lys Asn Val Lys Val Ser Ala Pro Lys Ala Val Pro Phe Phe Ala Arg 
        355                 360                 365             


Phe Leu Ala Glu Gln Ala Val Glu Ala Asn Asn Ser Asn Ser Ala Pro 
    370                 375                 380                 


Glu Phe Ala Leu 
385             


<210>  166
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme-Leader-Fusion

<400>  166

Met Thr Val Leu Ile Phe Thr Phe Ser Asn Asp Asn Glu Ser Ile Pro 
1               5                   10                  15      


Leu Val Val Lys Ala Ile Glu Ala Lys Gly Glu Lys Ala Phe Arg Phe 
            20                  25                  30          


Asp Thr Asp Arg Phe Pro Thr Glu Val Lys Leu Asp Ile Tyr Ser Gly 
        35                  40                  45              


Asp Phe Glu Gly Gly Ile Val Thr Asp Gly Glu His Lys Leu Asp Leu 
    50                  55                  60                  


Ser Glu Val Ser Ser Val Trp Tyr Arg Arg Met Arg Tyr Gly Ala Lys 
65                  70                  75                  80  


Leu Pro Asp Ser Met Asp Gln Gln Phe Arg Glu Ala Ser Leu Lys Glu 
                85                  90                  95      


Cys Arg Leu Thr Val Arg Gly Leu Ile Ala Ser Leu Pro Gly Phe His 
            100                 105                 110         


Phe Asp Pro Met Ile Asn Val Asp Arg Ala Asn Asn Lys Gln Leu Gln 
        115                 120                 125             


Leu Gln Ile Ala Arg Gln Leu Gly Leu Leu Thr Pro Arg Thr Leu Thr 
    130                 135                 140                 


Ser Asn Asn Pro Glu Ala Val Lys Gln Phe Ala Gln Asp Cys Lys Glu 
145                 150                 155                 160 


Gln Gly Ile Val Thr Lys Met Leu Ser Gln Phe Ala Ile Tyr Gly Glu 
                165                 170                 175     


Asn Lys Glu Glu Asn Val Val Phe Thr Ser Pro Val Thr Asp Asp Asp 
            180                 185                 190         


Leu Asp Asn Leu Glu Gly Leu Ser Phe Cys Pro Met Thr Phe Gln Glu 
        195                 200                 205             


Asn Val Pro Lys Ala Leu Glu Leu Arg Thr Ile Ile Val Gly Lys Gln 
    210                 215                 220                 


Val Phe Thr Ala Ala Ile Asn Ser Gln Gln Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Trp Arg Lys Glu Gly Arg Ala Leu His Glu Lys Trp Gln Ala Tyr 
                245                 250                 255     


Asn Leu Pro Glu Asp Ile Glu Lys Lys Leu Leu Gln Leu Thr Ala Tyr 
            260                 265                 270         


Phe Gly Leu Asn Tyr Gly Ala Ile Asp Ile Ile Val Thr Pro Asp Gly 
        275                 280                 285             


Arg His Val Phe Leu Glu Ile Asn Pro Val Gly Glu Phe Phe Trp Leu 
    290                 295                 300                 


Glu Leu Phe Ala Pro Tyr Phe Pro Ile Ser Gln Ala Ile Ala Glu Ile 
305                 310                 315                 320 


Leu Leu Thr Pro Thr Asn Gln Lys Pro Phe Ser Ala Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Ser Ala Met Ser Lys Asn Val Lys Val Ser 
        355                 360                 365             


Ala Pro Lys Ala Val Pro Phe Phe Ala Arg Phe Leu Ala Glu Gln Ala 
    370                 375                 380                 


Val Glu Ala Asn Asn Ser Asn Ser Ala Pro Glu Phe Ala Leu 
385                 390                 395             


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  167

Ser Ala Ser Gly Ser Gly Ser Gly Ser Ala 
1               5                   10  


<210>  168
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  168

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Ala 
            20          


<210>  169
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  169

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ala 
            20                  25                  30          


<210>  170
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  170

Ser Ala Ser Gly Ser Gly Ser Gly Ser Gly Ser Thr Ser Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Ala 
            20  


<210>  171
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  171

Ser Ala Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
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Ser Gly Ser Gly Ser Thr Ser Gly Ser Gly Ser Gly Ser Ala 
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