                         SEQUENCE LISTING

<110>  Helmholtz Zentrum fr Infektionsforschung
 
<120>  Methods and compositions of carrier systems for the purpose of 
       intracellular drug targeting

<130>  743-2 PCT

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  969
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  InvA YPK_2429
<222>  (1)..(969)

<400>  1

Met Ser Met Tyr Phe Asn Lys Ile Ile Ser Phe Asn Ile Ile Ser Arg 
1               5                   10                  15      


Ile Val Ile Cys Ile Phe Leu Ile Cys Gly Met Phe Met Ala Gly Ala 
            20                  25                  30          


Ser Glu Lys Tyr Asp Ala Asn Ala Pro Gln Gln Val Gln Pro Tyr Ser 
        35                  40                  45              


Val Ser Ser Ser Ala Phe Glu Asn Leu His Pro Asn Asn Glu Met Glu 
    50                  55                  60                  


Ser Ser Ile Asn Pro Phe Ser Ala Ser Asp Thr Glu Arg Asn Ala Ala 
65                  70                  75                  80  


Ile Ile Asp Arg Ala Asn Lys Glu Gln Glu Thr Glu Ala Val Asn Lys 
                85                  90                  95      


Met Ile Ser Thr Gly Ala Arg Leu Ala Ala Ser Gly Arg Ala Ser Asp 
            100                 105                 110         


Val Ala His Ser Met Val Gly Asp Ala Val Asn Gln Glu Ile Lys Gln 
        115                 120                 125             


Trp Leu Asn Arg Phe Gly Thr Ala Gln Val Asn Leu Asn Phe Asp Lys 
    130                 135                 140                 


Asn Phe Ser Leu Lys Glu Ser Ser Leu Asp Trp Leu Ala Pro Trp Tyr 
145                 150                 155                 160 


Asp Ser Ala Ser Phe Leu Phe Phe Ser Gln Leu Gly Ile Arg Asn Lys 
                165                 170                 175     


Asp Ser Arg Asn Thr Leu Asn Leu Gly Val Gly Ile Arg Thr Leu Glu 
            180                 185                 190         


Asn Gly Trp Leu Tyr Gly Leu Asn Thr Phe Tyr Asp Asn Asp Leu Thr 
        195                 200                 205             


Gly His Asn His Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp Tyr 
    210                 215                 220                 


Leu Gln Leu Ala Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His Ser 
225                 230                 235                 240 


Ser Arg Asp Phe Ser Asp Tyr Lys Glu Arg Pro Ala Thr Gly Gly Asp 
                245                 250                 255     


Leu Arg Ala Asn Ala Tyr Leu Pro Ala Leu Pro Gln Leu Gly Gly Lys 
            260                 265                 270         


Leu Met Tyr Glu Gln Tyr Thr Gly Glu Arg Val Ala Leu Phe Gly Lys 
        275                 280                 285             


Asp Asn Leu Gln Arg Asn Pro Tyr Ala Val Thr Ala Gly Ile Asn Tyr 
    290                 295                 300                 


Thr Pro Val Pro Leu Leu Thr Val Gly Val Asp Gln Arg Met Gly Lys 
305                 310                 315                 320 


Ser Ser Lys His Glu Thr Gln Trp Asn Leu Gln Met Asn Tyr Arg Leu 
                325                 330                 335     


Gly Glu Ser Phe Gln Ser Gln Leu Ser Pro Ser Ala Val Ala Gly Thr 
            340                 345                 350         


Arg Leu Leu Ala Glu Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn Asn 
        355                 360                 365             


Ile Val Leu Glu Tyr Gln Lys Gln Gln Val Val Lys Leu Thr Leu Ser 
    370                 375                 380                 


Pro Ala Thr Ile Ser Gly Leu Pro Gly Gln Val Tyr Gln Val Asn Ala 
385                 390                 395                 400 


Gln Val Gln Gly Ala Ser Ala Val Arg Glu Ile Val Trp Ser Asp Ala 
                405                 410                 415     


Glu Leu Ile Ala Ala Gly Gly Thr Leu Thr Pro Leu Ser Thr Thr Gln 
            420                 425                 430         


Phe Asn Leu Val Leu Pro Pro Tyr Lys Arg Thr Ala Gln Val Ser Arg 
        435                 440                 445             


Val Thr Asp Asp Leu Thr Ala Asn Phe Tyr Ser Leu Ser Ala Leu Ala 
    450                 455                 460                 


Val Asp His Gln Gly Asn Arg Ser Asn Ser Phe Thr Leu Ser Val Thr 
465                 470                 475                 480 


Val Gln Gln Pro Gln Leu Thr Leu Thr Ala Ala Val Ile Gly Asp Gly 
                485                 490                 495     


Ala Pro Ala Asn Gly Lys Thr Ala Ile Thr Val Glu Phe Thr Val Ala 
            500                 505                 510         


Asp Phe Glu Gly Lys Pro Leu Ala Gly Gln Glu Val Val Ile Thr Thr 
        515                 520                 525             


Asn Asn Gly Ala Leu Pro Asn Lys Ile Thr Glu Lys Thr Asp Ala Asn 
    530                 535                 540                 


Gly Val Ala Arg Ile Ala Leu Thr Asn Thr Thr Asp Gly Val Thr Val 
545                 550                 555                 560 


Val Thr Ala Glu Val Glu Gly Gln Arg Gln Ser Val Asp Thr His Phe 
                565                 570                 575     


Val Lys Gly Thr Ile Ala Ala Asp Lys Ser Thr Leu Ala Ala Val Pro 
            580                 585                 590         


Thr Ser Ile Ile Ala Asp Gly Leu Met Ala Ser Thr Ile Thr Leu Glu 
        595                 600                 605             


Leu Lys Asp Thr Tyr Gly Asp Pro Gln Ala Gly Ala Asn Val Ala Phe 
    610                 615                 620                 


Asp Thr Thr Leu Gly Asn Met Gly Val Ile Thr Asp His Asn Asp Gly 
625                 630                 635                 640 


Thr Tyr Ser Ala Pro Leu Thr Ser Thr Thr Leu Gly Val Ala Thr Val 
                645                 650                 655     


Thr Val Lys Val Asp Gly Ala Ala Phe Ser Val Pro Ser Val Thr Val 
            660                 665                 670         


Asn Phe Thr Ala Asp Pro Ile Pro Asp Ala Gly Arg Ser Ser Phe Thr 
        675                 680                 685             


Val Ser Thr Pro Asp Ile Leu Ala Asp Gly Thr Met Ser Ser Thr Leu 
    690                 695                 700                 


Ser Phe Val Pro Val Asp Lys Asn Gly His Phe Ile Ser Gly Met Gln 
705                 710                 715                 720 


Gly Leu Ser Phe Thr Gln Asn Gly Val Pro Val Ser Ile Ser Pro Ile 
                725                 730                 735     


Thr Glu Gln Pro Asp Ser Tyr Thr Ala Thr Val Val Gly Asn Ser Val 
            740                 745                 750         


Gly Asp Val Thr Ile Thr Pro Gln Val Asp Thr Leu Ile Leu Ser Thr 
        755                 760                 765             


Leu Gln Lys Lys Ile Ser Leu Phe Pro Val Pro Thr Leu Thr Gly Ile 
    770                 775                 780                 


Leu Val Asn Gly Gln Asn Phe Ala Thr Asp Lys Gly Phe Pro Lys Thr 
785                 790                 795                 800 


Ile Phe Lys Asn Ala Thr Phe Gln Leu Gln Met Asp Asn Asp Val Ala 
                805                 810                 815     


Asn Asn Thr Gln Tyr Glu Trp Ser Ser Ser Phe Thr Pro Asn Val Ser 
            820                 825                 830         


Val Asn Asp Gln Gly Gln Val Thr Ile Thr Tyr Gln Thr Tyr Ser Glu 
        835                 840                 845             


Val Ala Val Thr Ala Lys Ser Lys Lys Phe Pro Ser Tyr Ser Val Ser 
    850                 855                 860                 


Tyr Arg Phe Tyr Pro Asn Arg Trp Ile Tyr Asp Gly Gly Arg Ser Leu 
865                 870                 875                 880 


Val Ser Ser Leu Glu Ala Ser Arg Gln Cys Gln Gly Ser Asp Met Ser 
                885                 890                 895     


Ala Val Leu Glu Ser Ser Arg Ala Thr Asn Gly Thr Arg Ala Pro Asp 
            900                 905                 910         


Gly Thr Leu Trp Gly Glu Trp Gly Ser Leu Thr Ala Tyr Ser Ser Asp 
        915                 920                 925             


Trp Gln Ser Gly Glu Tyr Trp Val Lys Lys Thr Ser Thr Asp Phe Glu 
    930                 935                 940                 


Thr Met Asn Met Asp Thr Gly Ala Leu Gln Pro Gly Pro Ala Tyr Leu 
945                 950                 955                 960 


Ala Phe Pro Leu Cys Ala Leu Ser Ile 
                965                 


<210>  2
<211>  480
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  pAK01aa 490-987 for overexpression
<222>  (1)..(480)

<400>  2

Ala Ala Val Ile Gly Asp Gly Ala Pro Ala Asn Gly Lys Thr Ala Ile 
1               5                   10                  15      


Thr Val Glu Phe Thr Val Ala Asp Phe Glu Gly Lys Pro Leu Ala Gly 
            20                  25                  30          


Gln Glu Val Val Ile Thr Thr Asn Asn Gly Ala Leu Pro Asn Lys Ile 
        35                  40                  45              


Thr Glu Lys Thr Asp Ala Asn Gly Val Ala Arg Ile Ala Leu Thr Asn 
    50                  55                  60                  


Thr Thr Asp Gly Val Thr Val Val Thr Ala Glu Val Glu Gly Gln Arg 
65                  70                  75                  80  


Gln Ser Val Asp Thr His Phe Val Lys Gly Thr Ile Ala Ala Asp Lys 
                85                  90                  95      


Ser Thr Leu Ala Ala Val Pro Thr Ser Ile Ile Ala Asp Gly Leu Met 
            100                 105                 110         


Ala Ser Thr Ile Thr Leu Glu Leu Lys Asp Thr Tyr Gly Asp Pro Gln 
        115                 120                 125             


Ala Gly Ala Asn Val Ala Phe Asp Thr Thr Leu Gly Asn Met Gly Val 
    130                 135                 140                 


Ile Thr Asp His Asn Asp Gly Thr Tyr Ser Ala Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Thr Leu Gly Val Ala Thr Val Thr Val Lys Val Asp Gly Ala Ala Phe 
                165                 170                 175     


Ser Val Pro Ser Val Thr Val Asn Phe Thr Ala Asp Pro Ile Pro Asp 
            180                 185                 190         


Ala Gly Arg Ser Ser Phe Thr Val Ser Thr Pro Asp Ile Leu Ala Asp 
        195                 200                 205             


Gly Thr Met Ser Ser Thr Leu Ser Phe Val Pro Val Asp Lys Asn Gly 
    210                 215                 220                 


His Phe Ile Ser Gly Met Gln Gly Leu Ser Phe Thr Gln Asn Gly Val 
225                 230                 235                 240 


Pro Val Ser Ile Ser Pro Ile Thr Glu Gln Pro Asp Ser Tyr Thr Ala 
                245                 250                 255     


Thr Val Val Gly Asn Ser Val Gly Asp Val Thr Ile Thr Pro Gln Val 
            260                 265                 270         


Asp Thr Leu Ile Leu Ser Thr Leu Gln Lys Lys Ile Ser Leu Phe Pro 
        275                 280                 285             


Val Pro Thr Leu Thr Gly Ile Leu Val Asn Gly Gln Asn Phe Ala Thr 
    290                 295                 300                 


Asp Lys Gly Phe Pro Lys Thr Ile Phe Lys Asn Ala Thr Phe Gln Leu 
305                 310                 315                 320 


Gln Met Asp Asn Asp Val Ala Asn Asn Thr Gln Tyr Glu Trp Ser Ser 
                325                 330                 335     


Ser Phe Thr Pro Asn Val Ser Val Asn Asp Gln Gly Gln Val Thr Ile 
            340                 345                 350         


Thr Tyr Gln Thr Tyr Ser Glu Val Ala Val Thr Ala Lys Ser Lys Lys 
        355                 360                 365             


Phe Pro Ser Tyr Ser Val Ser Tyr Arg Phe Tyr Pro Asn Arg Trp Ile 
    370                 375                 380                 


Tyr Asp Gly Gly Arg Ser Leu Val Ser Ser Leu Glu Ala Ser Arg Gln 
385                 390                 395                 400 


Cys Gln Gly Ser Asp Met Ser Ala Val Leu Glu Ser Ser Arg Ala Thr 
                405                 410                 415     


Asn Gly Thr Arg Ala Pro Asp Gly Thr Leu Trp Gly Glu Trp Gly Ser 
            420                 425                 430         


Leu Thr Ala Tyr Ser Ser Asp Trp Gln Ser Gly Glu Tyr Trp Val Lys 
        435                 440                 445             


Lys Thr Ser Thr Asp Phe Glu Thr Met Asn Met Asp Thr Gly Ala Leu 
    450                 455                 460                 


Gln Pro Gly Pro Ala Tyr Leu Ala Phe Pro Leu Cys Ala Leu Ser Ile 
465                 470                 475                 480 


<210>  3
<211>  1075
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  InvB YPK_2513
<222>  (1)..(1075)

<400>  3

Met Ser Leu Tyr Arg Ile Ser Ser Leu His Gln Ala Lys Gln Leu Asn 
1               5                   10                  15      


Lys Asn Lys Gln Leu Asn Lys Thr Arg Ile Ser Lys Ser Val Val Trp 
            20                  25                  30          


Ala Asn Ile Val Ile Gln Ala Ile Phe Pro Leu Ser Ile Ala Phe Thr 
        35                  40                  45              


Pro Ala Val Met Ala Ala Glu Thr Val Gly Ala Ser Asp Glu Lys Pro 
    50                  55                  60                  


Arg Ser Ala Ser Gln Ala Glu Gln Ser Thr Ala Asn Ala Ala Thr Arg 
65                  70                  75                  80  


Leu Ala Ser Ile Leu Thr Asn Asp Asp Ser Ala Lys Gln Ala Ser Ser 
                85                  90                  95      


Ile Ala Arg Gly Thr Ala Ala Asn Ala Gly Asn Glu Ala Leu Gln Lys 
            100                 105                 110         


Trp Phe Asn Gln Phe Gly Ser Ala Lys Val Gln Leu Asn Leu Asp Glu 
        115                 120                 125             


Lys Leu Ser Leu Lys Gly Ser Gln Leu Asp Val Leu Leu Pro Leu Thr 
    130                 135                 140                 


Asp Ser Pro Asp Leu Leu Thr Phe Thr Gln Leu Gly Gly Arg Tyr Ile 
145                 150                 155                 160 


Asp Asp Arg Val Thr Leu Asn Val Gly Leu Gly Gln Arg His Phe Phe 
                165                 170                 175     


Ala Gln Gln Met Leu Gly Tyr Asn Leu Phe Val Asp His Asp Ala Ser 
            180                 185                 190         


Tyr Ser His Thr Arg Ile Gly Val Gly Ala Glu Tyr Gly Arg Asp Phe 
        195                 200                 205             


Ile Asn Leu Ala Ala Asn Gly Tyr Phe Gly Val Ser Gly Trp Lys Asn 
    210                 215                 220                 


Ser Pro Asp Leu Asp Lys Tyr Asp Glu Lys Val Ala Asn Gly Phe Asp 
225                 230                 235                 240 


Leu Arg Ser Glu Ala Tyr Leu Pro Thr Leu Pro Gln Leu Gly Gly Lys 
                245                 250                 255     


Leu Ile Tyr Glu Gln Tyr Phe Gly Asp Glu Val Gly Leu Phe Gly Val 
            260                 265                 270         


Asp Asn Arg Gln Lys Asn Pro Leu Ala Val Thr Leu Gly Val Asn Tyr 
        275                 280                 285             


Thr Pro Ile Pro Leu Phe Thr Val Gly Val Asp His Lys Met Gly Arg 
    290                 295                 300                 


Ala Gly Met Asn Asp Thr Arg Phe Asn Leu Gly Phe Asn Tyr Ala Phe 
305                 310                 315                 320 


Gly Thr Pro Leu Ala His Gln Leu Asp Ser Asp Ala Val Ala Ile Lys 
                325                 330                 335     


Arg Ser Leu Met Gly Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn Gln 
            340                 345                 350         


Ile Val Met Lys Tyr Arg Lys Gln Asn Arg Val Thr Leu Glu Leu Pro 
        355                 360                 365             


Ala Arg Val Ser Gly Ala Ala Arg Gln Thr Met Pro Leu Val Ala Asn 
    370                 375                 380                 


Ala Thr Ala Gln Gln Gly Ile Asp Arg Ile Glu Trp Glu Ala Ser Ala 
385                 390                 395                 400 


Leu Thr Leu Ala Gly Gly Lys Ile Thr Gly Ser Gly Asn Asn Trp Gln 
                405                 410                 415     


Ile Thr Leu Pro Ser Tyr Leu Ser Gly Gly Glu Gly Asn Asn Thr Tyr 
            420                 425                 430         


Arg Ile Ser Ala Ile Ala Tyr Asp Thr Leu Gly Asn Ala Ser Pro Val 
        435                 440                 445             


Ala Tyr Ser Asp Leu Val Val Asp Ser His Gly Val Asn Thr Asn Ala 
    450                 455                 460                 


Ser Gly Leu Thr Ala Ala Pro Glu Ile Leu Pro Ala Asn Ala Ser Ala 
465                 470                 475                 480 


Ser Ser Val Ile Glu Phe Asn Ile Lys Asp Asn Ala Asn Gln Pro Ile 
                485                 490                 495     


Thr Gly Ile Ala Asp Glu Leu Ala Phe Ser Leu Glu Leu Val Glu Leu 
            500                 505                 510         


Pro Glu Glu Leu Ala Lys Ala Lys Ala Arg Ser Val Pro Leu Lys Thr 
        515                 520                 525             


Val Ser His Thr Leu Thr Lys Ile Thr Glu Ser Ala Pro Gly Ile Tyr 
    530                 535                 540                 


Gln Ala Thr Leu Thr Ser Gly Ser Lys Pro Gln Leu Ile Asn Ile Thr 
545                 550                 555                 560 


Ala Gln Ile Asn Gly Val Pro Leu Ala Asp Val Gln Thr Lys Val Thr 
                565                 570                 575     


Leu Ile Ala Asp Glu Asn Thr Ala Thr Leu Gln Thr Ser Ser Leu Gln 
            580                 585                 590         


Ile Ile Thr Asn Gly Ser Leu Ala Asp Asp Thr Asp Ala Asn Gln Ile 
        595                 600                 605             


Arg Ala Val Val Val Asp Ala Tyr Gly Asn Lys Leu Ser Gly Val Gln 
    610                 615                 620                 


Val Asn Phe Thr Val Gly Asn Asn Ala Lys Ile Thr Glu Thr Thr Leu 
625                 630                 635                 640 


Ser Asp Lys Gln Gly Gly Val Thr Ala Ala Ile Thr Ser Thr Lys Ala 
                645                 650                 655     


Gly Thr Tyr Thr Val Thr Ala Glu Leu Asn Gly Val Thr Gln Gln Ile 
            660                 665                 670         


Asp Val Asn Phe Ile Pro Asp Ala Gly Thr Ala Thr Leu Asp Asp Ser 
        675                 680                 685             


Asp Glu Tyr Lys Leu Gln Trp Val Thr Asn Gly Gln Val Ala Asp Gly 
    690                 695                 700                 


Glu Ser Thr Asn Ser Val Gln Leu Thr Val Val Asp Lys Phe Gly Asn 
705                 710                 715                 720 


Thr Val Pro Gly Val Asp Val Ala Phe Thr Thr Asp Ile Gly Ala Ile 
                725                 730                 735     


Ile Ser Glu Val Thr Pro Thr Asp Ala Asn Gly Val Ala Thr Ala Lys 
            740                 745                 750         


Ile Ile Ser Ser Gln Ala Lys Ser His Thr Val Lys Ala Thr Leu Asn 
        755                 760                 765             


Arg Lys Glu Gln Thr Val Glu Val Asn Phe Ile Ala Asp Thr Ala Thr 
    770                 775                 780                 


Ala Glu Ile Thr Ala Asn Asn Phe Thr Val Glu Val Asp Gly Gln Val 
785                 790                 795                 800 


Ala Gly Ser Gly Thr Asn Gln Val Gln Ala Leu Val Val Asp Lys Lys 
                805                 810                 815     


Gly Asn Pro Val Ala Asn Met Thr Val Asn Phe Thr Ala Thr Asn Gly 
            820                 825                 830         


Val Val Ala Glu Thr Thr Ser Ala Lys Thr Asp Glu Asn Gly Lys Val 
        835                 840                 845             


Thr Thr Asn Leu Ser Met Thr Asn Val Gly Gly Thr Ile Ser Thr Val 
    850                 855                 860                 


Thr Ala Thr Met Ile Asn Ser Ala Asn Val Thr Ser Thr Gln Asp Lys 
865                 870                 875                 880 


Pro Val Ile Phe Tyr Pro Asp Phe Thr Lys Ala Thr Leu Asn Thr Pro 
                885                 890                 895     


Ala Asn Thr Tyr Ser Gly Phe Asn Ile Asn Ser Gly Phe Pro Thr Thr 
            900                 905                 910         


Gly Phe Lys Asn Thr His Phe Gln Leu Ser Pro His Gly Ile Thr Gly 
        915                 920                 925             


Ala Asn Ser Asp Tyr Asp Trp Val Ser Ser His Pro Asn Val Ser Val 
    930                 935                 940                 


Ser Asn Thr Gly Ala Ile Thr Leu Gln Asp Asn Pro Gly Gly Lys Val 
945                 950                 955                 960 


Thr Ile Thr Ala Thr Trp Lys His Asp Ser Ser Lys Val Phe Thr Tyr 
                965                 970                 975     


Asp Phe Thr Leu Asn Tyr Trp Val Gly Leu Tyr Ser Ser Thr Asn Leu 
            980                 985                 990         


Ser Trp Ala Gln Ala Asn Ala Ser  Cys Ile Asn Ala Gly  Met Arg Leu 
        995                 1000                 1005             


Pro Thr  Asn Ser Glu Val Ser  Ala Gly Gln Asp Val  Arg Gly Val 
    1010                 1015                 1020             


Gly Ser  Leu Phe Gly Glu Trp  Gly Asn Leu Asn Ala  Tyr Pro Ser 
    1025                 1030                 1035             


Phe Pro  Thr Ala Gln Ile Ile  Trp Thr Ser Val Asp  Thr Asn Asp 
    1040                 1045                 1050             


Phe His  Ile Asp Thr Gly Leu  Thr His Ser Ala Ser  Asn Val Thr 
    1055                 1060                 1065             


Leu Ala  Tyr Met Cys Ile Lys  
    1070                 1075 


<210>  4
<211>  5337
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  InvC YPK_0145
<222>  (01)..(5337)

<400>  4

Met Leu Asn Tyr Phe Arg Ala Ile Leu Ile Ser Trp Lys Trp Lys Leu 
1               5                   10                  15      


Ser His His Thr Ser Arg Pro His Asp Val Lys Glu Lys Gly His Pro 
            20                  25                  30          


Arg Lys Ile Lys Val Val Ala Trp Ile Thr Leu Phe Phe Gln Phe Ala 
        35                  40                  45              


Phe Pro Leu Ser Leu Ser Phe Thr Pro Ala Ile Ala Ala Ala Asn Thr 
    50                  55                  60                  


Thr Asn Ser Ala Pro Thr Ser Val Ile Thr Pro Val Asn Ala Ser Ile 
65                  70                  75                  80  


Leu Pro Pro Ala Ala Arg Ala Thr Glu Pro Tyr Thr Leu Gly Pro Gly 
                85                  90                  95      


Asp Ser Ile Gln Ser Ile Ala Lys Lys Tyr Asn Ile Thr Val Asp Glu 
            100                 105                 110         


Leu Lys Lys Leu Asn Ala Tyr Arg Thr Phe Ser Lys Pro Phe Ala Ser 
        115                 120                 125             


Leu Thr Thr Gly Asp Glu Ile Glu Val Pro Arg Lys Glu Ser Ser Phe 
    130                 135                 140                 


Phe Ser Asn Asn Pro Asn Glu Asn Asn Lys Lys Asp Val Asp Asp Leu 
145                 150                 155                 160 


Leu Ala Arg Asn Ala Met Gly Ala Gly Lys Leu Leu Ser Asn Asp Asn 
                165                 170                 175     


Thr Ser Asp Ala Ala Ser Asn Met Ala Arg Ser Ala Val Thr Asn Glu 
            180                 185                 190         


Ile Asn Ala Ser Ser Gln Gln Trp Leu Asn Gln Phe Gly Thr Ala Arg 
        195                 200                 205             


Val Gln Leu Asn Val Asp Ser Asp Phe Lys Leu Asp Asn Ser Ala Leu 
    210                 215                 220                 


Asp Leu Leu Val Pro Leu Lys Asp Ser Glu Ser Ser Leu Leu Phe Thr 
225                 230                 235                 240 


Gln Leu Gly Val Arg Asn Lys Asp Ser Arg Asn Thr Val Asn Ile Gly 
                245                 250                 255     


Ala Gly Ile Arg Gln Tyr Gln Gly Asp Trp Met Tyr Gly Ala Asn Thr 
            260                 265                 270         


Phe Phe Asp Asn Asp Leu Thr Gly Lys Asn Arg Arg Val Gly Val Gly 
        275                 280                 285             


Ala Glu Val Ala Thr Asp Tyr Leu Lys Phe Ser Ala Asn Thr Tyr Phe 
    290                 295                 300                 


Gly Leu Thr Gly Trp His Gln Ser Arg Asp Phe Ser Ser Tyr Asp Glu 
305                 310                 315                 320 


Arg Pro Ala Asp Gly Phe Asp Ile Arg Thr Glu Ala Tyr Leu Pro Ala 
                325                 330                 335     


Tyr Pro Gln Leu Gly Gly Lys Leu Met Tyr Glu Lys Tyr Arg Gly Asp 
            340                 345                 350         


Glu Val Ala Leu Phe Gly Lys Asp Asp Arg Gln Lys Asp Pro His Ala 
        355                 360                 365             


Val Thr Leu Gly Val Asn Tyr Thr Pro Val Pro Leu Val Thr Ile Gly 
    370                 375                 380                 


Ala Glu His Arg Glu Gly Lys Gly Asn Asn Asn Asn Thr Ser Val Asn 
385                 390                 395                 400 


Val Gln Leu Asn Tyr Arg Met Gly Gln Pro Trp Asn Asp Gln Ile Asp 
                405                 410                 415     


Gln Ser Ala Val Ala Ala Asn Arg Thr Leu Ala Gly Ser Arg Tyr Asp 
            420                 425                 430         


Leu Val Glu Arg Asn Asn Asn Ile Val Leu Asp Tyr Lys Lys Gln Glu 
        435                 440                 445             


Leu Ile His Leu Val Leu Pro Asp Arg Ile Ser Gly Ser Gly Gly Gly 
    450                 455                 460                 


Ala Ile Thr Leu Thr Ala Gln Val Arg Ala Lys Tyr Gly Phe Ser Arg 
465                 470                 475                 480 


Ile Glu Trp Asp Ala Thr Pro Leu Glu Asn Ala Gly Gly Ser Thr Ser 
                485                 490                 495     


Pro Leu Thr Gln Ser Ser Leu Ser Val Thr Leu Pro Phe Tyr Gln His 
            500                 505                 510         


Ile Leu Arg Thr Ser Asn Thr His Thr Ile Ser Ala Val Ala Tyr Asp 
        515                 520                 525             


Ala Gln Gly Asn Ala Ser Asn Arg Ala Val Thr Ser Ile Glu Val Thr 
    530                 535                 540                 


Arg Pro Glu Thr Met Val Ile Ser His Leu Ala Thr Thr Val Asp Asn 
545                 550                 555                 560 


Ala Thr Ala Asn Gly Ile Ala Ala Asn Thr Val Gln Ala Thr Val Thr 
                565                 570                 575     


Asp Gly Asp Gly Gln Pro Ile Ile Gly Gln Ile Ile Asn Phe Ala Val 
            580                 585                 590         


Asn Thr Gln Ala Thr Leu Ser Thr Thr Glu Ala Arg Thr Gly Ala Asn 
        595                 600                 605             


Gly Ile Ala Ser Thr Thr Leu Thr His Thr Val Ala Gly Val Ser Ala 
    610                 615                 620                 


Val Ser Ala Thr Leu Gly Ser Ser Ser Arg Ser Val Asn Thr Thr Phe 
625                 630                 635                 640 


Val Ala Asp Glu Ser Thr Ala Glu Ile Thr Ala Ala Asn Leu Thr Val 
                645                 650                 655     


Thr Thr Asn Asp Ser Val Ala Asn Gly Ser Asp Thr Asn Ala Val Arg 
            660                 665                 670         


Ala Lys Val Thr Asp Ala Tyr Thr Asn Ala Val Ala Asn Gln Ser Val 
        675                 680                 685             


Ile Phe Ser Ala Ser Asn Gly Ala Thr Val Ile Asp Gln Thr Val Ile 
    690                 695                 700                 


Thr Asn Ala Glu Gly Ile Ala Asp Ser Thr Leu Thr Asn Thr Thr Ala 
705                 710                 715                 720 


Gly Val Ser Ala Val Thr Ala Thr Leu Gly Ser Gln Ser Gln Gln Val 
                725                 730                 735     


Asp Thr Thr Phe Lys Pro Gly Ser Thr Ala Ala Ile Ser Leu Val Lys 
            740                 745                 750         


Leu Ala Asp Arg Ala Val Ala Asp Gly Ile Asp Gln Asn Glu Ile Gln 
        755                 760                 765             


Val Val Leu Arg Asp Gly Thr Gly Asn Ala Val Pro Asn Val Pro Met 
    770                 775                 780                 


Ser Ile Gln Ala Asp Asn Gly Ala Ile Val Val Ala Ser Thr Pro Asn 
785                 790                 795                 800 


Thr Gly Val Asp Gly Thr Ile Asn Ala Thr Phe Thr Asn Leu Arg Ala 
                805                 810                 815     


Gly Glu Ser Val Val Ser Val Thr Ser Pro Ala Leu Val Gly Met Thr 
            820                 825                 830         


Met Thr Met Thr Phe Ser Ala Asp Gln Arg Thr Ala Val Val Ser Thr 
        835                 840                 845             


Leu Ala Ala Ile Asp Asn Asn Ala Lys Ala Asp Gly Thr Asp Thr Asn 
    850                 855                 860                 


Val Val Arg Ala Trp Val Val Asp Ala Asn Gly Asn Ser Val Pro Gly 
865                 870                 875                 880 


Val Ser Val Thr Phe Asp Ala Gly Asn Gly Ala Val Leu Ala Gln Asn 
                885                 890                 895     


Pro Val Val Thr Asp Arg Asn Gly Tyr Ala Glu Asn Thr Leu Thr Asn 
            900                 905                 910         


Leu Ala Ile Gly Thr Thr Thr Val Lys Ala Thr Thr Val Thr Asp Pro 
        915                 920                 925             


Val Gly Gln Thr Val Asn Thr His Phe Val Ala Gly Ala Val Asp Thr 
    930                 935                 940                 


Ile Thr Leu Thr Val Leu Val Asn Gly Ala Val Ala Asn Gly Val Asn 
945                 950                 955                 960 


Thr Asn Ser Val Gln Ala Val Val Ser Asp Ser Gly Gly Asn Pro Val 
                965                 970                 975     


Asn Gly Ala Ala Val Val Phe Ser Ser Ala Asn Ala Thr Ala Gln Ile 
            980                 985                 990         


Thr Thr Val Ile Gly Thr Thr Gly  Val Asp Gly Ile Ala  Thr Ala Thr 
        995                 1000                 1005             


Leu Thr  Asn Thr Val Ala Gly  Thr Ser Asn Val Val  Ala Thr Ile 
    1010                 1015                 1020             


Asp Thr  Val Asn Ala Asn Ile  Asp Thr Thr Phe Val  Ala Gly Ala 
    1025                 1030                 1035             


Val Ala  Thr Ile Thr Leu Thr  Thr Leu Val Asn Gly  Ala Val Ala 
    1040                 1045                 1050             


Asp Gly  Ala Asn Ser Asn Ser  Val Gln Ala Val Val  Ser Asp Ser 
    1055                 1060                 1065             


Gly Gly  Asn Pro Val Thr Gly  Ala Ala Val Val Phe  Ser Ser Ala 
    1070                 1075                 1080             


Asn Ala  Thr Ala Gln Ile Thr  Thr Val Ile Gly Thr  Thr Gly Val 
    1085                 1090                 1095             


Asp Gly  Ile Ala Thr Ala Thr  Leu Thr Asn Thr Val  Ala Gly Thr 
    1100                 1105                 1110             


Ser Asn  Val Val Ala Thr Ile  Gly Ser Ile Thr Asn  Asn Ile Asp 
    1115                 1120                 1125             


Thr Ala  Phe Val Ala Gly Ala  Val Ala Thr Ile Thr  Leu Thr Thr 
    1130                 1135                 1140             


Pro Val  Asn Gly Ala Val Ala  Asp Gly Ala Asn Ser  Asn Ser Val 
    1145                 1150                 1155             


Gln Ala  Val Val Thr Asp Ser  Gly Gly Asn Pro Val  Asn Gly Ala 
    1160                 1165                 1170             


Ala Val  Val Phe Ser Ser Ala  Asn Ala Thr Ala Gln  Ile Thr Thr 
    1175                 1180                 1185             


Val Ile  Gly Thr Thr Gly Ala  Asp Gly Ile Ala Thr  Ala Thr Leu 
    1190                 1195                 1200             


Thr Asn  Thr Val Ala Gly Thr  Ser Asn Val Val Ala  Thr Val Asp 
    1205                 1210                 1215             


Thr Val  Asn Ala Asn Ile Asp  Thr Thr Phe Val Ala  Gly Ala Val 
    1220                 1225                 1230             


Ala Thr  Ile Thr Leu Thr Thr  Pro Val Asn Gly Ala  Val Ala Asp 
    1235                 1240                 1245             


Gly Ala  Asp Ser Asn Ser Val  Gln Ala Val Val Ser  Asp Ser Gly 
    1250                 1255                 1260             


Gly Asn  Pro Val Ala Gly Ala  Ala Val Val Phe Ser  Ser Ala Asn 
    1265                 1270                 1275             


Ala Thr  Ala Gln Val Thr Thr  Val Ile Gly Thr Thr  Gly Ala Asp 
    1280                 1285                 1290             


Gly Ile  Ala Thr Ala Thr Leu  Thr Asn Thr Val Ala  Gly Thr Ser 
    1295                 1300                 1305             


Asn Val  Val Ala Thr Ile Gly  Ser Ile Thr Asn Asn  Ile Asp Thr 
    1310                 1315                 1320             


Ala Phe  Val Ala Gly Ala Val  Ala Thr Ile Thr Leu  Ser Val Pro 
    1325                 1330                 1335             


Val Asn  Asp Ala Thr Ala Asp  Gly Val Asp Thr Asn  Gln Val Asp 
    1340                 1345                 1350             


Ala Leu  Val Gln Asp Ala Asn  Gly Asn Ala Ile Thr  Gly Ala Ala 
    1355                 1360                 1365             


Val Val  Phe Ser Ser Thr Asn  Gly Ala Asp Ile Ile  Val Pro Thr 
    1370                 1375                 1380             


Met Asn  Thr Gly Val Asn Gly  Val Ala Ser Thr Leu  Leu Thr His 
    1385                 1390                 1395             


Thr Val  Ala Gly Thr Ser Asn  Val Val Ala Thr Val  Asp Thr Val 
    1400                 1405                 1410             


Asn Ala  Asn Ile Asp Thr Ala  Phe Val Pro Gly Ala  Val Ala Thr 
    1415                 1420                 1425             


Ile Thr  Leu Thr Thr Pro Val  Asn Gly Ala Val Ala  Asp Gly Ala 
    1430                 1435                 1440             


Asn Ser  Asn Ser Val Gln Ala  Val Val Ser Asp Ser  Glu Gly Asn 
    1445                 1450                 1455             


Ala Val  Ala Gly Ala Ala Val  Val Phe Ser Ser Ala  Asn Ala Thr 
    1460                 1465                 1470             


Ala Gln  Ile Thr Thr Val Ile  Gly Thr Thr Gly Ala  Asp Gly Ile 
    1475                 1480                 1485             


Ala Thr  Ala Thr Leu Thr Asn  Thr Val Ala Gly Thr  Ser Asn Val 
    1490                 1495                 1500             


Val Ala  Thr Ile Asp Thr Val  Asn Ala Asn Ile Asp  Thr Ala Phe 
    1505                 1510                 1515             


Val Pro  Gly Ala Val Ala Thr  Ile Thr Leu Ser Val  Leu Val Asn 
    1520                 1525                 1530             


Asp Ala  Thr Ala Asp Gly Ala  Asp Thr Asn Gln Val  Asp Ala Leu 
    1535                 1540                 1545             


Val Gln  Asp Ala Asn Gly Asn  Ala Ile Thr Gly Ala  Ala Val Val 
    1550                 1555                 1560             


Phe Ser  Ser Ala Asn Gly Ala  Asp Ile Ile Ala Pro  Thr Met Asn 
    1565                 1570                 1575             


Thr Gly  Val Asn Gly Val Ala  Ser Thr Leu Leu Thr  His Thr Gln 
    1580                 1585                 1590             


Ser Gly  Val Ser Asn Val Val  Ala Thr Ile Asp Thr  Val Asn Ala 
    1595                 1600                 1605             


Asn Ile  Asp Thr Thr Phe Val  Ala Gly Ala Val Ala  Ala Ile Thr 
    1610                 1615                 1620             


Leu Thr  Thr Pro Val Asp Gly  Ala Val Ala Asp Gly  Thr Asp Ser 
    1625                 1630                 1635             


Asn Ser  Val Gln Ala Val Val  Ser Asp Ser Glu Gly  Asn Ala Val 
    1640                 1645                 1650             


Ala Gly  Ala Ala Val Val Phe  Ser Ser Ala Asn Ala  Thr Ala Gln 
    1655                 1660                 1665             


Ile Thr  Thr Val Ile Gly Thr  Thr Gly Ala Asp Gly  Ile Ala Thr 
    1670                 1675                 1680             


Ala Thr  Leu Thr Asn Thr Val  Ala Gly Thr Ser Asn  Val Ala Ala 
    1685                 1690                 1695             


Thr Ile  Gly Ser Ile Thr Asp  Asn Ile Asp Thr Val  Phe Val Ala 
    1700                 1705                 1710             


Gly Ala  Val Ala Thr Ile Thr  Leu Ser Val Pro Val  Asn Asp Ala 
    1715                 1720                 1725             


Thr Ala  Asp Gly Ala Asp Thr  Asn Gln Val Asp Ala  Leu Val Gln 
    1730                 1735                 1740             


Asp Val  Asn Gly Asn Ala Ile  Thr Gly Ala Ala Val  Val Phe Ser 
    1745                 1750                 1755             


Ser Ala  Asn Gly Ala Thr Ile  Leu Ser Ser Thr Val  Asn Thr Gly 
    1760                 1765                 1770             


Ala Asp  Gly Ile Ala Ser Thr  Thr Leu Thr His Thr  Gln Ser Gly 
    1775                 1780                 1785             


Val Ser  Asn Val Val Ala Thr  Ile Asp Thr Val Asn  Ala Asn Ile 
    1790                 1795                 1800             


Asp Thr  Thr Phe Val Ala Gly  Ala Val Ala Thr Ile  Thr Leu Ser 
    1805                 1810                 1815             


Val Leu  Val Asn Asp Ala Thr  Ala Asp Gly Ala Asp  Thr Asn Gln 
    1820                 1825                 1830             


Val Asp  Ala Leu Val Gln Asp  Ala Asn Gly Asn Ala  Ile Thr Gly 
    1835                 1840                 1845             


Ala Ala  Val Val Phe Ser Ser  Ala Asn Gly Ala Thr  Ile Ile Val 
    1850                 1855                 1860             


Pro Thr  Met Asn Thr Gly Ala  Asn Gly Val Ala Ser  Thr Leu Leu 
    1865                 1870                 1875             


Thr His  Thr Val Ala Gly Thr  Ser Asn Val Val Ala  Thr Ile Gly 
    1880                 1885                 1890             


Ser Ile  Thr Asn Asn Ile Asp  Thr Ala Phe Val Ala  Gly Ala Val 
    1895                 1900                 1905             


Ala Thr  Ile Thr Leu Thr Thr  Pro Val Asn Gly Ala  Val Ala Asp 
    1910                 1915                 1920             


Gly Ala  Asn Ser Asn Ser Val  Gln Ala Val Val Ser  Asp Ser Glu 
    1925                 1930                 1935             


Gly Asn  Ala Val Ala Gly Ala  Ala Val Val Phe Ser  Ser Ala Asn 
    1940                 1945                 1950             


Ala Thr  Ala Gln Ile Thr Thr  Val Ile Gly Thr Thr  Gly Ala Asp 
    1955                 1960                 1965             


Gly Ile  Ala Thr Ala Thr Leu  Thr Asn Thr Val Ala  Gly Thr Ser 
    1970                 1975                 1980             


Asn Val  Val Ala Thr Ile Gly  Ser Ile Thr Asp Asn  Ile Asp Thr 
    1985                 1990                 1995             


Val Phe  Val Ala Gly Ala Val  Ala Thr Ile Thr Leu  Thr Thr Pro 
    2000                 2005                 2010             


Val Asn  Gly Ala Val Ala Asp  Gly Ala Asn Ser Asn  Ser Val Gln 
    2015                 2020                 2025             


Ala Val  Val Ser Asp Ser Glu  Gly Asn Pro Val Thr  Gly Ala Thr 
    2030                 2035                 2040             


Val Val  Phe Ser Ser Ser Asn  Ala Thr Ala Gln Ile  Thr Thr Val 
    2045                 2050                 2055             


Ile Gly  Thr Thr Gly Ala Asp  Gly Ile Ala Thr Ala  Thr Leu Thr 
    2060                 2065                 2070             


Asn Thr  Val Ala Gly Thr Ser  Asn Val Val Ala Thr  Ile Asp Thr 
    2075                 2080                 2085             


Val Asn  Ala Asn Ile Asp Thr  Thr Phe Val Pro Gly  Ala Val Ala 
    2090                 2095                 2100             


Thr Ile  Thr Leu Thr Thr Pro  Val Asp Gly Ala Val  Ala Asp Gly 
    2105                 2110                 2115             


Ala Asn  Ser Asn Ser Val Gln  Ala Val Val Thr Asp  Ser Gly Gly 
    2120                 2125                 2130             


Asn Pro  Val Thr Gly Ala Ala  Val Val Phe Ser Ser  Ala Asn Ala 
    2135                 2140                 2145             


Thr Ala  Gln Ile Thr Thr Val  Ile Gly Thr Thr Gly  Ala Asp Gly 
    2150                 2155                 2160             


Ile Ala  Thr Ala Thr Leu Thr  Asn Thr Val Ala Gly  Thr Ser Asn 
    2165                 2170                 2175             


Val Val  Ala Thr Val Asp Thr  Val Asn Ala Asn Ile  Asp Thr Thr 
    2180                 2185                 2190             


Phe Val  Ala Gly Ala Val Ala  Thr Ile Thr Leu Thr  Thr Pro Val 
    2195                 2200                 2205             


Asn Gly  Ala Val Ala Asn Gly  Ala Asp Ser Asn Ser  Val Gln Ala 
    2210                 2215                 2220             


Val Val  Ser Asp Ser Glu Gly  Asn Ala Val Ala Gly  Ala Ala Val 
    2225                 2230                 2235             


Val Phe  Ser Ser Ala Asn Ala  Thr Ala Gln Ile Thr  Thr Val Ile 
    2240                 2245                 2250             


Gly Thr  Thr Gly Ala Asp Gly  Ile Ala Thr Ala Thr  Leu Ile Asn 
    2255                 2260                 2265             


Thr Val  Ala Gly Thr Ser Asn  Val Val Ala Thr Ile  Asp Thr Val 
    2270                 2275                 2280             


Asn Ala  Asn Ile Asp Thr Thr  Phe Val Ala Gly Ala  Val Ala Thr 
    2285                 2290                 2295             


Ile Thr  Leu Thr Thr Pro Val  Asp Gly Ala Val Ala  Asn Gly Ala 
    2300                 2305                 2310             


Asp Ser  Asn Ser Val Gln Ala  Val Val Ser Asp Ser  Glu Gly Asn 
    2315                 2320                 2325             


Ala Val  Ala Gly Ala Ala Val  Val Phe Ser Ser Ala  Asn Ala Thr 
    2330                 2335                 2340             


Ala Gln  Ile Thr Thr Val Ile  Gly Thr Thr Gly Ala  Asp Gly Ile 
    2345                 2350                 2355             


Ala Thr  Ala Thr Leu Thr Asn  Thr Val Ala Gly Thr  Ser Asn Val 
    2360                 2365                 2370             


Val Ala  Thr Ile Gly Ser Ile  Thr Asn Asn Ile Asp  Thr Ala Phe 
    2375                 2380                 2385             


Val Ala  Gly Ala Val Ala Thr  Ile Thr Leu Thr Thr  Pro Val Asn 
    2390                 2395                 2400             


Gly Ala  Val Ala Asp Gly Ala  Asn Ser Asn Ser Val  Gln Ala Val 
    2405                 2410                 2415             


Val Thr  Asp Ser Gly Gly Asn  Pro Val Asn Gly Ala  Ala Val Val 
    2420                 2425                 2430             


Phe Ser  Ser Ala Asn Ala Thr  Ala Gln Ile Thr Thr  Val Ile Gly 
    2435                 2440                 2445             


Thr Thr  Gly Ala Asp Gly Ile  Ala Thr Ala Thr Leu  Thr Asn Thr 
    2450                 2455                 2460             


Val Ala  Gly Thr Ser Asn Val  Val Ala Thr Val Asp  Thr Val Asn 
    2465                 2470                 2475             


Ala Asn  Ile Asp Thr Thr Phe  Val Ala Gly Ala Val  Ala Thr Ile 
    2480                 2485                 2490             


Thr Leu  Thr Thr Pro Val Asn  Gly Ala Val Ala Asp  Gly Ala Asp 
    2495                 2500                 2505             


Ser Asn  Ser Val Gln Ala Val  Val Ser Asp Ser Gly  Gly Asn Pro 
    2510                 2515                 2520             


Val Ala  Gly Ala Ala Val Val  Phe Ser Ser Ala Asn  Ala Thr Ala 
    2525                 2530                 2535             


Gln Val  Thr Thr Val Ile Gly  Thr Thr Gly Ala Asp  Gly Ile Ala 
    2540                 2545                 2550             


Thr Ala  Thr Leu Thr Asn Thr  Val Ala Gly Thr Ser  Asn Val Val 
    2555                 2560                 2565             


Ala Thr  Ile Gly Ser Ile Thr  Asn Asn Ile Asp Thr  Ala Phe Val 
    2570                 2575                 2580             


Ala Gly  Ala Val Ala Thr Ile  Thr Leu Thr Thr Pro  Val Asn Gly 
    2585                 2590                 2595             


Ala Val  Ala Asp Gly Ala Asp  Ser Asn Ser Val Gln  Ala Val Val 
    2600                 2605                 2610             


Ser Asp  Ser Glu Gly Asn Ala  Val Thr Gly Ala Ala  Val Val Phe 
    2615                 2620                 2625             


Ser Ser  Ala Asn Ala Thr Ala  Gln Ile Thr Thr Val  Ile Gly Thr 
    2630                 2635                 2640             


Thr Gly  Ala Asp Gly Ile Ala  Thr Ala Thr Leu Thr  Asn Thr Val 
    2645                 2650                 2655             


Ala Gly  Thr Ser Asn Val Val  Ala Thr Ile Gly Gly  Ile Thr Asn 
    2660                 2665                 2670             


Asn Ile  Asp Thr Ala Phe Val  Ala Gly Ala Val Ala  Thr Ile Thr 
    2675                 2680                 2685             


Leu Thr  Thr Pro Val Asn Gly  Ala Val Ala Asp Gly  Thr Asp Ser 
    2690                 2695                 2700             


Asn Ser  Val Gln Ala Val Val  Ser Asp Ser Glu Gly  Asn Ala Val 
    2705                 2710                 2715             


Ala Gly  Ala Ala Val Val Phe  Ser Ser Ala Asn Ala  Thr Ala Gln 
    2720                 2725                 2730             


Ile Thr  Thr Val Ile Gly Thr  Thr Gly Ala Asp Gly  Ile Ala Thr 
    2735                 2740                 2745             


Ala Thr  Leu Thr Asn Thr Val  Ala Gly Thr Ser Asn  Val Val Ala 
    2750                 2755                 2760             


Thr Ile  Gly Ser Ile Thr Asn  Asn Ile Asp Thr Ala  Phe Val Ala 
    2765                 2770                 2775             


Gly Ala  Val Ala Thr Ile Thr  Leu Thr Thr Leu Val  Asn Gly Ala 
    2780                 2785                 2790             


Val Ala  Asn Gly Ala Asp Ser  Asn Ser Val Gln Ala  Val Val Ser 
    2795                 2800                 2805             


Asp Ser  Gly Gly Asn Val Val  Ala Gly Ala Thr Val  Val Phe Ser 
    2810                 2815                 2820             


Ser Thr  Asn Ala Thr Ala Gln  Val Thr Thr Val Ile  Gly Thr Thr 
    2825                 2830                 2835             


Gly Ala  Asp Gly Ile Ala Thr  Ala Thr Leu Thr Asn  Thr Val Ala 
    2840                 2845                 2850             


Gly Thr  Ser Asn Val Val Ala  Thr Ile Asp Thr Val  Asn Ala Asn 
    2855                 2860                 2865             


Ile Asp  Thr Thr Phe Val Ala  Gly Ala Val Ala Thr  Ile Thr Leu 
    2870                 2875                 2880             


Ser Val  Leu Val Asn Asp Ala  Thr Ala Asp Gly Ala  Asp Thr Asn 
    2885                 2890                 2895             


Gln Val  Asp Ala Leu Val Gln  Asp Ala Asn Gly Asn  Ala Ile Thr 
    2900                 2905                 2910             


Gly Ala  Ala Val Val Phe Ser  Ser Ala Asn Gly Ala  Thr Ile Leu 
    2915                 2920                 2925             


Ser Ser  Thr Met Asn Thr Gly  Val Asn Gly Val Ala  Ser Thr Leu 
    2930                 2935                 2940             


Leu Thr  His Thr Val Ala Gly  Thr Ser Asn Val Val  Ala Thr Ile 
    2945                 2950                 2955             


Asp Thr  Val Asn Ala Asn Ile  Asp Thr Ala Phe Val  Ala Gly Ala 
    2960                 2965                 2970             


Val Ala  Thr Ile Thr Leu Thr  Thr Pro Val Asn Gly  Ala Val Ala 
    2975                 2980                 2985             


Asn Gly  Ala Asp Ser Asn Ser  Val Gln Ala Val Val  Ser Asp Ser 
    2990                 2995                 3000             


Glu Gly  Asn Ala Val Ala Gly  Ala Ala Val Val Phe  Ser Ser Ala 
    3005                 3010                 3015             


Asn Ala  Thr Ala Gln Ile Thr  Thr Val Ile Gly Thr  Thr Gly Val 
    3020                 3025                 3030             


Asp Gly  Ile Ala Thr Ala Thr  Leu Thr Asn Thr Val  Ala Gly Thr 
    3035                 3040                 3045             


Ser Asn  Val Val Ala Thr Val  Asp Thr Val Asn Ala  Asn Ile Asp 
    3050                 3055                 3060             


Thr Ala  Phe Val Ala Gly Ala  Val Ala Thr Ile Thr  Leu Thr Thr 
    3065                 3070                 3075             


Pro Val  Asn Gly Ala Val Ala  Asn Gly Ala Asp Ser  Asn Ser Val 
    3080                 3085                 3090             


Gln Ala  Val Val Ser Asp Ser  Gly Gly Asn Val Val  Ala Gly Ala 
    3095                 3100                 3105             


Thr Val  Val Phe Ser Ser Thr  Asn Thr Thr Ala Gln  Val Thr Thr 
    3110                 3115                 3120             


Val Ile  Gly Thr Thr Gly Ala  Asp Gly Ile Ala Thr  Ala Thr Leu 
    3125                 3130                 3135             


Thr Asn  Thr Val Ala Gly Thr  Ser Asn Val Val Ala  Thr Val Asp 
    3140                 3145                 3150             


Thr Val  Asn Ala Asn Ile Asp  Thr Thr Phe Val Ala  Gly Ala Val 
    3155                 3160                 3165             


Ala Thr  Ile Thr Leu Ser Val  Leu Val Asn Asp Ala  Thr Ala Asp 
    3170                 3175                 3180             


Gly Ala  Asp Thr Asn Gln Val  Asp Ala Leu Val Gln  Asp Ala Asn 
    3185                 3190                 3195             


Gly Asn  Ala Ile Thr Gly Ala  Ala Val Val Phe Ser  Ser Ala Asn 
    3200                 3205                 3210             


Gly Ala  Asp Ile Ile Ala Pro  Thr Met Asn Thr Gly  Val Asn Gly 
    3215                 3220                 3225             


Val Ala  Ser Thr Leu Leu Thr  His Thr Met Ala Gly  Thr Ser Asn 
    3230                 3235                 3240             


Val Ile  Ala Thr Ile Asp Thr  Val Asn Ala Asn Ile  Asp Thr Thr 
    3245                 3250                 3255             


Phe Val  Ala Gly Ala Val Ala  Thr Ile Thr Leu Ser  Val Pro Val 
    3260                 3265                 3270             


Asn Asp  Ala Thr Ala Asp Gly  Ala Asp Thr Asn Gln  Val Asp Ala 
    3275                 3280                 3285             


Leu Val  Gln Asp Ala Asn Gly  Asn Ala Ile Thr Gly  Ala Ala Val 
    3290                 3295                 3300             


Val Phe  Ser Ser Ala Asn Gly  Ala Thr Ile Leu Ser  Ser Thr Met 
    3305                 3310                 3315             


Asn Thr  Gly Val Asn Gly Val  Ala Ser Thr Leu Leu  Thr His Thr 
    3320                 3325                 3330             


Gln Ser  Gly Val Ser Asn Val  Val Ala Thr Ile Asp  Thr Val Asn 
    3335                 3340                 3345             


Ala Asn  Ile Asp Thr Ala Phe  Val Ala Gly Ala Val  Ala Thr Ile 
    3350                 3355                 3360             


Thr Leu  Thr Thr Pro Val Asn  Gly Ala Val Ala Asp  Gly Ala Asn 
    3365                 3370                 3375             


Ser Asn  Ser Val Gln Ala Val  Val Thr Asp Ser Gly  Gly Asn Pro 
    3380                 3385                 3390             


Val Asn  Gly Ala Ala Val Val  Phe Ser Ser Ala Asn  Ala Thr Ala 
    3395                 3400                 3405             


Gln Ile  Thr Thr Val Ile Gly  Thr Thr Gly Ala Asp  Gly Ile Ala 
    3410                 3415                 3420             


Thr Ala  Thr Leu Thr Asn Thr  Val Ala Gly Thr Ser  Asn Val Ala 
    3425                 3430                 3435             


Ala Thr  Ile Asp Thr Val Asn  Ala Asn Ile Asp Thr  Thr Phe Val 
    3440                 3445                 3450             


Ala Gly  Ala Val Ala Thr Ile  Thr Leu Thr Thr Pro  Val Asn Gly 
    3455                 3460                 3465             


Ala Val  Ala Asp Gly Ala Asn  Ser Asn Ser Val Gln  Ala Val Val 
    3470                 3475                 3480             


Ser Asp  Ser Glu Gly Asn Pro  Val Asn Gly Ala Thr  Val Val Phe 
    3485                 3490                 3495             


Ser Ser  Ile Asn Ala Thr Ala  Gln Ile Thr Thr Val  Ile Gly Thr 
    3500                 3505                 3510             


Thr Gly  Val Asp Gly Ile Ala  Thr Ala Thr Leu Thr  Asn Thr Val 
    3515                 3520                 3525             


Ala Gly  Thr Ser Asn Val Val  Ala Thr Ile Asp Thr  Val Asn Ala 
    3530                 3535                 3540             


Asn Ile  Asp Thr Thr Phe Val  Ala Gly Ala Val Ala  Thr Ile Thr 
    3545                 3550                 3555             


Leu Thr  Thr Leu Val Asn Gly  Ala Val Ala Asp Gly  Ala Asn Ser 
    3560                 3565                 3570             


Asn Ser  Val Gln Ala Val Val  Ser Asp Ser Gly Gly  Asn Pro Val 
    3575                 3580                 3585             


Thr Gly  Ala Ala Val Val Phe  Ser Ser Ala Asn Ala  Thr Ala Gln 
    3590                 3595                 3600             


Ile Thr  Thr Val Ile Gly Thr  Thr Gly Val Asp Gly  Ile Ala Thr 
    3605                 3610                 3615             


Ala Thr  Leu Thr Asn Thr Val  Ala Gly Thr Ser Asn  Val Val Ala 
    3620                 3625                 3630             


Thr Ile  Gly Ser Ile Thr Asn  Asn Ile Asp Thr Ala  Phe Val Ala 
    3635                 3640                 3645             


Gly Ala  Val Ala Thr Ile Thr  Leu Thr Thr Pro Val  Asn Gly Ala 
    3650                 3655                 3660             


Val Ala  Asp Gly Ala Asn Ser  Asn Ser Val Gln Ala  Val Val Thr 
    3665                 3670                 3675             


Asp Ser  Gly Gly Asn Pro Val  Asn Gly Ala Ala Val  Val Phe Ser 
    3680                 3685                 3690             


Ser Ala  Asn Ala Thr Ala Gln  Ile Thr Thr Val Ile  Gly Thr Thr 
    3695                 3700                 3705             


Gly Ala  Asp Gly Ile Ala Thr  Ala Thr Leu Thr Asn  Thr Val Ala 
    3710                 3715                 3720             


Gly Thr  Ser Asn Val Ile Ala  Thr Ile Asp Thr Val  Asn Ala Asn 
    3725                 3730                 3735             


Ile Asp  Thr Thr Phe Val Ala  Gly Ala Val Ala Thr  Ile Thr Leu 
    3740                 3745                 3750             


Thr Thr  Pro Val Asn Gly Ala  Val Ala Asp Gly Ala  Asp Ser Asn 
    3755                 3760                 3765             


Ser Val  Gln Ala Val Val Ser  Asp Ser Glu Gly Asn  Ala Val Thr 
    3770                 3775                 3780             


Gly Ala  Ala Val Val Phe Ser  Ser Ala Asn Ala Thr  Ala Gln Ile 
    3785                 3790                 3795             


Thr Thr  Val Ile Gly Thr Thr  Gly Ala Asp Gly Ile  Ala Thr Ala 
    3800                 3805                 3810             


Thr Leu  Thr Asn Thr Val Ala  Gly Thr Ser Asn Val  Val Ala Thr 
    3815                 3820                 3825             


Ile Asp  Thr Val Asn Ala Asn  Ile Asp Thr Ala Phe  Val Ala Gly 
    3830                 3835                 3840             


Glu Leu  Glu Asn Ile Val Val  Ser Ile Ile Asn Asn  Asn Ala Leu 
    3845                 3850                 3855             


Ala Asn  Gly Ala Asp Thr Asn  Ile Val Glu Ala Phe  Val Thr Asp 
    3860                 3865                 3870             


Arg Phe  Gly Asn Gly Val Ala  Asn Gln Ser Leu Met  Phe Gly Thr 
    3875                 3880                 3885             


Asn Gly  Ala Ser Ile Val Gly  Ser Ser Thr Val Thr  Thr Asn Ile 
    3890                 3895                 3900             


Asp Gly  Arg Val Arg Val Ser  Ala Thr His Thr Val  Ala Gly Ser 
    3905                 3910                 3915             


Ser Asn  Thr Val Phe Ala Ile  Ser Gly Ala His Gln  Gly Tyr Thr 
    3920                 3925                 3930             


Arg Val  Thr Phe Val Ala Asp  Ala Ser Thr Ala Gln  Leu Lys Leu 
    3935                 3940                 3945             


Thr Ser  Phe Leu Asp Asn Gln  Leu Ala Asn Gly Lys  Ala Gly Asn 
    3950                 3955                 3960             


Ile Ala  Gln Ala Leu Val Thr  Asp Ala Tyr Asp Asn  Pro Leu Ala 
    3965                 3970                 3975             


Asn Gln  Ser Val Ser Phe Ala  Leu Asp Asn Gly Ala  Val Ile Glu 
    3980                 3985                 3990             


Ser Arg  Gly Asp Ala Ser Ser  Ala Ser Gly Ile Val  Leu Met Arg 
    3995                 4000                 4005             


Phe Asn  Asn Thr Leu Ala Gly  Met Thr Thr Val Thr  Ala Thr Leu 
    4010                 4015                 4020             


Asp Ser  Thr Gly Gln Thr Glu  Thr Leu Glu Met His  Phe Val Ala 
    4025                 4030                 4035             


Gly Lys  Ala Ala Ser Ile Glu  Leu Thr Met Thr Lys  Asp Asn Ala 
    4040                 4045                 4050             


Val Ala  Asn Asn Ile Asp Thr  Asn Glu Val Gln Val  Leu Val Thr 
    4055                 4060                 4065             


Asp Ala  Asp Gly Asn Ala Ile  Asn Gly Ala Val Val  Asn Leu Thr 
    4070                 4075                 4080             


Ser Asn  Ser Gly Met Asn Ile  Thr Pro Asn Ser Val  Thr Thr Gly 
    4085                 4090                 4095             


Ser Asp  Gly Thr Ala Thr Ala  Thr Leu Thr His Thr  Leu Ala Gly 
    4100                 4105                 4110             


Ser Leu  Pro Ile Asn Ala Arg  Ile Asp Gln Val Ser  Lys Thr Ile 
    4115                 4120                 4125             


Asn Ala  Thr Phe Ile Ala Asp  Val Ser Thr Ala Gln  Ile Ile Ala 
    4130                 4135                 4140             


Ser Asp  Met Phe Ile Ile Val  Asn Asp Gln Val Ala  Asn Gly Gln 
    4145                 4150                 4155             


Ala Val  Asn Ala Val Gln Ala  Arg Val Thr Asp Ser  Tyr Gly Asn 
    4160                 4165                 4170             


Pro Ile  Gln Gly Gln Leu Val  Glu Phe Val Leu Ser  Asn Thr Gly 
    4175                 4180                 4185             


Thr Ile  Gln Tyr Lys Leu Glu  Glu Thr Ser Val Glu  Gly Gly Val 
    4190                 4195                 4200             


Met Val  Thr Phe Thr Asn Thr  Leu Ala Gly Ile Thr  Asn Val Thr 
    4205                 4210                 4215             


Ala Thr  Val Val Ser Ser Arg  Ser Ser Gln Asn Val  Asp Thr Thr 
    4220                 4225                 4230             


Phe Ile  Ala Asp Val Thr Thr  Ala His Ile Ala Glu  Ser Asp Leu 
    4235                 4240                 4245             


Met Val  Ile Val Asp Asn Ala  Val Ala Asn Asn Ser  Glu Lys Asn 
    4250                 4255                 4260             


Glu Val  His Ala Arg Val Thr  Asp Ala Lys Gly Asn  Val Leu Ser 
    4265                 4270                 4275             


Gly Gln  Thr Val Ile Phe Thr  Ser Gly Asn Gly Ala  Ala Ile Thr 
    4280                 4285                 4290             


Thr Val  Asn Gly Ile Ser Asp  Gly Asp Gly Leu Thr  Lys Ala Thr 
    4295                 4300                 4305             


Leu Thr  His Thr Leu Ala Gly  Thr Ser Val Val Thr  Ala Arg Val 
    4310                 4315                 4320             


Gly Asn  Gln Val Gln Ser Lys  Asp Thr Thr Phe Ile  Ala Asp Arg 
    4325                 4330                 4335             


Thr Thr  Ala Thr Ile Arg Ala  Ser Asp Leu Thr Ile  Thr Arg Ser 
    4340                 4345                 4350             


Asn Ala  Leu Ala Asp Gly Val  Ala Thr Asn Ala Ala  Arg Val Ile 
    4355                 4360                 4365             


Val Thr  Asp Ala Tyr Gly Asn  Pro Val Pro Ser Met  Leu Val Ser 
    4370                 4375                 4380             


Tyr Thr  Ser Glu Asn Gly Ala  Thr Leu Thr Pro Thr  Leu Gly Ser 
    4385                 4390                 4395             


Thr Asp  Ser Ser Gly Met Leu  Ser Thr Thr Phe Thr  His Thr Ile 
    4400                 4405                 4410             


Ala Gly  Ile Ser Lys Val Thr  Ala Thr Ile Val Thr  Met Gly Ile 
    4415                 4420                 4425             


Ser Gln  Ala Lys Asp Ala Val  Phe Ile Ala Asp Arg  Thr Thr Ala 
    4430                 4435                 4440             


His Val  Ser Ala Leu Thr Val  Glu Lys Asn Asp Ser  Leu Ala Asn 
    4445                 4450                 4455             


Asn Ser  Asp Arg Asn Ile Val  Gln Ala His Ile Gln  Asp Ala His 
    4460                 4465                 4470             


Gly Asn  Val Ile Thr Gly Met  Asn Val Asn Phe Ser  Ala Thr Glu 
    4475                 4480                 4485             


Asn Val  Thr Leu Ala Ala Asn  Met Val Thr Thr Asn  Ala Gln Gly 
    4490                 4495                 4500             


Tyr Ala  Glu Asn Thr Leu Arg  His Asn Ala Pro Val  Thr Ser Ala 
    4505                 4510                 4515             


Val Thr  Ala Thr Val Ala Thr  Asp Leu Val Gly Leu  Thr Glu Asp 
    4520                 4525                 4530             


Val Arg  Phe Val Ala Gly Ala  Gly Ala Arg Ile Glu  Leu Phe Arg 
    4535                 4540                 4545             


Leu Asn  Asp Gly Ala Val Ala  Asp Gly Ile Gln Thr  Asn Arg Val 
    4550                 4555                 4560             


Glu Ala  Arg Val Tyr Asp Val  Ser Asp Asn Leu Val  Pro Asn Ser 
    4565                 4570                 4575             


Asn Val  Val Phe Ser Ala Asp  Asn Gly Gly Gln Leu  Val Gln Asn 
    4580                 4585                 4590             


Asp Val  Gln Thr Asp Ala Leu  Gly Ser Ala Tyr Val  Thr Val Ser 
    4595                 4600                 4605             


Asn Ile  Asn Thr Gly Val Thr  Lys Val Ser Val Thr  Ala Asp Gly 
    4610                 4615                 4620             


Val Ser  Ala Ser Thr Thr Thr  Thr Phe Ile Ala Asp  Lys Asp Thr 
    4625                 4630                 4635             


Val Thr  Leu Arg Ala Asp Leu  Phe Leu Ile Thr His  Asp Asn Ala 
    4640                 4645                 4650             


Val Ala  Asn Gly Val Thr Glu  Asn Arg Val Leu Leu  Gln Leu Leu 
    4655                 4660                 4665             


Asp Ala  Asn Asp Asn Lys Val  Ser Gly Val Glu Val  Asn Phe Thr 
    4670                 4675                 4680             


Ala Thr  Asn Gly Ala Ser Ile  Asn Ala Ser Ala Ile  Thr Asp Thr 
    4685                 4690                 4695             


Asn Gly  Leu Ala Ile Gly Val  Leu Thr Asn Thr Leu  Ser Gly Pro 
    4700                 4705                 4710             


Ser Asp  Val Thr Val Thr Leu  Val Thr Pro Gly Gly  Thr Glu Ser 
    4715                 4720                 4725             


Leu Thr  Val Thr Pro Gln Phe  Ile Ala Asp Ile Asn  Thr Ala Arg 
    4730                 4735                 4740             


Ile Ala  Asn Gly Asp Phe Val  Ile Ile Asp Asp Gly  Ala Val Ala 
    4745                 4750                 4755             


Asn Ser  Val Asp Ala Asn Glu  Val Arg Ala Arg Val  Thr Asp Asn 
    4760                 4765                 4770             


Gln Gly  Asn Ala Ile Ala Gly  Tyr Ser Val Thr Phe  Ala Ser Gln 
    4775                 4780                 4785             


Asn Gly  Ala Thr Ile Thr Thr  Ser Gly Ile Thr Gly  Val Asp Gly 
    4790                 4795                 4800             


Trp Ala  Ser Ala Lys Leu Thr  His Thr Lys Ala Gly  Glu Ser Gly 
    4805                 4810                 4815             


Ile Leu  Ala Arg Ile Ser Arg  Pro Gly Ser Met Val  Gln Val Leu 
    4820                 4825                 4830             


Thr Pro  Tyr Phe Ile Ala Asp  Val Ser Thr Ala Thr  Leu Gln Leu 
    4835                 4840                 4845             


Phe Asn  Phe Asn Pro Ile Pro  Ile Ile Ala Asp Gly  Val Met Gln 
    4850                 4855                 4860             


Phe Phe  Val Leu Gly Arg Val  Phe Asp Ala Asn Gln  Asn Pro Val 
    4865                 4870                 4875             


Gly Gly  Gln Gln Val Ala Phe  Ser Ala Thr Asn Glu  Val Thr Leu 
    4880                 4885                 4890             


Thr Glu  Ser Asn Gly Ser Ile  Ser Thr Pro Glu Gly  Ser Val Leu 
    4895                 4900                 4905             


Leu Ser  Val Thr Ser Thr Gln  Ala Gly Val His Pro  Ile Thr Gly 
    4910                 4915                 4920             


Thr Leu  Val Ser Asn Asn Tyr  Thr Asp Thr Phe Gly  Ala Thr Phe 
    4925                 4930                 4935             


Ile Ala  Asn Lys Asn Thr Ala  Gln Leu Ser Thr Leu  Met Val Val 
    4940                 4945                 4950             


Asp Asn  Asn Ala Leu Ala Asp  Gly Val Thr Arg Asn  Gln Val Arg 
    4955                 4960                 4965             


Ala His  Val Val Asp Ser Thr  Gly Asn Ser Val Ala  Asp Ile Ala 
    4970                 4975                 4980             


Val Thr  Phe Thr Ala Asn His  Gly Ala Gln Leu Ser  His Val Thr 
    4985                 4990                 4995             


Val Leu  Thr Asp Asp Asn Gly  Asp Ala Val Asn Thr  Leu Thr Asn 
    5000                 5005                 5010             


Ser Leu  Val Gly Val Thr Val  Val Thr Ala Lys Leu  Gly Thr Ala 
    5015                 5020                 5025             


Gly Thr  Pro Leu Thr Val Asp  Thr Val Phe Thr Ala  Gly Pro Leu 
    5030                 5035                 5040             


Ala Thr  Leu Thr Leu Val Thr  Met Val Asp Asn Ala  Phe Ala Asp 
    5045                 5050                 5055             


Asn Ser  Ala Thr Asn Thr Val  Gln Ala Thr Leu Lys  Asp Ala Thr 
    5060                 5065                 5070             


Gly Asn  Pro Ile Val Gly Glu  Val Val Ala Phe Ala  Ala Ser Asn 
    5075                 5080                 5085             


Gly Ala  Thr Ile Thr Ala Thr  Asp Gly Gly Val Ser  Asn Ala Asn 
    5090                 5095                 5100             


Gly Ile  Val Leu Ala Thr Leu  Thr Asn Gly Ala Ala  Gly Val Ser 
    5105                 5110                 5115             


Thr Val  Thr Ala Thr Ile Glu  Thr Leu Thr Ala Thr  Thr Glu Thr 
    5120                 5125                 5130             


Thr Phe  Ile Ala Met Lys Asn  Leu Asp Val Thr Val  Gly Asp Thr 
    5135                 5140                 5145             


Thr Phe  Asp Gly Asp Ala Gly  Phe Pro Thr Thr Gly  Phe Val Gly 
    5150                 5155                 5160             


Ala Ala  Phe Lys Val Asn Ser  Gly Gly Asp Asn Ser  Leu Tyr Asp 
    5165                 5170                 5175             


Trp Ser  Ser Ser Ala Pro Ala  Leu Val Ser Val Ser  Gly Glu Gly 
    5180                 5185                 5190             


Val Val  Thr Phe Asn Ala Val  Phe Pro Thr Gly Thr  Pro Ala Ile 
    5195                 5200                 5205             


Thr Ile  Ser Ala Thr Pro Lys  Gly Gly Gly Ser Pro  Leu Ser Tyr 
    5210                 5215                 5220             


Ser Phe  Arg Val Asn Gln Trp  Phe Ile Asn Asn Asn  Gly Val Ala 
    5225                 5230                 5235             


Leu Asn  Arg Ala Asp Ala Ala  Thr Tyr Cys Ala Asn  Ala Gly Tyr 
    5240                 5245                 5250             


Thr Thr  Val Ser Ser Ser Gln  Val Thr Asn Ala Ile  Val Trp Gly 
    5255                 5260                 5265             


Met Gly  Thr Arg Ala Met Gly  Asn Leu Trp Ser Glu  Trp Gly Asp 
    5270                 5275                 5280             


Phe Asn  Asn Tyr Asn Val Pro  Gly Trp Glu Pro Ala  Glu Phe Phe 
    5285                 5290                 5295             


Trp Leu  Ser Asp Asn Tyr Asn  Ala Thr Asp Gly Leu  Ala Ala Ser 
    5300                 5305                 5310             


Leu Ser  His Gly Val Leu Thr  Thr Met Gly Asp Pro  Met Ala Met 
    5315                 5320                 5325             


Ile His  Val Met Cys Thr Arg  Pro Ile 
    5330                 5335         


<210>  5
<211>  1920
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  InvD YPK_1315
<222>  (1)..(1920)

<400>  5

Met Ile Lys Tyr Phe Ser Phe Phe Lys Lys Pro Glu Pro Ile Val Gly 
1               5                   10                  15      


Ile Leu Pro Asn Arg Gln Ser His His Ile Leu Pro Thr His Ile Arg 
            20                  25                  30          


Arg Val Ala Trp Gly Thr Leu Leu Leu Gln Leu Phe Ile Pro Leu Ser 
        35                  40                  45              


Val Ser Phe Ser Pro Ala Ile Ala Ala Met Lys Ala Ser Lys Ala Asp 
    50                  55                  60                  


Thr Met Val Ser Tyr Ser Ser Thr Glu Pro Tyr Val Leu Gly Ser Gly 
65                  70                  75                  80  


Glu Thr Val Ala Met Val Ala Lys Lys Tyr Gly Ile Thr Val Asp Glu 
                85                  90                  95      


Leu Lys Lys Ile Asn Ile Tyr Arg Thr Phe Ser Arg Pro Phe Thr Ala 
            100                 105                 110         


Leu Thr Thr Gly Asp Glu Ile Asp Ile Pro Arg Lys Ala Ser Pro Phe 
        115                 120                 125             


Ser Val Asp Asn Asn Lys Asp Asn Arg Leu Ser Val Glu Asn Thr Leu 
    130                 135                 140                 


Ala Gly His Ala Val Ala Gly Ala Thr Ala Leu Ser Asn Gly Asp Val 
145                 150                 155                 160 


Ala Lys Ser Gly Glu Arg Met Val Arg Ser Ala Ala Ser Asn Glu Phe 
                165                 170                 175     


Asn Asn Ser Ala Gln Gln Trp Leu Ser Gln Phe Gly Thr Ala Arg Val 
            180                 185                 190         


Gln Leu Asn Ile Asn Asp Asp Phe His Leu Asp Gly Ser Ala Ala Asp 
        195                 200                 205             


Val Leu Ile Pro Leu Tyr Asp Asn Glu Lys Ser Ile Leu Phe Thr Gln 
    210                 215                 220                 


Leu Gly Ala Arg Asn Lys Asp Ser Arg Asn Thr Val Asn Met Gly Ala 
225                 230                 235                 240 


Gly Val Arg Thr Phe Gln Gly Asn Trp Met Tyr Gly Ala Asn Thr Phe 
                245                 250                 255     


Phe Asp Asn Asp Leu Thr Gly Lys Asn Arg Arg Ile Gly Val Gly Ala 
            260                 265                 270         


Glu Ala Trp Thr Asp Tyr Leu Lys Leu Ser Ala Asn Asn Tyr Phe Gly 
        275                 280                 285             


Ile Thr Asp Trp His Gln Ser Arg Asp Phe Ile Asp Tyr Asn Glu Arg 
    290                 295                 300                 


Pro Ala Asn Gly Tyr Asp Leu Arg Ala Glu Ala Tyr Leu Pro Ser Tyr 
305                 310                 315                 320 


Pro Gln Leu Gly Gly Lys Ala Met Tyr Glu Lys Tyr Arg Gly Asp Asp 
                325                 330                 335     


Val Ala Leu Phe Gly Lys Asp Asn Arg Gln Lys Asn Pro His Ala Ile 
            340                 345                 350         


Thr Ala Gly Val Asn Tyr Thr Pro Ile Pro Leu Val Thr Ile Gly Ala 
        355                 360                 365             


Glu His Arg Ala Gly Lys Gly Gly Gln Asn Asp Ser Asn Ile Asn Phe 
    370                 375                 380                 


Gln Leu Asn Tyr Arg Leu Gly Glu Thr Trp Gln Ser His Ile Asp Pro 
385                 390                 395                 400 


Ser Ala Val Ala Ala Ser Arg Thr Leu Ala Gly Ser Arg Tyr Asp Leu 
                405                 410                 415     


Val Glu Arg Asn Asn His Ile Val Leu Asp Tyr Gln Lys Gln Asn Leu 
            420                 425                 430         


Val Arg Leu Ser Leu Pro Asp Ser Leu Ala Gly Asp Pro Phe Ser Gln 
        435                 440                 445             


Leu Ser Val Thr Ala Gln Val Thr Ala Thr His Gly Leu Glu Arg Ile 
    450                 455                 460                 


Asp Trp Gln Ser Ala Glu Leu Met Ala Ala Gly Gly Val Leu Lys Gln 
465                 470                 475                 480 


Thr Ser Lys Asn Gly Leu Glu Ile Thr Leu Pro Glu Tyr Gln Met Asn 
                485                 490                 495     


Arg Thr Gly Gly Asn Ser Tyr Ile Leu Asn Ala Ile Ala Tyr Asp Thr 
            500                 505                 510         


Gln Gly Asn Ala Ser Ser Gln Ala Ser Met Leu Ile Thr Val Asn Ala 
        515                 520                 525             


Gln Lys Ile Asn Ile Ala Asn Ser Thr Leu Val Ala Val Pro Ile Asn 
    530                 535                 540                 


Ile Glu Ala Asn Asn Ser Asp Thr Ser Val Val Thr Leu Thr Leu Lys 
545                 550                 555                 560 


Asp Asp Asn Asn Ile Pro Val Thr Gly Gln Asp Val Thr Phe Leu Ser 
                565                 570                 575     


Pro Leu Gly Thr Leu Ser Ala Met Thr Asp Ser Gly Asn Gly Val Tyr 
            580                 585                 590         


Thr Ala Thr Leu Thr Ala Gly Thr Val Ser Gly Thr Thr Ala Val Ser 
        595                 600                 605             


Ser Asn Ile Asn Gly Ser Ala Leu Asp Met Thr Pro Ala Thr Val Thr 
    610                 615                 620                 


Leu Asn Gly Asn Ser Gly Glu Leu Ser Ile Thr His Ser Met Leu Val 
625                 630                 635                 640 


Ala Ala Pro Val Asn Ile Glu Ala Asn Gly Ser Asp Thr Ser Val Val 
                645                 650                 655     


Thr Leu Thr Leu Arg Asp Ser Asn Asn Asn Pro Val Thr Gly Gln Thr 
            660                 665                 670         


Val Thr Phe Ala Gly Thr Leu Gly Thr Leu Gly Ala Val Thr Glu Gly 
        675                 680                 685             


Ser Ser Gly Val Tyr Thr Ala Thr Leu Thr Ala Gly Ile Met Val Gly 
    690                 695                 700                 


Thr Ser Ser Ile Thr Ala Ser Val Asn Ser Thr Ala Leu Gly Val Thr 
705                 710                 715                 720 


Pro Ala Thr Val Thr Leu Asn Gly Asp Ser Gly Asn Leu Ser Thr Thr 
                725                 730                 735     


Asn Ser Thr Leu Val Ala Ala Pro Val Asn Ile Glu Ala Asn Ser Ser 
            740                 745                 750         


Asp Thr Ser Val Val Thr Leu Thr Leu Arg Asp Asn Asn Asn Asn Pro 
        755                 760                 765             


Val Thr Gly Gln Thr Val Val Phe Thr Ser Thr Leu Gly Thr Leu Gly 
    770                 775                 780                 


Asn Val Thr Glu Gln Ala Ser Gly Val Tyr Thr Ala Thr Leu Thr Ala 
785                 790                 795                 800 


Gly Thr Val Ser Gly Val Ala Ser Leu Ser Val Ser Val Gly Gly Asn 
                805                 810                 815     


Ala Leu Gly Val Thr Pro Ala Thr Val Thr Leu Asn Gly Asp Ser Gly 
            820                 825                 830         


Asn Leu Ser Thr Thr Asn Ser Thr Leu Val Ala Ala Pro Val Asn Ile 
        835                 840                 845             


Glu Ala Asn Ser Ser Asp Thr Ser Val Val Thr Leu Thr Leu Arg Asp 
    850                 855                 860                 


Asn Asn Asn Asn Pro Val Thr Gly Gln Thr Val Asn Phe Ala Gly Thr 
865                 870                 875                 880 


Leu Gly Thr Leu Gly Thr Val Ser Glu Gly Ser Ser Gly Val Tyr Thr 
                885                 890                 895     


Thr Thr Leu Thr Ala Gly Thr Val Ala Gly Val Ala Ser Leu Ser Val 
            900                 905                 910         


Asn Val Gly Gly Asn Ala Leu Gly Val Thr Pro Ala Thr Val Thr Leu 
        915                 920                 925             


Asn Gly Asn Ser Gly Asn Leu Ser Ala Thr Asn Ser Thr Leu Val Ala 
    930                 935                 940                 


Ala Pro Val Asn Ile Glu Ala Asn Ser Ser Asp Thr Ser Val Val Thr 
945                 950                 955                 960 


Leu Thr Leu Arg Asp Asn Asn Asn Asn Pro Val Thr Gly Gln Thr Val 
                965                 970                 975     


Ala Phe Thr Ser Thr Leu Gly Thr Leu Gly Asn Val Thr Glu Gln Ala 
            980                 985                 990         


Ser Gly Val Tyr Thr Ala Thr Leu  Thr Ala Gly Thr Val  Ser Gly Val 
        995                 1000                 1005             


Ala Ser  Leu Ser Val Ser Val  Asn Ser Asn Ala Leu  Gly Val Thr 
    1010                 1015                 1020             


Pro Ala  Thr Val Thr Leu Asn  Gly Asp Ser Gly Asn  Leu Ser Thr 
    1025                 1030                 1035             


Thr Asn  Ser Thr Leu Val Ala  Ala Pro Val Asn Ile  Glu Ala Asn 
    1040                 1045                 1050             


Ser Ser  Asp Thr Ser Val Val  Thr Leu Thr Leu Arg  Asp Asn Asn 
    1055                 1060                 1065             


Asn Asn  Pro Val Thr Gly Gln  Thr Val Ala Phe Thr  Ser Thr Leu 
    1070                 1075                 1080             


Gly Thr  Leu Gly Asn Val Thr  Glu Gln Ala Ser Gly  Leu Tyr Thr 
    1085                 1090                 1095             


Ala Thr  Leu Thr Ala Gly Thr  Val Ser Gly Val Ala  Ser Leu Ser 
    1100                 1105                 1110             


Val Asn  Val Gly Gly Asn Ala  Leu Gly Val Thr Pro  Ala Thr Val 
    1115                 1120                 1125             


Thr Leu  Asn Gly Asp Ser Gly  Asn Leu Ser Ala Thr  Asn Ser Thr 
    1130                 1135                 1140             


Leu Val  Ala Ala Pro Val Asn  Ile Glu Ala Asn Ser  Ser Asp Thr 
    1145                 1150                 1155             


Ser Val  Val Thr Leu Thr Leu  Arg Asp Asn Asn Asn  Asn Pro Val 
    1160                 1165                 1170             


Thr Gly  Gln Thr Val Ala Phe  Thr Ser Thr Leu Gly  Thr Leu Gly 
    1175                 1180                 1185             


Asn Val  Thr Glu Gln Ala Ser  Gly Leu Tyr Thr Ala  Thr Leu Thr 
    1190                 1195                 1200             


Ala Gly  Thr Val Ser Gly Val  Ala Ser Leu Ser Val  Asn Val Gly 
    1205                 1210                 1215             


Gly Thr  Ala Leu Gly Val Thr  Pro Ala Thr Val Thr  Leu Asn Gly 
    1220                 1225                 1230             


Asp Ser  Gly Asn Leu Ser Thr  Thr Asn Ser Thr Leu  Val Ala Ala 
    1235                 1240                 1245             


Pro Val  Asn Ile Glu Ala Asn  Ser Ser Asp Thr Ser  Val Val Thr 
    1250                 1255                 1260             


Leu Thr  Leu Arg Asp Asn Asn  Asn Asn Pro Val Thr  Gly Gln Thr 
    1265                 1270                 1275             


Val Ala  Phe Thr Ser Thr Leu  Gly Thr Leu Gly Asn  Val Thr Glu 
    1280                 1285                 1290             


Gln Ala  Ser Gly Leu Tyr Thr  Ala Thr Leu Thr Ala  Gly Thr Val 
    1295                 1300                 1305             


Ser Gly  Val Ala Ser Leu Ser  Val Ser Val Asn Ser  Thr Ala Leu 
    1310                 1315                 1320             


Gly Val  Thr Pro Ala Thr Val  Thr Leu Asn Gly Asp  Ser Gly Asn 
    1325                 1330                 1335             


Leu Ser  Thr Thr Asn Ser Thr  Leu Val Ala Ala Pro  Val Asn Ile 
    1340                 1345                 1350             


Glu Ala  Asn Ser Ser Asp Thr  Ser Val Val Thr Leu  Thr Leu Arg 
    1355                 1360                 1365             


Asp Asn  Asn Asn Asn Pro Val  Thr Gly Gln Thr Val  Ala Phe Thr 
    1370                 1375                 1380             


Ser Thr  Leu Gly Thr Leu Gly  Asn Val Thr Glu Gln  Ala Ser Gly 
    1385                 1390                 1395             


Val Tyr  Thr Ala Thr Leu Thr  Ala Gly Thr Val Ala  Gly Val Ala 
    1400                 1405                 1410             


Ser Leu  Ser Val Asn Val Gly  Gly Asn Ala Leu Gly  Val Thr Pro 
    1415                 1420                 1425             


Ala Thr  Val Thr Leu Asn Gly  Asp Ser Gly Asn Leu  Ser Thr Thr 
    1430                 1435                 1440             


Asn Ser  Thr Leu Val Ala Ala  Pro Val Asn Ile Glu  Ala Asn Ser 
    1445                 1450                 1455             


Ser Asp  Thr Ser Val Val Thr  Leu Thr Leu Arg Asp  Asn Asn Asn 
    1460                 1465                 1470             


Asn Pro  Val Thr Gly Gln Thr  Val Ala Phe Thr Ser  Thr Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Asn Val Thr Glu  Gln Ala Ser Gly Val  Tyr Thr Ala 
    1490                 1495                 1500             


Thr Leu  Thr Ala Gly Thr Val  Ser Gly Val Ala Ser  Leu Ser Val 
    1505                 1510                 1515             


Ser Val  Gly Ser Ser Ala Leu  Gly Val Thr Pro Ala  Thr Val Thr 
    1520                 1525                 1530             


Leu Asn  Gly Asp Ser Gly Asn  Leu Ser Thr Thr Asn  Ser Thr Leu 
    1535                 1540                 1545             


Val Ala  Ala Pro Val Asn Ile  Glu Ala Asn Asn Ser  Asp Thr Ser 
    1550                 1555                 1560             


Val Val  Thr Leu Thr Leu Arg  Asp Asn Asn Asn Asn  Pro Val Thr 
    1565                 1570                 1575             


Gly Gln  Thr Val Ala Phe Thr  Ser Thr Leu Gly Thr  Leu Gly Asn 
    1580                 1585                 1590             


Val Thr  Glu Gln Ala Ser Gly  Val Tyr Thr Ala Thr  Leu Thr Ala 
    1595                 1600                 1605             


Gly Thr  Val Ser Gly Val Ala  Ser Leu Ser Val Ser  Val Asn Ser 
    1610                 1615                 1620             


Asn Ala  Leu Gly Val Thr Pro  Ala Thr Val Thr Leu  Asn Gly Asp 
    1625                 1630                 1635             


Ser Gly  Asn Leu Ser Thr Thr  Asn Ser Thr Leu Val  Ala Ala Pro 
    1640                 1645                 1650             


Val Asn  Ile Glu Ala Asn Ser  Ser Asp Thr Ser Val  Val Thr Leu 
    1655                 1660                 1665             


Thr Leu  Arg Asp Asn Asn Asn  Asn Pro Val Thr Gly  Gln Thr Val 
    1670                 1675                 1680             


Val Phe  Thr Ser Thr Leu Gly  Thr Leu Gly Asn Val  Thr Glu Gln 
    1685                 1690                 1695             


Ala Ser  Gly Leu Tyr Thr Ala  Thr Leu Thr Ala Gly  Thr Val Ser 
    1700                 1705                 1710             


Gly Val  Ala Ser Leu Ser Val  Ser Val Gly Gly Asn  Ala Leu Gly 
    1715                 1720                 1725             


Val Thr  Gly Asn Ile Thr Leu  Ala Pro Gly Ala Leu  Asp Ala Ala 
    1730                 1735                 1740             


Arg Ser  Ile Leu Ala Val Asn  Lys Pro Ser Ile Asn  Ala Asp Asp 
    1745                 1750                 1755             


Arg Ile  Gly Ser Thr Ile Thr  Phe Thr Ala Gln Asp  Ala Gln Gly 
    1760                 1765                 1770             


Asn Ala  Ile Thr Gly Leu Asp  Ile Ala Phe Met Thr  Asp Leu Glu 
    1775                 1780                 1785             


Asn Ser  Gln Ile Met Thr Leu  Val Asp His Asn Asp  Gly Thr Tyr 
    1790                 1795                 1800             


Thr Ala  Asn Ile Asn Gly Thr  Gln Thr Gly Ile Ala  Asn Ile Ala 
    1805                 1810                 1815             


Val Gln  Ser Ser Gly Ala Thr  Ile Ala Gly Leu Ala  Ala Thr Met 
    1820                 1825                 1830             


Val Thr  Ile Thr Pro Gly Ala  Trp Asn Thr Thr Gln  Ala Thr Pro 
    1835                 1840                 1845             


Val Met  Thr Val Ala Leu Pro  Ile Thr Thr Cys Gln  Ser Ser Ser 
    1850                 1855                 1860             


Gly Val  Tyr Lys Arg Tyr Tyr  Ile Gly Ile Val Thr  His Glu Leu 
    1865                 1870                 1875             


Tyr Asp  Asn Tyr Gly Asn Glu  Ile Ser Gly Ile Leu  Thr Tyr Asn 
    1880                 1885                 1890             


Leu Gly  Ala Gly Arg Tyr Thr  Thr Val Thr Ser Gln  Asn Ser Ser 
    1895                 1900                 1905             


Val Ser  Gly Ser Asn Gly Leu  Thr Arg Arg Ser Asn  
    1910                 1915                 1920 


<210>  6
<211>  835
<212>  PRT
<213>  Yersinia enterocolitica


<220>
<221>  InvA YE2564
<222>  (1)..(835)

<400>  6

Met Tyr Ser Phe Phe Asn Thr Leu Thr Val Thr Lys Ile Ile Ser Arg 
1               5                   10                  15      


Leu Ile Leu Ser Ile Gly Leu Ile Phe Gly Ile Phe Thr Tyr Gly Phe 
            20                  25                  30          


Ser Gln Gln His Tyr Phe Asn Ser Glu Ala Leu Glu Asn Pro Ala Glu 
        35                  40                  45              


His Asn Glu Ala Phe Asn Lys Ile Ile Ser Thr Gly Thr Ser Leu Ala 
    50                  55                  60                  


Val Ser Gly Asn Ala Ser Asn Ile Thr Arg Ser Met Val Asn Asp Ala 
65                  70                  75                  80  


Ala Asn Gln Glu Val Lys His Trp Leu Asn Arg Phe Gly Thr Thr Gln 
                85                  90                  95      


Val Asn Val Asn Phe Asp Lys Lys Phe Ser Leu Lys Glu Ser Ser Leu 
            100                 105                 110         


Asp Trp Leu Leu Pro Trp Tyr Asp Ser Ala Ser Tyr Val Phe Phe Ser 
        115                 120                 125             


Gln Leu Gly Ile Arg Asn Lys Asp Ser Arg Asn Thr Leu Asn Ile Gly 
    130                 135                 140                 


Ala Gly Val Arg Thr Phe Gln Gln Ser Trp Met Tyr Gly Phe Asn Thr 
145                 150                 155                 160 


Phe Tyr Asp Asn Asp Met Thr Gly His Asn His Arg Ile Gly Val Gly 
                165                 170                 175     


Ala Glu Ala Trp Thr Asp Tyr Leu Gln Leu Ser Ala Asn Gly Tyr Phe 
            180                 185                 190         


Arg Leu Asn Gly Trp His Gln Ser Arg Asp Phe Ala Asp Tyr Asn Glu 
        195                 200                 205             


Arg Pro Ala Ser Gly Gly Asp Ile His Val Lys Ala Tyr Leu Pro Ala 
    210                 215                 220                 


Leu Pro Gln Leu Gly Gly Lys Leu Lys Tyr Glu Gln Tyr Arg Gly Glu 
225                 230                 235                 240 


Arg Val Ala Leu Phe Gly Lys Asp Asn Leu Gln Ser Asn Pro Tyr Ala 
                245                 250                 255     


Val Thr Thr Gly Leu Ile Tyr Thr Pro Ile Pro Phe Ile Thr Leu Gly 
            260                 265                 270         


Val Asp Gln Arg Met Gly Lys Ser Arg Gln His Glu Ile Gln Trp Asn 
        275                 280                 285             


Leu Gln Met Asp Tyr Arg Leu Gly Glu Ser Phe Arg Ser Gln Phe Ser 
    290                 295                 300                 


Pro Ala Val Val Ala Gly Thr Arg Leu Leu Ala Glu Ser Arg Tyr Asn 
305                 310                 315                 320 


Leu Val Glu Arg Asn Pro Asn Ile Val Leu Glu Tyr Gln Lys Gln Asn 
                325                 330                 335     


Thr Ile Lys Leu Ala Phe Ser Pro Ala Val Leu Ser Gly Leu Pro Gly 
            340                 345                 350         


Gln Val Tyr Ser Val Ser Ala Gln Ile Gln Ser Gln Ser Ala Leu Gln 
        355                 360                 365             


Arg Ile Leu Trp Asn Asp Ala Gln Trp Val Ala Ala Gly Gly Lys Leu 
    370                 375                 380                 


Ile Pro Val Ser Ala Thr Asp Tyr Asn Val Val Leu Pro Pro Tyr Lys 
385                 390                 395                 400 


Pro Met Ala Pro Ala Ser Arg Thr Val Gly Lys Thr Gly Glu Ser Glu 
                405                 410                 415     


Ala Ala Val Asn Thr Tyr Thr Leu Ser Ala Thr Ala Ile Asp Asn His 
            420                 425                 430         


Gly Asn Ser Ser Asn Pro Ala Thr Leu Thr Val Ile Val Gln Gln Pro 
        435                 440                 445             


Gln Phe Val Ile Thr Ser Glu Val Thr Asp Asp Gly Ala Leu Ala Asp 
    450                 455                 460                 


Gly Arg Thr Pro Ile Thr Val Lys Phe Thr Val Thr Asn Ile Asp Ser 
465                 470                 475                 480 


Thr Pro Val Ala Glu Gln Glu Gly Val Ile Thr Thr Ser Asn Gly Ala 
                485                 490                 495     


Leu Pro Ser Lys Val Thr Lys Lys Thr Asp Ala Gln Gly Val Ile Ser 
            500                 505                 510         


Ile Ala Leu Thr Ser Phe Thr Val Gly Val Ser Val Val Thr Leu Asp 
        515                 520                 525             


Ile Gln Gly Gln Gln Ala Thr Val Asp Val Arg Phe Ala Val Leu Pro 
    530                 535                 540                 


Pro Asp Val Thr Asn Ser Ser Phe Asn Val Ser Pro Ser Asp Ile Val 
545                 550                 555                 560 


Ala Asp Gly Ser Met Gln Ser Ile Leu Thr Phe Val Pro Arg Asn Lys 
                565                 570                 575     


Asn Asn Glu Phe Val Ser Gly Ile Thr Asp Leu Glu Phe Ile Gln Ser 
            580                 585                 590         


Gly Val Pro Val Thr Ile Ser Ser Val Thr Glu Asn Ala Asp Asn Tyr 
        595                 600                 605             


Thr Ala Ser Val Val Gly Asn Ser Val Gly Asp Val Asp Ile Thr Pro 
    610                 615                 620                 


Gln Val Gly Gly Glu Ser Leu Asp Leu Leu Gln Lys Arg Ile Thr Leu 
625                 630                 635                 640 


Tyr Pro Val Pro Lys Ile Thr Gly Ile Lys Val Asn Gly Glu Gln Phe 
                645                 650                 655     


Ala Thr Asp Lys Gly Phe Pro Lys Thr Thr Phe Asn Lys Ala Thr Phe 
            660                 665                 670         


Gln Leu Val Met Asn Asp Asp Val Ala Asn Asn Thr Gln Tyr Asp Trp 
        675                 680                 685             


Thr Ser Ser Tyr Ala Ala Ser Ala Pro Val Asp Asn Gln Gly Lys Val 
    690                 695                 700                 


Asn Ile Ala Tyr Lys Thr Tyr Gly Ser Thr Val Thr Val Thr Ala Lys 
705                 710                 715                 720 


Ser Lys Lys Phe Pro Ser Tyr Thr Ala Thr Tyr Gln Phe Lys Pro Asn 
                725                 730                 735     


Leu Trp Val Phe Ser Gly Thr Met Ser Leu Gln Ser Ser Val Glu Ala 
            740                 745                 750         


Ser Arg Asn Cys Gln Arg Thr Asp Phe Thr Ala Leu Ile Glu Ser Ala 
        755                 760                 765             


Arg Ala Ser Asn Gly Ser Arg Ser Pro Asp Gly Thr Leu Trp Gly Glu 
    770                 775                 780                 


Trp Gly Ser Leu Ala Thr Tyr Asp Ser Ala Glu Trp Pro Ser Gly Asn 
785                 790                 795                 800 


Tyr Trp Thr Lys Lys Thr Ser Thr Asp Phe Val Thr Met Asp Met Thr 
                805                 810                 815     


Thr Gly Asp Ile Pro Thr Ser Ala Ala Thr Ala Tyr Pro Leu Cys Ala 
            820                 825                 830         


Glu Pro Gln 
        835 


<210>  7
<211>  2484
<212>  PRT
<213>  Yersinia enterocolitica


<220>
<221>  InvE YE0694
<222>  (01)..(2484)

<400>  7

Met Gly Ser Ile Phe Lys Gly Ile Glu Arg Tyr Leu Cys Ala Gly Phe 
1               5                   10                  15      


Met Lys Lys Ala Ile Ala Tyr Thr Gln Ile Ile Leu Gln Ile Leu Leu 
            20                  25                  30          


Gly Thr Leu Pro Leu Tyr Ser Met Ser Phe Ser Thr Gln Ala Asn Ser 
        35                  40                  45              


Asp Ile Thr Lys Lys Thr Val Leu Phe Lys Gln Leu His Thr Leu Thr 
    50                  55                  60                  


Pro Thr Asp Thr Leu Glu Ser Val Ala Ala Ser Tyr Gly Leu Ser Val 
65                  70                  75                  80  


Asp Glu Leu Trp Ala Leu Asn Ile Asn Leu Tyr Asn Asn Arg Ser Ala 
                85                  90                  95      


Phe Asp Ala Ile Lys Tyr Gly Ala Val Val Tyr Val Pro Asn Gln Glu 
            100                 105                 110         


Glu Glu Gln Gln Ala Ala Gln Gln Ala Ser Leu Val Ala Ser His Leu 
        115                 120                 125             


Ser Gln Val Gly Asn Ser Leu Ser Ser Glu Asn Arg Val Asp Ala Phe 
    130                 135                 140                 


Ser Arg Leu Ala Lys Gly Ile Leu Leu Ser Ser Thr Ala Lys Thr Val 
145                 150                 155                 160 


Glu Glu Trp Leu Gly His Ile Gly Gln Ala Gln Val Lys Leu Gln Thr 
                165                 170                 175     


Asp Asp Lys Asn Asp Phe Ser Gly Ser Glu Ile Asp Leu Phe Ile Pro 
            180                 185                 190         


Leu Tyr Asp Gln Pro Glu Lys Leu Ala Phe Ser Gln Phe Gly Phe Arg 
        195                 200                 205             


Arg Ile Asp Gln Arg Asn Ile Met Asn Ile Gly Leu Gly Gln Arg His 
    210                 215                 220                 


Tyr Val Ser Asp Trp Met Phe Gly Tyr Asn Ile Phe Phe Asp Gln Gln 
225                 230                 235                 240 


Val Ser Gly Asn Ala His Arg Arg Val Gly Phe Gly Gly Glu Leu Ala 
                245                 250                 255     


Arg Asp Tyr Ile Lys Leu Ser Ala Asn Ser Tyr His Arg Leu Gly Gly 
            260                 265                 270         


Trp Lys Asn Ser Thr Arg Leu Glu Asp Tyr Asp Glu Arg Ala Ala Asn 
        275                 280                 285             


Gly Tyr Asp Ile Arg Thr Glu Ala Tyr Leu Pro His Tyr Pro Gln Leu 
    290                 295                 300                 


Gly Gly Lys Leu Met Tyr Glu Gln Tyr Phe Gly Asp Glu Val Ala Leu 
305                 310                 315                 320 


Phe Gly Ile Asn Glu Arg Gln Lys Asn Pro Ser Ala Leu Thr Ala Gly 
                325                 330                 335     


Val Ser Tyr Thr Pro Ile Pro Leu Val Ser Leu Gly Leu Asp His Thr 
            340                 345                 350         


Ile Gly Asn Gly Gly Lys Lys Lys Thr Gly Val Asn Val Ala Val Asn 
        355                 360                 365             


Tyr Glu Ile Asn Thr Pro Trp Gln Gln Gln Ile Asp Pro Ala Ala Val 
    370                 375                 380                 


Gln Thr Thr Arg Thr Leu Ala Gly Arg Arg Met Asp Leu Val Asp Arg 
385                 390                 395                 400 


Asn Asn Asn Ile Val Leu Glu Tyr Arg Lys Gln Gln Val Val Thr Leu 
                405                 410                 415     


Asn Leu Pro Glu Lys Val Ser Gly Lys Glu Lys Gln Val Val Pro Ile 
            420                 425                 430         


Asn Tyr Thr Phe Asn Ala Arg His Gly Leu Asp Arg Ile Glu Trp Asp 
        435                 440                 445             


Ala Ala Asp Val Ile Lys Ala Gly Gly Gln Val Ile Asn Gln Gly Asn 
    450                 455                 460                 


Leu Ala Tyr Tyr Ile Ala Met Pro Pro Tyr Ile Asp Gly Ala Val Asn 
465                 470                 475                 480 


Ala Tyr Val Leu Ser Gly Arg Ala Ile Asp Lys Lys Gly Asn Tyr Ser 
                485                 490                 495     


Val Ser Gly Ser Thr Asn Val Tyr Val Thr Gly Val Asn Ile Asn Arg 
            500                 505                 510         


Ile Asn Ser Thr Ile Ser Leu Asn Pro Ala Thr Leu Pro Ala Asn Gly 
        515                 520                 525             


Thr Ser Arg Ser Thr Ile Gln Leu Lys Leu Asn Thr Asp Ala Gly Gln 
    530                 535                 540                 


Ala Val Ser Gly Ala Ser Gly Gln Met Thr Phe Ala Ile Arg Asp Ser 
545                 550                 555                 560 


Ser Gly Arg Val Phe Lys Ala Arg Thr Ser Leu Gln Pro Val Val Ile 
                565                 570                 575     


Ser Asp Val Gln Glu Val Gln Thr Gly Val Tyr Glu Ala Ser Ile Thr 
            580                 585                 590         


Ser Gly Phe Leu Thr Gly Arg Phe Glu Ile Thr Pro Thr Val Arg Gly 
        595                 600                 605             


Val Gln Leu Asn Pro Ile Ile Leu Thr Gln Ser Ala Asp Lys Thr Thr 
    610                 615                 620                 


Ala Thr Ile Thr Asp Ser Ser Ala Val Thr Ile Ser Thr Pro Ser Ile 
625                 630                 635                 640 


Thr Thr Asn Ala Thr Asp Lys Thr Lys Leu Glu Val Gln Val Thr Asp 
                645                 650                 655     


Ala Leu Gly His Pro Val Pro Gly Val Glu Val Thr Trp Val Ser Asp 
            660                 665                 670         


Leu Asn Ser Pro Gly Leu Glu Tyr Val Thr Ser Ile Thr Asn Glu His 
        675                 680                 685             


Gly Ile Ala Glu Asn Asn Phe Ser Ser Thr Val Thr Gly Thr Ala Asn 
    690                 695                 700                 


Ile Thr Val Gln Val Gly Thr Ser Ala Pro Val Gln Ala Gly Lys Ile 
705                 710                 715                 720 


Glu Ile Lys Ala Asp Asn Ser Thr Met Thr Val Asn Ala Ser Asp Phe 
                725                 730                 735     


Thr Val Thr Thr Thr Pro Val Val Ala Asn Gly Thr Ser Lys Ala Val 
            740                 745                 750         


Tyr Lys Leu Lys Val Met Asp Lys Gln Gly Asn Val Val Pro Gly Ala 
        755                 760                 765             


Ala Val Asp Trp Leu Ser Asn Ile Gly Thr Phe Val Gln Gly Ser Thr 
    770                 775                 780                 


Thr Thr Thr Asp Thr Asn Gly Glu Thr Phe Ile Glu Leu Val Ser Thr 
785                 790                 795                 800 


Lys Ala Glu Thr Ala Lys Val Thr Ala Thr Val Gly Gly Lys Pro Tyr 
                805                 810                 815     


Asn Ala Gly Lys Val Val Phe Val Ala Asp Arg Gln Ser Gly Lys Ile 
            820                 825                 830         


Thr Leu Leu Pro Val Ser Lys Asn Thr Ala Ala Ala Asn Gly Thr Asp 
        835                 840                 845             


Ser Ile Thr Leu Asn Ala Lys Ile Leu Asp Ala Asn Gly Asn Pro Ile 
    850                 855                 860                 


Lys Asn Glu Glu Ile Glu Trp Asp Ala Ala Ser His Lys Val Thr Phe 
865                 870                 875                 880 


Ser Pro Ala Thr Gly Lys Thr Gln Thr Asn Asp Leu Gly Glu Thr Gln 
                885                 890                 895     


Ile Thr Leu Thr Ser Thr Asp Val Gly Asp Ile Thr Leu Asn Ala Gln 
            900                 905                 910         


Val Val Lys Asn Asn Leu Leu Val Asn Gln Ala Gly Glu Lys Leu Ser 
        915                 920                 925             


Phe Thr Ala Asp Thr Val Thr Ala Asn Ile Ser Ala Trp Ser Ala Pro 
    930                 935                 940                 


Ser Val Lys Thr Leu Ile Ala Asp Gly Gln Ala Gln Val Ile Tyr Lys 
945                 950                 955                 960 


Val Val Val Lys Asp Lys Asn Gly His Val Val Pro Asn Ser Pro Val 
                965                 970                 975     


Leu Trp Glu Thr Asn Leu Gly Glu Phe Val Pro Ala Gln Ala Thr Thr 
            980                 985                 990         


Thr Met Thr Ser Thr Asp Ser Gln  Gly Glu Ala Thr Val  Val Leu Ala 
        995                 1000                 1005             


Ser Ile  Lys Ala Gly Ser Ala  Thr Val Lys Ala Ser  Val Asn Ala 
    1010                 1015                 1020             


Asn Lys  Asp Thr Ser Pro Thr  Gln Val Glu Phe Thr  Ala Asp Ser 
    1025                 1030                 1035             


Ser Thr  Ala Thr Ile Ala Ile  Thr Pro Val Thr Lys  Gln Val Tyr 
    1040                 1045                 1050             


Val Ala  Asn Gly Ser Glu Lys  Val Thr Tyr Ala Val  Thr Val Leu 
    1055                 1060                 1065             


Asp Ala  Asn Asn Asn Pro Val  Lys Ala Glu Ala Ile  Asn Trp Lys 
    1070                 1075                 1080             


Ser Glu  Asn Gly His Pro Val  Lys Val Glu Pro Ala  Pro Ser Gln 
    1085                 1090                 1095             


Thr Asp  Gly Gln Gly Lys Ala  Thr Val Ser Ile Gly  Ser Val Lys 
    1100                 1105                 1110             


Ala Gly  Asp Thr Gln Ile Arg  Ala Thr Leu Gly Asn  Asn Ala Thr 
    1115                 1120                 1125             


Ala Ile  Ala Asp Ala Ile Thr  Phe Glu Ala Asp Arg  Gln Thr Ala 
    1130                 1135                 1140             


Val Val  Lys Thr Val Glu Val  Thr Gly Ser Lys Val  Thr Ala Pro 
    1145                 1150                 1155             


Asp Gly  Thr Gly Ser Ile Ser  Tyr Val Thr Thr Val  Val Asp Ala 
    1160                 1165                 1170             


Asn Gly  Asn Pro Val Ser Gly  Met Ile Leu Ser Trp  Gly Ser Asn 
    1175                 1180                 1185             


Ile Asn  Asn Val Ala Asn Pro  Ser Thr Thr Thr Asp  Ile Asn Gly 
    1190                 1195                 1200             


Gln Ser  Ser Gln Thr Ile Thr  Gly Thr Gln Ala Gly  Lys Val Glu 
    1205                 1210                 1215             


Ile Ser  Val Ala Leu Thr Ser  Gly Asn Asn Ala Thr  Asn Pro Val 
    1220                 1225                 1230             


Lys Asn  Ser Asn Asn Ala Glu  Phe Val Ala Val Thr  Pro Val Met 
    1235                 1240                 1245             


Ala Asn  Ala Asp Leu Leu Leu  Gln Pro Asn Leu Ile  Ile Ala Asn 
    1250                 1255                 1260             


Gly Lys  Gln Thr Ala Thr Leu  Lys Phe Thr Leu Arg  Asp Ala Asn 
    1265                 1270                 1275             


His Asn  Pro Val Ser Gly Leu  Lys Gln Arg Ile Asp  Val Thr Gln 
    1280                 1285                 1290             


Ser Val  Ala Ser His Val Thr  Ile Gly Ala Val Thr  Glu Thr Thr 
    1295                 1300                 1305             


Val Lys  Gly Val Tyr Gln Ala  Ala Ile Thr Gly Met  Lys Glu Asn 
    1310                 1315                 1320             


Ser Val  Asp Leu Thr Ala Ser  Val Lys Gly Thr Asn  Val Arg Gln 
    1325                 1330                 1335             


Thr Arg  Thr Leu Thr Leu Gln  Ala Asp Asn Lys Thr  Ala Thr Leu 
    1340                 1345                 1350             


Lys Thr  Val Thr Ser Asn Ile  Lys Thr Ala Lys Ala  Asp Gly Lys 
    1355                 1360                 1365             


Glu Ser  Ile Thr Tyr Arg Ala  Lys Val Ile Asp Ala  Gln Gly Asn 
    1370                 1375                 1380             


Ala Ser  Leu Asp Asn Val Ser  Val Gly Trp Arg Thr  Thr Leu Gly 
    1385                 1390                 1395             


Glu Leu  Ala Ala Ile Thr Lys  Thr Asp Thr Ser Gly  Ile Ala Thr 
    1400                 1405                 1410             


Val Thr  Leu Thr Ser Lys Gln  Ala Gly Ser Ala Thr  Val Thr Ala 
    1415                 1420                 1425             


Ile Val  Ser Ser Thr Ser Glu  Met Lys Ala Ala Pro  Val Asn Phe 
    1430                 1435                 1440             


Thr Ala  Gly Gly Ile Ser Ile  Thr Gln Ser Thr Ala  Ser Leu Ser 
    1445                 1450                 1455             


Val Lys  Asp Leu Val Ala Asp  Asp Val Ile Thr Thr  Lys Leu Thr 
    1460                 1465                 1470             


Val Asn  Ile Lys Asp Asp Asn  Gly Asn Pro Leu Thr  Gly Lys Gly 
    1475                 1480                 1485             


Ser Glu  Ile Ser Val Thr Ala  Thr Gly Leu Ala Gly  Leu Lys Leu 
    1490                 1495                 1500             


Pro Thr  Thr Phe Val Glu Gly  Pro Asn Gly Val Tyr  Thr Ala Thr 
    1505                 1510                 1515             


Ile Thr  Gly Thr Lys Ala Gly  Val Gly Asp Ile Val  Thr Ala Leu 
    1520                 1525                 1530             


Ala Gly  Lys Glu Leu Ala Lys  Gln Gln Leu Lys Val  Ile Ala Asp 
    1535                 1540                 1545             


Val Gln  Thr Ala Lys Ile Ala  Asp Ile Lys Pro Leu  Lys Ser Gly 
    1550                 1555                 1560             


Ser Val  Ser Val Gly Asp Lys  Val Thr Tyr Gln Ala  Thr Leu Lys 
    1565                 1570                 1575             


Asp Ala  Asn Asp Asn Leu Leu  Gly Ala Gly Ile Pro  Val His Trp 
    1580                 1585                 1590             


Ser Val  Asn Arg Asp Thr Leu  Met Ser Gly Lys Leu  Ile Ser Leu 
    1595                 1600                 1605             


Thr Asn  Ser Ala Gly Val Ala  Glu Val Glu Ile Ser  Arg Asp Leu 
    1610                 1615                 1620             


Ala Gly  Asp Ala Leu Val Thr  Ala Ala Val Gly Asn  Asn Ser Leu 
    1625                 1630                 1635             


Gln Ala  Thr Ala Val Lys Phe  Ile Ser Gly Gly Val  Asp Ile Ser 
    1640                 1645                 1650             


Lys Ser  Ser Met Gln Leu Leu  Gln Gly Asn Ile Thr  Ala Asp Asn 
    1655                 1660                 1665             


Leu Asp  Ile Ala Thr Ile Gln  Val Asp Ile Arg Asp  Ser Lys Gly 
    1670                 1675                 1680             


Asn Pro  Leu Pro Asn Leu Ala  Ser Gln Ile Thr Thr  Ser Pro Lys 
    1685                 1690                 1695             


Lys Gly  Glu His Gly Leu Lys  Ile Glu Thr Ile Ala  Asn Pro Ser 
    1700                 1705                 1710             


Gly Asp  Gly Tyr Leu Val Lys  Met Lys Gly Thr Gln  Ala Gly Asn 
    1715                 1720                 1725             


His Thr  Val Thr Val Ser Val  Ala Gly Lys Pro Leu  Ser Ala Lys 
    1730                 1735                 1740             


Val Asp  Met Val Leu Lys Gly  Asp Ala Thr Thr Ala  Lys Ile Glu 
    1745                 1750                 1755             


Ser Val  Lys Ser Ser Ser Pro  Thr Phe Lys Ala Asp  Asn Val Asp 
    1760                 1765                 1770             


Thr Val  Thr Tyr Thr Ala Lys  Val Val Asp Ala Asn  Asn Asn Leu 
    1775                 1780                 1785             


Leu Glu  Asn Ile Ala Val Ser  Trp Arg Leu Ala Gln  Gly Glu Gly 
    1790                 1795                 1800             


Gln Tyr  Gln Gly Gln Ser Tyr  Thr Gly Lys Thr Gly  Val Ala Thr 
    1805                 1810                 1815             


Thr Lys  Leu Ser Ala Ser Arg  Leu Gly Thr Tyr Lys  Met Glu Ala 
    1820                 1825                 1830             


Gln Val  Arg Gln Gln Val Lys  Ala Ala Ala Gly Val  Asn Ser Thr 
    1835                 1840                 1845             


Ala Gly  Asp Ala Asp Pro Ser  Gln Ser Asp Phe Val  Val Asp Val 
    1850                 1855                 1860             


Ala Ser  Ile Asp Ser Ser Gly  Asn Thr Lys Ala Lys  Leu Thr Ala 
    1865                 1870                 1875             


Thr Leu  Lys Asp Lys Phe Gly  Asn Leu Leu Ser Gly  Gln Lys Val 
    1880                 1885                 1890             


Lys Leu  Thr Asp Ser Asn Ser  Leu Lys Lys Ile Thr  Leu Ser Ala 
    1895                 1900                 1905             


Asn Pro  Met Lys Asp Asn Gly  Asp Gly Thr Tyr Ser  Thr Glu Val 
    1910                 1915                 1920             


Thr Ala  Thr Ala Lys Gly Asn  Thr Arg Phe Ile Ala  Arg Val Asn 
    1925                 1930                 1935             


Gly Val  Asp Leu Thr Gln Gln  Pro Gln Ile Val Ile  Gly Asn Ile 
    1940                 1945                 1950             


Ile Pro  Gln Leu Ser Phe Ala  Lys Ser Lys Glu Ala  Thr Thr Tyr 
    1955                 1960                 1965             


Ser Arg  Lys Val His Lys Pro  Leu Ser Leu Thr Gly  Leu Pro Ser 
    1970                 1975                 1980             


Ser Ala  Thr Leu Thr Ala His  Trp Ser Ser Asp Asn  Ser Asp Val 
    1985                 1990                 1995             


Ala Thr  Val Asn Pro Leu Asn  Gly Glu Leu Thr Leu  Leu Lys Ala 
    2000                 2005                 2010             


Gly Val  Val Asn Ile Ser Val  Leu Thr Leu Pro Thr  Asp Thr Tyr 
    2015                 2020                 2025             


Thr Ser  Gly Thr Ala Asn Tyr  Gln Leu Thr Val Glu  Lys Ala Asp 
    2030                 2035                 2040             


Pro Gly  Ile Asn Phe Ala Val  Ala Lys Arg Asp Val  Lys Trp Met 
    2045                 2050                 2055             


Asp Ser  Met Ser Pro Gln Asn  Phe Val Leu Ser Asn  Ser Asp Ala 
    2060                 2065                 2070             


Asn Gln  Ser Asp Ile Lys Thr  Ile Trp Gln Thr Asp  Ser Gly Lys 
    2075                 2080                 2085             


Ile Ala  Thr Val Asp Lys Gly  Gly Leu Val Thr Leu  Val Lys Pro 
    2090                 2095                 2100             


Gly Thr  Thr Asn Val Thr Val  Ser Phe Val Gly Asp  Glu Arg Phe 
    2105                 2110                 2115             


Lys Tyr  Gly Glu Ala Ser Tyr  Glu Leu Asn Val Ala  Lys Tyr Lys 
    2120                 2125                 2130             


Pro Thr  Val Ser Phe Ala Asn  Ser Leu Leu Thr Asn  Lys Val Ser 
    2135                 2140                 2145             


Glu Lys  Ile Tyr Val Gln Lys  Pro Asp Glu Lys Leu  Ser Thr Tyr 
    2150                 2155                 2160             


Ala His  Leu Glu Thr Lys Trp  Ser Ser Ser Asp Asn  Ala Ile Val 
    2165                 2170                 2175             


Glu Val  Ala Asn Asp Ala Ser  Tyr Met Ser Pro Lys  Gly Pro Gly 
    2180                 2185                 2190             


Lys Ala  Arg Ile Thr Leu Gln  Val Val Gly Asn Asp  Trp Tyr Glu 
    2195                 2200                 2205             


Glu Gln  Ser Ser Ser Tyr Glu  Gln Glu Val Tyr Ala  Thr Pro Lys 
    2210                 2215                 2220             


Val Ser  Ile Arg Glu Thr Thr  Ala Ile Ser Asn Ser  Val Lys Lys 
    2225                 2230                 2235             


Val Asn  Glu Arg Val Trp Ser  Pro Val Phe Thr Asn  Asp Asn Phe 
    2240                 2245                 2250             


Gly Val  Thr Val Asp Asn Ser  Gln Ser Lys Tyr Glu  Arg Ala Asp 
    2255                 2260                 2265             


Ser Val  Lys Val Ile Leu Leu  Asp Gly Thr Gln Glu  Leu Ala Ser 
    2270                 2275                 2280             


Lys Glu  Leu Gly Ile Thr Thr  Ser Ser Ser Phe Glu  Phe Lys Pro 
    2285                 2290                 2295             


Lys Pro  Asp Trp Val Gly Lys  Ser Leu Lys Val Lys  Val Val Ala 
    2300                 2305                 2310             


Lys Asn  Asp Val Arg Gln Glu  Asn Glu Val Thr Leu  Asp His Glu 
    2315                 2320                 2325             


Val Arg  Val Gly Thr Leu Glu  Pro Ile Asp Ile Trp  Gln Asn Ala 
    2330                 2335                 2340             


Ile Phe  Thr Arg Asn Tyr Ser  Leu His Asn Asn Asp  Gly Ser Lys 
    2345                 2350                 2355             


Arg Asp  Ser Cys Pro Ile Val  Asn Asn Leu Phe Tyr  Pro Asn Tyr 
    2360                 2365                 2370             


Ala Arg  Leu Asn Trp Arg Met  Gln Leu Val Leu Asn  Lys Asp Met 
    2375                 2380                 2385             


Leu His  Pro Met Gln Ile Thr  Lys Leu Glu Ser Lys  Thr Ser Lys 
    2390                 2395                 2400             


His Gly  Ile Asn Met Thr His  Ile Asp Ser Ser Thr  Ser Glu Ile 
    2405                 2410                 2415             


Phe Asp  Ser Tyr Asp Asn Lys  Asp Asp Asn Arg Leu  Ile Asn Lys 
    2420                 2425                 2430             


Cys Ile  Lys Glu Lys Tyr Gly  Thr Tyr Lys Thr Tyr  Met Asp Ile 
    2435                 2440                 2445             


Lys Tyr  Ala Gly Arg Glu Tyr  Lys Tyr Glu Ala Ile  Asn Asp Leu 
    2450                 2455                 2460             


Tyr Trp  Glu Gly Glu Gly Asp  Asp Arg Glu Ser Asp  Lys Ser Ser 
    2465                 2470                 2475             


Gly Phe  Lys Lys Val Pro 
    2480                 


<210>  8
<211>  432
<212>  PRT
<213>  Yersinia pseudotuberculosis


<220>
<221>  YadA pYV0013
<222>  (01)..(432)

<400>  8

Met Thr Lys Asp Phe Lys Ile Ser Val Ser Ala Ala Leu Ile Ser Ala 
1               5                   10                  15      


Leu Phe Ser Ser Pro Tyr Ala Phe Ala Glu Glu Pro Glu Asp Gly Asn 
            20                  25                  30          


Asp Gly Ile Pro Arg Leu Ser Ala Val Gln Ile Ser Pro Asn Val Asp 
        35                  40                  45              


Pro Lys Leu Gly Val Gly Leu Tyr Pro Ala Lys Pro Ile Leu Arg Gln 
    50                  55                  60                  


Glu Asn Pro Lys Leu Pro Pro Arg Gly Pro Gln Gly Pro Glu Lys Lys 
65                  70                  75                  80  


Arg Ala Arg Leu Ala Glu Ala Ile Gln Pro Gln Val Leu Gly Gly Leu 
                85                  90                  95      


Asp Ala Arg Ala Lys Gly Ile His Ser Ile Ala Ile Gly Ala Thr Ala 
            100                 105                 110         


Glu Ala Ala Lys Pro Ala Ala Val Ala Val Gly Ala Gly Ser Ile Ala 
        115                 120                 125             


Thr Gly Val Asn Ser Val Ala Ile Gly Pro Leu Ser Lys Ala Leu Gly 
    130                 135                 140                 


Asp Ser Ala Val Thr Tyr Gly Ala Ser Ser Thr Ala Gln Lys Asp Gly 
145                 150                 155                 160 


Val Ala Ile Gly Ala Arg Ala Ser Ala Ser Asp Thr Gly Val Ala Val 
                165                 170                 175     


Gly Phe Asn Ser Lys Val Asp Ala Gln Asn Ser Val Ala Ile Gly His 
            180                 185                 190         


Ser Ser His Val Ala Ala Asp His Gly Tyr Ser Ile Ala Ile Gly Asp 
        195                 200                 205             


Leu Ser Lys Thr Asp Arg Glu Asn Ser Val Ser Ile Gly His Glu Ser 
    210                 215                 220                 


Leu Asn Arg Gln Leu Thr His Leu Ala Ala Gly Thr Lys Asp Asn Asp 
225                 230                 235                 240 


Ala Val Asn Val Ala Gln Leu Lys Lys Glu Met Ala Glu Thr Leu Glu 
                245                 250                 255     


Asn Ala Arg Lys Glu Thr Leu Ala Gln Ser Asn Asp Val Leu Asp Ala 
            260                 265                 270         


Ala Lys Lys His Ser Asn Ser Val Ala Arg Thr Thr Leu Glu Thr Ala 
        275                 280                 285             


Glu Glu His Ala Asn Lys Lys Ser Ala Glu Ala Leu Val Ser Ala Lys 
    290                 295                 300                 


Val Tyr Ala Asp Ser Asn Ser Ser His Thr Leu Lys Thr Ala Asn Ser 
305                 310                 315                 320 


Tyr Thr Asp Val Thr Val Ser Ser Ser Thr Lys Lys Ala Ile Ser Glu 
                325                 330                 335     


Ser Asn Gln Tyr Thr Asp His Lys Phe Ser Gln Leu Asp Asn Arg Leu 
            340                 345                 350         


Asp Lys Leu Asp Lys Arg Val Asp Lys Gly Leu Ala Ser Ser Ala Ala 
        355                 360                 365             


Leu Asn Ser Leu Phe Gln Pro Tyr Gly Val Gly Lys Val Asn Phe Thr 
    370                 375                 380                 


Ala Gly Val Gly Gly Tyr Arg Ser Ser Gln Ala Leu Ala Ile Gly Ser 
385                 390                 395                 400 


Gly Tyr Arg Val Asn Glu Ser Val Ala Leu Lys Ala Gly Val Ala Tyr 
                405                 410                 415     


Ala Gly Ser Ser Asn Val Met Tyr Asn Ala Ser Phe Asn Ile Glu Trp 
            420                 425                 430         


<210>  9
<211>  422
<212>  PRT
<213>  Yersinia enterocolitica


<220>
<221>  YadA Yep0066
<222>  (1)..(422)

<400>  9

Met Thr Lys Asp Phe Lys Ile Ser Val Ser Ala Ala Leu Ile Ser Ala 
1               5                   10                  15      


Leu Phe Ser Ser Pro Tyr Ala Phe Ala Asn Asn Asp Glu Val His Phe 
            20                  25                  30          


Thr Ala Val Gln Ile Ser Pro Asn Ala Asp Pro Asp Ser His Val Val 
        35                  40                  45              


Ile Phe Gln Pro Ala Ala Glu Ala Leu Gly Gly Thr Asn Ala Leu Ala 
    50                  55                  60                  


Lys Ser Ile His Ser Ile Ala Val Gly Ala Ser Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Gln Ala Ala Val Ala Val Gly Ala Gly Ser Ile Ala Thr Gly Val Asn 
                85                  90                  95      


Ser Val Ala Ile Gly Pro Leu Ser Lys Ala Leu Gly Asp Ser Ala Val 
            100                 105                 110         


Thr Tyr Gly Ala Ala Ser Thr Ala Gln Lys Asp Gly Val Ala Ile Gly 
        115                 120                 125             


Ala Arg Ala Phe Thr Ser Asp Thr Gly Val Ala Val Gly Phe Asn Ser 
    130                 135                 140                 


Lys Val Asp Ala Lys Asn Ser Val Ala Ile Gly His Ser Ser His Val 
145                 150                 155                 160 


Ala Val Asp His Asp Tyr Ser Ile Ala Ile Gly Asp Arg Ser Lys Thr 
                165                 170                 175     


Asp Arg Lys Asn Ser Val Ser Ile Gly His Glu Ser Leu Asn Arg Gln 
            180                 185                 190         


Leu Thr His Leu Ala Ala Gly Thr Lys Asp Thr Asp Ala Val Asn Val 
        195                 200                 205             


Ala Gln Leu Lys Lys Glu Ile Glu Lys Thr Gln Val Asn Ala Asn Lys 
    210                 215                 220                 


Lys Ser Ala Glu Val Leu Gly Ile Ala Asn Asn Tyr Thr Asp Ser Lys 
225                 230                 235                 240 


Ser Ala Glu Thr Leu Glu Asn Ala Arg Lys Glu Ala Phe Asp Leu Ser 
                245                 250                 255     


Asn Asp Ala Leu Asp Met Ala Lys Lys His Ser Asn Ser Val Ala Arg 
            260                 265                 270         


Thr Thr Leu Glu Thr Ala Glu Glu His Thr Asn Lys Lys Ser Ala Glu 
        275                 280                 285             


Thr Leu Ala Arg Ala Asn Val Tyr Ala Asp Ser Lys Ser Ser His Thr 
    290                 295                 300                 


Leu Gln Thr Ala Asn Ser Tyr Thr Asp Val Thr Val Ser Asn Ser Thr 
305                 310                 315                 320 


Lys Lys Ala Ile Arg Glu Ser Asn Gln Tyr Thr Asp His Lys Phe Arg 
                325                 330                 335     


Gln Leu Asp Asn Arg Leu Asp Lys Leu Asp Thr Arg Val Asp Lys Gly 
            340                 345                 350         


Leu Ala Ser Ser Ala Ala Leu Asn Ser Leu Phe Gln Pro Tyr Gly Val 
        355                 360                 365             


Gly Lys Val Asn Phe Thr Ala Gly Val Gly Gly Tyr Arg Ser Ser Gln 
    370                 375                 380                 


Ala Leu Ala Ile Gly Ser Gly Tyr Arg Val Asn Glu Ser Val Ala Leu 
385                 390                 395                 400 


Lys Ala Gly Val Ala Tyr Ala Gly Ser Ser Asp Val Met Tyr Asn Ala 
                405                 410                 415     


Ser Phe Asn Ile Glu Trp 
            420         


