                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Mendez, Aaron S.
       Shokat, Kevan M.
 
<120>  MODULATORS OF IRE1

<130>  48536-555001WO

<150>  US 62/033,889
<151>  2014-08-06

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  2
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg 
            20                  25                  30          


Ala Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly 
        35                  40                  45              


Ala Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala 
    50                  55                  60                  


Val Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala 
65                  70                  75                  80  


Ala Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr 
                85                  90                  95      


Glu Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp 
            100                 105                 110         


Gly Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp 
        115                 120                 125             


Asp Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys 
    130                 135                 140                 


Pro Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala 
145                 150                 155                 160 


Leu Phe Gln Trp Asp Gln Asp Arg Glu Ser Met Glu Thr Val Pro Phe 
                165                 170                 175     


Thr Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val 
            180                 185                 190         


Val Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr 
        195                 200                 205             


Ser Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp 
    210                 215                 220                 


Asp Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg 
225                 230                 235                 240 


Thr Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys 
                245                 250                 255     


Trp Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met 
            260                 265                 270         


Glu Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn 
        275                 280                 285             


Thr Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala 
    290                 295                 300                 


Ile Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met 
305                 310                 315                 320 


Ala Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys 
                325                 330                 335     


Thr Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro 
            340                 345                 350         


Ile Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu 
        355                 360                 365             


Glu Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn 
    370                 375                 380                 


Ser Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser 
385                 390                 395                 400 


Val Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser 
                405                 410                 415     


Val Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys 
            420                 425                 430         


Pro Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp 
        435                 440                 445             


Glu Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr 
    450                 455                 460                 


Ser Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr 
465                 470                 475                 480 


Tyr Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile 
                485                 490                 495     


Thr Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys 
            500                 505                 510         


Lys Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr 
        515                 520                 525             


Ile Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe 
    530                 535                 540                 


His Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln 
545                 550                 555                 560 


Thr Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser 
                565                 570                 575     


Trp Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp 
            580                 585                 590         


Phe Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe 
        595                 600                 605             


Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile 
    610                 615                 620                 


Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val 
625                 630                 635                 640 


Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn 
                645                 650                 655     


Ala Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu 
            660                 665                 670         


Ile Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser 
        675                 680                 685             


Pro Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ala 
    690                 695                 700                 


Thr Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg 
705                 710                 715                 720 


Ser Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser 
                725                 730                 735     


Gln Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser 
            740                 745                 750         


Glu Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp 
        755                 760                 765             


Cys Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser 
    770                 775                 780                 


Phe Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu 
785                 790                 795                 800 


Arg Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala 
                805                 810                 815     


Ser Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His 
            820                 825                 830         


Cys Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser 
        835                 840                 845             


Ser Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser 
    850                 855                 860                 


Leu Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro 
865                 870                 875                 880 


Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu 
                885                 890                 895     


Lys Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser 
            900                 905                 910         


Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu 
        915                 920                 925             


His Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe 
    930                 935                 940                 


Phe Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr 
945                 950                 955                 960 


Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro 
                965                 970                 975     


Ala Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser 
            980                 985                 990         


Pro Glu Gln Ile His Gly Asn Ser  Tyr Ser His Lys Val  Asp Ile Phe 
        995                 1000                 1005             


Ser Leu  Gly Leu Ile Leu Phe  Glu Leu Leu Tyr Pro  Phe Ser Thr 
    1010                 1015                 1020             


Gln Met  Glu Arg Val Arg Thr  Leu Thr Asp Val Arg  Asn Leu Lys 
    1025                 1030                 1035             


Phe Pro  Pro Leu Phe Thr Gln  Lys Tyr Pro Cys Glu  Tyr Val Met 
    1040                 1045                 1050             


Val Gln  Asp Met Leu Ser Pro  Ser Pro Met Glu Arg  Pro Glu Ala 
    1055                 1060                 1065             


Ile Asn  Ile Ile Glu Asn Ala  Val Phe Glu Asp Leu  Asp Phe Pro 
    1070                 1075                 1080             


Gly Lys  Thr Val Leu Arg Gln  Arg Ser Arg Ser Leu  Ser Ser Ser 
    1085                 1090                 1095             


Gly Thr  Lys His Ser Arg Gln  Ser Asn Asn Ser His  Ser Pro Leu 
    1100                 1105                 1110             


Pro Ser  Asn 
    1115     


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
ttacgagaga aaactcatgg c                                                 21


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
gggtccaagt tgtccagaat gc                                                22


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
gaaccaggag ttaagaacac g                                                 21


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
aggcaacagt gtcgagtcc                                                    19


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
agttccactc tttgatggag ggca                                              24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
agccagctgt gaggaatatg ggaa                                              24


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
acaaggtggc cctattgtgg aaga                                              24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
agtccattcc tgtcaaagcc tcca                                              24


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
ccatgttcgt catgggtgtg a                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
catggactgt ggtcatgagt                                                   20


<210>  13
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligoribonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Terminal modified with FAM

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Terminal modified with IABlk_FQ

<400>  13
caccucugca gcaggug                                                      17


<210>  14
<211>  4005
<212>  DNA
<213>  Homo sapiens

<400>  14
tgcctagtca gttctgcgtc cgctgaggct cggtcaccgc ctcgctgtcg tcgcggcgcc       60

cccgccccgt cctctgtccg taccgccccc ggagccaggg ccgagtcctc gccatgccgg      120

cccggcggct gctgctgctg ctgacgctgc tgctgcccgg cctcgggatt tttggaagta      180

ccagcacagt gacgcttcct gaaaccttgt tgtttgtgtc aacgctggat ggaagtttgc      240

atgctgtcag caagaggaca ggctcaatca aatggacttt aaaagaagat ccagtcctgc      300

aggtcccaac acatgtggaa gagcctgcct ttctcccaga tcctaatgat ggcagcctgt      360

atacgcttgg aagcaagaat aatgaaggcc tgacgaaact tccttttacc atcccagaat      420

tggtgcaggc atccccatgc cgaagttcag atggaatcct ctacatgggt aaaaagcagg      480

acatctggta tgttattgac ctcctgaccg gagagaagca gcagactttg tcatcggcct      540

ttgcagatag tctctgccca tcaacctctc ttctgtatct tgggcgaaca gaatacacca      600

tcaccatgta cgacaccaaa acccgagagc tccggtggaa tgccacctac tttgactatg      660

cggcctcact gcctgaggac gacgtggact acaagatgtc ccactttgtg tccaatggtg      720

atgggctggt ggtgactgtg gacagtgaat ctggggacgt cctgtggatc caaaactacg      780

cctcccctgt ggtggccttt tatgtctggc agcgggaggg tctgaggaag gtgatgcaca      840

tcaatgtcgc tgtggagacc ctgcgctatc tgaccttcat gtctggggag gtggggcgca      900

tcacaaagtg gaagtacccg ttccccaagg agacagaggc caagagcaag ctgacgccca      960

ctctgtatgt tgggaaatac tctaccagcc tctatgcctc tccctcaatg gtacacgagg     1020

gggttgctgt cgtgccccgc ggcagcacac ttcctttgct ggaagggccc cagactgatg     1080

gcgtcaccat tggggacaag ggggagtgtg tgatcacgcc cagcacggac gtcaagtttg     1140

atcccggact caaaagcaag aacaagctca actacttgag gaattactgg cttctgatag     1200

gacaccatga aaccccactg tctgcgtcta ccaagatgct ggagagattt cccaacaatc     1260

tacccaaaca tcgggaaaat gtgattcctg ctgattcaga gaaaaagagc tttgaggaag     1320

ttatcaacct ggttgaccag acttcagaaa acgcacctac caccgtgtct cgggatgtgg     1380

aggagaagcc cgcccatgcc cctgcccggc ccgaggcccc cgtggactcc atgcttaagg     1440

acatggctac catcatcctg agcaccttcc tgctgattgg ctgggtggcc ttcatcatca     1500

cctatcccct gagcatgcat cagcagcagc agctccagca ccagcagttc cagaaggaac     1560

tggagaagat ccagctcctg cagcagcagc agcagcagct gcccttccac ccacctggag     1620

acacggctca ggacggcgag ctcctggaca cgtctggccc gtactcagag agctcgggca     1680

ccagcagccc cagcacgtcc cccagggcct ccaaccactc gctctgctcc ggcagctctg     1740

cctccaaggc tggcagcagc ccctccctgg aacaagacga tggagatgag gaaaccagcg     1800

tggtgatagt tgggaaaatt tccttctgtc ccaaggatgt cctgggccat ggagctgagg     1860

gcacaattgt gtaccggggc atgtttgaca accgcgacgt ggccgtgaag aggatcctcc     1920

ccgagtgttt tagcttcgca gaccgtgagg tccagctgtt gcgagaatcg gatgagcacc     1980

cgaacgtgat ccgctacttc tgcacggaga aggaccggca attccagtac attgccatcg     2040

agctgtgtgc agccaccctg caagagtatg tggagcagaa ggactttgcg catctcggcc     2100

tggagcccat caccttgctg cagcagacca cctcgggcct ggcccacctc cactccctca     2160

acatcgttca cagagaccta aagccacaca acatcctcat atccatgccc aatgcacacg     2220

gcaagatcaa ggccatgatc tccgactttg gcctctgcaa gaagctggca gtgggcagac     2280

acagtttcag ccgccgatct ggggtgcctg gcacagaagg ctggatcgct ccagagatgc     2340

tgagcgaaga ctgtaaggag aaccctacct acacggtgga catcttttct gcaggctgcg     2400

tcttttacta cgtaatctct gagggcagcc acccttttgg caagtccctg cagcggcagg     2460

ccaacatcct cctgggtgcc tgcagccttg actgcttgca cccagagaag cacgaagacg     2520

tcattgcacg tgaattgata gagaagatga ttgcgatgga tcctcagaaa cgcccctcag     2580

cgaagcatgt gctcaaacac ccgttcttct ggagcctaga gaagcagctc cagttcttcc     2640

aggacgtgag cgacagaata gaaaaggaat ccctggatgg cccgatcgtg aagcagttag     2700

agagaggcgg gagagccgtg gtgaagatgg actggcggga gaacatcact gtccccctcc     2760

agacagacct gcgtaaattc aggacctata aaggtggttc tgtcagagat ctcctccgag     2820

ccatgagaaa taagaagcac cactaccggg agctgcctgc agaggtgcgg gagacgctgg     2880

ggtccctccc cgacgacttc gtgtgctact tcacatctcg cttcccccac ctcctcgcac     2940

acacctaccg ggccatggag ctgtgcagcc acgagagact cttccagccc tactacttcc     3000

acgagccccc agagccccag cccccagtga ctccagacgc cctctgagcg agggcggccc     3060

ctctgttctg gtggccccag ctgtgactga gggcctggtc accacaatta gagcttgatg     3120

cctcccggct ttgcagggag accaggcttc ccaaaccaag tgccttgagc tgcctgctct     3180

gcagcccaca gaggacagtg ctgaccccag gaagtgggag aagtggcccc tcgtgaccta     3240

cagggaactg ggaagatgct ggccccaaaa gccttacggt catgatgtct gcaaaggagg     3300

gcctcagaga cagcgcgagt agcaccccca gccatctact ggataaactt gcttcagact     3360

ttttaaattc ctgcttaatg tcagtctaca ggcctttcag gaagggagag gagggaatcg     3420

tacattttgc ttgcgtgctg ggacagctag gctgagatgc accaagtaca gccttcactg     3480

gagaccggaa ttgagaggtg ggggatgctg aggaggggga ggacggagtt cagagggtgt     3540

cgtcctgcag tgtgagattt ctcattgatc acagatgtgc ccagagtagc ccaggtcact     3600

gttaactagt gtttctgcag aggcagcagg agccatgagc atgaggtgtg gcattaggga     3660

ctggtcagct atgcatgctg gcaggtgggg ttgtgtctgc aggtctcaga aatgaagagg     3720

ctgctctgtt ctggaggcag ccgtggccca gtgccagtgg ccagaacagt ggcctttggt     3780

gggtgtgtcc cgggccatct cggggtggtg ctcaggagcg cctggggcaa gaggtaaaga     3840

gttccctggc cttcaaggag agcagcgaag acccagacag gggccagcct tcaggaccag     3900

agggaggccg ccgaatggga ccctcctggt caccaggaga aagccctggg ccagcgagta     3960

ggcagtcaaa ctccttcgtc cccaaggccg gtggaacaag aggct                     4005


<210>  15
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  16
<211>  4665
<212>  DNA
<213>  Homo sapiens

<400>  16
ggaaagtcca ccttccccaa caaggccagc ctgggaacat ggagtggcag cggccgcagc       60

caatgagaga gcaaacgcgc ggaaagtttg ctcaatgggc gatgtccgag ataggctgtc      120

actcaggtgg cagcggcaga ggccgggctg agacgtggcc aggggaacac ggctggctgt      180

ccaggccgtc ggggcggcag tagggtccct agcacgtcct tgccttcttg ggagctccaa      240

gcggcgggag aggcaggcgt cagtggctgc gcctccatgc ctgcgcgcgg ggcgggacgc      300

tgatggagcg cgccatcagc ccggggctgc tggtacgggc gctgctgctg ctgctgctgc      360

tgctggggct cgcggcaagg acggtggccg cggggcgcgc ccgtggcctc ccagcgccga      420

cggcggaggc ggcgttcggc ctcggggcgg ccgctgctcc cacctcagcg acgcgagtac      480

cggcggcggg cgccgtggct gcggccgagg tgactgtgga ggacgctgag gcgctgccgg      540

cagccgcggg agagcaggag cctcggggtc cggaaccaga cgatgagaca gagttgcgac      600

cgcgcggcag gtcattagta attatcagca ctttagatgg gagaattgct gccttggatc      660

ctgaaaatca tggtaaaaag cagtgggatt tggatgtggg atccggttcc ttggtgtcat      720

ccagccttag caaaccagag gtatttggga ataagatgat cattccttcc ctggatggag      780

ccctcttcca gtgggaccaa gaccgtgaaa gcatggaaac agttcctttc acagttgaat      840

cacttcttga atcttcttat aaatttggag atgatgttgt tttggttgga ggaaaatctc      900

tgactacata tggactcagt gcatatagtg gaaaggtgag gtatatctgt tcagctctgg      960

gttgtcgcca atgggatagt gacgaaatgg aacaagagga agacatcctg cttctacagc     1020

gtacccaaaa aactgttaga gctgtcggac ctcgcagtgg caatgagaag tggaatttca     1080

gtgttggcca ctttgaactt cggtatattc cagacatgga aacgagagcc ggatttattg     1140

aaagcacctt taagcccaat gagaacacag aagagtctaa aattatttca gatgtggaag     1200

aacaggaagc tgccataatg gacatagtga taaaggtttc ggttgctgac tggaaagtta     1260

tggcattcag taagaaggga ggacatctgg aatgggagta ccagttttgt actccaattg     1320

catctgcctg gttacttaag gatgggaaag tcattcccat cagtcttttt gatgatacaa     1380

gttatacatc taatgatgat gttttagaag atgaagaaga cattgtagaa gctgccagag     1440

gagccacaga aaacagtgtt tacttgggaa tgtatagagg ccagctgtat ctgcagtcat     1500

cagtcagaat ttcagaaaag tttccttcaa gtcccaaggc tttggaatct gtcactaatg     1560

aaaacgcaat tattccttta ccaacaatca aatggaaacc cttaattcat tctccttcca     1620

gaactcctgt cttggtagga tctgatgaat ttgacaaatg tctcagtaat gataagtttt     1680

ctcatgaaga atatagtaat ggtgcacttt caatcttgca gtatccatat gataatggtt     1740

attatctacc atactacaag agggagagga acaaacgaag cacacagatt acagtcagat     1800

tcctcgacaa cccacattac aacaagaata tccgcaaaaa ggatcctgtt cttcttttac     1860

actggtggaa agaaatagtt gcaacgattt tgttttgtat catagcaaca acgtttattg     1920

tgcgcaggct tttccatcct catcctcaca ggcaaaggaa ggagtctgaa actcagtgtc     1980

aaactgaaaa taaatatgat tctgtaagtg gtgaagccaa tgacagtagc tggaatgaca     2040

taaaaaactc tggatatata tcacgatatc taactgattt tgagccaatt caatgcctgg     2100

gacgtggtgg ctttggagtt gtttttgaag ctaaaaacaa agtagatgac tgcaattatg     2160

ctatcaagag gatccgtctc cccaataggg aattggctcg ggaaaaggta atgcgagaag     2220

ttaaagcctt agccaagctt gaacacccgg gcattgttag atatttcaat gcctggctcg     2280

aagcaccacc agagaagtgg caagaaaaga tggatgaaat ttggctgaaa gatgaaagca     2340

cagactggcc actcagctct cctagcccaa tggatgcacc atcagttaaa atacgcagaa     2400

tggatccttt cgctacaaaa gaacatattg aaatcatagc tccttcacca caaagaagca     2460

ggtctttttc agtagggatt tcctgtgacc agacaagttc atctgagagc cagttctcac     2520

cactggaatt ctcaggaatg gaccatgagg acatcagtga gtcagtggat gcagcataca     2580

acctccagga cagttgcctt acagactgtg atgtggaaga tgggactatg gatggcaatg     2640

atgaggggca ctcctttgaa ctttgtcctt ctgaagcttc tccttatgta aggtcaaggg     2700

agagaacctc ctcttcaata gtatttgaag attctggctg tgataatgct tccagtaaag     2760

aagagccgaa aactaatcga ttgcatattg gcaaccattg tgctaataaa ctaactgctt     2820

tcaagcccac cagtagcaaa tcttcttctg aagctacatt gtctatttct cctccaagac     2880

caaccacttt aagtttagat ctcactaaaa acaccacaga aaaactccag cccagttcac     2940

caaaggtgta tctttacatt caaatgcagc tgtgcagaaa agaaaacctc aaagactgga     3000

tgaatggacg atgtaccata gaggagagag agaggagcgt gtgtctgcac atcttcctgc     3060

agatcgcaga ggcagtggag tttcttcaca gtaaaggact gatgcacagg gacctcaagc     3120

catccaacat attctttaca atggatgatg tggtcaaggt tggagacttt gggttagtga     3180

ctgcaatgga ccaggatgag gaagagcaga cggttctgac cccaatgcca gcttatgcca     3240

gacacacagg acaagtaggg accaaactgt atatgagccc agagcagatt catggaaaca     3300

gctattctca taaagtggac atcttttctt taggcctgat tctatttgaa ttgctgtatc     3360

cattcagcac tcagatggag agagtcagga ccttaactga tgtaagaaat ctcaaatttc     3420

caccattatt tactcagaaa tatccttgtg agtacgtgat ggttcaagac atgctctctc     3480

catcccccat ggaacgacct gaagctataa acatcattga aaatgctgta tttgaggact     3540

tggactttcc aggaaaaaca gtgctcagac agaggtctcg ctccttgagt tcatcgggaa     3600

caaaacattc aagacagtcc aacaactccc atagcccttt gccaagcaat tagccttaag     3660

ttgtgctagc aaccctaata ggtgatgcag ataatagcct acttcttaga atatgcctgt     3720

ccaaaattgc agacttgaaa agtttgttct tcgctcaatt tttttgtgga ctactttttt     3780

tatatcaaat ttaagctgga tttgggggca taacctaatt tgagccaact cctgagtttt     3840

gctatactta aggaaagggc tatctttgtt ctttgttagt ctcttgaaac tggctgctgg     3900

ccaagcttta tagccctcac catttgccta aggaggtagc agcaatccct aatatatata     3960

tatagtgaga actaaaatgg atatattttt ataatgcaga agaaggaaag tccccctgtg     4020

tggtaactgt attgttctag aaatatgctt tctagagata tgatgatttt gaaactgatt     4080

tctagaaaaa gctgactcca tttttgtccc tggcgggtaa attaggaatc tgcactattt     4140

tggaggacaa gtagcacaaa ctgtataacg gtttatgtcc gtagttttat agtcctattt     4200

gtagcattca atagctttat tccttagatg gttctagggt gggtttacag ctttttgtac     4260

ttttacctcc aataaaggga aaatgaagct ttttatgtaa attggttgaa aggtctagtt     4320

ttgggaggaa aaaagccgta gtaagaaatg gatcatatat attacaacta acttcttcaa     4380

ctatggactt tttaagccta atgaaatctt aagtgtctta tatgtaatcc tgtaggttgg     4440

tacttccccc aaactgatta taggtaacag tttaatcatc tcacttgcta acatgttttt     4500

atttttcact gtaaatatgt ttatgtttta tttataaaaa ttctgaaatc aatccatttg     4560

ggttggtggt gtacagaaca cacttaagtg tgttaacttg tgacttcttt caagtctaaa     4620

tgatttaata aaactttttt taaattaaaa aaaaaaaaaa aaaaa                     4665


<210>  17
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg 
            20                  25                  30          


Ala Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly 
        35                  40                  45              


Ala Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala 
    50                  55                  60                  


Val Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala 
65                  70                  75                  80  


Ala Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr 
                85                  90                  95      


Glu Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp 
            100                 105                 110         


Gly Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp 
        115                 120                 125             


Asp Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys 
    130                 135                 140                 


Pro Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala 
145                 150                 155                 160 


Leu Phe Gln Trp Asp Gln Asp Arg Glu Ser Met Glu Thr Val Pro Phe 
                165                 170                 175     


Thr Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val 
            180                 185                 190         


Val Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr 
        195                 200                 205             


Ser Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp 
    210                 215                 220                 


Asp Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg 
225                 230                 235                 240 


Thr Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys 
                245                 250                 255     


Trp Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met 
            260                 265                 270         


Glu Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn 
        275                 280                 285             


Thr Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala 
    290                 295                 300                 


Ile Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met 
305                 310                 315                 320 


Ala Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys 
                325                 330                 335     


Thr Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro 
            340                 345                 350         


Ile Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu 
        355                 360                 365             


Glu Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn 
    370                 375                 380                 


Ser Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser 
385                 390                 395                 400 


Val Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser 
                405                 410                 415     


Val Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys 
            420                 425                 430         


Pro Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp 
        435                 440                 445             


Glu Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr 
    450                 455                 460                 


Ser Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr 
465                 470                 475                 480 


Tyr Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile 
                485                 490                 495     


Thr Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys 
            500                 505                 510         


Lys Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr 
        515                 520                 525             


Ile Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe 
    530                 535                 540                 


His Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln 
545                 550                 555                 560 


Thr Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser 
                565                 570                 575     


Trp Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp 
            580                 585                 590         


Phe Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe 
        595                 600                 605             


Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile 
    610                 615                 620                 


Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val 
625                 630                 635                 640 


Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn 
                645                 650                 655     


Ala Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu 
            660                 665                 670         


Ile Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser 
        675                 680                 685             


Pro Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ala 
    690                 695                 700                 


Thr Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg 
705                 710                 715                 720 


Ser Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser 
                725                 730                 735     


Gln Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser 
            740                 745                 750         


Glu Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp 
        755                 760                 765             


Cys Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser 
    770                 775                 780                 


Phe Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu 
785                 790                 795                 800 


Arg Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala 
                805                 810                 815     


Ser Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His 
            820                 825                 830         


Cys Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser 
        835                 840                 845             


Ser Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser 
    850                 855                 860                 


Leu Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro 
865                 870                 875                 880 


Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu 
                885                 890                 895     


Lys Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser 
            900                 905                 910         


Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu 
        915                 920                 925             


His Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe 
    930                 935                 940                 


Phe Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr 
945                 950                 955                 960 


Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro 
                965                 970                 975     


Ala Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser 
            980                 985                 990         


Pro Glu Gln Ile His Gly Asn Ser  Tyr Ser His Lys Val  Asp Ile Phe 
        995                 1000                 1005             


Ser Leu  Gly Leu Ile Leu Phe  Glu Leu Leu Tyr Pro  Phe Ser Thr 
    1010                 1015                 1020             


Gln Met  Glu Arg Val Arg Thr  Leu Thr Asp Val Arg  Asn Leu Lys 
    1025                 1030                 1035             


Phe Pro  Pro Leu Phe Thr Gln  Lys Tyr Pro Cys Glu  Tyr Val Met 
    1040                 1045                 1050             


Val Gln  Asp Met Leu Ser Pro  Ser Pro Met Glu Arg  Pro Glu Ala 
    1055                 1060                 1065             


Ile Asn  Ile Ile Glu Asn Ala  Val Phe Glu Asp Leu  Asp Phe Pro 
    1070                 1075                 1080             


Gly Lys  Thr Val Leu Arg Gln  Arg Ser Arg Ser Leu  Ser Ser Ser 
    1085                 1090                 1095             


Gly Thr  Lys His Ser Arg Gln  Ser Asn Asn Ser His  Ser Pro Leu 
    1100                 1105                 1110             


Pro Ser  Asn 
    1115     


