
                                SEQUENCE LISTING

<110> Malek, Thomas

<120> INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR
  ALPHA FUSION PROTEINS AND METHODS OF USE
  
  

<130> 060569-464173

<150> US 62/033,726       
<151> 2014-08-06  

<160> 65

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 153
<212> PRT
<213> Homo sapeins

<400> 1
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr
145                 150             


<210> 2
<211> 133
<212> PRT
<213> Homo sapiens

<400> 2
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr
    130             


<210> 3
<211> 169
<212> PRT
<213> Mus musculus

<400> 3
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln
                165                 


<210> 4
<211> 169
<212> PRT
<213> Mus musculus

<400> 4
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln
                165                 


<210> 5
<211> 272
<212> PRT
<213> Homo sapiens

<400> 5
Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val
 1               5                  10                  15      
Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro
            20                  25                  30          
His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn
        35                  40                  45              
Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr
    50                  55                  60                  
Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys
65                  70                  75                  80  
Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro
                85                  90                  95      
Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro
            100                 105                 110         
Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro
        115                 120                 125             
Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val
    130                 135                 140                 
Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His
145                 150                 155                 160 
Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg
                165                 170                 175     
Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln
            180                 185                 190         
Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu
        195                 200                 205             
Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr
    210                 215                 220                 
Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
225                 230                 235                 240 
Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu
                245                 250                 255     
Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile
            260                 265                 270         


<210> 6
<211> 251
<212> PRT
<213> Homo sapiens

<400> 6
Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys
 1               5                  10                  15      
Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg
            20                  25                  30          
Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly
        35                  40                  45              
Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser
    50                  55                  60                  
Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln
65                  70                  75                  80  
Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp
                85                  90                  95      
Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn
            100                 105                 110         
Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr
        115                 120                 125             
Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu
    130                 135                 140                 
Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln
145                 150                 155                 160 
Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu
                165                 170                 175     
Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys
            180                 185                 190         
Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr
        195                 200                 205             
Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly
    210                 215                 220                 
Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp
225                 230                 235                 240 
Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile
                245                 250     


<210> 7
<211> 219
<212> PRT
<213> Homo sapiens

<400> 7
Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys
 1               5                  10                  15      
Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg
            20                  25                  30          
Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly
        35                  40                  45              
Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser
    50                  55                  60                  
Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln
65                  70                  75                  80  
Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp
                85                  90                  95      
Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn
            100                 105                 110         
Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr
        115                 120                 125             
Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu
    130                 135                 140                 
Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln
145                 150                 155                 160 
Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu
                165                 170                 175     
Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys
            180                 185                 190         
Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr
        195                 200                 205             
Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
    210                 215                 


<210> 8
<211> 268
<212> PRT
<213> Mus musculus

<400> 8
Met Glu Pro Arg Leu Leu Met Leu Gly Phe Leu Ser Leu Thr Ile Val
 1               5                  10                  15      
Pro Ser Cys Arg Ala Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro
            20                  25                  30          
Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn
        35                  40                  45              
Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met
    50                  55                  60                  
Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn
65                  70                  75                  80  
Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln
                85                  90                  95      
Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met
            100                 105                 110         
His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys
        115                 120                 125             
His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val
    130                 135                 140                 
His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala
145                 150                 155                 160 
Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro
                165                 170                 175     
Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser
            180                 185                 190         
Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser
        195                 200                 205             
Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala
    210                 215                 220                 
Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys Val Ala Val Ala
225                 230                 235                 240 
Ser Cys Leu Phe Leu Leu Ile Ser Ile Leu Leu Leu Ser Gly Leu Thr
                245                 250                 255     
Trp Gln His Arg Trp Arg Lys Ser Arg Arg Thr Ile
            260                 265             


<210> 9
<211> 247
<212> PRT
<213> Mus musculus

<400> 9
Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys
 1               5                  10                  15      
Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg
            20                  25                  30          
Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn
        35                  40                  45              
Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser
    50                  55                  60                  
Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr
65                  70                  75                  80  
Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu
                85                  90                  95      
Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys
            100                 105                 110         
Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile
        115                 120                 125             
Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys
    130                 135                 140                 
Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val
145                 150                 155                 160 
Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly
                165                 170                 175     
Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr
            180                 185                 190         
Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe
        195                 200                 205             
Val Leu Thr Met Glu Tyr Lys Val Ala Val Ala Ser Cys Leu Phe Leu
    210                 215                 220                 
Leu Ile Ser Ile Leu Leu Leu Ser Gly Leu Thr Trp Gln His Arg Trp
225                 230                 235                 240 
Arg Lys Ser Arg Arg Thr Ile
                245         


<210> 10
<211> 215
<212> PRT
<213> Mus musculus

<400> 10
Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys
 1               5                  10                  15      
Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg
            20                  25                  30          
Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn
        35                  40                  45              
Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser
    50                  55                  60                  
Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr
65                  70                  75                  80  
Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu
                85                  90                  95      
Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys
            100                 105                 110         
Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile
        115                 120                 125             
Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys
    130                 135                 140                 
Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val
145                 150                 155                 160 
Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly
                165                 170                 175     
Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr
            180                 185                 190         
Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe
        195                 200                 205             
Val Leu Thr Met Glu Tyr Lys
    210                 215 


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly3Ser)4 linker

<400> 11
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10                  15      


<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly3Ser)2 linker

<400> 12
Gly Gly Gly Ser Gly Gly Gly Ser
 1               5              


<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly3Ser)3 linker

<400> 13
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10          


<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly3Ser)5 linker

<400> 14
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 15
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Gly3 linker

<400> 15
Gly Gly Gly
 1          


<210> 16
<211> 384
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized Mature form of IL-2
      (Gly4Ser)4-extracellular domain of IL-2 R

<400> 16
Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln
 1               5                  10                  15      
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu
            20                  25                  30          
Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu
        35                  40                  45              
Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala
    50                  55                  60                  
Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu
65                  70                  75                  80  
Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp
                85                  90                  95      
Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys
            100                 105                 110         
Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr
        115                 120                 125             
Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile
    130                 135                 140                 
Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro
                165                 170                 175     
Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly
            180                 185                 190         
Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu
        195                 200                 205             
Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln
    210                 215                 220                 
Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln
225                 230                 235                 240 
Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro
                245                 250                 255     
Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro
            260                 265                 270         
Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu
        275                 280                 285             
Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln
    290                 295                 300                 
Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly
305                 310                 315                 320 
Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg
                325                 330                 335     
Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu
            340                 345                 350         
Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr
        355                 360                 365             
Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys
    370                 375                 380                 


<210> 17
<211> 404
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2
      (Gly4Ser)4-extracellular domain of IL-2 R

<400> 17
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly
                165                 170                 175     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys
            180                 185                 190         
Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser
        195                 200                 205             
Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg
    210                 215                 220                 
Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser
225                 230                 235                 240 
Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln
                245                 250                 255     
Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp
            260                 265                 270         
Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His
        275                 280                 285             
Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr
    290                 295                 300                 
His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr
305                 310                 315                 320 
Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys
                325                 330                 335     
Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg
            340                 345                 350         
Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn
        355                 360                 365             
Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe
    370                 375                 380                 
Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr
385                 390                 395                 400 
Met Glu Tyr Lys
                


<210> 18
<211> 389
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form of IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R

<400> 18
Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln
 1               5                  10                  15      
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu
            20                  25                  30          
Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu
        35                  40                  45              
Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala
    50                  55                  60                  
Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu
65                  70                  75                  80  
Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp
                85                  90                  95      
Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys
            100                 105                 110         
Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr
        115                 120                 125             
Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile
    130                 135                 140                 
Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
                165                 170                 175     
Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu
            180                 185                 190         
Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe
        195                 200                 205             
Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp
    210                 215                 220                 
Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys
225                 230                 235                 240 
Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr
                245                 250                 255     
Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly
            260                 265                 270         
His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile
        275                 280                 285             
Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly
    290                 295                 300                 
Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys
305                 310                 315                 320 
Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu
                325                 330                 335     
Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg
            340                 345                 350         
Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp
        355                 360                 365             
Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu
    370                 375                 380                 
Thr Met Glu Tyr Lys
385                 


<210> 19
<211> 409
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R

<400> 19
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly
                165                 170                 175     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            180                 185                 190         
Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr
        195                 200                 205             
Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys
    210                 215                 220                 
Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu
225                 230                 235                 240 
Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp
                245                 250                 255     
Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln
            260                 265                 270         
Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu
        275                 280                 285             
Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp
    290                 295                 300                 
Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu
305                 310                 315                 320 
Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile
                325                 330                 335     
Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr
            340                 345                 350         
Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser
        355                 360                 365             
Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile
    370                 375                 380                 
Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu
385                 390                 395                 400 
Thr Phe Val Leu Thr Met Glu Tyr Lys
                405                 


<210> 20
<211> 380
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form of IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R

<400> 20
Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln
 1               5                  10                  15      
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu
            20                  25                  30          
Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu
        35                  40                  45              
Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala
    50                  55                  60                  
Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu
65                  70                  75                  80  
Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp
                85                  90                  95      
Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys
            100                 105                 110         
Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr
        115                 120                 125             
Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile
    130                 135                 140                 
Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro
                165                 170                 175     
Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn
            180                 185                 190         
Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met
        195                 200                 205             
Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn
    210                 215                 220                 
Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln
225                 230                 235                 240 
Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met
                245                 250                 255     
His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys
            260                 265                 270         
His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val
        275                 280                 285             
His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala
    290                 295                 300                 
Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro
305                 310                 315                 320 
Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser
                325                 330                 335     
Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser
            340                 345                 350         
Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala
        355                 360                 365             
Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys
    370                 375                 380 


<210> 21
<211> 400
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R

<400> 21
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly
                165                 170                 175     
Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro
            180                 185                 190         
Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly
        195                 200                 205             
Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu
    210                 215                 220                 
Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln
225                 230                 235                 240 
Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln
                245                 250                 255     
Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro
            260                 265                 270         
Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro
        275                 280                 285             
Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu
    290                 295                 300                 
Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln
305                 310                 315                 320 
Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly
                325                 330                 335     
Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg
            340                 345                 350         
Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu
        355                 360                 365             
Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr
    370                 375                 380                 
Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys
385                 390                 395                 400 


<210> 22
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly4Ser)4-
      extracellular domain of IL-2 R

<400> 22
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro
145                 150                 155                 160 
Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly
                165                 170                 175     
Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser
            180                 185                 190         
Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp
        195                 200                 205             
Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys
    210                 215                 220                 
Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu
225                 230                 235                 240 
Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His
                245                 250                 255     
Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr
            260                 265                 270         
His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr
        275                 280                 285             
Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His
    290                 295                 300                 
Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met
305                 310                 315                 320 
Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu
                325                 330                 335     
Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe
            340                 345                 350         
Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr
        355                 360                 365             
Thr Glu Tyr Gln
    370         


<210> 23
<211> 392
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly4Ser)4-
      extracellular domain of IL-2 R

<400> 23
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys
                165                 170                 175     
Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala
            180                 185                 190         
Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg
        195                 200                 205             
Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser
    210                 215                 220                 
His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg
225                 230                 235                 240 
Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg
                245                 250                 255     
Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser
            260                 265                 270         
Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr
        275                 280                 285             
Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys
    290                 295                 300                 
Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys
305                 310                 315                 320 
Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys
                325                 330                 335     
Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln
            340                 345                 350         
Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr
        355                 360                 365             
Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr
    370                 375                 380                 
Ser Ile Phe Thr Thr Glu Tyr Gln
385                 390         


<210> 24
<211> 368
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R

<400> 24
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly
    130                 135                 140                 
Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro
145                 150                 155                 160 
His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn
                165                 170                 175     
Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr
            180                 185                 190         
Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys
        195                 200                 205             
Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro
    210                 215                 220                 
Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro
225                 230                 235                 240 
Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro
                245                 250                 255     
Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val
            260                 265                 270         
Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His
        275                 280                 285             
Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg
    290                 295                 300                 
Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln
305                 310                 315                 320 
Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu
                325                 330                 335     
Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr
            340                 345                 350         
Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
        355                 360                 365             


<210> 25
<211> 388
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R

<400> 25
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro
                165                 170                 175     
Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly
            180                 185                 190         
Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser
        195                 200                 205             
Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp
    210                 215                 220                 
Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys
225                 230                 235                 240 
Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu
                245                 250                 255     
Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His
            260                 265                 270         
Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr
        275                 280                 285             
His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr
    290                 295                 300                 
Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His
305                 310                 315                 320 
Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met
                325                 330                 335     
Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu
            340                 345                 350         
Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe
        355                 360                 365             
Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr
    370                 375                 380                 
Thr Glu Tyr Gln
385             


<210> 26
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R

<400> 26
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly
    130                 135                 140                 
Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe
145                 150                 155                 160 
Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys
                165                 170                 175     
Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr
            180                 185                 190         
Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser
        195                 200                 205             
Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu
    210                 215                 220                 
Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val
225                 230                 235                 240 
Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu
                245                 250                 255     
Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val
            260                 265                 270         
Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala
        275                 280                 285             
Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro
    290                 295                 300                 
Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu
305                 310                 315                 320 
Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser
                325                 330                 335     
Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala
            340                 345                 350         
Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
        355                 360                 


<210> 27
<211> 384
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R

<400> 27
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro
                165                 170                 175     
His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn
            180                 185                 190         
Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr
        195                 200                 205             
Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys
    210                 215                 220                 
Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro
225                 230                 235                 240 
Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro
                245                 250                 255     
Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro
            260                 265                 270         
Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val
        275                 280                 285             
Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His
    290                 295                 300                 
Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg
305                 310                 315                 320 
Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln
                325                 330                 335     
Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu
            340                 345                 350         
Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr
        355                 360                 365             
Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
    370                 375                 380                 


<210> 28
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-2 leader optimized Kozak sequence

<400> 28
gccaccatgg acaggatgca actcctgtct tgcattgcac taagtcttgc acttgtcaca 60
aacagt                                                            66

<210> 29
<211> 1239
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2
      (Gly4Ser)4-extracellular domain of IL-2 R

<400> 29
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc 60
gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag 120
cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg 180
atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc 240
aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg 300
catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc 360
agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa 420
ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa 480
agcatcatct caacaagccc tcaaggtgga ggtggatctg gtggaggtgg atcaggtgga 540
ggtggatccg gtggaggtgg atctgaactg tgtctgtatg acccacccga ggtccccaat 600
gccacattca aagccctctc ctacaagaac ggcaccatcc taaactgtga atgcaagaga 660
ggtttccgaa gactaaagga attggtctat atgcgttgct taggaaactc ctggagcagc 720
aactgccagt gcaccagcaa ctcccatgac aaatcgagaa agcaagttac agctcaactt 780
gaacaccaga aagagcaaca aaccacaaca gacatgcaga agccaacaca gtctatgcac 840
caagagaacc ttacaggtca ctgcagggag ccacctcctt ggaaacatga agattccaag 900
agaatctatc atttcgtgga aggacagagt gttcactacg agtgtattcc gggatacaag 960
gctctacaga gaggtcctgc tattagcatc tgcaagatga agtgtgggaa aacggggtgg 1020
actcagcccc agctcacatg tgtagatgaa agagaacacc accgatttct ggctagtgag 1080
gaatctcaag gaagcagaaa ttcttctccc gagagtgaga cttcctgccc cataaccacc 1140
acagacttcc cacaacccac agaaacaact gcaatgacgg agacatttgt gctcacaatg 1200
gagtataagg gtggacatca ccatcaccat cactaataa                        1239

<210> 30
<211> 1227
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R

<400> 30
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc 60
gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag 120
cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg 180
atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc 240
aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg 300
catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc 360
agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa 420
ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa 480
agcatcatct caacaagccc tcaaggtgga ggttctggtg gaggttcagg tggaggttcg 540
ggtggaggtt ctgaactgtg tctgtatgac ccacccgagg tccccaatgc cacattcaaa 600
gccctctcct acaagaacgg caccatccta aactgtgaat gcaagagagg tttccgaaga 660
ctaaaggaat tggtctatat gcgttgctta ggaaactcct ggagcagcaa ctgccagtgc 720
accagcaact cccatgacaa atcgagaaag caagttacag ctcaacttga acaccagaaa 780
gagcaacaaa ccacaacaga catgcagaag ccaacacagt ctatgcacca agagaacctt 840
acaggtcact gcagggagcc acctccttgg aaacatgaag attccaagag aatctatcat 900
ttcgtggaag gacagagtgt tcactacgag tgtattccgg gatacaaggc tctacagaga 960
ggtcctgcta ttagcatctg caagatgaag tgtgggaaaa cggggtggac tcagccccag 1020
ctcacatgtg tagatgaaag agaacaccac cgatttctgg ctagtgagga atctcaagga 1080
agcagaaatt cttctcccga gagtgagact tcctgcccca taaccaccac agacttccca 1140
caacccacag aaacaactgc aatgacggag acatttgtgc tcacaatgga gtataagggt 1200
ggacatcacc atcaccatca ctaataa                                     1227

<210> 31
<211> 1254
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R

<400> 31
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc 60
gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag 120
cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg 180
atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc 240
aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg 300
catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc 360
agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa 420
ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa 480
agcatcatct caacaagccc tcaaggtgga ggtggatcag gtggaggtgg atctggtgga 540
ggtggatcag gtggaggtgg atccggtgga ggtggatctg aactgtgtct gtatgaccca 600
cccgaggtcc ccaatgccac attcaaagcc ctctcctaca agaacggcac catcctaaac 660
tgtgaatgca agagaggttt ccgaagacta aaggaattgg tctatatgcg ttgcttagga 720
aactcctgga gcagcaactg ccagtgcacc agcaactccc atgacaaatc gagaaagcaa 780
gttacagctc aacttgaaca ccagaaagag caacaaacca caacagacat gcagaagcca 840
acacagtcta tgcaccaaga gaaccttaca ggtcactgca gggagccacc tccttggaaa 900
catgaagatt ccaagagaat ctatcatttc gtggaaggac agagtgttca ctacgagtgt 960
attccgggat acaaggctct acagagaggt cctgctatta gcatctgcaa gatgaagtgt 1020
gggaaaacgg ggtggactca gccccagctc acatgtgtag atgaaagaga acaccaccga 1080
tttctggcta gtgaggaatc tcaaggaagc agaaattctt ctcccgagag tgagacttcc 1140
tgccccataa ccaccacaga cttcccacaa cccacagaaa caactgcaat gacggagaca 1200
tttgtgctca caatggagta taagggtgga catcaccatc accatcacta ataa       1254

<210> 32
<211> 1206
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly4Ser)4-
      extracellular domain of IL-2 R

<400> 32
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggtgg atctggtgga 480
ggtggatcag gtggaggtgg atccggtgga ggtggatctg agctctgtga cgatgacccg 540
ccagagatcc cacacgccac attcaaagcc atggcctaca aggaaggaac catgttgaac 600
tgtgaatgca agagaggttt ccgcagaata aaaagcgggt cactctatat gctctgtaca 660
ggaaactcta gccactcgtc ctgggacaac caatgtcaat gcacaagctc tgccactcgg 720
aacacaacga aacaagtgac acctcaacct gaagaacaga aagaaaggaa aaccacagaa 780
atgcaaagtc caatgcagcc agtggaccaa gcgagccttc caggtcactg cagggaacct 840
ccaccatggg aaaatgaagc cacagagaga atttatcatt tcgtggtggg gcagatggtt 900
tattatcagt gcgtccaggg atacagggct ctacacagag gtcctgctga gagcgtctgc 960
aaaatgaccc acgggaagac aaggtggacc cagccccagc tcatatgcac aggtgaaatg 1020
gagaccagtc agtttccagg tgaagagaag cctcaggcaa gccccgaagg ccgtcctgag 1080
agtgagactt cctgcctcgt cacaacaaca gattttcaaa tacagacaga aatggctgca 1140
accatggaga cgtccatatt tacaacagag taccagggtg gacatcacca tcaccatcac 1200
taataa                                                            1206

<210> 33
<211> 1194
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R

<400> 33
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt 480
tcaggtggag gttcgggtgg aggttctgag ctctgtgacg atgacccgcc agagatccca 540
cacgccacat tcaaagccat ggcctacaag gaaggaacca tgttgaactg tgaatgcaag 600
agaggtttcc gcagaataaa aagcgggtca ctctatatgc tctgtacagg aaactctagc 660
cactcgtcct gggacaacca atgtcaatgc acaagctctg ccactcggaa cacaacgaaa 720
caagtgacac ctcaacctga agaacagaaa gaaaggaaaa ccacagaaat gcaaagtcca 780
atgcagccag tggaccaagc gagccttcca ggtcactgca gggaacctcc accatgggaa 840
aatgaagcca cagagagaat ttatcatttc gtggtggggc agatggttta ttatcagtgc 900
gtccagggat acagggctct acacagaggt cctgctgaga gcgtctgcaa aatgacccac 960
gggaagacaa ggtggaccca gccccagctc atatgcacag gtgaaatgga gaccagtcag 1020
tttccaggtg aagagaagcc tcaggcaagc cccgaaggcc gtcctgagag tgagacttcc 1080
tgcctcgtca caacaacaga ttttcaaata cagacagaaa tggctgcaac catggagacg 1140
tccatattta caacagagta ccagggtgga catcaccatc accatcacta ataa       1194

<210> 34
<211> 1182
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R

<400> 34
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt 480
tcaggtggag gttcggagct ctgtgacgat gacccgccag agatcccaca cgccacattc 540
aaagccatgg cctacaagga aggaaccatg ttgaactgtg aatgcaagag aggtttccgc 600
agaataaaaa gcgggtcact ctatatgctc tgtacaggaa actctagcca ctcgtcctgg 660
gacaaccaat gtcaatgcac aagctctgcc actcggaaca caacgaaaca agtgacacct 720
caacctgaag aacagaaaga aaggaaaacc acagaaatgc aaagtccaat gcagccagtg 780
gaccaagcga gccttccagg tcactgcagg gaacctccac catgggaaaa tgaagccaca 840
gagagaattt atcatttcgt ggtggggcag atggtttatt atcagtgcgt ccagggatac 900
agggctctac acagaggtcc tgctgagagc gtctgcaaaa tgacccacgg gaagacaagg 960
tggacccagc cccagctcat atgcacaggt gaaatggaga ccagtcagtt tccaggtgaa 1020
gagaagcctc aggcaagccc cgaaggccgt cctgagagtg agacttcctg cctcgtcaca 1080
acaacagatt ttcaaataca gacagaaatg gctgcaacca tggagacgtc catatttaca 1140
acagagtacc agggtggaca tcaccatcac catcactaat aa                    1182

<210> 35
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> Kozak consensus

<400> 35
gccgccrcca ugg                                                    13

<210> 36
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R

<400> 36
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly
                165                 170                 175     
Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro
            180                 185                 190         
Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn
        195                 200                 205             
Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met
    210                 215                 220                 
Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn
225                 230                 235                 240 
Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln
                245                 250                 255     
Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met
            260                 265                 270         
His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys
        275                 280                 285             
His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val
    290                 295                 300                 
His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala
305                 310                 315                 320 
Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro
                325                 330                 335     
Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser
            340                 345                 350         
Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser
        355                 360                 365             
Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala
    370                 375                 380                 
Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys
385                 390                 395     


<210> 37
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form of IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R

<400> 37
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly
                165                 170                 175     
Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro
            180                 185                 190         
Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn
        195                 200                 205             
Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met
    210                 215                 220                 
Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn
225                 230                 235                 240 
Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln
                245                 250                 255     
Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met
            260                 265                 270         
His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys
        275                 280                 285             
His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val
    290                 295                 300                 
His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala
305                 310                 315                 320 
Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro
                325                 330                 335     
Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser
            340                 345                 350         
Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser
        355                 360                 365             
Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala
    370                 375                 380                 
Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys
385                 390                 395     


<210> 38
<211> 397
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R

<400> 38
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
                165                 170                 175     
Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr
            180                 185                 190         
Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys
        195                 200                 205             
Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys
    210                 215                 220                 
Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr
225                 230                 235                 240 
Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu
                245                 250                 255     
Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro
            260                 265                 270         
Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp
        275                 280                 285             
Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met
    290                 295                 300                 
Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro
305                 310                 315                 320 
Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln
                325                 330                 335     
Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly
            340                 345                 350         
Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr
        355                 360                 365             
Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala
    370                 375                 380                 
Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
385                 390                 395         


<210> 39
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form of human IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R

<400> 39
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
145                 150                 155                 160 
Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met
                165                 170                 175     
Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe
            180                 185                 190         
Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser
        195                 200                 205             
Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr
    210                 215                 220                 
Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu
225                 230                 235                 240 
Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala
                245                 250                 255     
Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala
            260                 265                 270         
Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln
        275                 280                 285             
Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val
    290                 295                 300                 
Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile
305                 310                 315                 320 
Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro
                325                 330                 335     
Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val
            340                 345                 350         
Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu
        355                 360                 365             
Thr Ser Ile Phe Thr Thr Glu Tyr Gln
    370                 375         


<210> 40
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence (Gly4Ser)4

<400> 40
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 41
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence (Gly4Ser)5

<400> 41
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser
            20                  25  


<210> 42
<211> 1215
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R

<400> 42
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc 60
gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag 120
cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg 180
atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc 240
aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg 300
catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc 360
agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa 420
ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa 480
agcatcatct caacaagccc tcaaggtgga ggttctggtg gaggttcagg tggaggttcg 540
gaactgtgtc tgtatgaccc acccgaggtc cccaatgcca cattcaaagc cctctcctac 600
aagaacggca ccatcctaaa ctgtgaatgc aagagaggtt tccgaagact aaaggaattg 660
gtctatatgc gttgcttagg aaactcctgg agcagcaact gccagtgcac cagcaactcc 720
catgacaaat cgagaaagca agttacagct caacttgaac accagaaaga gcaacaaacc 780
acaacagaca tgcagaagcc aacacagtct atgcaccaag agaaccttac aggtcactgc 840
agggagccac ctccttggaa acatgaagat tccaagagaa tctatcattt cgtggaagga 900
cagagtgttc actacgagtg tattccggga tacaaggctc tacagagagg tcctgctatt 960
agcatctgca agatgaagtg tgggaaaacg gggtggactc agccccagct cacatgtgta 1020
gatgaaagag aacaccaccg atttctggct agtgaggaat ctcaaggaag cagaaattct 1080
tctcccgaga gtgagacttc ctgccccata accaccacag acttcccaca acccacagaa 1140
acaactgcaa tgacggagac atttgtgctc acaatggagt ataagggtgg acatcaccat 1200
caccatcact aataa                                                  1215

<210> 43
<211> 360
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly3Ser)2-
      extracellular domain of IL-2 R

<400> 43
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys
    130                 135                 140                 
Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala
145                 150                 155                 160 
Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg
                165                 170                 175     
Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser
            180                 185                 190         
His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg
        195                 200                 205             
Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg
    210                 215                 220                 
Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser
225                 230                 235                 240 
Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr
                245                 250                 255     
Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys
            260                 265                 270         
Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys
        275                 280                 285             
Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys
    290                 295                 300                 
Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln
305                 310                 315                 320 
Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr
                325                 330                 335     
Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr
            340                 345                 350         
Ser Ile Phe Thr Thr Glu Tyr Gln
        355                 360 


<210> 44
<211> 380
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)2-
      extracellular domain of IL-2 R

<400> 44
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe
                165                 170                 175     
Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys
            180                 185                 190         
Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr
        195                 200                 205             
Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser
    210                 215                 220                 
Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu
225                 230                 235                 240 
Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val
                245                 250                 255     
Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu
            260                 265                 270         
Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val
        275                 280                 285             
Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala
    290                 295                 300                 
Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro
305                 310                 315                 320 
Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu
                325                 330                 335     
Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser
            340                 345                 350         
Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala
        355                 360                 365             
Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
    370                 375                 380 


<210> 45
<211> 355
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly3)- extracellular
      domain of IL-2 R

<400> 45
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Glu Leu Cys Asp Asp Asp Pro Pro
    130                 135                 140                 
Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr
145                 150                 155                 160 
Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly
                165                 170                 175     
Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp
            180                 185                 190         
Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln
        195                 200                 205             
Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met
    210                 215                 220                 
Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys
225                 230                 235                 240 
Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His
                245                 250                 255     
Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg
            260                 265                 270         
Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly
        275                 280                 285             
Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu
    290                 295                 300                 
Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly
305                 310                 315                 320 
Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln
                325                 330                 335     
Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr
            340                 345                 350         
Glu Tyr Gln
        355 


<210> 46
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3)-
      extracellular domain of IL-2 R

<400> 46
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Glu Leu Cys Asp
145                 150                 155                 160 
Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr
                165                 170                 175     
Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg
            180                 185                 190         
Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His
        195                 200                 205             
Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn
    210                 215                 220                 
Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys
225                 230                 235                 240 
Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu
                245                 250                 255     
Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu
            260                 265                 270         
Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val
        275                 280                 285             
Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys
    290                 295                 300                 
Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr
305                 310                 315                 320 
Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala
                325                 330                 335     
Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr
            340                 345                 350         
Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser
        355                 360                 365             
Ile Phe Thr Thr Glu Tyr Gln
    370                 375 


<210> 47
<211> 1170
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)2-
      extracellular domain of IL-2 R

<400> 47
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt 480
tcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc 540
tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc 600
gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt 660
caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa 720
cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc 780
cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat 840
catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac 900
agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc 960
cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag 1020
gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt 1080
caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag 1140
ggtggacatc accatcacca tcactaataa                                  1170

<210> 48
<211> 1155
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3)-
      extracellular domain of IL-2 R

<400> 48
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggtga gctctgtgac 480
gatgacccgc cagagatccc acacgccaca ttcaaagcca tggcctacaa ggaaggaacc 540
atgttgaact gtgaatgcaa gagaggtttc cgcagaataa aaagcgggtc actctatatg 600
ctctgtacag gaaactctag ccactcgtcc tgggacaacc aatgtcaatg cacaagctct 660
gccactcgga acacaacgaa acaagtgaca cctcaacctg aagaacagaa agaaaggaaa 720
accacagaaa tgcaaagtcc aatgcagcca gtggaccaag cgagccttcc aggtcactgc 780
agggaacctc caccatggga aaatgaagcc acagagagaa tttatcattt cgtggtgggg 840
cagatggttt attatcagtg cgtccaggga tacagggctc tacacagagg tcctgctgag 900
agcgtctgca aaatgaccca cgggaagaca aggtggaccc agccccagct catatgcaca 960
ggtgaaatgg agaccagtca gtttccaggt gaagagaagc ctcaggcaag ccccgaaggc 1020
cgtcctgaga gtgagacttc ctgcctcgtc acaacaacag attttcaaat acagacagaa 1080
atggctgcaa ccatggagac gtccatattt acaacagagt accagggtgg acatcaccat 1140
caccatcact aataa                                                  1155

<210> 49
<211> 1221
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R

<400> 49
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggtgg atcaggtgga 480
ggtggatctg gtggaggtgg atcaggtgga ggtggatccg gtggaggtgg atctgagctc 540
tgtgacgatg acccgccaga gatcccacac gccacattca aagccatggc ctacaaggaa 600
ggaaccatgt tgaactgtga atgcaagaga ggtttccgca gaataaaaag cgggtcactc 660
tatatgctct gtacaggaaa ctctagccac tcgtcctggg acaaccaatg tcaatgcaca 720
agctctgcca ctcggaacac aacgaaacaa gtgacacctc aacctgaaga acagaaagaa 780
aggaaaacca cagaaatgca aagtccaatg cagccagtgg accaagcgag ccttccaggt 840
cactgcaggg aacctccacc atgggaaaat gaagccacag agagaattta tcatttcgtg 900
gtggggcaga tggtttatta tcagtgcgtc cagggataca gggctctaca cagaggtcct 960
gctgagagcg tctgcaaaat gacccacggg aagacaaggt ggacccagcc ccagctcata 1020
tgcacaggtg aaatggagac cagtcagttt ccaggtgaag agaagcctca ggcaagcccc 1080
gaaggccgtc ctgagagtga gacttcctgc ctcgtcacaa caacagattt tcaaatacag 1140
acagaaatgg ctgcaaccat ggagacgtcc atatttacaa cagagtacca gggtggacat 1200
caccatcacc atcactaata a                                           1221

<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly4Ser)3 linker

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 51
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly4Ser)2 linker

<400> 51
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 52
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly4Ser)1 linker

<400> 52
Gly Gly Gly Gly Ser
 1               5  


<210> 53
<211> 10
<212> DNA
<213> Artificial Sequence

<220> 
<223> Kozak sequence

<400> 53
gccaccatgg                                                        10

<210> 54
<211> 412
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2
      (Gly4Ser)4-extracellular domain of IL-2 R + glycine
      spacer and poly-histidine region

<400> 54
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly
                165                 170                 175     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys
            180                 185                 190         
Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser
        195                 200                 205             
Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg
    210                 215                 220                 
Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser
225                 230                 235                 240 
Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln
                245                 250                 255     
Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp
            260                 265                 270         
Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His
        275                 280                 285             
Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr
    290                 295                 300                 
His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr
305                 310                 315                 320 
Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys
                325                 330                 335     
Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg
            340                 345                 350         
Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn
        355                 360                 365             
Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe
    370                 375                 380                 
Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr
385                 390                 395                 400 
Met Glu Tyr Lys Gly Gly His His His His His His
                405                 410         


<210> 55
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly4Ser)5-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 55
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly
                165                 170                 175     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            180                 185                 190         
Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr
        195                 200                 205             
Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys
    210                 215                 220                 
Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu
225                 230                 235                 240 
Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp
                245                 250                 255     
Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln
            260                 265                 270         
Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu
        275                 280                 285             
Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp
    290                 295                 300                 
Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu
305                 310                 315                 320 
Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile
                325                 330                 335     
Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr
            340                 345                 350         
Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser
        355                 360                 365             
Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile
    370                 375                 380                 
Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu
385                 390                 395                 400 
Thr Phe Val Leu Thr Met Glu Tyr Lys Gly Gly His His His His His
                405                 410                 415     
His
    


<210> 56
<211> 408
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 56
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly
                165                 170                 175     
Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro
            180                 185                 190         
Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly
        195                 200                 205             
Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu
    210                 215                 220                 
Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln
225                 230                 235                 240 
Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln
                245                 250                 255     
Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro
            260                 265                 270         
Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro
        275                 280                 285             
Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu
    290                 295                 300                 
Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln
305                 310                 315                 320 
Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly
                325                 330                 335     
Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg
            340                 345                 350         
Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu
        355                 360                 365             
Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr
    370                 375                 380                 
Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys
385                 390                 395                 400 
Gly Gly His His His His His His
                405             


<210> 57
<211> 404
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form of IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 57
Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu
 1               5                  10                  15      
Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala
            20                  25                  30          
Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu
        35                  40                  45              
Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn
    50                  55                  60                  
Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu
65                  70                  75                  80  
Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu
                85                  90                  95      
Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe
            100                 105                 110         
Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val
        115                 120                 125             
Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp
    130                 135                 140                 
Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys
145                 150                 155                 160 
Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly
                165                 170                 175     
Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro
            180                 185                 190         
Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn
        195                 200                 205             
Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met
    210                 215                 220                 
Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn
225                 230                 235                 240 
Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln
                245                 250                 255     
Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met
            260                 265                 270         
His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys
        275                 280                 285             
His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val
    290                 295                 300                 
His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala
305                 310                 315                 320 
Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro
                325                 330                 335     
Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser
            340                 345                 350         
Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser
        355                 360                 365             
Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala
    370                 375                 380                 
Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys Gly Gly His His
385                 390                 395                 400 
His His His His
                


<210> 58
<211> 388
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)2-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 58
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe
                165                 170                 175     
Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys
            180                 185                 190         
Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr
        195                 200                 205             
Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser
    210                 215                 220                 
Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu
225                 230                 235                 240 
Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val
                245                 250                 255     
Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu
            260                 265                 270         
Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val
        275                 280                 285             
Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala
    290                 295                 300                 
Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro
305                 310                 315                 320 
Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu
                325                 330                 335     
Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser
            340                 345                 350         
Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala
        355                 360                 365             
Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Gly Gly His His
    370                 375                 380                 
His His His His
385             


<210> 59
<211> 392
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form of IL-2 (Gly3Ser)3-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 59
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro
                165                 170                 175     
His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn
            180                 185                 190         
Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr
        195                 200                 205             
Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys
    210                 215                 220                 
Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro
225                 230                 235                 240 
Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro
                245                 250                 255     
Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro
            260                 265                 270         
Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val
        275                 280                 285             
Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His
    290                 295                 300                 
Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg
305                 310                 315                 320 
Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln
                325                 330                 335     
Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu
            340                 345                 350         
Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr
        355                 360                 365             
Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
    370                 375                 380                 
Gly Gly His His His His His His
385                 390         


<210> 60
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)4-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 60
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro
                165                 170                 175     
Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly
            180                 185                 190         
Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser
        195                 200                 205             
Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp
    210                 215                 220                 
Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys
225                 230                 235                 240 
Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu
                245                 250                 255     
Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His
            260                 265                 270         
Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr
        275                 280                 285             
His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr
    290                 295                 300                 
Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His
305                 310                 315                 320 
Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met
                325                 330                 335     
Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu
            340                 345                 350         
Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe
        355                 360                 365             
Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr
    370                 375                 380                 
Thr Glu Tyr Gln Gly Gly His His His His His His
385                 390                 395     


<210> 61
<211> 400
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly4Ser)4-
      extracellular domain of IL-2 R + glycine spacer
      and poly-histidine region

<400> 61
Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
 1               5                  10                  15      
Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu
            20                  25                  30          
Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile
        35                  40                  45              
Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe
    50                  55                  60                  
Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu
65                  70                  75                  80  
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys
                85                  90                  95      
Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile
            100                 105                 110         
Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala
        115                 120                 125             
Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe
    130                 135                 140                 
Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly
145                 150                 155                 160 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys
                165                 170                 175     
Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala
            180                 185                 190         
Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg
        195                 200                 205             
Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser
    210                 215                 220                 
His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg
225                 230                 235                 240 
Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg
                245                 250                 255     
Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser
            260                 265                 270         
Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr
        275                 280                 285             
Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys
    290                 295                 300                 
Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys
305                 310                 315                 320 
Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys
                325                 330                 335     
Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln
            340                 345                 350         
Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr
        355                 360                 365             
Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr
    370                 375                 380                 
Ser Ile Phe Thr Thr Glu Tyr Gln Gly Gly His His His His His His
385                 390                 395                 400 


<210> 62
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly3Ser)3-
      extracellular domain of mutIL-2 R

<400> 62
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly
    130                 135                 140                 
Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe
145                 150                 155                 160 
Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys
                165                 170                 175     
Arg Gly Phe Thr Ser Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr
            180                 185                 190         
Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser
        195                 200                 205             
Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu
    210                 215                 220                 
Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val
225                 230                 235                 240 
Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu
                245                 250                 255     
Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val
            260                 265                 270         
Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala
        275                 280                 285             
Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro
    290                 295                 300                 
Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu
305                 310                 315                 320 
Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser
                325                 330                 335     
Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala
            340                 345                 350         
Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln
        355                 360                 


<210> 63
<211> 1182
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly3Ser)3-
      extracellular domain of mutIL-2 R Mut

<400> 63
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt 480
tcaggtggag gttcggagct ctgtgacgat gacccgccag agatcccaca cgccacattc 540
aaagccatgg cctacaagga aggaaccatg ttgaactgtg aatgcaagag aggtttcacc 600
tcaataaaaa gcgggtcact ctatatgctc tgtacaggaa actctagcca ctcgtcctgg 660
gacaaccaat gtcaatgcac aagctctgcc actcggaaca caacgaaaca agtgacacct 720
caacctgaag aacagaaaga aaggaaaacc acagaaatgc aaagtccaat gcagccagtg 780
gaccaagcga gccttccagg tcactgcagg gaacctccac catgggaaaa tgaagccaca 840
gagagaattt atcatttcgt ggtggggcag atggtttatt atcagtgcgt ccagggatac 900
agggctctac acagaggtcc tgctgagagc gtctgcaaaa tgacccacgg gaagacaagg 960
tggacccagc cccagctcat atgcacaggt gaaatggaga ccagtcagtt tccaggtgaa 1020
gagaagcctc aggcaagccc cgaaggccgt cctgagagtg agacttcctg cctcgtcaca 1080
acaacagatt ttcaaataca gacagaaatg gctgcaacca tggagacgtc catatttaca 1140
acagagtacc agggtggaca tcaccatcac catcactaat aa                    1182

<210> 64
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized mature form IL-2 (Gly4Ser)4-
      extracellular domain of mutIL-2 R

<400> 64
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro
145                 150                 155                 160 
Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly
                165                 170                 175     
Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Thr Ser Ile Lys Ser
            180                 185                 190         
Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp
        195                 200                 205             
Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys
    210                 215                 220                 
Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu
225                 230                 235                 240 
Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His
                245                 250                 255     
Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr
            260                 265                 270         
His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr
        275                 280                 285             
Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His
    290                 295                 300                 
Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met
305                 310                 315                 320 
Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu
                325                 330                 335     
Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe
            340                 345                 350         
Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr
        355                 360                 365             
Thr Glu Tyr Gln
    370         


<210> 65
<211> 1206
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthesized unprocessed form IL-2 (Gly4Ser)4-
      extracellular domain of mutIL-2 R

<400> 65
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt 60
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 120
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 180
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 240
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 300
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 360
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 420
tggattacct tttgtcaaag catcatctca acactgactg gtggaggtgg atctggtgga 480
ggtggatcag gtggaggtgg atccggtgga ggtggatctg agctctgtga cgatgacccg 540
ccagagatcc cacacgccac attcaaagcc atggcctaca aggaaggaac catgttgaac 600
tgtgaatgca agagaggttt cacctcaata aaaagcgggt cactctatat gctctgtaca 660
ggaaactcta gccactcgtc ctgggacaac caatgtcaat gcacaagctc tgccactcgg 720
aacacaacga aacaagtgac acctcaacct gaagaacaga aagaaaggaa aaccacagaa 780
atgcaaagtc caatgcagcc agtggaccaa gcgagccttc caggtcactg cagggaacct 840
ccaccatggg aaaatgaagc cacagagaga atttatcatt tcgtggtggg gcagatggtt 900
tattatcagt gcgtccaggg atacagggct ctacacagag gtcctgctga gagcgtctgc 960
aaaatgaccc acgggaagac aaggtggacc cagccccagc tcatatgcac aggtgaaatg 1020
gagaccagtc agtttccagg tgaagagaag cctcaggcaa gccccgaagg ccgtcctgag 1080
agtgagactt cctgcctcgt cacaacaaca gattttcaaa tacagacaga aatggctgca 1140
accatggaga cgtccatatt tacaacagag taccagggtg gacatcacca tcaccatcac 1200
taataa                                                            1206
