                         SEQUENCE LISTING

<110>  Crown Bioscience, Inc.
       Zha, Jiping
       Sun, Ziyong
       Qiu, Junzhuan
 
<120>  ANTI PD-L1 ANTIBODIES

<130>  CRBI-007/01WO 

<150>  PCT/CN2014/083715
<151>  2014-08-05

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  1
gaggtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cattttcaga agctatggca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggtagcac ctactatcca      180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cttgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatg actgtgcaag aggctatgat      300

tcggggtttg cttattgggg ccaagggact ctggtcactg tctctgaa                   348


<210>  2
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  2

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Asp Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Glu 
        115     


<210>  3
<211>  336
<212>  DNA
<213>  Mus sp.

<400>  3
gacattgtgc tgacacagtc tcctgcttcc ttagctgttt ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acttctagct ctagttttat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaacgg                                336


<210>  4
<211>  112
<212>  PRT
<213>  Mus sp.

<400>  4

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  5
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  5
gaagtaaagt tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcaga agctatggca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggtaccac ctactatcca      180

gacagtgtga agggccgatt catcatctcc agagataatg ccaggaacat cctgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatt attgtgcaaa aggctatgat      300

tcggggtttg cttactgggg ccaagggact ctggtcattg tctctgca                   348


<210>  6
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  6

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Ile Val Ser Ala 
        115     


<210>  7
<211>  333
<212>  DNA
<213>  Mus sp.

<400>  7
gacattgtgc tgacacagtc tcctccttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagtt ctagttatat gcactggtac      120

caacagaaac caggacagcc tcccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  8
<211>  111
<212>  PRT
<213>  Mus sp.

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Ser Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  9
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact acctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggaatg gctgggagtg atatggcgtg gtgtaaccac agactataat      180

gcagctttca tgtccagact gaccatcacc aaggacaatt ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc taatgacaca gccatatatt actgtgccag actgggtttc      300

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  10
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  10

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  11
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca gcagaagcca      120

gggcagtctc ctaaactgct gatatattat gcagccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcat tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatacct ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  12
<211>  107
<212>  PRT
<213>  Mus sp.

<400>  12

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ala Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ile Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  13
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggagtcac agactataat      180

gcagctttca tatccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc taatgacaca gccatatatt actgtgccag actcggtttc      300

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  14
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  14

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Val Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  321
<212>  DNA
<213>  Mus sp.

<400>  15
agtattgtga tgacccagac tcccaaattc ctacttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag gttggtacca acagaagcca      120

gggcagtctc ctaaactact gatatactat gcatccaatc gctactctgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcaacaa gattatacct ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  16
<211>  107
<212>  PRT
<213>  Mus sp.

<400>  16

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  357
<212>  DNA
<213>  Mus sp.

<400>  17
gaggtgaagc tgttcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtgtag cctcaggatt cgattttagt acatactgga tgcattgggt ccggcaggct      120

ccagggcaag ggctagaatg gattggacaa attaatccag atagcactac gataaactat      180

gcgccatctc taaaggatag attcatcatc tccagagaca acgccaaaaa tacgctgttc      240

ctgcaaatga gcaaagtgag atctgaggac actgcccttt attactgtgc aaaacccggg      300

gactatggtt acgactttga ctgctggggc caaggcacca ctctcacagt ctcctca         357


<210>  18
<211>  119
<212>  PRT
<213>  Mus sp.

<400>  18

Glu Val Lys Leu Phe Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Asp Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asn Pro Asp Ser Thr Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Gly Asp Tyr Gly Tyr Asp Phe Asp Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  19
<211>  339
<212>  DNA
<213>  Mus sp.

<400>  19
gatgttttga tgacccaaac tccactctac ctgcctgtca gtcttggaga tcaggcctcc       60

atctcttgca gatctagtca gatcattgta catagtaatg caaacaccta tttagaatgg      120

ttcctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa ataaaacgg                             339


<210>  20
<211>  112
<212>  PRT
<213>  Mus sp.

<400>  20

Asp Val Leu Met Thr Gln Thr Pro Leu Tyr Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  357
<212>  DNA
<213>  Mus sp.

<400>  21
gaggtgcagc ttcaggagtc aggacctagc ctcgtgaaac cttctcagac tctgtccctc       60

acctgttctg tcactggcga ctccatcacc agtggttact ggaactggat ccggaaattc      120

ccagggaata aacttgagta catggggtac ataagctaca gtggtagcac ttactacaat      180

ccatctctca aaagtcgaat ctccatcact cgagacacat ccaagaacca gtactacctg      240

cagttgaatt ctgtgactac tgaggacaca gccacatatt actgtgcaag aagtctacta      300

tggttctcta cggggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  22
<211>  119
<212>  PRT
<213>  Mus sp.

<400>  22

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Leu Leu Trp Phe Ser Thr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  23
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  23
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctcctgggga gaaggtcacc       60

ttgacctgca gtgccagctc aagtgtaagt tccagctact tgtactggaa ccagcagaag      120

ccaggatcct cccccaaagt ctggatttat aacacatcca acctggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      240

gctgaagatg ctgcctctta tttctgccat cagtggagaa gttacccacc cacgctcggt      300

gctgggacca agctggagct gaaa                                             324


<210>  24
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  24

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Asn Gln Gln Lys Pro Gly Ser Ser Pro Lys Val Trp 
        35                  40                  45              


Ile Tyr Asn Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Arg Ser Tyr Pro 
                85                  90                  95      


Pro Thr Leu Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  25
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  25
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaatcac agactataat      180

gcagctttca aatccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

aagatgaaca gtctgcaagc taatgacaca gccatatatt tctgtgccag actgggtttt      300

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  26
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  26

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ile Thr Asp Tyr Asn Ala Ala Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  318
<212>  DNA
<213>  Mus sp.

<400>  27
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccaactc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acttccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat gggggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc catggacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  28
<211>  106
<212>  PRT
<213>  Mus sp.

<400>  28

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Gly Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  29
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  29
gaagtgaaac tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagg agctatggca tgtcttgggc tcgccagatt      120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggaaccac ctactatcta      180

gggagtgtgc agggccgatt cacaatctcc agagataatg ccaggaacat cctgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatt attgtgcaag aggctatgat      300

gcgggatttg cttactgggg ccaagggact ctggtcagtg tctctgaa                   348


<210>  30
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  30

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Ala Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Leu Gly Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ala Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Ser Val Ser Glu 
        115     


<210>  31
<211>  333
<212>  DNA
<213>  Mus sp.

<400>  31
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc tcccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcaga acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  32
<211>  111
<212>  PRT
<213>  Mus sp.

<400>  32

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Asn Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  33
<211>  351
<212>  DNA
<213>  Mus sp.

<400>  33
gaggtgcagc ttcaggagtc aggacctagc ctcgtcaaac cttctcagac tctgtccctc       60

acctgttctg tcactggcga ctccatcacc agtggttact ggacctggat ccggaaattc      120

ccagggaata aacttgaata catgggatac ataagctaca ctggtagcac ttactacaat      180

ccatctctca aaagtcgaat ctccatctct cgagacacat ccaagagcca gtactacctg      240

cagttgaatt ctgtgactac tgaggacaca gccacatatt actgtgcaag acagagggat      300

tggttagggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  34
<211>  117
<212>  PRT
<213>  Mus sp.

<400>  34

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Arg Asp Trp Leu Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  35
<211>  339
<212>  DNA
<213>  Mus sp.

<400>  35
gatattgtga tgacacagac tccatcctcc ctagctgtgt cacttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctccttggcc      120

tggtaccagc agaaaccagg acagtctcct aaactgctga tttactgggc atccaatagg      180

gaatctgggg tccctgatcg cttcacaggc agtagctctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  36
<211>  113
<212>  PRT
<213>  Mus sp.

<400>  36

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Asn Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Ser Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  37
<211>  348
<212>  DNA
<213>  Mus sp.

<400>  37
gaagagaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cagtttcagt agttatggca tgtcttgggt tcgtcagact      120

ccagagaaga ggctggagtg ggtcgcatcc atcagtagtg gtggtagtat ctactatcca      180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cctgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatt attgtgcaag aggctatgat      300

gcggggtttg ctttctgggg ccaagggaca ctggtcactg cctctgca                   348


<210>  38
<211>  116
<212>  PRT
<213>  Mus sp.

<400>  38

Glu Glu Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ala Gly Phe Ala Phe Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Ala Ser Ala 
        115     


<210>  39
<211>  333
<212>  DNA
<213>  Mus sp.

<400>  39
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagtt atagttatgt gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  40
<211>  111
<212>  PRT
<213>  Mus sp.

<400>  40

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  41
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11 antibody heavy chain variable region sequence

<400>  41
cagatcacac tgaaagaaag cggccctacc ctggtcaagc caactcagac cctgacactg       60

acttgcaccg tgtctgggtt ctctctgagt acatacggag tccactggat caggcagccc      120

cctggcaaag ctctggagtg gctgggagtg atttggcggg gcgtcaccac agactataac      180

gccgctttta tgtcaagact gacaatcact aaggataaca gcaaaaatca ggtggtcctg      240

accatgaaca atatggaccc cgtggatacc gcaacatact attgtgcccg gctggggttc      300

tacgccatgg actattgggg ccaggggact ctggtgaccg tctcgagc                   348


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11 antibody heavy chain variable region sequence

<400>  42

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Asn Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  43
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11 antibody light chain variable region sequence

<400>  43
gatatccaga tgactcagtc tccaagcagc ctgtctgcat ctgtggggga cagggtcacc       60

atcacatgca aagcatctca gagtgtgtca aacgatgtcg cctggtacca gcagaagccc      120

ggaaaagctc ctaagctgct gatttactat gccgctaatc ggtacactgg cgtgccagac      180

agattcagcg gatccggata tggaaccgat ttcactttta ccatcagctc cctgcagcca      240

gaggacattg ccacatattt ctgtcagcag gattacacaa gcccctatac ttttggccag      300

gggaccaaac tggaaatcaa g                                                321


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11 antibody light chain variable region sequence

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ala Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5 antibody heavy chain variable region sequence

<400>  45
gaggtgcagc tggtcgagtc aggagggggg ctggtcaagc caggagggtc actgcgactg       60

agctgcgcag cttccgggtt catctttagg tcttatggca tgagttgggt gcgccaggca      120

ccagggaaag gactggagtg ggtcgcttca atcagctccg gaggcagcac ttactatcct      180

gactccgtga agggccggtt caccatttct agagataacg ccaaaaatag tctgtacctg      240

cagatgaact ctctgcgagc agaagacaca gccgtctacg attgtgctag aggatatgac      300

agcggctttg catactgggg ccaggggacc ctggtgacag tctcgagc                   348


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5 antibody heavy chain variable region sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  47
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5 antibody light chain variable region sequence

<400>  47
gacattgtgc tgactcagag ccccgcttca ctggcagtgt ctccagggca gcgggcaacc       60

atcacatgca gagcctcaca gagcgtctcc accagctcct ctagtttcat gcactggtac      120

cagcagaagc ccggacagcc ccctaagctg ctgatcaaat atgctagcaa cctggagtcc      180

ggcgtgccag ccaggttctc tggcagtggg tcaggaaccg actttactct gaccattaat      240

cccgtcgaag ccaacgatac agctaattac tattgtcagc attcctggga gatcccttac      300

acatttggcc aggggactaa gctggagatc aag                                   333


<210>  48
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5 antibody light chain variable region sequence

<400>  48

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  49
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8C6-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  49
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggagtcac agactataat      180

gcagctttca tatccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc taatgacaca gccatatatt actgtgccag actcggtttc      300

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcgagcgc ctccaccaag      360

ggacccagcg tgtttcccct ggccccctgt tccagatcca cctccgaaag cacagccgct      420

ctcggctgcc tggtcaagga ttacttccct gagcccgtga cagtctcctg gaatagcggc      480

gctctgacct ccggcgtgca taccttccct gctgtgctgc aatcctccgg actgtacagc      540

ctgagcagcg tggtcaccgt gccttcctcc agcctgggaa ccaaaaccta cacatgcaac      600

gtggaccaca agcccagcaa caccaaagtg gacaagaggg tggagtccaa gtacggaccc      660

ccttgtcctc cctgccctgc tcctgaagcc gctggaggac ctagcgtgtt cctgtttccc      720

cccaagccca aggacaccct catgatctcc aggacccccg aggtgacctg tgtcgtggtg      780

gacgtgagcc aagaggaccc cgaggtgcag ttcaactggt acgtggatgg cgtcgaggtc      840

cataacgcca agaccaagcc tagggaggag cagttcaaca gcacctacag agtggtgagc      900

gtcctgaccg tgctccacca agactggctg aacggcaagg aatacaagtg caaggtctcc      960

aacaagggac tcccttcctc catcgagaag accatcagca aggccaaggg ccagcccaga     1020

gaaccccaag tctacacact gccccccagc caagaggaaa tgaccaagaa ccaggtgagc     1080

ctgacctgcc tggtgaaagg cttctacccc agcgacattg ctgtcgaatg ggagagcaac     1140

ggccaacccg agaacaacta caagaccacc ccccctgtgc tcgacagcga cggctccttc     1200

ttcctctaca gcaggctgac agtggacaag tccaggtggc aagagggcaa tgtcttcagc     1260

tgtagcgtca tgcacgaggc cctccacaac cactacaccc agaagagcct gtccctctcc     1320

ctgggctga                                                             1329


<210>  50
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C6-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  50

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Val Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  51
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8C6 chimeric antibody light chain full length sequence

<400>  51
agtattgtga tgacccagac tcccaaattc ctacttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag gttggtacca acagaagcca      120

gggcagtctc ctaaactact gatatactat gcatccaatc gctactctgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcaacaa gattatacct ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgtacggtg gccgcaccaa gcgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagctttaac agaggcgagt gctga                      645


<210>  52
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8C6 chimeric antibody light chain full length sequence

<400>  52

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  53
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8H4-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  53
gaagtgaaac tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagg agctatggca tgtcttgggc tcgccagatt      120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggaaccac ctactatcta      180

gggagtgtgc agggccgatt cacaatctcc agagataatg ccaggaacat cctgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatt attgtgcaag aggctatgat      300

gcgggatttg cttactgggg ccaagggact ctggtcagtg tctcgagcgc ctccaccaag      360

ggacccagcg tgtttcccct ggccccctgt tccagatcca cctccgaaag cacagccgct      420

ctcggctgcc tggtcaagga ttacttccct gagcccgtga cagtctcctg gaatagcggc      480

gctctgacct ccggcgtgca taccttccct gctgtgctgc aatcctccgg actgtacagc      540

ctgagcagcg tggtcaccgt gccttcctcc agcctgggaa ccaaaaccta cacatgcaac      600

gtggaccaca agcccagcaa caccaaagtg gacaagaggg tggagtccaa gtacggaccc      660

ccttgtcctc cctgccctgc tcctgaagcc gctggaggac ctagcgtgtt cctgtttccc      720

cccaagccca aggacaccct catgatctcc aggacccccg aggtgacctg tgtcgtggtg      780

gacgtgagcc aagaggaccc cgaggtgcag ttcaactggt acgtggatgg cgtcgaggtc      840

cataacgcca agaccaagcc tagggaggag cagttcaaca gcacctacag agtggtgagc      900

gtcctgaccg tgctccacca agactggctg aacggcaagg aatacaagtg caaggtctcc      960

aacaagggac tcccttcctc catcgagaag accatcagca aggccaaggg ccagcccaga     1020

gaaccccaag tctacacact gccccccagc caagaggaaa tgaccaagaa ccaggtgagc     1080

ctgacctgcc tggtgaaagg cttctacccc agcgacattg ctgtcgaatg ggagagcaac     1140

ggccaacccg agaacaacta caagaccacc ccccctgtgc tcgacagcga cggctccttc     1200

ttcctctaca gcaggctgac agtggacaag tccaggtggc aagagggcaa tgtcttcagc     1260

tgtagcgtca tgcacgaggc cctccacaac cactacaccc agaagagcct gtccctctcc     1320

ctgggctga                                                             1329


<210>  54
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  54

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Ala Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Leu Gly Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ala Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  55
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8H4 chimeric antibody light chain full length sequence

<400>  55
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc tcccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcaga acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaacgtacgg tggccgcacc aagcgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttta acagaggcga gtgctga         657


<210>  56
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H4 chimeric antibody light chain full length sequence

<400>  56

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Asn Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  57
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5G11-IgG1 (D265A) chimeric antibody heavy chain full length sequence

<400>  57
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact acctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggaatg gctgggagtg atatggcgtg gtgtaaccac agactataat      180

gcagctttca tgtccagact gaccatcacc aaggacaatt ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc taatgacaca gccatatatt actgtgccag actgggtttc      300

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcgagcgc ctccactaag      360

ggcccatccg tgttccctct ggcaccctcc agcaagagca caagcggagg caccgccgca      420

ctgggctgcc tcgtgaagga ctacttccca gaacccgtga ccgtcagctg gaatagcggc      480

gctctgacca gcggagtcca cactttcccc gcagtgctgc agtccagcgg cctgtacagc      540

ctgagcagcg tggtcactgt gccaagcagc agcctgggca ctcagaccta catctgcaac      600

gtcaaccaca agcccagcaa cacaaaggtg gacaagaagg tcgagcccaa gtcctgcgat      660

aagacccaca cctgccctcc atgtcccgcc cccgagctgc tgggaggacc cagcgtcttc      720

ctgtttcccc ccaagccaaa ggacaccctg atgatcagca ggacccccga agtgacctgc      780

gtcgtggtgg ccgtgagcca cgaagatccc gaggtgaagt tcaactggta cgtggacggc      840

gtggaagtgc acaacgccaa gacaaaaccc agggaggagc agtatgccag cacctacagg      900

gtcgtgagcg tcctgaccgt gctgcaccaa gactggctga acggcaagga gtataagtgc      960

aaggtgagca acaaggcact gcccgccccc atcgagaaga ccatttccaa ggccaagggg     1020

caacctaggg agccacaggt ctacactctg ccccctagca gggacgagct gaccaagaac     1080

caggtctccc tgacttgcct ggtgaagggg ttttatccca gcgacatcgc cgtcgagtgg     1140

gagagcaatg gccagcccga aaacaactac aagaccacac cccctgtgct ggacagcgac     1200

ggcagcttct ttctgtatag caaactgaca gtggataaga gcagatggca gcagggcaac     1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc ccggaaaatg a                                               1341


<210>  58
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G11-IgG1 (D265A) chimeric antibody heavy chain full length sequence

<400>  58

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  59
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5G11-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  59
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact acctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggaatg gctgggagtg atatggcgtg gtgtaaccac agactataat      180

gcagctttca tgtccagact gaccatcacc aaggacaatt ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc taatgacaca gccatatatt actgtgccag actgggtttc      300

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcgagcgc ctccaccaag      360

ggacccagcg tgtttcccct ggccccctgt tccagatcca cctccgaaag cacagccgct      420

ctcggctgcc tggtcaagga ttacttccct gagcccgtga cagtctcctg gaatagcggc      480

gctctgacct ccggcgtgca taccttccct gctgtgctgc aatcctccgg actgtacagc      540

ctgagcagcg tggtcaccgt gccttcctcc agcctgggaa ccaaaaccta cacatgcaac      600

gtggaccaca agcccagcaa caccaaagtg gacaagaggg tggagtccaa gtacggaccc      660

ccttgtcctc cctgccctgc tcctgaagcc gctggaggac ctagcgtgtt cctgtttccc      720

cccaagccca aggacaccct catgatctcc aggacccccg aggtgacctg tgtcgtggtg      780

gacgtgagcc aagaggaccc cgaggtgcag ttcaactggt acgtggatgg cgtcgaggtc      840

cataacgcca agaccaagcc tagggaggag cagttcaaca gcacctacag agtggtgagc      900

gtcctgaccg tgctccacca agactggctg aacggcaagg aatacaagtg caaggtctcc      960

aacaagggac tcccttcctc catcgagaag accatcagca aggccaaggg ccagcccaga     1020

gaaccccaag tctacacact gccccccagc caagaggaaa tgaccaagaa ccaggtgagc     1080

ctgacctgcc tggtgaaagg cttctacccc agcgacattg ctgtcgaatg ggagagcaac     1140

ggccaacccg agaacaacta caagaccacc ccccctgtgc tcgacagcga cggctccttc     1200

ttcctctaca gcaggctgac agtggacaag tccaggtggc aagagggcaa tgtcttcagc     1260

tgtagcgtca tgcacgaggc cctccacaac cactacaccc agaagagcct gtccctctcc     1320

ctgggctga                                                             1329


<210>  60
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G11-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  60

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  61
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5G11 chimeric antibody light chain full length sequence

<400>  61
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca gcagaagcca      120

gggcagtctc ctaaactgct gatatattat gcagccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcat tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatacct ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgtacggtg gccgcaccaa gcgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagctttaac agaggcgagt gctga                      645


<210>  62
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G11 chimeric antibody light chain full length sequence

<400>  62

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ala Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ile Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  63
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C5-IgG1 (D265A) chimeric antibody heavy chain full length sequence

<400>  63
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cattttcaga agctatggca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggtagcac ctactatcca      180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cttgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatg actgtgcaag aggctatgat      300

tcggggtttg cttattgggg ccaagggact ctggtcactg tctcgagcgc ctccactaag      360

ggcccatccg tgttccctct ggcaccctcc agcaagagca caagcggagg caccgccgca      420

ctgggctgcc tcgtgaagga ctacttccca gaacccgtga ccgtcagctg gaatagcggc      480

gctctgacca gcggagtcca cactttcccc gcagtgctgc agtccagcgg cctgtacagc      540

ctgagcagcg tggtcactgt gccaagcagc agcctgggca ctcagaccta catctgcaac      600

gtcaaccaca agcccagcaa cacaaaggtg gacaagaagg tcgagcccaa gtcctgcgat      660

aagacccaca cctgccctcc atgtcccgcc cccgagctgc tgggaggacc cagcgtcttc      720

ctgtttcccc ccaagccaaa ggacaccctg atgatcagca ggacccccga agtgacctgc      780

gtcgtggtgg ccgtgagcca cgaagatccc gaggtgaagt tcaactggta cgtggacggc      840

gtggaagtgc acaacgccaa gacaaaaccc agggaggagc agtatgccag cacctacagg      900

gtcgtgagcg tcctgaccgt gctgcaccaa gactggctga acggcaagga gtataagtgc      960

aaggtgagca acaaggcact gcccgccccc atcgagaaga ccatttccaa ggccaagggg     1020

caacctaggg agccacaggt ctacactctg ccccctagca gggacgagct gaccaagaac     1080

caggtctccc tgacttgcct ggtgaagggg ttttatccca gcgacatcgc cgtcgagtgg     1140

gagagcaatg gccagcccga aaacaactac aagaccacac cccctgtgct ggacagcgac     1200

ggcagcttct ttctgtatag caaactgaca gtggataaga gcagatggca gcagggcaac     1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc ccggaaaatg a                                               1341


<210>  64
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C5-IgG1 (D265A) chimeric antibody heavy chain full length sequence

<400>  64

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Asp Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  65
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C5-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  65
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cattttcaga agctatggca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatcc attagtagtg gtggtagcac ctactatcca      180

gacagtgtga agggccgatt caccatctcc agagataatg ccaggaacat cttgtacctg      240

caaatgagca gtctgaggtc tgaggacacg gccatgtatg actgtgcaag aggctatgat      300

tcggggtttg cttattgggg ccaagggact ctggtcactg tctcgagcgc ctccaccaag      360

ggacccagcg tgtttcccct ggccccctgt tccagatcca cctccgaaag cacagccgct      420

ctcggctgcc tggtcaagga ttacttccct gagcccgtga cagtctcctg gaatagcggc      480

gctctgacct ccggcgtgca taccttccct gctgtgctgc aatcctccgg actgtacagc      540

ctgagcagcg tggtcaccgt gccttcctcc agcctgggaa ccaaaaccta cacatgcaac      600

gtggaccaca agcccagcaa caccaaagtg gacaagaggg tggagtccaa gtacggaccc      660

ccttgtcctc cctgccctgc tcctgaagcc gctggaggac ctagcgtgtt cctgtttccc      720

cccaagccca aggacaccct catgatctcc aggacccccg aggtgacctg tgtcgtggtg      780

gacgtgagcc aagaggaccc cgaggtgcag ttcaactggt acgtggatgg cgtcgaggtc      840

cataacgcca agaccaagcc tagggaggag cagttcaaca gcacctacag agtggtgagc      900

gtcctgaccg tgctccacca agactggctg aacggcaagg aatacaagtg caaggtctcc      960

aacaagggac tcccttcctc catcgagaag accatcagca aggccaaggg ccagcccaga     1020

gaaccccaag tctacacact gccccccagc caagaggaaa tgaccaagaa ccaggtgagc     1080

ctgacctgcc tggtgaaagg cttctacccc agcgacattg ctgtcgaatg ggagagcaac     1140

ggccaacccg agaacaacta caagaccacc ccccctgtgc tcgacagcga cggctccttc     1200

ttcctctaca gcaggctgac agtggacaag tccaggtggc aagagggcaa tgtcttcagc     1260

tgtagcgtca tgcacgaggc cctccacaac cactacaccc agaagagcct gtccctctcc     1320

ctgggctga                                                             1329


<210>  66
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C5-IgG4 (F234A/L235A) chimeric antibody heavy chain full length sequence

<400>  66

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Asp Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  67
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C5 chimeric antibody light chain full length sequence

<400>  67
gacattgtgc tgacacagtc tcctgcttcc ttagctgttt ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acttctagct ctagttttat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaacgtacgc gtacggtggc cgcaccaagc      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gctttaacag aggcgagtgc      660

tga                                                                    663


<210>  68
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C5 chimeric antibody light chain full length sequence

<400>  68

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  69
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11-IgG1 (D265A) antibody heavy chain full length sequence

<400>  69
cagatcacac tgaaagaaag cggccctacc ctggtcaagc caactcagac cctgacactg       60

acttgcaccg tgtctgggtt ctctctgagt acatacggag tccactggat caggcagccc      120

cctggcaaag ctctggagtg gctgggagtg atttggcggg gcgtcaccac agactataac      180

gccgctttta tgtcaagact gacaatcact aaggataaca gcaaaaatca ggtggtcctg      240

accatgaaca atatggaccc cgtggatacc gcaacatact attgtgcccg gctggggttc      300

tacgccatgg actattgggg ccaggggact ctggtgaccg tctcgagcgc ctccactaag      360

ggcccatccg tgttccctct ggcaccctcc agcaagagca caagcggagg caccgccgca      420

ctgggctgcc tcgtgaagga ctacttccca gaacccgtga ccgtcagctg gaatagcggc      480

gctctgacca gcggagtcca cactttcccc gcagtgctgc agtccagcgg cctgtacagc      540

ctgagcagcg tggtcactgt gccaagcagc agcctgggca ctcagaccta catctgcaac      600

gtcaaccaca agcccagcaa cacaaaggtg gacaagaagg tcgagcccaa gtcctgcgat      660

aagacccaca cctgccctcc atgtcccgcc cccgagctgc tgggaggacc cagcgtcttc      720

ctgtttcccc ccaagccaaa ggacaccctg atgatcagca ggacccccga agtgacctgc      780

gtcgtggtgg ccgtgagcca cgaagatccc gaggtgaagt tcaactggta cgtggacggc      840

gtggaagtgc acaacgccaa gacaaaaccc agggaggagc agtataacag cacctacagg      900

gtcgtgagcg tcctgaccgt gctgcaccaa gactggctga acggcaagga gtataagtgc      960

aaggtgagca acaaggcact gcccgccccc atcgagaaga ccatttccaa ggccaagggg     1020

caacctaggg agccacaggt ctacactctg ccccctagca gggacgagct gaccaagaac     1080

caggtctccc tgacttgcct ggtgaagggg ttttatccca gcgacatcgc cgtcgagtgg     1140

gagagcaatg gccagcccga aaacaactac aagaccacac cccctgtgct ggacagcgac     1200

ggcagcttct ttctgtatag caaactgaca gtggataaga gcagatggca gcagggcaac     1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc ccggaaaatg a                                               1341


<210>  70
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11-IgG1 (D265A) antibody heavy chain full length sequence

<400>  70

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Asn Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  71
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11-IgG4 (F234A/L235A) antibody heavy chain full length sequence

<400>  71
cagatcacac tgaaagaaag cggccctacc ctggtcaagc caactcagac cctgacactg       60

acttgcaccg tgtctgggtt ctctctgagt acatacggag tccactggat caggcagccc      120

cctggcaaag ctctggagtg gctgggagtg atttggcggg gcgtcaccac agactataac      180

gccgctttta tgtcaagact gacaatcact aaggataaca gcaaaaatca ggtggtcctg      240

accatgaaca atatggaccc cgtggatacc gcaacatact attgtgcccg gctggggttc      300

tacgccatgg actattgggg ccaggggact ctggtgaccg tctcgagcgc ctccaccaag      360

ggacccagcg tgtttcccct ggccccctgt tccagatcca cctccgaaag cacagccgct      420

ctcggctgcc tggtcaagga ttacttccct gagcccgtga cagtctcctg gaatagcggc      480

gctctgacct ccggcgtgca taccttccct gctgtgctgc aatcctccgg actgtacagc      540

ctgagcagcg tggtcaccgt gccttcctcc agcctgggaa ccaaaaccta cacatgcaac      600

gtggaccaca agcccagcaa caccaaagtg gacaagaggg tggagtccaa gtacggaccc      660

ccttgtcctc cctgccctgc tcctgaagcc gctggaggac ctagcgtgtt cctgtttccc      720

cccaagccca aggacaccct catgatctcc aggacccccg aggtgacctg tgtcgtggtg      780

gacgtgagcc aagaggaccc cgaggtgcag ttcaactggt acgtggatgg cgtcgaggtc      840

cataacgcca agaccaagcc tagggaggag cagttcaaca gcacctacag agtggtgagc      900

gtcctgaccg tgctccacca agactggctg aacggcaagg aatacaagtg caaggtctcc      960

aacaagggac tcccttcctc catcgagaag accatcagca aggccaaggg ccagcccaga     1020

gaaccccaag tctacacact gccccccagc caagaggaaa tgaccaagaa ccaggtgagc     1080

ctgacctgcc tggtgaaagg cttctacccc agcgacattg ctgtcgaatg ggagagcaac     1140

ggccaacccg agaacaacta caagaccacc ccccctgtgc tcgacagcga cggctccttc     1200

ttcctctaca gcaggctgac agtggacaag tccaggtggc aagagggcaa tgtcttcagc     1260

tgtagcgtca tgcacgaggc cctccacaac cactacaccc agaagagcct gtccctctcc     1320

ctgggctga                                                             1329


<210>  72
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11-IgG4 (F234A/L235A) antibody heavy chain full length sequence

<400>  72

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Asn Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  73
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11 antibody light chain full length sequence

<400>  73
gatatccaga tgactcagtc tccaagcagc ctgtctgcat ctgtggggga cagggtcacc       60

atcacatgca aagcatctca gagtgtgtca aacgatgtcg cctggtacca gcagaagccc      120

ggaaaagctc ctaagctgct gatttactat gccgctaatc ggtacactgg cgtgccagac      180

agattcagcg gatccggata tggaaccgat ttcactttta ccatcagctc cctgcagcca      240

gaggacattg ccacatattt ctgtcagcag gattacacaa gcccctatac ttttggccag      300

gggaccaaac tggaaatcaa gcgtacggtg gccgcaccaa gcgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagctttaac agaggcgagt gctga                      645


<210>  74
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 5G11 antibody light chain full length sequence

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ala Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  75
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5-IgG1 (D265A) antibody heavy chain full length sequence

<400>  75
gaggtgcagc tggtcgagtc aggagggggg ctggtcaagc caggagggtc actgcgactg       60

agctgcgcag cttccgggtt catctttagg tcttatggca tgagttgggt gcgccaggca      120

ccagggaaag gactggagtg ggtcgcttca atcagctccg gaggcagcac ttactatcct      180

gactccgtga agggccggtt caccatttct agagataacg ccaaaaatag tctgtacctg      240

cagatgaact ctctgcgagc agaagacaca gccgtctacg attgtgctag aggatatgac      300

agcggctttg catactgggg ccaggggacc ctggtgacag tctcgagcgc ctccactaag      360

ggcccatccg tgttccctct ggcaccctcc agcaagagca caagcggagg caccgccgca      420

ctgggctgcc tcgtgaagga ctacttccca gaacccgtga ccgtcagctg gaatagcggc      480

gctctgacca gcggagtcca cactttcccc gcagtgctgc agtccagcgg cctgtacagc      540

ctgagcagcg tggtcactgt gccaagcagc agcctgggca ctcagaccta catctgcaac      600

gtcaaccaca agcccagcaa cacaaaggtg gacaagaagg tcgagcccaa gtcctgcgat      660

aagacccaca cctgccctcc atgtcccgcc cccgagctgc tgggaggacc cagcgtcttc      720

ctgtttcccc ccaagccaaa ggacaccctg atgatcagca ggacccccga agtgacctgc      780

gtcgtggtgg ccgtgagcca cgaagatccc gaggtgaagt tcaactggta cgtggacggc      840

gtggaagtgc acaacgccaa gacaaaaccc agggaggagc agtataacag cacctacagg      900

gtcgtgagcg tcctgaccgt gctgcaccaa gactggctga acggcaagga gtataagtgc      960

aaggtgagca acaaggcact gcccgccccc atcgagaaga ccatttccaa ggccaagggg     1020

caacctaggg agccacaggt ctacactctg ccccctagca gggacgagct gaccaagaac     1080

caggtctccc tgacttgcct ggtgaagggg ttttatccca gcgacatcgc cgtcgagtgg     1140

gagagcaatg gccagcccga aaacaactac aagaccacac cccctgtgct ggacagcgac     1200

ggcagcttct ttctgtatag caaactgaca gtggataaga gcagatggca gcagggcaac     1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagtccctg     1320

agcctgtccc ccggaaaatg a                                               1341


<210>  76
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5-IgG1 (D265A) antibody heavy chain full length sequence

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  77
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5-IgG4 (F234A/L235A) antibody heavy chain full length sequence

<400>  77
gaggtgcagc tggtcgagtc aggagggggg ctggtcaagc caggagggtc actgcgactg       60

agctgcgcag cttccgggtt catctttagg tcttatggca tgagttgggt gcgccaggca      120

ccagggaaag gactggagtg ggtcgcttca atcagctccg gaggcagcac ttactatcct      180

gactccgtga agggccggtt caccatttct agagataacg ccaaaaatag tctgtacctg      240

cagatgaact ctctgcgagc agaagacaca gccgtctacg attgtgctag aggatatgac      300

agcggctttg catactgggg ccaggggacc ctggtgacag tctcgagcgc ctccaccaag      360

ggacccagcg tgtttcccct ggccccctgt tccagatcca cctccgaaag cacagccgct      420

ctcggctgcc tggtcaagga ttacttccct gagcccgtga cagtctcctg gaatagcggc      480

gctctgacct ccggcgtgca taccttccct gctgtgctgc aatcctccgg actgtacagc      540

ctgagcagcg tggtcaccgt gccttcctcc agcctgggaa ccaaaaccta cacatgcaac      600

gtggaccaca agcccagcaa caccaaagtg gacaagaggg tggagtccaa gtacggaccc      660

ccttgtcctc cctgccctgc tcctgaagcc gctggaggac ctagcgtgtt cctgtttccc      720

cccaagccca aggacaccct catgatctcc aggacccccg aggtgacctg tgtcgtggtg      780

gacgtgagcc aagaggaccc cgaggtgcag ttcaactggt acgtggatgg cgtcgaggtc      840

cataacgcca agaccaagcc tagggaggag cagttcaaca gcacctacag agtggtgagc      900

gtcctgaccg tgctccacca agactggctg aacggcaagg aatacaagtg caaggtctcc      960

aacaagggac tcccttcctc catcgagaag accatcagca aggccaaggg ccagcccaga     1020

gaaccccaag tctacacact gccccccagc caagaggaaa tgaccaagaa ccaggtgagc     1080

ctgacctgcc tggtgaaagg cttctacccc agcgacattg ctgtcgaatg ggagagcaac     1140

ggccaacccg agaacaacta caagaccacc ccccctgtgc tcgacagcga cggctccttc     1200

ttcctctaca gcaggctgac agtggacaag tccaggtggc aagagggcaa tgtcttcagc     1260

tgtagcgtca tgcacgaggc cctccacaac cactacaccc agaagagcct gtccctctcc     1320

ctgggctga                                                             1329


<210>  78
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5-IgG4 (F234A/L235A) antibody heavy chain full length sequence

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys Ala 
                85                  90                  95      


Arg Gly Tyr Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  79
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5 antibody light chain full length sequence

<400>  79
gacattgtgc tgactcagag ccccgcttca ctggcagtgt ctccagggca gcgggcaacc       60

atcacatgca gagcctcaca gagcgtctcc accagctcct ctagtttcat gcactggtac      120

cagcagaagc ccggacagcc ccctaagctg ctgatcaaat atgctagcaa cctggagtcc      180

ggcgtgccag ccaggttctc tggcagtggg tcaggaaccg actttactct gaccattaat      240

cccgtcgaag ccaacgatac agctaattac tattgtcagc attcctggga gatcccttac      300

acatttggcc aggggactaa gctggagatc aagcgtacgg tggccgcacc aagcgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttta acagaggcga gtgctga         657


<210>  80
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13C5 antibody light chain full length sequence

<400>  80

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  81
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  81

Ser Tyr Gly Met Ser 
1               5   


<210>  82
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  82

Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  83
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  83

Gly Tyr Asp Ser Gly Phe Ala Tyr 
1               5               


<210>  84
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  84

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Ser Ser Phe Met His 
1               5                   10                  15  


<210>  85
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  85

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  86

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  87
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  87

Ser Tyr Gly Met Ser 
1               5   


<210>  88
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  88

Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  89
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  89

Gly Tyr Asp Ser Gly Phe Ala Tyr 
1               5               


<210>  90
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  90

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Ser Ser Tyr Met His 
1               5                   10                  15  


<210>  91
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  91

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  92
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  92

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  93
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  93

Thr Tyr Gly Val His 
1               5   


<210>  94
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  94

Val Ile Trp Arg Gly Val Thr Thr Asp Tyr Asn Ala Ala Phe Met Ser 
1               5                   10                  15      


<210>  95
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  95

Leu Gly Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  96
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  96

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  97
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  97

Tyr Ala Ala Asn Arg Tyr Thr 
1               5           


<210>  98
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  98

Gln Gln Asp Tyr Thr Ser Pro Tyr Thr 
1               5                   


<210>  99
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  99

Ser Tyr Gly Val His 
1               5   


<210>  100
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  100

Val Ile Trp Ser Gly Gly Val Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  101
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  101

Leu Gly Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  102
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  102

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Gly 
1               5                   10      


<210>  103
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  103

Tyr Ala Ser Asn Arg Tyr Ser 
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  104

Gln Gln Asp Tyr Thr Ser Pro Tyr Thr 
1               5                   


<210>  105
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  105

Thr Tyr Trp Met His 
1               5   


<210>  106
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  106

Gln Ile Asn Pro Asp Ser Thr Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  107
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  107

Pro Gly Asp Tyr Gly Tyr Asp Phe Asp Cys 
1               5                   10  


<210>  108
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  108

Arg Ser Ser Gln Ile Ile Val His Ser Asn Ala Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  109
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  109

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  110
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  110

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  111
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  111

Ser Gly Tyr Trp Asn 
1               5   


<210>  112
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  112

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  113
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  113

Ser Leu Leu Trp Phe Ser Thr Gly Phe Ala Tyr 
1               5                   10      


<210>  114
<211>  12
<212>  PRT
<213>  Mus sp.

<400>  114

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210>  115
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  115

Asn Thr Ser Asn Leu Ala Ser 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  116

His Gln Trp Arg Ser Tyr Pro Pro Thr 
1               5                   


<210>  117
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  117

Ser Tyr Gly Val His 
1               5   


<210>  118
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  118

Val Ile Trp Ser Gly Gly Ile Thr Asp Tyr Asn Ala Ala Phe Lys Ser 
1               5                   10                  15      


<210>  119
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  119

Leu Gly Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  120
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  120

Ser Ala Asn Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  121
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  121

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  122
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  122

Gln Gln Trp Ser Ser Asn Pro Trp Thr 
1               5                   


<210>  123
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  123

Ser Tyr Gly Met Ser 
1               5   


<210>  124
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  124

Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Leu Gly Ser Val Gln Gly 
1               5                   10                  15      


<210>  125
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  125

Gly Tyr Asp Ala Gly Phe Ala Tyr 
1               5               


<210>  126
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  126

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  127
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  127

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  128

Gln Asn Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  129
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  129

Ser Gly Tyr Trp Thr 
1               5   


<210>  130
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  130

Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  131
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  131

Gln Arg Asp Trp Leu Gly Phe Ala Tyr 
1               5                   


<210>  132
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  132

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  133
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  133

Trp Ala Ser Asn Arg Glu Ser 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  134

Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  135
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  135

Ser Tyr Gly Met Ser 
1               5   


<210>  136
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  136

Ser Ile Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  137
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  137

Gly Tyr Asp Ala Gly Phe Ala Phe 
1               5               


<210>  138
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  138

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Val His 
1               5                   10                  15  


<210>  139
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  139

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  140

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  141
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  141
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660


<210>  142
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  142

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  143
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  143
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

catcatcacc accatcacta a                                                681


<210>  144
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  144

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg His His His His 
    210                 215                 220                 


His His 
225     


<210>  145
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PD-L1-mFc sequence

<400>  145
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

ggtaccagat ctagaggctg caaaccctgt atctgcacag tgcccgaggt gagctccgtg      720

ttcatctttc cccccaagcc caaggacgtg ctgaccatca cactcacacc caaggtcacc      780

tgcgtggtcg tggacatctc caaggacgac cccgaagtcc agttcagctg gttcgtggac      840

gacgtggagg tgcacaccgc tcagacccaa cccagagagg agcagtttaa ctccaccttc      900

aggtccgtgt ccgagctccc catcatgcac caggactggc tgaatggcaa ggagttcaag      960

tgcagggtga actccgctgc tttccccgcc cccattgaga agaccatctc caagaccaag     1020

ggaaggccca aggcccccca ggtgtacacc attccccctc ccaaggagca gatggccaag     1080

gacaaggtgt ccctgacctg tatgatcacc gacttctttc ccgaggacat caccgtcgaa     1140

tggcagtgga acggccagcc cgccgagaac tataagaaca cccaacccat catggacacc     1200

gacggcagct acttcgtgta tagcaagctc aacgtgcaga agagcaactg ggaagccgga     1260

aataccttca cctgctccgt cctgcacgag ggcctgcaca accaccatac cgaaaagagc     1320

ctgagccaca gccccggaaa gtaa                                            1344


<210>  146
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PD-L1-mFc sequence

<400>  146

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Gly Thr Arg Ser 
    210                 215                 220                 


Arg Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  147
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PD-L1-hFc sequence

<400>  147
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

ggtaccagat ctagagagcc caaatcttct gacaaaactc acacatgccc accgtgccca      720

gcacctgaat tcgagggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggactcc tgaggtcaca tgcgtggtgg tggacgtaag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaacc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1374


<210>  148
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PD-L1-hFc sequence

<400>  148

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Gly Thr Arg Ser 
    210                 215                 220                 


Arg Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Phe Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Thr Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  149
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cyno-PD-L1-HisTag

<400>  149
tttactgtca cggttcccaa ggacctatat gtggtagagt atggcagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctgactt cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtaactaca gacagagggc ccagctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcggatca cagatgtgaa attgcaggat gcaggggttt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg gattaccgtg aaagtcaatg ctccatacaa caaaatcaac      360

caaagaattt tggttgtcga tccagtcacc tctgaacatg aactaacatg tcaggctgag      420

ggctacccca aggccgaagt catttggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttaa atgtgaccag cacactgaga      540

atcaacacaa cagctaatga gattttctac tgcattttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cgcttcctcc aaatgaaagg      660

catcatcacc accatcacta a                                                681


<210>  150
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno-PD-L1-HisTag

<400>  150

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Thr Ser Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Asn Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Arg Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Ile 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala Leu Pro Pro Asn Glu Arg His His His His 
    210                 215                 220                 


His His 
225     


<210>  151
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  151
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg                                       450


<210>  152
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  152

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  153
<211>  1134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PD-1-mFc sequence

<400>  153
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg ggtaccagat ctagaggctg caaaccctgt      480

atctgcacag tgcccgaggt gagctccgtg ttcatctttc cccccaagcc caaggacgtg      540

ctgaccatca cactcacacc caaggtcacc tgcgtggtcg tggacatctc caaggacgac      600

cccgaagtcc agttcagctg gttcgtggac gacgtggagg tgcacaccgc tcagacccaa      660

cccagagagg agcagtttaa ctccaccttc aggtccgtgt ccgagctccc catcatgcac      720

caggactggc tgaatggcaa ggagttcaag tgcagggtga actccgctgc tttccccgcc      780

cccattgaga agaccatctc caagaccaag ggaaggccca aggcccccca ggtgtacacc      840

attccccctc ccaaggagca gatggccaag gacaaggtgt ccctgacctg tatgatcacc      900

gacttctttc ccgaggacat caccgtcgaa tggcagtgga acggccagcc cgccgagaac      960

tataagaaca cccaacccat catggacacc gacggcagct acttcgtgta tagcaagctc     1020

aacgtgcaga agagcaactg ggaagccgga aataccttca cctgctccgt cctgcacgag     1080

ggcctgcaca accaccatac cgaaaagagc ctgagccaca gccccggaaa gtaa           1134


<210>  154
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PD-1-mFc sequence

<400>  154

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Thr Arg Ser Arg Gly Cys Lys Pro Cys 
145                 150                 155                 160 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
        195                 200                 205             


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
                245                 250                 255     


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
            260                 265                 270         


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
        275                 280                 285             


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
    290                 295                 300                 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
305                 310                 315                 320 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
                325                 330                 335     


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
            340                 345                 350         


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
        355                 360                 365             


Lys Ser Leu Ser His Ser Pro Gly Lys 
    370                 375         


<210>  155
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human PD-1-hFc sequence

<400>  155
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg ggtaccagat ctagagagcc caaatcttct      480

gacaaaactc acacatgccc accgtgccca gcacctgaat tcgagggtgc accgtcagtc      540

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggactcc tgaggtcaca      600

tgcgtggtgg tggacgtaag ccacgaagac cctgaggtca agttcaactg gtacgtggac      660

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      720

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      780

tgcaaggtct ccaacaaagc cctcccaacc cccatcgaga aaaccatctc caaagccaaa      840

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      900

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc caagcgacat cgccgtggag      960

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1020

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1080

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1140

ctctccctgt ctccgggtaa atga                                            1164


<210>  156
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PD-1-hFc sequence

<400>  156

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Thr Arg Ser Arg Glu Pro Lys Ser Ser 
145                 150                 155                 160 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
                165                 170                 175     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            180                 185                 190         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        195                 200                 205             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    210                 215                 220         


