                         SEQUENCE LISTING

<110>  Duke University
 
<120>  COMPOSITIONS AND METHODS FOR IDENTIFYING AND TREATING CONDITIONS 
       INVOLVING HSF1 ACTIVITY

<130>  DUKE-34023/WO-1/PCT

<150>  US62/033,002
<151>  2014-08-04

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N = A, C, T, or G

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  N = A, C, T, or G

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  N = A, C, T, or G

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N = A, C, T, or G

<400>  1
ngaannttcn ngaan                                                        15


<210>  2
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Leu Pro Val Gly Pro Gly Ala Ala Gly Pro Ser Asn Val Pro 
1               5                   10                  15      


Ala Phe Leu Thr Lys Leu Trp Thr Leu Val Ser Asp Pro Asp Thr Asp 
            20                  25                  30          


Ala Leu Ile Cys Trp Ser Pro Ser Gly Asn Ser Phe His Val Phe Asp 
        35                  40                  45              


Gln Gly Gln Phe Ala Lys Glu Val Leu Pro Lys Tyr Phe Lys His Asn 
    50                  55                  60                  


Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe Arg Lys 
65                  70                  75                  80  


Val Val His Ile Glu Gln Gly Gly Leu Val Lys Pro Glu Arg Asp Asp 
                85                  90                  95      


Thr Glu Phe Gln His Pro Cys Phe Leu Arg Gly Gln Glu Gln Leu Leu 
            100                 105                 110         


Glu Asn Ile Lys Arg Lys Val Thr Ser Val Ser Thr Leu Lys Ser Glu 
        115                 120                 125             


Asp Ile Lys Ile Arg Gln Asp Ser Val Thr Lys Leu Leu Thr Asp Val 
    130                 135                 140                 


Gln Leu Met Lys Gly Lys Gln Glu Cys Met Asp Ser Lys Leu Leu Ala 
145                 150                 155                 160 


Met Lys His Glu Asn Glu Ala Leu Trp Arg Glu Val Ala Ser Leu Arg 
                165                 170                 175     


Gln Lys His Ala Gln Gln Gln Lys Val Val Asn Lys Leu Ile Gln Phe 
            180                 185                 190         


Leu Ile Ser Leu Val Gln Ser Asn Arg Ile Leu Gly Val Lys Arg Lys 
        195                 200                 205             


Ile Pro Leu Met Leu Asn Asp Ser Gly Ser Ala His Ser Met Pro Lys 
    210                 215                 220                 


Tyr Ser Arg Gln Phe Ser Leu Glu His Val His Gly Ser Gly Pro Tyr 
225                 230                 235                 240 


Ser Ala Pro Ser Pro Ala Tyr Ser Ser Ser Ser Leu Tyr Ala Pro Asp 
                245                 250                 255     


Ala Val Ala Ser Ser Gly Pro Ile Ile Ser Asp Ile Thr Glu Leu Ala 
            260                 265                 270         


Pro Ala Ser Pro Met Ala Ser Pro Gly Gly Ser Ile Asp Glu Arg Pro 
        275                 280                 285             


Leu Ser Ser Ser Pro Leu Val Arg Val Lys Glu Glu Pro Pro Ser Pro 
    290                 295                 300                 


Pro Gln Ser Pro Arg Val Glu Glu Ala Ser Pro Gly Arg Pro Ser Ser 
305                 310                 315                 320 


Val Asp Thr Leu Leu Ser Pro Thr Ala Leu Ile Asp Ser Ile Leu Arg 
                325                 330                 335     


Glu Ser Glu Pro Ala Pro Ala Ser Val Thr Ala Leu Thr Asp Ala Arg 
            340                 345                 350         


Gly His Thr Asp Thr Glu Gly Arg Pro Pro Ser Pro Pro Pro Thr Ser 
        355                 360                 365             


Thr Pro Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu Leu 
    370                 375                 380                 


Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln Thr 
385                 390                 395                 400 


Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp 
                405                 410                 415     


Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu 
            420                 425                 430         


Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro 
        435                 440                 445             


Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln 
    450                 455                 460                 


Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser 
465                 470                 475                 480 


Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu 
                485                 490                 495     


Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile 
            500                 505                 510         


Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val 
        515                 520                 525             


Ser 
    


<210>  3
<211>  3142
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
    50                  55                  60                  


Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val 
65                  70                  75                  80  


Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys 
                85                  90                  95      


Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala 
            100                 105                 110         


Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala 
        115                 120                 125             


Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg 
    130                 135                 140                 


Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp 
145                 150                 155                 160 


Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys 
                165                 170                 175     


Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu 
            180                 185                 190         


Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn 
        195                 200                 205             


Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val 
    210                 215                 220                 


Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly 
225                 230                 235                 240 


Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile 
                245                 250                 255     


Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly 
            260                 265                 270         


Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr 
        275                 280                 285             


Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp 
    290                 295                 300                 


Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr 
305                 310                 315                 320 


Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly 
                325                 330                 335     


Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu 
            340                 345                 350         


Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln 
        355                 360                 365             


Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe 
    370                 375                 380                 


Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly 
385                 390                 395                 400 


Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg 
                405                 410                 415     


Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser 
            420                 425                 430         


Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu 
        435                 440                 445             


Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser 
    450                 455                 460                 


Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala 
465                 470                 475                 480 


Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr 
                485                 490                 495     


Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu 
            500                 505                 510         


Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp 
        515                 520                 525             


Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro 
    530                 535                 540                 


Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp 
545                 550                 555                 560 


Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser 
                565                 570                 575     


Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly 
            580                 585                 590         


Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile 
        595                 600                 605             


Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu 
    610                 615                 620                 


Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser 
625                 630                 635                 640 


Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro 
                645                 650                 655     


Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln 
            660                 665                 670         


Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu 
        675                 680                 685             


Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp 
    690                 695                 700                 


Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly 
705                 710                 715                 720 


Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys 
                725                 730                 735     


Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp 
            740                 745                 750         


Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr 
        755                 760                 765             


Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg 
    770                 775                 780                 


Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn 
785                 790                 795                 800 


Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys 
                805                 810                 815     


Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn 
            820                 825                 830         


Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln 
        835                 840                 845             


Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val 
    850                 855                 860                 


Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val 
865                 870                 875                 880 


Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His 
                885                 890                 895     


Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val 
            900                 905                 910         


Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala 
        915                 920                 925             


Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln 
    930                 935                 940                 


Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val 
945                 950                 955                 960 


Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser 
                965                 970                 975     


Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser 
            980                 985                 990         


Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg Val  Ile Ala Ala 
        995                 1000                 1005             


Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg Ala  Leu Thr Phe 
    1010                 1015                 1020             


Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr Ala  Phe Pro Val 
    1025                 1030                 1035             


Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val Pro  Pro Leu Ser 
    1040                 1045                 1050             


Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val Gly  Met Ala Thr 
    1055                 1060                 1065             


Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe Pro  Leu Asp Leu 
    1070                 1075                 1080             


Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly Asn  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp Ala  Ser Glu Glu 
    1100                 1105                 1110             


Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu Val  Trp Pro Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu Gln  Leu Phe Ser 
    1130                 1135                 1140             


His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His Val  Leu Asp Asp 
    1145                 1150                 1155             


Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu Pro  Ser Leu Thr 
    1160                 1165                 1170             


Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys Gly  Lys Glu Lys 
    1175                 1180                 1185             


Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser Pro  Lys Lys Gly 
    1190                 1195                 1200             


Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp Thr  Ser Gly Pro 
    1205                 1210                 1215             


Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser Phe  Tyr His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys Ala  Thr His Ala 
    1235                 1240                 1245             


Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser Thr  Glu Lys Phe 
    1250                 1255                 1260             


Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu Ser  Gln Ile Leu 
    1265                 1270                 1275             


Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys Val  Glu Glu Ile 
    1280                 1285                 1290             


Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu Pro  Met Met Ala 
    1295                 1300                 1305             


Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu Phe  Gly Thr Asn 
    1310                 1315                 1320             


Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn Pro  Ser Lys Ser 
    1325                 1330                 1335             


Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser Val  Arg Pro Gly 
    1340                 1345                 1350             


Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr His  Phe Thr Gln 
    1355                 1360                 1365             


Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val Gln  Ala Glu Gln 
    1370                 1375                 1380             


Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu Gln  Lys Val Ser 
    1385                 1390                 1395             


Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr Lys  Asn Arg Ala 
    1400                 1405                 1410             


Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu Phe  Glu Pro Leu 
    1415                 1420                 1425             


Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr Thr  Cys Val Gln 
    1430                 1435                 1440             


Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln Leu  Val Gln Leu 
    1445                 1450                 1455             


Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln Val  Phe Ile Gly 
    1460                 1465                 1470             


Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val Gly  Gln Phe Arg 
    1475                 1480                 1485             


Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe Phe  Leu Val Leu 
    1490                 1495                 1500             


Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile Ile  Gly Ile Pro 
    1505                 1510                 1515             


Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala Ser  Gly Arg Lys 
    1520                 1525                 1530             


Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro Ile  Val His Asp 
    1535                 1540                 1545             


Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp Ala  Gly Lys Glu 
    1550                 1555                 1560             


Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met Leu  Leu Arg Leu 
    1565                 1570                 1575             


Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile Leu  Val Leu Gln 
    1580                 1585                 1590             


Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys Arg  Leu Ser Arg 
    1595                 1600                 1605             


Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala Lys  Gln Gln Met 
    1610                 1615                 1620             


His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu Asn  Thr Leu Phe 
    1625                 1630                 1635             


Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val Asp  Met Leu Leu 
    1640                 1645                 1650             


Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala Ser  Val Ser Thr 
    1655                 1660                 1665             


Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile Leu  Arg Val Leu 
    1670                 1675                 1680             


Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser Arg  Ile Gln Glu 
    1685                 1690                 1695             


Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr Val  Ile Asn Arg 
    1700                 1705                 1710             


Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu Glu  His Ser Glu 
    1715                 1720                 1725             


Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr Phe  Ser Arg Phe 
    1730                 1735                 1740             


Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp Ile  Val Thr Lys 
    1745                 1750                 1755             


Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His Thr  Phe Tyr Cys 
    1760                 1765                 1770             


Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile His  Ile Phe Lys 
    1775                 1780                 1785             


Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala Thr  Arg Leu Phe 
    1790                 1795                 1800             


Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr Leu  Asp Ser Leu 
    1805                 1810                 1815             


Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His Pro  Ala Leu Val 
    1820                 1825                 1830             


Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn His  Thr Asp Tyr 
    1835                 1840                 1845             


Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys Arg  His Ser Leu 
    1850                 1855                 1860             


Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser Gly  Glu Glu Glu 
    1865                 1870                 1875             


Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys Asn  Arg Glu Ile 
    1880                 1885                 1890             


Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp Tyr  Val Cys Gln 
    1895                 1900                 1905             


Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu Ile  Val Asn His 
    1910                 1915                 1920             


Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro Pro  Val Gln Asp 
    1925                 1930                 1935             


Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala Ser  Gly Leu Phe 
    1940                 1945                 1950             


Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu Ser  Thr Pro Thr 
    1955                 1960                 1965             


Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly Ile  His Leu Ser 
    1970                 1975                 1980             


Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp Arg  Leu Leu Cys 
    1985                 1990                 1995             


Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp Ile  Leu Ala Cys 
    2000                 2005                 2010             


Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu Gln  Ser Ser Met 
    2015                 2020                 2025             


Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile Gln  Glu Tyr Leu 
    2030                 2035                 2040             


Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg Leu  Tyr Ser Leu 
    2045                 2050                 2055             


Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp Ser  Leu Ser Pro 
    2060                 2065                 2070             


Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly Asp  Gly His Val 
    2075                 2080                 2085             


Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp Tyr  Val His Leu 
    2090                 2095                 2100             


Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser Ala  Leu Leu Glu 
    2105                 2110                 2115             


Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu Asp  Met Asn Ala 
    2120                 2125                 2130             


Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu Leu  Ala Pro Cys 
    2135                 2140                 2145             


Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly Gln  Lys Ser Ala 
    2150                 2155                 2160             


Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala Arg  Val Ser Gly 
    2165                 2170                 2175             


Thr Val  Gln Gln Leu Pro Ala  Val His His Val Phe  Gln Pro Glu 
    2180                 2185                 2190             


Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys Leu  Asn Asp Leu 
    2195                 2200                 2205             


Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro Thr  Leu Ala Arg 
    2210                 2215                 2220             


Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys Leu  Pro Ser His 
    2225                 2230                 2235             


Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile Val  Lys Phe Val 
    2240                 2245                 2250             


Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu Ile  His Glu Gln 
    2255                 2260                 2265             


Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu Asp  Cys Cys Cys 
    2270                 2275                 2280             


Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val Val  Ser Ser Thr 
    2285                 2290                 2295             


Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr Cys  Val His Phe 
    2300                 2305                 2310             


Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu Gln  Leu Leu Ser 
    2315                 2320                 2325             


Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile Ser  Glu Glu Glu 
    2330                 2335                 2340             


Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys Tyr  Ile Thr Ala 
    2345                 2350                 2355             


Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser Leu  Gln Ser Val 
    2360                 2365                 2370             


Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val Pro  Ala Phe Leu 
    2375                 2380                 2385             


Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu Ala  Arg Leu Pro 
    2390                 2395                 2400             


Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu Val  Trp Lys Leu 
    2405                 2410                 2415             


Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly Thr  Ala Phe Pro 
    2420                 2425                 2430             


Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu Val  Phe Lys Glu 
    2435                 2440                 2445             


Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr Ser  Arg Thr Gln 
    2450                 2455                 2460             


Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val Leu  Val Thr Gln 
    2465                 2470                 2475             


Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro Glu  Glu Asp Thr 
    2480                 2485                 2490             


Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln Ala  Ile Thr Ser 
    2495                 2500                 2505             


Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala Gly  Asn Pro Ala 
    2510                 2515                 2520             


Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys Pro  Leu Lys Ala 
    2525                 2530                 2535             


Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile Ile  Arg Gly Ile 
    2540                 2545                 2550             


Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys Arg  Glu Asn Ile 
    2555                 2560                 2565             


Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro Val  Pro Ser Leu 
    2570                 2575                 2580             


Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His Glu  Lys Leu Leu 
    2585                 2590                 2595             


Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser Met  Ser Tyr Lys 
    2600                 2605                 2610             


Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu Gly  Asn Ser Ile 
    2615                 2620                 2625             


Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu Glu  Glu Glu Glu 
    2630                 2635                 2640             


Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr Ser  Pro Val Asn 
    2645                 2650                 2655             


Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His Ser  Cys Ser Gln 
    2660                 2665                 2670             


Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu Pro  Ser Ser Ser 
    2675                 2680                 2685             


Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu Val  Val Arg Ser 
    2690                 2695                 2700             


Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg Asn  Gln Phe Glu 
    2705                 2710                 2715             


Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg Val  His Pro Ser 
    2720                 2725                 2730             


Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro Ala  Thr Cys Lys 
    2735                 2740                 2745             


Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val Ala  Glu Pro Val 
    2750                 2755                 2760             


Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser His  Leu Pro Ser 
    2765                 2770                 2775             


Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val Leu  Glu Cys Asp 
    2780                 2785                 2790             


Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro Val  Ile Ser Asp 
    2795                 2800                 2805             


Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His Cys  Val Asn Ile 
    2810                 2815                 2820             


His Ser  Gln Gln His Val Leu  Val Met Cys Ala Thr  Ala Phe Tyr 
    2825                 2830                 2835             


Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro Glu  Phe Ser Ala 
    2840                 2845                 2850             


Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser Gly  Ser Glu Glu 
    2855                 2860                 2865             


Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu Arg  Gly Leu Glu 
    2870                 2875                 2880             


Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu Asp  Ala Glu Ser 
    2885                 2890                 2895             


Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val His  Ser Pro His 
    2900                 2905                 2910             


Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr Cys  Met Tyr Thr 
    2915                 2920                 2925             


Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser Asp  Pro Asn Pro 
    2930                 2935                 2940             


Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala Met  Glu Arg Val 
    2945                 2950                 2955             


Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe Pro  Cys Glu Ala 
    2960                 2965                 2970             


Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu Asp  Asp Phe Phe 
    2975                 2980                 2985             


Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly Glu  Phe Leu Ser 
    2990                 2995                 3000             


Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr Val  Val Tyr Lys 
    3005                 3010                 3015             


Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser Ser  Met Val Arg 
    3020                 3025                 3030             


Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr Gln  Arg Ala Pro 
    3035                 3040                 3045             


Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe Phe  Val Ser Ala 
    3050                 3055                 3060             


Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro His  Val Ile Ser 
    3065                 3070                 3075             


Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn Leu  Phe Cys Leu 
    3080                 3085                 3090             


Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu Glu  Glu Leu Asp 
    3095                 3100                 3105             


Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val Ala  Ala Pro Gly 
    3110                 3115                 3120             


Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg Asn  Val His Lys 
    3125                 3130                 3135             


Val Thr  Thr Cys Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu 
    3140         1               5                   10          


Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        15                  20                  25              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro 
    30                  35                  40                  


Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro 
45                  50                  55                  60  


Leu Leu Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
                65                  70                  75      


Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu 
            80                  85                  90          


Ser Ala Thr Lys Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu 
        95                  100                 105             


Asn Ile Val Ala Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu 
    110                 115                 120                 


Leu Gly Ile Ala Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu 
125                 130                 135                 140 


Ser Asp Val Arg Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys 
                145                 150                 155     


Ala Leu Met Asp Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys 
            160                 165                 170         


Glu Ile Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp 
        175                 180                 185             


Arg Phe Ala Glu Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro 
    190                 195                 200                 


Tyr Leu Val Asn Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro 
205                 210                 215                 220 


Glu Glu Ser Val Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met 
                225                 230                 235     


Ala Ser Phe Gly Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu 
            240                 245                 250         


Lys Ala Phe Ile Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg 
        255                 260                 265             


Thr Ala Ala Gly Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr 
    270                 275                 280                 


Gln Tyr Phe Tyr Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val 
285                 290                 295                 300 


Pro Val Glu Asp Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu 
                305                 310                 315     


Thr Leu Arg Tyr Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr 
            320                 325                 330         


Ser Leu Lys Gly Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser 
        335                 340                 345             


Pro Ser Ala Glu Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His 
    350                 355                 360                 


Thr Gln His Gln Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu 
365                 370                 375                 380 


Gln Gln Leu Phe Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr 
                385                 390                 395     


Ala Val Gly Gly Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly 
            400                 405                 410         


Gly Arg Ser Arg Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly 
        415                 420                 425             


Ser Ser Cys Ser Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu 
    430                 435                 440                 


Leu Gly Glu Glu Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp 
445                 450                 455                 460 


Val Ser Ser Ser Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly 
                465                 470                 475     


Glu Leu Ala Ala Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His 
            480                 485                 490         


Asp Ile Ile Thr Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp 
        495                 500                 505             


Ser Val Asp Leu Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly 
    510                 515                 520                 


Asp Glu Glu Asp Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val 
525                 530                 535                 540 


Pro Ser Asp Pro Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser 
                545                 550                 555     


Pro Ile Ser Asp Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala 
            560                 565                 570         


Val Thr Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn 
        575                 580                 585             


Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu 
    590                 595                 600                 


Ala Thr Gly Ile Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser 
605                 610                 615                 620 


Ser Met Ala Leu Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys 
                625                 630                 635     


Arg Gln Pro Ser Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu 
            640                 645                 650         


Ala Thr Glu Pro Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly 
        655                 660                 665             


Asp Ile Gly Gln Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys 
    670                 675                 680                 


Val Arg Leu Leu Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val 
685                 690                 695                 700 


Leu Val Pro Asp Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu 
                705                 710                 715     


Ser Cys Val Gly Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser 
            720                 725                 730         


Lys Leu Tyr Lys Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln 
        735                 740                 745             


Tyr Val Ser Asp Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val 
    750                 755                 760                 


Arg Gly Ala Thr Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu 
765                 770                 775                 780 


Ser Arg Ser Arg Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr 
                785                 790                 795     


Leu Thr Gly Asn Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg 
            800                 805                 810         


Lys Thr Leu Lys Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr 
        815                 820                 825             


Ala Val Arg Asn Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu 
    830                 835                 840                 


Leu Gly Leu Gln Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser 
845                 850                 855                 860 


Tyr Trp Leu Val Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp 
                865                 870                 875     


Phe Arg Leu Val Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg 
            880                 885                 890         


Gly Ala His His Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu 
        895                 900                 905             


Asn Asn Val Val Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg 
    910                 915                 920                 


His Val Ala Ala Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr 
925                 930                 935                 940 


Lys Cys Asp Gln Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp 
                945                 950                 955     


Gln Ser Ser Val Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro 
            960                 965                 970         


Ser His Phe Ser Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn 
        975                 980                 985             


Leu Leu Pro Ser Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg 
    990                 995                 1000                 


Val  Ile Ala Ala Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg 
1005                 1010                 1015                 


Ala  Leu Thr Phe Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr 
1020                 1025                 1030                 


Ala  Phe Pro Val Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val 
1035                 1040                 1045                 


Pro  Pro Leu Ser Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val 
1050                 1055                 1060                 


Gly  Met Ala Thr Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe 
1065                 1070                 1075                 


Pro  Leu Asp Leu Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly 
1080                 1085                 1090                 


Asn  Leu Leu Ala Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp 
1095                 1100                 1105                 


Ala  Ser Glu Glu Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu 
1110                 1115                 1120                 


Val  Trp Pro Ala Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu 
1125                 1130                 1135                 


Gln  Leu Phe Ser His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His 
1140                 1145                 1150                 


Val  Leu Asp Asp Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu 
1155                 1160                 1165                 


Pro  Ser Leu Thr Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys 
1170                 1175                 1180                 


Gly  Lys Glu Lys Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser 
1185                 1190                 1195                 


Pro  Lys Lys Gly Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp 
1200                 1205                 1210                 


Thr  Ser Gly Pro Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser 
1215                 1220                 1225                 


Phe  Tyr His Leu Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys 
1230                 1235                 1240                 


Ala  Thr His Ala Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser 
1245                 1250                 1255                 


Thr  Glu Lys Phe Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu 
1260                 1265                 1270                 


Ser  Gln Ile Leu Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys 
1275                 1280                 1285                 


Val  Glu Glu Ile Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu 
1290                 1295                 1300                 


Pro  Met Met Ala Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu 
1305                 1310                 1315                 


Phe  Gly Thr Asn Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn 
1320                 1325                 1330                 


Pro  Ser Lys Ser Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser 
1335                 1340                 1345                 


Val  Arg Pro Gly Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr 
1350                 1355                 1360                 


His  Phe Thr Gln Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val 
1365                 1370                 1375                 


Gln  Ala Glu Gln Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu 
1380                 1385                 1390                 


Gln  Lys Val Ser Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr 
1395                 1400                 1405                 


Lys  Asn Arg Ala Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu 
1410                 1415                 1420                 


Phe  Glu Pro Leu Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr 
1425                 1430                 1435                 


Thr  Cys Val Gln Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln 
1440                 1445                 1450                 


Leu  Val Gln Leu Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln 
1455                 1460                 1465                 


Val  Phe Ile Gly Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val 
1470                 1475                 1480                 


Gly  Gln Phe Arg Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe 
1485                 1490                 1495                 


Phe  Leu Val Leu Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile 
1500                 1505                 1510                 


Ile  Gly Ile Pro Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala 
1515                 1520                 1525                 


Ser  Gly Arg Lys Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro 
1530                 1535                 1540                 


Ile  Val His Asp Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp 
1545                 1550                 1555                 


Ala  Gly Lys Glu Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met 
1560                 1565                 1570                 


Leu  Leu Arg Leu Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile 
1575                 1580                 1585                 


Leu  Val Leu Gln Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys 
1590                 1595                 1600                 


Arg  Leu Ser Arg Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala 
1605                 1610                 1615                 


Lys  Gln Gln Met His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu 
1620                 1625                 1630                 


Asn  Thr Leu Phe Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val 
1635                 1640                 1645                 


Asp  Met Leu Leu Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala 
1650                 1655                 1660                 


Ser  Val Ser Thr Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile 
1665                 1670                 1675                 


Leu  Arg Val Leu Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser 
1680                 1685                 1690                 


Arg  Ile Gln Glu Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr 
1695                 1700                 1705                 


Val  Ile Asn Arg Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu 
1710                 1715                 1720                 


Glu  His Ser Glu Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr 
1725                 1730                 1735                 


Phe  Ser Arg Phe Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp 
1740                 1745                 1750                 


Ile  Val Thr Lys Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His 
1755                 1760                 1765                 


Thr  Phe Tyr Cys Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile 
1770                 1775                 1780                 


His  Ile Phe Lys Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala 
1785                 1790                 1795                 


Thr  Arg Leu Phe Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr 
1800                 1805                 1810                 


Leu  Asp Ser Leu Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His 
1815                 1820                 1825                 


Pro  Ala Leu Val Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn 
1830                 1835                 1840                 


His  Thr Asp Tyr Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys 
1845                 1850                 1855                 


Arg  His Ser Leu Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser 
1860                 1865                 1870                 


Gly  Glu Glu Glu Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys 
1875                 1880                 1885                 


Asn  Arg Glu Ile Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp 
1890                 1895                 1900                 


Tyr  Val Cys Gln Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu 
1905                 1910                 1915                 


Ile  Val Asn His Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro 
1920                 1925                 1930                 


Pro  Val Gln Asp Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala 
1935                 1940                 1945                 


Ser  Gly Leu Phe Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu 
1950                 1955                 1960                 


Ser  Thr Pro Thr Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly 
1965                 1970                 1975                 


Ile  His Leu Ser Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp 
1980                 1985                 1990                 


Arg  Leu Leu Cys Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp 
1995                 2000                 2005                 


Ile  Leu Ala Cys Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu 
2010                 2015                 2020                 


Gln  Ser Ser Met Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile 
2025                 2030                 2035                 


Gln  Glu Tyr Leu Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg 
2040                 2045                 2050                 


Leu  Tyr Ser Leu Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp 
2055                 2060                 2065                 


Ser  Leu Ser Pro Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly 
2070                 2075                 2080                 


Asp  Gly His Val Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp 
2085                 2090                 2095                 


Tyr  Val His Leu Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser 
2100                 2105                 2110                 


Ala  Leu Leu Glu Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu 
2115                 2120                 2125                 


Asp  Met Asn Ala Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu 
2130                 2135                 2140                 


Leu  Ala Pro Cys Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly 
2145                 2150                 2155                 


Gln  Lys Ser Ala Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala 
2160                 2165                 2170                 


Arg  Val Ser Gly Thr Val  Gln Gln Leu Pro Ala  Val His His Val 
2175                 2180                 2185                 


Phe  Gln Pro Glu Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys 
2190                 2195                 2200                 


Leu  Asn Asp Leu Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro 
2205                 2210                 2215                 


Thr  Leu Ala Arg Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys 
2220                 2225                 2230                 


Leu  Pro Ser His Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile 
2235                 2240                 2245                 


Val  Lys Phe Val Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu 
2250                 2255                 2260                 


Ile  His Glu Gln Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu 
2265                 2270                 2275                 


Asp  Cys Cys Cys Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val 
2280                 2285                 2290                 


Val  Ser Ser Thr Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr 
2295                 2300                 2305                 


Cys  Val His Phe Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu 
2310                 2315                 2320                 


Gln  Leu Leu Ser Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile 
2325                 2330                 2335                 


Ser  Glu Glu Glu Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys 
2340                 2345                 2350                 


Tyr  Ile Thr Ala Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser 
2355                 2360                 2365                 


Leu  Gln Ser Val Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val 
2370                 2375                 2380                 


Pro  Ala Phe Leu Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu 
2385                 2390                 2395                 


Ala  Arg Leu Pro Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu 
2400                 2405                 2410                 


Val  Trp Lys Leu Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly 
2415                 2420                 2425                 


Thr  Ala Phe Pro Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu 
2430                 2435                 2440                 


Val  Phe Lys Glu Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr 
2445                 2450                 2455                 


Ser  Arg Thr Gln Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val 
2460                 2465                 2470                 


Leu  Val Thr Gln Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro 
2475                 2480                 2485                 


Glu  Glu Asp Thr Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln 
2490                 2495                 2500                 


Ala  Ile Thr Ser Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala 
2505                 2510                 2515                 


Gly  Asn Pro Ala Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys 
2520                 2525                 2530                 


Pro  Leu Lys Ala Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile 
2535                 2540                 2545                 


Ile  Arg Gly Ile Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys 
2550                 2555                 2560                 


Arg  Glu Asn Ile Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro 
2565                 2570                 2575                 


Val  Pro Ser Leu Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His 
2580                 2585                 2590                 


Glu  Lys Leu Leu Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser 
2595                 2600                 2605                 


Met  Ser Tyr Lys Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu 
2610                 2615                 2620                 


Gly  Asn Ser Ile Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu 
2625                 2630                 2635                 


Glu  Glu Glu Glu Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr 
2640                 2645                 2650                 


Ser  Pro Val Asn Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His 
2655                 2660                 2665                 


Ser  Cys Ser Gln Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu 
2670                 2675                 2680                 


Pro  Ser Ser Ser Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu 
2685                 2690                 2695                 


Val  Val Arg Ser Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg 
2700                 2705                 2710                 


Asn  Gln Phe Glu Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg 
2715                 2720                 2725                 


Val  His Pro Ser Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro 
2730                 2735                 2740                 


Ala  Thr Cys Lys Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val 
2745                 2750                 2755                 


Ala  Glu Pro Val Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser 
2760                 2765                 2770                 


His  Leu Pro Ser Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val 
2775                 2780                 2785                 


Leu  Glu Cys Asp Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro 
2790                 2795                 2800                 


Val  Ile Ser Asp Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His 
2805                 2810                 2815                 


Cys  Val Asn Ile His Ser  Gln Gln His Val Leu  Val Met Cys Ala 
2820                 2825                 2830                 


Thr  Ala Phe Tyr Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro 
2835                 2840                 2845                 


Glu  Phe Ser Ala Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser 
2850                 2855                 2860                 


Gly  Ser Glu Glu Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu 
2865                 2870                 2875                 


Arg  Gly Leu Glu Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu 
2880                 2885                 2890                 


Asp  Ala Glu Ser Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val 
2895                 2900                 2905                 


His  Ser Pro His Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr 
2910                 2915                 2920                 


Cys  Met Tyr Thr Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser 
2925                 2930                 2935                 


Asp  Pro Asn Pro Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala 
2940                 2945                 2950                 


Met  Glu Arg Val Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe 
2955                 2960                 2965                 


Pro  Cys Glu Ala Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu 
2970                 2975                 2980                 


Asp  Asp Phe Phe Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly 
2985                 2990                 2995                 


Glu  Phe Leu Ser Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr 
3000                 3005                 3010                 


Val  Val Tyr Lys Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser 
3015                 3020                 3025                 


Ser  Met Val Arg Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr 
3030                 3035                 3040                 


Gln  Arg Ala Pro Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe 
3045                 3050                 3055                 


Phe  Val Ser Ala Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro 
3060                 3065                 3070                 


His  Val Ile Ser Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn 
3075                 3080                 3085                 


Leu  Phe Cys Leu Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu 
3090                 3095                 3100                 


Glu  Glu Leu Asp Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val 
3105                 3110                 3115                 


Ala  Ala Pro Gly Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg 
3120                 3125                 3130                 


Asn  Val His Lys Val Thr  Thr Cys Met Ala Thr Leu Glu Lys Leu Met 
3135                 3140         1               5               


Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln Gln Gln Gln Gln Gln Gln 
    10                  15                  20                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro 
25                  30                  35                  40  


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro 
                45                  50                  55      


Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro 
            60                  65                  70          


Pro Pro Pro Pro Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro 
        75                  80                  85              


Lys Lys Glu Leu Ser Ala Thr Lys Lys Asp Arg Val Asn His Cys Leu 
    90                  95                  100                 


Thr Ile Cys Glu Asn Ile Val Ala Gln Ser Val Arg Asn Ser Pro Glu 
105                 110                 115                 120 


Phe Gln Lys Leu Leu Gly Ile Ala Met Glu Leu Phe Leu Leu Cys Ser 
                125                 130                 135     


Asp Asp Ala Glu Ser Asp Val Arg Met Val Ala Asp Glu Cys Leu Asn 
            140                 145                 150         


Lys Val Ile Lys Ala Leu Met Asp Ser Asn Leu Pro Arg Leu Gln Leu 
        155                 160                 165             


Glu Leu Tyr Lys Glu Ile Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg 
    170                 175                 180                 


Ala Ala Leu Trp Arg Phe Ala Glu Leu Ala His Leu Val Arg Pro Gln 
185                 190                 195                 200 


Lys Cys Arg Pro Tyr Leu Val Asn Leu Leu Pro Cys Leu Thr Arg Thr 
                205                 210                 215     


Ser Lys Arg Pro Glu Glu Ser Val Gln Glu Thr Leu Ala Ala Ala Val 
            220                 225                 230         


Pro Lys Ile Met Ala Ser Phe Gly Asn Phe Ala Asn Asp Asn Glu Ile 
        235                 240                 245             


Lys Val Leu Leu Lys Ala Phe Ile Ala Asn Leu Lys Ser Ser Ser Pro 
    250                 255                 260                 


Thr Ile Arg Arg Thr Ala Ala Gly Ser Ala Val Ser Ile Cys Gln His 
265                 270                 275                 280 


Ser Arg Arg Thr Gln Tyr Phe Tyr Ser Trp Leu Leu Asn Val Leu Leu 
                285                 290                 295     


Gly Leu Leu Val Pro Val Glu Asp Glu His Ser Thr Leu Leu Ile Leu 
            300                 305                 310         


Gly Val Leu Leu Thr Leu Arg Tyr Leu Val Pro Leu Leu Gln Gln Gln 
        315                 320                 325             


Val Lys Asp Thr Ser Leu Lys Gly Ser Phe Gly Val Thr Arg Lys Glu 
    330                 335                 340                 


Met Glu Val Ser Pro Ser Ala Glu Gln Leu Val Gln Val Tyr Glu Leu 
345                 350                 355                 360 


Thr Leu His His Thr Gln His Gln Asp His Asn Val Val Thr Gly Ala 
                365                 370                 375     


Leu Glu Leu Leu Gln Gln Leu Phe Arg Thr Pro Pro Pro Glu Leu Leu 
            380                 385                 390         


Gln Thr Leu Thr Ala Val Gly Gly Ile Gly Gln Leu Thr Ala Ala Lys 
        395                 400                 405             


Glu Glu Ser Gly Gly Arg Ser Arg Ser Gly Ser Ile Val Glu Leu Ile 
    410                 415                 420                 


Ala Gly Gly Gly Ser Ser Cys Ser Pro Val Leu Ser Arg Lys Gln Lys 
425                 430                 435                 440 


Gly Lys Val Leu Leu Gly Glu Glu Glu Ala Leu Glu Asp Asp Ser Glu 
                445                 450                 455     


Ser Arg Ser Asp Val Ser Ser Ser Ala Leu Thr Ala Ser Val Lys Asp 
            460                 465                 470         


Glu Ile Ser Gly Glu Leu Ala Ala Ser Ser Gly Val Ser Thr Pro Gly 
        475                 480                 485             


Ser Ala Gly His Asp Ile Ile Thr Glu Gln Pro Arg Ser Gln His Thr 
    490                 495                 500                 


Leu Gln Ala Asp Ser Val Asp Leu Ala Ser Cys Asp Leu Thr Ser Ser 
505                 510                 515                 520 


Ala Thr Asp Gly Asp Glu Glu Asp Ile Leu Ser His Ser Ser Ser Gln 
                525                 530                 535     


Val Ser Ala Val Pro Ser Asp Pro Ala Met Asp Leu Asn Asp Gly Thr 
            540                 545                 550         


Gln Ala Ser Ser Pro Ile Ser Asp Ser Ser Gln Thr Thr Thr Glu Gly 
        555                 560                 565             


Pro Asp Ser Ala Val Thr Pro Ser Asp Ser Ser Glu Ile Val Leu Asp 
    570                 575                 580                 


Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp 
585                 590                 595                 600 


Glu Asp Glu Glu Ala Thr Gly Ile Leu Pro Asp Glu Ala Ser Glu Ala 
                605                 610                 615     


Phe Arg Asn Ser Ser Met Ala Leu Gln Gln Ala His Leu Leu Lys Asn 
            620                 625                 630         


Met Ser His Cys Arg Gln Pro Ser Asp Ser Ser Val Asp Lys Phe Val 
        635                 640                 645             


Leu Arg Asp Glu Ala Thr Glu Pro Gly Asp Gln Glu Asn Lys Pro Cys 
    650                 655                 660                 


Arg Ile Lys Gly Asp Ile Gly Gln Ser Thr Asp Asp Asp Ser Ala Pro 
665                 670                 675                 680 


Leu Val His Cys Val Arg Leu Leu Ser Ala Ser Phe Leu Leu Thr Gly 
                685                 690                 695     


Gly Lys Asn Val Leu Val Pro Asp Arg Asp Val Arg Val Ser Val Lys 
            700                 705                 710         


Ala Leu Ala Leu Ser Cys Val Gly Ala Ala Val Ala Leu His Pro Glu 
        715                 720                 725             


Ser Phe Phe Ser Lys Leu Tyr Lys Val Pro Leu Asp Thr Thr Glu Tyr 
    730                 735                 740                 


Pro Glu Glu Gln Tyr Val Ser Asp Ile Leu Asn Tyr Ile Asp His Gly 
745                 750                 755                 760 


Asp Pro Gln Val Arg Gly Ala Thr Ala Ile Leu Cys Gly Thr Leu Ile 
                765                 770                 775     


Cys Ser Ile Leu Ser Arg Ser Arg Phe His Val Gly Asp Trp Met Gly 
            780                 785                 790         


Thr Ile Arg Thr Leu Thr Gly Asn Thr Phe Ser Leu Ala Asp Cys Ile 
        795                 800                 805             


Pro Leu Leu Arg Lys Thr Leu Lys Asp Glu Ser Ser Val Thr Cys Lys 
    810                 815                 820                 


Leu Ala Cys Thr Ala Val Arg Asn Cys Val Met Ser Leu Cys Ser Ser 
825                 830                 835                 840 


Ser Tyr Ser Glu Leu Gly Leu Gln Leu Ile Ile Asp Val Leu Thr Leu 
                845                 850                 855     


Arg Asn Ser Ser Tyr Trp Leu Val Arg Thr Glu Leu Leu Glu Thr Leu 
            860                 865                 870         


Ala Glu Ile Asp Phe Arg Leu Val Ser Phe Leu Glu Ala Lys Ala Glu 
        875                 880                 885             


Asn Leu His Arg Gly Ala His His Tyr Thr Gly Leu Leu Lys Leu Gln 
    890                 895                 900                 


Glu Arg Val Leu Asn Asn Val Val Ile His Leu Leu Gly Asp Glu Asp 
905                 910                 915                 920 


Pro Arg Val Arg His Val Ala Ala Ala Ser Leu Ile Arg Leu Val Pro 
                925                 930                 935     


Lys Leu Phe Tyr Lys Cys Asp Gln Gly Gln Ala Asp Pro Val Val Ala 
            940                 945                 950         


Val Ala Arg Asp Gln Ser Ser Val Tyr Leu Lys Leu Leu Met His Glu 
        955                 960                 965             


Thr Gln Pro Pro Ser His Phe Ser Val Ser Thr Ile Thr Arg Ile Tyr 
    970                 975                 980                 


Arg Gly Tyr Asn Leu Leu Pro Ser Ile Thr Asp Val Thr Met Glu Asn  
985                 990                 995                 1000 


Asn Leu Ser Arg Val  Ile Ala Ala Val Ser  His Glu Leu Ile Thr  
                1005                 1010                 1015 


Ser Thr Thr Arg Ala  Leu Thr Phe Gly Cys  Cys Glu Ala Leu Cys  
                1020                 1025                 1030 


Leu Leu Ser Thr Ala  Phe Pro Val Cys Ile  Trp Ser Leu Gly Trp  
                1035                 1040                 1045 


His Cys Gly Val Pro  Pro Leu Ser Ala Ser  Asp Glu Ser Arg Lys  
                1050                 1055                 1060 


Ser Cys Thr Val Gly  Met Ala Thr Met Ile  Leu Thr Leu Leu Ser  
                1065                 1070                 1075 


Ser Ala Trp Phe Pro  Leu Asp Leu Ser Ala  His Gln Asp Ala Leu  
                1080                 1085                 1090 


Ile Leu Ala Gly Asn  Leu Leu Ala Ala Ser  Ala Pro Lys Ser Leu  
                1095                 1100                 1105 


Arg Ser Ser Trp Ala  Ser Glu Glu Glu Ala  Asn Pro Ala Ala Thr  
                1110                 1115                 1120 


Lys Gln Glu Glu Val  Trp Pro Ala Leu Gly  Asp Arg Ala Leu Val  
                1125                 1130                 1135 


Pro Met Val Glu Gln  Leu Phe Ser His Leu  Leu Lys Val Ile Asn  
                1140                 1145                 1150 


Ile Cys Ala His Val  Leu Asp Asp Val Ala  Pro Gly Pro Ala Ile  
                1155                 1160                 1165 


Lys Ala Ala Leu Pro  Ser Leu Thr Asn Pro  Pro Ser Leu Ser Pro  
                1170                 1175                 1180 


Ile Arg Arg Lys Gly  Lys Glu Lys Glu Pro  Gly Glu Gln Ala Ser  
                1185                 1190                 1195 


Val Pro Leu Ser Pro  Lys Lys Gly Ser Glu  Ala Ser Ala Ala Ser  
                1200                 1205                 1210 


Arg Gln Ser Asp Thr  Ser Gly Pro Val Thr  Thr Ser Lys Ser Ser  
                1215                 1220                 1225 


Ser Leu Gly Ser Phe  Tyr His Leu Pro Ser  Tyr Leu Lys Leu His  
                1230                 1235                 1240 


Asp Val Leu Lys Ala  Thr His Ala Asn Tyr  Lys Val Thr Leu Asp  
                1245                 1250                 1255 


Leu Gln Asn Ser Thr  Glu Lys Phe Gly Gly  Phe Leu Arg Ser Ala  
                1260                 1265                 1270 


Leu Asp Val Leu Ser  Gln Ile Leu Glu Leu  Ala Thr Leu Gln Asp  
                1275                 1280                 1285 


Ile Gly Lys Cys Val  Glu Glu Ile Leu Gly  Tyr Leu Lys Ser Cys  
                1290                 1295                 1300 


Phe Ser Arg Glu Pro  Met Met Ala Thr Val  Cys Val Gln Gln Leu  
                1305                 1310                 1315 


Leu Lys Thr Leu Phe  Gly Thr Asn Leu Ala  Ser Gln Phe Asp Gly  
                1320                 1325                 1330 


Leu Ser Ser Asn Pro  Ser Lys Ser Gln Gly  Arg Ala Gln Arg Leu  
                1335                 1340                 1345 


Gly Ser Ser Ser Val  Arg Pro Gly Leu Tyr  His Tyr Cys Phe Met  
                1350                 1355                 1360 


Ala Pro Tyr Thr His  Phe Thr Gln Ala Leu  Ala Asp Ala Ser Leu  
                1365                 1370                 1375 


Arg Asn Met Val Gln  Ala Glu Gln Glu Asn  Asp Thr Ser Gly Trp  
                1380                 1385                 1390 


Phe Asp Val Leu Gln  Lys Val Ser Thr Gln  Leu Lys Thr Asn Leu  
                1395                 1400                 1405 


Thr Ser Val Thr Lys  Asn Arg Ala Asp Lys  Asn Ala Ile His Asn  
                1410                 1415                 1420 


His Ile Arg Leu Phe  Glu Pro Leu Val Ile  Lys Ala Leu Lys Gln  
                1425                 1430                 1435 


Tyr Thr Thr Thr Thr  Cys Val Gln Leu Gln  Lys Gln Val Leu Asp  
                1440                 1445                 1450 


Leu Leu Ala Gln Leu  Val Gln Leu Arg Val  Asn Tyr Cys Leu Leu  
                1455                 1460                 1465 


Asp Ser Asp Gln Val  Phe Ile Gly Phe Val  Leu Lys Gln Phe Glu  
                1470                 1475                 1480 


Tyr Ile Glu Val Gly  Gln Phe Arg Glu Ser  Glu Ala Ile Ile Pro  
                1485                 1490                 1495 


Asn Ile Phe Phe Phe  Leu Val Leu Leu Ser  Tyr Glu Arg Tyr His  
                1500                 1505                 1510 


Ser Lys Gln Ile Ile  Gly Ile Pro Lys Ile  Ile Gln Leu Cys Asp  
                1515                 1520                 1525 


Gly Ile Met Ala Ser  Gly Arg Lys Ala Val  Thr His Ala Ile Pro  
                1530                 1535                 1540 


Ala Leu Gln Pro Ile  Val His Asp Leu Phe  Val Leu Arg Gly Thr  
                1545                 1550                 1555 


Asn Lys Ala Asp Ala  Gly Lys Glu Leu Glu  Thr Gln Lys Glu Val  
                1560                 1565                 1570 


Val Val Ser Met Leu  Leu Arg Leu Ile Gln  Tyr His Gln Val Leu  
                1575                 1580                 1585 


Glu Met Phe Ile Leu  Val Leu Gln Gln Cys  His Lys Glu Asn Glu  
                1590                 1595                 1600 


Asp Lys Trp Lys Arg  Leu Ser Arg Gln Ile  Ala Asp Ile Ile Leu  
                1605                 1610                 1615 


Pro Met Leu Ala Lys  Gln Gln Met His Ile  Asp Ser His Glu Ala  
                1620                 1625                 1630 


Leu Gly Val Leu Asn  Thr Leu Phe Glu Ile  Leu Ala Pro Ser Ser  
                1635                 1640                 1645 


Leu Arg Pro Val Asp  Met Leu Leu Arg Ser  Met Phe Val Thr Pro  
                1650                 1655                 1660 


Asn Thr Met Ala Ser  Val Ser Thr Val Gln  Leu Trp Ile Ser Gly  
                1665                 1670                 1675 


Ile Leu Ala Ile Leu  Arg Val Leu Ile Ser  Gln Ser Thr Glu Asp  
                1680                 1685                 1690 


Ile Val Leu Ser Arg  Ile Gln Glu Leu Ser  Phe Ser Pro Tyr Leu  
                1695                 1700                 1705 


Ile Ser Cys Thr Val  Ile Asn Arg Leu Arg  Asp Gly Asp Ser Thr  
                1710                 1715                 1720 


Ser Thr Leu Glu Glu  His Ser Glu Gly Lys  Gln Ile Lys Asn Leu  
                1725                 1730                 1735 


Pro Glu Glu Thr Phe  Ser Arg Phe Leu Leu  Gln Leu Val Gly Ile  
                1740                 1745                 1750 


Leu Leu Glu Asp Ile  Val Thr Lys Gln Leu  Lys Val Glu Met Ser  
                1755                 1760                 1765 


Glu Gln Gln His Thr  Phe Tyr Cys Gln Glu  Leu Gly Thr Leu Leu  
                1770                 1775                 1780 


Met Cys Leu Ile His  Ile Phe Lys Ser Gly  Met Phe Arg Arg Ile  
                1785                 1790                 1795 


Thr Ala Ala Ala Thr  Arg Leu Phe Arg Ser  Asp Gly Cys Gly Gly  
                1800                 1805                 1810 


Ser Phe Tyr Thr Leu  Asp Ser Leu Asn Leu  Arg Ala Arg Ser Met  
                1815                 1820                 1825 


Ile Thr Thr His Pro  Ala Leu Val Leu Leu  Trp Cys Gln Ile Leu  
                1830                 1835                 1840 


Leu Leu Val Asn His  Thr Asp Tyr Arg Trp  Trp Ala Glu Val Gln  
                1845                 1850                 1855 


Gln Thr Pro Lys Arg  His Ser Leu Ser Ser  Thr Lys Leu Leu Ser  
                1860                 1865                 1870 


Pro Gln Met Ser Gly  Glu Glu Glu Asp Ser  Asp Leu Ala Ala Lys  
                1875                 1880                 1885 


Leu Gly Met Cys Asn  Arg Glu Ile Val Arg  Arg Gly Ala Leu Ile  
                1890                 1895                 1900 


Leu Phe Cys Asp Tyr  Val Cys Gln Asn Leu  His Asp Ser Glu His  
                1905                 1910                 1915 


Leu Thr Trp Leu Ile  Val Asn His Ile Gln  Asp Leu Ile Ser Leu  
                1920                 1925                 1930 


Ser His Glu Pro Pro  Val Gln Asp Phe Ile  Ser Ala Val His Arg  
                1935                 1940                 1945 


Asn Ser Ala Ala Ser  Gly Leu Phe Ile Gln  Ala Ile Gln Ser Arg  
                1950                 1955                 1960 


Cys Glu Asn Leu Ser  Thr Pro Thr Met Leu  Lys Lys Thr Leu Gln  
                1965                 1970                 1975 


Cys Leu Glu Gly Ile  His Leu Ser Gln Ser  Gly Ala Val Leu Thr  
                1980                 1985                 1990 


Leu Tyr Val Asp Arg  Leu Leu Cys Thr Pro  Phe Arg Val Leu Ala  
                1995                 2000                 2005 


Arg Met Val Asp Ile  Leu Ala Cys Arg Arg  Val Glu Met Leu Leu  
                2010                 2015                 2020 


Ala Ala Asn Leu Gln  Ser Ser Met Ala Gln  Leu Pro Met Glu Glu  
                2025                 2030                 2035 


Leu Asn Arg Ile Gln  Glu Tyr Leu Gln Ser  Ser Gly Leu Ala Gln  
                2040                 2045                 2050 


Arg His Gln Arg Leu  Tyr Ser Leu Leu Asp  Arg Phe Arg Leu Ser  
                2055                 2060                 2065 


Thr Met Gln Asp Ser  Leu Ser Pro Ser Pro  Pro Val Ser Ser His  
                2070                 2075                 2080 


Pro Leu Asp Gly Asp  Gly His Val Ser Leu  Glu Thr Val Ser Pro  
                2085                 2090                 2095 


Asp Lys Asp Trp Tyr  Val His Leu Val Lys  Ser Gln Cys Trp Thr  
                2100                 2105                 2110 


Arg Ser Asp Ser Ala  Leu Leu Glu Gly Ala  Glu Leu Val Asn Arg  
                2115                 2120                 2125 


Ile Pro Ala Glu Asp  Met Asn Ala Phe Met  Met Asn Ser Glu Phe  
                2130                 2135                 2140 


Asn Leu Ser Leu Leu  Ala Pro Cys Leu Ser  Leu Gly Met Ser Glu  
                2145                 2150                 2155 


Ile Ser Gly Gly Gln  Lys Ser Ala Leu Phe  Glu Ala Ala Arg Glu  
                2160                 2165                 2170 


Val Thr Leu Ala Arg  Val Ser Gly Thr Val  Gln Gln Leu Pro Ala  
                2175                 2180                 2185 


Val His His Val Phe  Gln Pro Glu Leu Pro  Ala Glu Pro Ala Ala  
                2190                 2195                 2200 


Tyr Trp Ser Lys Leu  Asn Asp Leu Phe Gly  Asp Ala Ala Leu Tyr  
                2205                 2210                 2215 


Gln Ser Leu Pro Thr  Leu Ala Arg Ala Leu  Ala Gln Tyr Leu Val  
                2220                 2225                 2230 


Val Val Ser Lys Leu  Pro Ser His Leu His  Leu Pro Pro Glu Lys  
                2235                 2240                 2245 


Glu Lys Asp Ile Val  Lys Phe Val Val Ala  Thr Leu Glu Ala Leu  
                2250                 2255                 2260 


Ser Trp His Leu Ile  His Glu Gln Ile Pro  Leu Ser Leu Asp Leu  
                2265                 2270                 2275 


Gln Ala Gly Leu Asp  Cys Cys Cys Leu Ala  Leu Gln Leu Pro Gly  
                2280                 2285                 2290 


Leu Trp Ser Val Val  Ser Ser Thr Glu Phe  Val Thr His Ala Cys  
                2295                 2300                 2305 


Ser Leu Ile Tyr Cys  Val His Phe Ile Leu  Glu Ala Val Ala Val  
                2310                 2315                 2320 


Gln Pro Gly Glu Gln  Leu Leu Ser Pro Glu  Arg Arg Thr Asn Thr  
                2325                 2330                 2335 


Pro Lys Ala Ile Ser  Glu Glu Glu Glu Glu  Val Asp Pro Asn Thr  
                2340                 2345                 2350 


Gln Asn Pro Lys Tyr  Ile Thr Ala Ala Cys  Glu Met Val Ala Glu  
                2355                 2360                 2365 


Met Val Glu Ser Leu  Gln Ser Val Leu Ala  Leu Gly His Lys Arg  
                2370                 2375                 2380 


Asn Ser Gly Val Pro  Ala Phe Leu Thr Pro  Leu Leu Arg Asn Ile  
                2385                 2390                 2395 


Ile Ile Ser Leu Ala  Arg Leu Pro Leu Val  Asn Ser Tyr Thr Arg  
                2400                 2405                 2410 


Val Pro Pro Leu Val  Trp Lys Leu Gly Trp  Ser Pro Lys Pro Gly  
                2415                 2420                 2425 


Gly Asp Phe Gly Thr  Ala Phe Pro Glu Ile  Pro Val Glu Phe Leu  
                2430                 2435                 2440 


Gln Glu Lys Glu Val  Phe Lys Glu Phe Ile  Tyr Arg Ile Asn Thr  
                2445                 2450                 2455 


Leu Gly Trp Thr Ser  Arg Thr Gln Phe Glu  Glu Thr Trp Ala Thr  
                2460                 2465                 2470 


Leu Leu Gly Val Leu  Val Thr Gln Pro Leu  Val Met Glu Gln Glu  
                2475                 2480                 2485 


Glu Ser Pro Pro Glu  Glu Asp Thr Glu Arg  Thr Gln Ile Asn Val  
                2490                 2495                 2500 


Leu Ala Val Gln Ala  Ile Thr Ser Leu Val  Leu Ser Ala Met Thr  
                2505                 2510                 2515 


Val Pro Val Ala Gly  Asn Pro Ala Val Ser  Cys Leu Glu Gln Gln  
                2520                 2525                 2530 


Pro Arg Asn Lys Pro  Leu Lys Ala Leu Asp  Thr Arg Phe Gly Arg  
                2535                 2540                 2545 


Lys Leu Ser Ile Ile  Arg Gly Ile Val Glu  Gln Glu Ile Gln Ala  
                2550                 2555                 2560 


Met Val Ser Lys Arg  Glu Asn Ile Ala Thr  His His Leu Tyr Gln  
                2565                 2570                 2575 


Ala Trp Asp Pro Val  Pro Ser Leu Ser Pro  Ala Thr Thr Gly Ala  
                2580                 2585                 2590 


Leu Ile Ser His Glu  Lys Leu Leu Leu Gln  Ile Asn Pro Glu Arg  
                2595                 2600                 2605 


Glu Leu Gly Ser Met  Ser Tyr Lys Leu Gly  Gln Val Ser Ile His  
                2610                 2615                 2620 


Ser Val Trp Leu Gly  Asn Ser Ile Thr Pro  Leu Arg Glu Glu Glu  
                2625                 2630                 2635 


Trp Asp Glu Glu Glu  Glu Glu Glu Ala Asp  Ala Pro Ala Pro Ser  
                2640                 2645                 2650 


Ser Pro Pro Thr Ser  Pro Val Asn Ser Arg  Lys His Arg Ala Gly  
                2655                 2660                 2665 


Val Asp Ile His Ser  Cys Ser Gln Phe Leu  Leu Glu Leu Tyr Ser  
                2670                 2675                 2680 


Arg Trp Ile Leu Pro  Ser Ser Ser Ala Arg  Arg Thr Pro Ala Ile  
                2685                 2690                 2695 


Leu Ile Ser Glu Val  Val Arg Ser Leu Leu  Val Val Ser Asp Leu  
                2700                 2705                 2710 


Phe Thr Glu Arg Asn  Gln Phe Glu Leu Met  Tyr Val Thr Leu Thr  
                2715                 2720                 2725 


Glu Leu Arg Arg Val  His Pro Ser Glu Asp  Glu Ile Leu Ala Gln  
                2730                 2735                 2740 


Tyr Leu Val Pro Ala  Thr Cys Lys Ala Ala  Ala Val Leu Gly Met  
                2745                 2750                 2755 


Asp Lys Ala Val Ala  Glu Pro Val Ser Arg  Leu Leu Glu Ser Thr  
                2760                 2765                 2770 


Leu Arg Ser Ser His  Leu Pro Ser Arg Val  Gly Ala Leu His Gly  
                2775                 2780                 2785 


Val Leu Tyr Val Leu  Glu Cys Asp Leu Leu  Asp Asp Thr Ala Lys  
                2790                 2795                 2800 


Gln Leu Ile Pro Val  Ile Ser Asp Tyr Leu  Leu Ser Asn Leu Lys  
                2805                 2810                 2815 


Gly Ile Ala His Cys  Val Asn Ile His Ser  Gln Gln His Val Leu  
                2820                 2825                 2830 


Val Met Cys Ala Thr  Ala Phe Tyr Leu Ile  Glu Asn Tyr Pro Leu  
                2835                 2840                 2845 


Asp Val Gly Pro Glu  Phe Ser Ala Ser Ile  Ile Gln Met Cys Gly  
                2850                 2855                 2860 


Val Met Leu Ser Gly  Ser Glu Glu Ser Thr  Pro Ser Ile Ile Tyr  
                2865                 2870                 2875 


His Cys Ala Leu Arg  Gly Leu Glu Arg Leu  Leu Leu Ser Glu Gln  
                2880                 2885                 2890 


Leu Ser Arg Leu Asp  Ala Glu Ser Leu Val  Lys Leu Ser Val Asp  
                2895                 2900                 2905 


Arg Val Asn Val His  Ser Pro His Arg Ala  Met Ala Ala Leu Gly  
                2910                 2915                 2920 


Leu Met Leu Thr Cys  Met Tyr Thr Gly Lys  Glu Lys Val Ser Pro  
                2925                 2930                 2935 


Gly Arg Thr Ser Asp  Pro Asn Pro Ala Ala  Pro Asp Ser Glu Ser  
                2940                 2945                 2950 


Val Ile Val Ala Met  Glu Arg Val Ser Val  Leu Phe Asp Arg Ile  
                2955                 2960                 2965 


Arg Lys Gly Phe Pro  Cys Glu Ala Arg Val  Val Ala Arg Ile Leu  
                2970                 2975                 2980 


Pro Gln Phe Leu Asp  Asp Phe Phe Pro Pro  Gln Asp Ile Met Asn  
                2985                 2990                 2995 


Lys Val Ile Gly Glu  Phe Leu Ser Asn Gln  Gln Pro Tyr Pro Gln  
                3000                 3005                 3010 


Phe Met Ala Thr Val  Val Tyr Lys Val Phe  Gln Thr Leu His Ser  
                3015                 3020                 3025 


Thr Gly Gln Ser Ser  Met Val Arg Asp Trp  Val Met Leu Ser Leu  
                3030                 3035                 3040 


Ser Asn Phe Thr Gln  Arg Ala Pro Val Ala  Met Ala Thr Trp Ser  
                3045                 3050                 3055 


Leu Ser Cys Phe Phe  Val Ser Ala Ser Thr  Ser Pro Trp Val Ala  
                3060                 3065                 3070 


Ala Ile Leu Pro His  Val Ile Ser Arg Met  Gly Lys Leu Glu Gln  
                3075                 3080                 3085 


Val Asp Val Asn Leu  Phe Cys Leu Val Ala  Thr Asp Phe Tyr Arg  
                3090                 3095                 3100 


His Gln Ile Glu Glu  Glu Leu Asp Arg Arg  Ala Phe Gln Ser Val  
                3105                 3110                 3115 


Leu Glu Val Val Ala  Ala Pro Gly Ser Pro  Tyr His Arg Leu Leu  
                3120                 3125                 3130 


Thr Cys Leu Arg Asn  Val His Lys Val Thr  Thr Cys 
                3135                 3140         


<210>  4
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4

Gly Thr Ile Ile Lys Glu Asn Ile Gly Val Ser Tyr Asp Glu Tyr Arg 
1               5                   10                  15      


Tyr Arg 
        


