                         SEQUENCE LISTING

<110>  PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120>  CAS9 PROTEINS INCLUDING LIGAND-DEPENDENT INTEINS

<130>  H0824.70183WO00

<140>  PCT/US2015/042770
<141>  2015-07-30

<150>  US 62/135,629
<151>  2015-03-19

<150>  US 62/030,943
<151>  2014-07-30

<160>  173   

<170>  PatentIn version 3.5

<210>  1
<211>  4104
<212>  DNA
<213>  Streptococcus pyogenes

<400>  1
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg attataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg gcagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggcag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa atctacaatc aattatttga agaaaaccct      600

attaacgcaa gtagagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga gaaatggctt gtttgggaat      720

ctcattgctt tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatagt gaaataacta aggctcccct atcagcttca      960

atgattaagc gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgagggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggcgcct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agataggggg atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga tattcaaaaa gcacaggtgt ctggacaagg ccatagttta     2160

catgaacaga ttgctaactt agctggcagt cctgctatta aaaaaggtat tttacagact     2220

gtaaaaattg ttgatgaact ggtcaaagta atggggcata agccagaaaa tatcgttatt     2280

gaaatggcac gtgaaaatca gacaactcaa aagggccaga aaaattcgcg agagcgtatg     2340

aaacgaatcg aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt     2400

gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctacaaaa tggaagagac     2460

atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt cgatcacatt     2520

gttccacaaa gtttcattaa agacgattca atagacaata aggtactaac gcgttctgat     2580

aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa gatgaaaaac     2640

tattggagac aacttctaaa cgccaagtta atcactcaac gtaagtttga taatttaacg     2700

aaagctgaac gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg     2760

gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact     2820

aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa     2880

ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac     2940

catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat taagaaatat     3000

ccaaaacttg aatcggagtt tgtctatggt gattataaag tttatgatgt tcgtaaaatg     3060

attgctaagt ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat     3120

atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct     3180

ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc     3240

acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag     3300

acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa gcttattgct     3360

cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg atagtccaac ggtagcttat     3420

tcagtcctag tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa     3480

gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt     3540

ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat     3600

agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa     3660

aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt agctagtcat     3720

tatgaaaagt tgaagggtag tccagaagat aacgaacaaa aacaattgtt tgtggagcag     3780

cataagcatt atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt     3840

ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca     3900

atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc     3960

gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa     4020

gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac acgcattgat     4080

ttgagtcagc taggaggtga ctga                                            4104


<210>  2
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  2

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  3
<211>  4104
<212>  DNA
<213>  Homo sapiens

<400>  3
atggataaaa agtattctat tggtttagac atcggcacta attccgttgg atgggctgtc       60

ataaccgatg aatacaaagt accttcaaag aaatttaagg tgttggggaa cacagaccgt      120

cattcgatta aaaagaatct tatcggtgcc ctcctattcg atagtggcga aacggcagag      180

gcgactcgcc tgaaacgaac cgctcggaga aggtatacac gtcgcaagaa ccgaatatgt      240

tacttacaag aaatttttag caatgagatg gccaaagttg acgattcttt ctttcaccgt      300

ttggaagagt ccttccttgt cgaagaggac aagaaacatg aacggcaccc catctttgga      360

aacatagtag atgaggtggc atatcatgaa aagtacccaa cgatttatca cctcagaaaa      420

aagctagttg actcaactga taaagcggac ctgaggttaa tctacttggc tcttgcccat      480

atgataaagt tccgtgggca ctttctcatt gagggtgatc taaatccgga caactcggat      540

gtcgacaaac tgttcatcca gttagtacaa acctataatc agttgtttga agagaaccct      600

ataaatgcaa gtggcgtgga tgcgaaggct attcttagcg cccgcctctc taaatcccga      660

cggctagaaa acctgatcgc acaattaccc ggagagaaga aaaatgggtt gttcggtaac      720

cttatagcgc tctcactagg cctgacacca aattttaagt cgaacttcga cttagctgaa      780

gatgccaaat tgcagcttag taaggacacg tacgatgacg atctcgacaa tctactggca      840

caaattggag atcagtatgc ggacttattt ttggctgcca aaaaccttag cgatgcaatc      900

ctcctatctg acatactgag agttaatact gagattacca aggcgccgtt atccgcttca      960

atgatcaaaa ggtacgatga acatcaccaa gacttgacac ttctcaaggc cctagtccgt     1020

cagcaactgc ctgagaaata taaggaaata ttctttgatc agtcgaaaaa cgggtacgca     1080

ggttatattg acggcggagc gagtcaagag gaattctaca agtttatcaa acccatatta     1140

gagaagatgg atgggacgga agagttgctt gtaaaactca atcgcgaaga tctactgcga     1200

aagcagcgga ctttcgacaa cggtagcatt ccacatcaaa tccacttagg cgaattgcat     1260

gctatactta gaaggcagga ggatttttat ccgttcctca aagacaatcg tgaaaagatt     1320

gagaaaatcc taacctttcg cataccttac tatgtgggac ccctggcccg agggaactct     1380

cggttcgcat ggatgacaag aaagtccgaa gaaacgatta ctccatggaa ttttgaggaa     1440

gttgtcgata aaggtgcgtc agctcaatcg ttcatcgaga ggatgaccaa ctttgacaag     1500

aatttaccga acgaaaaagt attgcctaag cacagtttac tttacgagta tttcacagtg     1560

tacaatgaac tcacgaaagt taagtatgtc actgagggca tgcgtaaacc cgcctttcta     1620

agcggagaac agaagaaagc aatagtagat ctgttattca agaccaaccg caaagtgaca     1680

gttaagcaat tgaaagagga ctactttaag aaaattgaat gcttcgattc tgtcgagatc     1740

tccggggtag aagatcgatt taatgcgtca cttggtacgt atcatgacct cctaaagata     1800

attaaagata aggacttcct ggataacgaa gagaatgaag atatcttaga agatatagtg     1860

ttgactctta ccctctttga agatcgggaa atgattgagg aaagactaaa aacatacgct     1920

cacctgttcg acgataaggt tatgaaacag ttaaagaggc gtcgctatac gggctgggga     1980

cgattgtcgc ggaaacttat caacgggata agagacaagc aaagtggtaa aactattctc     2040

gattttctaa agagcgacgg cttcgccaat aggaacttta tgcagctgat ccatgatgac     2100

tctttaacct tcaaagagga tatacaaaag gcacaggttt ccggacaagg ggactcattg     2160

cacgaacata ttgcgaatct tgctggttcg ccagccatca aaaagggcat actccagaca     2220

gtcaaagtag tggatgagct agttaaggtc atgggacgtc acaaaccgga aaacattgta     2280

atcgagatgg cacgcgaaaa tcaaacgact cagaaggggc aaaaaaacag tcgagagcgg     2340

atgaagagaa tagaagaggg tattaaagaa ctgggcagcc agatcttaaa ggagcatcct     2400

gtggaaaata cccaattgca gaacgagaaa ctttacctct attacctaca aaatggaagg     2460

gacatgtatg ttgatcagga actggacata aaccgtttat ctgattacga cgtcgatcac     2520

attgtacccc aatccttttt gaaggacgat tcaatcgaca ataaagtgct tacacgctcg     2580

gataagaacc gagggaaaag tgacaatgtt ccaagcgagg aagtcgtaaa gaaaatgaag     2640

aactattggc ggcagctcct aaatgcgaaa ctgataacgc aaagaaagtt cgataactta     2700

actaaagctg agaggggtgg cttgtctgaa cttgacaagg ccggatttat taaacgtcag     2760

ctcgtggaaa cccgccaaat cacaaagcat gttgcacaga tactagattc ccgaatgaat     2820

acgaaatacg acgagaacga taagctgatt cgggaagtca aagtaatcac tttaaagtca     2880

aaattggtgt cggacttcag aaaggatttt caattctata aagttaggga gataaataac     2940

taccaccatg cgcacgacgc ttatcttaat gccgtcgtag ggaccgcact cattaagaaa     3000

tacccgaagc tagaaagtga gtttgtgtat ggtgattaca aagtttatga cgtccgtaag     3060

atgatcgcga aaagcgaaca ggagataggc aaggctacag ccaaatactt cttttattct     3120

aacattatga atttctttaa gacggaaatc actctggcaa acggagagat acgcaaacga     3180

cctttaattg aaaccaatgg ggagacaggt gaaatcgtat gggataaggg ccgggacttc     3240

gcgacggtga gaaaagtttt gtccatgccc caagtcaaca tagtaaagaa aactgaggtg     3300

cagaccggag ggttttcaaa ggaatcgatt cttccaaaaa ggaatagtga taagctcatc     3360

gctcgtaaaa aggactggga cccgaaaaag tacggtggct tcgatagccc tacagttgcc     3420

tattctgtcc tagtagtggc aaaagttgag aagggaaaat ccaagaaact gaagtcagtc     3480

aaagaattat tggggataac gattatggag cgctcgtctt ttgaaaagaa ccccatcgac     3540

ttccttgagg cgaaaggtta caaggaagta aaaaaggatc tcataattaa actaccaaag     3600

tatagtctgt ttgagttaga aaatggccga aaacggatgt tggctagcgc cggagagctt     3660

caaaagggga acgaactcgc actaccgtct aaatacgtga atttcctgta tttagcgtcc     3720

cattacgaga agttgaaagg ttcacctgaa gataacgaac agaagcaact ttttgttgag     3780

cagcacaaac attatctcga cgaaatcata gagcaaattt cggaattcag taagagagtc     3840

atcctagctg atgccaatct ggacaaagta ttaagcgcat acaacaagca cagggataaa     3900

cccatacgtg agcaggcgga aaatattatc catttgttta ctcttaccaa cctcggcgct     3960

ccagccgcat tcaagtattt tgacacaacg atagatcgca aacgatacac ttctaccaag     4020

gaggtgctag acgcgacact gattcaccaa tccatcacgg gattatatga aactcggata     4080

gatttgtcac agcttggggg tgac                                            4104


<210>  4
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  5
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  6
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
1               5                   10                  15      


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
            20                  25                  30          


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
        35                  40                  45              


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
    50                  55                  60                  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
65                  70                  75                  80  


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
                85                  90                  95      


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
            100                 105                 110         


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
        115                 120                 125             


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
    130                 135                 140                 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
145                 150                 155                 160 


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
                165                 170                 175     


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
            180                 185                 190         


Asn Gly Glu Ile Asn Phe 
        195             


<210>  7
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  8
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Val Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Thr Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  9
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Pro Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  10
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  11
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Pro Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  12
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asn Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  13
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  14
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr 
1               5                   10                  15      


His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val 
            20                  25                  30          


Ala Val Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp 
        35                  40                  45              


Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Thr Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly 
65                  70                  75                  80  


Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro 
                85                  90                  95      


Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
            100                 105                 110         


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
        115                 120                 125             


Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
    130                 135                 140                 


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
145                 150                 155                 160 


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu 
                165                 170                 175     


Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
            180                 185                 190         


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
        195                 200                 205             


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
    210                 215                 220                 


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
225                 230                 235                 240 


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
                245                 250                 255     


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
            260                 265                 270         


His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
        275                 280                 285             


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
    290                 295                 300                 


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
305                 310                 315                 320 


His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu 
                325                 330                 335     


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly 
            340                 345                 350         


Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu 
        355                 360                 365             


His Asp Met Leu Ala Glu Glu Leu Arg Tyr Ser Val Ile Arg Glu Val 
    370                 375                 380                 


Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu 
385                 390                 395                 400 


His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys 
                405                 410             


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
1               5                   10          


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser 
            20      


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Val Pro Phe Leu Leu Glu Pro Asp Asn Ile Asn Gly Lys Thr Cys 
1               5                   10                  15  


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala 
1               5                   10          


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Lys Ile Ile Glu Gln Leu Pro Ser Ala 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Val Arg His Lys Leu Lys Arg Val Gly Ser 
1               5                   10  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser 
1               5                   10          


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Ser Arg Pro Asp Pro Ala 
1               5           


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Gly Gly Ser Met 
1               


<210>  27
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His 
                85                  90                  95      


Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala 
            100                 105                 110         


Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe 
        115                 120                 125             


Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala 
    130                 135                 140                 


Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp 
145                 150                 155                 160 


Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly 
                165                 170                 175     


Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val 
            180                 185                 190         


Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp 
        195                 200                 205             


Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn 
    210                 215                 220                 


Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val 
225                 230                 235                 240 


Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu 
                245                 250                 255     


Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met 
            260                 265                 270         


Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg 
        275                 280                 285             


Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu 
    290                 295                 300                 


Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu 
305                 310                 315                 320 


Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr 
                325                 330                 335     


Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His 
            340                 345                 350         


Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys 
        355                 360                 365             


Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu 
    370                 375                 380                 


Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His 
385                 390                 395                 400 


Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu 
                405                 410                 415     


Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala 
            420                 425                 430         


Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His 
        435                 440                 445             


Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu 
    450                 455                 460                 


Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His 
465                 470                 475                 480 


Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys Tyr Leu Gln Glu 
                485                 490                 495     


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            500                 505                 510         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        515                 520                 525             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    530                 535                 540                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
545                 550                 555                 560 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                565                 570                 575     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            580                 585                 590         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        595                 600                 605             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    610                 615                 620                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  28
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Cys Leu 
        115                 120                 125             


Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg 
    130                 135                 140                 


Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala 
145                 150                 155                 160 


Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp 
                165                 170                 175     


Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile 
            180                 185                 190         


Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg 
        195                 200                 205             


Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly 
    210                 215                 220                 


Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
225                 230                 235                 240 


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
                245                 250                 255     


Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
            260                 265                 270         


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
        275                 280                 285             


Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg 
    290                 295                 300                 


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
305                 310                 315                 320 


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
                325                 330                 335     


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
            340                 345                 350         


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
        355                 360                 365             


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
    370                 375                 380                 


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
385                 390                 395                 400 


Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
                405                 410                 415     


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
            420                 425                 430         


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
        435                 440                 445             


Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu 
    450                 455                 460                 


Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser 
465                 470                 475                 480 


Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp 
                485                 490                 495     


Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro 
            500                 505                 510         


Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr 
        515                 520                 525             


Leu Val Ala Glu Gly Val Val Val His Asn Cys Tyr His Glu Lys Tyr 
    530                 535                 540                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
545                 550                 555                 560 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                565                 570                 575     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            580                 585                 590         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        595                 600                 605             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    610                 615                 620                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  29
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr 
145                 150                 155                 160 


Thr His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val 
                165                 170                 175     


Val Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser 
            180                 185                 190         


Trp Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly 
        195                 200                 205             


Gly Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr 
    210                 215                 220                 


Gly Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly 
225                 230                 235                 240 


Pro Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
                245                 250                 255     


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
            260                 265                 270         


Tyr Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
        275                 280                 285             


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
    290                 295                 300                 


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu 
305                 310                 315                 320 


Leu Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
                325                 330                 335     


Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
            340                 345                 350         


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
        355                 360                 365             


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
    370                 375                 380                 


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
385                 390                 395                 400 


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
                405                 410                 415     


Ile His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
            420                 425                 430         


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
        435                 440                 445             


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
    450                 455                 460                 


Glu His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp 
465                 470                 475                 480 


Leu Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser 
                485                 490                 495     


Gly Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe 
            500                 505                 510         


Leu His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu 
        515                 520                 525             


Val Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu 
    530                 535                 540                 


Leu His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys Asp Lys 
545                 550                 555                 560 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                565                 570                 575     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            580                 585                 590         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        595                 600                 605             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    610                 615                 620                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  30
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Cys Leu Ala Glu Gly Thr 
    210                 215                 220                 


Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val 
225                 230                 235                 240 


Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly 
                245                 250                 255     


Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg 
            260                 265                 270         


Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr 
        275                 280                 285             


Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu 
    290                 295                 300                 


Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser 
305                 310                 315                 320 


Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp 
                325                 330                 335     


Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe 
            340                 345                 350         


Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu 
        355                 360                 365             


Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp 
    370                 375                 380                 


Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu 
385                 390                 395                 400 


Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys 
                405                 410                 415     


Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys 
            420                 425                 430         


Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser 
        435                 440                 445             


Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys 
    450                 455                 460                 


Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr 
465                 470                 475                 480 


Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu Asp Lys 
                485                 490                 495     


Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu 
            500                 505                 510         


Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His 
        515                 520                 525             


Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys 
    530                 535                 540                 


Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp 
545                 550                 555                 560 


Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg Val Gln Ala 
                565                 570                 575     


Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met Leu Ala Glu 
            580                 585                 590         


Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr Arg Arg Ala 
        595                 600                 605             


Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu Val Ala Glu 
    610                 615                 620                 


Gly Val Val Val His Asn Cys Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  31
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Cys Leu Ala Glu 
                325                 330                 335     


Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu 
            340                 345                 350         


Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys 
        355                 360                 365             


Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly 
    370                 375                 380                 


Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp 
385                 390                 395                 400 


Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala 
                405                 410                 415     


Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly 
            420                 425                 430         


Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu 
        435                 440                 445             


Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser 
    450                 455                 460                 


Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp 
465                 470                 475                 480 


Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe 
                485                 490                 495     


Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp 
            500                 505                 510         


Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro 
        515                 520                 525             


Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly 
    530                 535                 540                 


Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr 
545                 550                 555                 560 


Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys 
                565                 570                 575     


Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser 
            580                 585                 590         


Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu 
        595                 600                 605             


Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu 
    610                 615                 620                 


Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu 
625                 630                 635                 640 


Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser 
                645                 650                 655     


Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met 
            660                 665                 670         


Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg Val 
        675                 680                 685             


Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met Leu 
    690                 695                 700                 


Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr Arg 
705                 710                 715                 720 


Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu Val 
                725                 730                 735     


Ala Glu Gly Val Val Val His Asn Cys Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  32
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp 
        515                 520                 525             


Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val Val Asp Gly Arg 
    530                 535                 540                 


Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala 
545                 550                 555                 560 


Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg Asp Val Ile Gly 
                565                 570                 575     


Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr Pro Asp His Lys 
            580                 585                 590         


Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly 
        595                 600                 605             


Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser 
    610                 615                 620                 


Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
625                 630                 635                 640 


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser 
                645                 650                 655     


Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
            660                 665                 670         


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
        675                 680                 685             


Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu Ile Leu Met Ile 
    690                 695                 700                 


Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala 
705                 710                 715                 720 


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
                725                 730                 735     


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
            740                 745                 750         


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
        755                 760                 765             


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
    770                 775                 780                 


Glu Glu Lys Asp His Ile His Arg Ala Leu Asp Lys Ile Thr Asp Thr 
785                 790                 795                 800 


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
                805                 810                 815     


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
            820                 825                 830         


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Tyr Lys Asn Val 
        835                 840                 845             


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His Arg Leu 
    850                 855                 860                 


His Ala Gly Gly Ser Gly Ala Ser Arg Val Gln Ala Phe Ala Asp Ala 
865                 870                 875                 880 


Leu Asp Asp Lys Phe Leu His Asp Met Leu Ala Glu Gly Leu Arg Tyr 
                885                 890                 895     


Ser Val Ile Arg Glu Val Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp 
            900                 905                 910         


Leu Glu Val Glu Glu Leu His Thr Leu Val Ala Glu Gly Val Val Val 
        915                 920                 925             


His Asn Cys Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  33
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Leu Ala 
                565                 570                 575     


Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile 
            580                 585                 590         


Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala 
        595                 600                 605             


Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln 
    610                 615                 620                 


Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val 
625                 630                 635                 640 


Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala 
                645                 650                 655     


Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser 
            660                 665                 670         


Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala 
        675                 680                 685             


Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr 
    690                 695                 700                 


Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala 
705                 710                 715                 720 


Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly 
                725                 730                 735     


Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala 
            740                 745                 750         


Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His 
        755                 760                 765             


Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln 
    770                 775                 780                 


Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala 
785                 790                 795                 800 


Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val 
                805                 810                 815     


Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu 
            820                 825                 830         


Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala 
        835                 840                 845             


Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly 
    850                 855                 860                 


Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile 
865                 870                 875                 880 


Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr 
                885                 890                 895     


Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu 
            900                 905                 910         


Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg 
        915                 920                 925             


Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met 
    930                 935                 940                 


Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr 
945                 950                 955                 960 


Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu 
                965                 970                 975     


Val Ala Glu Gly Val Val Val His Asn Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  34
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Cys Leu Ala 
    610                 615                 620                 


Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile 
625                 630                 635                 640 


Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala 
                645                 650                 655     


Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln 
            660                 665                 670         


Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val 
        675                 680                 685             


Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala 
    690                 695                 700                 


Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser 
705                 710                 715                 720 


Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala 
                725                 730                 735     


Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr 
            740                 745                 750         


Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala 
        755                 760                 765             


Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly 
    770                 775                 780                 


Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala 
785                 790                 795                 800 


Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His 
                805                 810                 815     


Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln 
            820                 825                 830         


Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala 
        835                 840                 845             


Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val 
    850                 855                 860                 


Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu 
865                 870                 875                 880 


Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala 
                885                 890                 895     


Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly 
            900                 905                 910         


Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile 
        915                 920                 925             


Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr 
    930                 935                 940                 


Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu 
945                 950                 955                 960 


Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg 
                965                 970                 975     


Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met 
            980                 985                 990         


Leu Ala Glu Gly Leu Arg Tyr Ser  Val Ile Arg Glu Val  Leu Pro Thr 
        995                 1000                 1005             


Arg Arg  Ala Arg Thr Phe Asp  Leu Glu Val Glu Glu  Leu His Thr 
    1010                 1015                 1020             


Leu Val  Ala Glu Gly Val Val  Val His Asn Cys Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  35
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Cys Leu Ala Glu 
    690                 695                 700                 


Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu 
705                 710                 715                 720 


Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys 
                725                 730                 735     


Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly 
            740                 745                 750         


Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp 
        755                 760                 765             


Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala 
    770                 775                 780                 


Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly 
785                 790                 795                 800 


Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu 
                805                 810                 815     


Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser 
            820                 825                 830         


Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp 
        835                 840                 845             


Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe 
    850                 855                 860                 


Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp 
865                 870                 875                 880 


Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro 
                885                 890                 895     


Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly 
            900                 905                 910         


Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr 
        915                 920                 925             


Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys 
    930                 935                 940                 


Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser 
945                 950                 955                 960 


Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu 
                965                 970                 975     


Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu 
            980                 985                 990         


Thr Leu Gln Gln Gln His Gln Arg  Leu Ala Gln Leu Leu  Leu Ile Leu 
        995                 1000                 1005             


Ser His  Ile Arg His Met Ser  Asn Lys Gly Met Glu  His Leu Tyr 
    1010                 1015                 1020             


Ser Met  Lys Tyr Lys Asn Val  Val Pro Leu Tyr Asp  Leu Leu Leu 
    1025                 1030                 1035             


Glu Met  Leu Asp Ala His Arg  Leu His Ala Gly Gly  Ser Gly Ala 
    1040                 1045                 1050             


Ser Arg  Val Gln Ala Phe Ala  Asp Ala Leu Asp Asp  Lys Phe Leu 
    1055                 1060                 1065             


His Asp  Met Leu Ala Glu Gly  Leu Arg Tyr Ser Val  Ile Arg Glu 
    1070                 1075                 1080             


Val Leu  Pro Thr Arg Arg Ala  Arg Thr Phe Asp Leu  Glu Val Glu 
    1085                 1090                 1095             


Glu Leu  His Thr Leu Val Ala  Glu Gly Val Val Val  His Asn Cys 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  36
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Cys Leu Ala Glu Gly Thr Arg Ile Phe 
                725                 730                 735     


Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val Val Asp Gly 
            740                 745                 750         


Arg Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly Thr Leu Leu 
        755                 760                 765             


Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg Asp Val Ile 
    770                 775                 780                 


Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr Pro Asp His 
785                 790                 795                 800 


Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu Leu Arg Lys 
                805                 810                 815     


Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser Leu Ala Leu 
            820                 825                 830         


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
        835                 840                 845             


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe Ser Glu Ala 
    850                 855                 860                 


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
865                 870                 875                 880 


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
                885                 890                 895     


His Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu Ile Leu Met 
            900                 905                 910         


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe 
        915                 920                 925             


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
    930                 935                 940                 


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
945                 950                 955                 960 


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
                965                 970                 975     


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
            980                 985                 990         


Leu Glu Glu Lys Asp His Ile His  Arg Ala Leu Asp Lys  Ile Thr Asp 
        995                 1000                 1005             


Thr Leu  Ile His Leu Met Ala  Lys Ala Gly Leu Thr  Leu Gln Gln 
    1010                 1015                 1020             


Gln His  Gln Arg Leu Ala Gln  Leu Leu Leu Ile Leu  Ser His Ile 
    1025                 1030                 1035             


Arg His  Met Ser Asn Lys Gly  Met Glu His Leu Tyr  Ser Met Lys 
    1040                 1045                 1050             


Tyr Lys  Asn Val Val Pro Leu  Tyr Asp Leu Leu Leu  Glu Met Leu 
    1055                 1060                 1065             


Asp Ala  His Arg Leu His Ala  Gly Gly Ser Gly Ala  Ser Arg Val 
    1070                 1075                 1080             


Gln Ala  Phe Ala Asp Ala Leu  Asp Asp Lys Phe Leu  His Asp Met 
    1085                 1090                 1095             


Leu Ala  Glu Gly Leu Arg Tyr  Ser Val Ile Arg Glu  Val Leu Pro 
    1100                 1105                 1110             


Thr Arg  Arg Ala Arg Thr Phe  Asp Leu Glu Val Glu  Glu Leu His 
    1115                 1120                 1125             


Thr Leu  Val Ala Glu Gly Val  Val Val His Asn Cys  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  37
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Cys Leu Ala Glu Gly Thr  Arg Ile Phe Asp Pro  Val Thr Gly 
        995                 1000                 1005             


Thr Thr  His Arg Ile Glu Asp  Val Val Asp Gly Arg  Lys Pro Ile 
    1010                 1015                 1020             


His Val  Val Ala Ala Ala Lys  Asp Gly Thr Leu Leu  Ala Arg Pro 
    1025                 1030                 1035             


Val Val  Ser Trp Phe Asp Gln  Gly Thr Arg Asp Val  Ile Gly Leu 
    1040                 1045                 1050             


Arg Ile  Ala Gly Gly Ala Ile  Val Trp Ala Thr Pro  Asp His Lys 
    1055                 1060                 1065             


Val Leu  Thr Glu Tyr Gly Trp  Arg Ala Ala Gly Glu  Leu Arg Lys 
    1070                 1075                 1080             


Gly Asp  Arg Val Ala Gly Pro  Gly Gly Ser Gly Asn  Ser Leu Ala 
    1085                 1090                 1095             


Leu Ser  Leu Thr Ala Asp Gln  Met Val Ser Ala Leu  Leu Asp Ala 
    1100                 1105                 1110             


Glu Pro  Pro Ile Leu Tyr Ser  Glu Tyr Asp Pro Thr  Ser Pro Phe 
    1115                 1120                 1125             


Ser Glu  Ala Ser Met Met Gly  Leu Leu Thr Asn Leu  Ala Asp Arg 
    1130                 1135                 1140             


Glu Leu  Val His Met Ile Asn  Trp Ala Lys Arg Val  Pro Gly Phe 
    1145                 1150                 1155             


Val Asp  Leu Thr Leu His Asp  Gln Ala His Leu Leu  Glu Arg Ala 
    1160                 1165                 1170             


Trp Leu  Glu Ile Leu Met Ile  Gly Leu Val Trp Arg  Ser Met Glu 
    1175                 1180                 1185             


His Pro  Gly Lys Leu Leu Phe  Ala Pro Asn Leu Leu  Leu Asp Arg 
    1190                 1195                 1200             


Asn Gln  Gly Lys Cys Val Glu  Gly Met Val Glu Ile  Phe Asp Met 
    1205                 1210                 1215             


Leu Leu  Ala Thr Ser Ser Arg  Phe Arg Met Met Asn  Leu Gln Gly 
    1220                 1225                 1230             


Glu Glu  Phe Val Cys Leu Lys  Ser Ile Ile Leu Leu  Asn Ser Gly 
    1235                 1240                 1245             


Val Tyr  Thr Phe Leu Ser Ser  Thr Leu Lys Ser Leu  Glu Glu Lys 
    1250                 1255                 1260             


Asp His  Ile His Arg Ala Leu  Asp Lys Ile Thr Asp  Thr Leu Ile 
    1265                 1270                 1275             


His Leu  Met Ala Lys Ala Gly  Leu Thr Leu Gln Gln  Gln His Gln 
    1280                 1285                 1290             


Arg Leu  Ala Gln Leu Leu Leu  Ile Leu Ser His Ile  Arg His Met 
    1295                 1300                 1305             


Ser Asn  Lys Gly Met Glu His  Leu Tyr Ser Met Lys  Tyr Lys Asn 
    1310                 1315                 1320             


Val Val  Pro Leu Tyr Asp Leu  Leu Leu Glu Met Leu  Asp Ala His 
    1325                 1330                 1335             


Arg Leu  His Ala Gly Gly Ser  Gly Ala Ser Arg Val  Gln Ala Phe 
    1340                 1345                 1350             


Ala Asp  Ala Leu Asp Asp Lys  Phe Leu His Asp Met  Leu Ala Glu 
    1355                 1360                 1365             


Gly Leu  Arg Tyr Ser Val Ile  Arg Glu Val Leu Pro  Thr Arg Arg 
    1370                 1375                 1380             


Ala Arg  Thr Phe Asp Leu Glu  Val Glu Glu Leu His  Thr Leu Val 
    1385                 1390                 1395             


Ala Glu  Gly Val Val Val His  Asn Cys Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  38
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Cys Leu Ala 
        995                 1000                 1005             


Glu Gly  Thr Arg Ile Phe Asp  Pro Val Thr Gly Thr  Thr His Arg 
    1010                 1015                 1020             


Ile Glu  Asp Val Val Asp Gly  Arg Lys Pro Ile His  Val Val Ala 
    1025                 1030                 1035             


Ala Ala  Lys Asp Gly Thr Leu  Leu Ala Arg Pro Val  Val Ser Trp 
    1040                 1045                 1050             


Phe Asp  Gln Gly Thr Arg Asp  Val Ile Gly Leu Arg  Ile Ala Gly 
    1055                 1060                 1065             


Gly Ala  Ile Val Trp Ala Thr  Pro Asp His Lys Val  Leu Thr Glu 
    1070                 1075                 1080             


Tyr Gly  Trp Arg Ala Ala Gly  Glu Leu Arg Lys Gly  Asp Arg Val 
    1085                 1090                 1095             


Ala Gly  Pro Gly Gly Ser Gly  Asn Ser Leu Ala Leu  Ser Leu Thr 
    1100                 1105                 1110             


Ala Asp  Gln Met Val Ser Ala  Leu Leu Asp Ala Glu  Pro Pro Ile 
    1115                 1120                 1125             


Leu Tyr  Ser Glu Tyr Asp Pro  Thr Ser Pro Phe Ser  Glu Ala Ser 
    1130                 1135                 1140             


Met Met  Gly Leu Leu Thr Asn  Leu Ala Asp Arg Glu  Leu Val His 
    1145                 1150                 1155             


Met Ile  Asn Trp Ala Lys Arg  Val Pro Gly Phe Val  Asp Leu Thr 
    1160                 1165                 1170             


Leu His  Asp Gln Ala His Leu  Leu Glu Arg Ala Trp  Leu Glu Ile 
    1175                 1180                 1185             


Leu Met  Ile Gly Leu Val Trp  Arg Ser Met Glu His  Pro Gly Lys 
    1190                 1195                 1200             


Leu Leu  Phe Ala Pro Asn Leu  Leu Leu Asp Arg Asn  Gln Gly Lys 
    1205                 1210                 1215             


Cys Val  Glu Gly Met Val Glu  Ile Phe Asp Met Leu  Leu Ala Thr 
    1220                 1225                 1230             


Ser Ser  Arg Phe Arg Met Met  Asn Leu Gln Gly Glu  Glu Phe Val 
    1235                 1240                 1245             


Cys Leu  Lys Ser Ile Ile Leu  Leu Asn Ser Gly Val  Tyr Thr Phe 
    1250                 1255                 1260             


Leu Ser  Ser Thr Leu Lys Ser  Leu Glu Glu Lys Asp  His Ile His 
    1265                 1270                 1275             


Arg Ala  Leu Asp Lys Ile Thr  Asp Thr Leu Ile His  Leu Met Ala 
    1280                 1285                 1290             


Lys Ala  Gly Leu Thr Leu Gln  Gln Gln His Gln Arg  Leu Ala Gln 
    1295                 1300                 1305             


Leu Leu  Leu Ile Leu Ser His  Ile Arg His Met Ser  Asn Lys Gly 
    1310                 1315                 1320             


Met Glu  His Leu Tyr Ser Met  Lys Tyr Lys Asn Val  Val Pro Leu 
    1325                 1330                 1335             


Tyr Asp  Leu Leu Leu Glu Met  Leu Asp Ala His Arg  Leu His Ala 
    1340                 1345                 1350             


Gly Gly  Ser Gly Ala Ser Arg  Val Gln Ala Phe Ala  Asp Ala Leu 
    1355                 1360                 1365             


Asp Asp  Lys Phe Leu His Asp  Met Leu Ala Glu Gly  Leu Arg Tyr 
    1370                 1375                 1380             


Ser Val  Ile Arg Glu Val Leu  Pro Thr Arg Arg Ala  Arg Thr Phe 
    1385                 1390                 1395             


Asp Leu  Glu Val Glu Glu Leu  His Thr Leu Val Ala  Glu Gly Val 
    1400                 1405                 1410             


Val Val  His Asn Cys Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  39
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Cys Leu  Ala Glu Gly 
    1145                 1150                 1155             


Thr Arg  Ile Phe Asp Pro Val  Thr Gly Thr Thr His  Arg Ile Glu 
    1160                 1165                 1170             


Asp Val  Val Asp Gly Arg Lys  Pro Ile His Val Val  Ala Ala Ala 
    1175                 1180                 1185             


Lys Asp  Gly Thr Leu Leu Ala  Arg Pro Val Val Ser  Trp Phe Asp 
    1190                 1195                 1200             


Gln Gly  Thr Arg Asp Val Ile  Gly Leu Arg Ile Ala  Gly Gly Ala 
    1205                 1210                 1215             


Ile Val  Trp Ala Thr Pro Asp  His Lys Val Leu Thr  Glu Tyr Gly 
    1220                 1225                 1230             


Trp Arg  Ala Ala Gly Glu Leu  Arg Lys Gly Asp Arg  Val Ala Gly 
    1235                 1240                 1245             


Pro Gly  Gly Ser Gly Asn Ser  Leu Ala Leu Ser Leu  Thr Ala Asp 
    1250                 1255                 1260             


Gln Met  Val Ser Ala Leu Leu  Asp Ala Glu Pro Pro  Ile Leu Tyr 
    1265                 1270                 1275             


Ser Glu  Tyr Asp Pro Thr Ser  Pro Phe Ser Glu Ala  Ser Met Met 
    1280                 1285                 1290             


Gly Leu  Leu Thr Asn Leu Ala  Asp Arg Glu Leu Val  His Met Ile 
    1295                 1300                 1305             


Asn Trp  Ala Lys Arg Val Pro  Gly Phe Val Asp Leu  Thr Leu His 
    1310                 1315                 1320             


Asp Gln  Ala His Leu Leu Glu  Arg Ala Trp Leu Glu  Ile Leu Met 
    1325                 1330                 1335             


Ile Gly  Leu Val Trp Arg Ser  Met Glu His Pro Gly  Lys Leu Leu 
    1340                 1345                 1350             


Phe Ala  Pro Asn Leu Leu Leu  Asp Arg Asn Gln Gly  Lys Cys Val 
    1355                 1360                 1365             


Glu Gly  Met Val Glu Ile Phe  Asp Met Leu Leu Ala  Thr Ser Ser 
    1370                 1375                 1380             


Arg Phe  Arg Met Met Asn Leu  Gln Gly Glu Glu Phe  Val Cys Leu 
    1385                 1390                 1395             


Lys Ser  Ile Ile Leu Leu Asn  Ser Gly Val Tyr Thr  Phe Leu Ser 
    1400                 1405                 1410             


Ser Thr  Leu Lys Ser Leu Glu  Glu Lys Asp His Ile  His Arg Ala 
    1415                 1420                 1425             


Leu Asp  Lys Ile Thr Asp Thr  Leu Ile His Leu Met  Ala Lys Ala 
    1430                 1435                 1440             


Gly Leu  Thr Leu Gln Gln Gln  His Gln Arg Leu Ala  Gln Leu Leu 
    1445                 1450                 1455             


Leu Ile  Leu Ser His Ile Arg  His Met Ser Asn Lys  Gly Met Glu 
    1460                 1465                 1470             


His Leu  Tyr Ser Met Lys Tyr  Lys Asn Val Val Pro  Leu Tyr Asp 
    1475                 1480                 1485             


Leu Leu  Leu Glu Met Leu Asp  Ala His Arg Leu His  Ala Gly Gly 
    1490                 1495                 1500             


Ser Gly  Ala Ser Arg Val Gln  Ala Phe Ala Asp Ala  Leu Asp Asp 
    1505                 1510                 1515             


Lys Phe  Leu His Asp Met Leu  Ala Glu Gly Leu Arg  Tyr Ser Val 
    1520                 1525                 1530             


Ile Arg  Glu Val Leu Pro Thr  Arg Arg Ala Arg Thr  Phe Asp Leu 
    1535                 1540                 1545             


Glu Val  Glu Glu Leu His Thr  Leu Val Ala Glu Gly  Val Val Val 
    1550                 1555                 1560             


His Asn  Cys Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  40
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Cys Leu  Ala Glu Gly Thr Arg  Ile Phe Asp Pro Val  Thr Gly Thr 
    1160                 1165                 1170             


Thr His  Arg Ile Glu Asp Val  Val Asp Gly Arg Lys  Pro Ile His 
    1175                 1180                 1185             


Val Val  Ala Ala Ala Lys Asp  Gly Thr Leu Leu Ala  Arg Pro Val 
    1190                 1195                 1200             


Val Ser  Trp Phe Asp Gln Gly  Thr Arg Asp Val Ile  Gly Leu Arg 
    1205                 1210                 1215             


Ile Ala  Gly Gly Ala Ile Val  Trp Ala Thr Pro Asp  His Lys Val 
    1220                 1225                 1230             


Leu Thr  Glu Tyr Gly Trp Arg  Ala Ala Gly Glu Leu  Arg Lys Gly 
    1235                 1240                 1245             


Asp Arg  Val Ala Gly Pro Gly  Gly Ser Gly Asn Ser  Leu Ala Leu 
    1250                 1255                 1260             


Ser Leu  Thr Ala Asp Gln Met  Val Ser Ala Leu Leu  Asp Ala Glu 
    1265                 1270                 1275             


Pro Pro  Ile Leu Tyr Ser Glu  Tyr Asp Pro Thr Ser  Pro Phe Ser 
    1280                 1285                 1290             


Glu Ala  Ser Met Met Gly Leu  Leu Thr Asn Leu Ala  Asp Arg Glu 
    1295                 1300                 1305             


Leu Val  His Met Ile Asn Trp  Ala Lys Arg Val Pro  Gly Phe Val 
    1310                 1315                 1320             


Asp Leu  Thr Leu His Asp Gln  Ala His Leu Leu Glu  Arg Ala Trp 
    1325                 1330                 1335             


Leu Glu  Ile Leu Met Ile Gly  Leu Val Trp Arg Ser  Met Glu His 
    1340                 1345                 1350             


Pro Gly  Lys Leu Leu Phe Ala  Pro Asn Leu Leu Leu  Asp Arg Asn 
    1355                 1360                 1365             


Gln Gly  Lys Cys Val Glu Gly  Met Val Glu Ile Phe  Asp Met Leu 
    1370                 1375                 1380             


Leu Ala  Thr Ser Ser Arg Phe  Arg Met Met Asn Leu  Gln Gly Glu 
    1385                 1390                 1395             


Glu Phe  Val Cys Leu Lys Ser  Ile Ile Leu Leu Asn  Ser Gly Val 
    1400                 1405                 1410             


Tyr Thr  Phe Leu Ser Ser Thr  Leu Lys Ser Leu Glu  Glu Lys Asp 
    1415                 1420                 1425             


His Ile  His Arg Ala Leu Asp  Lys Ile Thr Asp Thr  Leu Ile His 
    1430                 1435                 1440             


Leu Met  Ala Lys Ala Gly Leu  Thr Leu Gln Gln Gln  His Gln Arg 
    1445                 1450                 1455             


Leu Ala  Gln Leu Leu Leu Ile  Leu Ser His Ile Arg  His Met Ser 
    1460                 1465                 1470             


Asn Lys  Gly Met Glu His Leu  Tyr Ser Met Lys Tyr  Lys Asn Val 
    1475                 1480                 1485             


Val Pro  Leu Tyr Asp Leu Leu  Leu Glu Met Leu Asp  Ala His Arg 
    1490                 1495                 1500             


Leu His  Ala Gly Gly Ser Gly  Ala Ser Arg Val Gln  Ala Phe Ala 
    1505                 1510                 1515             


Asp Ala  Leu Asp Asp Lys Phe  Leu His Asp Met Leu  Ala Glu Gly 
    1520                 1525                 1530             


Leu Arg  Tyr Ser Val Ile Arg  Glu Val Leu Pro Thr  Arg Arg Ala 
    1535                 1540                 1545             


Arg Thr  Phe Asp Leu Glu Val  Glu Glu Leu His Thr  Leu Val Ala 
    1550                 1555                 1560             


Glu Gly  Val Val Val His Asn  Cys Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  41
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Cys Leu  Ala Glu Gly 
    1265                 1270                 1275             


Thr Arg  Ile Phe Asp Pro Val  Thr Gly Thr Thr His  Arg Ile Glu 
    1280                 1285                 1290             


Asp Val  Val Asp Gly Arg Lys  Pro Ile His Val Val  Ala Ala Ala 
    1295                 1300                 1305             


Lys Asp  Gly Thr Leu Leu Ala  Arg Pro Val Val Ser  Trp Phe Asp 
    1310                 1315                 1320             


Gln Gly  Thr Arg Asp Val Ile  Gly Leu Arg Ile Ala  Gly Gly Ala 
    1325                 1330                 1335             


Ile Val  Trp Ala Thr Pro Asp  His Lys Val Leu Thr  Glu Tyr Gly 
    1340                 1345                 1350             


Trp Arg  Ala Ala Gly Glu Leu  Arg Lys Gly Asp Arg  Val Ala Gly 
    1355                 1360                 1365             


Pro Gly  Gly Ser Gly Asn Ser  Leu Ala Leu Ser Leu  Thr Ala Asp 
    1370                 1375                 1380             


Gln Met  Val Ser Ala Leu Leu  Asp Ala Glu Pro Pro  Ile Leu Tyr 
    1385                 1390                 1395             


Ser Glu  Tyr Asp Pro Thr Ser  Pro Phe Ser Glu Ala  Ser Met Met 
    1400                 1405                 1410             


Gly Leu  Leu Thr Asn Leu Ala  Asp Arg Glu Leu Val  His Met Ile 
    1415                 1420                 1425             


Asn Trp  Ala Lys Arg Val Pro  Gly Phe Val Asp Leu  Thr Leu His 
    1430                 1435                 1440             


Asp Gln  Ala His Leu Leu Glu  Arg Ala Trp Leu Glu  Ile Leu Met 
    1445                 1450                 1455             


Ile Gly  Leu Val Trp Arg Ser  Met Glu His Pro Gly  Lys Leu Leu 
    1460                 1465                 1470             


Phe Ala  Pro Asn Leu Leu Leu  Asp Arg Asn Gln Gly  Lys Cys Val 
    1475                 1480                 1485             


Glu Gly  Met Val Glu Ile Phe  Asp Met Leu Leu Ala  Thr Ser Ser 
    1490                 1495                 1500             


Arg Phe  Arg Met Met Asn Leu  Gln Gly Glu Glu Phe  Val Cys Leu 
    1505                 1510                 1515             


Lys Ser  Ile Ile Leu Leu Asn  Ser Gly Val Tyr Thr  Phe Leu Ser 
    1520                 1525                 1530             


Ser Thr  Leu Lys Ser Leu Glu  Glu Lys Asp His Ile  His Arg Ala 
    1535                 1540                 1545             


Leu Asp  Lys Ile Thr Asp Thr  Leu Ile His Leu Met  Ala Lys Ala 
    1550                 1555                 1560             


Gly Leu  Thr Leu Gln Gln Gln  His Gln Arg Leu Ala  Gln Leu Leu 
    1565                 1570                 1575             


Leu Ile  Leu Ser His Ile Arg  His Met Ser Asn Lys  Gly Met Glu 
    1580                 1585                 1590             


His Leu  Tyr Ser Met Lys Tyr  Lys Asn Val Val Pro  Leu Tyr Asp 
    1595                 1600                 1605             


Leu Leu  Leu Glu Met Leu Asp  Ala His Arg Leu His  Ala Gly Gly 
    1610                 1615                 1620             


Ser Gly  Ala Ser Arg Val Gln  Ala Phe Ala Asp Ala  Leu Asp Asp 
    1625                 1630                 1635             


Lys Phe  Leu His Asp Met Leu  Ala Glu Gly Leu Arg  Tyr Ser Val 
    1640                 1645                 1650             


Ile Arg  Glu Val Leu Pro Thr  Arg Arg Ala Arg Thr  Phe Asp Leu 
    1655                 1660                 1665             


Glu Val  Glu Glu Leu His Thr  Leu Val Ala Glu Gly  Val Val Val 
    1670                 1675                 1680             


His Asn  Cys Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  
    1775                 1780 


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Arg Gly Val Pro 
1               5                   10                  15      


<210>  43
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys 
            20              


<210>  44
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  44
atggccctgt ttggctacgc acgcgtgtct accagtcaac agtcactcga tttgcaagtg       60

agggctctta aagatgccgg agtgaaggca aacagaattt ttactgataa ggccagcgga      120

agcagcacag acagagaggg gctggatctc ctgagaatga aggtaaagga gggtgatgtg      180

atcttggtca aaaaattgga tcgactgggg agagacacag ctgatatgct tcagcttatt      240

aaagagtttg acgctcaggg tgttgccgtg aggtttatcg atgacggcat ctcaaccgac      300

tcctacattg gtcttatgtt tgtgacaatt ttgtccgctg tggctcaggc tgagcggaga      360

aggattctcg aaaggacgaa tgagggacgg caagcagcta agttgaaagg tatcaaattt      420

ggcagacgaa gg                                                          432


<210>  45
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Met Ala Leu Phe Gly Tyr Ala Arg Val Ser Thr Ser Gln Gln Ser Leu 
1               5                   10                  15      


Asp Leu Gln Val Arg Ala Leu Lys Asp Ala Gly Val Lys Ala Asn Arg 
            20                  25                  30          


Ile Phe Thr Asp Lys Ala Ser Gly Ser Ser Thr Asp Arg Glu Gly Leu 
        35                  40                  45              


Asp Leu Leu Arg Met Lys Val Lys Glu Gly Asp Val Ile Leu Val Lys 
    50                  55                  60                  


Lys Leu Asp Arg Leu Gly Arg Asp Thr Ala Asp Met Leu Gln Leu Ile 
65                  70                  75                  80  


Lys Glu Phe Asp Ala Gln Gly Val Ala Val Arg Phe Ile Asp Asp Gly 
                85                  90                  95      


Ile Ser Thr Asp Ser Tyr Ile Gly Leu Met Phe Val Thr Ile Leu Ser 
            100                 105                 110         


Ala Val Ala Gln Ala Glu Arg Arg Arg Ile Leu Glu Arg Thr Asn Glu 
        115                 120                 125             


Gly Arg Gln Ala Ala Lys Leu Lys Gly Ile Lys Phe Gly Arg Arg Arg 
    130                 135                 140                 


<210>  46
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
atggcaacca ttggctacat aagggtgtct accatcgacc aaaatatcga cctgcagcgc       60

aacgctctga catccgccaa ctgcgatcgg atcttcgagg ataggatcag tggcaagatc      120

gccaaccggc ccggtctgaa gcgggctctg aagtacgtga ataagggcga tactctggtt      180

gtgtggaagt tggatcgctt gggtagatca gtgaagaatc tcgtagccct gataagcgag      240

ctgcacgaga ggggtgcaca tttccattct ctgaccgatt ccatcgatac gtctagcgcc      300

atgggccgat tcttctttta cgtcatgtcc gccctcgctg aaatggagcg cgaacttatt      360

gttgaacgga ctttggctgg actggcagcg gctagagcac agggccgact tgga            414


<210>  47
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Met Ala Thr Ile Gly Tyr Ile Arg Val Ser Thr Ile Asp Gln Asn Ile 
1               5                   10                  15      


Asp Leu Gln Arg Asn Ala Leu Thr Ser Ala Asn Cys Asp Arg Ile Phe 
            20                  25                  30          


Glu Asp Arg Ile Ser Gly Lys Ile Ala Asn Arg Pro Gly Leu Lys Arg 
        35                  40                  45              


Ala Leu Lys Tyr Val Asn Lys Gly Asp Thr Leu Val Val Trp Lys Leu 
    50                  55                  60                  


Asp Arg Leu Gly Arg Ser Val Lys Asn Leu Val Ala Leu Ile Ser Glu 
65                  70                  75                  80  


Leu His Glu Arg Gly Ala His Phe His Ser Leu Thr Asp Ser Ile Asp 
                85                  90                  95      


Thr Ser Ser Ala Met Gly Arg Phe Phe Phe Tyr Val Met Ser Ala Leu 
            100                 105                 110         


Ala Glu Met Glu Arg Glu Leu Ile Val Glu Arg Thr Leu Ala Gly Leu 
        115                 120                 125             


Ala Ala Ala Arg Ala Gln Gly Arg Leu Gly 
    130                 135             


<210>  48
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  48
atgctcattg gctatgtaag ggtcagcacc aatgaccaaa acacagactt gcaacgcaat       60

gctttggttt gcgccggatg tgaacagata tttgaagata aactgagcgg cactcggaca      120

gacagacctg ggcttaagag agcactgaaa agactgcaga agggggacac cctggtcgtc      180

tggaaactgg atcgcctcgg acgcagcatg aaacatctga ttagcctggt tggtgagctt      240

agggagagag gaatcaactt cagaagcctg accgactcca tcgacaccag tagccccatg      300

ggacgattct tcttctatgt gatgggagca cttgctgaga tggaaagaga gcttattatc      360

gaaagaacta tggctggtat cgctgctgcc cggaacaaag gcagacggtt cggcagaccg      420

ccgaagagcg gc                                                          432


<210>  49
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Met Leu Ile Gly Tyr Val Arg Val Ser Thr Asn Asp Gln Asn Thr Asp 
1               5                   10                  15      


Leu Gln Arg Asn Ala Leu Val Cys Ala Gly Cys Glu Gln Ile Phe Glu 
            20                  25                  30          


Asp Lys Leu Ser Gly Thr Arg Thr Asp Arg Pro Gly Leu Lys Arg Ala 
        35                  40                  45              


Leu Lys Arg Leu Gln Lys Gly Asp Thr Leu Val Val Trp Lys Leu Asp 
    50                  55                  60                  


Arg Leu Gly Arg Ser Met Lys His Leu Ile Ser Leu Val Gly Glu Leu 
65                  70                  75                  80  


Arg Glu Arg Gly Ile Asn Phe Arg Ser Leu Thr Asp Ser Ile Asp Thr 
                85                  90                  95      


Ser Ser Pro Met Gly Arg Phe Phe Phe Tyr Val Met Gly Ala Leu Ala 
            100                 105                 110         


Glu Met Glu Arg Glu Leu Ile Ile Glu Arg Thr Met Ala Gly Ile Ala 
        115                 120                 125             


Ala Ala Arg Asn Lys Gly Arg Arg Phe Gly Arg Pro Pro Lys Ser Gly 
    130                 135                 140                 


<210>  50
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  51
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  51

Met Asp Ser Leu Leu Met Lys Gln Lys Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Cys Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Glu 
                85                  90                  95      


Phe Leu Arg Trp Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Gly Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Thr Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Met Leu Gly Phe 
        195             


<210>  52
<211>  198
<212>  PRT
<213>  Canis lupus familiaris

<400>  52

Met Asp Ser Leu Leu Met Lys Gln Arg Lys Phe Leu Tyr His Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ser Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Ala Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn Arg Glu Lys Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  53
<211>  199
<212>  PRT
<213>  Bos taurus

<400>  53

Met Asp Ser Leu Leu Lys Lys Gln Arg Gln Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg His Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Pro Thr Ser Phe Ser Leu Asp Phe Gly His 
        35                  40                  45              


Leu Arg Asn Lys Ala Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Tyr Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Asp Lys Glu Arg Lys Ala Glu Pro Glu Gly Leu Arg 
        115                 120                 125             


Arg Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp 
    130                 135                 140                 


Tyr Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe 
145                 150                 155                 160 


Lys Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln 
                165                 170                 175     


Leu Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp 
            180                 185                 190         


Ala Phe Arg Thr Leu Gly Leu 
        195                 


<210>  54
<211>  429
<212>  PRT
<213>  Mus musculus

<400>  54

Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Gly Tyr Ala Lys Gly Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Ile 
            100                 105                 110         


Val Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Val Gln Asp Pro Glu Thr Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Arg Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Gly Arg Arg Met Asp Pro Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Arg Met Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Thr Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu Arg Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210>  55
<211>  429
<212>  PRT
<213>  Rattus rattus

<400>  55

Met Gly Pro Phe Cys Leu Gly Cys Ser His Arg Lys Cys Tyr Ser Pro 
1               5                   10                  15      


Ile Arg Asn Leu Ile Ser Gln Glu Thr Phe Lys Phe His Phe Lys Asn 
            20                  25                  30          


Leu Arg Tyr Ala Ile Asp Arg Lys Asp Thr Phe Leu Cys Tyr Glu Val 
        35                  40                  45              


Thr Arg Lys Asp Cys Asp Ser Pro Val Ser Leu His His Gly Val Phe 
    50                  55                  60                  


Lys Asn Lys Asp Asn Ile His Ala Glu Ile Cys Phe Leu Tyr Trp Phe 
65                  70                  75                  80  


His Asp Lys Val Leu Lys Val Leu Ser Pro Arg Glu Glu Phe Lys Ile 
                85                  90                  95      


Thr Trp Tyr Met Ser Trp Ser Pro Cys Phe Glu Cys Ala Glu Gln Val 
            100                 105                 110         


Leu Arg Phe Leu Ala Thr His His Asn Leu Ser Leu Asp Ile Phe Ser 
        115                 120                 125             


Ser Arg Leu Tyr Asn Ile Arg Asp Pro Glu Asn Gln Gln Asn Leu Cys 
    130                 135                 140                 


Arg Leu Val Gln Glu Gly Ala Gln Val Ala Ala Met Asp Leu Tyr Glu 
145                 150                 155                 160 


Phe Lys Lys Cys Trp Lys Lys Phe Val Asp Asn Gly Gly Arg Arg Phe 
                165                 170                 175     


Arg Pro Trp Lys Lys Leu Leu Thr Asn Phe Arg Tyr Gln Asp Ser Lys 
            180                 185                 190         


Leu Gln Glu Ile Leu Arg Pro Cys Tyr Ile Pro Val Pro Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Leu Ser Asn Ile Cys Leu Thr Lys Gly Leu Pro Glu Thr 
    210                 215                 220                 


Arg Phe Cys Val Glu Arg Arg Arg Val His Leu Leu Ser Glu Glu Glu 
225                 230                 235                 240 


Phe Tyr Ser Gln Phe Tyr Asn Gln Arg Val Lys His Leu Cys Tyr Tyr 
                245                 250                 255     


His Gly Val Lys Pro Tyr Leu Cys Tyr Gln Leu Glu Gln Phe Asn Gly 
            260                 265                 270         


Gln Ala Pro Leu Lys Gly Cys Leu Leu Ser Glu Lys Gly Lys Gln His 
        275                 280                 285             


Ala Glu Ile Leu Phe Leu Asp Lys Ile Arg Ser Met Glu Leu Ser Gln 
    290                 295                 300                 


Val Ile Ile Thr Cys Tyr Leu Thr Trp Ser Pro Cys Pro Asn Cys Ala 
305                 310                 315                 320 


Trp Gln Leu Ala Ala Phe Lys Arg Asp Arg Pro Asp Leu Ile Leu His 
                325                 330                 335     


Ile Tyr Thr Ser Arg Leu Tyr Phe His Trp Lys Arg Pro Phe Gln Lys 
            340                 345                 350         


Gly Leu Cys Ser Leu Trp Gln Ser Gly Ile Leu Val Asp Val Met Asp 
        355                 360                 365             


Leu Pro Gln Phe Thr Asp Cys Trp Thr Asn Phe Val Asn Pro Lys Arg 
    370                 375                 380                 


Pro Phe Trp Pro Trp Lys Gly Leu Glu Ile Ile Ser Arg Arg Thr Gln 
385                 390                 395                 400 


Arg Arg Leu His Arg Ile Lys Glu Ser Trp Gly Leu Gln Asp Leu Val 
                405                 410                 415     


Asn Asp Phe Gly Asn Leu Gln Leu Gly Pro Pro Met Ser 
            420                 425                 


<210>  56
<211>  370
<212>  PRT
<213>  Macaca mulatta

<400>  56

Met Val Glu Pro Met Asp Pro Arg Thr Phe Val Ser Asn Phe Asn Asn 
1               5                   10                  15      


Arg Pro Ile Leu Ser Gly Leu Asn Thr Val Trp Leu Cys Cys Glu Val 
            20                  25                  30          


Lys Thr Lys Asp Pro Ser Gly Pro Pro Leu Asp Ala Lys Ile Phe Gln 
        35                  40                  45              


Gly Lys Val Tyr Ser Lys Ala Lys Tyr His Pro Glu Met Arg Phe Leu 
    50                  55                  60                  


Arg Trp Phe His Lys Trp Arg Gln Leu His His Asp Gln Glu Tyr Lys 
65                  70                  75                  80  


Val Thr Trp Tyr Val Ser Trp Ser Pro Cys Thr Arg Cys Ala Asn Ser 
                85                  90                  95      


Val Ala Thr Phe Leu Ala Lys Asp Pro Lys Val Thr Leu Thr Ile Phe 
            100                 105                 110         


Val Ala Arg Leu Tyr Tyr Phe Trp Lys Pro Asp Tyr Gln Gln Ala Leu 
        115                 120                 125             


Arg Ile Leu Cys Gln Lys Arg Gly Gly Pro His Ala Thr Met Lys Ile 
    130                 135                 140                 


Met Asn Tyr Asn Glu Phe Gln Asp Cys Trp Asn Lys Phe Val Asp Gly 
145                 150                 155                 160 


Arg Gly Lys Pro Phe Lys Pro Arg Asn Asn Leu Pro Lys His Tyr Thr 
                165                 170                 175     


Leu Leu Gln Ala Thr Leu Gly Glu Leu Leu Arg His Leu Met Asp Pro 
            180                 185                 190         


Gly Thr Phe Thr Ser Asn Phe Asn Asn Lys Pro Trp Val Ser Gly Gln 
        195                 200                 205             


His Glu Thr Tyr Leu Cys Tyr Lys Val Glu Arg Leu His Asn Asp Thr 
    210                 215                 220                 


Trp Val Pro Leu Asn Gln His Arg Gly Phe Leu Arg Asn Gln Ala Pro 
225                 230                 235                 240 


Asn Ile His Gly Phe Pro Lys Gly Arg His Ala Glu Leu Cys Phe Leu 
                245                 250                 255     


Asp Leu Ile Pro Phe Trp Lys Leu Asp Gly Gln Gln Tyr Arg Val Thr 
            260                 265                 270         


Cys Phe Thr Ser Trp Ser Pro Cys Phe Ser Cys Ala Gln Glu Met Ala 
        275                 280                 285             


Lys Phe Ile Ser Asn Asn Glu His Val Ser Leu Cys Ile Phe Ala Ala 
    290                 295                 300                 


Arg Ile Tyr Asp Asp Gln Gly Arg Tyr Gln Glu Gly Leu Arg Ala Leu 
305                 310                 315                 320 


His Arg Asp Gly Ala Lys Ile Ala Met Met Asn Tyr Ser Glu Phe Glu 
                325                 330                 335     


Tyr Cys Trp Asp Thr Phe Val Asp Arg Gln Gly Arg Pro Phe Gln Pro 
            340                 345                 350         


Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg 
        355                 360                 365             


Ala Ile 
    370 


<210>  57
<211>  384
<212>  PRT
<213>  Pan troglodytes

<400>  57

Met Lys Pro His Phe Arg Asn Pro Val Glu Arg Met Tyr Gln Asp Thr 
1               5                   10                  15      


Phe Ser Asp Asn Phe Tyr Asn Arg Pro Ile Leu Ser His Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Lys Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Glu Leu Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Leu His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu His Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Asn Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Lys Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser 
        355                 360                 365             


Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380                 


<210>  58
<211>  377
<212>  PRT
<213>  Chlorocebus sabaeus

<400>  58

Met Asn Pro Gln Ile Arg Asn Met Val Glu Gln Met Glu Pro Asp Ile 
1               5                   10                  15      


Phe Val Tyr Tyr Phe Asn Asn Arg Pro Ile Leu Ser Gly Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Asp Pro Ser Gly Pro Pro 
        35                  40                  45              


Leu Asp Ala Asn Ile Phe Gln Gly Lys Leu Tyr Pro Glu Ala Lys Asp 
    50                  55                  60                  


His Pro Glu Met Lys Phe Leu His Trp Phe Arg Lys Trp Arg Gln Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Val Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Arg Cys Ala Asn Ser Val Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Lys 
        115                 120                 125             


Pro Asp Tyr Gln Gln Ala Leu Arg Ile Leu Cys Gln Glu Arg Gly Gly 
    130                 135                 140                 


Pro His Ala Thr Met Lys Ile Met Asn Tyr Asn Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Asn Glu Phe Val Asp Gly Gln Gly Lys Pro Phe Lys Pro Arg Lys 
                165                 170                 175     


Asn Leu Pro Lys His Tyr Thr Leu Leu His Ala Thr Leu Gly Glu Leu 
            180                 185                 190         


Leu Arg His Val Met Asp Pro Gly Thr Phe Thr Ser Asn Phe Asn Asn 
        195                 200                 205             


Lys Pro Trp Val Ser Gly Gln Arg Glu Thr Tyr Leu Cys Tyr Lys Val 
    210                 215                 220                 


Glu Arg Ser His Asn Asp Thr Trp Val Leu Leu Asn Gln His Arg Gly 
225                 230                 235                 240 


Phe Leu Arg Asn Gln Ala Pro Asp Arg His Gly Phe Pro Lys Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Leu Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Asp Gln Gln Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys Phe 
        275                 280                 285             


Ser Cys Ala Gln Lys Met Ala Lys Phe Ile Ser Asn Asn Lys His Val 
    290                 295                 300                 


Ser Leu Cys Ile Phe Ala Ala Arg Ile Tyr Asp Asp Gln Gly Arg Cys 
305                 310                 315                 320 


Gln Glu Gly Leu Arg Thr Leu His Arg Asp Gly Ala Lys Ile Ala Val 
                325                 330                 335     


Met Asn Tyr Ser Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Asp Arg 
            340                 345                 350         


Gln Gly Arg Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
        355                 360                 365             


Ala Leu Ser Gly Arg Leu Arg Ala Ile 
    370                 375         


<210>  59
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210>  60
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Gln Pro Glu His 
    50                  55                  60                  


His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu Pro 
65                  70                  75                  80  


Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro Cys 
                85                  90                  95      


Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ala Glu His Pro Asn 
            100                 105                 110         


Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu Arg 
        115                 120                 125             


Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg Val 
    130                 135                 140                 


Lys Ile Met Asp Asp Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe Val 
145                 150                 155                 160 


Tyr Ser Glu Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn 
                165                 170                 175     


Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met 
            180                 185                 190         


Glu Ala Met Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Arg 
        195                 200                 205             


Lys Ala Tyr Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val 
    210                 215                 220                 


Val Lys His His Ser Pro Val Ser Trp Lys Arg Gly Val Phe Arg Asn 
225                 230                 235                 240 


Gln Val Asp Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser 
                245                 250                 255     


Trp Phe Cys Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr 
            260                 265                 270         


Trp Tyr Thr Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala 
        275                 280                 285             


Glu Phe Leu Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala 
    290                 295                 300                 


Arg Leu Tyr Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Arg Ser 
305                 310                 315                 320 


Leu Ser Gln Glu Gly Ala Ser Val Glu Ile Met Gly Tyr Lys Asp Phe 
                325                 330                 335     


Lys Tyr Cys Trp Glu Asn Phe Val Tyr Asn Asp Asp Glu Pro Phe Lys 
            340                 345                 350         


Pro Trp Lys Gly Leu Lys Tyr Asn Phe Leu Phe Leu Asp Ser Lys Leu 
        355                 360                 365             


Gln Glu Ile Leu Glu 
    370             


<210>  61
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Thr Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu 
                245                 250                 255     


Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile 
            260                 265                 270         


Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly 
        275                 280                 285             


Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg 
    290                 295                 300                 


Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys 
305                 310                 315                 320 


Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met 
                325                 330                 335     


Thr Tyr Asp Glu Phe Glu Tyr Cys Trp Asp Thr Phe Val Tyr Arg Gln 
            340                 345                 350         


Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Glu Glu His Ser Gln Ala 
        355                 360                 365             


Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn 
    370                 375                 380         


<210>  62
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr 
        115                 120                 125             


Pro Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 
                165                 170                 175     


Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 
            180                 185                 190 


<210>  63
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  64
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 
        35                  40                  45              


Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Phe Pro Lys Phe Ala Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 
145                 150                 155                 160 


Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ile Pro Gly Val Arg Ala Gln Gly Arg Tyr Met 
            180                 185                 190         


Asp Ile Leu Cys Asp Ala Glu Val 
        195                 200 


<210>  65
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Pro Val Leu Pro Lys Arg Gln 
    50                  55                  60                  


Ser Asn His Arg Gln Glu Val Tyr Phe Arg Phe Glu Asn His Ala Glu 
65                  70                  75                  80  


Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Arg Leu Pro Ala Asn Arg 
                85                  90                  95      


Arg Phe Gln Ile Thr Trp Phe Val Ser Trp Asn Pro Cys Leu Pro Cys 
            100                 105                 110         


Val Val Lys Val Thr Lys Phe Leu Ala Glu His Pro Asn Val Thr Leu 
        115                 120                 125             


Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Arg Asp Arg Asp Trp Arg 
    130                 135                 140                 


Trp Val Leu Leu Arg Leu His Lys Ala Gly Ala Arg Val Lys Ile Met 
145                 150                 155                 160 


Asp Tyr Glu Asp Phe Ala Tyr Cys Trp Glu Asn Phe Val Cys Asn Glu 
                165                 170                 175     


Gly Gln Pro Phe Met Pro Trp Tyr Lys Phe Asp Asp Asn Tyr Ala Ser 
            180                 185                 190         


Leu His Arg Thr Leu Lys Glu Ile Leu Arg Asn Pro Met Glu Ala Met 
        195                 200                 205             


Tyr Pro His Ile Phe Tyr Phe His Phe Lys Asn Leu Leu Lys Ala Cys 
    210                 215                 220                 


Gly Arg Asn Glu Ser Trp Leu Cys Phe Thr Met Glu Val Thr Lys His 
225                 230                 235                 240 


His Ser Ala Val Phe Arg Lys Arg Gly Val Phe Arg Asn Gln Val Asp 
                245                 250                 255     


Pro Glu Thr His Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys 
            260                 265                 270         


Asp Asp Ile Leu Ser Pro Asn Thr Asn Tyr Glu Val Thr Trp Tyr Thr 
        275                 280                 285             


Ser Trp Ser Pro Cys Pro Glu Cys Ala Gly Glu Val Ala Glu Phe Leu 
    290                 295                 300                 


Ala Arg His Ser Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Cys 
305                 310                 315                 320 


Tyr Phe Trp Asp Thr Asp Tyr Gln Glu Gly Leu Cys Ser Leu Ser Gln 
                325                 330                 335     


Glu Gly Ala Ser Val Lys Ile Met Gly Tyr Lys Asp Phe Val Ser Cys 
            340                 345                 350         


Trp Lys Asn Phe Val Tyr Ser Asp Asp Glu Pro Phe Lys Pro Trp Lys 
        355                 360                 365             


Gly Leu Gln Thr Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ile 
    370                 375                 380                 


Leu Gln 
385     


<210>  66
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg 
225                 230                 235     


<210>  67
<211>  229
<212>  PRT
<213>  Mus musculus

<400>  67

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Val Trp Arg His Thr Ser Gln Asn Thr Ser Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Leu Glu Lys Phe Thr Thr Glu Arg Tyr Phe Arg Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg His Pro Tyr Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Thr Asp Gln Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Tyr Cys Tyr Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Ser Asn Glu Ala Tyr Trp Pro Arg Tyr Pro His Leu Trp Val Lys 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Thr Leu Gln Thr Cys His Tyr Gln Arg Ile Pro Pro His Leu Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  68
<211>  229
<212>  PRT
<213>  Rattus rattus

<400>  68

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  69
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Glu Ala Lys Ala Ala Pro Lys Pro Ala Ala Ser Gly Ala Cys Ser 
1               5                   10                  15      


Val Ser Ala Glu Glu Thr Glu Lys Trp Met Glu Glu Ala Met His Met 
            20                  25                  30          


Ala Lys Glu Ala Leu Glu Asn Thr Glu Val Pro Val Gly Cys Leu Met 
        35                  40                  45              


Val Tyr Asn Asn Glu Val Val Gly Lys Gly Arg Asn Glu Val Asn Gln 
    50                  55                  60                  


Thr Lys Asn Ala Thr Arg His Ala Glu Met Val Ala Ile Asp Gln Val 
65                  70                  75                  80  


Leu Asp Trp Cys Arg Gln Ser Gly Lys Ser Pro Ser Glu Val Phe Glu 
                85                  90                  95      


His Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys Ala Ala 
            100                 105                 110         


Ala Leu Arg Leu Met Lys Ile Pro Leu Val Val Tyr Gly Cys Gln Asn 
        115                 120                 125             


Glu Arg Phe Gly Gly Cys Gly Ser Val Leu Asn Ile Ala Ser Ala Asp 
    130                 135                 140                 


Leu Pro Asn Thr Gly Arg Pro Phe Gln Cys Ile Pro Gly Tyr Arg Ala 
145                 150                 155                 160 


Glu Glu Ala Val Glu Met Leu Lys Thr Phe Tyr Lys Gln Glu Asn Pro 
                165                 170                 175     


Asn Ala Pro Lys Ser Lys Val Arg Lys Lys Glu Cys Gln Lys Ser 
            180                 185                 190     


<210>  70
<211>  191
<212>  PRT
<213>  Mus musculus

<400>  70

Met Glu Glu Lys Val Glu Ser Thr Thr Thr Pro Asp Gly Pro Cys Val 
1               5                   10                  15      


Val Ser Val Gln Glu Thr Glu Lys Trp Met Glu Glu Ala Met Arg Met 
            20                  25                  30          


Ala Lys Glu Ala Leu Glu Asn Ile Glu Val Pro Val Gly Cys Leu Met 
        35                  40                  45              


Val Tyr Asn Asn Glu Val Val Gly Lys Gly Arg Asn Glu Val Asn Gln 
    50                  55                  60                  


Thr Lys Asn Ala Thr Arg His Ala Glu Met Val Ala Ile Asp Gln Val 
65                  70                  75                  80  


Leu Asp Trp Cys His Gln His Gly Gln Ser Pro Ser Thr Val Phe Glu 
                85                  90                  95      


His Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys Ala Ala 
            100                 105                 110         


Ala Leu Arg Leu Met Lys Ile Pro Leu Val Val Tyr Gly Cys Gln Asn 
        115                 120                 125             


Glu Arg Phe Gly Gly Cys Gly Ser Val Leu Asn Ile Ala Ser Ala Asp 
    130                 135                 140                 


Leu Pro Asn Thr Gly Arg Pro Phe Gln Cys Ile Pro Gly Tyr Arg Ala 
145                 150                 155                 160 


Glu Glu Ala Val Glu Leu Leu Lys Thr Phe Tyr Lys Gln Glu Asn Pro 
                165                 170                 175     


Asn Ala Pro Lys Ser Lys Val Arg Lys Lys Asp Cys Gln Lys Ser 
            180                 185                 190     


<210>  71
<211>  499
<212>  PRT
<213>  Mus musculus

<400>  71

Met Trp Thr Ala Asp Glu Ile Ala Gln Leu Cys Tyr Ala His Tyr Asn 
1               5                   10                  15      


Val Arg Leu Pro Lys Gln Gly Lys Pro Glu Pro Asn Arg Glu Trp Thr 
            20                  25                  30          


Leu Leu Ala Ala Val Val Lys Ile Gln Ala Ser Ala Asn Gln Ala Cys 
        35                  40                  45              


Asp Ile Pro Glu Lys Glu Val Gln Val Thr Lys Glu Val Val Ser Met 
    50                  55                  60                  


Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Glu Ser Gly 
65                  70                  75                  80  


Asp Ile Leu Asn Asp Ser His Ala Glu Ile Ile Ala Arg Arg Ser Phe 
                85                  90                  95      


Gln Arg Tyr Leu Leu His Gln Leu His Leu Ala Ala Val Leu Lys Glu 
            100                 105                 110         


Asp Ser Ile Phe Val Pro Gly Thr Gln Arg Gly Leu Trp Arg Leu Arg 
        115                 120                 125             


Pro Asp Leu Ser Phe Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp 
    130                 135                 140                 


Ala Ser Ile Ile Pro Met Leu Glu Phe Glu Glu Gln Pro Cys Cys Pro 
145                 150                 155                 160 


Val Ile Arg Ser Trp Ala Asn Asn Ser Pro Val Gln Glu Thr Glu Asn 
                165                 170                 175     


Leu Glu Asp Ser Lys Asp Lys Arg Asn Cys Glu Asp Pro Ala Ser Pro 
            180                 185                 190         


Val Ala Lys Lys Met Arg Leu Gly Thr Pro Ala Arg Ser Leu Ser Asn 
        195                 200                 205             


Cys Val Ala His His Gly Thr Gln Glu Ser Gly Pro Val Lys Pro Asp 
    210                 215                 220                 


Val Ser Ser Ser Asp Leu Thr Lys Glu Glu Pro Asp Ala Ala Asn Gly 
225                 230                 235                 240 


Ile Ala Ser Gly Ser Phe Arg Val Val Asp Val Tyr Arg Thr Gly Ala 
                245                 250                 255     


Lys Cys Val Pro Gly Glu Thr Gly Asp Leu Arg Glu Pro Gly Ala Ala 
            260                 265                 270         


Tyr His Gln Val Gly Leu Leu Arg Val Lys Pro Gly Arg Gly Asp Arg 
        275                 280                 285             


Thr Cys Ser Met Ser Cys Ser Asp Lys Met Ala Arg Trp Asn Val Leu 
    290                 295                 300                 


Gly Cys Gln Gly Ala Leu Leu Met His Phe Leu Glu Lys Pro Ile Tyr 
305                 310                 315                 320 


Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr Ser Gln Glu Ala Met 
                325                 330                 335     


Arg Arg Ala Leu Thr Gly Arg Cys Glu Glu Thr Leu Val Leu Pro Arg 
            340                 345                 350         


Gly Phe Gly Val Gln Glu Leu Glu Ile Gln Gln Ser Gly Leu Leu Phe 
        355                 360                 365             


Glu Gln Ser Arg Cys Ala Val His Arg Lys Arg Gly Asp Ser Pro Gly 
    370                 375                 380                 


Arg Leu Val Pro Cys Gly Ala Ala Ile Ser Trp Ser Ala Val Pro Gln 
385                 390                 395                 400 


Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro Gln Gly Thr Thr Lys 
                405                 410                 415     


Lys Glu Ile Gly Ser Pro Arg Ala Arg Ser Arg Ile Ser Lys Val Glu 
            420                 425                 430         


Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Ser Ile Ala Asp Asp Glu 
        435                 440                 445             


Gln Pro Asp Ser Ile Arg Val Thr Lys Lys Leu Asp Thr Tyr Gln Glu 
    450                 455                 460                 


Tyr Lys Asp Ala Ala Ser Ala Tyr Gln Glu Ala Trp Gly Ala Leu Arg 
465                 470                 475                 480 


Arg Ile Gln Pro Phe Ala Ser Trp Ile Arg Asn Pro Pro Asp Tyr His 
                485                 490                 495     


Gln Phe Lys 
            


<210>  72
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Trp Thr Ala Asp Glu Ile Ala Gln Leu Cys Tyr Glu His Tyr Gly 
1               5                   10                  15      


Ile Arg Leu Pro Lys Lys Gly Lys Pro Glu Pro Asn His Glu Trp Thr 
            20                  25                  30          


Leu Leu Ala Ala Val Val Lys Ile Gln Ser Pro Ala Asp Lys Ala Cys 
        35                  40                  45              


Asp Thr Pro Asp Lys Pro Val Gln Val Thr Lys Glu Val Val Ser Met 
    50                  55                  60                  


Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly 
65                  70                  75                  80  


Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe 
                85                  90                  95      


Gln Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu Lys Glu 
            100                 105                 110         


Asp Ser Ile Phe Val Pro Gly Thr Gln Lys Gly Val Trp Lys Leu Arg 
        115                 120                 125             


Arg Asp Leu Ile Phe Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp 
    130                 135                 140                 


Ala Ser Ile Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro 
145                 150                 155                 160 


Val Phe Arg Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn 
                165                 170                 175     


Leu Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro 
            180                 185                 190         


Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val 
        195                 200                 205             


Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys Ser Gly 
    210                 215                 220                 


Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr Val Glu Gly Leu 
225                 230                 235                 240 


Ala Thr Val Thr Arg Ile Ala Pro Gly Ser Ala Lys Val Ile Asp Val 
                245                 250                 255     


Tyr Arg Thr Gly Ala Lys Cys Val Pro Gly Glu Ala Gly Asp Ser Gly 
            260                 265                 270         


Lys Pro Gly Ala Ala Phe His Gln Val Gly Leu Leu Arg Val Lys Pro 
        275                 280                 285             


Gly Arg Gly Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala 
    290                 295                 300                 


Arg Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu 
305                 310                 315                 320 


Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr 
                325                 330                 335     


Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln Asn Val 
            340                 345                 350         


Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu Leu Lys Ile Leu Gln 
        355                 360                 365             


Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser Ala Val Gln Ala Lys Arg 
    370                 375                 380                 


Ala Asp Ser Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile Ser Trp 
385                 390                 395                 400 


Ser Ala Val Pro Glu Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro 
                405                 410                 415     


Gln Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln 
            420                 425                 430         


Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg 
        435                 440                 445             


Ile Ala Arg Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu Asp 
    450                 455                 460                 


Thr Tyr Gln Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln Glu Ala Trp 
465                 470                 475                 480 


Ser Thr Leu Arg Lys Gln Val Phe Gly Ser Trp Ile Arg Asn Pro Pro 
                485                 490                 495     


Asp Tyr His Gln Phe Lys 
            500         


<210>  73
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  73

Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
1               5                   10                  15      


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
            20                  25                  30          


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        35                  40                  45              


Asp Phe Asp Leu Asp Met Leu Ile Asn 
    50                  55          


<210>  74
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  74

Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly 
1               5                   10                  15      


Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu 
            20                  25                  30          


Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His 
        35                  40                  45              


Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu 
    50                  55                  60                  


Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Glu Phe 
65                  70                  75                  80  


Pro Gly Ile Arg Arg 
                85  


<210>  75
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  75

Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
1               5                   10                  15      


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            20                  25                  30          


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        35                  40                  45              


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    50                  55                  60                  


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
65                  70                  75                  80  


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                85                  90                  95      


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            100                 105                 110         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        115                 120                 125             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    130                 135                 140                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
145                 150                 155                 160 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                165                 170                 175     


Ser Gln Ile Ser Ser Ser Gly Gln 
            180                 


<210>  76
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asn Met Phe Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val Ala 
1               5                   10                  15      


Phe Thr Glu Glu Glu Leu Gly Leu Leu Gly Pro Ala Gln Arg Lys Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Val Glu Asn Phe Arg Asn Leu Leu Ser Val Gly 
        35                  40                  45              


His Pro Pro Phe Lys Gln Asp Val Ser Pro Ile Glu Arg Asn Glu Gln 
    50                  55                  60                  


Leu Trp Ile Met Thr Thr Ala Thr Arg Arg Gln Gly Asn Leu Asp Thr 
65                  70                  75                  80  


Leu Pro Val Lys Ala Leu Leu Leu Tyr Asp Leu Ala Gln Thr 
                85                  90                  


<210>  77
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  77

Glu Gln Val Ser Phe Lys Asp Val Cys Val Asp Phe Thr Gln Glu Glu 
1               5                   10                  15      


Trp Tyr Leu Leu Asp Pro Ala Gln Lys Ile Leu Tyr Arg Asp Val Ile 
            20                  25                  30          


Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr Cys Ile Thr Lys 
        35                  40                  45              


Pro Glu Val Ile Phe Lys Ile Glu Gln Gly Glu Glu Pro Trp Ile Leu 
    50                  55                  60                  


Glu Lys Gly Phe Pro Ser Gln Cys His Pro 
65                  70                  


<210>  78
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  78

Glu Ala Val Thr Phe Lys Asp Val Ala Val Val Phe Thr Glu Glu Glu 
1               5                   10                  15      


Leu Gly Leu Leu Asp Pro Ala Gln Arg Lys Leu Tyr Arg Asp Val Met 
            20                  25                  30          


Leu Glu Asn Phe Arg Asn Leu Leu Ser Val 
        35                  40          


<210>  79
<211>  69
<212>  PRT
<213>  Mus musculus

<400>  79

Met Asp Leu Val Thr Tyr Asp Asp Val His Val Asn Phe Thr Gln Asp 
1               5                   10                  15      


Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Ser Leu Tyr Lys Gly Val 
            20                  25                  30          


Met Leu Glu Thr Tyr Lys Asn Leu Thr Ala Ile Gly Tyr Ile Trp Glu 
        35                  40                  45              


Glu His Thr Ile Glu Asp His Phe Gln Thr Ser Arg Ser His Gly Ser 
    50                  55                  60                  


Asn Lys Lys Thr His 
65                  


<210>  80
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  80

Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
1               5                   10                  15      


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
            20                  25                  30          


<210>  81
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  81

Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
1               5                   10                  15      


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
            20                  25                  30          


Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
        35                  40                  45              


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
    50                  55                  60                  


Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
65                  70                  75                  80  


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
                85                  90                  95      


Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
            100                 105                 110         


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
        115                 120                 125             


Ser Arg 
    130 


<210>  82
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Gln Ala Gly 
                165                 170                 175     


Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp Gly Gln Ala Ser 
            180                 185                 190         


Gly Val Glu Gly Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met 
        195                 200                 205             


Thr Ser Gln Glu Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln 
    210                 215                 220                 


Gln Thr Gln Lys Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu 
225                 230                 235                 240 


Trp Leu Asp Asn Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln 
                245                 250                 255     


Gln Leu Glu Ala Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val 
            260                 265                 270         


His Ser Tyr Leu Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys 
        275                 280                 285             


Arg Ile Lys Pro Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile 
    290                 295                 300                 


Gly Ser Gly Val Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe 
305                 310                 315                 320 


Gly Met Asp Val Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg 
                325                 330                 335     


Val Ala Thr Phe Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met 
            340                 345                 350         


Val Val Thr Gly Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln 
        355                 360                 365             


Val Asn Met Glu Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu 
    370                 375                 380                 


Ala Asn Gly Gln Ala Asp Thr Val Lys Val Pro Lys Glu Lys Asp Glu 
385                 390                 395                 400 


Met Val Glu Gln Glu Phe Asn Arg Leu Leu Glu Ala Thr Ser Tyr Leu 
                405                 410                 415     


Ser His Gln Leu Asp Phe Asn Val Leu Asn Asn Lys Pro Val Ser Leu 
            420                 425                 430         


Gly Gln Ala Leu Glu Val Val Ile Gln Leu Gln Glu Lys His Val Lys 
        435                 440                 445             


Asp Glu Gln Ile Glu His Trp Lys Lys Ile Val Lys Thr Gln Glu Glu 
    450                 455                 460                 


Leu Lys Glu Leu Leu Asn Lys Met Val Asn Leu Lys Glu Lys Ile Lys 
465                 470                 475                 480 


Glu Leu His Gln Gln Tyr Lys Glu Ala Ser Glu Val Lys Pro Pro Arg 
                485                 490                 495     


Asp Ile Thr Ala Glu Phe Leu Val Lys Ser Lys His Arg Asp Leu Thr 
            500                 505                 510         


Ala Leu Cys Lys Glu Tyr Asp Glu Leu Ala Glu Thr Gln Gly Lys Leu 
        515                 520                 525             


Glu Glu Lys Leu Gln Glu Leu Glu Ala Asn Pro Pro Ser Asp Val Tyr 
    530                 535                 540                 


Leu Ser Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu 
545                 550                 555                 560 


Glu Phe Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp 
                565                 570                 575     


Asp Gln Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg 
            580                 585                 590         


Asn Gly Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile 
        595                 600                 605             


Lys Leu Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys 
    610                 615                 620                 


Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr 
625                 630                 635                 640 


Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln 
                645                 650                 655     


Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr 
            660                 665                 670         


Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu 
        675                 680                 685             


Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His 
    690                 695                 700                 


Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn 
705                 710                 715                 720 


Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala 
                725                 730                 735     


Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu 
            740                 745                 750         


Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys 
        755                 760                 765             


Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser 
    770                 775                 780                 


Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met 
785                 790                 795                 800 


Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro 
                805                 810                 815     


Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro 
            820                 825                 830         


Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg 
        835                 840                 845             


Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala 
    850                 855                 860                 


Thr Pro Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
865                 870                 875     


<210>  83
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210>  84
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  84

Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu 
1               5                   10                  15      


Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala 
            20                  25                  30          


Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Ala Leu Ile Lys 
        35                  40                  45              


Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser His Arg Val Ala Asp 
    50                  55                  60                  


His Ala Gln Val Val Arg Val Leu Gly Phe Phe Gln Cys His Ser His 
65                  70                  75                  80  


Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln Phe Gly Met Ser Gly 
                85                  90                  95      


Gly Gly Ser Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys 
            100                 105                 110         


Asp Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala 
        115                 120                 125             


Ala Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala 
    130                 135                 140                 


Ile Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser 
145                 150                 155                 160 


His Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu 
                165                 170                 175     


Glu Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro 
            180                 185                 190         


Thr Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu 
        195                 200                 205             


Pro Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser 
    210                 215                 220                 


Tyr Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg 
225                 230                 235                 240 


Thr Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe 
                245                 250                 255     


Ser Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly 
            260                 265                 270         


Arg Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu 
        275                 280                 285             


His Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu 
    290                 295                 300                 


Ala Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val 
305                 310                 315                 320 


Glu Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly 
                325                 330                 335     


Arg Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro 
            340                 345                 350         


His Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr 
        355                 360                 365             


Leu Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu 
    370                 375                 380                 


Gln Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe 
385                 390                 395                 400 


Gly Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu 
                405                 410                 415     


Val Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val 
            420                 425                 430         


Pro Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala 
        435                 440                 445             


His Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg 
    450                 455                 460                 


Lys Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro 
465                 470                 475                 480 


Thr Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu 
                485                 490                 495     


Thr Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr 
            500                 505                 510         


Ser Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly 
        515                 520                 525             


Phe Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys 
    530                 535                 540                 


Asn Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro 
545                 550                 555                 560 


His Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala 
                565                 570                 575     


Ala Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro 
            580                 585                 590         


Thr Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser 
        595                 600                 605             


Thr Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro 
    610                 615                 620                 


Ser Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu 
625                 630                 635                 640 


Asp Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu 
                645                 650                 655     


Ser Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp 
            660                 665                 670         


Glu Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly 
        675                 680                 685             


Gly Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala 
    690                 695                 700                 


Arg Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn 
705                 710                 715                 720 


His Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn 
                725                 730                 735     


Lys Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys 
            740                 745                 750         


Glu Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala 
        755                 760                 765             


Ala Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln 
    770                 775                 780                 


Ile Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr 
785                 790                 795                 800 


Val Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp 
                805                 810                 815     


Val 
    


<210>  85
<211>  340
<212>  PRT
<213>  X. laevis

<400>  85

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Ser Arg 
1               5                   10                  15      


Val Val Lys Pro Lys Val Ala Ser Met Glu Glu Met Ala Ala Phe His 
            20                  25                  30          


Thr Asp Ala Tyr Leu Gln His Leu His Lys Val Ser Glu Glu Gly Asp 
        35                  40                  45              


Asn Asp Asp Pro Glu Thr Leu Glu Tyr Gly Leu Gly Tyr Asp Cys Pro 
    50                  55                  60                  


Ile Thr Glu Gly Ile Tyr Asp Tyr Ala Ala Ala Val Gly Gly Ala Thr 
65                  70                  75                  80  


Leu Thr Ala Ala Glu Gln Leu Ile Glu Gly Lys Thr Arg Ile Ala Val 
                85                  90                  95      


Asn Trp Pro Gly Gly Trp His His Ala Lys Lys Asp Glu Ala Ser Gly 
            100                 105                 110         


Phe Cys Tyr Leu Asn Asp Ala Val Leu Gly Ile Leu Lys Leu Arg Glu 
        115                 120                 125             


Lys Phe Asp Arg Val Leu Tyr Val Asp Met Asp Leu His His Gly Asp 
    130                 135                 140                 


Gly Val Glu Asp Ala Phe Ser Phe Thr Ser Lys Val Met Thr Val Ser 
145                 150                 155                 160 


Leu His Lys Phe Ser Pro Gly Phe Phe Pro Gly Thr Gly Asp Val Ser 
                165                 170                 175     


Asp Ile Gly Leu Gly Lys Gly Arg Tyr Tyr Ser Ile Asn Val Pro Leu 
            180                 185                 190         


Gln Asp Gly Ile Gln Asp Asp Lys Tyr Tyr Gln Ile Cys Glu Gly Val 
        195                 200                 205             


Leu Lys Glu Val Phe Thr Thr Phe Asn Pro Glu Ala Val Val Leu Gln 
    210                 215                 220                 


Leu Gly Ala Asp Thr Ile Ala Gly Asp Pro Met Cys Ser Phe Asn Met 
225                 230                 235                 240 


Thr Pro Glu Gly Ile Gly Lys Cys Leu Lys Tyr Val Leu Gln Trp Gln 
                245                 250                 255     


Leu Pro Thr Leu Ile Leu Gly Gly Gly Gly Tyr His Leu Pro Asn Thr 
            260                 265                 270         


Ala Arg Cys Trp Thr Tyr Leu Thr Ala Leu Ile Val Gly Arg Thr Leu 
        275                 280                 285             


Ser Ser Glu Ile Pro Asp His Glu Phe Phe Thr Glu Tyr Gly Pro Asp 
    290                 295                 300                 


Tyr Val Leu Glu Ile Thr Pro Ser Cys Arg Pro Asp Arg Asn Asp Thr 
305                 310                 315                 320 


Gln Lys Val Gln Glu Ile Leu Gln Ser Ile Lys Gly Asn Leu Lys Arg 
                325                 330                 335     


Val Val Glu Phe 
            340 


<210>  86
<211>  337
<212>  PRT
<213>  S. cerevisiae

<400>  86

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Arg Arg Val 
1               5                   10                  15      


Ala Tyr Phe Tyr Asp Ala Asp Val Gly Asn Tyr Ala Tyr Gly Ala Gly 
            20                  25                  30          


His Pro Met Lys Pro His Arg Ile Arg Met Ala His Ser Leu Ile Met 
        35                  40                  45              


Asn Tyr Gly Leu Tyr Lys Lys Met Glu Ile Tyr Arg Ala Lys Pro Ala 
    50                  55                  60                  


Thr Lys Gln Glu Met Cys Gln Phe His Thr Asp Glu Tyr Ile Asp Phe 
65                  70                  75                  80  


Leu Ser Arg Val Thr Pro Asp Asn Leu Glu Met Phe Lys Arg Glu Ser 
                85                  90                  95      


Val Lys Phe Asn Val Gly Asp Asp Cys Pro Val Phe Asp Gly Leu Tyr 
            100                 105                 110         


Glu Tyr Cys Ser Ile Ser Gly Gly Gly Ser Met Glu Gly Ala Ala Arg 
        115                 120                 125             


Leu Asn Arg Gly Lys Cys Asp Val Ala Val Asn Tyr Ala Gly Gly Leu 
    130                 135                 140                 


His His Ala Lys Lys Ser Glu Ala Ser Gly Phe Cys Tyr Leu Asn Asp 
145                 150                 155                 160 


Ile Val Leu Gly Ile Ile Glu Leu Leu Arg Tyr His Pro Arg Val Leu 
                165                 170                 175     


Tyr Ile Asp Ile Asp Val His His Gly Asp Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Tyr Thr Thr Asp Arg Val Met Thr Cys Ser Phe His Lys Tyr Gly Glu 
        195                 200                 205             


Phe Phe Pro Gly Thr Gly Glu Leu Arg Asp Ile Gly Val Gly Ala Gly 
    210                 215                 220                 


Lys Asn Tyr Ala Val Asn Val Pro Leu Arg Asp Gly Ile Asp Asp Ala 
225                 230                 235                 240 


Thr Tyr Arg Ser Val Phe Glu Pro Val Ile Lys Lys Ile Met Glu Trp 
                245                 250                 255     


Tyr Gln Pro Ser Ala Val Val Leu Gln Cys Gly Gly Asp Ser Leu Ser 
            260                 265                 270         


Gly Asp Arg Leu Gly Cys Phe Asn Leu Ser Met Glu Gly His Ala Asn 
        275                 280                 285             


Cys Val Asn Tyr Val Lys Ser Phe Gly Ile Pro Met Met Val Val Gly 
    290                 295                 300                 


Gly Gly Gly Tyr Thr Met Arg Asn Val Ala Arg Thr Trp Cys Phe Glu 
305                 310                 315                 320 


Thr Gly Leu Leu Asn Asn Val Val Leu Asp Lys Asp Leu Pro Tyr Glu 
                325                 330                 335     


Phe 
    


<210>  87
<211>  315
<212>  PRT
<213>  M. loti

<400>  87

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Pro Leu 
1               5                   10                  15      


Gln Ile Val His His Pro Asp Tyr Asp Ala Gly Phe Ala Thr Asn His 
            20                  25                  30          


Arg Phe Pro Met Ser Lys Tyr Pro Leu Leu Met Glu Ala Leu Arg Ala 
        35                  40                  45              


Arg Gly Leu Ala Ser Pro Asp Ala Leu Asn Thr Thr Glu Pro Ala Pro 
    50                  55                  60                  


Ala Ser Trp Leu Lys Leu Ala His Ala Ala Asp Tyr Val Asp Gln Val 
65                  70                  75                  80  


Ile Ser Cys Ser Val Pro Glu Lys Ile Glu Arg Glu Ile Gly Phe Pro 
                85                  90                  95      


Val Gly Pro Arg Val Ser Leu Arg Ala Gln Leu Ala Thr Gly Gly Thr 
            100                 105                 110         


Ile Leu Ala Ala Arg Leu Ala Leu Arg His Gly Ile Ala Cys Asn Thr 
        115                 120                 125             


Ala Gly Gly Ser His His Ala Arg Arg Ala Gln Gly Ala Gly Phe Cys 
    130                 135                 140                 


Thr Phe Asn Asp Val Ala Val Ala Ser Leu Val Leu Leu Asp Glu Gly 
145                 150                 155                 160 


Ala Ala Gln Asn Ile Leu Val Val Asp Leu Asp Val His Gln Gly Asp 
                165                 170                 175     


Gly Thr Ala Asp Ile Leu Ser Asp Glu Pro Gly Val Phe Thr Phe Ser 
            180                 185                 190         


Met His Gly Glu Arg Asn Tyr Pro Val Arg Lys Ile Ala Ser Asp Leu 
        195                 200                 205             


Asp Ile Ala Leu Pro Asp Gly Thr Gly Asp Ala Ala Tyr Leu Arg Arg 
    210                 215                 220                 


Leu Ala Thr Ile Leu Pro Glu Leu Ser Ala Arg Ala Arg Trp Asp Ile 
225                 230                 235                 240 


Val Phe Tyr Asn Ala Gly Val Asp Val His Ala Glu Asp Arg Leu Gly 
                245                 250                 255     


Arg Leu Ala Leu Ser Asn Gly Gly Leu Arg Ala Arg Asp Glu Met Val 
            260                 265                 270         


Ile Gly His Phe Arg Ala Leu Gly Ile Pro Val Cys Gly Val Ile Gly 
        275                 280                 285             


Gly Gly Tyr Ser Thr Asp Val Pro Ala Leu Ala Ser Arg His Ala Ile 
    290                 295                 300                 


Leu Phe Glu Val Ala Ser Thr Tyr Ala Glu Phe 
305                 310                 315 


<210>  88
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  88

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Leu His 
1               5                   10                  15      


Thr Thr Gln Leu Tyr Gln His Val Pro Glu Thr Arg Trp Pro Ile Val 
            20                  25                  30          


Tyr Ser Pro Arg Tyr Asn Ile Thr Phe Met Gly Leu Glu Lys Leu His 
        35                  40                  45              


Pro Phe Asp Ala Gly Lys Trp Gly Lys Val Ile Asn Phe Leu Lys Glu 
    50                  55                  60                  


Glu Lys Leu Leu Ser Asp Ser Met Leu Val Glu Ala Arg Glu Ala Ser 
65                  70                  75                  80  


Glu Glu Asp Leu Leu Val Val His Thr Arg Arg Tyr Leu Asn Glu Leu 
                85                  90                  95      


Lys Trp Ser Phe Ala Val Ala Thr Ile Thr Glu Ile Pro Pro Val Ile 
            100                 105                 110         


Phe Leu Pro Asn Phe Leu Val Gln Arg Lys Val Leu Arg Pro Leu Arg 
        115                 120                 125             


Thr Gln Thr Gly Gly Thr Ile Met Ala Gly Lys Leu Ala Val Glu Arg 
    130                 135                 140                 


Gly Trp Ala Ile Asn Val Gly Gly Gly Phe His His Cys Ser Ser Asp 
145                 150                 155                 160 


Arg Gly Gly Gly Phe Cys Ala Tyr Ala Asp Ile Thr Leu Ala Ile Lys 
                165                 170                 175     


Phe Leu Phe Glu Arg Val Glu Gly Ile Ser Arg Ala Thr Ile Ile Asp 
            180                 185                 190         


Leu Asp Ala His Gln Gly Asn Gly His Glu Arg Asp Phe Met Asp Asp 
        195                 200                 205             


Lys Arg Val Tyr Ile Met Asp Val Tyr Asn Arg His Ile Tyr Pro Gly 
    210                 215                 220                 


Asp Arg Phe Ala Lys Gln Ala Ile Arg Arg Lys Val Glu Leu Glu Trp 
225                 230                 235                 240 


Gly Thr Glu Asp Asp Glu Tyr Leu Asp Lys Val Glu Arg Asn Ile Lys 
                245                 250                 255     


Lys Ser Leu Gln Glu His Leu Pro Asp Val Val Val Tyr Asn Ala Gly 
            260                 265                 270         


Thr Asp Ile Leu Glu Gly Asp Arg Leu Gly Gly Leu Ser Ile Ser Pro 
        275                 280                 285             


Ala Gly Ile Val Lys Arg Asp Glu Leu Val Phe Arg Met Val Arg Gly 
    290                 295                 300                 


Arg Arg Val Pro Ile Leu Met Val Thr Ser Gly Gly Tyr Gln Lys Arg 
305                 310                 315                 320 


Thr Ala Arg Ile Ile Ala Asp Ser Ile Leu Asn Leu Phe Gly Leu Gly 
                325                 330                 335     


Leu Ile Gly Pro Glu Ser Pro Ser Val Ser Ala Gln Asn Ser Asp Thr 
            340                 345                 350         


Pro Leu Leu Pro Pro Ala Val Pro Glu Phe 
        355                 360         


<210>  89
<211>  226
<212>  PRT
<213>  A. thaliana

<400>  89

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Phe 
1               5                   10                  15      


Trp Gly Ile Glu Val Lys Ser Gly Lys Pro Val Thr Val Thr Pro Glu 
            20                  25                  30          


Glu Gly Ile Leu Ile His Val Ser Gln Ala Ser Leu Gly Glu Cys Lys 
        35                  40                  45              


Asn Lys Lys Gly Glu Phe Val Pro Leu His Val Lys Val Gly Asn Gln 
    50                  55                  60                  


Asn Leu Val Leu Gly Thr Leu Ser Thr Glu Asn Ile Pro Gln Leu Phe 
65                  70                  75                  80  


Cys Asp Leu Val Phe Asp Lys Glu Phe Glu Leu Ser His Thr Trp Gly 
                85                  90                  95      


Lys Gly Ser Val Tyr Phe Val Gly Tyr Lys Thr Pro Asn Ile Glu Pro 
            100                 105                 110         


Gln Gly Tyr Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Pro Ala 
        115                 120                 125             


Gly Asn Ala Ala Lys Ala Val Ala Lys Pro Lys Ala Lys Pro Ala Glu 
    130                 135                 140                 


Val Lys Pro Ala Val Asp Asp Glu Glu Asp Glu Ser Asp Ser Asp Gly 
145                 150                 155                 160 


Met Asp Glu Asp Asp Ser Asp Gly Glu Asp Ser Glu Glu Glu Glu Pro 
                165                 170                 175     


Thr Pro Lys Lys Pro Ala Ser Ser Lys Lys Arg Ala Asn Glu Thr Thr 
            180                 185                 190         


Pro Lys Ala Pro Val Ser Ala Lys Lys Ala Lys Val Ala Val Thr Pro 
        195                 200                 205             


Gln Lys Thr Asp Glu Lys Lys Lys Gly Gly Lys Ala Ala Asn Gln Ser 
    210                 215                 220                 


Glu Phe 
225     


<210>  90
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  90

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Val Gly 
1               5                   10                  15      


Ala Gly Ile Ser Thr Pro Ser Gly Ile Pro Asp Phe Arg Ser Pro Gly 
            20                  25                  30          


Ser Gly Leu Tyr Ser Asn Leu Gln Gln Tyr Asp Leu Pro Tyr Pro Glu 
        35                  40                  45              


Ala Ile Phe Glu Leu Pro Phe Phe Phe His Asn Pro Lys Pro Phe Phe 
    50                  55                  60                  


Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn Tyr Lys Pro Asn Val Thr 
65                  70                  75                  80  


His Tyr Phe Leu Arg Leu Leu His Asp Lys Gly Leu Leu Leu Arg Leu 
                85                  90                  95      


Tyr Thr Gln Asn Ile Asp Gly Leu Glu Arg Val Ser Gly Ile Pro Ala 
            100                 105                 110         


Ser Lys Leu Val Glu Ala His Gly Thr Phe Ala Ser Ala Thr Cys Thr 
        115                 120                 125             


Val Cys Gln Arg Pro Phe Pro Gly Glu Asp Ile Arg Ala Asp Val Met 
    130                 135                 140                 


Ala Asp Arg Val Pro Arg Cys Pro Val Cys Thr Gly Val Val Lys Pro 
145                 150                 155                 160 


Asp Ile Val Phe Phe Gly Glu Pro Leu Pro Gln Arg Phe Leu Leu His 
                165                 170                 175     


Val Val Asp Phe Pro Met Ala Asp Leu Leu Leu Ile Leu Gly Thr Ser 
            180                 185                 190         


Leu Glu Val Glu Pro Phe Ala Ser Leu Thr Glu Ala Val Arg Ser Ser 
        195                 200                 205             


Val Pro Arg Leu Leu Ile Asn Arg Asp Leu Val Gly Pro Leu Ala Trp 
    210                 215                 220                 


His Pro Arg Ser Arg Asp Val Ala Gln Leu Gly Asp Val Val His Gly 
225                 230                 235                 240 


Val Glu Ser Leu Val Glu Leu Leu Gly Trp Thr Glu Glu Met Arg Asp 
                245                 250                 255     


Leu Val Gln Arg Glu Thr Gly Lys Leu Asp Gly Pro Asp Lys Glu Phe 
            260                 265                 270         


<210>  91
<211>  306
<212>  PRT
<213>  S. cerevisiae

<400>  91

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Thr Glu Met 
1               5                   10                  15      


Ser Val Arg Lys Ile Ala Ala His Met Lys Ser Asn Pro Asn Ala Lys 
            20                  25                  30          


Val Ile Phe Met Val Gly Ala Gly Ile Ser Thr Ser Cys Gly Ile Pro 
        35                  40                  45              


Asp Phe Arg Ser Pro Gly Thr Gly Leu Tyr His Asn Leu Ala Arg Leu 
    50                  55                  60                  


Lys Leu Pro Tyr Pro Glu Ala Val Phe Asp Val Asp Phe Phe Gln Ser 
65                  70                  75                  80  


Asp Pro Leu Pro Phe Tyr Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn 
                85                  90                  95      


Phe Arg Pro Ser Lys Phe His Tyr Leu Leu Lys Leu Phe Gln Asp Lys 
            100                 105                 110         


Asp Val Leu Lys Arg Val Tyr Thr Gln Asn Ile Asp Thr Leu Glu Arg 
        115                 120                 125             


Gln Ala Gly Val Lys Asp Asp Leu Ile Ile Glu Ala His Gly Ser Phe 
    130                 135                 140                 


Ala His Cys His Cys Ile Gly Cys Gly Lys Val Tyr Pro Pro Gln Val 
145                 150                 155                 160 


Phe Lys Ser Lys Leu Ala Glu His Pro Ile Lys Asp Phe Val Lys Cys 
                165                 170                 175     


Asp Val Cys Gly Glu Leu Val Lys Pro Ala Ile Val Phe Phe Gly Glu 
            180                 185                 190         


Asp Leu Pro Asp Ser Phe Ser Glu Thr Trp Leu Asn Asp Ser Glu Trp 
        195                 200                 205             


Leu Arg Glu Lys Ile Thr Thr Ser Gly Lys His Pro Gln Gln Pro Leu 
    210                 215                 220                 


Val Ile Val Val Gly Thr Ser Leu Ala Val Tyr Pro Phe Ala Ser Leu 
225                 230                 235                 240 


Pro Glu Glu Ile Pro Arg Lys Val Lys Arg Val Leu Cys Asn Leu Glu 
                245                 250                 255     


Thr Val Gly Asp Phe Lys Ala Asn Lys Arg Pro Thr Asp Leu Ile Val 
            260                 265                 270         


His Gln Tyr Ser Asp Glu Phe Ala Glu Gln Leu Val Glu Glu Leu Gly 
        275                 280                 285             


Trp Gln Glu Asp Phe Glu Lys Ile Leu Thr Ala Gln Gly Gly Met Gly 
    290                 295                 300                 


Glu Phe 
305     


<210>  92
<211>  257
<212>  PRT
<213>  E. coli

<400>  92

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Lys 
1               5                   10                  15      


Pro Arg Val Leu Val Leu Thr Gly Ala Gly Ile Ser Ala Glu Ser Gly 
            20                  25                  30          


Ile Arg Thr Phe Arg Ala Ala Asp Gly Leu Trp Glu Glu His Arg Val 
        35                  40                  45              


Glu Asp Val Ala Thr Pro Glu Gly Phe Asp Arg Asp Pro Glu Leu Val 
    50                  55                  60                  


Gln Ala Phe Tyr Asn Ala Arg Arg Arg Gln Leu Gln Gln Pro Glu Ile 
65                  70                  75                  80  


Gln Pro Asn Ala Ala His Leu Ala Leu Ala Lys Leu Gln Asp Ala Leu 
                85                  90                  95      


Gly Asp Arg Phe Leu Leu Val Thr Gln Asn Ile Asp Asn Leu His Glu 
            100                 105                 110         


Arg Ala Gly Asn Thr Asn Val Ile His Met His Gly Glu Leu Leu Lys 
        115                 120                 125             


Val Arg Cys Ser Gln Ser Gly Gln Val Leu Asp Trp Thr Gly Asp Val 
    130                 135                 140                 


Thr Pro Glu Asp Lys Cys His Cys Cys Gln Phe Pro Ala Pro Leu Arg 
145                 150                 155                 160 


Pro His Val Val Trp Phe Gly Glu Met Pro Leu Gly Met Asp Glu Ile 
                165                 170                 175     


Tyr Met Ala Leu Ser Met Ala Asp Ile Phe Ile Ala Ile Gly Thr Ser 
            180                 185                 190         


Gly His Val Tyr Pro Ala Ala Gly Phe Val His Glu Ala Lys Leu His 
        195                 200                 205             


Gly Ala His Thr Val Glu Leu Asn Leu Glu Pro Ser Gln Val Gly Asn 
    210                 215                 220                 


Glu Phe Ala Glu Lys Tyr Tyr Gly Pro Ala Ser Gln Val Val Pro Glu 
225                 230                 235                 240 


Phe Val Glu Lys Leu Leu Lys Gly Leu Lys Ala Gly Ser Ile Ala Glu 
                245                 250                 255     


Phe 
    


<210>  93
<211>  346
<212>  PRT
<213>  C. albicans

<400>  93

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Pro Ser 
1               5                   10                  15      


Leu Asp Asp Ile Leu Lys Pro Val Ala Glu Ala Val Lys Asn Gly Lys 
            20                  25                  30          


Lys Val Thr Phe Phe Asn Gly Ala Gly Ile Ser Thr Gly Ala Gly Ile 
        35                  40                  45              


Pro Asp Phe Arg Ser Pro Asp Thr Gly Leu Tyr Ala Asn Leu Ala Lys 
    50                  55                  60                  


Leu Asn Leu Pro Phe Ala Glu Ala Val Phe Asp Ile Asp Phe Phe Lys 
65                  70                  75                  80  


Glu Asp Pro Lys Pro Phe Tyr Thr Leu Ala Glu Glu Leu Tyr Pro Gly 
                85                  90                  95      


Asn Phe Ala Pro Thr Lys Phe His His Phe Ile Lys Leu Leu Gln Asp 
            100                 105                 110         


Gln Gly Ser Leu Lys Arg Val Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
        115                 120                 125             


Arg Leu Ala Gly Val Glu Asp Lys Tyr Ile Val Glu Ala His Gly Ser 
    130                 135                 140                 


Phe Ala Ser Asn His Cys Val Asp Cys His Lys Glu Met Thr Thr Glu 
145                 150                 155                 160 


Thr Leu Lys Thr Tyr Met Lys Asp Lys Lys Ile Pro Ser Cys Gln His 
                165                 170                 175     


Cys Glu Gly Tyr Val Lys Pro Asp Ile Val Phe Phe Gly Glu Gly Leu 
            180                 185                 190         


Pro Val Lys Phe Phe Asp Leu Trp Glu Asp Asp Cys Glu Asp Val Glu 
        195                 200                 205             


Val Ala Ile Val Ala Gly Thr Ser Leu Thr Val Phe Pro Phe Ala Ser 
    210                 215                 220                 


Leu Pro Gly Glu Val Asn Lys Lys Cys Leu Arg Val Leu Val Asn Lys 
225                 230                 235                 240 


Glu Lys Val Gly Thr Phe Lys His Glu Pro Arg Lys Ser Asp Ile Ile 
                245                 250                 255     


Ala Leu His Asp Cys Asp Ile Val Ala Glu Arg Leu Cys Thr Leu Leu 
            260                 265                 270         


Gly Leu Asp Asp Lys Leu Asn Glu Val Tyr Glu Lys Glu Lys Ile Lys 
        275                 280                 285             


Tyr Ser Lys Ala Glu Thr Lys Glu Ile Lys Met His Glu Ile Glu Asp 
    290                 295                 300                 


Lys Leu Lys Glu Glu Ala His Leu Lys Glu Asp Lys His Thr Thr Lys 
305                 310                 315                 320 


Val Asp Lys Lys Glu Lys Gln Asn Asp Ala Asn Asp Lys Glu Leu Glu 
                325                 330                 335     


Gln Leu Ile Asp Lys Ala Lys Ala Glu Phe 
            340                 345     


<210>  94
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  94

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ser Ser Ser 
1               5                   10                  15      


Met Ala Asp Phe Arg Lys Phe Phe Ala Lys Ala Lys His Ile Val Ile 
            20                  25                  30          


Ile Ser Gly Ala Gly Val Ser Ala Glu Ser Gly Val Pro Thr Phe Arg 
        35                  40                  45              


Gly Ala Gly Gly Tyr Trp Arg Lys Trp Gln Ala Gln Asp Leu Ala Thr 
    50                  55                  60                  


Pro Leu Ala Phe Ala His Asn Pro Ser Arg Val Trp Glu Phe Tyr His 
65                  70                  75                  80  


Tyr Arg Arg Glu Val Met Gly Ser Lys Glu Pro Asn Ala Gly His Arg 
                85                  90                  95      


Ala Ile Ala Glu Cys Glu Thr Arg Leu Gly Lys Gln Gly Arg Arg Val 
            100                 105                 110         


Val Val Ile Thr Gln Asn Ile Asp Glu Leu His Arg Lys Ala Gly Thr 
        115                 120                 125             


Lys Asn Leu Leu Glu Ile His Gly Ser Leu Phe Lys Thr Arg Cys Thr 
    130                 135                 140                 


Ser Cys Gly Val Val Ala Glu Asn Tyr Lys Ser Pro Ile Cys Pro Ala 
145                 150                 155                 160 


Leu Ser Gly Lys Gly Ala Pro Glu Pro Gly Thr Gln Asp Ala Ser Ile 
                165                 170                 175     


Pro Val Glu Lys Leu Pro Arg Cys Glu Glu Ala Gly Cys Gly Gly Leu 
            180                 185                 190         


Leu Arg Pro His Val Val Trp Phe Gly Glu Asn Leu Asp Pro Ala Ile 
        195                 200                 205             


Leu Glu Glu Val Asp Arg Glu Leu Ala His Cys Asp Leu Cys Leu Val 
    210                 215                 220                 


Val Gly Thr Ser Ser Val Val Tyr Pro Ala Ala Met Phe Ala Pro Gln 
225                 230                 235                 240 


Val Ala Ala Arg Gly Val Pro Val Ala Glu Phe Asn Thr Glu Thr Thr 
                245                 250                 255     


Pro Ala Thr Asn Arg Phe Arg Phe His Phe Gln Gly Pro Cys Gly Thr 
            260                 265                 270         


Thr Leu Pro Glu Ala Leu Ala Cys His Glu Asn Glu Thr Val Ser Glu 
        275                 280                 285             


Phe 
    


<210>  95
<211>  288
<212>  PRT
<213>  P. falciparum

<400>  95

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Gly Asn 
1               5                   10                  15      


Leu Met Ile Ser Phe Leu Lys Lys Asp Thr Gln Ser Ile Thr Leu Glu 
            20                  25                  30          


Glu Leu Ala Lys Ile Ile Lys Lys Cys Lys His Val Val Ala Leu Thr 
        35                  40                  45              


Gly Ser Gly Thr Ser Ala Glu Ser Asn Ile Pro Ser Phe Arg Gly Ser 
    50                  55                  60                  


Ser Asn Ser Ile Trp Ser Lys Tyr Asp Pro Arg Ile Tyr Gly Thr Ile 
65                  70                  75                  80  


Trp Gly Phe Trp Lys Tyr Pro Glu Lys Ile Trp Glu Val Ile Arg Asp 
                85                  90                  95      


Ile Ser Ser Asp Tyr Glu Ile Glu Ile Asn Asn Gly His Val Ala Leu 
            100                 105                 110         


Ser Thr Leu Glu Ser Leu Gly Tyr Leu Lys Ser Val Val Thr Gln Asn 
        115                 120                 125             


Val Asp Gly Leu His Glu Ala Ser Gly Asn Thr Lys Val Ile Ser Leu 
    130                 135                 140                 


His Gly Asn Val Phe Glu Ala Val Cys Cys Thr Cys Asn Lys Ile Val 
145                 150                 155                 160 


Lys Leu Asn Lys Ile Met Leu Gln Lys Thr Ser His Phe Met His Gln 
                165                 170                 175     


Leu Pro Pro Glu Cys Pro Cys Gly Gly Ile Phe Lys Pro Asn Ile Ile 
            180                 185                 190         


Leu Phe Gly Glu Val Val Ser Ser Asp Leu Leu Lys Glu Ala Glu Glu 
        195                 200                 205             


Glu Ile Ala Lys Cys Asp Leu Leu Leu Val Ile Gly Thr Ser Ser Thr 
    210                 215                 220                 


Val Ser Thr Ala Thr Asn Leu Cys His Phe Ala Cys Lys Lys Lys Lys 
225                 230                 235                 240 


Lys Ile Val Glu Ile Asn Ile Ser Lys Thr Tyr Ile Thr Asn Lys Met 
                245                 250                 255     


Ser Asp Tyr His Val Cys Ala Lys Phe Ser Glu Leu Thr Lys Val Ala 
            260                 265                 270         


Asn Ile Leu Lys Gly Ser Ser Glu Lys Asn Lys Lys Ile Met Glu Phe 
        275                 280                 285             


<210>  96
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Ser Val 
1               5                   10                  15      


Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly Lys Cys Gly 
            20                  25                  30          


Leu Pro Glu Ile Phe Asp Pro Pro Glu Glu Leu Glu Arg Lys Val Trp 
        35                  40                  45              


Glu Leu Ala Arg Leu Val Trp Gln Ser Ser Ser Val Val Phe His Thr 
    50                  55                  60                  


Gly Ala Gly Ile Ser Thr Ala Ser Gly Ile Pro Asp Phe Arg Gly Pro 
65                  70                  75                  80  


His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro Lys Phe Asp 
                85                  90                  95      


Thr Thr Phe Glu Ser Ala Arg Pro Thr Gln Thr His Met Ala Leu Val 
            100                 105                 110         


Gln Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser Gln Asn Val 
        115                 120                 125             


Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys Leu Ala Glu 
    130                 135                 140                 


Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys Lys Thr Gln 
145                 150                 155                 160 


Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys Ala Thr Gly 
                165                 170                 175     


Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala Cys Arg Gly 
            180                 185                 190         


Glu Leu Arg Asp Thr Ile Leu Asp Trp Glu Asp Ser Leu Pro Asp Arg 
        195                 200                 205             


Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp Leu Ser Ile 
    210                 215                 220                 


Thr Leu Gly Thr Ser Leu Gln Ile Arg Pro Ser Gly Asn Leu Pro Leu 
225                 230                 235                 240 


Ala Thr Lys Arg Arg Gly Gly Arg Leu Val Ile Val Asn Leu Gln Pro 
                245                 250                 255     


Thr Lys His Asp Arg His Ala Asp Leu Arg Ile His Gly Tyr Val Asp 
            260                 265                 270         


Glu Val Met Thr Arg Leu Met Lys His Leu Gly Leu Glu Ile Pro Ala 
        275                 280                 285             


Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro Leu Glu Phe 
    290                 295                 300                 


<210>  97
<211>  234
<212>  PRT
<213>  C. trachomatis

<400>  97

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Thr Thr 
1               5                   10                  15      


Asn Ser Thr Gln Asp Thr Leu Tyr Leu Ser Leu His Gly Gly Ile Asp 
            20                  25                  30          


Ser Ala Ile Pro Tyr Pro Val Arg Arg Val Glu Gln Leu Leu Gln Phe 
        35                  40                  45              


Ser Phe Leu Pro Glu Leu Gln Phe Gln Asn Ala Ala Val Lys Gln Arg 
    50                  55                  60                  


Ile Gln Arg Leu Cys Tyr Arg Glu Glu Lys Arg Leu Ala Val Ser Ser 
65                  70                  75                  80  


Leu Ala Lys Trp Leu Gly Gln Leu His Lys Gln Arg Leu Arg Ala Pro 
                85                  90                  95      


Lys Asn Pro Pro Val Ala Ile Cys Trp Ile Asn Ser Tyr Val Gly Tyr 
            100                 105                 110         


Gly Val Phe Ala Arg Glu Ser Ile Pro Ala Trp Ser Tyr Ile Gly Glu 
        115                 120                 125             


Tyr Thr Gly Ile Leu Arg Arg Arg Gln Ala Leu Trp Leu Asp Glu Asn 
    130                 135                 140                 


Asp Tyr Cys Phe Arg Tyr Pro Val Pro Arg Tyr Ser Phe Arg Tyr Phe 
145                 150                 155                 160 


Thr Ile Asp Ser Gly Met Gln Gly Asn Val Thr Arg Phe Ile Asn His 
                165                 170                 175     


Ser Asp Asn Pro Asn Leu Glu Ala Ile Gly Ala Phe Glu Asn Gly Ile 
            180                 185                 190         


Phe His Ile Ile Ile Arg Ala Ile Lys Asp Ile Leu Pro Gly Glu Glu 
        195                 200                 205             


Leu Cys Tyr His Tyr Gly Pro Leu Tyr Trp Lys His Arg Lys Lys Arg 
    210                 215                 220                 


Glu Glu Phe Val Pro Gln Glu Glu Glu Phe 
225                 230                 


<210>  98
<211>  134
<212>  PRT
<213>  P. bursaria

<400>  98

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Phe Asn 
1               5                   10                  15      


Asp Arg Val Ile Val Lys Lys Ser Pro Leu Gly Gly Tyr Gly Val Phe 
            20                  25                  30          


Ala Arg Lys Ser Phe Glu Lys Gly Glu Leu Val Glu Glu Cys Leu Cys 
        35                  40                  45              


Ile Val Arg His Asn Asp Asp Trp Gly Thr Ala Leu Glu Asp Tyr Leu 
    50                  55                  60                  


Phe Ser Arg Lys Asn Met Ser Ala Met Ala Leu Gly Phe Gly Ala Ile 
65                  70                  75                  80  


Phe Asn His Ser Lys Asp Pro Asn Ala Arg His Glu Leu Thr Ala Gly 
                85                  90                  95      


Leu Lys Arg Met Arg Ile Phe Thr Ile Lys Pro Ile Ala Ile Gly Glu 
            100                 105                 110         


Glu Ile Thr Ile Ser Tyr Gly Asp Asp Tyr Trp Leu Ser Arg Pro Arg 
        115                 120                 125             


Leu Thr Gln Asn Glu Phe 
    130                 


<210>  99
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  99

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Asn Leu Lys 
1               5                   10                  15      


Cys Val Arg Ile Leu Lys Gln Phe His Lys Asp Leu Glu Arg Glu Leu 
            20                  25                  30          


Leu Arg Arg His His Arg Ser Lys Thr Pro Arg His Leu Asp Pro Ser 
        35                  40                  45              


Leu Ala Asn Tyr Leu Val Gln Lys Ala Lys Gln Arg Arg Ala Leu Arg 
    50                  55                  60                  


Arg Trp Glu Gln Glu Leu Asn Ala Lys Arg Ser His Leu Gly Arg Ile 
65                  70                  75                  80  


Thr Val Glu Asn Glu Val Asp Leu Asp Gly Pro Pro Arg Ala Phe Val 
                85                  90                  95      


Tyr Ile Asn Glu Tyr Arg Val Gly Glu Gly Ile Thr Leu Asn Gln Val 
            100                 105                 110         


Ala Val Gly Cys Glu Cys Gln Asp Cys Leu Trp Ala Pro Thr Gly Gly 
        115                 120                 125             


Cys Cys Pro Gly Ala Ser Leu His Lys Phe Ala Tyr Asn Asp Gln Gly 
    130                 135                 140                 


Gln Val Arg Leu Arg Ala Gly Leu Pro Ile Tyr Glu Cys Asn Ser Arg 
145                 150                 155                 160 


Cys Arg Cys Gly Tyr Asp Cys Pro Asn Arg Val Val Gln Lys Gly Ile 
                165                 170                 175     


Arg Tyr Asp Leu Cys Ile Phe Arg Thr Asp Asp Gly Arg Gly Trp Gly 
            180                 185                 190         


Val Arg Thr Leu Glu Lys Ile Arg Lys Asn Ser Phe Val Met Glu Tyr 
        195                 200                 205             


Val Gly Glu Ile Ile Thr Ser Glu Glu Ala Glu Arg Arg Gly Gln Ile 
    210                 215                 220                 


Tyr Asp Arg Gln Gly Ala Thr Tyr Leu Phe Asp Leu Asp Tyr Val Glu 
225                 230                 235                 240 


Asp Val Tyr Thr Val Asp Ala Ala Tyr Tyr Gly Asn Ile Ser His Phe 
                245                 250                 255     


Val Asn His Ser Cys Asp Pro Asn Leu Gln Val Tyr Asn Val Phe Ile 
            260                 265                 270         


Asp Asn Leu Asp Glu Arg Leu Pro Arg Ile Ala Phe Phe Ala Thr Arg 
        275                 280                 285             


Thr Ile Arg Ala Gly Glu Glu Leu Thr Phe Asp Tyr Asn Met Gln Val 
    290                 295                 300                 


Asp Pro Val Asp Met Glu Ser Thr Arg Met Asp Ser Asn Phe Gly Leu 
305                 310                 315                 320 


Ala Gly Leu Pro Gly Ser Pro Lys Lys Arg Val Arg Ile Glu Cys Lys 
                325                 330                 335     


Cys Gly Thr Glu Ser Cys Arg Lys Tyr Leu Phe Glu Phe 
            340                 345                 


<210>  100
<211>  346
<212>  PRT
<213>  N. crassa

<400>  100

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Lys 
1               5                   10                  15      


Ala Phe Arg Pro His Phe Phe Asn His Gly Lys Pro Asp Ala Asn Pro 
            20                  25                  30          


Lys Glu Lys Lys Asn Cys His Trp Cys Gln Ile Arg Ser Phe Ala Thr 
        35                  40                  45              


His Ala Gln Leu Pro Ile Ser Ile Val Asn Arg Glu Asp Asp Ala Phe 
    50                  55                  60                  


Leu Asn Pro Asn Phe Arg Phe Ile Asp His Ser Ile Ile Gly Lys Asn 
65                  70                  75                  80  


Val Pro Val Ala Asp Gln Ser Phe Arg Val Gly Cys Ser Cys Ala Ser 
                85                  90                  95      


Asp Glu Glu Cys Met Tyr Ser Thr Cys Gln Cys Leu Asp Glu Met Ala 
            100                 105                 110         


Pro Asp Ser Asp Glu Glu Ala Asp Pro Tyr Thr Arg Lys Lys Arg Phe 
        115                 120                 125             


Ala Tyr Tyr Ser Gln Gly Ala Lys Lys Gly Leu Leu Arg Asp Arg Val 
    130                 135                 140                 


Leu Gln Ser Gln Glu Pro Ile Tyr Glu Cys His Gln Gly Cys Ala Cys 
145                 150                 155                 160 


Ser Lys Asp Cys Pro Asn Arg Val Val Glu Arg Gly Arg Thr Val Pro 
                165                 170                 175     


Leu Gln Ile Phe Arg Thr Lys Asp Arg Gly Trp Gly Val Lys Cys Pro 
            180                 185                 190         


Val Asn Ile Lys Arg Gly Gln Phe Val Asp Arg Tyr Leu Gly Glu Ile 
        195                 200                 205             


Ile Thr Ser Glu Glu Ala Asp Arg Arg Arg Ala Glu Ser Thr Ile Ala 
    210                 215                 220                 


Arg Arg Lys Asp Val Tyr Leu Phe Ala Leu Asp Lys Phe Ser Asp Pro 
225                 230                 235                 240 


Asp Ser Leu Asp Pro Leu Leu Ala Gly Gln Pro Leu Glu Val Asp Gly 
                245                 250                 255     


Glu Tyr Met Ser Gly Pro Thr Arg Phe Ile Asn His Ser Cys Asp Pro 
            260                 265                 270         


Asn Met Ala Ile Phe Ala Arg Val Gly Asp His Ala Asp Lys His Ile 
        275                 280                 285             


His Asp Leu Ala Leu Phe Ala Ile Lys Asp Ile Pro Lys Gly Thr Glu 
    290                 295                 300                 


Leu Thr Phe Asp Tyr Val Asn Gly Leu Thr Gly Leu Glu Ser Asp Ala 
305                 310                 315                 320 


His Asp Pro Ser Lys Ile Ser Glu Met Thr Lys Cys Leu Cys Gly Thr 
                325                 330                 335     


Ala Lys Cys Arg Gly Tyr Leu Trp Glu Phe 
            340                 345     


<210>  101
<211>  282
<212>  PRT
<213>  A. thaliana

<400>  101

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Asp Ile Ser 
1               5                   10                  15      


Gly Gly Leu Glu Phe Lys Gly Ile Pro Ala Thr Asn Arg Val Asp Asp 
            20                  25                  30          


Ser Pro Val Ser Pro Thr Ser Gly Phe Thr Tyr Ile Lys Ser Leu Ile 
        35                  40                  45              


Ile Glu Pro Asn Val Ile Ile Pro Lys Ser Ser Thr Gly Cys Asn Cys 
    50                  55                  60                  


Arg Gly Ser Cys Thr Asp Ser Lys Lys Cys Ala Cys Ala Lys Leu Asn 
65                  70                  75                  80  


Gly Gly Asn Phe Pro Tyr Val Asp Leu Asn Asp Gly Arg Leu Ile Glu 
                85                  90                  95      


Ser Arg Asp Val Val Phe Glu Cys Gly Pro His Cys Gly Cys Gly Pro 
            100                 105                 110         


Lys Cys Val Asn Arg Thr Ser Gln Lys Arg Leu Arg Phe Asn Leu Glu 
        115                 120                 125             


Val Phe Arg Ser Ala Lys Lys Gly Trp Ala Val Arg Ser Trp Glu Tyr 
    130                 135                 140                 


Ile Pro Ala Gly Ser Pro Val Cys Glu Tyr Ile Gly Val Val Arg Arg 
145                 150                 155                 160 


Thr Ala Asp Val Asp Thr Ile Ser Asp Asn Glu Tyr Ile Phe Glu Ile 
                165                 170                 175     


Asp Cys Gln Gln Thr Met Gln Gly Leu Gly Gly Arg Gln Arg Arg Leu 
            180                 185                 190         


Arg Asp Val Ala Val Pro Met Asn Asn Gly Val Ser Gln Ser Ser Glu 
        195                 200                 205             


Asp Glu Asn Ala Pro Glu Phe Cys Ile Asp Ala Gly Ser Thr Gly Asn 
    210                 215                 220                 


Phe Ala Arg Phe Ile Asn His Ser Cys Glu Pro Asn Leu Phe Val Gln 
225                 230                 235                 240 


Cys Val Leu Ser Ser His Gln Asp Ile Arg Leu Ala Arg Val Val Leu 
                245                 250                 255     


Phe Ala Ala Asp Asn Ile Ser Pro Met Gln Glu Leu Thr Tyr Asp Tyr 
            260                 265                 270         


Gly Tyr Ala Leu Asp Ser Val His Glu Phe 
        275                 280         


<210>  102
<211>  328
<212>  PRT
<213>  A. thaliana

<400>  102

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Gln Ser Ala 
1               5                   10                  15      


Tyr Leu His Val Ser Leu Ala Arg Ile Ser Asp Glu Asp Cys Cys Ala 
            20                  25                  30          


Asn Cys Lys Gly Asn Cys Leu Ser Ala Asp Phe Pro Cys Thr Cys Ala 
        35                  40                  45              


Arg Glu Thr Ser Gly Glu Tyr Ala Tyr Thr Lys Glu Gly Leu Leu Lys 
    50                  55                  60                  


Glu Lys Phe Leu Asp Thr Cys Leu Lys Met Lys Lys Glu Pro Asp Ser 
65                  70                  75                  80  


Phe Pro Lys Val Tyr Cys Lys Asp Cys Pro Leu Glu Arg Asp His Asp 
                85                  90                  95      


Lys Gly Thr Tyr Gly Lys Cys Asp Gly His Leu Ile Arg Lys Phe Ile 
            100                 105                 110         


Lys Glu Cys Trp Arg Lys Cys Gly Cys Asp Met Gln Cys Gly Asn Arg 
        115                 120                 125             


Val Val Gln Arg Gly Ile Arg Cys Gln Leu Gln Val Tyr Phe Thr Gln 
    130                 135                 140                 


Glu Gly Lys Gly Trp Gly Leu Arg Thr Leu Gln Asp Leu Pro Lys Gly 
145                 150                 155                 160 


Thr Phe Ile Cys Glu Tyr Ile Gly Glu Ile Leu Thr Asn Thr Glu Leu 
                165                 170                 175     


Tyr Asp Arg Asn Val Arg Ser Ser Ser Glu Arg His Thr Tyr Pro Val 
            180                 185                 190         


Thr Leu Asp Ala Asp Trp Gly Ser Glu Lys Asp Leu Lys Asp Glu Glu 
        195                 200                 205             


Ala Leu Cys Leu Asp Ala Thr Ile Cys Gly Asn Val Ala Arg Phe Ile 
    210                 215                 220                 


Asn His Arg Cys Glu Asp Ala Asn Met Ile Asp Ile Pro Ile Glu Ile 
225                 230                 235                 240 


Glu Thr Pro Asp Arg His Tyr Tyr His Ile Ala Phe Phe Thr Leu Arg 
                245                 250                 255     


Asp Val Lys Ala Met Asp Glu Leu Thr Trp Asp Tyr Met Ile Asp Phe 
            260                 265                 270         


Asn Asp Lys Ser His Pro Val Lys Ala Phe Arg Cys Cys Cys Gly Ser 
        275                 280                 285             


Glu Ser Cys Arg Asp Arg Lys Ile Lys Gly Ser Gln Gly Lys Ser Ile 
    290                 295                 300                 


Glu Arg Arg Lys Ile Val Ser Ala Lys Lys Gln Gln Gly Ser Lys Glu 
305                 310                 315                 320 


Val Ser Lys Lys Arg Lys Glu Phe 
                325             


<210>  103
<211>  303
<212>  PRT
<213>  C. elegans

<400>  103

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Gln Leu 
1               5                   10                  15      


His Glu Gln Ile Ala Asn Ile Ser Val Thr Phe Asn Asp Ile Pro Arg 
            20                  25                  30          


Ser Asp His Ser Met Thr Pro Thr Glu Leu Cys Tyr Phe Asp Asp Phe 
        35                  40                  45              


Ala Thr Thr Leu Val Val Asp Ser Val Leu Asn Phe Thr Thr His Lys 
    50                  55                  60                  


Met Ser Lys Lys Arg Arg Tyr Leu Tyr Gln Asp Glu Tyr Arg Thr Ala 
65                  70                  75                  80  


Arg Thr Val Met Lys Thr Phe Arg Glu Gln Arg Asp Trp Thr Asn Ala 
                85                  90                  95      


Ile Tyr Gly Leu Leu Thr Leu Arg Ser Val Ser His Phe Leu Ser Lys 
            100                 105                 110         


Leu Pro Pro Asn Lys Leu Phe Glu Phe Arg Asp His Ile Val Arg Phe 
        115                 120                 125             


Leu Asn Met Phe Ile Leu Asp Ser Gly Tyr Thr Ile Gln Glu Cys Lys 
    130                 135                 140                 


Arg Tyr Ser Gln Glu Gly His Gln Gly Ala Lys Leu Val Ser Thr Gly 
145                 150                 155                 160 


Val Trp Ser Arg Gly Asp Lys Ile Glu Arg Leu Ser Gly Val Val Cys 
                165                 170                 175     


Leu Leu Ser Ser Glu Asp Glu Asp Ser Ile Leu Ala Gln Glu Gly Ser 
            180                 185                 190         


Asp Phe Ser Val Met Tyr Ser Thr Arg Lys Arg Cys Ser Thr Leu Trp 
        195                 200                 205             


Leu Gly Pro Gly Ala Tyr Ile Asn His Asp Cys Arg Pro Thr Cys Glu 
    210                 215                 220                 


Phe Val Ser His Gly Ser Thr Ala His Ile Arg Val Leu Arg Asp Met 
225                 230                 235                 240 


Val Pro Gly Asp Glu Ile Thr Cys Phe Tyr Gly Ser Glu Phe Phe Gly 
                245                 250                 255     


Pro Asn Asn Ile Asp Cys Glu Cys Cys Thr Cys Glu Lys Asn Met Asn 
            260                 265                 270         


Gly Ala Phe Ser Tyr Leu Arg Gly Asn Glu Asn Ala Glu Pro Ile Ile 
        275                 280                 285             


Ser Glu Lys Lys Thr Lys Tyr Glu Leu Arg Ser Arg Ser Glu Phe 
    290                 295                 300             


<210>  104
<211>  257
<212>  PRT
<213>  C. elegans

<400>  104

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Lys Val 
1               5                   10                  15      


Ala Ala Lys Lys Leu Ala Thr Ser Arg Met Arg Lys Asp Arg Ala Ala 
            20                  25                  30          


Ala Ala Ser Pro Ser Ser Asp Ile Glu Asn Ser Glu Asn Pro Ser Ser 
        35                  40                  45              


Leu Ala Ser His Ser Ser Ser Ser Gly Arg Met Thr Pro Ser Lys Asn 
    50                  55                  60                  


Thr Arg Ser Arg Lys Gly Val Ser Val Lys Asp Val Ser Asn His Lys 
65                  70                  75                  80  


Ile Thr Glu Phe Phe Gln Val Arg Arg Ser Asn Arg Lys Thr Ser Lys 
                85                  90                  95      


Gln Ile Ser Asp Glu Ala Lys His Ala Leu Arg Asp Thr Val Leu Lys 
            100                 105                 110         


Gly Thr Asn Glu Arg Leu Leu Glu Val Tyr Lys Asp Val Val Lys Gly 
        115                 120                 125             


Arg Gly Ile Arg Thr Lys Val Asn Phe Glu Lys Gly Asp Phe Val Val 
    130                 135                 140                 


Glu Tyr Arg Gly Val Met Met Glu Tyr Ser Glu Ala Lys Val Ile Glu 
145                 150                 155                 160 


Glu Gln Tyr Ser Asn Asp Glu Glu Ile Gly Ser Tyr Met Tyr Phe Phe 
                165                 170                 175     


Glu His Asn Asn Lys Lys Trp Cys Ile Asp Ala Thr Lys Glu Ser Pro 
            180                 185                 190         


Trp Lys Gly Arg Leu Ile Asn His Ser Val Leu Arg Pro Asn Leu Lys 
        195                 200                 205             


Thr Lys Val Val Glu Ile Asp Gly Ser His His Leu Ile Leu Val Ala 
    210                 215                 220                 


Arg Arg Gln Ile Ala Gln Gly Glu Glu Leu Leu Tyr Asp Tyr Gly Asp 
225                 230                 235                 240 


Arg Ser Ala Glu Thr Ile Ala Lys Asn Pro Trp Leu Val Asn Thr Glu 
                245                 250                 255     


Phe 
    


<210>  105
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  105

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ser Cys Asp 
1               5                   10                  15      


Ser Thr Asn Ala Ala Ile Ala Lys Gln Ala Leu Lys Lys Pro Ile Lys 
            20                  25                  30          


Gly Lys Gln Ala Pro Arg Lys Lys Ala Gln Gly Lys Thr Gln Gln Asn 
        35                  40                  45              


Arg Lys Leu Thr Asp Phe Tyr Pro Val Arg Arg Ser Ser Arg Lys Ser 
    50                  55                  60                  


Lys Ala Glu Leu Gln Ser Glu Glu Arg Lys Arg Ile Asp Glu Leu Ile 
65                  70                  75                  80  


Glu Ser Gly Lys Glu Glu Gly Met Lys Ile Asp Leu Ile Asp Gly Lys 
                85                  90                  95      


Gly Arg Gly Val Ile Ala Thr Lys Gln Phe Ser Arg Gly Asp Phe Val 
            100                 105                 110         


Val Glu Tyr His Gly Asp Leu Ile Glu Ile Thr Asp Ala Lys Lys Arg 
        115                 120                 125             


Glu Ala Leu Tyr Ala Gln Asp Pro Ser Thr Gly Cys Tyr Met Tyr Tyr 
    130                 135                 140                 


Phe Gln Tyr Leu Ser Lys Thr Tyr Cys Val Asp Ala Thr Arg Glu Thr 
145                 150                 155                 160 


Asn Arg Leu Gly Arg Leu Ile Asn His Ser Lys Cys Gly Asn Cys Gln 
                165                 170                 175     


Thr Lys Leu His Asp Ile Asp Gly Val Pro His Leu Ile Leu Ile Ala 
            180                 185                 190         


Ser Arg Asp Ile Ala Ala Gly Glu Glu Leu Leu Tyr Asp Tyr Gly Asp 
        195                 200                 205             


Arg Ser Lys Ala Ser Ile Glu Ala Phe Pro Trp Leu Lys His Glu Phe 
    210                 215                 220                 


<210>  106
<211>  319
<212>  PRT
<213>  T. gondii

<400>  106

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ala Ser Arg 
1               5                   10                  15      


Arg Thr Gly Glu Phe Leu Arg Asp Ala Gln Ala Pro Ser Arg Trp Leu 
            20                  25                  30          


Lys Arg Ser Lys Thr Gly Gln Asp Asp Gly Ala Phe Cys Leu Glu Thr 
        35                  40                  45              


Trp Leu Ala Gly Ala Gly Asp Asp Ala Ala Gly Gly Glu Arg Gly Arg 
    50                  55                  60                  


Asp Arg Glu Gly Ala Ala Asp Lys Ala Lys Gln Arg Glu Glu Arg Arg 
65                  70                  75                  80  


Gln Lys Glu Leu Glu Glu Arg Phe Glu Glu Met Lys Val Glu Phe Glu 
                85                  90                  95      


Glu Lys Ala Gln Arg Met Ile Ala Arg Arg Ala Ala Leu Thr Gly Glu 
            100                 105                 110         


Ile Tyr Ser Asp Gly Lys Gly Ser Lys Lys Pro Arg Val Pro Ser Leu 
        115                 120                 125             


Pro Glu Asn Asp Asp Asp Ala Leu Ile Glu Ile Ile Ile Asp Pro Glu 
    130                 135                 140                 


Gln Gly Ile Leu Lys Trp Pro Leu Ser Val Met Ser Ile Arg Gln Arg 
145                 150                 155                 160 


Thr Val Ile Tyr Gln Glu Cys Leu Arg Arg Asp Leu Thr Ala Cys Ile 
                165                 170                 175     


His Leu Thr Lys Val Pro Gly Lys Gly Arg Ala Val Phe Ala Ala Asp 
            180                 185                 190         


Thr Ile Leu Lys Asp Asp Phe Val Val Glu Tyr Lys Gly Glu Leu Cys 
        195                 200                 205             


Ser Glu Arg Glu Ala Arg Glu Arg Glu Gln Arg Tyr Asn Arg Ser Lys 
    210                 215                 220                 


Val Pro Met Gly Ser Phe Met Phe Tyr Phe Lys Asn Gly Ser Arg Met 
225                 230                 235                 240 


Met Ala Ile Asp Ala Thr Asp Glu Lys Gln Asp Phe Gly Pro Ala Arg 
                245                 250                 255     


Leu Ile Asn His Ser Arg Arg Asn Pro Asn Met Thr Pro Arg Ala Ile 
            260                 265                 270         


Thr Leu Gly Asp Phe Asn Ser Glu Pro Arg Leu Ile Phe Val Ala Arg 
        275                 280                 285             


Arg Asn Ile Glu Lys Gly Glu Glu Leu Leu Val Asp Tyr Gly Glu Arg 
    290                 295                 300                 


Asp Pro Asp Val Ile Lys Glu His Pro Trp Leu Asn Ser Glu Phe 
305                 310                 315                 


<210>  107
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  107
gagtccgagc agaagaagaa ggg                                               23


<210>  108
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  108
gaggccgagc agaagaaaga cgg                                               23


<210>  109
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  109
gagtcctagc aggagaagaa gag                                               23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  110
gagtctaagc agaagaagaa gag                                               23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  111
gagttagagc agaagaagaa agg                                               23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  112
gggtgggggg agtttgctcc tgg                                               23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  113
ggatggaggg agtttgctcc tgg                                               23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  114
gggagggtgg agtttgctcc tgg                                               23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  115
cgggggaggg agtttgctcc tgg                                               23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  116
ggggagggga agtttgctcc tgg                                               23


<210>  117
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  117
gcagatgtag tgtttccaca ggg                                               23


<210>  118
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  118
acatatgtag tatttccaca ggg                                               23


<210>  119
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  119
ccagatgtag tattcccaca ggg                                               23


<210>  120
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  120
ctagatgaag tgcttccaca tgg                                               23


<210>  121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  121
agctggagga ggaagggcct                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  122
ccccttcttc tgcaaatgag                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  123
ggctggggcc agcatgacct                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  124
cctttattca tagtagacaa                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  125
catggcaaga cagattgtca                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  126
gggaatgggc tttggaaagg                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  127
catctaagga cggatttgtg                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  128
ctggtcagcc cattatgata                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  129
ctggagagag gctcccatca                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  130
catttttgct gtcacaactc                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  131
ctgagtagga ttaagatatt                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  132
gttgggaaga gatgcataca                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  133
gcctccttga ttgaggtgtc                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  134
ctcatctaga gttctttcca                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  135
ctcccatcac atcaaccggt                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  136
cgacagatgt tggggggagg                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  137
gcagcctaga gtcttctgtg                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  138
agccactacc caaccatcta                                                   20


<210>  139
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  139
catggagtaa aggcaatctt                                                   20


<210>  140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  140
accccctatt tctgacctcc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  141
ggtgtcagaa tgtcctgtct                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  142
ggatggaagg gccggctccg                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  143
ggaacctgtg atccccacag                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  144
cattcagtgg gtagagtcca                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  145
tggctcttca gtgcaccagc                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  146
aatacaatgg acaaataacc                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  147
gtctggcagg cccctcctgt                                                   20


<210>  148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  148
ctttcattag agtttagtcc                                                   20


<210>  149
<211>  1239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  149
tgccttgccg agggtacccg aatcttcgat ccggtcactg gtacaacgca tcgcatcgag       60

gatgttgtcg atgggcgcaa gcctattcat gtcgtggctg ctgccaagga cggaacgctg      120

ctcgcgcggc ccgtggtgtc ctggttcgac cagggaacgc gggatgtgat cgggttgcgg      180

atcgccggtg gcgccatcgt gtgggcgaca cccgatcaca aggtgctgac agagtacggc      240

tggcgtgccg ccggggaact ccgcaaggga gacagggtgg ccggaccggg tggttctggt      300

aacagcctgg ccttgtccct gacggccgac cagatggtca gtgccttgtt ggatgctgag      360

ccccccatac tctattccga gtatgatcct accagtccct tcagtgaagc ttcgatgatg      420

ggcttactga ccaacctggc agacagggag ctggttcaca tgatcaactg ggcgaagagg      480

gtgccaggct ttgtggattt gaccctccat gatcaggccc accttctaga acgtgcctgg      540

ctagagatcc tgatgattgg tctcgtctgg cgctccatgg agcacccagg gaagctactg      600

tttgctccta acttgctctt ggacaggaac cagggaaaat gtgtagaggg catggtggag      660

atcttcgaca tgctgctggc tacatcatct cggttccgca tgatgaatct gcagggagag      720

gagtttgtgt gcctcaaatc tattattttg cttaattctg gagtgtacac atttctgtcc      780

agcaccctga agtctctgga agagaaggac catatccacc gagccctgga caagatcacg      840

gacactttga tccacctgat ggccaaggca ggcctgaccc tgcagcagca gcaccagcgg      900

ctggcccagc tcctcctcat cctctcccac atcaggcaca tgagtaacaa aggaatggag      960

catctgtaca gcatgaagta caagaacgtg gtgcccctct atgacctgct gctggagatg     1020

ctggacgccc accgcctaca tgcgggtggt tctggtgcta gccgcgtgca ggcgttcgcg     1080

gatgccctgg atgacaaatt cctgcacgac atgctggcgg aaggactccg ctattccgtg     1140

atccgagaag tgctgccaac gcggcgggca cgaacgttcg acctcgaggt cgaggaactg     1200

cacaccctcg tcgccgaagg ggttgtcgtg cacaactgc                            1239 


<210>  150
<211>  1404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  150

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Ser Asp  Tyr Lys Asp 
    1370                 1375                 1380             


His Asp  Gly Asp Tyr Lys Asp  His Asp Ile Asp Tyr  Lys Asp Asp 
    1385                 1390                 1395             


Asp Asp  Lys Ala Ala Gly 
    1400                 


<210>  151
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  151

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His 
                85                  90                  95      


Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala 
            100                 105                 110         


Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe 
        115                 120                 125             


Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala 
    130                 135                 140                 


Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp 
145                 150                 155                 160 


Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly 
                165                 170                 175     


Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val 
            180                 185                 190         


Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp 
        195                 200                 205             


Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn 
    210                 215                 220                 


Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val 
225                 230                 235                 240 


Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu 
                245                 250                 255     


Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met 
            260                 265                 270         


Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg 
        275                 280                 285             


Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu 
    290                 295                 300                 


Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu 
305                 310                 315                 320 


Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr 
                325                 330                 335     


Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His 
            340                 345                 350         


Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys 
        355                 360                 365             


Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu 
    370                 375                 380                 


Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His 
385                 390                 395                 400 


Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu 
                405                 410                 415     


Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala 
            420                 425                 430         


Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His 
        435                 440                 445             


Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu 
    450                 455                 460                 


Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His 
465                 470                 475                 480 


Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys Tyr Leu Gln Glu 
                485                 490                 495     


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            500                 505                 510         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        515                 520                 525             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    530                 535                 540                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
545                 550                 555                 560 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                565                 570                 575     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            580                 585                 590         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        595                 600                 605             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    610                 615                 620                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  152
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  152

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Cys Leu 
        115                 120                 125             


Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg 
    130                 135                 140                 


Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala 
145                 150                 155                 160 


Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp 
                165                 170                 175     


Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile 
            180                 185                 190         


Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg 
        195                 200                 205             


Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly 
    210                 215                 220                 


Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
225                 230                 235                 240 


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
                245                 250                 255     


Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
            260                 265                 270         


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
        275                 280                 285             


Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg 
    290                 295                 300                 


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
305                 310                 315                 320 


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
                325                 330                 335     


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
            340                 345                 350         


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
        355                 360                 365             


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
    370                 375                 380                 


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
385                 390                 395                 400 


Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
                405                 410                 415     


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
            420                 425                 430         


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
        435                 440                 445             


Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu 
    450                 455                 460                 


Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser 
465                 470                 475                 480 


Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp 
                485                 490                 495     


Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro 
            500                 505                 510         


Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr 
        515                 520                 525             


Leu Val Ala Glu Gly Val Val Val His Asn Cys Tyr His Glu Lys Tyr 
    530                 535                 540                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
545                 550                 555                 560 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                565                 570                 575     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            580                 585                 590         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        595                 600                 605             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    610                 615                 620                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  153
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  153

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr 
145                 150                 155                 160 


Thr His Arg Ile Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val 
                165                 170                 175     


Val Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser 
            180                 185                 190         


Trp Phe Asp Gln Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly 
        195                 200                 205             


Gly Ala Ile Val Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr 
    210                 215                 220                 


Gly Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly 
225                 230                 235                 240 


Pro Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
                245                 250                 255     


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
            260                 265                 270         


Tyr Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
        275                 280                 285             


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
    290                 295                 300                 


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu 
305                 310                 315                 320 


Leu Glu Arg Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
                325                 330                 335     


Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
            340                 345                 350         


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
        355                 360                 365             


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
    370                 375                 380                 


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
385                 390                 395                 400 


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
                405                 410                 415     


Ile His Arg Ala Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
            420                 425                 430         


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
        435                 440                 445             


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
    450                 455                 460                 


Glu His Leu Tyr Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp 
465                 470                 475                 480 


Leu Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser 
                485                 490                 495     


Gly Ala Ser Arg Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe 
            500                 505                 510         


Leu His Asp Met Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu 
        515                 520                 525             


Val Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu 
    530                 535                 540                 


Leu His Thr Leu Val Ala Glu Gly Val Val Val His Asn Cys Asp Lys 
545                 550                 555                 560 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                565                 570                 575     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            580                 585                 590         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        595                 600                 605             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    610                 615                 620                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  154
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  154

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Cys Leu Ala Glu Gly Thr 
    210                 215                 220                 


Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val 
225                 230                 235                 240 


Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly 
                245                 250                 255     


Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg 
            260                 265                 270         


Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr 
        275                 280                 285             


Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu 
    290                 295                 300                 


Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser 
305                 310                 315                 320 


Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp 
                325                 330                 335     


Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe 
            340                 345                 350         


Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu 
        355                 360                 365             


Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp 
    370                 375                 380                 


Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu 
385                 390                 395                 400 


Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys 
                405                 410                 415     


Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys 
            420                 425                 430         


Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser 
        435                 440                 445             


Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys 
    450                 455                 460                 


Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr 
465                 470                 475                 480 


Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu Asp Lys 
                485                 490                 495     


Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu 
            500                 505                 510         


Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His 
        515                 520                 525             


Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys 
    530                 535                 540                 


Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp 
545                 550                 555                 560 


Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg Val Gln Ala 
                565                 570                 575     


Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met Leu Ala Glu 
            580                 585                 590         


Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr Arg Arg Ala 
        595                 600                 605             


Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu Val Ala Glu 
    610                 615                 620                 


Gly Val Val Val His Asn Cys Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  155
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  155

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Cys Leu Ala Glu 
                325                 330                 335     


Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu 
            340                 345                 350         


Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys 
        355                 360                 365             


Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly 
    370                 375                 380                 


Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp 
385                 390                 395                 400 


Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala 
                405                 410                 415     


Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly 
            420                 425                 430         


Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu 
        435                 440                 445             


Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser 
    450                 455                 460                 


Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp 
465                 470                 475                 480 


Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe 
                485                 490                 495     


Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp 
            500                 505                 510         


Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro 
        515                 520                 525             


Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly 
    530                 535                 540                 


Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr 
545                 550                 555                 560 


Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys 
                565                 570                 575     


Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser 
            580                 585                 590         


Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu 
        595                 600                 605             


Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu 
    610                 615                 620                 


Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu 
625                 630                 635                 640 


Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser 
                645                 650                 655     


Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met 
            660                 665                 670         


Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg Val 
        675                 680                 685             


Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met Leu 
    690                 695                 700                 


Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr Arg 
705                 710                 715                 720 


Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu Val 
                725                 730                 735     


Ala Glu Gly Val Val Val His Asn Cys Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  156
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  156

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Cys Leu Ala Glu Gly Thr Arg Ile Phe Asp 
        515                 520                 525             


Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val Val Asp Gly Arg 
    530                 535                 540                 


Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly Thr Leu Leu Ala 
545                 550                 555                 560 


Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg Asp Val Ile Gly 
                565                 570                 575     


Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr Pro Asp His Lys 
            580                 585                 590         


Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu Leu Arg Lys Gly 
        595                 600                 605             


Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser Leu Ala Leu Ser 
    610                 615                 620                 


Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
625                 630                 635                 640 


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe Ser Glu Ala Ser 
                645                 650                 655     


Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
            660                 665                 670         


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
        675                 680                 685             


Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu Ile Leu Met Ile 
    690                 695                 700                 


Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala 
705                 710                 715                 720 


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
                725                 730                 735     


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
            740                 745                 750         


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
        755                 760                 765             


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
    770                 775                 780                 


Glu Glu Lys Asp His Ile His Arg Ala Leu Asp Lys Ile Thr Asp Thr 
785                 790                 795                 800 


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
                805                 810                 815     


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
            820                 825                 830         


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Tyr Lys Asn Val 
        835                 840                 845             


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His Arg Leu 
    850                 855                 860                 


His Ala Gly Gly Ser Gly Ala Ser Arg Val Gln Ala Phe Ala Asp Ala 
865                 870                 875                 880 


Leu Asp Asp Lys Phe Leu His Asp Met Leu Ala Glu Gly Leu Arg Tyr 
                885                 890                 895     


Ser Val Ile Arg Glu Val Leu Pro Thr Arg Arg Ala Arg Thr Phe Asp 
            900                 905                 910         


Leu Glu Val Glu Glu Leu His Thr Leu Val Ala Glu Gly Val Val Val 
        915                 920                 925             


His Asn Cys Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  157
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  157

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Leu Ala 
                565                 570                 575     


Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile 
            580                 585                 590         


Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala 
        595                 600                 605             


Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln 
    610                 615                 620                 


Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val 
625                 630                 635                 640 


Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala 
                645                 650                 655     


Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser 
            660                 665                 670         


Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala 
        675                 680                 685             


Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr 
    690                 695                 700                 


Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala 
705                 710                 715                 720 


Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly 
                725                 730                 735     


Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala 
            740                 745                 750         


Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His 
        755                 760                 765             


Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln 
    770                 775                 780                 


Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala 
785                 790                 795                 800 


Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val 
                805                 810                 815     


Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu 
            820                 825                 830         


Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala 
        835                 840                 845             


Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly 
    850                 855                 860                 


Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile 
865                 870                 875                 880 


Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr 
                885                 890                 895     


Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu 
            900                 905                 910         


Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg 
        915                 920                 925             


Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met 
    930                 935                 940                 


Leu Ala Glu Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr 
945                 950                 955                 960 


Arg Arg Ala Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu 
                965                 970                 975     


Val Ala Glu Gly Val Val Val His Asn Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  158
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  158

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Cys Leu Ala 
    610                 615                 620                 


Glu Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile 
625                 630                 635                 640 


Glu Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala 
                645                 650                 655     


Lys Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln 
            660                 665                 670         


Gly Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val 
        675                 680                 685             


Trp Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala 
    690                 695                 700                 


Ala Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser 
705                 710                 715                 720 


Gly Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala 
                725                 730                 735     


Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr 
            740                 745                 750         


Ser Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala 
        755                 760                 765             


Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly 
    770                 775                 780                 


Phe Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala 
785                 790                 795                 800 


Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His 
                805                 810                 815     


Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln 
            820                 825                 830         


Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala 
        835                 840                 845             


Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val 
    850                 855                 860                 


Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu 
865                 870                 875                 880 


Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala 
                885                 890                 895     


Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly 
            900                 905                 910         


Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile 
        915                 920                 925             


Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr 
    930                 935                 940                 


Ser Met Lys Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu 
945                 950                 955                 960 


Met Leu Asp Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg 
                965                 970                 975     


Val Gln Ala Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met 
            980                 985                 990         


Leu Ala Glu Gly Leu Arg Tyr Ser  Val Ile Arg Glu Val  Leu Pro Thr 
        995                 1000                 1005             


Arg Arg  Ala Arg Thr Phe Asp  Leu Glu Val Glu Glu  Leu His Thr 
    1010                 1015                 1020             


Leu Val  Ala Glu Gly Val Val  Val His Asn Cys Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  159
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  159

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Cys Leu Ala Glu 
    690                 695                 700                 


Gly Thr Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu 
705                 710                 715                 720 


Asp Val Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys 
                725                 730                 735     


Asp Gly Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly 
            740                 745                 750         


Thr Arg Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp 
        755                 760                 765             


Ala Thr Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala 
    770                 775                 780                 


Gly Glu Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly 
785                 790                 795                 800 


Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu 
                805                 810                 815     


Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser 
            820                 825                 830         


Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp 
        835                 840                 845             


Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe 
    850                 855                 860                 


Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp 
865                 870                 875                 880 


Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro 
                885                 890                 895     


Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly 
            900                 905                 910         


Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr 
        915                 920                 925             


Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys 
    930                 935                 940                 


Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser 
945                 950                 955                 960 


Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu 
                965                 970                 975     


Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu 
            980                 985                 990         


Thr Leu Gln Gln Gln His Gln Arg  Leu Ala Gln Leu Leu  Leu Ile Leu 
        995                 1000                 1005             


Ser His  Ile Arg His Met Ser  Asn Lys Gly Met Glu  His Leu Tyr 
    1010                 1015                 1020             


Ser Met  Lys Tyr Lys Asn Val  Val Pro Leu Tyr Asp  Leu Leu Leu 
    1025                 1030                 1035             


Glu Met  Leu Asp Ala His Arg  Leu His Ala Gly Gly  Ser Gly Ala 
    1040                 1045                 1050             


Ser Arg  Val Gln Ala Phe Ala  Asp Ala Leu Asp Asp  Lys Phe Leu 
    1055                 1060                 1065             


His Asp  Met Leu Ala Glu Gly  Leu Arg Tyr Ser Val  Ile Arg Glu 
    1070                 1075                 1080             


Val Leu  Pro Thr Arg Arg Ala  Arg Thr Phe Asp Leu  Glu Val Glu 
    1085                 1090                 1095             


Glu Leu  His Thr Leu Val Ala  Glu Gly Val Val Val  His Asn Cys 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  160
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  160

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Cys Leu Ala Glu Gly Thr Arg Ile Phe 
                725                 730                 735     


Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val Val Asp Gly 
            740                 745                 750         


Arg Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly Thr Leu Leu 
        755                 760                 765             


Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg Asp Val Ile 
    770                 775                 780                 


Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr Pro Asp His 
785                 790                 795                 800 


Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu Leu Arg Lys 
                805                 810                 815     


Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser Leu Ala Leu 
            820                 825                 830         


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
        835                 840                 845             


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe Ser Glu Ala 
    850                 855                 860                 


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
865                 870                 875                 880 


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
                885                 890                 895     


His Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu Ile Leu Met 
            900                 905                 910         


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe 
        915                 920                 925             


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
    930                 935                 940                 


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
945                 950                 955                 960 


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
                965                 970                 975     


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
            980                 985                 990         


Leu Glu Glu Lys Asp His Ile His  Arg Ala Leu Asp Lys  Ile Thr Asp 
        995                 1000                 1005             


Thr Leu  Ile His Leu Met Ala  Lys Ala Gly Leu Thr  Leu Gln Gln 
    1010                 1015                 1020             


Gln His  Gln Arg Leu Ala Gln  Leu Leu Leu Ile Leu  Ser His Ile 
    1025                 1030                 1035             


Arg His  Met Ser Asn Lys Gly  Met Glu His Leu Tyr  Ser Met Lys 
    1040                 1045                 1050             


Tyr Lys  Asn Val Val Pro Leu  Tyr Asp Leu Leu Leu  Glu Met Leu 
    1055                 1060                 1065             


Asp Ala  His Arg Leu His Ala  Gly Gly Ser Gly Ala  Ser Arg Val 
    1070                 1075                 1080             


Gln Ala  Phe Ala Asp Ala Leu  Asp Asp Lys Phe Leu  His Asp Met 
    1085                 1090                 1095             


Leu Ala  Glu Gly Leu Arg Tyr  Ser Val Ile Arg Glu  Val Leu Pro 
    1100                 1105                 1110             


Thr Arg  Arg Ala Arg Thr Phe  Asp Leu Glu Val Glu  Glu Leu His 
    1115                 1120                 1125             


Thr Leu  Val Ala Glu Gly Val  Val Val His Asn Cys  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  161
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  161

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Cys Leu Ala Glu Gly Thr  Arg Ile Phe Asp Pro  Val Thr Gly 
        995                 1000                 1005             


Thr Thr  His Arg Ile Glu Asp  Val Val Asp Gly Arg  Lys Pro Ile 
    1010                 1015                 1020             


His Val  Val Ala Ala Ala Lys  Asp Gly Thr Leu Leu  Ala Arg Pro 
    1025                 1030                 1035             


Val Val  Ser Trp Phe Asp Gln  Gly Thr Arg Asp Val  Ile Gly Leu 
    1040                 1045                 1050             


Arg Ile  Ala Gly Gly Ala Ile  Val Trp Ala Thr Pro  Asp His Lys 
    1055                 1060                 1065             


Val Leu  Thr Glu Tyr Gly Trp  Arg Ala Ala Gly Glu  Leu Arg Lys 
    1070                 1075                 1080             


Gly Asp  Arg Val Ala Gly Pro  Gly Gly Ser Gly Asn  Ser Leu Ala 
    1085                 1090                 1095             


Leu Ser  Leu Thr Ala Asp Gln  Met Val Ser Ala Leu  Leu Asp Ala 
    1100                 1105                 1110             


Glu Pro  Pro Ile Leu Tyr Ser  Glu Tyr Asp Pro Thr  Ser Pro Phe 
    1115                 1120                 1125             


Ser Glu  Ala Ser Met Met Gly  Leu Leu Thr Asn Leu  Ala Asp Arg 
    1130                 1135                 1140             


Glu Leu  Val His Met Ile Asn  Trp Ala Lys Arg Val  Pro Gly Phe 
    1145                 1150                 1155             


Val Asp  Leu Thr Leu His Asp  Gln Ala His Leu Leu  Glu Arg Ala 
    1160                 1165                 1170             


Trp Leu  Glu Ile Leu Met Ile  Gly Leu Val Trp Arg  Ser Met Glu 
    1175                 1180                 1185             


His Pro  Gly Lys Leu Leu Phe  Ala Pro Asn Leu Leu  Leu Asp Arg 
    1190                 1195                 1200             


Asn Gln  Gly Lys Cys Val Glu  Gly Met Val Glu Ile  Phe Asp Met 
    1205                 1210                 1215             


Leu Leu  Ala Thr Ser Ser Arg  Phe Arg Met Met Asn  Leu Gln Gly 
    1220                 1225                 1230             


Glu Glu  Phe Val Cys Leu Lys  Ser Ile Ile Leu Leu  Asn Ser Gly 
    1235                 1240                 1245             


Val Tyr  Thr Phe Leu Ser Ser  Thr Leu Lys Ser Leu  Glu Glu Lys 
    1250                 1255                 1260             


Asp His  Ile His Arg Ala Leu  Asp Lys Ile Thr Asp  Thr Leu Ile 
    1265                 1270                 1275             


His Leu  Met Ala Lys Ala Gly  Leu Thr Leu Gln Gln  Gln His Gln 
    1280                 1285                 1290             


Arg Leu  Ala Gln Leu Leu Leu  Ile Leu Ser His Ile  Arg His Met 
    1295                 1300                 1305             


Ser Asn  Lys Gly Met Glu His  Leu Tyr Ser Met Lys  Tyr Lys Asn 
    1310                 1315                 1320             


Val Val  Pro Leu Tyr Asp Leu  Leu Leu Glu Met Leu  Asp Ala His 
    1325                 1330                 1335             


Arg Leu  His Ala Gly Gly Ser  Gly Ala Ser Arg Val  Gln Ala Phe 
    1340                 1345                 1350             


Ala Asp  Ala Leu Asp Asp Lys  Phe Leu His Asp Met  Leu Ala Glu 
    1355                 1360                 1365             


Gly Leu  Arg Tyr Ser Val Ile  Arg Glu Val Leu Pro  Thr Arg Arg 
    1370                 1375                 1380             


Ala Arg  Thr Phe Asp Leu Glu  Val Glu Glu Leu His  Thr Leu Val 
    1385                 1390                 1395             


Ala Glu  Gly Val Val Val His  Asn Cys Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  162
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  162

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Cys Leu Ala 
        995                 1000                 1005             


Glu Gly  Thr Arg Ile Phe Asp  Pro Val Thr Gly Thr  Thr His Arg 
    1010                 1015                 1020             


Ile Glu  Asp Val Val Asp Gly  Arg Lys Pro Ile His  Val Val Ala 
    1025                 1030                 1035             


Ala Ala  Lys Asp Gly Thr Leu  Leu Ala Arg Pro Val  Val Ser Trp 
    1040                 1045                 1050             


Phe Asp  Gln Gly Thr Arg Asp  Val Ile Gly Leu Arg  Ile Ala Gly 
    1055                 1060                 1065             


Gly Ala  Ile Val Trp Ala Thr  Pro Asp His Lys Val  Leu Thr Glu 
    1070                 1075                 1080             


Tyr Gly  Trp Arg Ala Ala Gly  Glu Leu Arg Lys Gly  Asp Arg Val 
    1085                 1090                 1095             


Ala Gly  Pro Gly Gly Ser Gly  Asn Ser Leu Ala Leu  Ser Leu Thr 
    1100                 1105                 1110             


Ala Asp  Gln Met Val Ser Ala  Leu Leu Asp Ala Glu  Pro Pro Ile 
    1115                 1120                 1125             


Leu Tyr  Ser Glu Tyr Asp Pro  Thr Ser Pro Phe Ser  Glu Ala Ser 
    1130                 1135                 1140             


Met Met  Gly Leu Leu Thr Asn  Leu Ala Asp Arg Glu  Leu Val His 
    1145                 1150                 1155             


Met Ile  Asn Trp Ala Lys Arg  Val Pro Gly Phe Val  Asp Leu Thr 
    1160                 1165                 1170             


Leu His  Asp Gln Ala His Leu  Leu Glu Arg Ala Trp  Leu Glu Ile 
    1175                 1180                 1185             


Leu Met  Ile Gly Leu Val Trp  Arg Ser Met Glu His  Pro Gly Lys 
    1190                 1195                 1200             


Leu Leu  Phe Ala Pro Asn Leu  Leu Leu Asp Arg Asn  Gln Gly Lys 
    1205                 1210                 1215             


Cys Val  Glu Gly Met Val Glu  Ile Phe Asp Met Leu  Leu Ala Thr 
    1220                 1225                 1230             


Ser Ser  Arg Phe Arg Met Met  Asn Leu Gln Gly Glu  Glu Phe Val 
    1235                 1240                 1245             


Cys Leu  Lys Ser Ile Ile Leu  Leu Asn Ser Gly Val  Tyr Thr Phe 
    1250                 1255                 1260             


Leu Ser  Ser Thr Leu Lys Ser  Leu Glu Glu Lys Asp  His Ile His 
    1265                 1270                 1275             


Arg Ala  Leu Asp Lys Ile Thr  Asp Thr Leu Ile His  Leu Met Ala 
    1280                 1285                 1290             


Lys Ala  Gly Leu Thr Leu Gln  Gln Gln His Gln Arg  Leu Ala Gln 
    1295                 1300                 1305             


Leu Leu  Leu Ile Leu Ser His  Ile Arg His Met Ser  Asn Lys Gly 
    1310                 1315                 1320             


Met Glu  His Leu Tyr Ser Met  Lys Tyr Lys Asn Val  Val Pro Leu 
    1325                 1330                 1335             


Tyr Asp  Leu Leu Leu Glu Met  Leu Asp Ala His Arg  Leu His Ala 
    1340                 1345                 1350             


Gly Gly  Ser Gly Ala Ser Arg  Val Gln Ala Phe Ala  Asp Ala Leu 
    1355                 1360                 1365             


Asp Asp  Lys Phe Leu His Asp  Met Leu Ala Glu Gly  Leu Arg Tyr 
    1370                 1375                 1380             


Ser Val  Ile Arg Glu Val Leu  Pro Thr Arg Arg Ala  Arg Thr Phe 
    1385                 1390                 1395             


Asp Leu  Glu Val Glu Glu Leu  His Thr Leu Val Ala  Glu Gly Val 
    1400                 1405                 1410             


Val Val  His Asn Cys Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  163
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  163

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Cys Leu  Ala Glu Gly 
    1145                 1150                 1155             


Thr Arg  Ile Phe Asp Pro Val  Thr Gly Thr Thr His  Arg Ile Glu 
    1160                 1165                 1170             


Asp Val  Val Asp Gly Arg Lys  Pro Ile His Val Val  Ala Ala Ala 
    1175                 1180                 1185             


Lys Asp  Gly Thr Leu Leu Ala  Arg Pro Val Val Ser  Trp Phe Asp 
    1190                 1195                 1200             


Gln Gly  Thr Arg Asp Val Ile  Gly Leu Arg Ile Ala  Gly Gly Ala 
    1205                 1210                 1215             


Ile Val  Trp Ala Thr Pro Asp  His Lys Val Leu Thr  Glu Tyr Gly 
    1220                 1225                 1230             


Trp Arg  Ala Ala Gly Glu Leu  Arg Lys Gly Asp Arg  Val Ala Gly 
    1235                 1240                 1245             


Pro Gly  Gly Ser Gly Asn Ser  Leu Ala Leu Ser Leu  Thr Ala Asp 
    1250                 1255                 1260             


Gln Met  Val Ser Ala Leu Leu  Asp Ala Glu Pro Pro  Ile Leu Tyr 
    1265                 1270                 1275             


Ser Glu  Tyr Asp Pro Thr Ser  Pro Phe Ser Glu Ala  Ser Met Met 
    1280                 1285                 1290             


Gly Leu  Leu Thr Asn Leu Ala  Asp Arg Glu Leu Val  His Met Ile 
    1295                 1300                 1305             


Asn Trp  Ala Lys Arg Val Pro  Gly Phe Val Asp Leu  Thr Leu His 
    1310                 1315                 1320             


Asp Gln  Ala His Leu Leu Glu  Arg Ala Trp Leu Glu  Ile Leu Met 
    1325                 1330                 1335             


Ile Gly  Leu Val Trp Arg Ser  Met Glu His Pro Gly  Lys Leu Leu 
    1340                 1345                 1350             


Phe Ala  Pro Asn Leu Leu Leu  Asp Arg Asn Gln Gly  Lys Cys Val 
    1355                 1360                 1365             


Glu Gly  Met Val Glu Ile Phe  Asp Met Leu Leu Ala  Thr Ser Ser 
    1370                 1375                 1380             


Arg Phe  Arg Met Met Asn Leu  Gln Gly Glu Glu Phe  Val Cys Leu 
    1385                 1390                 1395             


Lys Ser  Ile Ile Leu Leu Asn  Ser Gly Val Tyr Thr  Phe Leu Ser 
    1400                 1405                 1410             


Ser Thr  Leu Lys Ser Leu Glu  Glu Lys Asp His Ile  His Arg Ala 
    1415                 1420                 1425             


Leu Asp  Lys Ile Thr Asp Thr  Leu Ile His Leu Met  Ala Lys Ala 
    1430                 1435                 1440             


Gly Leu  Thr Leu Gln Gln Gln  His Gln Arg Leu Ala  Gln Leu Leu 
    1445                 1450                 1455             


Leu Ile  Leu Ser His Ile Arg  His Met Ser Asn Lys  Gly Met Glu 
    1460                 1465                 1470             


His Leu  Tyr Ser Met Lys Tyr  Lys Asn Val Val Pro  Leu Tyr Asp 
    1475                 1480                 1485             


Leu Leu  Leu Glu Met Leu Asp  Ala His Arg Leu His  Ala Gly Gly 
    1490                 1495                 1500             


Ser Gly  Ala Ser Arg Val Gln  Ala Phe Ala Asp Ala  Leu Asp Asp 
    1505                 1510                 1515             


Lys Phe  Leu His Asp Met Leu  Ala Glu Gly Leu Arg  Tyr Ser Val 
    1520                 1525                 1530             


Ile Arg  Glu Val Leu Pro Thr  Arg Arg Ala Arg Thr  Phe Asp Leu 
    1535                 1540                 1545             


Glu Val  Glu Glu Leu His Thr  Leu Val Ala Glu Gly  Val Val Val 
    1550                 1555                 1560             


His Asn  Cys Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  164
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  164

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Cys Leu  Ala Glu Gly Thr Arg  Ile Phe Asp Pro Val  Thr Gly Thr 
    1160                 1165                 1170             


Thr His  Arg Ile Glu Asp Val  Val Asp Gly Arg Lys  Pro Ile His 
    1175                 1180                 1185             


Val Val  Ala Ala Ala Lys Asp  Gly Thr Leu Leu Ala  Arg Pro Val 
    1190                 1195                 1200             


Val Ser  Trp Phe Asp Gln Gly  Thr Arg Asp Val Ile  Gly Leu Arg 
    1205                 1210                 1215             


Ile Ala  Gly Gly Ala Ile Val  Trp Ala Thr Pro Asp  His Lys Val 
    1220                 1225                 1230             


Leu Thr  Glu Tyr Gly Trp Arg  Ala Ala Gly Glu Leu  Arg Lys Gly 
    1235                 1240                 1245             


Asp Arg  Val Ala Gly Pro Gly  Gly Ser Gly Asn Ser  Leu Ala Leu 
    1250                 1255                 1260             


Ser Leu  Thr Ala Asp Gln Met  Val Ser Ala Leu Leu  Asp Ala Glu 
    1265                 1270                 1275             


Pro Pro  Ile Leu Tyr Ser Glu  Tyr Asp Pro Thr Ser  Pro Phe Ser 
    1280                 1285                 1290             


Glu Ala  Ser Met Met Gly Leu  Leu Thr Asn Leu Ala  Asp Arg Glu 
    1295                 1300                 1305             


Leu Val  His Met Ile Asn Trp  Ala Lys Arg Val Pro  Gly Phe Val 
    1310                 1315                 1320             


Asp Leu  Thr Leu His Asp Gln  Ala His Leu Leu Glu  Arg Ala Trp 
    1325                 1330                 1335             


Leu Glu  Ile Leu Met Ile Gly  Leu Val Trp Arg Ser  Met Glu His 
    1340                 1345                 1350             


Pro Gly  Lys Leu Leu Phe Ala  Pro Asn Leu Leu Leu  Asp Arg Asn 
    1355                 1360                 1365             


Gln Gly  Lys Cys Val Glu Gly  Met Val Glu Ile Phe  Asp Met Leu 
    1370                 1375                 1380             


Leu Ala  Thr Ser Ser Arg Phe  Arg Met Met Asn Leu  Gln Gly Glu 
    1385                 1390                 1395             


Glu Phe  Val Cys Leu Lys Ser  Ile Ile Leu Leu Asn  Ser Gly Val 
    1400                 1405                 1410             


Tyr Thr  Phe Leu Ser Ser Thr  Leu Lys Ser Leu Glu  Glu Lys Asp 
    1415                 1420                 1425             


His Ile  His Arg Ala Leu Asp  Lys Ile Thr Asp Thr  Leu Ile His 
    1430                 1435                 1440             


Leu Met  Ala Lys Ala Gly Leu  Thr Leu Gln Gln Gln  His Gln Arg 
    1445                 1450                 1455             


Leu Ala  Gln Leu Leu Leu Ile  Leu Ser His Ile Arg  His Met Ser 
    1460                 1465                 1470             


Asn Lys  Gly Met Glu His Leu  Tyr Ser Met Lys Tyr  Lys Asn Val 
    1475                 1480                 1485             


Val Pro  Leu Tyr Asp Leu Leu  Leu Glu Met Leu Asp  Ala His Arg 
    1490                 1495                 1500             


Leu His  Ala Gly Gly Ser Gly  Ala Ser Arg Val Gln  Ala Phe Ala 
    1505                 1510                 1515             


Asp Ala  Leu Asp Asp Lys Phe  Leu His Asp Met Leu  Ala Glu Gly 
    1520                 1525                 1530             


Leu Arg  Tyr Ser Val Ile Arg  Glu Val Leu Pro Thr  Arg Arg Ala 
    1535                 1540                 1545             


Arg Thr  Phe Asp Leu Glu Val  Glu Glu Leu His Thr  Leu Val Ala 
    1550                 1555                 1560             


Glu Gly  Val Val Val His Asn  Cys Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  165
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  165

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Cys Leu  Ala Glu Gly 
    1265                 1270                 1275             


Thr Arg  Ile Phe Asp Pro Val  Thr Gly Thr Thr His  Arg Ile Glu 
    1280                 1285                 1290             


Asp Val  Val Asp Gly Arg Lys  Pro Ile His Val Val  Ala Ala Ala 
    1295                 1300                 1305             


Lys Asp  Gly Thr Leu Leu Ala  Arg Pro Val Val Ser  Trp Phe Asp 
    1310                 1315                 1320             


Gln Gly  Thr Arg Asp Val Ile  Gly Leu Arg Ile Ala  Gly Gly Ala 
    1325                 1330                 1335             


Ile Val  Trp Ala Thr Pro Asp  His Lys Val Leu Thr  Glu Tyr Gly 
    1340                 1345                 1350             


Trp Arg  Ala Ala Gly Glu Leu  Arg Lys Gly Asp Arg  Val Ala Gly 
    1355                 1360                 1365             


Pro Gly  Gly Ser Gly Asn Ser  Leu Ala Leu Ser Leu  Thr Ala Asp 
    1370                 1375                 1380             


Gln Met  Val Ser Ala Leu Leu  Asp Ala Glu Pro Pro  Ile Leu Tyr 
    1385                 1390                 1395             


Ser Glu  Tyr Asp Pro Thr Ser  Pro Phe Ser Glu Ala  Ser Met Met 
    1400                 1405                 1410             


Gly Leu  Leu Thr Asn Leu Ala  Asp Arg Glu Leu Val  His Met Ile 
    1415                 1420                 1425             


Asn Trp  Ala Lys Arg Val Pro  Gly Phe Val Asp Leu  Thr Leu His 
    1430                 1435                 1440             


Asp Gln  Ala His Leu Leu Glu  Arg Ala Trp Leu Glu  Ile Leu Met 
    1445                 1450                 1455             


Ile Gly  Leu Val Trp Arg Ser  Met Glu His Pro Gly  Lys Leu Leu 
    1460                 1465                 1470             


Phe Ala  Pro Asn Leu Leu Leu  Asp Arg Asn Gln Gly  Lys Cys Val 
    1475                 1480                 1485             


Glu Gly  Met Val Glu Ile Phe  Asp Met Leu Leu Ala  Thr Ser Ser 
    1490                 1495                 1500             


Arg Phe  Arg Met Met Asn Leu  Gln Gly Glu Glu Phe  Val Cys Leu 
    1505                 1510                 1515             


Lys Ser  Ile Ile Leu Leu Asn  Ser Gly Val Tyr Thr  Phe Leu Ser 
    1520                 1525                 1530             


Ser Thr  Leu Lys Ser Leu Glu  Glu Lys Asp His Ile  His Arg Ala 
    1535                 1540                 1545             


Leu Asp  Lys Ile Thr Asp Thr  Leu Ile His Leu Met  Ala Lys Ala 
    1550                 1555                 1560             


Gly Leu  Thr Leu Gln Gln Gln  His Gln Arg Leu Ala  Gln Leu Leu 
    1565                 1570                 1575             


Leu Ile  Leu Ser His Ile Arg  His Met Ser Asn Lys  Gly Met Glu 
    1580                 1585                 1590             


His Leu  Tyr Ser Met Lys Tyr  Lys Asn Val Val Pro  Leu Tyr Asp 
    1595                 1600                 1605             


Leu Leu  Leu Glu Met Leu Asp  Ala His Arg Leu His  Ala Gly Gly 
    1610                 1615                 1620             


Ser Gly  Ala Ser Arg Val Gln  Ala Phe Ala Asp Ala  Leu Asp Asp 
    1625                 1630                 1635             


Lys Phe  Leu His Asp Met Leu  Ala Glu Gly Leu Arg  Tyr Ser Val 
    1640                 1645                 1650             


Ile Arg  Glu Val Leu Pro Thr  Arg Arg Ala Arg Thr  Phe Asp Leu 
    1655                 1660                 1665             


Glu Val  Glu Glu Leu His Thr  Leu Val Ala Glu Gly  Val Val Val 
    1670                 1675                 1680             


His Asn  Cys Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  166
<211>  1816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  166

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Cys Leu Ala Glu Gly Thr 
    210                 215                 220                 


Arg Ile Phe Asp Pro Val Thr Gly Thr Thr His Arg Ile Glu Asp Val 
225                 230                 235                 240 


Val Asp Gly Arg Lys Pro Ile His Val Val Ala Ala Ala Lys Asp Gly 
                245                 250                 255     


Thr Leu Leu Ala Arg Pro Val Val Ser Trp Phe Asp Gln Gly Thr Arg 
            260                 265                 270         


Asp Val Ile Gly Leu Arg Ile Ala Gly Gly Ala Ile Val Trp Ala Thr 
        275                 280                 285             


Pro Asp His Lys Val Leu Thr Glu Tyr Gly Trp Arg Ala Ala Gly Glu 
    290                 295                 300                 


Leu Arg Lys Gly Asp Arg Val Ala Gly Pro Gly Gly Ser Gly Asn Ser 
305                 310                 315                 320 


Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp 
                325                 330                 335     


Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser Pro Phe 
            340                 345                 350         


Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu 
        355                 360                 365             


Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp 
    370                 375                 380                 


Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Arg Ala Trp Leu Glu 
385                 390                 395                 400 


Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys 
                405                 410                 415     


Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys 
            420                 425                 430         


Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser 
        435                 440                 445             


Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys 
    450                 455                 460                 


Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr 
465                 470                 475                 480 


Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu Asp Lys 
                485                 490                 495     


Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu 
            500                 505                 510         


Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His 
        515                 520                 525             


Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met Lys 
    530                 535                 540                 


Tyr Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp 
545                 550                 555                 560 


Ala His Arg Leu His Ala Gly Gly Ser Gly Ala Ser Arg Val Gln Ala 
                565                 570                 575     


Phe Ala Asp Ala Leu Asp Asp Lys Phe Leu His Asp Met Leu Ala Glu 
            580                 585                 590         


Gly Leu Arg Tyr Ser Val Ile Arg Glu Val Leu Pro Thr Arg Arg Ala 
        595                 600                 605             


Arg Thr Phe Asp Leu Glu Val Glu Glu Leu His Thr Leu Val Ala Glu 
    610                 615                 620                 


Gly Val Val Val His Asn Cys Arg Arg Leu Glu Asn Leu Ile Ala Gln 
625                 630                 635                 640 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                645                 650                 655     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            660                 665                 670         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        675                 680                 685             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    690                 695                 700                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
705                 710                 715                 720 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                725                 730                 735     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            740                 745                 750         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        755                 760                 765             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    770                 775                 780                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
785                 790                 795                 800 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                805                 810                 815     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            820                 825                 830         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        835                 840                 845             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    850                 855                 860                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
865                 870                 875                 880 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                885                 890                 895     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            900                 905                 910         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        915                 920                 925             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    930                 935                 940                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
945                 950                 955                 960 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                965                 970                 975     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            980                 985                 990         


Ser Gly Val Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
        995                 1000                 1005             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1025                 1030                 1035             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1040                 1045                 1050             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1055                 1060                 1065             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1070                 1075                 1080             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1085                 1090                 1095             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1100                 1105                 1110             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1115                 1120                 1125             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1130                 1135                 1140             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1145                 1150                 1155             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1160                 1165                 1170             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1175                 1180                 1185             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1190                 1195                 1200             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1205                 1210                 1215             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1220                 1225                 1230             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1235                 1240                 1245             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1250                 1255                 1260             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1265                 1270                 1275             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1280                 1285                 1290             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1295                 1300                 1305             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1310                 1315                 1320             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1325                 1330                 1335             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    1340                 1345                 1350             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    1355                 1360                 1365             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    1370                 1375                 1380             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    1385                 1390                 1395             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    1400                 1405                 1410             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1415                 1420                 1425             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1430                 1435                 1440             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1445                 1450                 1455             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1460                 1465                 1470             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1475                 1480                 1485             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1490                 1495                 1500             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1505                 1510                 1515             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1520                 1525                 1530             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1535                 1540                 1545             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1550                 1555                 1560             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1565                 1570                 1575             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1580                 1585                 1590             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1595                 1600                 1605             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1610                 1615                 1620             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1625                 1630                 1635             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1640                 1645                 1650             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1655                 1660                 1665             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1670                 1675                 1680             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1685                 1690                 1695             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1700                 1705                 1710             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1715                 1720                 1725             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1730                 1735                 1740             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1745                 1750                 1755             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1760                 1765                 1770             


Leu Ser  Gln Leu Gly Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1775                 1780                 1785             


Val Ser  Ser Asp Tyr Lys Asp  His Asp Gly Asp Tyr  Lys Asp His 
    1790                 1795                 1800             


Asp Ile  Asp Tyr Lys Asp Asp  Asp Asp Lys Ala Ala  Gly 
    1805                 1810                 1815     


<210>  167
<211>  153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  167
tgcagtctca tgacttggcc tttgtaggaa aacaccatta gaagagtaga tggttgggta       60

gtggctctct tctgcttaga ctcttgtcta ctatgaataa agggctctat ttgcaaaggc      120

cgtgatgggt tgaagcacat tgagaaagag gct                                   153


<210>  168
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  168
ctcacctggg cgagaaaggt aacttatgtt tcagtagcct ctttctcaat gtgcttcaac       60

ccatcacggc ctttgcaaat agagcccttt attcatagta gacaagagtc taagcagaag      120

agagccacta cccaaccatc tactcttcta atggt                                 155


<210>  169
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  169
ctcttctgct tagactc                                                      17


<210>  170
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  170
gagtctaagc agaagag                                                      17


<210>  171
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  171
gagtctaagc agaagag                                                      17


<210>  172
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  172

Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu 
1               5                   10                  15      


Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Ser 
            20                  25                  30          


Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp 
        35                  40                  45              


Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe 
    50                  55                  60                  


Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Cys Ala Trp 
65                  70                  75                  80  


Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro 
                85                  90                  95      


Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly 
            100                 105                 110         


Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr 
        115                 120                 125             


Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys 
    130                 135                 140                 


Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser 
145                 150                 155                 160 


Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu 
                165                 170                 175     


Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu 
        195                 200                 205             


Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser 
    210                 215                 220                 


Met Lys Tyr Thr Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met 
225                 230                 235                 240 


Leu Asp Ala His Arg Leu His Ala 
                245             


<210>  173
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (228)..(228)
<223>  Xaa can be any amino acid

<400>  173

Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu 
1               5                   10                  15      


Leu Asp Ala Glu Pro Pro Ile Xaa Tyr Ser Glu Tyr Xaa Pro Thr Ser 
            20                  25                  30          


Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp 
        35                  40                  45              


Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe 
    50                  55                  60                  


Val Asp Leu Thr Leu His Asp Gln Ala His Leu Leu Glu Xaa Ala Trp 
65                  70                  75                  80  


Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro 
                85                  90                  95      


Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly 
            100                 105                 110         


Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr 
        115                 120                 125             


Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys 
    130                 135                 140                 


Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser 
145                 150                 155                 160 


Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Ala Leu 
                165                 170                 175     


Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu 
            180                 185                 190         


Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu 
        195                 200                 205             


Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser 
    210                 215                 220                 


Met Lys Tyr Xaa Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met 
225                 230                 235                 240 


Leu Asp Ala His Arg Leu His Ala 
                245             


