                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  cKIT ANTIBODY DRUG CONJUGATES

<130>  PAT056353-WO-PCT

<160>  188   

<170>  PatentIn version 3.5

<210>  1
<211>  5084
<212>  DNA
<213>  Homo sapiens

<400>  1
gatcccatcg cagctaccgc gatgagaggc gctcgcggcg cctgggattt tctctgcgtt       60

ctgctcctac tgcttcgcgt ccagacaggc tcttctcaac catctgtgag tccaggggaa      120

ccgtctccac catccatcca tccaggaaaa tcagacttaa tagtccgcgt gggcgacgag      180

attaggctgt tatgcactga tccgggcttt gtcaaatgga cttttgagat cctggatgaa      240

acgaatgaga ataagcagaa tgaatggatc acggaaaagg cagaagccac caacaccggc      300

aaatacacgt gcaccaacaa acacggctta agcaattcca tttatgtgtt tgttagagat      360

cctgccaagc ttttccttgt tgaccgctcc ttgtatggga aagaagacaa cgacacgctg      420

gtccgctgtc ctctcacaga cccagaagtg accaattatt ccctcaaggg gtgccagggg      480

aagcctcttc ccaaggactt gaggtttatt cctgacccca aggcgggcat catgatcaaa      540

agtgtgaaac gcgcctacca tcggctctgt ctgcattgtt ctgtggacca ggagggcaag      600

tcagtgctgt cggaaaaatt catcctgaaa gtgaggccag ccttcaaagc tgtgcctgtt      660

gtgtctgtgt ccaaagcaag ctatcttctt agggaagggg aagaattcac agtgacgtgc      720

acaataaaag atgtgtctag ttctgtgtac tcaacgtgga aaagagaaaa cagtcagact      780

aaactacagg agaaatataa tagctggcat cacggtgact tcaattatga acgtcaggca      840

acgttgacta tcagttcagc gagagttaat gattctggag tgttcatgtg ttatgccaat      900

aatacttttg gatcagcaaa tgtcacaaca accttggaag tagtagataa aggattcatt      960

aatatcttcc ccatgataaa cactacagta tttgtaaacg atggagaaaa tgtagatttg     1020

attgttgaat atgaagcatt ccccaaacct gaacaccagc agtggatcta tatgaacaga     1080

accttcactg ataaatggga agattatccc aagtctgaga atgaaagtaa tatcagatac     1140

gtaagtgaac ttcatctaac gagattaaaa ggcaccgaag gaggcactta cacattccta     1200

gtgtccaatt ctgacgtcaa tgctgccata gcatttaatg tttatgtgaa tacaaaacca     1260

gaaatcctga cttacgacag gctcgtgaat ggcatgctcc aatgtgtggc agcaggattc     1320

ccagagccca caatagattg gtatttttgt ccaggaactg agcagagatg ctctgcttct     1380

gtactgccag tggatgtgca gacactaaac tcatctgggc caccgtttgg aaagctagtg     1440

gttcagagtt ctatagattc tagtgcattc aagcacaatg gcacggttga atgtaaggct     1500

tacaacgatg tgggcaagac ttctgcctat tttaactttg catttaaagg taacaacaaa     1560

gagcaaatcc atccccacac cctgttcact cctttgctga ttggtttcgt aatcgtagct     1620

ggcatgatgt gcattattgt gatgattctg acctacaaat atttacagaa acccatgtat     1680

gaagtacagt ggaaggttgt tgaggagata aatggaaaca attatgttta catagaccca     1740

acacaacttc cttatgatca caaatgggag tttcccagaa acaggctgag ttttgggaaa     1800

accctgggtg ctggagcttt cgggaaggtt gttgaggcaa ctgcttatgg cttaattaag     1860

tcagatgcgg ccatgactgt cgctgtaaag atgctcaagc cgagtgccca tttgacagaa     1920

cgggaagccc tcatgtctga actcaaagtc ctgagttacc ttggtaatca catgaatatt     1980

gtgaatctac ttggagcctg caccattgga gggcccaccc tggtcattac agaatattgt     2040

tgctatggtg atcttttgaa ttttttgaga agaaaacgtg attcatttat ttgttcaaag     2100

caggaagatc atgcagaagc tgcactttat aagaatcttc tgcattcaaa ggagtcttcc     2160

tgcagcgata gtactaatga gtacatggac atgaaacctg gagtttctta tgttgtccca     2220

accaaggccg acaaaaggag atctgtgaga ataggctcat acatagaaag agatgtgact     2280

cccgccatca tggaggatga cgagttggcc ctagacttag aagacttgct gagcttttct     2340

taccaggtgg caaagggcat ggctttcctc gcctccaaga attgtattca cagagacttg     2400

gcagccagaa atatcctcct tactcatggt cggatcacaa agatttgtga ttttggtcta     2460

gccagagaca tcaagaatga ttctaattat gtggttaaag gaaacgctcg actacctgtg     2520

aagtggatgg cacctgaaag cattttcaac tgtgtataca cgtttgaaag tgacgtctgg     2580

tcctatggga tttttctttg ggagctgttc tctttaggaa gcagccccta tcctggaatg     2640

ccggtcgatt ctaagttcta caagatgatc aaggaaggct tccggatgct cagccctgaa     2700

cacgcacctg ctgaaatgta tgacataatg aagacttgct gggatgcaga tcccctaaaa     2760

agaccaacat tcaagcaaat tgttcagcta attgagaagc agatttcaga gagcaccaat     2820

catatttact ccaacttagc aaactgcagc cccaaccgac agaagcccgt ggtagaccat     2880

tctgtgcgga tcaattctgt cggcagcacc gcttcctcct cccagcctct gcttgtgcac     2940

gacgatgtct gagcagaatc agtgtttggg tcacccctcc aggaatgatc tcttcttttg     3000

gcttccatga tggttatttt cttttctttc aacttgcatc caactccagg atagtgggca     3060

ccccactgca atcctgtctt tctgagcaca ctttagtggc cgatgatttt tgtcatcagc     3120

caccatccta ttgcaaaggt tccaactgta tatattccca atagcaacgt agcttctacc     3180

atgaacagaa aacattctga tttggaaaaa gagagggagg tatggactgg gggccagagt     3240

cctttccaag gcttctccaa ttctgcccaa aaatatggtt gatagtttac ctgaataaat     3300

ggtagtaatc acagttggcc ttcagaacca tccatagtag tatgatgata caagattaga     3360

agctgaaaac ctaagtcctt tatgtggaaa acagaacatc attagaacaa aggacagagt     3420

atgaacacct gggcttaaga aatctagtat ttcatgctgg gaatgagaca taggccatga     3480

aaaaaatgat ccccaagtgt gaacaaaaga tgctcttctg tggaccactg catgagcttt     3540

tatactaccg acctggtttt taaatagagt ttgctattag agcattgaat tggagagaag     3600

gcctccctag ccagcacttg tatatacgca tctataaatt gtccgtgttc atacatttga     3660

ggggaaaaca ccataaggtt tcgtttctgt atacaaccct ggcattatgt ccactgtgta     3720

tagaagtaga ttaagagcca tataagtttg aaggaaacag ttaataccat tttttaagga     3780

aacaatataa ccacaaagca cagtttgaac aaaatctcct cttttagctg atgaacttat     3840

tctgtagatt ctgtggaaca agcctatcag cttcagaatg gcattgtact caatggattt     3900

gatgctgttt gacaaagtta ctgattcact gcatggctcc cacaggagtg ggaaaacact     3960

gccatcttag tttggattct tatgtagcag gaaataaagt ataggtttag cctccttcgc     4020

aggcatgtcc tggacaccgg gccagtatct atatatgtgt atgtacgttt gtatgtgtgt     4080

agacaaatat ttggaggggt atttttgccc tgagtccaag agggtccttt agtacctgaa     4140

aagtaacttg gctttcatta ttagtactgc tcttgtttct tttcacatag ctgtctagag     4200

tagcttacca gaagcttcca tagtggtgca gaggaagtgg aaggcatcag tccctatgta     4260

tttgcagttc acctgcactt aaggcactct gttatttaga ctcatcttac tgtacctgtt     4320

ccttagacct tccataatgc tactgtctca ctgaaacatt taaattttac cctttagact     4380

gtagcctgga tattattctt gtagtttacc tctttaaaaa caaaacaaaa caaaacaaaa     4440

aactcccctt cctcactgcc caatataaaa ggcaaatgtg tacatggcag agtttgtgtg     4500

ttgtcttgaa agattcaggt atgttgcctt tatggtttcc cccttctaca tttcttagac     4560

tacatttaga gaactgtggc cgttatctgg aagtaaccat ttgcactgga gttctatgct     4620

ctcgcacctt tccaaagtta acagattttg gggttgtgtt gtcacccaag agattgttgt     4680

ttgccatact ttgtctgaaa aattcctttg tgtttctatt gacttcaatg atagtaagaa     4740

aagtggttgt tagttataga tgtctaggta cttcaggggc acttcattga gagttttgtc     4800

ttgccatact ttgtctgaaa aattcctttg tgtttctatt gacttcaatg atagtaagaa     4860

aagtggttgt tagttataga tgtctaggta cttcaggggc acttcattga gagttttgtc     4920

aatgtctttt gaatattccc aagcccatga gtccttgaaa atatttttta tatatacagt     4980

aactttatgt gtaaatacat aagcggcgta agtttaaagg atgttggtgt tccacgtgtt     5040

ttattcctgt atgttgtcca attgttgaca gttctgaaga attc                      5084


<210>  2
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Tyr Tyr Met Ala 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Leu Asp Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  7
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  7

Asn Tyr Asp Gly Ser Ser 
1               5       


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  9
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Arg Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Arg Ser 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Leu Asp Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  11
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Gln Gly Lys Lys Leu Trp Ser 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Gln Asp Ile Ser Asn Tyr 
1               5           


<210>  16
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  16

Tyr Thr Ser 
1           


<210>  17
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Lys Lys Leu Trp 
1               5   


<210>  18
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  19
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  20
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  21
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  22
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Tyr Tyr Met Ala 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  23

Asn Ile Asn Gln Ile Ala Gly Ser Thr Tyr Tyr Leu Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  26
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  26

Asn Gln Ile Ala Gly Ser 
1               5       


<210>  27
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  28
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Ile Ala Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Ile Ala Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  30
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  30
gaagtgcaat tggtggaaag cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc gactactaca tggcctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtggccaat atcaaccaaa tcgccggcag cacctactac      180

ctggacagcg tgagaggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaggcgat      300

tactacggca ccacctactg gtacttcgac gtgtggggcc agggcaccac cgtgaccgtc      360

agctcagcta gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gtccagcgtg gtgacagtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagcccc agagctgctg      720

ggcggaccct ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg      780

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggacccaga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaggaat acaagtgcaa ggtctccaac aaggccctgc cagcccccat cgaaaagacc     1020

atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc cccctcccgg     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1260

aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccccc ggcaag                               1356


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  32

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Gln Gly Lys Lys Leu Trp Ser 
1               5               


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Gln Asp Ile Ser Asn Tyr 
1               5           


<210>  35
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr Thr Ser 
1           


<210>  36
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Lys Lys Leu Trp 
1               5   


<210>  37
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  38
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  39
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  39
gagatcgtga tgacccagag ccccgccacc ctgagcctga gccctggcga aagagccacc       60

ctgtcctgca gagccagcca ggacatcagc aactacctga actggtatca gcagaagccc      120

ggccaggccc ccagactgct gatctactac accagccggc tgcagagcgg catccccgcc      180

agattttctg gcagcggcag cggcaccgac tacaccctga ccatcagcag cctggaaccc      240

gaggacttcg ccgtgtacta ctgccagcag ggcaagaagc tgtggtcctt cggcggaggc      300

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  40
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Tyr Tyr Met Ala 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  41

Asn Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Val Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  44
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Gln Asn Thr Gly Ser 
1               5       


<210>  45
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  46
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  48
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  48
gaagtgcaat tggtggaaag cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc gactactaca tggcctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtggccaat atcaaccaaa acaccggcag cacctactac      180

gtggacagcg tgcaaggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaggcgat      300

tactacggca ccacctactg gtacttcgac gtgtggggcc agggcaccac cgtgaccgtc      360

agctcagcta gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gtccagcgtg gtgacagtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagcccc agagctgctg      720

ggcggaccct ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg      780

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggacccaga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaggaat acaagtgcaa ggtctccaac aaggccctgc cagcccccat cgaaaagacc     1020

atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc cccctcccgg     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1260

aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccccc ggcaag                               1356


<210>  49
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  49

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  50

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Gln Gly Lys Lys Leu Trp Ser 
1               5               


<210>  52
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Gln Asp Ile Ser Asn Tyr 
1               5           


<210>  53
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  53

Tyr Thr Ser 
1           


<210>  54
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Lys Lys Leu Trp 
1               5   


<210>  55
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  56
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  57
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  57
gagatcgtga tgacccagag ccccgccacc ctgagcctga gccctggcga aagagccacc       60

ctgtcctgca gagccagcca ggacatcagc aactacctga actggtatca gcagaagccc      120

ggccaggccc ccagactgct gatctactac accagccggc tgcagagcgg catccccgcc      180

agattttctg gcagcggcag cggcaccgac tacaccctga ccatcagcag cctggaaccc      240

gaggacttcg ccgtgtacta ctgccagcag ggcaagaagc tgtggtcctt cggcggaggc      300

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  58
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Tyr Tyr Met Ala 
1               5   


<210>  59
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Leu Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  61
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  62
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  62

Asn Gln Asn Thr Gly Ser 
1               5       


<210>  63
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  64
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  65
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  66
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  66
gaagtgcaat tggtggaaag cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc gactactaca tggcctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtggccagt atcaaccaaa acaccggcag cacctactac      180

ctggacagcg tgcgaggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaggcgat      300

tactacggca ccacctactg gtacttcgac gtgtggggcc agggcaccac cgtgaccgtc      360

agctcagcta gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gtccagcgtg gtgacagtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagcccc agagctgctg      720

ggcggaccct ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg      780

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggacccaga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaggaat acaagtgcaa ggtctccaac aaggccctgc cagcccccat cgaaaagacc     1020

atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc cccctcccgg     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1260

aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccccc ggcaag                               1356


<210>  67
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  68
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  68

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  69
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Gln Gly Lys Lys Leu Trp Ser 
1               5               


<210>  70
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  70

Ser Gln Asp Ile Ser Asn Tyr 
1               5           


<210>  71
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  71

Tyr Thr Ser 
1           


<210>  72
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  72

Gly Lys Lys Leu Trp 
1               5   


<210>  73
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  74
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Lys Lys Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  75
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  75
gagatcgtga tgacccagag ccccgccacc ctgagcctga gccctggcga aagagccacc       60

ctgtcctgca gagccagcca ggacatcagc aactacctga actggtatca gcagaagccc      120

ggccaggccc ccagactgct gatctactac accagccggc tgcagagcgg catccccgcc      180

agattttctg gcagcggcag cggcaccgac tacaccctga ccatcagcag cctggaaccc      240

gaggacttcg ccgtgtacta ctgccagcag ggcaagaagc tgtggtcctt cggcggaggc      300

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  76
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  76

Gly Tyr Tyr Met Ala 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  77

Asn Ile Asn Tyr Pro Gly Ser Ser Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  79
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  79

Gly Phe Ala Phe Ser Gly Tyr 
1               5           


<210>  80
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  80

Asn Tyr Pro Gly Ser Ser 
1               5       


<210>  81
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  81

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  82
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Tyr Pro Gly Ser Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Tyr Pro Gly Ser Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  84
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  84
gaagtgcaat tggtggaaag cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

agctgtgccg ccagcggctt cgccttcagc ggctactaca tggcctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtggccaac atcaactacc ccggcagcag cacctactac      180

ctggacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaggcgat      300

tactacggca ccacctactg gtacttcgac gtgtggggcc agggcaccac cgtgaccgtc      360

agctcagcta gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gtccagcgtg gtgacagtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagcccc agagctgctg      720

ggcggaccct ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg      780

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggacccaga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaggaat acaagtgcaa ggtctccaac aaggccctgc cagcccccat cgaaaagacc     1020

atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc cccctcccgg     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1260

aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccccc ggcaag                               1356


<210>  85
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  86
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  86

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  87
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Gln Gly Arg Arg Leu Trp Ser 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  88

Ser Gln Ser Ile Ser Ser Tyr 
1               5           


<210>  89
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  89

Tyr Thr Ser 
1           


<210>  90
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  90

Gly Arg Arg Leu Trp 
1               5   


<210>  91
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Arg Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  92
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Arg Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  93
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  93
gatatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca gagcatcagc agctacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagccggc tgcagagcgg cgtgcccagc      180

agattttctg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggccgccgcc tgtggtcctt cggcggaggc      300

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  94
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  94

Asp Tyr Tyr Met Ala 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  95

Asn Ile Asn Gln Ile Ala Gly Ser Thr Tyr Tyr Val Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  96

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  97
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  97

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  98
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  98

Asn Gln Ile Ala Gly Ser 
1               5       


<210>  99
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  100
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Ile Ala Gly Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  101
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Ile Ala Gly Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  102
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  102
gaagtgcaat tggtggaaag cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc gactactaca tggcctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtggccaat atcaaccaaa tcgccggcag cacctactac      180

gtggacagcg tgcaaggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaggcgat      300

tactacggca ccacctactg gtacttcgac gtgtggggcc agggcaccac cgtgaccgtc      360

agctcagcta gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gtccagcgtg gtgacagtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagcccc agagctgctg      720

ggcggaccct ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg      780

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggacccaga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaggaat acaagtgcaa ggtctccaac aaggccctgc cagcccccat cgaaaagacc     1020

atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc cccctcccgg     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1260

aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccccc ggcaag                               1356


<210>  103
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  103

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  104
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  104

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  105
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  105

Gln Gln Gly Arg Arg Leu Trp Ser 
1               5               


<210>  106
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Gln Ser Ile Ser Ser Tyr 
1               5           


<210>  107
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  107

Tyr Thr Ser 
1           


<210>  108
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Arg Arg Leu Trp 
1               5   


<210>  109
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Arg Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  110
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Arg Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  111
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  111
gatatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca gagcatcagc agctacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagccggc tgcagagcgg cgtgcccagc      180

agattttctg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggccgccgcc tgtggtcctt cggcggaggc      300

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  112
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  112

Asp Tyr Tyr Met Ala 
1               5   


<210>  113
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  113

Ser Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Leu Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  114

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  115
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  115

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  116
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  116

Asn Gln Asn Thr Gly Ser 
1               5       


<210>  117
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  117

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  118
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  119
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Gln Asn Thr Gly Ser Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  120
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  120
gaagtgcaat tggtggaaag cggcggaggc ctggtgcagc ctggcggctc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc gactactaca tggcctgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtggccagt atcaaccaaa acaccggcag cacctactac      180

ctggacagcg tgcgaggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaggcgat      300

tactacggca ccacctactg gtacttcgac gtgtggggcc agggcaccac cgtgaccgtc      360

agctcagcta gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgacctcc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gtccagcgtg gtgacagtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagcccc agagctgctg      720

ggcggaccct ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg      780

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggacccaga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag      900

tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      960

ggcaaggaat acaagtgcaa ggtctccaac aaggccctgc cagcccccat cgaaaagacc     1020

atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc cccctcccgg     1080

gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1260

aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agagcctgag cctgtccccc ggcaag                               1356


<210>  121
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  121

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  122

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  123
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  123

Gln Gln Gly Arg Arg Leu Trp Ser 
1               5               


<210>  124
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  124

Ser Gln Ser Ile Ser Ser Tyr 
1               5           


<210>  125
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  125

Tyr Thr Ser 
1           


<210>  126
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  126

Gly Arg Arg Leu Trp 
1               5   


<210>  127
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Arg Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  128
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Arg Arg Leu Trp Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  129
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  129
gatatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgtc gggccagcca gagcatcagc agctacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagccggc tgcagagcgg cgtgcccagc      180

agattttctg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggccgccgcc tgtggtcctt cggcggaggc      300

accaaggtgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcataaggtg tacgcctgcg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  130
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Tyr Ala Ile Ser 
1               5   


<210>  131
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  131

Gly Ile Ile Pro Met Ser Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  132

Asp Tyr Gly Pro Glu Ala Pro Asp Tyr Gly Gln Ser Thr Ser Tyr Phe 
1               5                   10                  15      


Trp Tyr Tyr Ala Phe Asp Pro 
            20              


<210>  133
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  133

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  134
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  134

Ile Pro Met Ser Gly Arg 
1               5       


<210>  135
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  135

Asp Tyr Gly Pro Glu Ala Pro Asp Tyr Gly Gln Ser Thr Ser Tyr Phe 
1               5                   10                  15      


Trp Tyr Tyr Ala Phe Asp Pro 
            20              


<210>  136
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Ser Gly Arg Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Pro Glu Ala Pro Asp Tyr Gly Gln Ser Thr Ser 
            100                 105                 110         


Tyr Phe Trp Tyr Tyr Ala Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  137
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Ser Gly Arg Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Pro Glu Ala Pro Asp Tyr Gly Gln Ser Thr Ser 
            100                 105                 110         


Tyr Phe Trp Tyr Tyr Ala Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  138
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  138
caggtgcagc tggtgcagtc aggcgccgaa gtgaagaaac ccggctctag cgtgaaagtc       60

agctgtaaag ctagtggggg caccttctct agctacgcta ttagctgggt cagacaggcc      120

ccaggtcaag gcttggagtg gatgggcgga attatcccta tgagcggtag aactacctac      180

gctcagaaat ttcagggtag agtgactatc accgccgacg agtctactag caccgcctat      240

atggaactga gttctctgag gtcagaggac accgccgtct actactgcgc tagagactac      300

ggccccgagg cccccgacta cggtcaatca actagctact tctggtacta cgccttcgac      360

ccttggggtc aaggcaccct ggtcaccgtg tcttcagcta gcactaaggg cccaagtgtg      420

tttcccctgg cccccagcag caagtctact tccggcggaa ctgctgccct gggttgcctg      480

gtgaaggact acttccccga gcccgtgaca gtgtcctgga actctggggc tctgacttcc      540

ggcgtgcaca ccttccccgc cgtgctgcag agcagcggcc tgtacagcct gagcagcgtg      600

gtgacagtgc cctccagctc tctgggaacc cagacctata tctgcaacgt gaaccacaag      660

cccagcaaca ccaaggtgga caagagagtg gagcccaaga gctgcgacaa gacccacacc      720

tgccccccct gcccagctcc agaactgctg ggagggcctt ccgtgttcct gttccccccc      780

aagcccaagg acaccctgat gatcagcagg acccccgagg tgacctgcgt ggtggtggac      840

gtgtcccacg aggacccaga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac      900

aacgccaaga ccaagcccag agaggagcag tacaacagca cctacagggt ggtgtccgtg      960

ctgaccgtgc tgcaccagga ctggctgaac ggcaaagaat acaagtgcaa agtctccaac     1020

aaggccctgc cagccccaat cgaaaagaca atcagcaagg ccaagggcca gccacgggag     1080

ccccaggtgt acaccctgcc ccccagccgg gaggagatga ccaagaacca ggtgtccctg     1140

acctgtctgg tgaagggctt ctaccccagc gatatcgccg tggagtggga gagcaacggc     1200

cagcccgaga acaactacaa gaccaccccc ccagtgctgg acagcgacgg cagcttcttc     1260

ctgtacagca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttcagctgc     1320

agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag cctgagcccc     1380

ggcaag                                                                1386


<210>  139
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  139

Ser Gly Asp Asn Ile Pro Ser Tyr Phe Val His 
1               5                   10      


<210>  140
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  140

Asp Asp Asn Asp Arg Pro Ser 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Ser Ser Trp Asp Gln Asp Thr Val Val 
1               5                   


<210>  142
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  142

Asp Asn Ile Pro Ser Tyr Phe 
1               5           


<210>  143
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  143

Asp Asp Asn 
1           


<210>  144
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  144

Trp Asp Gln Asp Thr Val 
1               5       


<210>  145
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  145

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Pro Ser Tyr Phe Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Gln Asp Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  146
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  146

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Pro Ser Tyr Phe Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Gln Asp Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  147
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  147
gatatcgagc tgactcagcc ccctagcgtc agcgtcagcc ctggtcaaac cgcctctatc       60

acctgtagcg gcgataatat ccctagctac ttcgtgcact ggtatcagca gaagcccggt      120

caagcccccg tgctggtgat ctacgacgat aacgatagac ctagcggaat ccccgagcgg      180

tttagcggct ctaatagcgg taacaccgct accctgacta ttagcggcac tcaggccgag      240

gacgaggccg actactactg ctctagctgg gatcaggaca ccgtggtgtt cggcggaggc      300

actaagctga ccgtgctggg tcaacctaag gctgccccca gcgtgaccct gttccccccc      360

agcagcgagg agctgcaggc caacaaggcc accctggtgt gcctgatcag cgacttctac      420

ccaggcgccg tgaccgtggc ctggaaggcc gacagcagcc ccgtgaaggc cggcgtggag      480

accaccaccc ccagcaagca gagcaacaac aagtacgccg ccagcagcta cctgagcctg      540

acccccgagc agtggaagag ccacaggtcc tacagctgcc aggtgaccca cgagggcagc      600

accgtggaaa agaccgtggc cccaaccgag tgcagc                                636


<210>  148
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  148

Ser Tyr Ala Ile Ser 
1               5   


<210>  149
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  149

Thr Ile Gly Pro Phe Glu Gly Gln Pro Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  150
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  150

Gly Gly Tyr Ile Ser Asp Phe Asp Val 
1               5                   


<210>  151
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  151

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  152
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  152

Gly Pro Phe Glu Gly Gln 
1               5       


<210>  153
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  153

Gly Tyr Ile Ser Asp Phe Asp Val 
1               5               


<210>  154
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  154

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Gly Pro Phe Glu Gly Gln Pro Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Ile Ser Asp Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  155
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  155

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Gly Pro Phe Glu Gly Gln Pro Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Ile Ser Asp Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  156
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  156
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt       60

agctgcaaag catccggagg gacgtttagc agctatgcga ttagctgggt gcgccaggcc      120

ccgggccagg gcctcgagtg gatgggcact atcggtccgt tcgaaggcca gccgcgttac      180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat      240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtggtggt      300

tacatctctg acttcgatgt ttggggccaa ggcaccctgg tgactgttag ctcagcctcc      360

accaagggtc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  157
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  157

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  158
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  158

Asp Ala Ser Ser Leu Gln Ser 
1               5           


<210>  159
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  159

Gln Gln Tyr Tyr Glu Ser Ile Thr 
1               5               


<210>  160
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  160

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  161
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  161

Asp Ala Ser Ser Leu Gln Ser 
1               5           


<210>  162
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  162

Gln Gln Tyr Tyr Glu Ser Ile Thr 
1               5               


<210>  163
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  163

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Glu Ser Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  164
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Tyr Glu Ser Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  165
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  165
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc       60

attacctgca gagccagcca gtctatttct aactacctgg cttggtacca gcagaaaccg      120

ggcaaagcgc cgaaactatt aatctacgac gcttcttctc tgcaaagcgg cgtgccgagc      180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg      240

gaagactttg cgacctatta ttgccagcag tactactacg aatctatcac ctttggccag      300

ggcacgaaag ttgaaattaa acgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gaaagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  166
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  166

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala 
1               5                   10  


<210>  167
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  167

Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Leu Asp Ser 
1               5                   10                  


<210>  168
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  168

Gly Asp Tyr Tyr Gly Thr Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  169
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  169

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  170
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  170

Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210>  171
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  171

Gln Gln Gly Lys Lys Leu Trp Ser 
1               5               


<210>  172
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His Pro 
1               5                   10                  15      


Gly Lys Ser Asp Leu Ile Val Arg Val Gly Asp Glu Ile Arg Leu Leu 
            20                  25                  30          


Cys Thr Asp Pro Gly Phe Val Lys Trp Thr Phe Glu Ile Leu Asp Glu 
        35                  40                  45              


Thr Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu Ala 
    50                  55                  60                  


Thr Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His Gly Leu Ser Asn 
65                  70                  75                  80  


Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu Val Asp 
                85                  90                  95      


Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys Pro 
            100                 105                 110         


Leu Thr Asp Pro Glu Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln Gly 
        115                 120                 125             


Lys Pro Leu Pro Lys Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala Gly 
    130                 135                 140                 


Ile Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu His 
145                 150                 155                 160 


Cys Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile 
                165                 170                 175     


Leu Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val Ser 
            180                 185                 190         


Lys Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys 
        195                 200                 205             


Thr Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu 
    210                 215                 220                 


Asn Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly 
225                 230                 235                 240 


Asp Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg 
                245                 250                 255     


Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly 
            260                 265                 270         


Ser Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Phe Ile 
        275                 280                 285             


Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn Asp Gly Glu 
    290                 295                 300                 


Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu His 
305                 310                 315                 320 


Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys Trp Glu Asp 
                325                 330                 335     


Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu Leu 
            340                 345                 350         


His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu 
        355                 360                 365             


Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn Val Tyr Val 
    370                 375                 380                 


Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met 
385                 390                 395                 400 


Leu Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr 
                405                 410                 415     


Phe Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val 
            420                 425                 430         


Asp Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val 
        435                 440                 445             


Val Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val 
    450                 455                 460                 


Glu Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn 
465                 470                 475                 480 


Phe Ala Phe Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Arg 
                485                 490                 495     


Ser His His His His His His 
            500             


<210>  173
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  173

Gln Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His Pro 
1               5                   10                  15      


Gly Lys Ser Asp Leu Ile Val Arg Val Gly Asp Glu Ile Arg Leu Leu 
            20                  25                  30          


Cys Thr Asp Pro Gly Phe Val Lys Trp Thr Phe Glu Ile Leu Asp Glu 
        35                  40                  45              


Thr Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu Ala 
    50                  55                  60                  


Thr Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His Gly Leu Ser Asn 
65                  70                  75                  80  


Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu Val Asp 
                85                  90                  95      


Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys Pro 
            100                 105                 110         


Leu Thr Asp Pro Glu Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln Gly 
        115                 120                 125             


Lys Pro Leu Pro Lys Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala Gly 
    130                 135                 140                 


Ile Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu His 
145                 150                 155                 160 


Cys Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile 
                165                 170                 175     


Leu Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val Ser 
            180                 185                 190         


Lys Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys 
        195                 200                 205             


Thr Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu 
    210                 215                 220                 


Asn Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly 
225                 230                 235                 240 


Asp Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg 
                245                 250                 255     


Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly 
            260                 265                 270         


Ser Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Arg Ser 
        275                 280                 285             


His His His His His His 
    290                 


<210>  174
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  174

Gly Phe Ile Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn 
1               5                   10                  15      


Asp Gly Glu Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys 
            20                  25                  30          


Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys 
        35                  40                  45              


Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val 
    50                  55                  60                  


Ser Glu Leu His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr 
65                  70                  75                  80  


Thr Phe Leu Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn 
                85                  90                  95      


Val Tyr Val Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val 
            100                 105                 110         


Asn Gly Met Leu Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile 
        115                 120                 125             


Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val 
    130                 135                 140                 


Leu Pro Val Asp Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly 
145                 150                 155                 160 


Lys Leu Val Val Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn 
                165                 170                 175     


Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala 
            180                 185                 190         


Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn Lys Glu Gln Ile His Pro 
        195                 200                 205             


His Thr Leu Phe Thr Pro Arg Ser His His His His His His 
    210                 215                 220         


<210>  175
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  175

Ser Gln Pro Ser Ala Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His 
1               5                   10                  15      


Pro Ala Gln Ser Glu Leu Ile Val Glu Ala Gly Asp Thr Leu Ser Leu 
            20                  25                  30          


Thr Cys Ile Asp Pro Asp Phe Val Arg Trp Thr Phe Lys Thr Tyr Phe 
        35                  40                  45              


Asn Glu Met Val Glu Asn Lys Lys Asn Glu Trp Ile Gln Glu Lys Ala 
    50                  55                  60                  


Glu Ala Thr Arg Thr Gly Thr Tyr Thr Cys Ser Asn Ser Asn Gly Leu 
65                  70                  75                  80  


Thr Ser Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu 
                85                  90                  95      


Val Gly Leu Pro Leu Phe Gly Lys Glu Asp Ser Asp Ala Leu Val Arg 
            100                 105                 110         


Cys Pro Leu Thr Asp Pro Gln Val Ser Asn Tyr Ser Leu Ile Glu Cys 
        115                 120                 125             


Asp Gly Lys Ser Leu Pro Thr Asp Leu Thr Phe Val Pro Asn Pro Lys 
    130                 135                 140                 


Ala Gly Ile Thr Ile Lys Asn Val Lys Arg Ala Tyr His Arg Leu Cys 
145                 150                 155                 160 


Val Arg Cys Ala Ala Gln Arg Asp Gly Thr Trp Leu His Ser Asp Lys 
                165                 170                 175     


Phe Thr Leu Lys Val Arg Ala Ala Ile Lys Ala Ile Pro Val Val Ser 
            180                 185                 190         


Val Pro Glu Thr Ser His Leu Leu Lys Lys Gly Asp Thr Phe Thr Val 
        195                 200                 205             


Val Cys Thr Ile Lys Asp Val Ser Thr Ser Val Asn Ser Met Trp Leu 
    210                 215                 220                 


Lys Met Asn Pro Gln Pro Gln His Ile Ala Gln Val Lys His Asn Ser 
225                 230                 235                 240 


Trp His Arg Gly Asp Phe Asn Tyr Glu Arg Gln Glu Thr Leu Thr Ile 
                245                 250                 255     


Ser Ser Ala Arg Val Asp Asp Ser Gly Val Phe Met Cys Tyr Ala Asn 
            260                 265                 270         


Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr Leu Lys Val Val Glu 
        275                 280                 285             


Lys Gly Phe Ile Asn Ile Ser Pro Val Lys Asn Thr Thr Val Phe Val 
    290                 295                 300                 


Thr Asp Gly Glu Asn Val Asp Leu Val Val Glu Tyr Glu Ala Tyr Pro 
305                 310                 315                 320 


Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Ser Ala Asn 
                325                 330                 335     


Lys Gly Lys Asp Tyr Val Lys Ser Asp Asn Lys Ser Asn Ile Arg Tyr 
            340                 345                 350         


Val Asn Gln Leu Arg Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
        355                 360                 365             


Tyr Thr Phe Leu Val Ser Asn Ser Asp Ala Ser Ala Ser Val Thr Phe 
    370                 375                 380                 


Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu 
385                 390                 395                 400 


Ile Asn Gly Met Leu Gln Cys Val Ala Glu Gly Phe Pro Glu Pro Thr 
                405                 410                 415     


Ile Asp Trp Tyr Phe Cys Thr Gly Ala Glu Gln Arg Cys Thr Thr Pro 
            420                 425                 430         


Val Ser Pro Val Asp Val Gln Val Gln Asn Val Ser Val Ser Pro Phe 
        435                 440                 445             


Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser Ser Val Phe Arg His 
    450                 455                 460                 


Asn Gly Thr Val Glu Cys Lys Ala Ser Asn Asp Val Gly Lys Ser Ser 
465                 470                 475                 480 


Ala Phe Phe Asn Phe Ala Phe Lys Glu Gln Ile Gln Ala His Thr Leu 
                485                 490                 495     


Phe Thr Pro Leu Glu Val Leu Phe Gln Gly Pro Arg Ser Pro Arg Gly 
            500                 505                 510         


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
        515                 520                 525             


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
    530                 535                 540                 


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
                565                 570                 575     


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
            580                 585                 590         


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
        595                 600                 605             


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
    610                 615                 620                 


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
625                 630                 635                 640 


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
                645                 650                 655     


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
            660                 665                 670         


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
        675                 680                 685             


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
    690                 695                 700                 


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
705                 710                 715                 720 


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
                725                 730                 735     


Arg Thr Pro Gly Lys 
            740     


<210>  176
<211>  741
<212>  PRT
<213>  Homo sapiens

<400>  176

Ser Gln Pro Ser Ala Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile Gln 
1               5                   10                  15      


Pro Ala Gln Ser Glu Leu Ile Val Glu Ala Gly Asp Thr Ile Arg Leu 
            20                  25                  30          


Thr Cys Thr Asp Pro Ala Phe Val Lys Trp Thr Phe Glu Ile Leu Asp 
        35                  40                  45              


Val Arg Ile Glu Asn Lys Gln Ser Glu Trp Ile Arg Glu Lys Ala Glu 
    50                  55                  60                  


Ala Thr His Thr Gly Lys Tyr Thr Cys Val Ser Gly Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Val Leu Phe Leu Val 
                85                  90                  95      


Gly Leu Pro Leu Phe Gly Lys Glu Asp Asn Asp Ala Leu Val Arg Cys 
            100                 105                 110         


Pro Leu Thr Asp Pro Gln Val Ser Asn Tyr Ser Leu Ile Glu Cys Asp 
        115                 120                 125             


Gly Lys Ser Leu Pro Thr Asp Leu Lys Phe Val Pro Asn Pro Lys Ala 
    130                 135                 140                 


Gly Ile Thr Ile Lys Asn Val Lys Arg Ala Tyr His Arg Leu Cys Ile 
145                 150                 155                 160 


Arg Cys Ala Ala Gln Arg Glu Gly Lys Trp Met Arg Ser Asp Lys Phe 
                165                 170                 175     


Thr Leu Lys Val Arg Ala Ala Ile Lys Ala Ile Pro Val Val Ser Val 
            180                 185                 190         


Pro Glu Thr Ser His Leu Leu Lys Glu Gly Asp Thr Phe Thr Val Ile 
        195                 200                 205             


Cys Thr Ile Lys Asp Val Ser Thr Ser Val Asp Ser Met Trp Ile Lys 
    210                 215                 220                 


Leu Asn Pro Gln Pro Gln Ser Lys Ala Gln Val Lys Arg Asn Ser Trp 
225                 230                 235                 240 


His Gln Gly Asp Phe Asn Tyr Glu Arg Gln Glu Thr Leu Thr Ile Ser 
                245                 250                 255     


Ser Ala Arg Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn 
            260                 265                 270         


Thr Phe Gly Ser Ala Asn Val Thr Thr Thr Leu Lys Val Val Glu Lys 
        275                 280                 285             


Gly Phe Ile Asn Ile Phe Pro Val Lys Asn Thr Thr Val Phe Val Thr 
    290                 295                 300                 


Asp Gly Glu Asn Val Asp Leu Val Val Glu Phe Glu Ala Tyr Pro Lys 
305                 310                 315                 320 


Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Pro Thr Asn Arg 
                325                 330                 335     


Gly Glu Asp Tyr Val Lys Ser Asp Asn Gln Ser Asn Ile Arg Tyr Val 
            340                 345                 350         


Asn Glu Leu Arg Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr 
        355                 360                 365             


Thr Phe Leu Val Ser Asn Ser Asp Val Ser Ala Ser Val Thr Phe Asp 
    370                 375                 380                 


Val Tyr Val Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Met 
385                 390                 395                 400 


Asn Gly Arg Leu Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile 
                405                 410                 415     


Asp Trp Tyr Phe Cys Thr Gly Ala Glu Gln Arg Cys Thr Val Pro Val 
            420                 425                 430         


Pro Pro Val Asp Val Gln Ile Gln Asn Ala Ser Val Ser Pro Phe Gly 
        435                 440                 445             


Lys Leu Val Val Gln Ser Ser Ile Asp Ser Ser Val Phe Arg His Asn 
    450                 455                 460                 


Gly Thr Val Glu Cys Lys Ala Ser Asn Ala Val Gly Lys Ser Ser Ala 
465                 470                 475                 480 


Phe Phe Asn Phe Ala Phe Lys Gly Asn Ser Lys Glu Gln Ile Gln Pro 
                485                 490                 495     


His Thr Leu Phe Thr Pro Arg Ser Leu Glu Val Leu Phe Gln Gly Pro 
            500                 505                 510         


Gly Ser Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu 
        515                 520                 525             


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
    530                 535                 540                 


Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
                565                 570                 575     


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
            580                 585                 590         


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
        595                 600                 605             


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro 
625                 630                 635                 640 


Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu 
                645                 650                 655     


Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala 
            660                 665                 670         


Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr 
        675                 680                 685             


Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
    690                 695                 700                 


Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser 
705                 710                 715                 720 


Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser 
                725                 730                 735     


Arg Ser Leu Gly Lys 
            740     


<210>  177
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gln Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro 
            20                  25                  30          


Ser Ile His Pro Ala Lys Ser Glu Leu Ile Val Arg Val Gly Asn Glu 
        35                  40                  45              


Ile Arg Leu Leu Cys Ile Asp Pro Gly Phe Val Lys Trp Thr Phe Glu 
    50                  55                  60                  


Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu 
65                  70                  75                  80  


Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His 
                85                  90                  95      


Gly Leu Ser Ser Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu 
            100                 105                 110         


Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu 
        115                 120                 125             


Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr Ser Tyr Ser Leu Lys 
    130                 135                 140                 


Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu Arg Phe Val Pro Asp 
145                 150                 155                 160 


Pro Lys Ala Gly Ile Thr Ile Lys Ser Val Lys Arg Ala Tyr His Arg 
                165                 170                 175     


Leu Cys Leu His Cys Ser Ala Asp Gln Glu Gly Lys Ser Val Leu Ser 
            180                 185                 190         


Asp Lys Phe Ile Leu Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val 
        195                 200                 205             


Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe 
    210                 215                 220                 


Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr 
225                 230                 235                 240 


Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser 
                245                 250                 255     


Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile 
            260                 265                 270         


Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn 
        275                 280                 285             


Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp 
    290                 295                 300                 


Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val 
305                 310                 315                 320 


Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro 
                325                 330                 335     


Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp 
            340                 345                 350         


Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr 
        355                 360                 365             


Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr 
    370                 375                 380                 


Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn Ala Ser Ile Ala Phe 
385                 390                 395                 400 


Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu 
                405                 410                 415     


Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr 
            420                 425                 430         


Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser 
        435                 440                 445             


Val Leu Pro Val Asp Val Gln Thr Leu Asn Ala Ser Gly Pro Pro Phe 
    450                 455                 460                 


Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His 
465                 470                 475                 480 


Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser 
                485                 490                 495     


Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn Lys Glu Gln Ile His 
            500                 505                 510         


Pro His Thr Leu Phe Thr Pro Arg Ser His His His His His His 
        515                 520                 525         


<210>  178
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  178

Gln Pro Ser Val Ser Pro Gly Glu Pro Ser Pro Pro Ser Ile His Pro 
1               5                   10                  15      


Gly Lys Ser Asp Leu Ile Val Arg Val Gly Asp Glu Ile Arg Leu Leu 
            20                  25                  30          


Cys Thr Asp Pro Gly Phe Val Lys Trp Thr Phe Glu Ile Leu Asp Glu 
        35                  40                  45              


Thr Asn Glu Asn Lys Gln Asn Glu Trp Ile Thr Glu Lys Ala Glu Ala 
    50                  55                  60                  


Thr Asn Thr Gly Lys Tyr Thr Cys Thr Asn Lys His Gly Leu Ser Asn 
65                  70                  75                  80  


Ser Ile Tyr Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu Val Asp 
                85                  90                  95      


Arg Ser Leu Tyr Gly Lys Glu Asp Asn Asp Thr Leu Val Arg Cys Pro 
            100                 105                 110         


Leu Thr Asp Pro Glu Val Thr Asn Tyr Ser Leu Lys Gly Cys Gln Gly 
        115                 120                 125             


Lys Pro Leu Pro Lys Asp Leu Arg Phe Ile Pro Asp Pro Lys Ala Gly 
    130                 135                 140                 


Ile Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu His 
145                 150                 155                 160 


Cys Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile 
                165                 170                 175     


Leu Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val Ser 
            180                 185                 190         


Lys Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys 
        195                 200                 205             


Thr Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu 
    210                 215                 220                 


Asn Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly 
225                 230                 235                 240 


Asp Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg 
                245                 250                 255     


Val Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly 
            260                 265                 270         


Ser Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Phe Ile 
        275                 280                 285             


Asn Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn Asp Gly Glu 
    290                 295                 300                 


Asn Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu His 
305                 310                 315                 320 


Gln Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys Trp Glu Asp 
                325                 330                 335     


Tyr Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu Leu 
            340                 345                 350         


His Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu 
        355                 360                 365             


Val Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn Val Tyr Val 
    370                 375                 380                 


Asn Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met 
385                 390                 395                 400 


Leu Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr 
                405                 410                 415     


Phe Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val 
            420                 425                 430         


Asp Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val 
        435                 440                 445             


Val Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val 
    450                 455                 460                 


Glu Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn 
465                 470                 475                 480 


Phe Ala Phe Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Arg 
                485                 490                 495     


Ser His His His His His His 
            500             


<210>  179
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  179

Val Phe Val Arg Asp Pro Ala Lys Leu Phe Leu 
1               5                   10      


<210>  180
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  180

His Cys Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu 
1               5                   10                  


<210>  181
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  181

Asp Pro Ala Lys Leu 
1               5   


<210>  182
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  182

Gln Glu Gly Lys Ser Val Leu Ser Glu 
1               5                   


<210>  183
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  183

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
1               5                   10                  15      


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
225                 230                 235                 240 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


<210>  184
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  184

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15      


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            20                  25                  30          


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        35                  40                  45              


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    50                  55                  60                  


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
65                  70                  75                  80  


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                85                  90                  95      


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105             


<210>  185
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
1               5                   10                  15      


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
225                 230                 235                 240 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


<210>  186
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  186

Cys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15      


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            20                  25                  30          


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        35                  40                  45              


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    50                  55                  60                  


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
65                  70                  75                  80  


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                85                  90                  95      


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105             


<210>  187
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  187

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
1               5                   10                  15      


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Cys Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
225                 230                 235                 240 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


<210>  188
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  188

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
1               5                   10                  15      


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
225                 230                 235                 240 


Glu Met Thr Cys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


