                         SEQUENCE LISTING

<110>  INTERNATIONAL - DRUG - DEVELOPMENT - BIOTECH
       UNIVERSITE CLAUDE BERNARD LYON 1
       HOSPICES CIVILS DE LYON
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       CENTRE LEON BERARD
 
<120>  ANTI-CK8 ANTIBODIES FOR USE IN THE TREATMENT OF CANCERS 

<130>  B368089D32477

<150>  FR1457704
<151>  2014-08-08

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  Acides amins de la position 338  366 de la CK8 humaine avec une
       cystine en position C-terminale

<400>  1

Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys Leu 
1               5                   10                  15      


Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Cys 
            20                  25                  30  


<210>  2
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Acides amins de la position 338  357 de la CK8 humaine avec une
       cystine en position C-terminale

<400>  2

Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys Leu 
1               5                   10                  15      


Ser Glu Leu Glu Cys 
            20      


<210>  3
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  Acides amins de la position 358  366 de la CK8 humaine avec une
       cystine en position C-terminale

<400>  3

Ala Ala Leu Gln Arg Ala Lys Gln Asp Cys 
1               5                   10  


<210>  4
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  Acides amins de la position 354  366 de la CK8 humaine avec une
       cystine en position C-terminale

<400>  4

Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Cys 
1               5                   10                  


<210>  5
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 5

<400>  5

Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys Leu 
1               5                   10                  15      


Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
            20                  25                  


<210>  6
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 6

<400>  6

Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 7

<400>  7

Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10  


<210>  8
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 8

<400>  8

Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10      


<210>  9
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 9

<400>  9

Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10          


<210>  10
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 10

<400>  10

Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10              


<210>  11
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 11

<400>  11

Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10                  


<210>  12
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 12

<400>  12

Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10                  15  


<210>  13
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 13

<400>  13

Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp 
1               5                   10                  15      


<210>  14
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 14

<400>  14

Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln 
1               5                   10                  15      


Asp 
    


<210>  15
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 15

<400>  15

Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys 
1               5                   10                  15      


Gln Asp 
        


<210>  16
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 16

<400>  16

Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala 
1               5                   10                  15      


Lys Gln Asp 
            


<210>  17
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 17

<400>  17

Cys Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


Gln Arg Ala Lys Gln Asp 
            20          


<210>  18
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 18

<400>  18

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


Gln Arg Ala Lys Gln 
            20      


<210>  19
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 19

<400>  19

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


Gln Arg Ala Lys 
            20  


<210>  20
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 20

<400>  20

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


Gln Arg Ala 
            


<210>  21
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 21

<400>  21

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


Gln Arg 
        


<210>  22
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 22

<400>  22

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


Gln 
    


<210>  23
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 23

<400>  23

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu 
1               5                   10                  15      


<210>  24
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 24

<400>  24

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala 
1               5                   10                  15  


<210>  25
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 25

<400>  25

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala 
1               5                   10                  


<210>  26
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 26

<400>  26

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu 
1               5                   10              


<210>  27
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 27

<400>  27

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu 
1               5                   10          


<210>  28
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Peptide 28

<400>  28

Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu 
1               5                   10      


<210>  29
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Acides amins de la position 353  360 de la CK8 humaine

<400>  29

Leu Ser Glu Leu Glu Ala Ala Leu 
1               5               


<210>  30
<211>  306
<212>  DNA
<213>  artificial

<220>
<223>  VL mD-A10

<400>  30
aacattgtta tgacccaggc cgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtcttctg tatagtaatg gcaacactta tttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag cgcctgatat attatatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcaga gggtcaggaa ctgatttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaaagtct agaatatcct      300

ttcacg                                                                 306


<210>  31
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  VL  mD-A10

<400>  31

Asn Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Arg Leu Ile Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  32
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  VH mD-A10

<400>  32
gaagtgcagc tgttggagac tggaggaggc ttggtgcaac cgggggggtc acggggactc       60

tcttgtgaag gctcagggtt tacttttagt ggcttctgga tgagctgggt tcgacagaca      120

cctgggaaga ccctggagtg gattggagac attaattctg atggcagtgc aataaaatac      180

gcaccatcca taaaggatcg attcactatc ttcagagaca atgacaagag caccctgtac      240

ctgcagatga gcaatgtgcg atctgaggac acagccacgt atttctgtat cgcccattac      300

tccggtgggg ggtttgctta ctggggtcaa ggaacctcgg tcaccgtctc ctca            354


<210>  33
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  VH mD-A10

<400>  33

Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Gly Leu Ser Cys Glu Gly Ser Gly Phe Thr Phe Ser Gly Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Thr Pro Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asp Gly Ser Ala Ile Lys Tyr Ala Pro Ser Ile 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Phe Arg Asp Asn Asp Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Val Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ile Ala His Tyr Ser Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  34
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 VL mD-A10

<400>  34

Lys Ser Leu Leu Tyr Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  35
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 VL mD-A10

<400>  35

Tyr Met Ser 
1           


<210>  36
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 VL mD-A10

<400>  36

Met Gln Ser Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 VH mD-A10

<400>  37

Gly Phe Thr Phe Ser Gly Phe Trp 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 VH mD-A10

<400>  38

Ile Asn Ser Asp Gly Ser Ala Ile 
1               5               


<210>  39
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 VH mD-A10

<400>  39

Ile Ala His Tyr Ser Gly Gly Gly Phe Ala Tyr 
1               5                   10      


<210>  40
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 VH HzD-A10

<400>  40

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 VH HzD-A10

<400>  41

Ile Asn Ser Asp Gly Ser Ser Thr 
1               5               


<210>  42
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 VL HzD-A10

<400>  42

Lys Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  43
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  VL  HzD-A10

<400>  43

Asp Ile Val Met Thr Gln Ala Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Tyr Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  118
<212>  PRT
<213>  artificial

<220>
<223>  VH  HzD-A10

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Ser Asp Gly Ser Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ile Ala His Tyr Ser Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  45
<211>  354
<212>  DNA
<213>  artificial

<220>
<223>  VH  HzD-A10

<400>  45
gaagtacaat tggtagaatc aggtggtggt ttggttcagc caggaggatc actgagactg       60

tcctgcgctg caagcggctt taccttctct agctactgga tgtcttgggt ccggcaagcc      120

ccagggaagg gactggtgtg ggtgagcgat attaatagtg acggctcttc tactaagtat      180

gctgatagtg tcaagggccg attcaccatc tcacgagaca acgccaagaa caccttgtac      240

ctccagatga actctttgag agctgaggat acagcagtgt attactgtat cgcccactac      300

tcagggggag gctttgctta ctggggtcaa ggcacactcg tgacagtctc ctct            354


<210>  46
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  VL  HzD-A10

<400>  46
gatattgtaa tgactcaagc tccactctcc ttgcctgtaa ctcctggaga gcccgcttct       60

attagctgta ggagtagtaa aagcctgctt tacagtaatg gttacaatta cctgtactgg      120

tttttgcaga agcctggaca gtcaccccag ctcctcatct attatatgtc taacttggcc      180

agtggtgtcc cagaccgttt tagtggcagc ggctcaggca ccgactttac ccttaagatc      240

agccgagtcg aggctgaaga cgtaggagtg tactactgta tgcagagtct tgagtatcca      300

ttcaccttcg ggcagggcac caagctcgaa ataaag                                336


<210>  47
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  CH of chD-A10

<400>  47

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  48
<211>  993
<212>  DNA
<213>  artificial

<220>
<223>  CH of chD-A10

<400>  48
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  49
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  CL of chD-A10

<400>  49

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  50
<211>  324
<212>  DNA
<213>  artificial

<220>
<223>  CL of chD-A10

<400>  50
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324





