               SEQUENCE LISTING

<110> Cantargia AB

<120> Novel Antibodies and Uses Thereof 

<150> GB1413913.3
<151> 2014-08-06

<160> 30

<170> BiSSAP 1.2

<210> 1
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine-derived antibody, CAN01, heavy chain variable region

<400> 1
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Val Ser Ser Tyr 
            20                  25                  30          
Trp Ile Asp Trp Val Lys Gln Thr Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Ser Ala Ile Asn Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Phe Asp Ser Thr Phe Val Tyr Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 2
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine-derived antibody, CAN01, light chain variable region

<400> 2
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 3
Gly Tyr Thr Val Ser Ser Tyr 
1               5           

<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 4
Leu Pro Gly Ser Ala Ile 
1               5       

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 5
Gly Asp Tyr Phe Asp Ser Thr Phe Val Tyr Tyr 
1               5                   10      

<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 6
Gly Tyr Thr Val Ser Ser Tyr Trp Ile Asp 
1               5                   10  

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 7
Glu Ile Leu Pro Gly Ser Ala Ile Asn Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 8
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region

<400> 8
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Val Ser Ser Tyr 
            20                  25                  30          
Trp Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Ser Ala Ile Asn Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Phe Asp Ser Thr Phe Val Tyr Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 9
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region

<400> 9
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Val Ser Ser Tyr 
            20                  25                  30          
Trp Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Ser Ala Ile Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Phe Asp Ser Thr Phe Val Tyr Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 10
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain variable region

<400> 10
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Asp Gly Tyr Thr Val Ser Ser Tyr 
            20                  25                  30          
Trp Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Ser Ala Ile Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Phe Asp Ser Thr Phe Val Tyr Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 11
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 12
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 13
Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   

<210> 14
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region

<400> 14
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 15
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region

<400> 15
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Thr His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 16
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region

<400> 16
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Thr His Ser 
            20                  25                  30          
Asn Gly Gln Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 17
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region

<400> 17
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Thr His Ser 
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 18
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain variable region

<400> 18
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Thr His Ser 
            20                  25                  30          
Ser Gly Gln Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 19
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine derived antibody, CAN03, heavy chain variable region

<400> 19
Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Ile Gly Gly Ser Tyr Ile Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Glu Val Asp Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser 
        115                 

<210> 20
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Murine derived antibody, CAN03, light chain variable region

<400> 20
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          
Ile His Trp Tyr Gln Arg Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Ser Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Thr 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 21
Gly Phe Thr Phe Ser Ile Tyr 
1               5           

<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 22
Ser Ile Gly Gly Ser Tyr 
1               5       

<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 23
Glu Val Asp Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10  

<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 24
Gly Phe Thr Phe Ser Ile Tyr Thr Met Ser 
1               5                   10  

<210> 25
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 25
Thr Ile Ser Ile Gly Gly Ser Tyr Ile Asn Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 26
Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      

<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 27
Ser Ala Ser Glu Ser Ile Ser 
1               5           

<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR

<400> 28
Gln Gln Ser Asn Ser Trp Pro Thr Thr 
1               5                   

<210> 29
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> Ig kappa chain C region

<400> 29
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     

<210> 30
<211> 330
<212> PRT
<213> Homo sapiens

<220> 
<223> Ig gamma-1 chain C region

<400> 30
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

