               SEQUENCE LISTING

<110> AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
      UNIVERSITA' DEGLI STUDI DI FIRENZE

<120> ANTI-hERG1 MOLECULES

<130> 12696PTWO

<150> ITFI2014A000189
<151> 2014-08-08

<160> 17

<170> BiSSAP 1.3

<210> 1
<211> 381
<212> DNA
<213> Mus musculus

<220> 
<223> /note="anti-hERG1 VH"
      /organelle="mitochondrion"

<220> 
<221> CDS
<222> 1..381
<223> /transl_table=2

<400> 1
gag gtc caa ctg caa cag tct gga cct gaa ctg gtg aag cct ggg gct     48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      

tct gtg aag ata tcc tgc aag act tca gga tac aca ttc act gaa tac     96
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          

acc gtt cac tgg gtg aaa cag agc cat gga aag agc ctt gaa tgg att    144
Thr Val His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              

gga ggc att aat cct aat ggt ggt act acc tat aat cag aag ttc aag    192
Gly Gly Ile Asn Pro Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  

ggc aag gcc aca ttg act att gac aag tcc tcc agc tca gcc ttc atg    240
Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Ser Ala Phe Met 
65                  70                  75                  80  

gag ctc cgc agc ctg aca tct gag gat tct gca gtc tat tac ttt gca    288
Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Phe Ala 
                85                  90                  95      

aca ggt tgg gga cct gac tac tgg ggc caa ggc acc act ctc aca gtc    336
Thr Gly Trp Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         

tcc tca gcc aaa aca aca ccc cca tca gtc tat cca ctg gcc cct        381
Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125         

<210> 2
<211> 363
<212> DNA
<213> Mus musculus

<220> 
<223> VL chain

<220> 
<221> CDS
<222> 1..363
<223> /transl_table=1

<400> 2
gat att gtg ctg aca caa tct cca ctc act ttg tcg gtt aac att ggt     48
Asp Ile Val Leu Thr Gln Ser Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      

caa cca gcc tct atc tct tgc aag tca agt cag agc ctc tta tat act     96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          

aat gga aaa acc tat ttt aat tgg tta tta cag agg cca ggc cag tct    144
Asn Gly Lys Thr Tyr Phe Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              

cca aag cgc cta atc tat ctg gtg tct aaa ctg gac tct gga gtc cct    192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  

gac agg ttc act ggc agt gga tca gga aca gat ttt aca ctg aaa atc    240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  

agc aga gtg gag gct gaa gat ttg gga gtt tat tac tgc gcg caa ggt    288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Ala Gln Gly 
                85                  90                  95      

aca cat ttt ccg tgg acg ttc ggt gga ggg acc aag ctg gaa atc aaa    336
Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

cgg gct gat gct gca cca act gta tcc                                363
Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120     

<210> 3
<211> 127
<212> PRT
<213> Mus musculus

<220> 
<223> [CDS]:1..381 from SEQ ID NO 1

<400> 3
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Val His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  
Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Ser Ala Phe Met 
65                  70                  75                  80  
Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Phe Ala 
                85                  90                  95      
Thr Gly Trp Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125         

<210> 4
<211> 121
<212> PRT
<213> Mus musculus

<220> 
<223> [CDS]:1..363 from SEQ ID NO 2

<400> 4
Asp Ile Val Leu Thr Gln Ser Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          
Asn Gly Lys Thr Tyr Phe Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Ala Gln Gly 
                85                  90                  95      
Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120     

<210> 5
<211> 798
<212> DNA
<213> Artificial Sequence

<220> 
<223> scFv-hERG1

<220> 
<221> CDS
<222> 1..798
<223> /note="scFV-hERG1"
      /transl_table=1

<400> 5
gag gtc caa ctg caa cag tct gga cct gaa ctg gtg aag cct ggg gct     48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      

tct gtg aag ata tcc tgc aag act tca gga tac aca ttc act gaa tac     96
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          

acc gtt cac tgg gtg aaa cag agc cat gga aag agc ctt gaa tgg att    144
Thr Val His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              

gga ggc att aat cct aat ggt ggt act acc tat aat cag aag ttc aag    192
Gly Gly Ile Asn Pro Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  

ggc aag gcc aca ttg act att gac aag tcc tcc agc tca gcc ttc atg    240
Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Ser Ala Phe Met 
65                  70                  75                  80  

gag ctc cgc agc ctg aca tct gag gat tct gca gtc tat tac ttt gca    288
Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Phe Ala 
                85                  90                  95      

aca ggt tgg gga cct gac tac tgg ggc caa ggc acc act ctc aca gtc    336
Thr Gly Trp Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         

tcc tca gcc aaa aca aca ccc cca tca gtc tat cca ctg gcc cct ggc    384
Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             

tcg agt ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt agt gca    432
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala 
    130                 135                 140                 

ctg gat att gtg ctg aca caa tct cca ctc act ttg tcg gtt aac att    480
Leu Asp Ile Val Leu Thr Gln Ser Pro Leu Thr Leu Ser Val Asn Ile 
145                 150                 155                 160 

ggt caa cca gcc tct atc tct tgc aag tca agt cag agc ctc tta tat    528
Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr 
                165                 170                 175     

act aat gga aaa acc tat ttt aat tgg tta tta cag agg cca ggc cag    576
Thr Asn Gly Lys Thr Tyr Phe Asn Trp Leu Leu Gln Arg Pro Gly Gln 
            180                 185                 190         

tct cca aag cgc cta atc tat ctg gtg tct aaa ctg gac tct gga gtc    624
Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val 
        195                 200                 205             

cct gac agg ttc act ggc agt gga tca gga aca gat ttt aca ctg aaa    672
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
    210                 215                 220                 

atc agc aga gtg gag gct gaa gat ttg gga gtt tat tac tgc gcg caa    720
Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Ala Gln 
225                 230                 235                 240 

ggt aca cat ttt ccg tgg acg ttc ggt gga ggg acc aag ctg gaa atc    768
Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                245                 250                 255     

aaa cgg gct gat gct gca cca act gta tcc                            798
Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
            260                 265     

<210> 6
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> [CDS]:1..798 from SEQ ID NO 5

<400> 6
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Val His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  
Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Ser Ala Phe Met 
65                  70                  75                  80  
Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Phe Ala 
                85                  90                  95      
Thr Gly Trp Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala 
    130                 135                 140                 
Leu Asp Ile Val Leu Thr Gln Ser Pro Leu Thr Leu Ser Val Asn Ile 
145                 150                 155                 160 
Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr 
                165                 170                 175     
Thr Asn Gly Lys Thr Tyr Phe Asn Trp Leu Leu Gln Arg Pro Gly Gln 
            180                 185                 190         
Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val 
        195                 200                 205             
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
    210                 215                 220                 
Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Ala Gln 
225                 230                 235                 240 
Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                245                 250                 255     
Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
            260                 265     

<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> degKappadir

<400> 7
gayattgtgm tsacmcarwc tmca                                           24


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Kapparev

<400> 8
ggatacagtt ggtgcagcat c                                              21


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> degH2dir

<400> 9
gaggtccarc tgcaacartc                                                20


<210> 10
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2brev

<400> 10
aggggccagt ggatagactg atgg                                           24


<210> 11
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH for Sal I

<400> 11
acgcgtcgac gaggtccaac tgcaacagtc                                     30


<210> 12
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH rev Xho I

<400> 12
ccgctcgagc caggggccag tggatagact gatgg                                35


<210> 13
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL for ApaL I

<400> 13
acgcgtgcac tggatattgt gctgacacaa tctcca                               36


<210> 14
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL rev Not I

<400> 14
ataagaatgc ggccgcggat acagttggtg cagcatc                              37


<210> 15
<211> 1101
<212> DNA
<213> Artificial Sequence

<220> 
<223> scFv-hERG1 expression cassette

<220> 
<221> CDS
<222> 1..1095
<223> /product="expressed protein"
      /transl_table=1

<400> 15
atg aga ttt cct tca att ttt act gca gtt tta ttc gca gca tcc tcc      48
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      

gca tta gct gct cca gtc aac act aca aca gaa gat gaa acg gca caa      96
Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          

att ccg gct gaa gct gtc atc ggt tac tca gat tta gaa ggg gat ttc     144
Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              

gat gtt gct gtt ttg cca ttt tcc aac agc aca aat aac ggg tta ttg     192
Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  

ttt ata aat act act att gcc agc att gct gct aaa gaa gaa ggg gta     240
Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  

tct ctc gag aaa aga gag gct gag gca gag gtc caa ctg caa cag tct     288
Ser Leu Glu Lys Arg Glu Ala Glu Ala Glu Val Gln Leu Gln Gln Ser 
                85                  90                  95      

gga cct gaa ctg gtg aag cct ggg gct tct gtg aag ata tcc tgc aag     336
Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 
            100                 105                 110         

act tca gga tac aca ttc act gaa tac acc gtt cac tgg gtg aaa cag     384
Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Val His Trp Val Lys Gln 
        115                 120                 125             

agc cat gga aag agc ctt gaa tgg att gga ggc att aat cct aat ggt     432
Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Gly 
    130                 135                 140                 

ggt act acc tat aat cag aag ttc aag ggc aag gcc aca ttg act att     480
Gly Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ile 
145                 150                 155                 160 

gac aag tcc tcc agc tca gcc ttc atg gag ctc cgc agc ctg aca tct     528
Asp Lys Ser Ser Ser Ser Ala Phe Met Glu Leu Arg Ser Leu Thr Ser 
                165                 170                 175     

gag gat tct gca gtc tat tac ttt gca aca ggt tgg gga cct gac tac     576
Glu Asp Ser Ala Val Tyr Tyr Phe Ala Thr Gly Trp Gly Pro Asp Tyr 
            180                 185                 190         

tgg ggc caa ggc acc act ctc aca gtc tcc tca gcc aaa aca aca ccc     624
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 
        195                 200                 205             

cca tca gtc tat cca ctg gcc cct ggc tcg agt ggt gga ggc ggt tca     672
Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 

ggc gga ggt ggc tct ggc ggt agt gca ctg gat att gtg ctg aca caa     720
Gly Gly Gly Gly Ser Gly Gly Ser Ala Leu Asp Ile Val Leu Thr Gln 
225                 230                 235                 240 

tct cca ctc act ttg tcg gtt aac att ggt caa cca gcc tct atc tct     768
Ser Pro Leu Thr Leu Ser Val Asn Ile Gly Gln Pro Ala Ser Ile Ser 
                245                 250                 255     

tgc aag tca agt cag agc ctc tta tat act aat gga aaa acc tat ttt     816
Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr Asn Gly Lys Thr Tyr Phe 
            260                 265                 270         

aat tgg tta tta cag agg cca ggc cag tct cca aag cgc cta atc tat     864
Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
        275                 280                 285             

ctg gtg tct aaa ctg gac tct gga gtc cct gac agg ttc act ggc agt     912
Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
    290                 295                 300                 

gga tca gga aca gat ttt aca ctg aaa atc agc aga gtg gag gct gaa     960
Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
305                 310                 315                 320 

gat ttg gga gtt tat tac tgc gcg caa ggt aca cat ttt ccg tgg acg    1008
Asp Leu Gly Val Tyr Tyr Cys Ala Gln Gly Thr His Phe Pro Trp Thr 
                325                 330                 335     

ttc ggt gga ggg acc aag ctg gaa atc aaa cgg gct gat gct gca cca    1056
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            340                 345                 350         

act gta tcc cct agg cat cat cac cat cac cat cat cac taatag         1101
Thr Val Ser Pro Arg His His His His His His His His       
        355                 360                 365       

<210> 16
<211> 365
<212> PRT
<213> Artificial Sequence

<220> 
<223> [CDS]:1..1095 from SEQ ID NO 15

<400> 16
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      
Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          
Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              
Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  
Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  
Ser Leu Glu Lys Arg Glu Ala Glu Ala Glu Val Gln Leu Gln Gln Ser 
                85                  90                  95      
Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 
            100                 105                 110         
Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Val His Trp Val Lys Gln 
        115                 120                 125             
Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Gly 
    130                 135                 140                 
Gly Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ile 
145                 150                 155                 160 
Asp Lys Ser Ser Ser Ser Ala Phe Met Glu Leu Arg Ser Leu Thr Ser 
                165                 170                 175     
Glu Asp Ser Ala Val Tyr Tyr Phe Ala Thr Gly Trp Gly Pro Asp Tyr 
            180                 185                 190         
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 
        195                 200                 205             
Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Gly Gly Gly Gly Ser Gly Gly Ser Ala Leu Asp Ile Val Leu Thr Gln 
225                 230                 235                 240 
Ser Pro Leu Thr Leu Ser Val Asn Ile Gly Gln Pro Ala Ser Ile Ser 
                245                 250                 255     
Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr Asn Gly Lys Thr Tyr Phe 
            260                 265                 270         
Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
        275                 280                 285             
Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
    290                 295                 300                 
Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
305                 310                 315                 320 
Asp Leu Gly Val Tyr Tyr Cys Ala Gln Gly Thr His Phe Pro Trp Thr 
                325                 330                 335     
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            340                 345                 350         
Thr Val Ser Pro Arg His His His His His His His His 
        355                 360                 365 

<210> 17
<211> 280
<212> PRT
<213> Artificial Sequence

<220> 
<223> secreted scFv-hERG1-6xHis

<400> 17
Glu Ala Glu Ala Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
1               5                   10                  15      
Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 
            20                  25                  30          
Phe Thr Glu Tyr Thr Val His Trp Val Lys Gln Ser His Gly Lys Ser 
        35                  40                  45              
Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Gly Gly Thr Thr Tyr Asn 
    50                  55                  60                  
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser 
65                  70                  75                  80  
Ser Ala Phe Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
                85                  90                  95      
Tyr Tyr Phe Ala Thr Gly Trp Gly Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             
Leu Ala Pro Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Ser Ala Leu Asp Ile Val Leu Thr Gln Ser Pro Leu Thr Leu 
145                 150                 155                 160 
Ser Val Asn Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
                165                 170                 175     
Ser Leu Leu Tyr Thr Asn Gly Lys Thr Tyr Phe Asn Trp Leu Leu Gln 
            180                 185                 190         
Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu 
        195                 200                 205             
Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 
Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 
Tyr Cys Ala Gln Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     
Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Pro Arg 
            260                 265                 270         
His His His His His His His His 
        275                 280 

