                         SEQUENCE LISTING

<110>  Voerman, Gerard
 
<120>  Mutants of leech derived neutrophil elastase inhibitors and uses 
       thereof.

<130>  P107199PC00

<150>  PCT/EP2014/066844
<151>  2014-08-05

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Cys Xaa Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Cys Xaa Cys Xaa Xaa Xaa Xaa Cys Leu Xaa Xaa Xaa Cys Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Asp Xaa Asn Gly Cys Xaa Xaa Xaa Cys Xaa Cys 
        35                  40                  45      


<210>  2
<211>  57
<212>  PRT
<213>  Hirudo nipponia

<400>  2

Val Asp Glu Asn Ala Glu Asp Thr His Gly Leu Cys Gly Glu Lys Thr 
1               5                   10                  15      


Cys Ser Pro Ala Gln Val Cys Leu Asn Asn Glu Cys Ala Cys Thr Ala 
            20                  25                  30          


Ile Arg Cys Met Ile Phe Cys Pro Asn Gly Phe Lys Val Asp Glu Asn 
        35                  40                  45              


Gly Cys Glu Tyr Pro Cys Thr Cys Ala 
    50                  55          


<210>  3
<211>  48
<212>  PRT
<213>  Hirudo nipponia

<400>  3

Thr Asp Cys Gly Gly Lys Thr Cys Ser Glu Ala Gln Val Cys Lys Asp 
1               5                   10                  15      


Gly Lys Cys Val Cys Val Ile Gly Gln Cys Arg Lys Tyr Cys Pro Asn 
            20                  25                  30          


Gly Phe Lys Lys Asp Glu Asn Gly Cys Thr Phe Pro Cys Thr Cys Ala 
        35                  40                  45              


<210>  4
<211>  55
<212>  PRT
<213>  Hirudo medicinalis

<400>  4

Thr Gln Gly Asn Thr Cys Gly Gly Glu Thr Cys Ser Ala Ala Gln Val 
1               5                   10                  15      


Cys Leu Lys Gly Lys Cys Val Cys Asn Glu Val His Cys Arg Ile Arg 
            20                  25                  30          


Cys Lys Tyr Gly Leu Lys Lys Asp Glu Asn Gly Cys Glu Tyr Pro Cys 
        35                  40                  45              


Ser Cys Ala Lys Ala Ser Gln 
    50                  55  


<210>  5
<211>  59
<212>  PRT
<213>  Hirudo medicinalis

<400>  5

Phe Asp Val Asn Ser His Thr Thr Pro Cys Gly Pro Val Thr Cys Ser 
1               5                   10                  15      


Gly Ala Gln Met Cys Glu Val Asp Lys Cys Val Cys Ser Asp Leu His 
            20                  25                  30          


Cys Lys Val Lys Cys Glu His Gly Phe Lys Lys Asp Asp Asn Gly Cys 
        35                  40                  45              


Glu Tyr Ala Cys Ile Cys Ala Asp Ala Pro Gln 
    50                  55                  


<210>  6
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fahsin-Ile

<400>  6

Asp Asp Asn Cys Gly Gly Lys Val Cys Ser Lys Gly Gln Leu Cys His 
1               5                   10                  15      


Asp Gly His Cys Glu Cys Thr Pro Ile Arg Cys Ile Ile Phe Cys Pro 
            20                  25                  30          


Asn Gly Phe Ala Val Asp Glu Asn Gly Cys Glu Leu Pro Cys Ser Cys 
        35                  40                  45              


Lys His Gln 
    50      


<210>  7
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  guamerin-Leu

<400>  7

Val Asp Glu Asn Ala Glu Asp Thr His Gly Leu Cys Gly Glu Lys Thr 
1               5                   10                  15      


Cys Ser Pro Ala Gln Val Cys Leu Asn Asn Glu Cys Ala Cys Thr Ala 
            20                  25                  30          


Ile Arg Cys Leu Ile Phe Cys Pro Asn Gly Phe Lys Val Asp Glu Asn 
        35                  40                  45              


Gly Cys Glu Tyr Pro Cys Thr Cys Ala 
    50                  55          


<210>  8
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for overlap extension

<400>  8
ggggtatctc tcgagaaaag agacgacaac tgtggtggta aggtttgttc taagggtcaa       60


<210>  9
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for overlap extension

<400>  9
aatcaaacat ctaattgagt acactcacag tgaccggtcg tgacacaatt gacccttaga       60

acaaac                                                                  66


<210>  10
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for overlap extension

<400>  10
ccaattagat gtttgatttt ctgtccaaac ggtttcgctg ttgacgagaa cggttgtgag       60


<210>  11
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for overlap extension

<400>  11
gctggcggcc gctcattggt gcttacaaga acatggcaac tcacaaccgt tctcgtc          57


<210>  12
<211>  156
<212>  DNA
<213>  Limnatis nilotica


<220>
<221>  CDS
<222>  (1)..(156)

<400>  12
gac gac aac tgt ggt ggt aag gtt tgt tct aag ggt caa ttg tgt cac         48
Asp Asp Asn Cys Gly Gly Lys Val Cys Ser Lys Gly Gln Leu Cys His           
1               5                   10                  15                

gac ggt cac tgt gag tgt act cca att aga tgt ttg att ttc tgt cca         96
Asp Gly His Cys Glu Cys Thr Pro Ile Arg Cys Leu Ile Phe Cys Pro           
            20                  25                  30                    

aac ggt ttc gct gtt gac gag aac ggt tgt gag ttg cca tgt tct tgt        144
Asn Gly Phe Ala Val Asp Glu Asn Gly Cys Glu Leu Pro Cys Ser Cys           
        35                  40                  45                        

aag cac caa tga                                                        156
Lys His Gln                                                               
    50                                                                    


<210>  13
<211>  51
<212>  PRT
<213>  Limnatis nilotica

<400>  13

Asp Asp Asn Cys Gly Gly Lys Val Cys Ser Lys Gly Gln Leu Cys His 
1               5                   10                  15      


Asp Gly His Cys Glu Cys Thr Pro Ile Arg Cys Leu Ile Phe Cys Pro 
            20                  25                  30          


Asn Gly Phe Ala Val Asp Glu Asn Gly Cys Glu Leu Pro Cys Ser Cys 
        35                  40                  45              


Lys His Gln 
    50      


