б
<110>  ＼޹˾
<120>  ԭԿTNF-ȫԴӦ
<130>  KHP153811354
<160>  24    
<170>  PatentIn version 3.5

<210>  1
<211>  714
<212>  DNA
<213>  ĽͰľɱL1
<400>  1
atggacatga gggtccctgc tcagctcctg ggactcctgc tgctctggct cccagatacc       60
agatgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120
gtcaccatca cttgccgggc gagtcagggc attaggaatt atttagcctg gtatcagcag      180
aaaccaggga aagctcctaa actcctgatc tatgctgcat ccactttgca atcaggggtc      240
ccatctcggt tcagcggcag tggatctggg acaggtttca ctctcaccat cagcagcctg      300
cagcctgaag atgttgcaac ttattactgt caaaggtata acagagcccc gtacactttt      360
ggccagggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420
ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600
ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660
cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtaa            714

<210>  2
<211>  714
<212>  DNA
<213>  ĽͰľɱL2
<400>  2
atggacatga gggtccctgc tcagctcctg ggactcctgc tgctctggct cccagatacc       60
agatgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120
gtcaccatca cttgccgggc gagtcagggc attaggaatt atttagcctg gtatcagcag      180
aaaccaggga aagctcctaa actcctgatc tatgctgcat ccactttgca atcaggggtc      240
ccatctcggt tcagcggcag tggatctggg acaggtttca ctctcaccat cagcagcctg      300
cagcctgaag attttgcaac ttattactgt caaaggtata acagagcccc gtacactttt      360
ggccagggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420
ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600
ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660
cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtaa            714

<210>  3
<211>  714
<212>  DNA
<213>  ĽͰľɱL3
<400>  3
atggacatga gggtccctgc tcagctcctg ggactcctgc tgctctggct cccagatacc       60
agatgtgaca tccagatgac ccagtctcca tcctccgtgt ctgcatctgt aggagacaga      120
gtcaccatca cttgccgggc gagtcagggc attaggaatt atttagcctg gtatcagcag      180
aaaccaggga aagctcctaa actcctgatc tatgctgcat ccactttgca atcaggggtc      240
ccatctcggt tcagcggcag tggatctggg acaggtttca ctctcaccat cagcagcctg      300
cagcctgaag atgttgcaac ttattactgt caaaggtata acagagcccc gtacactttt      360
ggccagggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420
ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600
ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660
cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtaa            714

<210>  4
<211>  714
<212>  DNA
<213>  ĽͰľɱL4
<400>  4
atggacatga gggtccctgc tcagctcctg ggactcctgc tgctctggct cccagatacc       60
agatgtgaca tccagatgac ccagtctcca tcctccgtgt ctgcatctgt aggagacaga      120
gtcaccatca cttgccgggc gagtcagggc attaggaatt atttagcctg gtatcagcag      180
aaaccaggga aagctcctaa actcctgatc tatgctgcat ccactttgca atcaggggtc      240
ccatctcggt tcagcggcag tggatctggg acaggtttca ctctcaccat cagcagcctg      300
cagcctgaag attttgcaac ttattactgt caaaggtata acagagcccc gtacactttt      360
ggccagggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420
ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600
ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660
cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtaa            714

<210>  5
<211>  714
<212>  DNA
<213>  ĽͰľɱL5
<400>  5
atggacatga gggtccctgc tcagctcctg ggactcctgc tgctctggct cccagatacc       60
agatgtgaca tccagatgac ccagtctcca tcctccgtgt ctgcatctgt aggagacaga      120
gtcaccatca cttgccgggc gagtcagggc attaggaatt atttagcctg gtatcagcag      180
aaaccaggga aagtgcctgt actcctgatc tatgctgcat ccactttgca atcaggggtc      240
ccatctcggt tcagcggcag tggatctggg acaggtttca ctctcaccat cagcagcctg      300
cagcctgaag atgttgcaac ttattactgt caaaggtata acagagcccc gtacactttt      360
ggccagggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420
ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600
ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660
cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtaa            714

<210>  6
<211>  522
<212>  DNA
<213>  ĽͰľɱh1
<400>  6
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgag       60
gtgcagctgg tggagtctgg gggaggcttg gtacagcccg gcaggtccct gagactctcc      120
tgtgcggcct ctggattcac ctttgatgat tatgccatgc actgggtccg gcaagctcca      180
gggaagggcc tggaatgggt ctcagctatc acttggaata gtggtcacat agactatgcg      240
gactctgtgg agggccgatt caccatctcc ctggacacct ccaagtccac cgcttatctg      300
caaatgaaca gtctgagagc tgaggattca gccgtatatt actgtgcgaa agtctcgtac      360
cttagcaccg cgtcctccct tgactattgg ggccaaggaa ccctggtcac cgtctcgagt      420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480
ggcacagcag ccctgggctg cctggtcaag gactacttcc cc                         522

<210>  7
<211>  522
<212>  DNA
<213>  ĽͰľɱh2
<400>  7
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgag       60
gtgcagctgg tggagtctgg gggaggcttg gtacagcccg gcaggtccct gagactctcc      120
tgtgcggcct ctggattcac ctttgatgat tatgccatgc actgggtccg gcaagctcca      180
gggaagggcc tggaatgggt ctcagctatc acttggaata gtggtcacat agactatgcg      240
gactctgtgg agggccgatt caccttctcc ctggacacct ccaagtccac cgcttatctg      300
caaatgaaca gtctgagagc tgaggatacg gccgtatatt actgtgcgaa agtctcgtac      360
cttagcaccg cgtcctccct tgactattgg ggccaaggaa ccctggtcac cgtctcgagt      420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480
ggcacagcag ccctgggctg cctggtcaag gactacttcc cc                         522

<210>  8
<211>  522
<212>  DNA
<213>  ĽͰľɱh3
<400>  8
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgag       60
gtgcagctgg tggagtctgg gggaggcttg gtacagcccg gcggatccct gagactctcc      120
tgtgcggcct ctggatacac ctttgatgat tatgccatgc actgggtccg gcaagctcca      180
gggaagggcc tggaatgggt ctcagctatc acttggaata gtggtcacat agactatgcg      240
gactctgtgg agggccgatt caccatctcc ctggacacct ccaagtccac cgcttatctg      300
caaatgaaca gtctgagagc tgaggattca gccgtatatt actgtgcgaa agtctcgtac      360
cttagcaccg cgtcctccct tgactattgg ggccaaggaa ccctggtcac cgtctcgagt      420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480
ggcacagcag ccctgggctg cctggtcaag gactacttcc cc                         522

<210>  9
<211>  522
<212>  DNA
<213>  ĽͰľɱh4
<400>  9
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgag       60
gtgcagctgg tggagtctgg gggaggcttg gtacagcccg gcggatccct gagactctcc      120
tgtgcggcct ctggatacac ctttgatgat tatgccatgc actgggtccg gcaagctcca      180
gggaagggcc tggaatgggt ctcagctatc acttggaata gtggtcacat agactatgcg      240
gactctgtgg agggccgatt caccttctcc ctggacacct ccaagtccac cgcttatctg      300
caaatgaaca gtctgagagc tgaggatacg gccgtatatt actgtgcgaa agtctcgtac      360
cttagcaccg cgtcctccct tgactattgg ggccaaggaa ccctggtcac cgtctcgagt      420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480
ggcacagcag ccctgggctg cctggtcaag gactacttcc cc                         522

<210>  10
<211>  522
<212>  DNA
<213>  ĽͰľɱh5
<400>  10
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgag       60
gtgcagctgg tggagtctgg gggaggcttg gtacagcccg gcggatccct gagactctcc      120
tgtgcggcct ctggatacac ctttgatgat tatgccatgc actgggtccg gcaagctcca      180
gggaagggcc tggaatgggt ctcagctatc acttggaata gtggtcacat agactatgcg      240
gactctgtgg agggccgatt caccatctcc ctggacacct ccgtatccac cgcttatctg      300
caaatgaaca gtctgagagc tgaggattca gccgtatatt actgtgcgaa agtctcgtac      360
cttagcaccg cgtcctccct tgactattgg ggccaaggaa ccctggtcac cgtctcgagt      420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480
ggcacagcag ccctgggctg cctggtcaag gactacttcc cc                         522

<210>  11
<211>  236
<212>  PRT
<213> ĽͰľɱL1
<400>  11
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         
Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     

<210>  12
<211>  236
<212>  PRT
<213>  ĽͰľɱL2
<400>  12
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         
Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     

<210>  13
<211>  236
<212>  PRT
<213>  ĽͰľɱL3
<400>  13
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         
Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     

<210>  4
<211>  236
<212>  PRT
<213>  ĽͰľɱL4
<400>  4
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         
Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     

<210>  15
<211>  236
<212>  PRT
<213>  ĽͰľɱL5
<400>  15
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          
Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Val Pro Val Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         
Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     
<210>  16
<211>  174
<212>  PRT
<213>  ĽͰľɱh1
<400>  16
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Leu Asp Thr Ser Lys Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 

<210>  17
<211>  174
<212>  PRT
<213>  ĽͰľɱh2
<400>  17
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Glu Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 

<210>  18
<211>  174
<212>  PRT
<213>  ĽͰľɱh3
<400>  18
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Leu Asp Thr Ser Lys Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 

<210>  19
<211>  174
<212>  PRT
<213>  ĽͰľɱh4

<400>  19

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Glu Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 

<210>  20
<211>  174
<212>  PRT
<213>  ĽͰľɱh5
<400>  20
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Leu Asp Thr Ser Val Ser 
                85                  90                  95      
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 

<210>  21
<211>  714
<212>  DNA
<213>  ԭʼľɱL0
<400>  21
atggacatga gggtccctgc tcagctcctg ggactcctgc tgctctggct cccagatacc       60
agatgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120
gtcaccatca cttgccgggc gagtcagggc attaggaatt atttagcctg gtatcagcag      180
aaaccaggga aagctcctaa actcctgatc tatgctgcat ccactttgca atcaggggtc      240
ccatctcggt tcagcggcag tggatctggg acagatttca ctctcaccat cagcagcctg      300
cagcctgaag atgttgcaac ttattactgt caaaggtata acagagcccc gtacactttt      360
ggccagggga ccaaggtgga gatcaaacga actgtggctg caccatctgt cttcatcttc      420
ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480
ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540
tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600
ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660
cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtaa            714

<210>  22
<211>  522
<212>  DNA
<213>  ԭʼľɱh0
<400>  22
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgtgag       60
gtgcagctgg tggagtctgg gggaggcttg gtacagcccg gcaggtccct gagactctcc      120
tgtgcggcct ctggattcac ctttgatgat tatgccatgc actgggtccg gcaagctcca      180
gggaagggcc tggaatgggt ctcagctatc acttggaata gtggtcacat agactatgcg      240
gactctgtgg agggccgatt caccatctcc agagacaacg ccaagaactc cctgtatctg      300
caaatgaaca gtctgagagc tgaggatacg gccgtatatt actgtgcgaa agtctcgtac      360
cttagcaccg cgtcctccct tgactattgg ggccaaggaa ccctggtcac cgtctcgagt      420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480
ggcacagcag ccctgggctg cctggtcaag gactacttcc cc                         522

<210>  23
<211>  236
<212>  PRT
<213>  ԭʼľɱL0
<400>  23
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              
Gln Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg 
            100                 105                 110         
Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     

<210>  24
<211>  174
<212>  PRT
<213>  ԭʼľɱh0
<400>  24
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala 
65                  70                  75                  80  
Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 

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