                         SEQUENCE LISTING

<110>  SALAMEH, AHMAD
       LEE, ALESSANDRO
       NUNES, DIANA N.
       DIAS-NETO, EMMANUEL
       PASQUALINI, RENATA
       ARAP, WADIH
 
<120>  METHODS FOR THE DETECTION AND TREATMENT OF PROSTATE CANCER

<130>  STCU.P0002WO

<140>  NOT YET ASSIGNED
<141>  2015-07-31

<150>  62/032,103
<151>  2014-08-01

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  3057
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Phe Leu Gln Arg Ala Lys Ser Lys Leu Asn Arg Ser Lys 
1               5                   10                  15      


Arg Leu Glu Lys Val His Val Val Ile Gly Pro Lys Ser Cys Asp Leu 
            20                  25                  30          


Asp Ser Leu Ile Ser Thr Phe Thr Tyr Ala Tyr Phe Leu Asp Lys Val 
        35                  40                  45              


Ser Pro Pro Gly Val Leu Cys Leu Pro Val Leu Asn Ile Pro Arg Thr 
    50                  55                  60                  


Glu Phe Asn Tyr Phe Thr Glu Thr Arg Phe Ile Leu Glu Glu Leu Asn 
65                  70                  75                  80  


Ile Ser Glu Ser Phe His Ile Phe Arg Asp Gly Ile Asn Leu His Gln 
                85                  90                  95      


Leu Asn Asp Glu Gly Lys Leu Ser Ile Thr Leu Val Gly Ser Ser Val 
            100                 105                 110         


Leu Ala Ser Glu Asp Lys Thr Leu Glu Ser Ala Val Val Lys Val Ile 
        115                 120                 125             


Asn Pro Val Glu Gln Ser Asp Ala Asn Val Glu Phe Arg Glu Ser Ser 
    130                 135                 140                 


Ser Ser Leu Val Leu Lys Glu Ile Leu Gln Glu Ala Pro Glu Leu Ile 
145                 150                 155                 160 


Thr Glu Gln Leu Ala His Arg Leu Arg Gly Ser Ile Leu Phe Lys Trp 
                165                 170                 175     


Met Thr Met Glu Ser Glu Lys Ile Ser Glu Lys Gln Glu Glu Ile Leu 
            180                 185                 190         


Ser Ile Leu Glu Glu Lys Phe Pro Asn Leu Pro Pro Arg Glu Asp Ile 
        195                 200                 205             


Ile Asn Val Leu Gln Glu Thr Gln Phe Ser Ala Gln Gly Leu Ser Ile 
    210                 215                 220                 


Glu Gln Thr Met Leu Lys Asp Leu Lys Glu Leu Ser Asp Gly Glu Ile 
225                 230                 235                 240 


Lys Val Ala Ile Ser Thr Val Asn Met Asn Leu Glu Asn Cys Leu Phe 
                245                 250                 255     


His Ser Asn Ile Thr Ser Asp Leu Lys Ala Phe Thr Asp Lys Phe Gly 
            260                 265                 270         


Phe Asp Val Leu Ile Leu Phe Ser Ser Tyr Leu Ser Glu Glu Gln Gln 
        275                 280                 285             


Pro Arg Arg Gln Ile Ala Val Tyr Ser Glu Asn Met Glu Leu Cys Ser 
    290                 295                 300                 


Gln Ile Cys Cys Glu Leu Glu Glu Cys Gln Asn Pro Cys Leu Glu Leu 
305                 310                 315                 320 


Glu Pro Phe Asp Cys Gly Cys Asp Glu Ile Leu Val Tyr Gln Gln Glu 
                325                 330                 335     


Asp Pro Ser Val Thr Cys Asp Gln Val Val Leu Val Val Lys Glu Val 
            340                 345                 350         


Ile Asn Arg Arg Cys Pro Glu Met Val Ser Asn Ser Arg Thr Ser Ser 
        355                 360                 365             


Thr Glu Ala Val Ala Gly Ser Ala Pro Leu Ser Gln Gly Ser Ser Gly 
    370                 375                 380                 


Ile Met Glu Leu Tyr Gly Ser Asp Ile Glu Pro Gln Pro Ser Ser Val 
385                 390                 395                 400 


Asn Phe Ile Glu Asn Pro Pro Asp Leu Asn Asp Ser Asn Gln Ala Gln 
                405                 410                 415     


Val Asp Ala Asn Val Asp Leu Val Ser Pro Asp Ser Gly Leu Ala Thr 
            420                 425                 430         


Ile Arg Ser Ser Arg Ser Ser Lys Glu Ser Ser Val Phe Leu Ser Asp 
        435                 440                 445             


Asp Ser Pro Val Gly Glu Gly Ala Gly Pro His His Thr Leu Leu Pro 
    450                 455                 460                 


Gly Leu Asp Ser Tyr Ser Pro Ile Pro Glu Gly Ala Val Ala Glu Glu 
465                 470                 475                 480 


His Ala Trp Ser Gly Glu His Gly Glu His Phe Asp Leu Phe Asn Phe 
                485                 490                 495     


Asp Pro Ala Pro Met Ala Ser Gly Gln Ser Gln Gln Ser Ser His Ser 
            500                 505                 510         


Ala Asp Tyr Ser Pro Ala Asp Asp Phe Phe Pro Asn Ser Asp Leu Ser 
        515                 520                 525             


Glu Gly Gln Leu Pro Ala Gly Pro Glu Gly Leu Asp Gly Met Gly Thr 
    530                 535                 540                 


Asn Met Ser Asn Tyr Ser Ser Ser Ser Leu Leu Ser Gly Ala Gly Lys 
545                 550                 555                 560 


Asp Ser Leu Val Glu His Asp Glu Glu Phe Val Gln Arg Gln Asp Ser 
                565                 570                 575     


Pro Arg Asp Asn Ser Glu Arg Asn Leu Ser Leu Thr Asp Phe Val Gly 
            580                 585                 590         


Asp Glu Ser Pro Ser Pro Glu Arg Leu Lys Asn Thr Gly Lys Arg Ile 
        595                 600                 605             


Pro Pro Thr Pro Met Asn Ser Leu Val Glu Ser Ser Pro Ser Thr Glu 
    610                 615                 620                 


Glu Pro Ala Ser Leu Tyr Thr Glu Asp Met Thr Gln Lys Ala Thr Asp 
625                 630                 635                 640 


Thr Gly His Met Gly Pro Pro Gln Thr His Ala Arg Cys Ser Ser Trp 
                645                 650                 655     


Trp Gly Gly Leu Glu Ile Asp Ser Lys Asn Ile Ala Asp Ala Trp Ser 
            660                 665                 670         


Ser Ser Glu Gln Glu Ser Val Phe Gln Ser Pro Glu Ser Trp Lys Glu 
        675                 680                 685             


His Lys Pro Ser Ser Ile Asp Arg Arg Ala Ser Asp Ser Val Phe Gln 
    690                 695                 700                 


Pro Lys Ser Leu Glu Phe Thr Lys Ser Gly Pro Trp Glu Ser Glu Phe 
705                 710                 715                 720 


Gly Gln Pro Glu Leu Gly Ser Asn Asp Ile Gln Asp Lys Asn Glu Glu 
                725                 730                 735     


Ser Leu Pro Phe Gln Asn Leu Pro Ile Glu Lys Ser Pro Leu Pro Asn 
            740                 745                 750         


Thr Ser Pro Gln Gly Thr Asn His Leu Ile Glu Asp Phe Ala Ser Leu 
        755                 760                 765             


Trp His Ser Gly Arg Ser Pro Thr Ala Met Pro Glu Pro Trp Gly Asn 
    770                 775                 780                 


Pro Thr Asp Asp Gly Glu Pro Ala Ala Val Ala Pro Phe Pro Ala Trp 
785                 790                 795                 800 


Ser Ala Phe Gly Lys Glu Asp His Asp Glu Ala Leu Lys Asn Thr Trp 
                805                 810                 815     


Asn Leu His Pro Thr Ser Ser Lys Thr Pro Ser Val Arg Asp Pro Asn 
            820                 825                 830         


Glu Trp Ala Met Ala Lys Ser Gly Phe Ala Phe Ser Ser Ser Glu Leu 
        835                 840                 845             


Leu Asp Asn Ser Pro Ser Glu Ile Asn Asn Glu Ala Ala Pro Glu Ile 
    850                 855                 860                 


Trp Gly Lys Lys Asn Asn Asp Ser Arg Asp His Ile Phe Ala Pro Gly 
865                 870                 875                 880 


Asn Pro Ser Ser Asp Leu Asp His Thr Trp Thr Asn Ser Lys Pro Pro 
                885                 890                 895     


Lys Glu Asp Gln Asn Gly Leu Val Asp Pro Lys Thr Arg Gly Lys Val 
            900                 905                 910         


Tyr Glu Lys Val Asp Ser Trp Asn Leu Phe Glu Glu Asn Met Lys Lys 
        915                 920                 925             


Gly Gly Ser Asp Val Leu Val Pro Trp Glu Asp Ser Phe Leu Ser Tyr 
    930                 935                 940                 


Lys Cys Ser Asp Tyr Ser Ala Ser Asn Leu Gly Glu Asp Ser Val Pro 
945                 950                 955                 960 


Ser Pro Leu Asp Thr Asn Tyr Ser Thr Ser Asp Ser Tyr Thr Ser Pro 
                965                 970                 975     


Thr Phe Ala Gly Asp Glu Lys Glu Thr Glu His Lys Pro Phe Ala Lys 
            980                 985                 990         


Glu Glu Gly Phe Glu Ser Lys Asp  Gly Asn Ser Thr Ala  Glu Glu Thr 
        995                 1000                 1005             


Asp Ile  Pro Pro Gln Ser Leu  Gln Gln Ser Ser Arg  Asn Arg Ile 
    1010                 1015                 1020             


Ser Ser  Gly Pro Gly Asn Leu  Asp Met Trp Ala Ser  Pro His Thr 
    1025                 1030                 1035             


Asp Asn  Ser Ser Glu Ile Asn  Thr Thr His Asn Leu  Asp Glu Asn 
    1040                 1045                 1050             


Glu Leu  Lys Thr Glu His Thr  Asp Gly Lys Asn Ile  Ser Met Glu 
    1055                 1060                 1065             


Asp Asp  Val Gly Glu Ser Ser  Gln Ser Ser Tyr Asp  Asp Pro Ser 
    1070                 1075                 1080             


Met Met  Gln Leu Tyr Asn Glu  Thr Asn Arg Gln Leu  Thr Leu Leu 
    1085                 1090                 1095             


His Ser  Ser Thr Asn Ser Arg  Gln Thr Ala Pro Asp  Ser Leu Asp 
    1100                 1105                 1110             


Leu Trp  Asn Arg Val Ile Leu  Glu Asp Thr Gln Ser  Thr Ala Thr 
    1115                 1120                 1125             


Ile Ser  Asp Met Asp Asn Asp  Leu Asp Trp Asp Asp  Cys Ser Gly 
    1130                 1135                 1140             


Gly Ala  Ala Ile Pro Ser Asp  Gly Gln Thr Glu Gly  Tyr Met Ala 
    1145                 1150                 1155             


Glu Gly  Ser Glu Pro Glu Thr  Arg Phe Thr Val Arg  Gln Leu Glu 
    1160                 1165                 1170             


Pro Trp  Gly Leu Glu Tyr Gln  Glu Ala Asn Gln Val  Asp Trp Glu 
    1175                 1180                 1185             


Leu Pro  Ala Ser Asp Glu His  Thr Lys Asp Ser Ala  Pro Ser Glu 
    1190                 1195                 1200             


His His  Thr Leu Asn Glu Lys  Ser Gly Gln Leu Ile  Ala Asn Ser 
    1205                 1210                 1215             


Ile Trp  Asp Ser Val Met Arg  Asp Lys Asp Met Ser  Ser Phe Met 
    1220                 1225                 1230             


Leu Pro  Gly Ser Ser His Ile  Thr Asp Ser Glu Gln  Arg Glu Leu 
    1235                 1240                 1245             


Pro Pro  Glu Ile Pro Ser His  Ser Ala Asn Val Lys  Asp Thr His 
    1250                 1255                 1260             


Phe Pro  Asp Ala Pro Ala Ala  Ser Gly Thr Ser Glu  Ser Glu Ala 
    1265                 1270                 1275             


Leu Ile  Ser His Leu Asp Lys  Gln Asp Thr Glu Arg  Glu Thr Leu 
    1280                 1285                 1290             


Gln Ser  Asp Ala Ala Ser Leu  Ala Thr Arg Leu Glu  Asn Pro Gly 
    1295                 1300                 1305             


Tyr Phe  Pro His Pro Asp Pro  Trp Lys Gly His Gly  Asp Gly Gln 
    1310                 1315                 1320             


Ser Glu  Ser Glu Lys Glu Ala  Gln Gly Ala Thr Asp  Arg Gly His 
    1325                 1330                 1335             


Leu Asp  Glu Glu Glu Val Ile  Ala Ser Gly Val Glu  Asn Ala Ser 
    1340                 1345                 1350             


Gly Ile  Ser Glu Lys Gly Gln  Ser Asp Gln Glu Leu  Ser Ser Leu 
    1355                 1360                 1365             


Val Ala  Ser Glu His Gln Glu  Ile Cys Ile Lys Ser  Gly Lys Ile 
    1370                 1375                 1380             


Ser Ser  Leu Ala Val Thr Phe  Ser Pro Gln Thr Glu  Glu Pro Glu 
    1385                 1390                 1395             


Glu Val  Leu Glu Tyr Glu Glu  Gly Ser Tyr Asn Leu  Asp Ser Arg 
    1400                 1405                 1410             


Asp Val  Gln Thr Gly Met Ser  Ala Asp Asn Leu Gln  Pro Lys Asp 
    1415                 1420                 1425             


Thr His  Glu Lys His Leu Met  Ser Gln Arg Asn Ser  Gly Glu Thr 
    1430                 1435                 1440             


Thr Glu  Thr Ser Asp Gly Met  Asn Phe Thr Lys Tyr  Val Ser Val 
    1445                 1450                 1455             


Pro Glu  Lys Asp Leu Glu Lys  Thr Glu Glu Cys Asn  Phe Leu Glu 
    1460                 1465                 1470             


Pro Glu  Asn Val Gly Gly Gly  Pro Pro His Arg Val  Pro Arg Ser 
    1475                 1480                 1485             


Leu Asp  Phe Gly Asp Val Pro  Ile Asp Ser Asp Val  His Val Ser 
    1490                 1495                 1500             


Ser Thr  Arg Ser Glu Ile Thr  Lys Asn Leu Asp Val  Lys Gly Ser 
    1505                 1510                 1515             


Glu Asn  Ser Leu Pro Gly Ala  Gly Ser Ser Gly Asn  Phe Asp Arg 
    1520                 1525                 1530             


Asp Thr  Ile Ser Ser Glu Tyr  Thr His Ser Ser Ala  Ser Ser Pro 
    1535                 1540                 1545             


Glu Leu  Asn Asp Ser Ser Val  Ala Leu Ser Ser Trp  Gly Gln Gln 
    1550                 1555                 1560             


Pro Ser  Ser Gly Tyr Gln Glu  Glu Asn Gln Gly Asn  Trp Ser Glu 
    1565                 1570                 1575             


Gln Asn  His Gln Glu Ser Glu  Leu Ile Thr Thr Asp  Gly Gln Val 
    1580                 1585                 1590             


Glu Ile  Val Thr Lys Val Lys  Asp Leu Glu Lys Asn  Arg Ile Asn 
    1595                 1600                 1605             


Glu Phe  Glu Lys Ser Phe Asp  Arg Lys Thr Pro Thr  Phe Leu Glu 
    1610                 1615                 1620             


Ile Trp  Asn Asp Ser Val Asp  Gly Asp Ser Phe Ser  Ser Leu Ser 
    1625                 1630                 1635             


Ser Pro  Glu Thr Gly Lys Tyr  Ser Glu His Ser Gly  Thr His Gln 
    1640                 1645                 1650             


Glu Ser  Asn Leu Ile Ala Ser  Tyr Gln Glu Lys Asn  Glu His Asp 
    1655                 1660                 1665             


Ile Ser  Ala Thr Val Gln Pro  Glu Asp Ala Arg Val  Ile Ser Thr 
    1670                 1675                 1680             


Ser Ser  Gly Ser Asp Asp Asp  Ser Val Gly Gly Glu  Glu Ser Ile 
    1685                 1690                 1695             


Glu Glu  Glu Ile Gln Val Ala  Asn Cys His Val Ala  Glu Asp Glu 
    1700                 1705                 1710             


Ser Arg  Ala Trp Asp Ser Leu  Asn Glu Ser Asn Lys  Phe Leu Val 
    1715                 1720                 1725             


Thr Ala  Asp Pro Lys Ser Glu  Asn Ile Tyr Asp Tyr  Leu Asp Ser 
    1730                 1735                 1740             


Ser Glu  Pro Ala Glu Asn Glu  Asn Lys Ser Asn Pro  Phe Cys Asp 
    1745                 1750                 1755             


Asn Gln  Gln Ser Ser Pro Asp  Pro Trp Thr Phe Ser  Pro Leu Thr 
    1760                 1765                 1770             


Glu Thr  Glu Met Gln Ile Thr  Ala Val Glu Lys Glu  Lys Arg Ser 
    1775                 1780                 1785             


Ser Pro  Glu Thr Gly Thr Thr  Gly Asp Val Ala Trp  Gln Ile Ser 
    1790                 1795                 1800             


Pro Lys  Ala Ser Phe Pro Lys  Asn Glu Asp Asn Ser  Gln Leu Glu 
    1805                 1810                 1815             


Met Leu  Gly Phe Ser Ala Asp  Ser Thr Glu Trp Trp  Lys Ala Ser 
    1820                 1825                 1830             


Pro Gln  Glu Gly Arg Leu Ile  Glu Ser Pro Phe Glu  Arg Glu Leu 
    1835                 1840                 1845             


Ser Asp  Ser Ser Gly Val Leu  Glu Ile Asn Ser Ser  Val His Gln 
    1850                 1855                 1860             


Asn Ala  Ser Pro Trp Gly Val  Pro Val Gln Gly Asp  Ile Glu Pro 
    1865                 1870                 1875             


Val Glu  Thr His Tyr Thr Asn  Pro Phe Ser Asp Asn  His Gln Ser 
    1880                 1885                 1890             


Pro Phe  Leu Glu Gly Asn Gly  Lys Asn Ser His Glu  Gln Leu Trp 
    1895                 1900                 1905             


Asn Ile  Gln Pro Arg Gln Pro  Asp Pro Asp Ala Asp  Lys Phe Ser 
    1910                 1915                 1920             


Gln Leu  Val Lys Leu Asp Gln  Ile Lys Glu Lys Asp  Ser Arg Glu 
    1925                 1930                 1935             


Gln Thr  Phe Val Ser Ala Ala  Gly Asp Glu Leu Thr  Pro Glu Thr 
    1940                 1945                 1950             


Pro Thr  Gln Glu Gln Cys Gln  Asp Thr Met Leu Pro  Val Cys Asp 
    1955                 1960                 1965             


His Pro  Asp Ala Ala Phe Thr  His Ala Glu Glu Asn  Ser Cys Val 
    1970                 1975                 1980             


Thr Ser  Asn Val Ser Thr Asn  Glu Gly Gln Glu Thr  Asn Gln Trp 
    1985                 1990                 1995             


Glu Gln  Glu Lys Ser Tyr Leu  Gly Glu Met Thr Asn  Ser Ser Ile 
    2000                 2005                 2010             


Ala Thr  Glu Asn Phe Pro Ala  Val Ser Ser Pro Thr  Gln Leu Ile 
    2015                 2020                 2025             


Met Lys  Pro Gly Ser Glu Trp  Asp Gly Ser Thr Pro  Ser Glu Asp 
    2030                 2035                 2040             


Ser Arg  Gly Thr Phe Val Pro  Asp Ile Leu His Gly  Asn Phe Gln 
    2045                 2050                 2055             


Glu Gly  Gly Gln Leu Ala Ser  Ala Ala Pro Asp Leu  Trp Ile Asp 
    2060                 2065                 2070             


Ala Lys  Lys Pro Phe Ser Leu  Lys Ala Asp Gly Glu  Asn Pro Asp 
    2075                 2080                 2085             


Ile Leu  Thr His Cys Glu His  Asp Ser Asn Ser Gln  Ala Ser Asp 
    2090                 2095                 2100             


Ser Pro  Asp Ile Cys His Asp  Ser Glu Ala Lys Glu  Glu Thr Glu 
    2105                 2110                 2115             


Lys His  Leu Ser Ala Cys Met  Gly Pro Glu Val Glu  Ser Ser Glu 
    2120                 2125                 2130             


Leu Cys  Leu Thr Glu Pro Glu  Ile Asp Glu Glu Pro  Ile Tyr Glu 
    2135                 2140                 2145             


Pro Gly  Arg Glu Phe Val Pro  Ser Asn Ala Glu Leu  Asp Ser Glu 
    2150                 2155                 2160             


Asn Ala  Thr Val Leu Pro Pro  Ile Gly Tyr Gln Ala  Asp Ile Lys 
    2165                 2170                 2175             


Gly Ser  Ser Gln Pro Thr Ser  His Lys Gly Ser Pro  Glu Pro Ser 
    2180                 2185                 2190             


Glu Ile  Asn Gly Asp Asn Ser  Thr Gly Leu Gln Val  Ser Glu Lys 
    2195                 2200                 2205             


Gly Ala  Ser Pro Asp Met Ala  Pro Ile Leu Glu Pro  Val Asp Arg 
    2210                 2215                 2220             


Arg Ile  Pro Arg Ile Glu Asn  Val Ala Thr Ser Ile  Phe Val Thr 
    2225                 2230                 2235             


His Gln  Glu Pro Thr Pro Glu  Gly Asp Gly Ser Trp  Ile Ser Asp 
    2240                 2245                 2250             


Ser Phe  Ser Pro Glu Ser Gln  Pro Gly Ala Arg Ala  Leu Phe Asp 
    2255                 2260                 2265             


Gly Asp  Pro His Leu Ser Thr  Glu Asn Pro Ala Leu  Val Pro Asp 
    2270                 2275                 2280             


Ala Leu  Leu Ala Ser Asp Thr  Cys Leu Asp Ile Ser  Glu Ala Ala 
    2285                 2290                 2295             


Phe Asp  His Ser Phe Ser Asp  Ala Ser Gly Leu Asn  Thr Ser Thr 
    2300                 2305                 2310             


Gly Thr  Ile Asp Asp Met Ser  Lys Leu Thr Leu Ser  Glu Gly His 
    2315                 2320                 2325             


Pro Glu  Thr Pro Val Asp Gly  Asp Leu Gly Lys Gln  Asp Ile Cys 
    2330                 2335                 2340             


Ser Ser  Glu Ala Ser Trp Gly  Asp Phe Glu Tyr Asp  Val Met Gly 
    2345                 2350                 2355             


Gln Asn  Ile Asp Glu Asp Phe  Leu Arg Glu Pro Glu  His Phe Leu 
    2360                 2365                 2370             


Tyr Gly  Gly Asp Pro Pro Leu  Glu Glu Asp Ser Leu  Lys Gln Ser 
    2375                 2380                 2385             


Leu Ala  Pro Tyr Thr Pro Pro  Phe Asp Leu Ser Tyr  Leu Thr Glu 
    2390                 2395                 2400             


Pro Ala  Gln Ser Ala Glu Thr  Ile Glu Glu Ala Gly  Ser Pro Glu 
    2405                 2410                 2415             


Asp Glu  Ser Leu Gly Cys Arg  Ala Ala Glu Ile Val  Leu Ser Ala 
    2420                 2425                 2430             


Leu Pro  Asp Arg Arg Ser Glu  Gly Asn Gln Ala Glu  Thr Lys Asn 
    2435                 2440                 2445             


Arg Leu  Pro Gly Ser Gln Leu  Ala Val Leu His Ile  Arg Glu Asp 
    2450                 2455                 2460             


Pro Glu  Ser Val Tyr Leu Pro  Val Gly Ala Gly Ser  Asn Ile Leu 
    2465                 2470                 2475             


Ser Pro  Ser Asn Val Asp Trp  Glu Val Glu Thr Asp  Asn Ser Asp 
    2480                 2485                 2490             


Leu Pro  Ala Gly Gly Asp Ile  Gly Pro Pro Asn Gly  Ala Ser Lys 
    2495                 2500                 2505             


Glu Ile  Pro Glu Leu Glu Glu  Glu Lys Thr Ile Pro  Thr Lys Glu 
    2510                 2515                 2520             


Pro Glu  Gln Ile Lys Ser Glu  Tyr Lys Glu Glu Arg  Cys Thr Glu 
    2525                 2530                 2535             


Lys Asn  Glu Asp Arg His Ala  Leu His Met Asp Tyr  Ile Leu Val 
    2540                 2545                 2550             


Asn Arg  Glu Glu Asn Ser His  Ser Lys Pro Glu Thr  Cys Glu Glu 
    2555                 2560                 2565             


Arg Glu  Ser Ile Ala Glu Leu  Glu Leu Tyr Val Gly  Ser Lys Glu 
    2570                 2575                 2580             


Thr Gly  Met Gln Gly Thr Gln  Leu Ala Ser Phe Pro  Asp Thr Cys 
    2585                 2590                 2595             


Gln Pro  Ala Ser Leu Asn Glu  Arg Lys Gly Leu Ser  Ala Glu Lys 
    2600                 2605                 2610             


Met Ser  Ser Lys Gly Asp Thr  Arg Ser Ser Phe Glu  Ser Pro Ala 
    2615                 2620                 2625             


Gln Asp  Gln Ser Trp Met Phe  Leu Gly His Ser Glu  Val Gly Asp 
    2630                 2635                 2640             


Pro Ser  Leu Asp Ala Arg Asp  Ser Gly Pro Gly Trp  Ser Gly Lys 
    2645                 2650                 2655             


Thr Val  Glu Pro Phe Ser Glu  Leu Gly Leu Gly Glu  Gly Pro Gln 
    2660                 2665                 2670             


Leu Gln  Ile Leu Glu Glu Met  Lys Pro Leu Glu Ser  Leu Ala Leu 
    2675                 2680                 2685             


Glu Glu  Ala Ser Gly Pro Val  Ser Gln Ser Gln Lys  Ser Lys Ser 
    2690                 2695                 2700             


Arg Gly  Arg Ala Gly Pro Asp  Ala Val Thr His Asp  Asn Glu Trp 
    2705                 2710                 2715             


Glu Met  Leu Ser Pro Gln Pro  Val Gln Lys Asn Met  Ile Pro Asp 
    2720                 2725                 2730             


Thr Glu  Met Glu Glu Glu Thr  Glu Phe Leu Glu Leu  Gly Thr Arg 
    2735                 2740                 2745             


Ile Ser  Arg Pro Asn Gly Leu  Leu Ser Glu Asp Val  Gly Met Asp 
    2750                 2755                 2760             


Ile Pro  Phe Glu Glu Gly Val  Leu Ser Pro Ser Ala  Ala Asp Met 
    2765                 2770                 2775             


Arg Pro  Glu Pro Pro Asn Ser  Leu Asp Leu Asn Asp  Thr His Pro 
    2780                 2785                 2790             


Arg Arg  Ile Lys Leu Thr Ala  Pro Asn Ile Asn Leu  Ser Leu Asp 
    2795                 2800                 2805             


Gln Ser  Glu Gly Ser Ile Leu  Ser Asp Asp Asn Leu  Asp Ser Pro 
    2810                 2815                 2820             


Asp Glu  Ile Asp Ile Asn Val  Asp Glu Leu Asp Thr  Pro Asp Glu 
    2825                 2830                 2835             


Ala Asp  Ser Phe Glu Tyr Thr  Gly His Asp Pro Thr  Ala Asn Lys 
    2840                 2845                 2850             


Asp Ser  Gly Gln Glu Ser Glu  Ser Ile Pro Glu Tyr  Thr Ala Glu 
    2855                 2860                 2865             


Glu Glu  Arg Glu Asp Asn Arg  Leu Trp Arg Thr Val  Val Ile Gly 
    2870                 2875                 2880             


Glu Gln  Glu Gln Arg Ile Asp  Met Lys Val Ile Glu  Pro Tyr Arg 
    2885                 2890                 2895             


Arg Val  Ile Ser His Gly Gly  Asp Ser Gly Tyr Tyr  Gly Asp Gly 
    2900                 2905                 2910             


Leu Asn  Ala Ile Ile Val Phe  Ala Ala Cys Phe Leu  Pro Asp Ser 
    2915                 2920                 2925             


Ser Arg  Ala Asp Tyr His Tyr  Val Met Glu Asn Leu  Phe Leu Tyr 
    2930                 2935                 2940             


Val Ile  Ser Thr Leu Glu Leu  Met Val Ala Glu Asp  Tyr Met Ile 
    2945                 2950                 2955             


Val Tyr  Leu Asn Gly Ala Thr  Pro Arg Arg Arg Met  Pro Gly Leu 
    2960                 2965                 2970             


Gly Trp  Met Lys Lys Cys Tyr  Gln Met Ile Asp Arg  Arg Leu Arg 
    2975                 2980                 2985             


Lys Asn  Leu Lys Ser Phe Ile  Ile Val His Pro Ser  Trp Phe Ile 
    2990                 2995                 3000             


Arg Thr  Ile Leu Ala Val Thr  Arg Pro Phe Ile Ser  Ser Lys Phe 
    3005                 3010                 3015             


Ser Ser  Lys Ile Lys Tyr Val  Asn Ser Leu Ser Glu  Leu Ser Gly 
    3020                 3025                 3030             


Leu Ile  Pro Met Asp Cys Ile  His Ile Pro Glu Ser  Ile Ile Asn 
    3035                 3040                 3045             


Ile Asp  Leu Lys Leu Lys Glu  Lys Pro 
    3050                 3055         


<210>  2
<211>  3735
<212>  DNA
<213>  Homo sapiens

<400>  2
agaagaaata gcaagtgccg agaagctggc atcagaaaaa cagaggggag atttgtgtgg       60

ctgcagccga gggagaccag gaagatctgc atggtgggaa ggacctgatg atacagaggt      120

gagaaataag aaaggctgct gactttacca tctgaggcca cacatctgct gaaatggaga      180

taattaacat cactagaaac agcaagatga caatataatg tctaagtagt gacatgtttt      240

tgcacatttc cagccccttt aaatatccac acacacagga agcacaaaag gaagcacaga      300

gatccctggg agaaatgccc ggccgccatc ttgggtcatc gatgagcctc gccctgtgcc      360

tggtcccgct tgtgagggaa ggacattaga aaatgaattg atgtgttcct taaaggatgg      420

gcaggaaaac agatcctgtt gtggatattt atttgaacgg gattacagat ttgaaatgaa      480

gtcacaaagt gagcattacc aatgagagga aaacagacga gaaaatcttg atggcttcac      540

aagacatgca acaaacaaaa tggaatactg tgatgacatg aggcagccaa gctggggagg      600

agataaccac ggggcagagg gtcaggattc tggccctgct gcctaaactg tgcgttcata      660

accaaatcat ttcatatttc taaccctcaa aacaaagctg ttgtaatatc tgatctctac      720

ggttccttct gggcccaaca ttctccatat atccagccac actcattttt aatatttagt      780

tcccagatct gtactgtgac ctttctacac tgtagaataa cattactcat tttgttcaaa      840

gacccttcgt gttgctgcct aatatgtagc tgactgtttt tcctaaggag tgttctggcc      900

caggggatct gtgaacaggc tgggaagcat ctcaagatct ttccagggtt atacttacta      960

gcacacagca tgatcattac ggagtgaatt atctaatcaa catcatcctc agtgtctttg     1020

cccatactga aattcatttc ccacttttgt gcccattctc aagacctcaa aatgtcattc     1080

cattaatatc acaggattaa cttttttttt taacctggaa gaattcaatg ttacatgcag     1140

ctatgggaat ttaattacat attttgtttt ccagtgcaaa gatgactaag tcctttatcc     1200

ctcccctttg tttgattttt tttccagtat aaagttaaaa tgcttagcct tgtactgagg     1260

ctgtatacag ccacagcctc tccccatccc tccagcctta tctgtcatca ccatcaaccc     1320

ctcccatgca cctaaacaaa atctaacttg taattccttg aacatgtcag gcatacatta     1380

ttccttctgc ctgagaagct cttccttgtc tcttaaatct agaatgatgt aaagttttga     1440

ataagttgac tatcttactt catgcaaaga agggacacat atgagattca tcatcacatg     1500

agacagcaaa tactaaaagt gtaatttgat tataagagtt tagataaata tatgaaatgc     1560

aagagccaca gagggaatgt ttatggggca cgtttgtaag cctgggatgt gaagcaaagg     1620

cagggaacct catagtatct tatataatat acttcatttc tctatctcta tcacaatatc     1680

caacaagctt ttcacagaat tcatgcagtg caaatcccca aaggtaacct ttatccattt     1740

catggtgagt gcgctttaga attttggcaa atcatactgg tcacttatct caactttgag     1800

atgtgtttgt ccttgtagtt aattgaaaga aatagggcac tcttgtgagc cactttaggg     1860

ttcactcctg gcaataaaga atttacaaag agctactcag gaccagttgt taagagctct     1920

gtgtgtgtgt gtgtgtgtgt gagtgtacat gccaaagtgt gcctctctct ctttgaccca     1980

ttatttcaga cttaaaaaca agcatgtttt caaatggcac tatgagctgc caatgatgta     2040

tcaccaccat atctcattat tctccagtaa atgtgataat aatgtcatct gttaacataa     2100

aaaaagtttg acttcacaaa agcagctgga aatggacaac cacaatatgc ataaatctaa     2160

ctcctaccat cagctacaca ctgcttgaca tatattgtta gaagcacctc gcatttgtgg     2220

gttctcttaa gcaaaatact tgcattaggt ctcagctggg gctgtgcatc aggcggtttg     2280

agaaatattc aattctcagc agaagccaga atttgaattc cctcatcttt taggaatcat     2340

ttaccaggtt tggagaggat tcagacagct caggtgcttt cactaatgtc tctgaacttc     2400

tgtccctctt tgtgttcatg gatagtccaa taaataatgt tatctttgaa ctgatgctca     2460

taggagagaa tataagaact ctgagtgata tcaacattag ggattcaaag aaatattaga     2520

tttaagctca cactggtcaa aaggaaccaa gatacaaaga actctgagct gtcatcgtcc     2580

ccatctctgt gagccacaac caacagcagg acccaacgca tgtctgagat ccttaaatca     2640

aggaaaccag tgtcatgagt tgaattctcc tattatggat gctagcttct ggccatctct     2700

ggctctcctc ttgacacata ttagcttcta gcctttgctt ccacgacttt tatcttttct     2760

ccaacacatc gcttaccaat cctctctctg ctctgttgct ttggacttcc ccacaagaat     2820

ttcaacgact ctcaagtctt ttcttccatc cccaccacta acctgaatgc ctagaccctt     2880

atttttatta atttccaata gatgctgcct atgggctata ttgctttaga tgaacattag     2940

atatttaaag ctcaagaggt tcaaaatcca actcattatc ttctctttct ttcacctccc     3000

tgctcctctc cctatattac tgattgcact gaacagcatg gtccccaatg tagccatgca     3060

aatgagaaac ccagtggctc cttgtggtac atgcatgcaa gactgctgaa gccagaagga     3120

tgactgatta cgcctcatgg gtggagggga ccactcctgg gccttcgtga ttgtcaggag     3180

caagacctga gatgctccct gccttcagtg tcctctgcat ctcccctttc taatgaagat     3240

ccatagaatt tgctacattt gagaattcca attaggaact cacatgtttt atctgcccta     3300

tcaatttttt aaacttgctg aaaattaagt tttttcaaaa tctgtccttg taaattactt     3360

tttcttacag tgtcttggca tactatatca actttgattc tttgttacaa cttttcttac     3420

tcttttatca ccaaagtggc ttttattctc tttattatta ttattttctt ttactactat     3480

attacgttgt tattattttg ttctctatag tatcaattta tttgatttag tttcaattta     3540

tttttattgc tgacttttaa aataagtgat tcggggggtg ggagaacagg ggagggagag     3600

cattaggaca aatacctaat gcatgtggga cttaaaacct agatgatggg ttgataggtg     3660

cagcaaacca ctatggcaca cgtatacctg tgtaacaaac ctacacattc tgcacatgta     3720

tcccagaacg taaag                                                      3735


<210>  3
<211>  3114
<212>  DNA
<213>  Homo sapiens

<400>  3
caggcgcagt gcaggactgc tccgagcacg cctacgcgcg cattttctcc ccttcctctc       60

cctctttcca ctttcctctc cctttttctc ctctcctttc cccctcccac cacttggtct      120

ttcagtcttt cagtcagttc gtttaggtct ctccttccga cccccacccc cagctcctct      180

ccctttcctt ttccccctcc ccctttcctt tcccgtctca cgcgccaggc cgcttgcaca      240

tgcgcattag gtacaaagcc tcgctctttg tccccatctg tcgttcacac gaactcaagc      300

ctttggcatt cggcagccaa tagaatctaa gaaatggcgg aaaaatgatt ccgcctcggg      360

agctaaacct tgattggcag tttagctaac caatcgagaa cgccattttg taccccttgg      420

caggcaccga gctccgtcgt ctcgtttccg gcggtcgcgc gctcttttct cgggacggga      480

gaggccgtgt agcgtcgccg ttactccgag gagataccag tcggtagagg agaagtcgag      540

gttagaggga actgggaggc actttgctgt ctgcaatcga agttgagggt gcaaaaatgc      600

agagtaataa aacttttaac ttggagaagc aaaaccatac tccaagaaag catcatcaac      660

atcaccacca gcagcagcac caccagcagc aacagcagca gccgccacca ccgccaatac      720

ctgcaaatgg gcaacaggcc agcagccaaa atgaaggctt gactattgac ctgaagaatt      780

ttagaaaacc aggagagaag accttcaccc aacgaagccg tctttttgtg ggaaatcttc      840

ctcccgacat cactgaggaa gaaatgagga aactatttga gaaatatgga aaggcaggcg      900

aagtcttcat tcataaggat aaaggatttg gctttatccg cttggaaacc cgaaccctag      960

cggagattgc caaagtggag ctggacaata tgccactccg tggaaagcag ctgcgtgtgc     1020

gctttgcctg ccatagtgca tcccttacag ttcgaaacct tcctcagtat gtgtccaacg     1080

aactgctgga agaagccttt tctgtgtttg gccaggtaga gagggctgta gtcattgtgg     1140

atgatcgagg aaggccctca ggaaaaggca ttgttgagtt ctcagggaag ccagctgctc     1200

ggaaagctct ggacagatgc agtgaaggct ccttcctgct aaccacattt cctcgtcctg     1260

tgactgtgga gcccatggac cagttagatg atgaagaggg acttccagag aagctggtta     1320

taaaaaacca gcaatttcac aaggaacgag agcagccacc cagatttgca cagcctggct     1380

cctttgagta tgaatatgcc atgcgctgga aggcactcat tgagatggag aagcagcagc     1440

aggaccaagt ggaccgcaac atcaaggagg ctcgtgagaa gctggagatg gagatggaag     1500

ctgcacgcca tgagcaccag gtcatgctaa tgagacagga tttgatgagg cgccaagaag     1560

aacttcggag gatggaagag ctgcacaacc aagaggtgca aaaacgaaag caactggagc     1620

tcaggcagga ggaagagcgc aggcgccgtg aagaagagat gcggcggcag caagaagaaa     1680

tgatgcggcg acagcaggaa ggattcaagg gaaccttccc tgatgcgaga gagcaggaga     1740

ttcggatggg tcagatggct atgggaggtg ctatgggcat aaacaacaga ggtgccatgc     1800

cccctgctcc tgtgccagct ggtaccccag ctcctccagg acctgccact atgatgccgg     1860

atggaacttt gggattgacc ccaccaacaa ctgaacgctt tggtcaggct gctacaatgg     1920

aaggaattgg ggcaattggt ggaactcctc ctgcattcaa ccgtgcagct cctggagctg     1980

aatttgcccc aaacaaacgt cgccgatact aataagttgc agtgtctagt ttctcaaaac     2040

ccttaaaaga aggacccttt ttggactagc cagaattcta ccctggaaaa gtgttaggga     2100

ttccttccaa tagttagatc taccctgcct gtactactct agggagtatg ctggaggcag     2160

agggcaaggg aggggtggta ttaaacaagt caattctgtg tggtatattg tttaatcagt     2220

tctgtgtggt gcattcctga agtctctaat gtgactgttg agggcctggg gaaaccatgg     2280

caaagtggat ccagttagag cccattaatc ttgatcattc cggttttttt tttttttgtc     2340

catcttgttt catttgcttg ccccgccccc gagacggagt cttactctgt cgcccaggct     2400

ggagtgtagt ggcatgatct cggctcactg caatctctgc ctcccgggtt caagcttgtc     2460

caggttgatc ttgaactcct gacctcgtga tctacccacc tcggcctccc aaaatgctgg     2520

gattacaggg gtgagccacc gtgcccaacc tcacttgctt cttatcctta cactccccca     2580

gccccagaga aactgccaca tacaccacaa aaaccaaaca tcccccaatg accttagccc     2640

cattgctcca ttcactccca ggtgagaatt caggcaaacg tccacaaagg tcacaggcag     2700

cgtacatacg gttctgttat accccatata ttaccccttc atgtcctaaa gaagacattt     2760

tctcttagag attttcattt tagtgtatct ttaaaaaaaa atcttgtgtt aacttgcctc     2820

catctttttc ttgggtgagg acacccagga atgacccttt tgtgtctatg atgttgctgt     2880

tcacagcttt tcttgatagg cctagtacaa tcttgggaac agggttactg tatactgaag     2940

gtctgacagt agctcttaga ctcgcctatc ttaggtagtc atgctgtgca tttttttttt     3000

cattggtgta ctgtgtttga tttgtctcat atatttggag tttttctgaa aaatggagca     3060

gtaatgcagc atcaacctat taaaatacat tttaagcctt ttaaaaaaaa aaaa           3114


<210>  4
<211>  6614
<212>  DNA
<213>  Homo sapiens

<400>  4
gcccctcctc ttggccaaac tttccggagg ggaaggcttt ccgaggaaac gaaagcgaaa       60

ttgaaccgga gccatcttgg gcccggcgcg cagacccgcg gagtttcccg tgccgacgcc      120

ccggggccac ttccagtgcg gagtagcgga ggcgtggggg cctcgagggg ctggcgcggc      180

ccagcggtcg ggccagggtc gtgccgccgg cgggtcgggc cgggcaatgc ctcgcgggcg      240

caatgaatcc gcggcagggg tattccctca gcggatacta cacccatcca tttcaaggct      300

atgagcacag acagctcagg taccagcagc ctgggccagg atcttccccc agtagtttcc      360

tgcttaagca aatagaattt ctcaaggggc agctcccaga agcaccggtg attggaaagc      420

agacaccgtc actgccacct tccctcccag gactccggcc aaggtttcca gtactacttg      480

cctccagtac cagaggcagg caagtggaca tcaggggtgt ccccaggggc gtgcatctcg      540

gaagtcaggg gctccagaga gggttccagc atccttcacc acgtggcagg agtctgccac      600

agagaggtgt tgattgcctt tcctcacatt tccaggaact gagtatctac caagatcagg      660

aacaaaggat cttaaagttc ctggaagagc ttggggaagg gaaggccacc acagcacatg      720

atctgtctgg gaaacttggg actccgaaga aagaaatcaa tcgagtttta tactccctgg      780

caaagaaggg caagctacag aaagaggcag gaacaccccc tttgtggaaa atcgcggtct      840

ccactcaggc ttggaaccag cacagcggag tggtaagacc agacggtcat agccaaggag      900

ccccaaactc agacccgagt ttggaaccgg aagacagaaa ctccacatct gtctcagaag      960

atcttcttga gccttttatt gcagtctcag ctcaggcttg gaaccagcac agcggagtgg     1020

taagaccaga cagtcatagc caaggatccc caaactcaga cccaggtttg gaacctgaag     1080

acagcaactc cacatctgcc ttggaagatc ctcttgagtt tttagacatg gccgagatca     1140

aggagaaaat ctgcgactat ctcttcaatg tgtctgactc ctctgccctg aatttggcta     1200

aaaatattgg ccttaccaag gcccgagata taaatgctgt gctaattgac atggaaaggc     1260

agggggatgt ctatagacaa gggacaaccc ctcccatatg gcatttgaca gacaagaagc     1320

gagagaggat gcaaatcaag agaaatacga acagtgttcc tgaaaccgct ccagctgcaa     1380

tccctgagac caaaagaaac gcagagttcc tcacctgtaa tatacccaca tcaaatgcct     1440

caaataacat ggtaaccaca gaaaaagtgg agaatgggca ggaacctgtc ataaagttag     1500

aaaacaggca agaggccaga ccagaaccag caagactgaa accacctgtt cattacaatg     1560

gcccctcaaa agcagggtat gttgactttg aaaatggcca gtgggccaca gatgacatcc     1620

cagatgactt gaatagtatc cgcgcagcac caggtgagtt tcgagccatc atggagatgc     1680

cctccttcta cagtcatggc ttgccacggt gttcacccta caagaaactg acagagtgcc     1740

agctgaagaa ccccatcagc gggctgttag aatatgccca gttcgctagt caaacctgtg     1800

agttcaacat gatagagcag agtggaccac cccatgaacc tcgatttaaa ttccaggttg     1860

tcatcaatgg ccgagagttt cccccagctg aagctggaag caagaaagtg gccaagcagg     1920

atgcagctat gaaagccatg acaattctgc tagaggaagc caaagccaag gacagtggaa     1980

aatcagaaga atcatcccac tattccacag agaaagaatc agagaagact gcagagtccc     2040

agacccccac cccttcagcc acatccttct tttctgggaa gagccccgtc accacactgc     2100

ttgagtgtat gcacaaattg gggaactcct gcgaattccg tctcctgtcc aaagaaggcc     2160

ctgcccatga acccaagttc caatactgtg ttgcagtggg agcccaaact ttccccagtg     2220

tgagtgctcc cagcaagaaa gtggcaaagc agatggccgc agaggaagcc atgaaggccc     2280

tgcatgggga ggcgaccaac tccatggctt ctgataacca gcctgaaggt atgatctcag     2340

agtcacttga taacttggaa tccatgatgc ccaacaaggt caggaagatt ggcgagctcg     2400

tgagatacct gaacaccaac cctgtgggtg gccttttgga gtacgcccgc tcccatggct     2460

ttgctgctga attcaagttg gtcgaccagt ccggacctcc tcacgagccc aagttcgttt     2520

accaagcaaa agttgggggt cgctggttcc cagccgtctg cgcacacagc aagaagcaag     2580

gcaagcagga agcagcagat gcggctctcc gtgtcttgat tggggagaac gagaaggcag     2640

aacgcatggg tttcacagag ctccctctca ctggcagcac cttccatgac cagatagcca     2700

tgctgagcca ccggtgcttc aacactctga ctaacagctt ccagccctcc ttgctcggcc     2760

gcaagattct ggccgccatc attatgaaaa aagactctga ggacatgggt gtcgtcgtca     2820

gcttgggaac agggaatcgc tgtgtgaaag gagattctct cagcctaaaa ggagaaactg     2880

tcaatgactg ccatgcagaa ataatctccc ggagaggctt catcaggttt ctctacagtg     2940

agttaatgaa atacaactcc cagactgcga aggatagtat atttgaacct gctaagggag     3000

gagaaaagct ccaaataaaa aagactgtgt cattccatct gtatatcagc actgctccgt     3060

gtggagatgg cgccctcttt gacaagtcct gcagcgaccg tgctatggaa agcacagaat     3120

cccgccacta ccctgtcttc gagaatccca aacaaggaaa gctccgcacc aaggtggaga     3180

acggagaagg cacaatccct gtggaatcca gtgacattgt gcctacgtgg gatggcattc     3240

ggctcgggga gagactccgt accatgtcct gtagtgacaa aatcctacgc tggaacgtgc     3300

tgggcctgca aggggcactg ttgacccact tcctgcagcc catttatctc aaatctgtca     3360

cattgggtta ccttttcagc caagggcatc tgacccgtgc tatttgctgt cgtgtgacaa     3420

gagatgggag tgcatttgag gatggactac gacatccctt tattgtcaac caccccaagg     3480

ttggcagagt cagcatatat gattccaaaa ggcaatccgg gaagactaag gagacaagcg     3540

tcaactggtg tctggctgat ggctatgacc tggagatcct ggacggtacc agaggcactg     3600

tggatgggcc acggaatgaa ttgtcccggg tctccaaaaa gaacattttt cttctattta     3660

agaagctctg ctccttccgt taccgcaggg atctactgag actctcctat ggtgaggcca     3720

agaaagctgc ccgtgactac gagacggcca agaactactt caaaaaaggc ctgaaggata     3780

tgggctatgg gaactggatt agcaaacccc aggaggaaaa gaacttttat ctctgcccag     3840

tatagtatgc tccagtgaca gatggattag ggtgtgtcat actagggtgt gagagaggta     3900

ggtcgtagca ttcctcatca catggtcagg ggattttttt ttctcctttt tttttctttt     3960

taagccataa ttggtgatac tgaaaacttt gggttcccat ttatcctgct ttctttggga     4020

ttgctaggca aggtctggcc aggcccccct tttttccccc aagtgaagag gcagaaacct     4080

aagaagttat cttttctttc tacccaaagc atacatagtc actgagcacc tgcggtccat     4140

ttcctcttaa aagttttgtt ttgatttgtt tccatttcct ttccctttgt gtttgctaca     4200

ctgacctctt gcggtcttga ttaggtttca gtcaactctg gatcatgtca gggactgata     4260

atttcatttg tggattacgc agacccctct acttcccctc tttcccttct gagattcttt     4320

ccttgtgatc tgaatgtctc cttttccccc tcagagggca aagaggtgaa cataaaggat     4380

ttggtgaaac atttgtaagg gtaggagttg aaaactgcag ttcccagtgc cacggaagtg     4440

tgattggagc ctgcagataa tgcccagcca tcctcccatc ctgcacttta gccagctgca     4500

gggcgggcaa ggcaaggaaa gctgcttccc tggaagtgta tcactttctc cggcagctgg     4560

gaagtctaga accagccaga ctgggttaag ggagctgctc aagcaatagc agaggtttca     4620

cccggcagga tgacacagac cacttcccag ggagcacggg catgccttgg aatattgcca     4680

agcttccagc tgcctcttct cctaaagcat tcctaggaat attttccccg ccaatgctgg     4740

gcgtacaccc tagccaacgg gacaaatcct agagggtata aaatcatctc tgctcagata     4800

atcatgactt agcaagaata agggcaaaaa atcctgttgg cttaacgtca ctgttccacc     4860

cggtgtaata tctctcatga cagtgacacc aagggaagtt gactaagtca catgtaaatt     4920

aggagtgttt taaagaatgc catagatgtt gattcttaac tgctacagat aacctgtaat     4980

tgagcagatt taaaattcag gcatactttt ccatttatcc aagtgctttc atttttccag     5040

atggcttcag aagtaggctc gtgggcaggg cgcagacctg atctttatag ggttgacata     5100

gaaagcagta gttgtgggtg aaagggcagg ttgtcttcaa actctgtgag gtagaatcct     5160

ttgtctatac ctccatgaac attgactcgt gtgttcagag cctttggcct ctctgtggag     5220

tctggctctc tggctcctgt gcattctttg aatagtcact cgtaaaaact gtcagtgctt     5280

gaaactgttt cctttactca tgttgaaggg actttgttgg cttttagagt gttggtcatg     5340

actccaagag cagagcaggg aagagcccaa gcatagactt ggtgccgtgg tgatggctgc     5400

agtccagttt tgtgatgctg cttttacgtg tccctcgata acagtcagct agacacactc     5460

aggaggacta ctgaggctct gcgaccttca ggagctgagc ctgcctctct cctttagatg     5520

acagaccttc atctgggaac gtgctgagcc agcaccctca gatgatttcc ctccaaactg     5580

ctgactaggt catcctctgt ctggtagaga cattcacatc tttgctttta ttctatgctc     5640

tctgtacttt tgaccaaaaa ttgaccaaag taagaaaatg caagttctaa aaatagacta     5700

aggatgcctt tgcagaacac caaagcatcc caaggaactg gtagggaagt ggcgcctgtc     5760

tcctggagtg gaagaggcct gctccctggc tctgggtctg ctgggggcac agtaaatcag     5820

tcttggcacc cacatccagg gcagagaggt ctgtggttct cagcatcaga aggcagcgca     5880

gcccctctcc tcttcaggct acagggttgt cacctgctga gtcctcaggt tgtttggcct     5940

ctctggtcca tcttgggcat taggttctcc agcagagctc tggccagctg cctcttcttt     6000

aactgggaac acaggctctc acaagatcag aacccccact cacccccaag atcttatcta     6060

gcaagcctgt agtattcagt ttctgttgta ggaagagagc gaggcatccc tgaattccac     6120

gcatctgctg gaaacgagcc gtgtcagatc gcacatccct gcgcccccat gcccctctga     6180

gtcacacagg acagaggagg cagagcttct gcccactgtt atcttcactt tctttgtcca     6240

gtcttttgtt tttaataagc agtgaccctc cctactcttc tttttaatga tttttgtagt     6300

tgatttgtct gaactgtggc tactgtgcat tccttgaata atcacttgta aaaattgtca     6360

gtgcttgaag ctgtttcctt tactcacatt gaagggactt cgttggtttt ttggagtctt     6420

ggttgtgact ccaagagcag agtgaggaag acccccaagc atagactcgg gtactgtgat     6480

gatggctgca gtccagtttt atgattctgc ttttatgtgt cccttgataa cagtgactta     6540

acaatataca ttcctcataa ataaaaaaaa aacaagaatc tgaattctta gaaaaaaaaa     6600

aaaaaaaaaa aaaa                                                       6614


<210>  5
<211>  5424
<212>  DNA
<213>  Homo sapiens

<400>  5
accgcgcaca aggccctgcg gtgggctgaa gagttttccc tcccttggcc cagctttctc       60

aggtttgctt tttaattccc tcggtttcct gttccggagg cgcgggcggt gccactgtct      120

tggtacctgc ggtagtagcc tggctttgct ctgacggcga tctcgcggcc cgagagcctt      180

ttataggttg cttttcccgg ggatgtgaag gatacagaaa tgactgtgaa tcaacccata      240

tcatcaagga gctgataatc tagtggaaga gttagacgtg tgcatacttc actatgatat      300

gaggcagtct ctgagcttat attctctgtg gaagatgtga catatccagg cggaacatca      360

tgatgcaggg aaacacatgt cacagaatgt cgttccaccc gggacgaggg tgtccccgag      420

gacgaggagg acatggagcc agaccctcag caccatcctt taggccccaa aatctgaggc      480

tgcttcaccc tcagcagcct cctgtgcaat atcaatatga acctccaagt gccccttcca      540

ccactttctc aaactctcca gcccccaatt ttctccctcc acgaccagac tttgtaccct      600

tccccccacc catgcctccg tcagcgcaag gccctcttcc cccctgccca atcaggccgc      660

ctttccccaa ccaccagatg aggcacccct tcccagttcc tccttgtttt cctcccatgc      720

caccaccaat gccttgtcct aataaccccc cagtccctgg ggcacctcct ggacaaggca      780

ctttcccctt catgatgccc cctccctcca tgcctcatcc cccgccccct ccagtcatgc      840

cgcagcaggt taattatcag taccctccgg gctattctca ccacaacttc ccacctccca      900

gttttaatag tttccagaac aaccctagtt ctttcctgcc cagtgctaat aacagcagta      960

gtcctcattt cagacatctc cctccatacc cactcccaaa ggctcccagt gagagaaggt     1020

ccccagaaag gctgaaacac tatgatgacc acaggcaccg agatcacagt catgggcgag     1080

gtgagaggca tcggtccctg gatcggcggg agcgaggccg cagtcccgac aggagaagac     1140

aagacagccg gtacagatct gattatgacc gagggagaac accatctcgc caccgcagct     1200

acgaacggag cagagagcga gaacgggaga gacacaggca tcgagacaac cgaagatcac     1260

catctctgga aaggtcctac aaaaaagagt ataagagatc tggaaggagt tacggtttat     1320

cggttgttcc tgaacctgct ggatgcacac cagaattacc tggggagatt attaaaaata     1380

cagattcttg ggccccaccc ctggagattg tgaatcatcg ctccccaagt agggagaaga     1440

agagagctcg ttgggaggaa gaaaaagacc gttggagtga caaccagagt tctggcaaag     1500

acaagaacta tacctcaatc aaggaaaaag agcccgagga gaccatgcct gacaagaatg     1560

aggaggaaga agaagaactt cttaagcctg tgtggattcg atgcactcat tcagaaaact     1620

actactccag tgaccccatg gatcaggtgg gagattctac agtggttgga acgagtaggc     1680

ttcgtgactt atatgacaaa tttgaggagg agttggggag caggcaagaa aaggccaaag     1740

ctgctcggcc tccgtgggaa cctccaaaga cgaagctcga tgaagattta gagagttcca     1800

gtgaatccga gtgtgagtct gatgaggaca gcacctgttc tagcagctca gactctgaag     1860

tttttgacgt tattgcagaa atcaaacgca aaaaggccca ccctgaccga cttcatgatg     1920

aactttggta caacgatcca ggccagatga atgatggacc actctgcaaa tgcagcgcaa     1980

aggcaagacg cacaggaatt aggcacagca tttatcctgg agaagaggcc atcaagccct     2040

gtcgtcctat gaccaacaat gctggcagac ttttccacta ccggatcaca gtctccccgc     2100

ctacgaactt tttaactgac aggccaactg ttatagaata cgatgatcac gagtatatct     2160

ttgaaggatt ttctatgttt gcacatgccc ccctgaccaa tattccactg tgtaaagtaa     2220

ttagattcaa catagactac acgattcatt tcattgaaga gatgatgccg gagaattttt     2280

gtgtgaaagg gcttgaactc ttttcactgt tcctattcag agatattttg gaattatatg     2340

actggaatct taaaggtcct ttgtttgaag acagccctcc ctgctgccca agatttcatt     2400

tcatgccacg ttttgtaaga tttcttccag atggaggaaa ggaagtgctg tccatgcacc     2460

agattctcct gtacttgtta aggtgcagca aagccctggt gcctgaggag gagattgcca     2520

atatgcttca gtgggaggag ctggagtggc agaaatatgc agaagaatgc aaaggcatga     2580

ttgttaccaa ccctgggacg aaaccaagct ctgtccgtat cgatcaactg gatcgtgaac     2640

agttcaaccc cgatgtgatt acttttccga ttatcgtcca ctttgggata cgccctgcac     2700

agttgagtta tgcaggagac ccacagtacc aaaaactgtg gaagagttat gtgaaacttc     2760

gccacctcct agcaaatagt cccaaagtca aacaaactga caaacagaag ctggcacaga     2820

gggaggaagc cctccaaaaa atacggcaga agaatacaat gagacgagaa gtaacggtgg     2880

agctaagtag ccaaggattc tggaaaactg gcatccgttc tgatgtctgt cagcatgcaa     2940

tgatgctacc tgttctgacc catcatatcc gctaccacca atgcctaatg catttggaca     3000

agttgatagg atatactttc caagatcgtt gtctgttgca gctggccatg actcatccaa     3060

gtcatcattt aaattttgga atgaatcctg atcatgccag gaattcatta tctaactgtg     3120

gaattcggca gcccaaatac ggagacagaa aagttcatca catgcacatg cggaagaaag     3180

ggattaacac cttgataaat atcatgtcac gccttggcca agatgaccca actccctcga     3240

ggattaacca caatgaacgg ttggaattcc tgggtgatgc tgttgttgaa tttctgacca     3300

gcgtccattt gtactatttg tttcctagtc tggaagaagg aggattagca acctatcgga     3360

ctgccattgt tcagaatcag caccttgcca tgctagcaaa gaaacttgaa ctggatcgat     3420

ttatgctgta tgctcacggg cctgaccttt gtagagaatc ggaccttcga catgcaatgg     3480

ccaattgttt tgaagcgtta ataggagctg tttacttgga gggaagcctg gaggaagcca     3540

agcagttatt tggacgcttg ctctttaatg atccggacct gcgcgaagtc tggctcaatt     3600

atcctctcca cccactccaa ctacaagagc caaatactga tcgacaactt attgaaactt     3660

ctccagttct acaaaaactt actgagtttg aagaagcaat tggagtaatt tttactcatg     3720

ttcgacttct ggcaagggca ttcacattga gaactgtggg atttaaccat ctgaccctag     3780

gccacaatca gagaatggaa ttcctaggtg actccataat gcaactggta gccacagagt     3840

acttattcat tcatttccca gatcatcatg aaggacactt aactttgttg cgaagctctt     3900

tggtgaataa tagaactcag gccaaggtag cggaggagct gggcatgcag gagtacgcca     3960

taaccaacga caagaccaag aggcctgtgg cgcttcgcac caagaccttg gcggaccttt     4020

tggaatcatt tattgcagcg ctgtacattg ataaggattt ggaatatgtt catactttca     4080

tgaatgtctg cttctttcca cgattgaaag agttcatttt gaatcaggat tggaatgacc     4140

ccaaatccca gcttcagcag tgttgcttga cacttaggac agaaggaaaa gagccagaca     4200

ttcctctgta caagactctg cagacagtgg gcccatccca tgcccgaacc tacactgtgg     4260

ctgtttattt caagggagaa agaataggct gtgggaaagg accaagtatt cagcaagcgg     4320

aaatgggagc agcaatggat gcgcttgaaa aatataattt tccccagatg gcccatcaga     4380

agcggttcat cgaacggaag tacagacaag agttaaaaga aatgaggtgg gaaagagagc     4440

atcaagagag agagccagat gagactgaag acatcaagaa ataaaggagg gcatgcaagt     4500

gtggagtatt tacttgctca gtaactgtga ctgttgtcta ttgagaccta gcctagtttt     4560

cctgcagaca atgaatgaag tgtgctcatt gaaataaaat acagagtcaa atcgctattg     4620

ttgttttaat gatctgtttt tagctggatg gtctttatta caaagtatta gatttttctt     4680

ctatttaacg gaaaacttga ctttggtgaa tgtgcattac ttccttttat tttgctcttt     4740

aaataataaa attcaagaag catattctat gtggaataga tcctgttttt ccatctgtgt     4800

cccagattgt gaccctagac tttcaattga caagtaaaaa attgacttta ctagacattt     4860

tgactgtgct ctagtaacat ctatcctttt tcaaatctct ggatttttaa gtagattgtt     4920

cagctttcat ccggtggctg ttcatcaagt tatcagctgc aaatattgaa cttacctctc     4980

tctaagcagt gagtgttttg tagaaggaat ccgtttaaca attaattggc taatgggaga     5040

aggggaaaga ctgatattca agtcatacag attctttgaa tcattagaat aggagagaaa     5100

tcatgattct aagccaggcc acactttaaa ccaagtgctc tcaccctggg gttagtggaa     5160

cctttaagaa gttaatgaac agacttcaag gaagtcaaaa acctcccaat actatattca     5220

attttctgtg tgtgtttgag atttgagagg gcatggggag caggaaggag gagggtttat     5280

agcttttatc agcctctcta agtgggccct gcagtaaaag gctaacatga cattcaaaga     5340

cataacattt taaaaaaagt tattccaaac taaacatcac tggtttctta ttaataaagg     5400

caaaacttct ttgtaaaaca aaaa                                            5424


<210>  6
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  6
tgttattcta cagtgtagaa aggtc                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  7
gacccttcgt gttgctgcct aatat                                             25


<210>  8
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  8
gcatttgtgg gttctctta                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  9
gctcaggtgc tttcactaa                                                    19


<210>  10
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  10
gctcatagga gagaatata                                                    19


<210>  11
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  11
ccagtgtcat gagttgaatt ctcct                                             25


<210>  12
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  12
gctctcctct tgacacata                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  13
ccaacacatc gcttaccaa                                                    19


<210>  14
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  14
gcctatgggc tatattgctt tagat                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  15
cctttctaat gaagatccat agaat                                             25


<210>  16
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  16
ccatagaatt tgctacatt                                                    19


<210>  17
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  17
gatacagagg tgagaaataa gaaag                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  18
cagcaagatg acaatataat gtcta                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  19
gagaaaatct tgatggcttc acaag                                             25


<210>  20
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  20
cagagaagct ggttataaa                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  21
ctgaggaaga aatgaggaa                                                    19


<210>  22
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  22
gctcctttga gtatgaatat                                                   20


<210>  23
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  23
ggaccagtta gatgatgaa                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  24
cccgagtttg gaaccggaa                                                    19


<210>  25
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  25
tcaaatgcct caaataacat ggtaa                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  26
agaatatgcc cagttcgcta gtcaa                                             25


<210>  27
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  27
gcaggatgca gctatgaaa                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  28
ccacactgct tgagtgtat                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  29
gcgaccaact ccatggctt                                                    19


<210>  30
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  30
ggtatgatct cagagtcact tgata                                             25


<210>  31
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  31
gcccaagttc gtttaccaa                                                    19


<210>  32
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  32
gcttcaacac tctgactaa                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  33
gcacagaatc ccgccacta                                                    19


<210>  34
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  34
gacaagagat gggagtgcat ttgag                                             25


<210>  35
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  35
cagagtcagc atatatgatt ccaaa                                             25


<210>  36
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  36
gacagcaact ccacatctgc ctt                                               23


<210>  37
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  37
tatgggctat gggaactgga tt                                                22


<210>  38
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  38
gcagcctcct gtgcaatat                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  39
gggagattct acagtggtt                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  40
ggttggaacg agtaggctt                                                    19


<210>  41
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  41
cagtgaatcc gagtgtgagt ctgat                                             25


<210>  42
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  42
ccaatattcc actgtgtaa                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  43
gcccaagatt tcatttcat                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  44
cctagcaaat agtcccaaa                                                    19


<210>  45
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  45
cggtggagct aagtagccaa ggatt                                             25


<210>  46
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  46
gcatttggac aagttgata                                                    19


<210>  47
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  47
cagcgtccat ttgtactatt tgttt                                             25


<210>  48
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  48
cagttatttg gacgcttgct cttta                                             25


<210>  49
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  49
gccaaatact gatcgacaa                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  50
gaatgaggag gaagaagaa                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  51
ggaattaggc acagcattt                                                    19


<210>  52
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  52
tattccactg tgtaaagtaa tt                                                22


<210>  53
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  53
aatgcaaagg catgattgtt                                                   20


<210>  54
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  54
gcagaagaat acaatgaga                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  55
gggattaaca ccttgataa                                                    19


<210>  56
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  56
tctggaagaa ggaggattag                                                   20


<210>  57
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  57
ccacaatcag agaatggaat t                                                 21


<210>  58
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  58
aggaaaagag ccagacatt                                                    19


<210>  59
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  59
agactgaaga catcaagaaa taa                                               23


