                         SEQUENCE LISTING

<110>  THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW 
       YORK
 
<120>  DETECTION OF PROTEIN ARGININE DEMETHYLASE ACTIVITY

<130>  011520.01165

<150>  62/032209
<151>  2014-08-01

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Peptide

<400>  1

Cys Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
1               5                   10                  15      


<210>  2
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  2
ggagctcatg gcgcagagct ggtt                                              24


<210>  3
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  3
gcaagctttc agaagctgaa cgca                                              24


<210>  4
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  4
gagaattcat gctggaactg gacggacgca cg                                     32


<210>  5
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  5
ggaagctttc accccctcac gcagtgagca ac                                     32


<210>  6
<211>  941
<212>  PRT
<213>  artificial sequence

<220>
<223>  Jumonji Fusion Protein

<400>  6

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Met Ala Gln Ser Trp Phe Lys Arg His 
385                 390                 395                 400 


Pro Leu Gly Ile Tyr Pro Arg Gly Asn Ala Lys Asn Leu Asp Glu Leu 
                405                 410                 415     


Val Ser Pro Arg Phe Gly Ile Leu Ser Thr Leu Gln Phe Ala Ser Lys 
            420                 425                 430         


Gly Arg Ala Gly Lys Cys Cys Ile Leu Gly Ser Gln Pro Ala Glu Glu 
        435                 440                 445             


Ala Phe Val Asp Val Met Leu His Leu Leu Ser Phe Val Ala Val Asp 
    450                 455                 460                 


Asp Met Cys Arg Leu Ser Ala Val Cys Thr Gly Trp Tyr Cys Phe Ile 
465                 470                 475                 480 


His Ala Ser Asp Ala Phe Lys Gln Ala His Gly Leu Leu Ser Pro Thr 
                485                 490                 495     


Tyr Thr Cys Phe Glu Gly Ser Trp Lys Glu Thr Ala Ile Arg Arg Phe 
            500                 505                 510         


Ile Lys Leu Arg Ser Lys Gln Arg Leu Asn Thr Ala Lys Arg Met Arg 
        515                 520                 525             


Leu Glu Gly Gly Thr Pro Gly Val Gly Glu Thr Val Asn Leu Ser His 
    530                 535                 540                 


Arg Pro Val Met Val Lys Arg Ala Phe Tyr Asn Asp Gln Leu Phe Gln 
545                 550                 555                 560 


Ala Trp Met Cys Thr Ile Leu Pro Cys His Tyr His Leu Arg Gln Ser 
                565                 570                 575     


Ser Ile Ala Gly Thr Ala Thr Ala Asn Arg Gln Pro Ser Val Leu Ser 
            580                 585                 590         


Ala Arg Gly Arg Tyr Arg Ser Pro Leu Lys Glu Val Pro Arg Cys Ser 
        595                 600                 605             


Gly Leu Ser Val Asp Glu Phe Arg Thr Arg Phe Glu Glu Thr Asn Leu 
    610                 615                 620                 


Pro Val Ile Ile Ala Asp Val Ala Thr Glu Trp Pro Ile Tyr Lys Ile 
625                 630                 635                 640 


Leu Gln Glu Lys Phe Glu Asn Leu Ala Val Met Gln Lys Lys Leu Phe 
                645                 650                 655     


Arg Pro Gly Thr Arg Pro Asp Val Pro Met Cys Cys Glu His Thr Thr 
            660                 665                 670         


Met Ser Val Ala Asp Tyr Val Arg Tyr Ala Arg Asp Gln Thr Asp Glu 
        675                 680                 685             


Arg Pro Ile Tyr Leu Phe Asp Ser Glu Phe Gly Thr Phe Met Asp Val 
    690                 695                 700                 


Glu Ser Leu Tyr Thr Val Pro Glu Tyr Phe Ser Arg Asp Asp Phe Phe 
705                 710                 715                 720 


Lys Val Leu Gly Gly Ala Arg Pro Lys Tyr Arg Trp Ile Ile Ala Gly 
                725                 730                 735     


Pro Arg Arg Gly Gly Ser Ser Phe His Val Asp Pro Asn Tyr Thr Ser 
            740                 745                 750         


Ala Trp Asn Ala Asn Leu Thr Gly Leu Lys Arg Trp Ile Leu Leu Pro 
        755                 760                 765             


Pro Gly His Thr Pro Ala Gly Val Phe Pro Ser Glu Asp Met Ser Glu 
    770                 775                 780                 


Val Val Thr Pro Val Ser Leu Thr Glu Trp Leu Leu Asn His Tyr Asp 
785                 790                 795                 800 


Ala Thr Val Glu Lys Trp Arg Asp Val Ala Tyr Glu Cys Val Cys Gly 
                805                 810                 815     


Pro Gly Asp Ile Met Phe Ile Pro Cys Gly Trp Trp His Phe Val Ile 
            820                 825                 830         


Asn Leu Glu Asp Ser Val Ala Ile Thr Gln Asn Tyr Val Ser Lys Cys 
        835                 840                 845             


Asn Leu Ser Ser Val Leu Lys Phe Leu Ser Val Met Lys Ser Ser Ile 
    850                 855                 860                 


Ser Gly Ile Asp Glu Asp Val Asp Asn Cys Asp Thr Ser Arg Met Val 
865                 870                 875                 880 


Glu Thr Arg Arg Ala Asn Phe Ala Glu Glu Phe Ala Ala Ala Met His 
                885                 890                 895     


Leu Ser Tyr Pro Glu Leu Met Gln Thr Val Ala Gly Glu Ala Lys Arg 
            900                 905                 910         


Glu Ala Glu Glu Arg His Glu Lys Lys Lys Met Arg Ala Ala Leu Pro 
        915                 920                 925             


Leu Leu Asp Val Gly Ser Asn Gly Phe Ala Phe Ser Phe 
    930                 935                 940     


<210>  7
<211>  841
<212>  PRT
<213>  artificial sequence

<220>
<223>  Jumonji Fusion Protein

<400>  7

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Met Leu Glu Leu Asp Gly Arg Thr Leu 
385                 390                 395                 400 


Thr Phe Glu Gln Phe Arg Glu Cys Cys Leu Lys Pro Asn Leu Pro Ala 
                405                 410                 415     


Ile Ile Arg His Ala Ala Val Asp Ser Thr Thr Asn Ser Val Gly Gly 
            420                 425                 430         


Ser Gly Pro Ser Pro Tyr Phe Ser Pro Leu Gly Asp Met Gln Ser His 
        435                 440                 445             


Leu Ser Pro Ile Gly Val Val Asn Leu Phe Gly Gly Asp His Val Val 
    450                 455                 460                 


Pro Ala Thr Glu Ser Pro Ala Thr Val Ala Ser Asp Ser Leu Lys Asp 
465                 470                 475                 480 


Gly Ile Ser Glu Gly His Met Lys Cys Ser Lys Leu Arg Leu Phe Glu 
                485                 490                 495     


Val Ile Glu Arg Trp Arg Gly Ser Pro Thr Leu Val Tyr Val Lys Asp 
            500                 505                 510         


Trp His Met Gln Ser Asp Leu Glu Ala Val Ser Ser Cys Val Gly Ala 
        515                 520                 525             


Pro Asp Leu Arg Gly Val Ser Ser Val Val Ala Ser Asp Ala Glu Glu 
    530                 535                 540                 


Gly Asn Ala Ala Val Cys Asn Gly Arg Arg Ala Val Val His Gly Gly 
545                 550                 555                 560 


Asn Leu Tyr Cys Val Pro Cys Tyr Leu Gly Pro Asp Trp Met Asp Glu 
                565                 570                 575     


Phe Cys Arg Phe Ser Gln His Gly Asp Ser Lys Tyr Arg Tyr Phe Gly 
            580                 585                 590         


Glu Glu Glu Ser Asp Tyr Arg Phe Ala Tyr Ile Gly Pro Pro Arg Ser 
        595                 600                 605             


Trp Thr Pro Leu His Phe Asp Val Phe Gly Thr Tyr Ser Trp Ser Leu 
    610                 615                 620                 


Asn Val Cys Gly Glu Lys Leu Trp Phe Phe Pro Thr Pro Glu Gly Asn 
625                 630                 635                 640 


Gln Thr Leu Leu Arg Gly Gly Leu His Gly Val Ala Leu Ala Pro Asp 
                645                 650                 655     


Ile Arg Thr Thr Ala Gly Ala Glu Leu Trp Thr Val Thr Gln Tyr Pro 
            660                 665                 670         


Gly Asp Leu Val Phe Val Pro Ser Cys Tyr Leu His Gln Val His Asn 
        675                 680                 685             


Val Lys Gly Ser Cys Phe Thr Leu Pro Gln Thr Arg Glu Thr Ala Asn 
    690                 695                 700                 


Val Ala Ala Thr Ser Cys Glu Gly Ile Glu Ser Val Ser Thr Pro Asn 
705                 710                 715                 720 


Glu Ser Val Val Asp Leu Val Ile Ser Ile Asn His Asn Trp Cys Asn 
                725                 730                 735     


Glu Trp Cys Val Glu Arg Met Val Asp Ala Phe Cys Arg Asp Ala Asn 
            740                 745                 750         


Arg Leu Trp Met Leu Leu Gly Asp Glu Val Arg Leu Thr Leu Phe Gly 
        755                 760                 765             


Asp Asp Val Gly Ala Trp His Asp His Val Glu Asn Leu Leu Met Gly 
    770                 775                 780                 


Gly Thr Asn Trp Asn Phe Gly Cys Ile Arg Ser Phe Leu Val Tyr Arg 
785                 790                 795                 800 


Leu Gln Val Leu Arg Ser Ser Gly Pro Thr Thr Ala Glu Gly Asp Asn 
                805                 810                 815     


Val Arg Arg Leu Ile Glu Leu Cys Leu Gly Lys Val Asn Glu Thr Glu 
            820                 825                 830         


Met Arg Val Ala His Cys Val Arg Gly 
        835                 840     


<210>  8
<211>  550
<212>  PRT
<213>  Trypanosoma brucei

<400>  8

Met Ala Gln Ser Trp Phe Lys Arg His Pro Leu Gly Ile Tyr Pro Arg 
1               5                   10                  15      


Gly Asn Ala Lys Asn Leu Asp Glu Leu Val Ser Pro Arg Phe Gly Ile 
            20                  25                  30          


Leu Ser Thr Leu Gln Phe Ala Ser Lys Gly Arg Ala Gly Lys Cys Cys 
        35                  40                  45              


Ile Leu Gly Ser Gln Pro Ala Glu Glu Ala Phe Val Asp Val Met Leu 
    50                  55                  60                  


His Leu Leu Ser Phe Val Ala Val Asp Asp Met Cys Arg Leu Ser Ala 
65                  70                  75                  80  


Val Cys Thr Gly Trp Tyr Cys Phe Ile His Ala Ser Asp Ala Phe Lys 
                85                  90                  95      


Gln Ala His Gly Leu Leu Ser Pro Thr Tyr Thr Cys Phe Glu Gly Ser 
            100                 105                 110         


Trp Lys Glu Thr Ala Ile Arg Arg Phe Ile Lys Leu Arg Ser Lys Gln 
        115                 120                 125             


Arg Leu Asn Thr Ala Lys Arg Met Arg Leu Glu Gly Gly Thr Pro Gly 
    130                 135                 140                 


Val Gly Glu Thr Val Asn Leu Ser His Arg Pro Val Met Val Lys Arg 
145                 150                 155                 160 


Ala Phe Tyr Asn Asp Gln Leu Phe Gln Ala Trp Met Cys Thr Ile Leu 
                165                 170                 175     


Pro Cys His Tyr His Leu Arg Gln Ser Ser Ile Ala Gly Thr Ala Thr 
            180                 185                 190         


Ala Asn Arg Gln Pro Ser Val Leu Ser Ala Arg Gly Arg Tyr Arg Ser 
        195                 200                 205             


Pro Leu Lys Glu Val Pro Arg Cys Ser Gly Leu Ser Val Asp Glu Phe 
    210                 215                 220                 


Arg Thr Arg Phe Glu Glu Thr Asn Leu Pro Val Ile Ile Ala Asp Val 
225                 230                 235                 240 


Ala Thr Glu Trp Pro Ile Tyr Lys Ile Leu Gln Glu Lys Phe Glu Asn 
                245                 250                 255     


Leu Ala Val Met Gln Lys Lys Leu Phe Arg Pro Gly Thr Arg Pro Asp 
            260                 265                 270         


Val Pro Met Cys Cys Glu His Thr Thr Met Ser Val Ala Asp Tyr Val 
        275                 280                 285             


Arg Tyr Ala Arg Asp Gln Thr Asp Glu Arg Pro Ile Tyr Leu Phe Asp 
    290                 295                 300                 


Ser Glu Phe Gly Thr Phe Met Asp Val Glu Ser Leu Tyr Thr Val Pro 
305                 310                 315                 320 


Glu Tyr Phe Ser Arg Asp Asp Phe Phe Lys Val Leu Gly Gly Ala Arg 
                325                 330                 335     


Pro Lys Tyr Arg Trp Ile Ile Ala Gly Pro Arg Arg Gly Gly Ser Ser 
            340                 345                 350         


Phe His Val Asp Pro Asn Tyr Thr Ser Ala Trp Asn Ala Asn Leu Thr 
        355                 360                 365             


Gly Leu Lys Arg Trp Ile Leu Leu Pro Pro Gly His Thr Pro Ala Gly 
    370                 375                 380                 


Val Phe Pro Ser Glu Asp Met Ser Glu Val Val Thr Pro Val Ser Leu 
385                 390                 395                 400 


Thr Glu Trp Leu Leu Asn His Tyr Asp Ala Thr Val Glu Lys Trp Arg 
                405                 410                 415     


Asp Val Ala Tyr Glu Cys Val Cys Gly Pro Gly Asp Ile Met Phe Ile 
            420                 425                 430         


Pro Cys Gly Trp Trp His Phe Val Ile Asn Leu Glu Asp Ser Val Ala 
        435                 440                 445             


Ile Thr Gln Asn Tyr Val Ser Lys Cys Asn Leu Ser Ser Val Leu Lys 
    450                 455                 460                 


Phe Leu Ser Val Met Lys Ser Ser Ile Ser Gly Ile Asp Glu Asp Val 
465                 470                 475                 480 


Asp Asn Cys Asp Thr Ser Arg Met Val Glu Thr Arg Arg Ala Asn Phe 
                485                 490                 495     


Ala Glu Glu Phe Ala Ala Ala Met His Leu Ser Tyr Pro Glu Leu Met 
            500                 505                 510         


Gln Thr Val Ala Gly Glu Ala Lys Arg Glu Ala Glu Glu Arg His Glu 
        515                 520                 525             


Lys Lys Lys Met Arg Ala Ala Leu Pro Leu Leu Asp Val Gly Ser Asn 
    530                 535                 540                 


Gly Phe Ala Phe Ser Phe 
545                 550 


<210>  9
<211>  450
<212>  PRT
<213>  Trypanosoma brucei

<400>  9

Met Leu Glu Leu Asp Gly Arg Thr Leu Thr Phe Glu Gln Phe Arg Glu 
1               5                   10                  15      


Cys Cys Leu Lys Pro Asn Leu Pro Ala Ile Ile Arg His Ala Ala Val 
            20                  25                  30          


Asp Ser Thr Thr Asn Ser Val Gly Gly Ser Gly Pro Ser Pro Tyr Phe 
        35                  40                  45              


Ser Pro Leu Gly Asp Met Gln Ser His Leu Ser Pro Ile Gly Val Val 
    50                  55                  60                  


Asn Leu Phe Gly Gly Asp His Val Val Pro Ala Thr Glu Ser Pro Ala 
65                  70                  75                  80  


Thr Val Ala Ser Asp Ser Leu Lys Asp Gly Ile Ser Glu Gly His Met 
                85                  90                  95      


Lys Cys Ser Lys Leu Arg Leu Phe Glu Val Ile Glu Arg Trp Arg Gly 
            100                 105                 110         


Ser Pro Thr Leu Val Tyr Val Lys Asp Trp His Met Gln Ser Asp Leu 
        115                 120                 125             


Glu Ala Val Ser Ser Cys Val Gly Ala Pro Asp Leu Arg Gly Val Ser 
    130                 135                 140                 


Ser Val Val Ala Ser Asp Ala Glu Glu Gly Asn Ala Ala Val Cys Asn 
145                 150                 155                 160 


Gly Arg Arg Ala Val Val His Gly Gly Asn Leu Tyr Cys Val Pro Cys 
                165                 170                 175     


Tyr Leu Gly Pro Asp Trp Met Asp Glu Phe Cys Arg Phe Ser Gln His 
            180                 185                 190         


Gly Asp Ser Lys Tyr Arg Tyr Phe Gly Glu Glu Glu Ser Asp Tyr Arg 
        195                 200                 205             


Phe Ala Tyr Ile Gly Pro Pro Arg Ser Trp Thr Pro Leu His Phe Asp 
    210                 215                 220                 


Val Phe Gly Thr Tyr Ser Trp Ser Leu Asn Val Cys Gly Glu Lys Leu 
225                 230                 235                 240 


Trp Phe Phe Pro Thr Pro Glu Gly Asn Gln Thr Leu Leu Arg Gly Gly 
                245                 250                 255     


Leu His Gly Val Ala Leu Ala Pro Asp Ile Arg Thr Thr Ala Gly Ala 
            260                 265                 270         


Glu Leu Trp Thr Val Thr Gln Tyr Pro Gly Asp Leu Val Phe Val Pro 
        275                 280                 285             


Ser Cys Tyr Leu His Gln Val His Asn Val Lys Gly Ser Cys Phe Thr 
    290                 295                 300                 


Leu Pro Gln Thr Arg Glu Thr Ala Asn Val Ala Ala Thr Ser Cys Glu 
305                 310                 315                 320 


Gly Ile Glu Ser Val Ser Thr Pro Asn Glu Ser Val Val Asp Leu Val 
                325                 330                 335     


Ile Ser Ile Asn His Asn Trp Cys Asn Glu Trp Cys Val Glu Arg Met 
            340                 345                 350         


Val Asp Ala Phe Cys Arg Asp Ala Asn Arg Leu Trp Met Leu Leu Gly 
        355                 360                 365             


Asp Glu Val Arg Leu Thr Leu Phe Gly Asp Asp Val Gly Ala Trp His 
    370                 375                 380                 


Asp His Val Glu Asn Leu Leu Met Gly Gly Thr Asn Trp Asn Phe Gly 
385                 390                 395                 400 


Cys Ile Arg Ser Phe Leu Val Tyr Arg Leu Gln Val Leu Arg Ser Ser 
                405                 410                 415     


Gly Pro Thr Thr Ala Glu Gly Asp Asn Val Arg Arg Leu Ile Glu Leu 
            420                 425                 430         


Cys Leu Gly Lys Val Asn Glu Thr Glu Met Arg Val Ala His Cys Val 
        435                 440                 445             


Arg Gly 
    450 


<210>  10
<211>  941
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion Protein

<400>  10

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Met Ala Gln Ser Trp Phe Lys Arg His 
385                 390                 395                 400 


Pro Leu Gly Ile Tyr Pro Arg Gly Asn Ala Lys Asn Leu Asp Glu Leu 
                405                 410                 415     


Val Ser Pro Arg Phe Gly Ile Leu Ser Thr Leu Gln Phe Ala Ser Lys 
            420                 425                 430         


Gly Arg Ala Gly Lys Cys Cys Ile Leu Gly Ser Gln Pro Ala Glu Glu 
        435                 440                 445             


Ala Phe Val Asp Val Met Leu His Leu Leu Ser Phe Val Ala Val Asp 
    450                 455                 460                 


Asp Met Cys Arg Leu Ser Ala Val Cys Thr Gly Trp Tyr Cys Phe Ile 
465                 470                 475                 480 


His Ala Ser Asp Ala Phe Lys Gln Ala His Gly Leu Leu Ser Pro Thr 
                485                 490                 495     


Tyr Thr Cys Phe Glu Gly Ser Trp Lys Glu Thr Ala Ile Arg Arg Phe 
            500                 505                 510         


Ile Lys Leu Arg Ser Lys Gln Arg Leu Asn Thr Ala Lys Arg Met Arg 
        515                 520                 525             


Leu Glu Gly Gly Thr Pro Gly Val Gly Glu Thr Val Asn Leu Ser His 
    530                 535                 540                 


Arg Pro Val Met Val Lys Arg Ala Phe Tyr Asn Asp Gln Leu Phe Gln 
545                 550                 555                 560 


Ala Trp Met Cys Thr Ile Leu Pro Cys His Tyr His Leu Arg Gln Ser 
                565                 570                 575     


Ser Ile Ala Gly Thr Ala Thr Ala Asn Arg Gln Pro Ser Val Leu Ser 
            580                 585                 590         


Ala Arg Gly Arg Tyr Arg Ser Pro Leu Lys Glu Val Pro Arg Cys Ser 
        595                 600                 605             


Gly Leu Ser Val Asp Glu Phe Arg Thr Arg Phe Glu Glu Thr Asn Leu 
    610                 615                 620                 


Pro Val Ile Ile Ala Asp Val Ala Thr Glu Trp Pro Ile Tyr Lys Ile 
625                 630                 635                 640 


Leu Gln Glu Lys Phe Glu Asn Leu Ala Val Met Gln Lys Lys Leu Phe 
                645                 650                 655     


Arg Pro Gly Thr Arg Pro Asp Val Pro Met Cys Cys Glu His Thr Thr 
            660                 665                 670         


Met Ser Val Ala Asp Tyr Val Arg Tyr Ala Arg Asp Gln Thr Asp Glu 
        675                 680                 685             


Arg Pro Ile Tyr Leu Phe Asp Ser Glu Phe Gly Thr Phe Met Asp Val 
    690                 695                 700                 


Glu Ser Leu Tyr Thr Val Pro Glu Tyr Phe Ser Arg Asp Asp Phe Phe 
705                 710                 715                 720 


Lys Val Leu Gly Gly Ala Arg Pro Lys Tyr Arg Trp Ile Ile Ala Gly 
                725                 730                 735     


Pro Arg Arg Gly Gly Ser Ser Phe Ala Val Asp Pro Asn Tyr Thr Ser 
            740                 745                 750         


Ala Trp Asn Ala Asn Leu Thr Gly Leu Lys Arg Trp Ile Leu Leu Pro 
        755                 760                 765             


Pro Gly His Thr Pro Ala Gly Val Phe Pro Ser Glu Asp Met Ser Glu 
    770                 775                 780                 


Val Val Thr Pro Val Ser Leu Thr Glu Trp Leu Leu Asn His Tyr Asp 
785                 790                 795                 800 


Ala Thr Val Glu Lys Trp Arg Asp Val Ala Tyr Glu Cys Val Cys Gly 
                805                 810                 815     


Pro Gly Asp Ile Met Phe Ile Pro Cys Gly Trp Trp His Phe Val Ile 
            820                 825                 830         


Asn Leu Glu Asp Ser Val Ala Ile Thr Gln Asn Tyr Val Ser Lys Cys 
        835                 840                 845             


Asn Leu Ser Ser Val Leu Lys Phe Leu Ser Val Met Lys Ser Ser Ile 
    850                 855                 860                 


Ser Gly Ile Asp Glu Asp Val Asp Asn Cys Asp Thr Ser Arg Met Val 
865                 870                 875                 880 


Glu Thr Arg Arg Ala Asn Phe Ala Glu Glu Phe Ala Ala Ala Met His 
                885                 890                 895     


Leu Ser Tyr Pro Glu Leu Met Gln Thr Val Ala Gly Glu Ala Lys Arg 
            900                 905                 910         


Glu Ala Glu Glu Arg His Glu Lys Lys Lys Met Arg Ala Ala Leu Pro 
        915                 920                 925             


Leu Leu Asp Val Gly Ser Asn Gly Phe Ala Phe Ser Phe 
    930                 935                 940     


<210>  11
<211>  841
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion Protein

<400>  11

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Met Leu Glu Leu Asp Gly Arg Thr Leu 
385                 390                 395                 400 


Thr Phe Glu Gln Phe Arg Glu Cys Cys Leu Lys Pro Asn Leu Pro Ala 
                405                 410                 415     


Ile Ile Arg His Ala Ala Val Asp Ser Thr Thr Asn Ser Val Gly Gly 
            420                 425                 430         


Ser Gly Pro Ser Pro Tyr Phe Ser Pro Leu Gly Asp Met Gln Ser His 
        435                 440                 445             


Leu Ser Pro Ile Gly Val Val Asn Leu Phe Gly Gly Asp His Val Val 
    450                 455                 460                 


Pro Ala Thr Glu Ser Pro Ala Thr Val Ala Ser Asp Ser Leu Lys Asp 
465                 470                 475                 480 


Gly Ile Ser Glu Gly His Met Lys Cys Ser Lys Leu Arg Leu Phe Glu 
                485                 490                 495     


Val Ile Glu Arg Trp Arg Gly Ser Pro Thr Leu Val Tyr Val Lys Asp 
            500                 505                 510         


Trp His Met Gln Ser Asp Leu Glu Ala Val Ser Ser Cys Val Gly Ala 
        515                 520                 525             


Pro Asp Leu Arg Gly Val Ser Ser Val Val Ala Ser Asp Ala Glu Glu 
    530                 535                 540                 


Gly Asn Ala Ala Val Cys Asn Gly Arg Arg Ala Val Val His Gly Gly 
545                 550                 555                 560 


Asn Leu Tyr Cys Val Pro Cys Tyr Leu Gly Pro Asp Trp Met Asp Glu 
                565                 570                 575     


Phe Cys Arg Phe Ser Gln His Gly Asp Ser Lys Tyr Arg Tyr Phe Gly 
            580                 585                 590         


Glu Glu Glu Ser Asp Tyr Arg Phe Ala Tyr Ile Gly Pro Pro Arg Ser 
        595                 600                 605             


Trp Thr Pro Leu Ala Phe Asp Val Phe Gly Thr Tyr Ser Trp Ser Leu 
    610                 615                 620                 


Asn Val Cys Gly Glu Lys Leu Trp Phe Phe Pro Thr Pro Glu Gly Asn 
625                 630                 635                 640 


Gln Thr Leu Leu Arg Gly Gly Leu His Gly Val Ala Leu Ala Pro Asp 
                645                 650                 655     


Ile Arg Thr Thr Ala Gly Ala Glu Leu Trp Thr Val Thr Gln Tyr Pro 
            660                 665                 670         


Gly Asp Leu Val Phe Val Pro Ser Cys Tyr Leu His Gln Val His Asn 
        675                 680                 685             


Val Lys Gly Ser Cys Phe Thr Leu Pro Gln Thr Arg Glu Thr Ala Asn 
    690                 695                 700                 


Val Ala Ala Thr Ser Cys Glu Gly Ile Glu Ser Val Ser Thr Pro Asn 
705                 710                 715                 720 


Glu Ser Val Val Asp Leu Val Ile Ser Ile Asn His Asn Trp Cys Asn 
                725                 730                 735     


Glu Trp Cys Val Glu Arg Met Val Asp Ala Phe Cys Arg Asp Ala Asn 
            740                 745                 750         


Arg Leu Trp Met Leu Leu Gly Asp Glu Val Arg Leu Thr Leu Phe Gly 
        755                 760                 765             


Asp Asp Val Gly Ala Trp His Asp His Val Glu Asn Leu Leu Met Gly 
    770                 775                 780                 


Gly Thr Asn Trp Asn Phe Gly Cys Ile Arg Ser Phe Leu Val Tyr Arg 
785                 790                 795                 800 


Leu Gln Val Leu Arg Ser Ser Gly Pro Thr Thr Ala Glu Gly Asp Asn 
                805                 810                 815     


Val Arg Arg Leu Ile Glu Leu Cys Leu Gly Lys Val Asn Glu Thr Glu 
            820                 825                 830         


Met Arg Val Ala His Cys Val Arg Gly 
        835                 840     


<210>  12
<211>  550
<212>  PRT
<213>  artificial sequence

<220>
<223>  Engineered Point Mutation

<400>  12

Met Ala Gln Ser Trp Phe Lys Arg His Pro Leu Gly Ile Tyr Pro Arg 
1               5                   10                  15      


Gly Asn Ala Lys Asn Leu Asp Glu Leu Val Ser Pro Arg Phe Gly Ile 
            20                  25                  30          


Leu Ser Thr Leu Gln Phe Ala Ser Lys Gly Arg Ala Gly Lys Cys Cys 
        35                  40                  45              


Ile Leu Gly Ser Gln Pro Ala Glu Glu Ala Phe Val Asp Val Met Leu 
    50                  55                  60                  


His Leu Leu Ser Phe Val Ala Val Asp Asp Met Cys Arg Leu Ser Ala 
65                  70                  75                  80  


Val Cys Thr Gly Trp Tyr Cys Phe Ile His Ala Ser Asp Ala Phe Lys 
                85                  90                  95      


Gln Ala His Gly Leu Leu Ser Pro Thr Tyr Thr Cys Phe Glu Gly Ser 
            100                 105                 110         


Trp Lys Glu Thr Ala Ile Arg Arg Phe Ile Lys Leu Arg Ser Lys Gln 
        115                 120                 125             


Arg Leu Asn Thr Ala Lys Arg Met Arg Leu Glu Gly Gly Thr Pro Gly 
    130                 135                 140                 


Val Gly Glu Thr Val Asn Leu Ser His Arg Pro Val Met Val Lys Arg 
145                 150                 155                 160 


Ala Phe Tyr Asn Asp Gln Leu Phe Gln Ala Trp Met Cys Thr Ile Leu 
                165                 170                 175     


Pro Cys His Tyr His Leu Arg Gln Ser Ser Ile Ala Gly Thr Ala Thr 
            180                 185                 190         


Ala Asn Arg Gln Pro Ser Val Leu Ser Ala Arg Gly Arg Tyr Arg Ser 
        195                 200                 205             


Pro Leu Lys Glu Val Pro Arg Cys Ser Gly Leu Ser Val Asp Glu Phe 
    210                 215                 220                 


Arg Thr Arg Phe Glu Glu Thr Asn Leu Pro Val Ile Ile Ala Asp Val 
225                 230                 235                 240 


Ala Thr Glu Trp Pro Ile Tyr Lys Ile Leu Gln Glu Lys Phe Glu Asn 
                245                 250                 255     


Leu Ala Val Met Gln Lys Lys Leu Phe Arg Pro Gly Thr Arg Pro Asp 
            260                 265                 270         


Val Pro Met Cys Cys Glu His Thr Thr Met Ser Val Ala Asp Tyr Val 
        275                 280                 285             


Arg Tyr Ala Arg Asp Gln Thr Asp Glu Arg Pro Ile Tyr Leu Phe Asp 
    290                 295                 300                 


Ser Glu Phe Gly Thr Phe Met Asp Val Glu Ser Leu Tyr Thr Val Pro 
305                 310                 315                 320 


Glu Tyr Phe Ser Arg Asp Asp Phe Phe Lys Val Leu Gly Gly Ala Arg 
                325                 330                 335     


Pro Lys Tyr Arg Trp Ile Ile Ala Gly Pro Arg Arg Gly Gly Ser Ser 
            340                 345                 350         


Phe Ala Val Asp Pro Asn Tyr Thr Ser Ala Trp Asn Ala Asn Leu Thr 
        355                 360                 365             


Gly Leu Lys Arg Trp Ile Leu Leu Pro Pro Gly His Thr Pro Ala Gly 
    370                 375                 380                 


Val Phe Pro Ser Glu Asp Met Ser Glu Val Val Thr Pro Val Ser Leu 
385                 390                 395                 400 


Thr Glu Trp Leu Leu Asn His Tyr Asp Ala Thr Val Glu Lys Trp Arg 
                405                 410                 415     


Asp Val Ala Tyr Glu Cys Val Cys Gly Pro Gly Asp Ile Met Phe Ile 
            420                 425                 430         


Pro Cys Gly Trp Trp His Phe Val Ile Asn Leu Glu Asp Ser Val Ala 
        435                 440                 445             


Ile Thr Gln Asn Tyr Val Ser Lys Cys Asn Leu Ser Ser Val Leu Lys 
    450                 455                 460                 


Phe Leu Ser Val Met Lys Ser Ser Ile Ser Gly Ile Asp Glu Asp Val 
465                 470                 475                 480 


Asp Asn Cys Asp Thr Ser Arg Met Val Glu Thr Arg Arg Ala Asn Phe 
                485                 490                 495     


Ala Glu Glu Phe Ala Ala Ala Met His Leu Ser Tyr Pro Glu Leu Met 
            500                 505                 510         


Gln Thr Val Ala Gly Glu Ala Lys Arg Glu Ala Glu Glu Arg His Glu 
        515                 520                 525             


Lys Lys Lys Met Arg Ala Ala Leu Pro Leu Leu Asp Val Gly Ser Asn 
    530                 535                 540                 


Gly Phe Ala Phe Ser Phe 
545                 550 


<210>  13
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  Engineered Point Mutation

<400>  13

Met Leu Glu Leu Asp Gly Arg Thr Leu Thr Phe Glu Gln Phe Arg Glu 
1               5                   10                  15      


Cys Cys Leu Lys Pro Asn Leu Pro Ala Ile Ile Arg His Ala Ala Val 
            20                  25                  30          


Asp Ser Thr Thr Asn Ser Val Gly Gly Ser Gly Pro Ser Pro Tyr Phe 
        35                  40                  45              


Ser Pro Leu Gly Asp Met Gln Ser His Leu Ser Pro Ile Gly Val Val 
    50                  55                  60                  


Asn Leu Phe Gly Gly Asp His Val Val Pro Ala Thr Glu Ser Pro Ala 
65                  70                  75                  80  


Thr Val Ala Ser Asp Ser Leu Lys Asp Gly Ile Ser Glu Gly His Met 
                85                  90                  95      


Lys Cys Ser Lys Leu Arg Leu Phe Glu Val Ile Glu Arg Trp Arg Gly 
            100                 105                 110         


Ser Pro Thr Leu Val Tyr Val Lys Asp Trp His Met Gln Ser Asp Leu 
        115                 120                 125             


Glu Ala Val Ser Ser Cys Val Gly Ala Pro Asp Leu Arg Gly Val Ser 
    130                 135                 140                 


Ser Val Val Ala Ser Asp Ala Glu Glu Gly Asn Ala Ala Val Cys Asn 
145                 150                 155                 160 


Gly Arg Arg Ala Val Val His Gly Gly Asn Leu Tyr Cys Val Pro Cys 
                165                 170                 175     


Tyr Leu Gly Pro Asp Trp Met Asp Glu Phe Cys Arg Phe Ser Gln His 
            180                 185                 190         


Gly Asp Ser Lys Tyr Arg Tyr Phe Gly Glu Glu Glu Ser Asp Tyr Arg 
        195                 200                 205             


Phe Ala Tyr Ile Gly Pro Pro Arg Ser Trp Thr Pro Leu Ala Phe Asp 
    210                 215                 220                 


Val Phe Gly Thr Tyr Ser Trp Ser Leu Asn Val Cys Gly Glu Lys Leu 
225                 230                 235                 240 


Trp Phe Phe Pro Thr Pro Glu Gly Asn Gln Thr Leu Leu Arg Gly Gly 
                245                 250                 255     


Leu His Gly Val Ala Leu Ala Pro Asp Ile Arg Thr Thr Ala Gly Ala 
            260                 265                 270         


Glu Leu Trp Thr Val Thr Gln Tyr Pro Gly Asp Leu Val Phe Val Pro 
        275                 280                 285             


Ser Cys Tyr Leu His Gln Val His Asn Val Lys Gly Ser Cys Phe Thr 
    290                 295                 300                 


Leu Pro Gln Thr Arg Glu Thr Ala Asn Val Ala Ala Thr Ser Cys Glu 
305                 310                 315                 320 


Gly Ile Glu Ser Val Ser Thr Pro Asn Glu Ser Val Val Asp Leu Val 
                325                 330                 335     


Ile Ser Ile Asn His Asn Trp Cys Asn Glu Trp Cys Val Glu Arg Met 
            340                 345                 350         


Val Asp Ala Phe Cys Arg Asp Ala Asn Arg Leu Trp Met Leu Leu Gly 
        355                 360                 365             


Asp Glu Val Arg Leu Thr Leu Phe Gly Asp Asp Val Gly Ala Trp His 
    370                 375                 380                 


Asp His Val Glu Asn Leu Leu Met Gly Gly Thr Asn Trp Asn Phe Gly 
385                 390                 395                 400 


Cys Ile Arg Ser Phe Leu Val Tyr Arg Leu Gln Val Leu Arg Ser Ser 
                405                 410                 415     


Gly Pro Thr Thr Ala Glu Gly Asp Asn Val Arg Arg Leu Ile Glu Leu 
            420                 425                 430         


Cys Leu Gly Lys Val Asn Glu Thr Glu Met Arg Val Ala His Cys Val 
        435                 440                 445             


Arg Gly 
    450 


<210>  14
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Peptide

<400>  14

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
1               5                   10                  15  


<210>  15
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Peptide

<400>  15

Gly Arg Gly Arg Gly Arg Gly 
1               5           


