                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       HANNA, Yaqub
       NOVERSHTERN, Noa
       RAIS, Yoach
 
<120>  MEDIA FOR CULTURING PLURIPOTENT STEM CELLS

<130>  62487

<150>  US 62/030,792
<151>  2014-07-30

<150>  US 62/167,469
<151>  2015-05-28

<160>  222   

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
ggtaccggat actcaggcca ggcccagaaa                                        30


<210>  2
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ctcgagtcca cagacctctg gcact                                             25


<210>  3
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ggtacccatt gagtccaaat cctctttact aggtg                                  35


<210>  4
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
ctcgagctga ggctcatgct gctgg                                             25


<210>  5
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp Lys 
1               5                   10                  15      


Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser Asp 
            20                  25                  30          


Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val Glu 
        35                  40                  45              


Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp Phe 
    50                  55                  60                  


Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val Ala 
65                  70                  75                  80  


Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr Arg 
                85                  90                  95      


Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala Pro 
            100                 105                 110         


Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe Pro 
        115                 120                 125             


Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp Gly 
    130                 135                 140                 


Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala Gln 
145                 150                 155                 160 


Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Arg Val Gly Cys 
                165                 170                 175     


Gly Glu Cys Ala Ala Cys Gln Val Thr Glu Asp Cys Gly Ala Cys Ser 
            180                 185                 190         


Thr Cys Leu Leu Gln Leu Pro His Asp Val Ala Ser Gly Leu Phe Cys 
        195                 200                 205             


Lys Cys Glu Arg Arg Arg Cys Leu Arg Ile Val Glu Arg Ser Arg Gly 
    210                 215                 220                 


Cys Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys 
225                 230                 235                 240 


Pro Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys 
                245                 250                 255     


Cys Val Gln Arg Arg Cys Leu Arg Gly Lys His Ala Arg Arg Lys Gly 
            260                 265                 270         


Gly Cys Asp Ser Lys Met Ala Ala Arg Arg Arg Pro Gly Ala Gln Pro 
        275                 280                 285             


Leu Pro Pro Pro Pro Pro Ser Gln Ser Pro Glu Pro Thr Glu Pro His 
    290                 295                 300                 


Pro Arg Ala Leu Ala Pro Ser Pro Pro Ala Glu Phe Ile Tyr Tyr Cys 
305                 310                 315                 320 


Val Asp Glu Asp Glu Leu Gln Pro Tyr Thr Asn Arg Arg Gln Asn Arg 
                325                 330                 335     


Lys Cys Gly Ala Cys Ala Ala Cys Leu Arg Arg Met Asp Cys Gly Arg 
            340                 345                 350         


Cys Asp Phe Cys Cys Asp Lys Pro Lys Phe Gly Gly Ser Asn Gln Lys 
        355                 360                 365             


Arg Gln Lys Cys Arg Trp Arg Gln Cys Leu Gln Phe Ala Met Lys Arg 
    370                 375                 380                 


Leu Leu Pro Ser Val Trp Ser Glu Ser Glu Asp Gly Ala Gly Ser Pro 
385                 390                 395                 400 


Pro Pro Tyr Arg Arg Arg Lys Arg Pro Ser Ser Ala Arg Arg His His 
                405                 410                 415     


Leu Gly Pro Thr Leu Lys Pro Thr Leu Ala Thr Arg Thr Ala Gln Pro 
            420                 425                 430         


Asp His Thr Gln Ala Pro Thr Lys Gln Glu Ala Gly Gly Gly Phe Val 
        435                 440                 445             


Leu Pro Pro Pro Gly Thr Asp Leu Val Phe Leu Arg Glu Gly Ala Ser 
    450                 455                 460                 


Ser Pro Val Gln Val Pro Gly Pro Val Ala Ala Ser Thr Glu Ala Leu 
465                 470                 475                 480 


Leu Gln Glu Ala Gln Cys Ser Gly Leu Ser Trp Val Val Ala Leu Pro 
                485                 490                 495     


Gln Val Lys Gln Glu Lys Ala Asp Thr Gln Asp Glu Trp Thr Pro Gly 
            500                 505                 510         


Thr Ala Val Leu Thr Ser Pro Val Leu Val Pro Gly Cys Pro Ser Lys 
        515                 520                 525             


Ala Val Asp Pro Gly Leu Pro Ser Val Lys Gln Glu Pro Pro Asp Pro 
    530                 535                 540                 


Glu Glu Asp Lys Glu Glu Asn Lys Asp Asp Ser Ala Ser Lys Leu Ala 
545                 550                 555                 560 


Pro Glu Glu Glu Ala Gly Gly Ala Gly Thr Pro Val Ile Thr Glu Ile 
                565                 570                 575     


Phe Ser Leu Gly Gly Thr Arg Phe Arg Asp Thr Ala Val Trp Leu Pro 
            580                 585                 590         


Arg Ser Lys Asp Leu Lys Lys Pro Gly Ala Arg Lys Gln 
        595                 600                 605 


<210>  6
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ala His Pro Gly Gly Gly Arg Cys Cys Pro Glu Gln Glu Glu 
1               5                   10                  15      


Gly Glu Ser Ala Ala Gly Gly Ser Gly Ala Gly Gly Asp Ser Ala Ile 
            20                  25                  30          


Glu Gln Gly Gly Gln Gly Ser Ala Leu Ala Pro Ser Pro Val Ser Gly 
        35                  40                  45              


Val Arg Arg Glu Gly Ala Arg Gly Gly Gly Arg Gly Arg Gly Arg Trp 
    50                  55                  60                  


Lys Gln Ala Gly Arg Gly Gly Gly Val Cys Gly Arg Gly Arg Gly Arg 
65                  70                  75                  80  


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
                85                  90                  95      


Pro Pro Ser Gly Gly Ser Gly Leu Gly Gly Asp Gly Gly Gly Cys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ala Pro Arg Arg Glu Pro Val Pro 
        115                 120                 125             


Phe Pro Ser Gly Ser Ala Gly Pro Gly Pro Arg Gly Pro Arg Ala Thr 
    130                 135                 140                 


Glu Ser Gly Lys Arg Met Asp Cys Pro Ala Leu Pro Pro Gly Trp Lys 
145                 150                 155                 160 


Lys Glu Glu Val Ile Arg Lys Ser Gly Leu Ser Ala Gly Lys Ser Asp 
                165                 170                 175     


Val Tyr Tyr Phe Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
            180                 185                 190         


Leu Ala Arg Tyr Leu Gly Asn Thr Val Asp Leu Ser Ser Phe Asp Phe 
        195                 200                 205             


Arg Thr Gly Lys Met Met Pro Ser Lys Leu Gln Lys Asn Lys Gln Arg 
    210                 215                 220                 


Leu Arg Asn Asp Pro Leu Asn Gln Asn Lys Gly Lys Pro Asp Leu Asn 
225                 230                 235                 240 


Thr Thr Leu Pro Ile Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
                245                 250                 255     


Thr Lys Val Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
            260                 265                 270         


Arg Met Asn Glu Gln Pro Arg Gln Leu Phe Trp Glu Lys Arg Leu Gln 
        275                 280                 285             


Gly Leu Ser Ala Ser Asp Val Thr Glu Gln Ile Ile Lys Thr Met Glu 
    290                 295                 300                 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Ser Asn Asp Glu Thr 
305                 310                 315                 320 


Leu Leu Ser Ala Val Ala Ser Ala Leu His Thr Ser Ser Ala Pro Ile 
                325                 330                 335     


Thr Gly Gln Val Ser Ala Ala Val Glu Lys Asn Pro Ala Val Trp Leu 
            340                 345                 350         


Asn Thr Ser Gln Pro Leu Cys Lys Ala Phe Ile Val Thr Asp Glu Asp 
        355                 360                 365             


Ile Arg Lys Gln Glu Glu Arg Val Gln Gln Val Arg Lys Lys Leu Glu 
    370                 375                 380                 


Glu Ala Leu Met Ala Asp Ile Leu Ser Arg Ala Ala Asp Thr Glu Glu 
385                 390                 395                 400 


Met Asp Ile Glu Met Asp Ser Gly Asp Glu Ala 
                405                 410     


<210>  7
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Arg Lys Arg Trp Glu Cys Pro Ala Leu Pro Gln Gly Trp Glu 
1               5                   10                  15      


Arg Glu Glu Val Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp 
            20                  25                  30          


Val Phe Tyr Tyr Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
        35                  40                  45              


Leu Ala Arg Tyr Leu Gly Gly Ser Met Asp Leu Ser Thr Phe Asp Phe 
    50                  55                  60                  


Arg Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg 
65                  70                  75                  80  


Val Arg Tyr Asp Ser Ser Asn Gln Val Lys Gly Lys Pro Asp Leu Asn 
                85                  90                  95      


Thr Ala Leu Pro Val Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
            100                 105                 110         


Thr Lys Ile Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
        115                 120                 125             


Lys Ala Val Asp Gln Pro Arg Gln Leu Phe Trp Glu Lys Lys Leu Ser 
    130                 135                 140                 


Gly Leu Asn Ala Phe Asp Ile Ala Glu Glu Leu Val Lys Thr Met Asp 
145                 150                 155                 160 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Cys Thr Asp Glu Thr 
                165                 170                 175     


Leu Leu Ser Ala Ile Ala Ser Ala Leu His Thr Ser Thr Met Pro Ile 
            180                 185                 190         


Thr Gly Gln Leu Ser Ala Ala Val Glu Lys Asn Pro Gly Val Trp Leu 
        195                 200                 205             


Asn Thr Thr Gln Pro Leu Cys Lys Ala Phe Met Val Thr Asp Glu Asp 
    210                 215                 220                 


Ile Arg Lys Gln Glu Glu Leu Val Gln Gln Val Arg Lys Arg Leu Glu 
225                 230                 235                 240 


Glu Ala Leu Met Ala Asp Met Leu Ala His Val Glu Glu Leu Ala Arg 
                245                 250                 255     


Asp Gly Glu Ala Pro Leu Asp Lys Ala Cys Ala Glu Asp Asp Asp Glu 
            260                 265                 270         


Glu Asp Glu Glu Glu Glu Glu Glu Glu Pro Asp Pro Asp Pro Glu Met 
        275                 280                 285             


Glu His Val 
    290     


<210>  8
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Thr Thr Gly Leu Glu Ser Leu Ser Leu Gly Asp Arg Gly Ala 
1               5                   10                  15      


Ala Pro Thr Val Thr Ser Ser Glu Arg Leu Val Pro Asp Pro Pro Asn 
            20                  25                  30          


Asp Leu Arg Lys Glu Asp Val Ala Met Glu Leu Glu Arg Val Gly Glu 
        35                  40                  45              


Asp Glu Glu Gln Met Met Ile Lys Arg Ser Ser Glu Cys Asn Pro Leu 
    50                  55                  60                  


Leu Gln Glu Pro Ile Ala Ser Ala Gln Phe Gly Ala Thr Ala Gly Thr 
65                  70                  75                  80  


Glu Cys Arg Lys Ser Val Pro Cys Gly Trp Glu Arg Val Val Lys Gln 
                85                  90                  95      


Arg Leu Phe Gly Lys Thr Ala Gly Arg Phe Asp Val Tyr Phe Ile Ser 
            100                 105                 110         


Pro Gln Gly Leu Lys Phe Arg Ser Lys Ser Ser Leu Ala Asn Tyr Leu 
        115                 120                 125             


His Lys Asn Gly Glu Thr Ser Leu Lys Pro Glu Asp Phe Asp Phe Thr 
    130                 135                 140                 


Val Leu Ser Lys Arg Gly Ile Lys Ser Arg Tyr Lys Asp Cys Ser Met 
145                 150                 155                 160 


Ala Ala Leu Thr Ser His Leu Gln Asn Gln Ser Asn Asn Ser Asn Trp 
                165                 170                 175     


Asn Leu Arg Thr Arg Ser Lys Cys Lys Lys Asp Val Phe Met Pro Pro 
            180                 185                 190         


Ser Ser Ser Ser Glu Leu Gln Glu Ser Arg Gly Leu Ser Asn Phe Thr 
        195                 200                 205             


Ser Thr His Leu Leu Leu Lys Glu Asp Glu Gly Val Asp Asp Val Asn 
    210                 215                 220                 


Phe Arg Lys Val Arg Lys Pro Lys Gly Lys Val Thr Ile Leu Lys Gly 
225                 230                 235                 240 


Ile Pro Ile Lys Lys Thr Lys Lys Gly Cys Arg Lys Ser Cys Ser Gly 
                245                 250                 255     


Phe Val Gln Ser Asp Ser Lys Arg Glu Ser Val Cys Asn Lys Ala Asp 
            260                 265                 270         


Ala Glu Ser Glu Pro Val Ala Gln Lys Ser Gln Leu Asp Arg Thr Val 
        275                 280                 285             


Cys Ile Ser Asp Ala Gly Ala Cys Gly Glu Thr Leu Ser Val Thr Ser 
    290                 295                 300                 


Glu Glu Asn Ser Leu Val Lys Lys Lys Glu Arg Ser Leu Ser Ser Gly 
305                 310                 315                 320 


Ser Asn Phe Cys Ser Glu Gln Lys Thr Ser Gly Ile Ile Asn Lys Phe 
                325                 330                 335     


Cys Ser Ala Lys Asp Ser Glu His Asn Glu Lys Tyr Glu Asp Thr Phe 
            340                 345                 350         


Leu Glu Ser Glu Glu Ile Gly Thr Lys Val Glu Val Val Glu Arg Lys 
        355                 360                 365             


Glu His Leu His Thr Asp Ile Leu Lys Arg Gly Ser Glu Met Asp Asn 
    370                 375                 380                 


Asn Cys Ser Pro Thr Arg Lys Asp Phe Thr Gly Glu Lys Ile Phe Gln 
385                 390                 395                 400 


Glu Asp Thr Ile Pro Arg Thr Gln Ile Glu Arg Arg Lys Thr Ser Leu 
                405                 410                 415     


Tyr Phe Ser Ser Lys Tyr Asn Lys Glu Ala Leu Ser Pro Pro Arg Arg 
            420                 425                 430         


Lys Ala Phe Lys Lys Trp Thr Pro Pro Arg Ser Pro Phe Asn Leu Val 
        435                 440                 445             


Gln Glu Thr Leu Phe His Asp Pro Trp Lys Leu Leu Ile Ala Thr Ile 
    450                 455                 460                 


Phe Leu Asn Arg Thr Ser Gly Lys Met Ala Ile Pro Val Leu Trp Lys 
465                 470                 475                 480 


Phe Leu Glu Lys Tyr Pro Ser Ala Glu Val Ala Arg Thr Ala Asp Trp 
                485                 490                 495     


Arg Asp Val Ser Glu Leu Leu Lys Pro Leu Gly Leu Tyr Asp Leu Arg 
            500                 505                 510         


Ala Lys Thr Ile Val Lys Phe Ser Asp Glu Tyr Leu Thr Lys Gln Trp 
        515                 520                 525             


Lys Tyr Pro Ile Glu Leu His Gly Ile Gly Lys Tyr Gly Asn Asp Ser 
    530                 535                 540                 


Tyr Arg Ile Phe Cys Val Asn Glu Trp Lys Gln Val His Pro Glu Asp 
545                 550                 555                 560 


His Lys Leu Asn Lys Tyr His Asp Trp Leu Trp Glu Asn His Glu Lys 
                565                 570                 575     


Leu Ser Leu Ser 
            580 


<210>  9
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  10
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  11
<211>  1912
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Thr Glu Thr 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg 
65                  70                  75                  80  


Gln Leu Gly Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu 
                85                  90                  95      


Glu Glu Val Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Thr Pro 
            100                 105                 110         


Gly Lys Lys Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser 
        115                 120                 125             


Lys Ser Lys Arg Lys Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp 
    130                 135                 140                 


Ser Lys Glu Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met 
145                 150                 155                 160 


Glu Asp Ile Asp His Val Phe Ser Glu Glu Asp Tyr Arg Thr Leu Thr 
                165                 170                 175     


Asn Tyr Lys Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys 
            180                 185                 190         


Asn Pro Lys Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys 
        195                 200                 205             


Trp Arg Glu Phe Ser Thr Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala 
    210                 215                 220                 


Ser Val Ala Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met 
225                 230                 235                 240 


Val Thr Ala Thr Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro 
                245                 250                 255     


Ile Arg Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg 
            260                 265                 270         


Lys Pro Lys Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro 
        275                 280                 285             


Lys Lys Val Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys 
    290                 295                 300                 


Arg Lys Arg Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp 
305                 310                 315                 320 


Phe Asp Asp Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Thr 
                325                 330                 335     


Ser Arg Ser Ser Arg Ser Arg Lys Lys Leu Arg Thr Thr Lys Lys Lys 
            340                 345                 350         


Lys Lys Gly Glu Glu Glu Val Thr Ala Val Asp Gly Tyr Glu Thr Asp 
        355                 360                 365             


His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile Leu 
    370                 375                 380                 


Cys Asp Thr Cys Pro Arg Ala Tyr His Met Val Cys Leu Asp Pro Asp 
385                 390                 395                 400 


Met Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu Lys 
                405                 410                 415     


Glu Gly Ile Gln Trp Glu Ala Lys Glu Asp Asn Ser Glu Gly Glu Glu 
            420                 425                 430         


Ile Leu Glu Glu Val Gly Gly Asp Leu Glu Glu Glu Asp Asp His His 
        435                 440                 445             


Met Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys 
    450                 455                 460                 


Asp Thr Cys Pro Ser Ser Tyr His Ile His Cys Leu Asn Pro Pro Leu 
465                 470                 475                 480 


Pro Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro 
                485                 490                 495     


Ala Leu Lys Gly Lys Val Gln Lys Ile Leu Ile Trp Lys Trp Gly Gln 
            500                 505                 510         


Pro Pro Ser Pro Thr Pro Val Pro Arg Pro Pro Asp Ala Asp Pro Asn 
        515                 520                 525             


Thr Pro Ser Pro Lys Pro Leu Glu Gly Arg Pro Glu Arg Gln Phe Phe 
    530                 535                 540                 


Val Lys Trp Gln Gly Met Ser Tyr Trp His Cys Ser Trp Val Ser Glu 
545                 550                 555                 560 


Leu Gln Leu Glu Leu His Cys Gln Val Met Phe Arg Asn Tyr Gln Arg 
                565                 570                 575     


Lys Asn Asp Met Asp Glu Pro Pro Ser Gly Asp Phe Gly Gly Asp Glu 
            580                 585                 590         


Glu Lys Ser Arg Lys Arg Lys Asn Lys Asp Pro Lys Phe Ala Glu Met 
        595                 600                 605             


Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile 
    610                 615                 620                 


His Arg Ile Leu Asn His Ser Val Asp Lys Lys Gly His Val His Tyr 
625                 630                 635                 640 


Leu Ile Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ala Ser Trp Glu Ser 
                645                 650                 655     


Glu Asp Val Glu Ile Gln Asp Tyr Asp Leu Phe Lys Gln Ser Tyr Trp 
            660                 665                 670         


Asn His Arg Glu Leu Met Arg Gly Glu Glu Gly Arg Pro Gly Lys Lys 
        675                 680                 685             


Leu Lys Lys Val Lys Leu Arg Lys Leu Glu Arg Pro Pro Glu Thr Pro 
    690                 695                 700                 


Thr Val Asp Pro Thr Val Lys Tyr Glu Arg Gln Pro Glu Tyr Leu Asp 
705                 710                 715                 720 


Ala Thr Gly Gly Thr Leu His Pro Tyr Gln Met Glu Gly Leu Asn Trp 
                725                 730                 735     


Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu 
            740                 745                 750         


Met Gly Leu Gly Lys Thr Val Gln Thr Ala Val Phe Leu Tyr Ser Leu 
        755                 760                 765             


Tyr Lys Glu Gly His Ser Lys Gly Pro Phe Leu Val Ser Ala Pro Leu 
    770                 775                 780                 


Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp 
785                 790                 795                 800 


Met Tyr Val Val Thr Tyr Val Gly Asp Lys Asp Ser Arg Ala Ile Ile 
                805                 810                 815     


Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Gly Gly Lys 
            820                 825                 830         


Lys Ala Ser Arg Met Lys Lys Glu Ala Ser Val Lys Phe His Val Leu 
        835                 840                 845             


Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp Met Ala Ile Leu Gly Ser 
    850                 855                 860                 


Ile Asp Trp Ala Cys Leu Ile Val Asp Glu Ala His Arg Leu Lys Asn 
865                 870                 875                 880 


Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly Tyr Ser Leu Gln His 
                885                 890                 895     


Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu 
            900                 905                 910         


Phe His Leu Leu Asn Phe Leu Thr Pro Glu Arg Phe His Asn Leu Glu 
        915                 920                 925             


Gly Phe Leu Glu Glu Phe Ala Asp Ile Ala Lys Glu Asp Gln Ile Lys 
    930                 935                 940                 


Lys Leu His Asp Met Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala 
945                 950                 955                 960 


Asp Val Phe Lys Asn Met Pro Ser Lys Thr Glu Leu Ile Val Arg Val 
                965                 970                 975     


Glu Leu Ser Pro Met Gln Lys Lys Tyr Tyr Lys Tyr Ile Leu Thr Arg 
            980                 985                 990         


Asn Phe Glu Ala Leu Asn Ala Arg  Gly Gly Gly Asn Gln  Val Ser Leu 
        995                 1000                 1005             


Leu Asn  Val Val Met Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr 
    1010                 1015                 1020             


Leu Phe  Pro Val Ala Ala Met  Glu Ala Pro Lys Met  Pro Asn Gly 
    1025                 1030                 1035             


Met Tyr  Asp Gly Ser Ala Leu  Ile Arg Ala Ser Gly  Lys Leu Leu 
    1040                 1045                 1050             


Leu Leu  Gln Lys Met Leu Lys  Asn Leu Lys Glu Gly  Gly His Arg 
    1055                 1060                 1065             


Val Leu  Ile Phe Ser Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu 
    1070                 1075                 1080             


Asp Phe  Leu Glu His Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly 
    1085                 1090                 1095             


Gly Ile  Thr Gly Asn Met Arg  Gln Glu Ala Ile Asp  Arg Phe Asn 
    1100                 1105                 1110             


Ala Pro  Gly Ala Gln Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Ile Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile 
    1130                 1135                 1140             


Tyr Asp  Ser Asp Trp Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Asn Lys Lys Val Met  Ile Tyr Arg 
    1160                 1165                 1170             


Phe Val  Thr Arg Ala Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala 
    1175                 1180                 1185             


Lys Lys  Lys Met Met Leu Thr  His Leu Val Val Arg  Pro Gly Leu 
    1190                 1195                 1200             


Gly Ser  Lys Thr Gly Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile 
    1205                 1210                 1215             


Leu Lys  Phe Gly Thr Glu Glu  Leu Phe Lys Asp Glu  Ala Thr Asp 
    1220                 1225                 1230             


Gly Gly  Gly Asp Asn Lys Glu  Gly Glu Asp Ser Ser  Val Ile His 
    1235                 1240                 1245             


Tyr Asp  Asp Lys Ala Ile Glu  Arg Leu Leu Asp Arg  Asn Gln Asp 
    1250                 1255                 1260             


Glu Thr  Glu Asp Thr Glu Leu  Gln Gly Met Asn Glu  Tyr Leu Ser 
    1265                 1270                 1275             


Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg Glu Glu  Glu Met Gly 
    1280                 1285                 1290             


Glu Glu  Glu Glu Val Glu Arg  Glu Ile Ile Lys Gln  Glu Glu Ser 
    1295                 1300                 1305             


Val Asp  Pro Asp Tyr Trp Glu  Lys Leu Leu Arg His  His Tyr Glu 
    1310                 1315                 1320             


Gln Gln  Gln Glu Asp Leu Ala  Arg Asn Leu Gly Lys  Gly Lys Arg 
    1325                 1330                 1335             


Ile Arg  Lys Gln Val Asn Tyr  Asn Asp Gly Ser Gln  Glu Asp Arg 
    1340                 1345                 1350             


Asp Trp  Gln Asp Asp Gln Ser  Asp Asn Gln Ser Asp  Tyr Ser Val 
    1355                 1360                 1365             


Ala Ser  Glu Glu Gly Asp Glu  Asp Phe Asp Glu Arg  Ser Glu Ala 
    1370                 1375                 1380             


Pro Arg  Arg Pro Ser Arg Lys  Gly Leu Arg Asn Asp  Lys Asp Lys 
    1385                 1390                 1395             


Pro Leu  Pro Pro Leu Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val 
    1400                 1405                 1410             


Leu Gly  Phe Asn Ala Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Ile 
    1415                 1420                 1425             


Met Arg  Tyr Gly Met Pro Pro  Gln Asp Ala Phe Thr  Thr Gln Trp 
    1430                 1435                 1440             


Leu Val  Arg Asp Leu Arg Gly  Lys Ser Glu Lys Glu  Phe Lys Ala 
    1445                 1450                 1455             


Tyr Val  Ser Leu Phe Met Arg  His Leu Cys Glu Pro  Gly Ala Asp 
    1460                 1465                 1470             


Gly Ala  Glu Thr Phe Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser 
    1475                 1480                 1485             


Arg Gln  His Val Leu Thr Arg  Ile Gly Val Met Ser  Leu Ile Arg 
    1490                 1495                 1500             


Lys Lys  Val Gln Glu Phe Glu  His Val Asn Gly Arg  Trp Ser Met 
    1505                 1510                 1515             


Pro Glu  Leu Ala Glu Val Glu  Glu Asn Lys Lys Met  Ser Gln Pro 
    1520                 1525                 1530             


Gly Ser  Pro Ser Pro Lys Thr  Pro Thr Pro Ser Thr  Pro Gly Asp 
    1535                 1540                 1545             


Thr Gln  Pro Asn Thr Pro Ala  Pro Val Pro Pro Ala  Glu Asp Gly 
    1550                 1555                 1560             


Ile Lys  Ile Glu Glu Asn Ser  Leu Lys Glu Glu Glu  Ser Ile Glu 
    1565                 1570                 1575             


Gly Glu  Lys Glu Val Lys Ser  Thr Ala Pro Glu Thr  Ala Ile Glu 
    1580                 1585                 1590             


Cys Thr  Gln Ala Pro Ala Pro  Ala Ser Glu Asp Glu  Lys Val Val 
    1595                 1600                 1605             


Val Glu  Pro Pro Glu Gly Glu  Glu Lys Val Glu Lys  Ala Glu Val 
    1610                 1615                 1620             


Lys Glu  Arg Thr Glu Glu Pro  Met Glu Thr Glu Pro  Lys Gly Ala 
    1625                 1630                 1635             


Ala Asp  Val Glu Lys Val Glu  Glu Lys Ser Ala Ile  Asp Leu Thr 
    1640                 1645                 1650             


Pro Ile  Val Val Glu Asp Lys  Glu Glu Lys Lys Glu  Glu Glu Glu 
    1655                 1660                 1665             


Lys Lys  Glu Val Met Leu Gln  Asn Gly Glu Thr Pro  Lys Asp Leu 
    1670                 1675                 1680             


Asn Asp  Glu Lys Gln Lys Lys  Asn Ile Lys Gln Arg  Phe Met Phe 
    1685                 1690                 1695             


Asn Ile  Ala Asp Gly Gly Phe  Thr Glu Leu His Ser  Leu Trp Gln 
    1700                 1705                 1710             


Asn Glu  Glu Arg Ala Ala Thr  Val Thr Lys Lys Thr  Tyr Glu Ile 
    1715                 1720                 1725             


Trp His  Arg Arg His Asp Tyr  Trp Leu Leu Ala Gly  Ile Ile Asn 
    1730                 1735                 1740             


His Gly  Tyr Ala Arg Trp Gln  Asp Ile Gln Asn Asp  Pro Arg Tyr 
    1745                 1750                 1755             


Ala Ile  Leu Asn Glu Pro Phe  Lys Gly Glu Met Asn  Arg Gly Asn 
    1760                 1765                 1770             


Phe Leu  Glu Ile Lys Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu 
    1775                 1780                 1785             


Leu Glu  Gln Ala Leu Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala 
    1790                 1795                 1800             


Tyr Leu  Asn Met Ser Glu Asp  Pro Ser His Pro Ser  Met Ala Leu 
    1805                 1810                 1815             


Asn Thr  Arg Phe Ala Glu Val  Glu Cys Leu Ala Glu  Ser His Gln 
    1820                 1825                 1830             


His Leu  Ser Lys Glu Ser Met  Ala Gly Asn Lys Pro  Ala Asn Ala 
    1835                 1840                 1845             


Val Leu  His Lys Val Leu Lys  Gln Leu Glu Glu Leu  Leu Ser Asp 
    1850                 1855                 1860             


Met Lys  Ala Asp Val Thr Arg  Leu Pro Ala Thr Ile  Ala Arg Ile 
    1865                 1870                 1875             


Pro Pro  Val Ala Val Arg Leu  Gln Met Ser Glu Arg  Asn Ile Leu 
    1880                 1885                 1890             


Ser Arg  Leu Ala Asn Arg Ala  Pro Glu Pro Thr Pro  Gln Gln Val 
    1895                 1900                 1905             


Ala Gln  Gln Gln 
    1910         


<210>  12
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  13
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Asp Lys Glu Ala Phe Asp Asp Ala Val Glu Glu Arg Val Ile 
1               5                   10                  15      


Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr Asp 
            20                  25                  30          


Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln Trp 
        35                  40                  45              


Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His Arg 
    50                  55                  60                  


Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val Ile 
65                  70                  75                  80  


Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser His 
                85                  90                  95      


Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser Gly 
            100                 105                 110         


Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn Arg 
        115                 120                 125             


Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr Pro 
    130                 135                 140                 


Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys Pro 
145                 150                 155                 160 


Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His Gln 
                165                 170                 175     


Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His Leu 
            180                 185                 190         


Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser Ala 
        195                 200                 205             


Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr Gly 
    210                 215                 220                 


His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu Ser 
225                 230                 235                 240 


Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp Thr 
                245                 250                 255     


Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His Thr 
            260                 265                 270         


Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile Leu 
        275                 280                 285             


Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg Asn 
    290                 295                 300                 


Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile Phe 
305                 310                 315                 320 


Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser Gly 
                325                 330                 335     


Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu Glu 
            340                 345                 350         


Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe Ile 
        355                 360                 365             


His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro Asn 
    370                 375                 380                 


Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln Val 
385                 390                 395                 400 


Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly Ser 
                405                 410                 415     


Val Asp Pro Glu Gly Gln Gly Ser 
            420                 


<210>  14
<211>  1792
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Cys Val His Tyr Lys Phe Ser Ser Lys Leu Asn Tyr Asp Thr 
1               5                   10                  15      


Val Thr Phe Asp Gly Leu His Ile Ser Leu Cys Asp Leu Lys Lys Gln 
            20                  25                  30          


Ile Met Gly Arg Glu Lys Leu Lys Ala Ala Asp Cys Asp Leu Gln Ile 
        35                  40                  45              


Thr Asn Ala Gln Thr Lys Glu Glu Tyr Thr Asp Asp Asn Ala Leu Ile 
    50                  55                  60                  


Pro Lys Asn Ser Ser Val Ile Val Arg Arg Ile Pro Ile Gly Gly Val 
65                  70                  75                  80  


Lys Ser Thr Ser Lys Thr Tyr Val Ile Ser Arg Thr Glu Pro Ala Met 
                85                  90                  95      


Ala Thr Thr Lys Ala Ile Asp Asp Ser Ser Ala Ser Ile Ser Leu Ala 
            100                 105                 110         


Gln Leu Thr Lys Thr Ala Asn Leu Ala Glu Ala Asn Ala Ser Glu Glu 
        115                 120                 125             


Asp Lys Ile Lys Ala Met Met Ser Gln Ser Gly His Glu Tyr Asp Pro 
    130                 135                 140                 


Ile Asn Tyr Met Lys Lys Pro Leu Gly Pro Pro Pro Pro Ser Tyr Thr 
145                 150                 155                 160 


Cys Phe Arg Cys Gly Lys Pro Gly His Tyr Ile Lys Asn Cys Pro Thr 
                165                 170                 175     


Asn Gly Asp Lys Asn Phe Glu Ser Gly Pro Arg Ile Lys Lys Ser Thr 
            180                 185                 190         


Gly Ile Pro Arg Ser Phe Met Met Glu Val Lys Asp Pro Asn Met Lys 
        195                 200                 205             


Gly Ala Met Leu Thr Asn Thr Gly Lys Tyr Ala Ile Pro Thr Ile Asp 
    210                 215                 220                 


Ala Glu Ala Tyr Ala Ile Gly Lys Lys Glu Lys Pro Pro Phe Leu Pro 
225                 230                 235                 240 


Glu Glu Pro Ser Ser Ser Ser Glu Glu Asp Asp Pro Ile Pro Asp Glu 
                245                 250                 255     


Leu Leu Cys Leu Ile Cys Lys Asp Ile Met Thr Asp Ala Val Val Ile 
            260                 265                 270         


Pro Cys Cys Gly Asn Ser Tyr Cys Asp Glu Cys Ile Arg Thr Ala Leu 
        275                 280                 285             


Leu Glu Ser Asp Glu His Thr Cys Pro Thr Cys His Gln Asn Asp Val 
    290                 295                 300                 


Ser Pro Asp Ala Leu Ile Ala Asn Lys Phe Leu Arg Gln Ala Val Asn 
305                 310                 315                 320 


Asn Phe Lys Asn Glu Thr Gly Tyr Thr Lys Arg Leu Arg Lys Gln Leu 
                325                 330                 335     


Pro Pro Pro Pro Pro Pro Ile Pro Pro Pro Arg Pro Leu Ile Gln Arg 
            340                 345                 350         


Asn Leu Gln Pro Leu Met Arg Ser Pro Ile Ser Arg Gln Gln Asp Pro 
        355                 360                 365             


Leu Met Ile Pro Val Thr Ser Ser Ser Thr His Pro Ala Pro Ser Ile 
    370                 375                 380                 


Ser Ser Leu Thr Ser Asn Gln Ser Ser Leu Ala Pro Pro Val Ser Gly 
385                 390                 395                 400 


Asn Pro Ser Ser Ala Pro Ala Pro Val Pro Asp Ile Thr Ala Thr Val 
                405                 410                 415     


Ser Ile Ser Val His Ser Glu Lys Ser Asp Gly Pro Phe Arg Asp Ser 
            420                 425                 430         


Asp Asn Lys Ile Leu Pro Ala Ala Ala Leu Ala Ser Glu His Ser Lys 
        435                 440                 445             


Gly Thr Ser Ser Ile Ala Ile Thr Ala Leu Met Glu Glu Lys Gly Tyr 
    450                 455                 460                 


Gln Val Pro Val Leu Gly Thr Pro Ser Leu Leu Gly Gln Ser Leu Leu 
465                 470                 475                 480 


His Gly Gln Leu Ile Pro Thr Thr Gly Pro Val Arg Ile Asn Thr Ala 
                485                 490                 495     


Arg Pro Gly Gly Gly Arg Pro Gly Trp Glu His Ser Asn Lys Leu Gly 
            500                 505                 510         


Tyr Leu Val Ser Pro Pro Gln Gln Ile Arg Arg Gly Glu Arg Ser Cys 
        515                 520                 525             


Tyr Arg Ser Ile Asn Arg Gly Arg His His Ser Glu Arg Ser Gln Arg 
    530                 535                 540                 


Thr Gln Gly Pro Ser Leu Pro Ala Thr Pro Val Phe Val Pro Val Pro 
545                 550                 555                 560 


Pro Pro Pro Leu Tyr Pro Pro Pro Pro His Thr Leu Pro Leu Pro Pro 
                565                 570                 575     


Gly Val Pro Pro Pro Gln Phe Ser Pro Gln Phe Pro Pro Gly Gln Pro 
            580                 585                 590         


Pro Pro Ala Gly Tyr Ser Val Pro Pro Pro Gly Phe Pro Pro Ala Pro 
        595                 600                 605             


Ala Asn Leu Ser Thr Pro Trp Val Ser Ser Gly Val Gln Thr Ala His 
    610                 615                 620                 


Ser Asn Thr Ile Pro Thr Thr Gln Ala Pro Pro Leu Ser Arg Glu Glu 
625                 630                 635                 640 


Phe Tyr Arg Glu Gln Arg Arg Leu Lys Glu Glu Glu Lys Lys Lys Ser 
                645                 650                 655     


Lys Leu Asp Glu Phe Thr Asn Asp Phe Ala Lys Glu Leu Met Glu Tyr 
            660                 665                 670         


Lys Lys Ile Gln Lys Glu Arg Arg Arg Ser Phe Ser Arg Ser Lys Ser 
        675                 680                 685             


Pro Tyr Ser Gly Ser Ser Tyr Ser Arg Ser Ser Tyr Thr Tyr Ser Lys 
    690                 695                 700                 


Ser Arg Ser Gly Ser Thr Arg Ser Arg Ser Tyr Ser Arg Ser Phe Ser 
705                 710                 715                 720 


Arg Ser His Ser Arg Ser Tyr Ser Arg Ser Pro Pro Tyr Pro Arg Arg 
                725                 730                 735     


Gly Arg Gly Lys Ser Arg Asn Tyr Arg Ser Arg Ser Arg Ser His Gly 
            740                 745                 750         


Tyr His Arg Ser Arg Ser Arg Ser Pro Pro Tyr Arg Arg Tyr His Ser 
        755                 760                 765             


Arg Ser Arg Ser Pro Gln Ala Phe Arg Gly Gln Ser Pro Asn Lys Arg 
    770                 775                 780                 


Asn Val Pro Gln Gly Glu Thr Glu Arg Glu Tyr Phe Asn Arg Tyr Arg 
785                 790                 795                 800 


Glu Val Pro Pro Pro Tyr Asp Met Lys Ala Tyr Tyr Gly Arg Ser Val 
                805                 810                 815     


Asp Phe Arg Asp Pro Phe Glu Lys Glu Arg Tyr Arg Glu Trp Glu Arg 
            820                 825                 830         


Lys Tyr Arg Glu Trp Tyr Glu Lys Tyr Tyr Lys Gly Tyr Ala Ala Gly 
        835                 840                 845             


Ala Gln Pro Arg Pro Ser Ala Asn Arg Glu Asn Phe Ser Pro Glu Arg 
    850                 855                 860                 


Phe Leu Pro Leu Asn Ile Arg Asn Ser Pro Phe Thr Arg Gly Arg Arg 
865                 870                 875                 880 


Glu Asp Tyr Val Gly Gly Gln Ser His Arg Ser Arg Asn Ile Gly Ser 
                885                 890                 895     


Asn Tyr Pro Glu Lys Leu Ser Ala Arg Asp Gly His Asn Gln Lys Asp 
            900                 905                 910         


Asn Thr Lys Ser Lys Glu Lys Glu Ser Glu Asn Ala Pro Gly Asp Gly 
        915                 920                 925             


Lys Gly Asn Lys His Lys Lys His Arg Lys Arg Arg Lys Gly Glu Glu 
    930                 935                 940                 


Ser Glu Gly Phe Leu Asn Pro Glu Leu Leu Glu Thr Ser Arg Lys Ser 
945                 950                 955                 960 


Arg Glu Pro Thr Gly Val Glu Glu Asn Lys Thr Asp Ser Leu Phe Val 
                965                 970                 975     


Leu Pro Ser Arg Asp Asp Ala Thr Pro Val Arg Asp Glu Pro Met Asp 
            980                 985                 990         


Ala Glu Ser Ile Thr Phe Lys Ser  Val Ser Glu Lys Asp  Lys Arg Glu 
        995                 1000                 1005             


Arg Asp  Lys Pro Lys Ala Lys  Gly Asp Lys Thr Lys  Arg Lys Asn 
    1010                 1015                 1020             


Asp Gly  Ser Ala Val Ser Lys  Lys Glu Asn Ile Val  Lys Pro Ala 
    1025                 1030                 1035             


Lys Gly  Pro Gln Glu Lys Val  Asp Gly Glu Arg Glu  Arg Ser Pro 
    1040                 1045                 1050             


Arg Ser  Glu Pro Pro Ile Lys  Lys Ala Lys Glu Glu  Thr Pro Lys 
    1055                 1060                 1065             


Thr Asp  Asn Thr Lys Ser Ser  Ser Ser Ser Gln Lys  Asp Glu Lys 
    1070                 1075                 1080             


Ile Thr  Gly Thr Pro Arg Lys  Ala His Ser Lys Ser  Ala Lys Glu 
    1085                 1090                 1095             


His Gln  Glu Thr Lys Pro Val  Lys Glu Glu Lys Val  Lys Lys Asp 
    1100                 1105                 1110             


Tyr Ser  Lys Asp Val Lys Ser  Glu Lys Leu Thr Thr  Lys Glu Glu 
    1115                 1120                 1125             


Lys Ala  Lys Lys Pro Asn Glu  Lys Asn Lys Pro Leu  Asp Asn Lys 
    1130                 1135                 1140             


Gly Glu  Lys Arg Lys Arg Lys  Thr Glu Glu Lys Gly  Val Asp Lys 
    1145                 1150                 1155             


Asp Phe  Glu Ser Ser Ser Met  Lys Ile Ser Lys Leu  Glu Val Thr 
    1160                 1165                 1170             


Glu Ile  Val Lys Pro Ser Pro  Lys Arg Lys Met Glu  Pro Asp Thr 
    1175                 1180                 1185             


Glu Lys  Met Asp Arg Thr Pro  Glu Lys Asp Lys Ile  Ser Leu Ser 
    1190                 1195                 1200             


Ala Pro  Ala Lys Lys Ile Lys  Leu Asn Arg Glu Thr  Gly Lys Lys 
    1205                 1210                 1215             


Ile Gly  Ser Thr Glu Asn Ile  Ser Asn Thr Lys Glu  Pro Ser Glu 
    1220                 1225                 1230             


Lys Leu  Glu Ser Thr Ser Ser  Lys Val Lys Gln Glu  Lys Val Lys 
    1235                 1240                 1245             


Gly Lys  Val Arg Arg Lys Val  Thr Gly Thr Glu Gly  Ser Ser Ser 
    1250                 1255                 1260             


Thr Leu  Val Asp Tyr Thr Ser  Thr Ser Ser Thr Gly  Gly Ser Pro 
    1265                 1270                 1275             


Val Arg  Lys Ser Glu Glu Lys  Thr Asp Thr Lys Arg  Thr Val Ile 
    1280                 1285                 1290             


Lys Thr  Met Glu Glu Tyr Asn  Asn Asp Asn Thr Ala  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Ile Ile Met Ile Gln  Val Pro Gln Ser Lys  Trp Asp Lys 
    1310                 1315                 1320             


Asp Asp  Phe Glu Ser Glu Glu  Glu Asp Val Lys Ser  Thr Gln Pro 
    1325                 1330                 1335             


Ile Ser  Ser Val Gly Lys Pro  Ala Ser Val Ile Lys  Asn Val Ser 
    1340                 1345                 1350             


Thr Lys  Pro Ser Asn Ile Val  Lys Tyr Pro Glu Lys  Glu Ser Glu 
    1355                 1360                 1365             


Pro Ser  Glu Lys Ile Gln Lys  Phe Thr Lys Asp Val  Ser His Glu 
    1370                 1375                 1380             


Ile Ile  Gln His Glu Val Lys  Ser Ser Lys Asn Ser  Ala Ser Ser 
    1385                 1390                 1395             


Glu Lys  Gly Lys Thr Lys Asp  Arg Asp Tyr Ser Val  Leu Glu Lys 
    1400                 1405                 1410             


Glu Asn  Pro Glu Lys Arg Lys  Asn Ser Thr Gln Pro  Glu Lys Glu 
    1415                 1420                 1425             


Ser Asn  Leu Asp Arg Leu Asn  Glu Gln Gly Asn Phe  Lys Ser Leu 
    1430                 1435                 1440             


Ser Gln  Ser Ser Lys Glu Ala  Arg Thr Ser Asp Lys  His Asp Ser 
    1445                 1450                 1455             


Thr Arg  Ala Ser Ser Asn Lys  Asp Phe Thr Pro Asn  Arg Asp Lys 
    1460                 1465                 1470             


Lys Thr  Asp Tyr Asp Thr Arg  Glu Tyr Ser Ser Ser  Lys Arg Arg 
    1475                 1480                 1485             


Asp Glu  Lys Asn Glu Leu Thr  Arg Arg Lys Asp Ser  Pro Ser Arg 
    1490                 1495                 1500             


Asn Lys  Asp Ser Ala Ser Gly  Gln Lys Asn Lys Pro  Arg Glu Glu 
    1505                 1510                 1515             


Arg Asp  Leu Pro Lys Lys Gly  Thr Gly Asp Ser Lys  Lys Ser Asn 
    1520                 1525                 1530             


Ser Ser  Pro Ser Arg Asp Arg  Lys Pro His Asp His  Lys Ala Thr 
    1535                 1540                 1545             


Tyr Asp  Thr Lys Arg Pro Asn  Glu Glu Thr Lys Ser  Val Asp Lys 
    1550                 1555                 1560             


Asn Pro  Cys Lys Asp Arg Glu  Lys His Val Leu Glu  Ala Arg Asn 
    1565                 1570                 1575             


Asn Lys  Glu Ser Ser Gly Asn  Lys Leu Leu Tyr Ile  Leu Asn Pro 
    1580                 1585                 1590             


Pro Glu  Thr Gln Val Glu Lys  Glu Gln Ile Thr Gly  Gln Ile Asp 
    1595                 1600                 1605             


Lys Ser  Thr Val Lys Pro Lys  Pro Gln Leu Ser His  Ser Ser Arg 
    1610                 1615                 1620             


Leu Ser  Ser Asp Leu Thr Arg  Glu Thr Asp Glu Ala  Ala Phe Glu 
    1625                 1630                 1635             


Pro Asp  Tyr Asn Glu Ser Asp  Ser Glu Ser Asn Val  Ser Val Lys 
    1640                 1645                 1650             


Glu Glu  Glu Ser Ser Gly Asn  Ile Ser Lys Asp Leu  Lys Asp Lys 
    1655                 1660                 1665             


Ile Val  Glu Lys Ala Lys Glu  Ser Leu Asp Thr Ala  Ala Val Val 
    1670                 1675                 1680             


Gln Val  Gly Ile Ser Arg Asn  Gln Ser His Ser Ser  Pro Ser Val 
    1685                 1690                 1695             


Ser Pro  Ser Arg Ser His Ser  Pro Ser Gly Ser Gln  Thr Arg Ser 
    1700                 1705                 1710             


His Ser  Ser Ser Ala Ser Ser  Ala Glu Ser Gln Asp  Ser Lys Lys 
    1715                 1720                 1725             


Lys Lys  Lys Lys Lys Glu Lys  Lys Lys His Lys Lys  His Lys Lys 
    1730                 1735                 1740             


His Lys  Lys His Lys Lys His  Ala Gly Thr Glu Val  Glu Leu Glu 
    1745                 1750                 1755             


Lys Ser  Gln Lys His Lys His  Lys Lys Lys Lys Ser  Lys Lys Asn 
    1760                 1765                 1770             


Lys Asp  Lys Glu Lys Glu Lys  Glu Lys Asp Asp Gln  Lys Val Lys 
    1775                 1780                 1785             


Ser Val  Thr Val 
    1790         


<210>  15
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ala Glu Ala Gly Val Val Gly Ala Gly Ala Ser Pro Asp Gly 
1               5                   10                  15      


Asp Trp Arg Asp Gln Ala Cys Gly Leu Leu Leu His Val His Leu Ser 
            20                  25                  30          


Ser Arg Leu Gly Arg Ala Ala Pro Val Arg Thr Gly Arg His Leu Arg 
        35                  40                  45              


Thr Val Phe Glu Asp Thr Val Glu Glu Arg Val Ile Asn Glu Glu Tyr 
    50                  55                  60                  


Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr Asp Leu Val Met Thr 
65                  70                  75                  80  


His Ala Leu Gln Trp Pro Ser Leu Thr Val Gln Trp Leu Pro Glu Val 
                85                  90                  95      


Thr Lys Pro Glu Gly Lys Asp Tyr Ala Leu His Trp Leu Val Leu Gly 
            100                 105                 110         


Thr His Thr Ser Asp Glu Gln Asn His Leu Val Val Ala Arg Val His 
        115                 120                 125             


Ile Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser His Cys Asp Ser Asp 
    130                 135                 140                 


Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Thr Gly Lys Ile Glu Cys 
145                 150                 155                 160 


Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn Arg Ala Arg Tyr Met 
                165                 170                 175     


Pro Gln Asn Pro His Ile Ile Ala Thr Lys Thr Pro Ser Ser Asp Val 
            180                 185                 190         


Leu Val Phe Asp Tyr Thr Lys His Pro Ala Lys Pro Asp Pro Ser Gly 
        195                 200                 205             


Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His Gln Lys Glu Gly Tyr 
    210                 215                 220                 


Gly Leu Ser Trp Asn Ser Asn Leu Ser Gly His Leu Leu Ser Ala Ser 
225                 230                 235                 240 


Asp Asp His Thr Val Cys Leu Trp Asp Ile Asn Ala Gly Pro Lys Glu 
                245                 250                 255     


Gly Lys Ile Val Asp Ala Lys Ala Ile Phe Thr Gly His Ser Ala Val 
            260                 265                 270         


Val Glu Asp Val Ala Trp His Leu Leu His Glu Ser Leu Phe Gly Ser 
        275                 280                 285             


Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp Thr Arg Ser Asn Thr 
    290                 295                 300                 


Thr Ser Lys Pro Ser His Leu Val Asp Ala His Thr Ala Glu Val Asn 
305                 310                 315                 320 


Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile Leu Ala Thr Gly Ser 
                325                 330                 335     


Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg Asn Leu Lys Leu Lys 
            340                 345                 350         


Leu His Thr Phe Glu Ser His Lys Asp Glu Ile Phe Gln Val His Trp 
        355                 360                 365             


Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser Gly Thr Asp Arg Arg 
    370                 375                 380                 


Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu Glu Gln Ser Ala Glu 
385                 390                 395                 400 


Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe Ile His Gly Gly His 
                405                 410                 415     


Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro Asn Glu Pro Trp Val 
            420                 425                 430         


Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln Ile Trp Gln Met Ala 
        435                 440                 445             


Glu Asn Ile Tyr Asn Asp Glu Glu Ser Asp Val Thr Thr Ser Glu Leu 
    450                 455                 460                 


Glu Gly Gln Gly Ser 
465                 


<210>  16
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr Tyr Asp 
1               5                   10                  15      


Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys Pro 
            20                  25                  30          


His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu Tyr 
        35                  40                  45              


Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala Glu Glu Met 
    50                  55                  60                  


Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg Ser Ile Arg 
65                  70                  75                  80  


Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn Val 
                85                  90                  95      


Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln Leu 
            100                 105                 110         


Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys Leu Asn Lys Gln Gln 
        115                 120                 125             


Thr Asp Ile Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys Lys 
    130                 135                 140                 


Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala Ile 
145                 150                 155                 160 


Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile Asp 
                165                 170                 175     


Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp Arg 
            180                 185                 190         


Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly Thr 
        195                 200                 205             


Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val 
    210                 215                 220                 


Asn Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile 
225                 230                 235                 240 


Phe Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala 
                245                 250                 255     


Val Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly 
            260                 265                 270         


Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val 
        275                 280                 285             


Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr 
    290                 295                 300                 


Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala Leu 
305                 310                 315                 320 


Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu Tyr 
                325                 330                 335     


Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr Asn 
            340                 345                 350         


Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe Glu 
        355                 360                 365             


Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala Ile 
    370                 375                 380                 


Pro Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp Asp 
385                 390                 395                 400 


Pro Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala Cys 
                405                 410                 415     


Glu Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg Lys 
            420                 425                 430         


Asn Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp Glu 
        435                 440                 445             


Lys Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys 
    450                 455                 460                 


Thr Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys 
465                 470                 475                 480 


Leu Ala 
        


<210>  17
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
1               5                   10                  15      


Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
            20                  25                  30          


Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
        35                  40                  45              


Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
    50                  55                  60                  


Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn 
                85                  90                  95      


Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln 
            100                 105                 110         


Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
        115                 120                 125             


Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
    130                 135                 140                 


Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                165                 170                 175     


Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
            180                 185                 190         


Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
        195                 200                 205             


Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
    210                 215                 220                 


Val Asn Phe Pro Met Arg Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
225                 230                 235                 240 


Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                245                 250                 255     


Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
            260                 265                 270         


Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
        275                 280                 285             


Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
    290                 295                 300                 


Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
305                 310                 315                 320 


Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                325                 330                 335     


Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
            340                 345                 350         


Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
    370                 375                 380                 


Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
385                 390                 395                 400 


Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                405                 410                 415     


Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
            420                 425                 430         


Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
        435                 440                 445             


Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
    450                 455                 460                 


Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
465                 470                 475                 480 


Lys Ser Glu Gln Leu Ser Asn Pro 
                485             


<210>  18
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
1               5                   10                  15      


Ser Ser Ser Asn Pro Tyr Leu Ile Arg Arg Ile Glu Glu Leu Asn Lys 
            20                  25                  30          


Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Phe Tyr Arg Arg 
        35                  40                  45              


Arg Asp Ile Ser Ser Thr Leu Ile Ala Leu Ala Asp Lys His Ala Thr 
    50                  55                  60                  


Leu Ser Val Cys Tyr Lys Ala Gly Pro Gly Ala Asp Asn Gly Glu Glu 
65                  70                  75                  80  


Gly Glu Ile Glu Glu Glu Met Glu Asn Pro Glu Met Val Asp Leu Pro 
                85                  90                  95      


Glu Lys Leu Lys His Gln Leu Arg His Arg Glu Leu Phe Leu Ser Arg 
            100                 105                 110         


Gln Leu Glu Ser Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val 
        115                 120                 125             


Thr Leu Leu Asn Glu Thr Glu Ser Leu Lys Ser Tyr Leu Glu Arg Glu 
    130                 135                 140                 


Asp Phe Phe Phe Tyr Ser Leu Val Tyr Asp Pro Gln Gln Lys Thr Leu 
145                 150                 155                 160 


Leu Ala Asp Lys Gly Glu Ile Arg Val Gly Asn Arg Tyr Gln Ala Asp 
                165                 170                 175     


Ile Thr Asp Leu Leu Lys Glu Gly Glu Glu Asp Gly Arg Asp Gln Ser 
            180                 185                 190         


Arg Leu Glu Thr Gln Val Trp Glu Ala His Asn Pro Leu Thr Asp Lys 
        195                 200                 205             


Gln Ile Asp Gln Phe Leu Val Val Ala Arg Ser Val Gly Thr Phe Ala 
    210                 215                 220                 


Arg Ala Leu Asp Cys Ser Ser Ser Val Arg Gln Pro Ser Leu His Met 
225                 230                 235                 240 


Ser Ala Ala Ala Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp 
                245                 250                 255     


Thr Leu His Lys Asn Ile Tyr Asp Ile Ser Lys Ala Ile Ser Ala Leu 
            260                 265                 270         


Val Pro Gln Gly Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp 
        275                 280                 285             


Ser Ala Ser Glu Ala Asn Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly 
    290                 295                 300                 


Lys Asp Phe Thr Asp Ile Gln Gln Asp Phe Leu Pro Trp Lys Ser Leu 
305                 310                 315                 320 


Thr Ser Ile Ile Glu Tyr Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr 
                325                 330                 335     


Val Gln Gln Lys Arg Leu Lys Ala Ala Glu Ala Glu Ser Lys Leu Lys 
            340                 345                 350         


Gln Val Tyr Ile Pro Asn Tyr Asn Lys Pro Asn Pro Asn Gln Ile Ser 
        355                 360                 365             


Val Asn Asn Val Lys Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly 
    370                 375                 380                 


Gln Ser Pro Gly Ala Gly Arg Ala Cys Glu Ser Cys Tyr Met Ser Ser 
385                 390                 395                 400 


Leu Arg Ile Leu Leu Asp Ile Leu Glu Glu Ile Trp Trp Leu Glu Asn 
                405                 410                 415     


Ala Asn Pro Val Arg Trp Arg Glu Ala Arg Thr Lys Pro Gln 
            420                 425                 430 


<210>  19
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Asn Met Tyr Arg Val Gly Asp Tyr Val Tyr Phe Glu Asn 
1               5                   10                  15      


Ser Ser Ser Asn Pro Tyr Leu Val Arg Arg Ile Glu Glu Leu Asn Lys 
            20                  25                  30          


Thr Ala Asn Gly Asn Val Glu Ala Lys Val Val Cys Leu Phe Arg Arg 
        35                  40                  45              


Arg Asp Ile Ser Ser Ser Leu Asn Ser Leu Ala Asp Ser Asn Ala Arg 
    50                  55                  60                  


Glu Phe Glu Glu Glu Ser Lys Gln Pro Gly Val Ser Glu Gln Gln Arg 
65                  70                  75                  80  


His Gln Leu Lys His Arg Glu Leu Phe Leu Ser Arg Gln Phe Glu Ser 
                85                  90                  95      


Leu Pro Ala Thr His Ile Arg Gly Lys Cys Ser Val Thr Leu Leu Asn 
            100                 105                 110         


Glu Thr Asp Ile Leu Ser Gln Tyr Leu Glu Lys Glu Asp Cys Phe Phe 
        115                 120                 125             


Tyr Ser Leu Val Phe Asp Pro Val Gln Lys Thr Leu Leu Ala Asp Gln 
    130                 135                 140                 


Gly Glu Ile Arg Val Gly Cys Lys Tyr Gln Ala Glu Ile Pro Asp Arg 
145                 150                 155                 160 


Leu Val Glu Gly Glu Ser Asp Asn Arg Asn Gln Gln Lys Met Glu Met 
                165                 170                 175     


Lys Val Trp Asp Pro Asp Asn Pro Leu Thr Asp Arg Gln Ile Asp Gln 
            180                 185                 190         


Phe Leu Val Val Ala Arg Ala Val Gly Thr Phe Ala Arg Ala Leu Asp 
        195                 200                 205             


Cys Ser Ser Ser Ile Arg Gln Pro Ser Leu His Met Ser Ala Ala Ala 
    210                 215                 220                 


Ala Ser Arg Asp Ile Thr Leu Phe His Ala Met Asp Thr Leu Gln Arg 
225                 230                 235                 240 


Asn Gly Tyr Asp Leu Ala Lys Ala Met Ser Thr Leu Val Pro Gln Gly 
                245                 250                 255     


Gly Pro Val Leu Cys Arg Asp Glu Met Glu Glu Trp Ser Ala Ser Glu 
            260                 265                 270         


Ala Met Leu Phe Glu Glu Ala Leu Glu Lys Tyr Gly Lys Asp Phe Asn 
        275                 280                 285             


Asp Ile Arg Gln Asp Phe Leu Pro Trp Lys Ser Leu Ala Ser Ile Val 
    290                 295                 300                 


Gln Phe Tyr Tyr Met Trp Lys Thr Thr Asp Arg Tyr Ile Gln Gln Lys 
305                 310                 315                 320 


Arg Leu Lys Ala Ala Glu Ala Asp Ser Lys Leu Lys Gln Val Tyr Ile 
                325                 330                 335     


Pro Thr Tyr Thr Lys Pro Asn Pro Asn Gln Ile Ile Ser Val Gly Ser 
            340                 345                 350         


Lys Pro Gly Met Asn Gly Ala Gly Phe Gln Lys Gly Leu Thr Cys Glu 
        355                 360                 365             


Ser Cys His Thr Thr Gln Ser Ala Gln Trp Tyr Ala Trp Gly Pro Pro 
    370                 375                 380                 


Asn Met Gln Cys Arg Leu Cys Ala Ser Cys Trp Ile Tyr Trp Lys Lys 
385                 390                 395                 400 


Tyr Gly Gly Leu Lys Thr Pro Thr Gln Leu Glu Gly Ala Thr Arg Gly 
                405                 410                 415     


Thr Thr Glu Pro His Ser Arg Gly His Leu Ser Arg Pro Glu Ala Gln 
            420                 425                 430         


Ser Leu Ser Pro Tyr Thr Thr Ser Ala Asn Arg Ala Lys Leu Leu Ala 
        435                 440                 445             


Lys Asn Arg Gln Thr Phe Leu Leu Gln Thr Thr Lys Leu Thr Arg Leu 
    450                 455                 460                 


Ala Arg Arg Met Cys Arg Asp Leu Leu Gln Pro Arg Arg Ala Ala Arg 
465                 470                 475                 480 


Arg Pro Tyr Ala Pro Ile Asn Ala Asn Ala Ile Lys Ala Glu Cys Ser 
                485                 490                 495     


Ile Arg Leu Pro Lys Ala Ala Lys Thr Pro Leu Lys Ile His Pro Leu 
            500                 505                 510         


Val Arg Leu Pro Leu Ala Thr Ile Val Lys Asp Leu Val Ala Gln Ala 
        515                 520                 525             


Pro Leu Lys Pro Lys Thr Pro Arg Gly Thr Lys Thr Pro Ile Asn Arg 
    530                 535                 540                 


Asn Gln Leu Ser Gln Asn Arg Gly Leu Gly Gly Ile Met Val Lys Arg 
545                 550                 555                 560 


Ala Tyr Glu Thr Met Ala Gly Ala Gly Val Pro Phe Ser Ala Asn Gly 
                565                 570                 575     


Arg Pro Leu Ala Ser Gly Ile Arg Ser Ser Ser Gln Pro Ala Ala Lys 
            580                 585                 590         


Arg Gln Lys Leu Asn Pro Ala Asp Ala Pro Asn Pro Val Val Phe Val 
        595                 600                 605             


Ala Thr Lys Asp Thr Arg Ala Leu Arg Lys Ala Leu Thr His Leu Glu 
    610                 615                 620                 


Met Arg Arg Ala Ala Arg Arg Pro Asn Leu Pro Leu Lys Val Lys Pro 
625                 630                 635                 640 


Thr Leu Ile Ala Val Arg Pro Pro Val Pro Leu Pro Ala Pro Ser His 
                645                 650                 655     


Pro Ala Ser Thr Asn Glu Pro Ile Val Leu Glu Asp 
            660                 665             


<210>  20
<211>  19296
<212>  DNA
<213>  Homo sapiens

<400>  20
ccttcagttc ttaaagcgct gcaattcgct gctgcagcca tatttcttac tctctcgggg       60

ctggaagctt cctgactgaa gatctctctg cacttggggt tctttctaga acattttcta      120

gtcccccaac accctttatg gcgtatttct ttaaaaaaat cacctaaatt ccataaaata      180

tttttttaaa ttctatactt tctcctagtg tcttcttgac acgtcctcca tattttttta      240

aagaaagtat ttggaatatt ttgaggcaat ttttaatatt taaggaattt ttctttggaa      300

tcatttttgg ttgacatctc tgttttttgt ggatcagttt tttactcttc cactctcttt      360

tctatatttt gcccatcggg gctgcggata cctggtttta ttattttttc tttgcccaac      420

ggggccgtgg atacctgcct tttaattctt ttttattcgc ccatcggggc cgcggatacc      480

tgctttttat ttttttttcc ttagcccatc ggggtatcgg atacctgctg attcccttcc      540

cctctgaacc cccaacactc tggcccatcg gggtgacgga tatctgcttt ttaaaaattt      600

tctttttttg gcccatcggg gcttcggata cctgcttttt ttttttttat ttttccttgc      660

ccatcggggc ctcggatacc tgctttaatt tttgtttttc tggcccatcg gggccgcgga      720

tacctgcttt gatttttttt tttcatcgcc catcggtgct ttttatggat gaaaaaatgt      780

tggttttgtg ggttgttgca ctctctggaa tatctacact tttttttgct gctgatcatt      840

tggtggtgtg tgagtgtacc taccgctttg gcagagaatg actctgcagt taagctaagg      900

gcgtgttcag attgtggagg aaaagtggcc gccattttag acttgccgca taactcggct      960

tagggctagt cgtttgtgct aagttaaact agggaggcaa gatggatgat agcaggtcag     1020

gcagaggaag tcatgtgcat tgcatgagct aaacctatct gaatgaattg atttggggct     1080

tgttaggagc tttgcgtgat tgttgtatcg ggaggcagta agaatcatct tttatcagta     1140

caagggacta gttaaaaatg gaaggttagg aaagactaag gtgcagggct taaaatggcg     1200

attttgacat tgcggcattg ctcagcatgg cgggctgtgc tttgttaggt tgtccaaaat     1260

ggcggatcca gttctgtcgc agtgttcaag tggcgggaag gccacatcat gatgggcgag     1320

gctttgttaa gtggttagca tggtggtgga catgtgcggt cacacaggaa aagatggcgg     1380

ctgaaggtct tgccgcagtg taaaacatgg cgggcctctt tgtctttgct gtgtgctttt     1440

cgtgttgggt tttgccgcag ggacaatatg gcaggcgttg tcatatgtat atcatggctt     1500

ttgtcacgtg gacatcatgg cgggcttgcc gcattgttaa agatggcggg ttttgccgcc     1560

tagtgccacg cagagcggga gaaaaggtgg gatggacagt gctggattgc tgcataaccc     1620

aaccaattag aaatgggggt ggaattgatc acagccaatt agagcagaag atggaattag     1680

actgatgaca cactgtccag ctactcagcg aagacctggg tgaattagca tggcacttcg     1740

cagctgtctt tagccagtca ggagaaagaa gtggaggggc cacgtgtatg tctcccagtg     1800

ggcggtacac caggtgtttt caaggtcttt tcaaggacat ttagcctttc cacctctgtc     1860

ccctcttatt tgtcccctcc tgtccagtgc tgcctcttgc agtgctggat atctggctgt     1920

gtggtctgaa cctccctcca ttcctctgta ttggtgcctc acctaaggct aagtatacct     1980

ccccccccac cccccaaccc ccccaactcc ccacccccac cccccacccc ccacctcccc     2040

acccccctac ccccctaccc ccctaccccc ctctggtctg ccctgcactg cactgttgcc     2100

atgggcagtg ctccaggcct gcttggtgtg gacatggtgg tgagccgtgg caaggaccag     2160

aatggatcac agatgatcgt tggccaacag gtggcagaag aggaattcct gccttcctca     2220

agaggaacac ctaccccttg gctaatgctg gggtcggatt ttgatttata tttatctttt     2280

ggatgtcagt catacagtct gattttgtgg tttgctagtg tttgaattta agtcttaagt     2340

gactattata gaaatgtatt aagaggcttt atttgtagaa ttcactttaa ttacatttaa     2400

tgagtttttg ttttgagttc cttaaaattc cttaaagttt ttagcttctc attacaaatt     2460

ccttaacctt tttttggcag tagatagtca aagtcaaatc atttctaatg ttttaaaaat     2520

gtgctggtca ttttctttga aattgactta actattttcc tttgaagagt ctgtagcaca     2580

gaaacagtaa aaaatttaac ttcatgacct aatgtaaaaa agagtgtttg aaggtttaca     2640

caggtccagg ccttgctttg ttcccatcct tgatgctgca ctaattgact aatcacctac     2700

ttatcagaca ggaaacttga attgctgtgg tctggtgtcc tctattcaga cttattatat     2760

tggagtattt caatttttcg ttgtatcctg cctgcctagc atccagttcc tccccagccc     2820

tgctcccagc aaacccctag tctagcccca gccctactcc caccccgccc cagccctgcc     2880

ccagccccag tcccctaacc ccccagccct agccccagtc ccagtcctag ttcctcagtc     2940

ccgcccagct tctctcgaaa gtcactctaa ttttcattga ttcagtgctc aaaataagtt     3000

gtccattgct tatcctatta tactgggata ttccgtttac ccttggcatt gctgatcttc     3060

agtactgact ccttgaccat tttcagttaa tgcatacaat cccatttgtc tgtgatctca     3120

ggacaaagaa tttccttact cggtacgttg aagttaggga atgtcaattg agagctttct     3180

atcagagcat tattgcccac aatttgagtt acttatcatt ttctcgatcc cctgccctta     3240

aaggagaaac catttctctg tcattgcttc tgtagtcaca gtcccaattt tgagtagtga     3300

tcttttcttg tgtactgtgt tggccaccta aaactctttg cattgagtaa aattctaatt     3360

gccaataatc ctacccattg gattagacag cactctgaac cccatttgca ttcagcaggg     3420

ggtcgcagac aacccgtctt ttgttggaca gttaaaatgc tcagtcccaa ttgtcatagc     3480

tttgcctatt aaacaaaggc accctactgc gctttttgct gtgcttctgg agaatcctgc     3540

tgttcttgga caattaaaga acaaagtagt aattgctaat tgtctcaccc attaatcatg     3600

aagactacca gtcgcccttg catttgcctt gaggcagcgc tgactacctg agatttaaga     3660

gtttcttaaa ttattgagta aaatcccaat tatccatagt tctgttagtt acactatggc     3720

ctttgcaaac atctttgcat aacagcagtg ggactgactc attcttagag ccccttccct     3780

tggaatatta atggatacaa tagtaattat tcatggttct gcgtaacaga gaagacccac     3840

ttatgtgtat gcctttatca ttgctcctag atagtgtgaa ctacctacca ccttgcatta     3900

atatgtaaaa cactaattgc ccatagtccc actcattagt ctaggatgtc ctctttgcca     3960

ttgctgctga gttctgacta cccaagtttc cttctcttaa acagttgata tgcataattg     4020

catatattca tggttctgtg caataaaaat ggattctcac cccatcccac cttctgtggg     4080

atgttgctaa cgagtgcaga ttattcaata acagctcttg aacagttaat ttgcacagtt     4140

gcaattgtcc agagtcctgt ccattagaaa gggactctgt atcctatttg cacgctacaa     4200

tgtgggctga tcacccaagg actcttcttg tgcattgatg ttcataattg tatttgtcca     4260

cgatcttgtg cactaaccct tccactccct ttgtattcca gcaggggacc cttactactc     4320

aagacctctg tactaggaca gtttatgtgc acaatcctaa ttgattagaa ctgagtcttt     4380

tatatcaagg tccctgcatc atctttgctt tacatcaaga gggtgctggt tacctaatgc     4440

ccctcctcca gaaattattg atgtgcaaaa tgcaatttcc ctatctgctg ttagtctggg     4500

gtctcatccc ctcatattcc ttttgtctta cagcaggggg tacttgggac tgttaatgcg     4560

cataattgca attatggtct tttccattaa attaagatcc caactgctca caccctctta     4620

gcattacagt agagggtgct aatcacaagg acatttcttt tgtactgtta atgtgctact     4680

tgcatttgtc cctcttcctg tgcactaaag accccactca cttccctagt gttcagcagt     4740

ggatgacctc tagtcaagac ctttgcacta ggatagttaa tgtgaaccat ggcaactgat     4800

cacaacaatg tctttcagat cagatccatt ttatcctcct tgttttacag caagggatat     4860

taattaccta tgttaccttt ccctgggact atgaatgtgc aaaattccaa tgttcatggt     4920

ctctcccttt aaacctatat tctacccctt ttacattata gaaagggatg ctggaaaccc     4980

agagtccttc tcttgggact cttaatgtgt atttctaatt atccatgact cttaatgtgc     5040

atattttcaa ttgcctaatt gatttcaatt gtctaagaca tttcaaatgt ctaattgatt     5100

agaactgagt cttttatatc aagctaatat ctagctttta tatcaagcta atatcttgac     5160

ttctcagcat catagaaggg ggtactgatt tcctaaagtc tttcttgaat ttctattatg     5220

caaaattgcc ctgaggccgg gtgtggtggc tcacacctgt aatcccagca ctttgggagg     5280

ctgaggtggg aagatccctt actgccagga gtttgagacc agcctggcca acattaaaaa     5340

aaaaaaaaag taagacaatt gccctggaat cccatccccc tcacacctcc ttggcaaagc     5400

agcaggagtg ctaactagct agtgcttctt ctcttatact gcttaaatgc gcataattag     5460

cagtagttga tgtgccccta tgttagagta gaatcccgct tccttgctcc atttgcatta     5520

ctgcaggagc ttctaactag cctgaattca ctctcttgga ctgttaatgt gcatacttat     5580

atttgctgct gtactttttt accatgtaag gaccccaccc actgtattta catcccagct     5640

ggaagtacct actacttaag acccttagac tagtaaagtt agcgtgcata atcttaggtg     5700

ttatatacac attttcagtt gcatacagtt gtgcctttta tcaggactcc tgtacttatc     5760

aaagcagaga gtgctaatca atattaagcc cttctcttcg aactgtagat ggcatgtaat     5820

tgcagttgtc aatggtcctt caattagact tgggtttctg acctatcaca ccctctttgc     5880

tttattgcat ggggtactat tcacttaagg cccctttctc aaactgttaa tgtgcctaat     5940

gacaattaca tcagtatcct tccttttgaa ggacagcatg gttggtgaca cctaaggccc     6000

catttcttgg cctcccaata tgtgtgattg tatttgtcga ggttgctatg cactagagaa     6060

ggaaagtgct cccctcatcc ccacttttcc cttccagcag gaagtgccca ccccataaga     6120

cccttttatt tggagagtct aggtgcacaa ttgtaagtga ccacaagcat gcatcttgga     6180

catttatgtg cgtaatcgca cactgctcat tccatgtgaa taaggtccta ctctccgacc     6240

ccttttgcaa tacagaaggg ttgctgataa cgcagtcccc ttttcttggc atgttgtgtg     6300

tgattataat cgtctgggat cctatgcact agaaaaggag ggtcctctcc acatacctca     6360

gtctcacctt tcccttccag cagggagtgc ccactccata agactctcac atttggacag     6420

tcaaggtgcg taattgttaa gtgaacacaa ccatgcacct tagacatgga tttgcataac     6480

tacacacagc tcaacctatc tgaataaaat cctactctca gacccctttt gcagtacagc     6540

aggggtgctg atcaccaagg ccctttttcc tggcctggta tgcgtgtgat tatgtttgtc     6600

ccggttcctg tgtattagac atggaagcct cccctgccac actccacccc caatcttcct     6660

ttcccttccg gcagggagtg ccctctccat aagacgctta cgtttggaca atcaaggtgc     6720

acagttgtaa gtgaccacag gcatacacct tggacattaa tgtgcataac cactttgccc     6780

attccatctg aataaggtcc tactctcaga ccccttttgc agtacagcag gggtgctgat     6840

caccaaggcc ccttttcttg gcctgttatg tgcgtgatta tatttgtctg ggttcctgtg     6900

tattagacaa ggaagccttc cccccgcccc cacccccact cccagtcttc ctttcccttc     6960

cagcagggag tgccccctcc ataagatcat tacatttgga caatcaaggt gcacaattat     7020

aagtgaccac agccatgcac cttggacatt attggacatt aatgtgcgta actgcacatg     7080

gcccatccca tctgaataag gtcctactct cagatgccct ttgcagtaca gcaggggtac     7140

tgaatcacca aggccctttt tcttggcctg ttatgtgtgt gattatattt atcccagttt     7200

ctgtgtaata gacatgaaag cctcccctgc cacaccccac ctccaatctt cctttccctt     7260

ccaccaggga gtgtccactc catataccct tacatttgga caatcaaggt gcacaattgt     7320

aagtgagcat aggcactcac cttggacatg aatgtgcata actgcacatg gcccatccca     7380

tctgaataag gtcctactct cagacccttt ttgcagtaca gcaggggtgc tgatcaccaa     7440

ggcccctttt cctggcctgt tatgtgtgtg attatatttg ttccagttcc tgtgtaatag     7500

acatggaagc ctcccctgcc acactccacc cccaatcttc ctttcccttc tggcaggaag     7560

tacccgctcc ataagaccct tacatttgga cagtcaaggt gcacaattgt atgtgaccac     7620

aaccatgcac cttggacata aatgtgtgta actgcacatg gcccatccca tctgaataag     7680

gtcctactct cagacccctt ttgcagtaca gtaggtgtgc tgataaccaa ggcccctctt     7740

cctggcctgt taacgtatgt gattatattt gtctgggttc cagtgtataa gacatggaag     7800

cctcccctgc cccaccccac cctcaatctt cctttccctt ctggcaggga gtgccagctc     7860

cataagaacc ttacatttgg acagtcaagg tgcacaattc taagtgaccg cagccatgca     7920

ccttggtcaa taatgtgtgt aactgcacac ggcctatctc atctgaataa ggccttactc     7980

tcagacccct tttgcagtac agcaggggtg ctgataacca aggcccattt tcctggcctg     8040

ttatgtgtgt gattatattt gtccaggttt ctgtgtacta gacaaggaag cctcctctgc     8100

cccatcccat ctacgcataa tctttctttt cctcccagca gggagtgctc actccataag     8160

acccttacat ttggacaatc aaggtgcaca attgtaagtg accacaacca tgcatcttgg     8220

aaatttatgt gcataactgc acatggctta tcctatttga ataaagtcct actctcagac     8280

cccctttgca gtatagctgg ggtgctgatc actgaggcct ctttgcttgg cttgtctata     8340

ttcttgtgta ctagataagg gcaccttctc atggactccc tttgcttttc aacaaggagt     8400

acccactact ttttaagatt cttatatttg tccaaagtac atggttttaa ttgaccacaa     8460

caatgtccct tggacattaa tgtatgtaat caccacatgg ttcatcctaa ttaaacaaag     8520

ttctaccttc tcaccctcca tttgcagtat accagggttg ctgaccccct aagtcccctt     8580

ttcttggctt gttgacatgc ataattgcat ttatgttggt tcttgtgccc tagacaagga     8640

tgccccacct cttttcaata gtgggtgccc actccttatg atctttacat ttgaacagtt     8700

aatgtgaata attgcagttg tccacaaccc tatcacttct aggaccatta tacctctttt     8760

gcattactgt ggggtatact gtttccctcc aaggcccctt ctggtggact atcaacatat     8820

aattgaaatt ttcttttgtc tttgtcagta gattaaggtc ataccccatc acctttcctt     8880

tgtagtacaa cagggtgtcc tgatcaacca aagtcctgtt gttttggact gttaatatgt     8940

gcaattacat ttgctcctga tctgtgcact agataaggat cctacctact ttcttagtgt     9000

ttttagcagg tagtgcccac tactcaagac tgtcacttgg aatgttcatg tgcacaaact     9060

caattctcta agcatgttcc tgtaccacct ttgctttaga gcagggggat gatattcact     9120

aagtgcccct tcttttggac ttaatatgca ttaatgcaat tgtccacctc ttcttttaga     9180

ctaagagttg atctccacat attccccttg catcaggggc atgttaatta tgaatgaacc     9240

cttttctttt aatattaatg tcataattgt atttgtggac ctgtgtagga gaaaaagacc     9300

ctatgttcct cccattaccc tttggattgc tgctgagaag tgttaactac tcataatctc     9360

agctcttgga caattaatag cattaataac aattatcaag ggcactgatc attagataag     9420

actcctgctt cctcgttgct tacatcgggg gtactgaccc actaaggccc cttgtactgt     9480

taatgtgaat atttgcaatt atatatgtct ccttctggta gagtgggata ttatgcccta     9540

gtatcccctt tgcattactg caggggctgc tgactactca aaacttctcc tgggactgtt     9600

aataggcaca atggcagtta tcaatggttt tctccctccc tgaccttgtt aagcaagcgc     9660

cccaccccac ccttagtttc ccatggcata ataaagtata agcattggag tattccatgc     9720

acttgtctat caaacagtgg tccatactcc caaccctttt gcattgcgcc agtgtgtaaa     9780

atcacaggta gccatggtgt catgctttat atacgaagtc ttccctctct ctgccccttg     9840

tgtgcccttg gccccttttt acagactatt gctcacaatc tcaggtgtcc atatttgcag     9900

ctattaggta agattgtgct gtctccctct tcccttccct ctgccctgcc ccttttgcct     9960

ctttgctggg taatgttgac cagacaaggc cctttctctt ggacttaaac aattctcagt    10020

tgcactttcc ttggtcccac ccattataca tgaacccctc tacttccttt cgcattgctt    10080

ctgagtatgc tgactaccca aagccccttc tgtgttatta ataaacacag tactgattgt    10140

cccatttttc agcccatcag tccaagatct ccctaccact ttggtgtgtt ggtgcagtgt    10200

tgactatgaa aagcaggcct gaactaggtg gataagcctt cactcatttt ctttcattta    10260

ttaatgatcc tagtttcaat tattgtcaga ttctggggac aagaaccatt cttgcccacc    10320

tgtgttactg ctttactgtg caaaatactg aaggcaagtc agacccaggg agctggattg    10380

ccatccttta ttttgtgttt ccagtgtaca ctataaaatt gtctccccag gaaggaaggt    10440

tggcactttc tctgcattct tctttccaga gcagattgcc tggttaagaa tctcttgttg    10500

tcccctttgt atattgttat tgtaaagtgc caaatgccag gatacagcca gaaaaattgc    10560

ttattattat taaaaaaatt tttttaagaa agacatctgg attgtagggt ggactcgata    10620

acctggtcat tatttttttg aagccaaaat atccatttat actatgtacc tggtgaccag    10680

tgtctctcat tttaactgag ggtggtgggt ctgtggatag aacactgact cttgctattt    10740

taatatcaaa gatattctag agtggaactc ttaagaccag tatctttgtg tgggctttac    10800

cagcattcac ttttagaaaa actacctaaa ttttataatc ctttaatttc ttcatctgga    10860

gcacctgccc ctacttattt caagaagatt gcagtaaaac gattaaatga gggaacatat    10920

gcagaggtgc ttttaaaaag catatgccac cttttttatt aattattata taaaatgaag    10980

catttaatta tagtaataat ttgaagtagt ttgaagtacc acactgaggt gaggacttaa    11040

aaatgataag acgagttccc tattttataa gaaaaataag ccaaaattaa atattctttt    11100

ggatataaat ttcaacagtg agatagctgc ctagtggaaa tgaataatat cccagccact    11160

agtgtacagg gtgttttgtg gcacaggatt atgtaatatg gaactgctca agcaaataac    11220

tagtcatcac aacagcagtt ctttgtaata actgaaaaag aatattgttt ctcggagaag    11280

gatgtcaaaa gatcggccca gctcagggag cagtttgccc tactagctcc tcggacagct    11340

gtaaagaaga gtctctggct ctttagaata ctgatcccat tgaagatacc acgctgcatg    11400

tgtccttagt agtcatgtct ccttaggctc ctcttggaca ttctgagcat gtgagacctg    11460

aggactgcaa acagctataa gaggctccaa attaatcata tctttccctt tgagaatctg    11520

gccaagctcc agctaatcta cttggatggg ttgccagcta tctggagaaa aagatcttcc    11580

tcagaagaat aggcttgttg ttttacagtg ttagtgatcc attccctttg acgatcccta    11640

ggtggagatg gggcatgagg atcctccagg ggaaaagctc actaccactg ggcaacaacc    11700

ctaggtcagg aggttctgtc aagatacttt cctggtccca gataggaaga taaagtctca    11760

aaaacaacca ccacacgtca agctcttcat tgttcctatc tgccaaatca ttatacttcc    11820

tacaagcagt gcagagagct gagtcttcag caggtccaag aaatttgaac acactgaagg    11880

aagtcagcct tcccacctga agatcaacat gcctggcact ctagcacttg aggatagctg    11940

aatgaatgtg tatttctttg tctctttctt tcttgtcttt gctctttgtt ctctatctaa    12000

agtgtgtctt acccatttcc atgtttctct tgctaatttc tttcgtgtgt gcctttgcct    12060

cattttctct ttttgttcac aagagtggtc tgtgtcttgt cttagacata tctctcattt    12120

ttcattttgt tgctatttct ctttgctctc ctagatgtgg ctcttctttc acgctttatt    12180

tcatgtctcc tttttgggtc acatgctgtg tgctttttgt ccttttcttg ttctgtctac    12240

ctctcctttc tctgcctacc tctcttttct ctttgtgaac tgtgattatt tgttacccct    12300

tccccttctc gttcgtttta aatttcacct tttttctgag tctggcctcc tttctgctgt    12360

ttctactttt tatctcacat ttctcatttc tgcatttcct ttctgcctct cttgggctat    12420

tctctctctc ctcccctgcg tgcctcagca tctcttgctg tttgtgattt tctatttcag    12480

tattaatctc tgttggcttg tatttgttct ctgcttcttc cctttctact cacctttgag    12540

tatttcagcc tcttcatgaa tctatctccc tctctttgat ttcatgtaat ctctccttaa    12600

atatttcttt gcatatgtgg gcaagtgtac gtgtgtgtgt gtcatgtgtg gcagaggggc    12660

ttcctaaccc ctgcctgata ggtgcagaac gtcggctatc agagcaagca ttgtggagcg    12720

gttccttatg ccaggctgcc atgtgagatg atccaagacc aaaacaaggc cctagactgc    12780

agtaaaaccc agaactcaag tagggcagaa ggtggaaggc tcatatggat agaaggccca    12840

aagtataaga cagatggttt gagacttgag acccgaggac taagatggaa agcccatgtt    12900

ccaagataga tagaagcctc aggcctgaaa ccaacaaaag cctcaagagc caagaaaaca    12960

gagggtggcc tgaattggac cgaaggcctg agttggatgg aagtctcaag gcttgagtta    13020

gaagtcttaa gacctgggac aggacacatg gaaggcctaa gaactgagac ttgtgacaca    13080

aggccaacga cctaagatta gcccagggtt gtagctggaa gacctacaac ccaaggatgg    13140

aaggcccctg tcacaaagcc tacctagatg gatagaggac ccaagcgaaa aaggtatctc    13200

aagactaacg gccggaatct ggaggcccat gacccagaac ccaggaagga tagaagcttg    13260

aagacctggg gaaatcccaa gatgagaacc ctaaacccta cctcttttct attgtttaca    13320

cttcttactc ttagatattt ccagttctcc tgtttatctt taagcctgat tcttttgaga    13380

tgtacttttt gatgttgccg gttaccttta gattgacagt attatgcctg ggccagtctt    13440

gagccagctt taaatcacag cttttaccta tttgttaggc tatagtgttt tgtaaacttc    13500

tgtttctatt cacatcttct ccacttgaga gagacaccaa aatccagtca gtatctaatc    13560

tggcttttgt taacttccct caggagcaga cattcatata ggtgatactg tatttcagtc    13620

ctttcttttg accccagaag ccctagactg agaagataaa atggtcaggt tgttggggaa    13680

aaaaaagtgc caggctctct agagaaaaat gtgaagagat gctccaggcc aatgagaaga    13740

attagacaag aaatacacag atgtgccaga cttctgagaa gcacctgcca gcaacagctt    13800

ccttctttga gcttaggtga gcaggattct ggggtttggg atttctagtg atggttatgg    13860

aaagggtgac tgtgcctggg acaaagcgag gtcccaaggg gacagcctga actccctgct    13920

catagtagtg gccaaataat ttggtggact gtgccaacgc tactcctggg tttaataccc    13980

atctctaggc ttaaagatga gagaacctgg gactgttgag catgtttaat actttccttg    14040

atttttttct tcctgtttat gtgggaagtt gatttaaatg actgataatg tgtatgaaag    14100

cactgtaaaa cataagagaa aaaccaatta gtgtattggc aatcatgcag ttaacatttg    14160

aaagtgcagt gtaaattgtg aagcattatg taaatcaggg gtccacagtt tttctgtaag    14220

gggtcaaatc ataaatactt tagactgtgg gccatatggt ttctgttaca tatttgtttt    14280

ttaaacaacg tttttataag gtcaaaatca ttcttagttt ttgagccaat tggatttggc    14340

ctgctgttca tagcttacca ccccctgatg tattatttgt tattcagaga aaatttctga    14400

atactactag tttccttttc tgtgcctgtc cctgtgctag gcactaaaaa tgcaatgatt    14460

attgatatct aggtgacctg aaaaaaaata gtgaatgtgc tttgtaaact gtaaagcact    14520

tgtattctac tgtgataagc gttgtggata caaagaaagg agcaagcata aaaaagtgct    14580

ctttcaaaag gatatagtac tatgcagaca caaggaattg tttgataaat gaataaatta    14640

tatgtatatt tgaggccaat ttgtgtttgc tgctctggta attttgagta aaaatgcagt    14700

attccaggta tcagaaacga aaacacatgg aaactgcttt taaactttaa aatatactga    14760

aaacataagg gactaagctt gttgtggtca cctataatgt gccagatacc atgctgggtg    14820

ctagagctac caaaggggga aaagtattct catagaacaa aaaatttcag aaaggtgcat    14880

attaaagtgc tttgtaaact aaagcatgat acaaatgtca atgggctaca tatttatgaa    14940

tgaatgaatg gatgaatgaa tattaagtgc ctcttacata ccagctattt tgggtactgt    15000

aaaatacaag attaattctc ctatgtaata agaggaaagt ttatcctcta tactattcag    15060

atgtaaggaa tgatatattg cttaatttta aacaatcaag actttactgg tgaggttaag    15120

ttaaattatt actgatacat ttttccaggt aaccaggaaa gagctagtat gaggaaatga    15180

agtaatagat gtgagatcca gaccgaaagt cacttaattc agcttgcgaa tgtgctttct    15240

aaattataaa gcacttgtaa atgaaaaatt tgatgctttc tgtatgaata aaactttctg    15300

taagctaggt attgtctcta caaaattctc attgtatagt taaaccacag tgagaagggt    15360

tctataagta gttatacaaa ccaagggttt aaatacctgt taaatagatc aattttgatt    15420

gcctactatg tgaactcact gttaaaggca ctgaaaattt atcatatttc atttagccac    15480

agccaaaaat aaggcaatac ctatgttagc attttgtgaa ctctaaggca ccatataaat    15540

gtaactgttg attttctcac ttggtgctgg gtactaggtt tataaaattg tatgatagtt    15600

attatattgt gcaaataaag taggaaaatt tgaataacaa tgattatctt ttgaatacgc    15660

atacgcaagg gattggttgt ctgaagaatg ccactatagt agttatctat tgtgtgccaa    15720

tctcattgct aggcattggg gatgcaaaga taaaccatct ttattgtgtc ttgggtagca    15780

gaagaaaata tgtgtaaaat caatttataa tttgtaaact gccacccata tataagctat    15840

atctgctgaa tgatcattga ttactcttat ccttagagat aacaactggg ggcacaaaca    15900

tttattatca ttattgaacc tacaacagag atctatgtgt agatttacaa agcctacagt    15960

tctatacaga taggaatgaa ctattggctt actgaatggt gattactttc tgtggggctc    16020

ggaactacat gccctaggat ataaaaatga tgttatcatt atagagtgct cacagaagga    16080

aatgaagtaa tataggtgtg agatccagac caaaagtcat ttaacaagtt tattcagtga    16140

tgaaaacatg ggacaaatgg actaatataa ggcagtgtac taagctgagt agagagataa    16200

agtcctgtcc agaagataca tgcttcctgg cctgattgag gagatggaaa atttttgcaa    16260

aaaacaaggt gttgtggtct tccatccagt ttcttaagtg ctgatgataa aagtgaatta    16320

gacccacctt gacctggcct acagaagtaa aggagtaaaa ataaatgcct caggcgtgct    16380

ttttgattca tttgataaac aaagcatctt ttatgtggaa tataccattc tgggtcctga    16440

ggataagaga gatgagggca ttagatcact gacagctgaa gatagaagaa catctttggt    16500

ttgattgttt aaataatatt tcaatgccta ttctctgcaa ggtactatgt ttcgtaaatt    16560

aaataggtct ggcccagaag acccactcaa ttgcctttga gattaaaaaa aaaaaaaaaa    16620

agaaagaaaa atgcaagttt ctttcaaaat aaagagacat ttttcctagt ttcaggaatc    16680

ccccaaatca cttcctcatt ggcttagttt aaagccagga gactgataaa agggctcagg    16740

gtttgttctt taattcatta actaaacatt ctgcttttat tacagttaaa tggttcaaga    16800

tgtaacaact agttttaaag gtatttgctc attggtctgg cttagagaca ggaagacata    16860

tgagcaataa aaaaaagatt cttttgcatt taccaattta gtaaaaattt attaaaactg    16920

aataaagtgc tgttcttaag tgcttgaaag acgtaaacca aagtgcactt tatctcattt    16980

atcttatggt ggaaacacag gaacaaattc tctaagagac tgtgtttctt tagttgagaa    17040

gaaacttcat tgagtagctg tgatatgttc gatactaagg aaaaactaaa cagatcacct    17100

ttgacatgcg ttgtagagtg ggaataagag agggcttttt attttttcgt tcatacgagt    17160

attgatgaag atgatactaa atgctaaatg aaatatatct gctccaaaag gcatttattc    17220

tgacttggag atgcaacaaa aacacaaaaa tggaatgaag tgatactctt catcaaacag    17280

aagtgactgt tatctcaacc attttgttaa atcctaaaca gaaaacaaaa aaaatcatga    17340

cgaaaagaca cttgcttatt aattggcttg gaaagtagaa tataggagaa aggttactgt    17400

ttattttttt tcatgtattc attcattcta caaatatatt cgggtgccaa taggtacttg    17460

gtataaggtt tttggcccca gagacatggg aaaaaaatgc atgccttccc agagaatgcc    17520

taatactttc cttttggctt gttttcttgt taggggcatg gcttagtccc taaataacat    17580

tgtgtggttt aattcctact ccgtatctct tctaccactc tggccactac gataagcagg    17640

tagctgggtt ttgtagtgag cttgctcctt aagttacagg aactctcctt ataatagaca    17700

cttcattttc ctagtccatc cctcatgaaa aatgactgac cactgctggg cagcaggagg    17760

gatgatgacc aactaattcc caaaccccag tctcattggt accagccttg gggaaccacc    17820

tacacttgag ccacaattgg ttttgaagtg catttacaag gtttgtctat tttcagttct    17880

ttacttttta catgctgaca catacataca ctgcctaaat agatctcttt cagaaacaat    17940

cctcagataa cgcatagcaa aatggagatg gagacatgat ttctcatgca acagcttctc    18000

taattatacc ttagaaatgt tctccttttt atcatcaaat ctgctcaaga agggcttttt    18060

atagtagaat aatatcagtg gatgaaaaca gcttaacatt ttaccatgct taagttttaa    18120

gaataaaata aaaattggaa ataattggcc aaaattgaaa ggaaaaattt ttttaaaatt    18180

tctctaaatg taggcctggc tgggctttga ccttttccgt ttttaaatca ctcacagagg    18240

gtgggacagg aggaagagtg aaggaaaagg tcaaacctgt tttaagggca acctgccttt    18300

gttctgaatt ggtcttaaga acattaccag ctccaggttt aaattgttca gtttcatgca    18360

gttccaatag ctgatcattg ttgagatgag gacaaaatcc tttgtcctca ctagtttgct    18420

ttacattttt gaaaagtatt atttttgtcc aagtgcttat caactaaacc ttgtgttagg    18480

taagaatgga atttattaag tgaatcagtg tgacccttct tgtcataaga ttatcttaaa    18540

gctgaagcca aaatatgctt caaaagaaga ggactttatt gttcattgta gttcatacat    18600

tcaaagcatc tgaactgtag tttctatagc aagccaatta catccataag tggagaagga    18660

aatagataaa tgtcaaagta tgattggtgg agggagcaag gttgaagata atctggggtt    18720

gaaattttct agttttcatt ctgtacattt ttagttagac atcagatttg aaatattaat    18780

gtttaccttt caatgtgtgg tatcagctgg actcagtaac acccctttct tcagctgggg    18840

atggggaatg gattattgga aaatggaaag aagaaagtaa ctaaaagcct tcctttcaca    18900

gtttctggca tcactaccac tactgattaa acaagaataa gagaacattt tatcatcatc    18960

tgctttattc acataaatga agttgtgatg aataaatctg cttttatgca gacacaagga    19020

attaagtggc ttcgtcattg tccttctacc tcaaagataa tttattccaa aagctaagat    19080

aaatggaaga ctcttgaact tgtgaactga tgtgaaatgc agaatctctt ttgagtcttt    19140

gctgtttgga agattgaaaa atattgttca gcatgggtga ccaccagaaa gtaatcttaa    19200

gccatctaga tgtcacaatt gaaacaaact ggggagttgg ttgctattgt aaaataaaat    19260

atactgtttt gaaaactttg aaaaaaaaaa aaaaaa                              19296


<210>  21
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
tgtttttttg tttattgggg ttgtg                                             25


<210>  22
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
taaattttaa attaattaaa ttat                                              24


<210>  23
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
tgttttagaa agaattttaa gtgtagaga                                         29


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
agggagcagt ttgccctact                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
cacatgcagc gtggtatctt                                                   20


<210>  26
<211>  8199
<212>  DNA
<213>  Homo sapiens

<400>  26
ttgccctact agctcctcgg acagctgtaa agaagagtct ctggctcttt agaatactgt       60

aagtactact tcgtagctat taagtaatct ttttcctatt ctattttctt tctcttagat      120

gccacctata gaaaagtcag agggtccagt aagtttcttt ccttcttccc acctcatctg      180

caatatatat atatagagag agaaatagat acatacatac atgcataaat acacatatgt      240

gagttaacca gcagaactgt agaattaata ttgtggaccc agctctatgc taggttacac      300

tgataacctg ggtaggaatg atatcatcct atataatttc attcctgaga tgattttatc      360

gttgaggagc taatgtgagc acatttgaaa taactttaga aaataataag tgctgttttg      420

tgtgaatcat aagtagtagt tttaggaagg gaacccacaa ggatttgaag ttgatagaat      480

aaacttaagg aagtgggttt gctttttctc tttaagccaa gataggatta atattgcagc      540

catctggata gtccagttgg tttattttaa tttcatttgt tttttacctc ttttggagcc      600

atggaaagag atgaaaggga tagagcatag ccattgtgtt tggctatttg cgaaggttgg      660

caaattagtg attgctaaat ctcataagct tgagtatttt aaagttcaga gattgagggc      720

ataaatctaa tacttcggct ccttccacaa ttttactaca tttctgccca agaacagatg      780

accatggata atgcatatcg tagatacttt ttaagtttgg aacctttttg ccaagagggt      840

agtggagaag tgaagtcaaa accttgacct tccttgccta ctttatgctg tagtttatat      900

accttctttc ctcccacctt tcgtaaagct aaaagaagct tagcctcctt aatgttttcc      960

agctgacaaa atattgttta acataacatt cgaaactttt tttctggtgc acattcatgc     1020

atcacagcag gagcaacaag aaccatataa gtgaactggc ttcacttata gcccgtttta     1080

attcatatcc atatttcctc agggcttgtt tccatgcctc ccagccccac tccatatgct     1140

taacaacatt gtctggctga ctgagggtta tatacatcat ggtcttgaac cttcttggaa     1200

acatggtctg tgccattgtt tctcaaaccc aagtaatgct tcatgatgaa acaccttcta     1260

aaggaacaaa attttctgag atcctaaaaa aatgtgtttt gaggaacact gacttaacaa     1320

agatatttga aatgtaaata tgttttccaa tttcacgttg tctttgtcaa agatgtgttt     1380

tatataactt atgtagaact tggggatcca ttagaatata ttcacaaatc cccagggtta     1440

tcaccccaat ttgagaaacc ctggtctatg cttatgaaat cttctattgg taattaaatt     1500

gtcattcatt gtcaacatac aattataatt attattggaa tttgttttaa atgaatgaat     1560

ttggaggtga ttctgtacct taagtcaaga ggaaggatgg cttgatttta ggtggattga     1620

ttatactaga tagcatccaa aggtgaatct tgaagctgta tttaaattca ttgcttgaaa     1680

taatttccac ccttaagaaa aatctctagc aattgtaaaa agggatgctc tggaaatgtg     1740

ggcatcttca aaatagagat aattcttgtg ttagttcaac aaatattatt gtaccaggtg     1800

ctggaataaa tagcaaaacc aaagacagga tttatatcaa ggaatttgct ttcttatgga     1860

ggatgcagaa ggaaatcatt atggttttgg gcagaaatgc ttagacttta gtcctggctc     1920

tgagtttggt tcagatcacc atcaatctga ccatctcgag actgctagtg aaataagata     1980

ggggcttata tcaaatacct aaatccctga aaatgacatt ttgtgatttg gaaaattttc     2040

aaaagtctaa tgaaggaaac ttttttggca tttctttaaa tgattattgt catttctttt     2100

ctgacttttc cctttataaa accttaacat gtaggattgg aggaagtttt ctgaccattt     2160

tctcatatcc tctttcagct ttatctttct gtaacttcca tttctctagc cacctcccta     2220

aattacagaa gactgtgaga cccagggctg ctgtgattag gcattcataa tttcttttca     2280

gggtgtttgt gccctgatta tcaaatgtac agcttgaagg gagttcatgt cttaaagtaa     2340

tgaattaaga gttgaccttt gttgactgct aaaatattct tatatgtgaa agcatcctgg     2400

aaaaatacgt taccagctta aagagaaaga aactaatgat tatatctgaa ctgagctaat     2460

gcctcttctc ttcccccaaa ccttatcagt ttggatggca aagagtaatg atgtgtcagt     2520

taaacagagc taatgccttc ctctgccttg tcttaaagac tggattggga gaaaattgat     2580

attctcacta ccatattttg ggctgtaggc aagtagcatt ttacacaggt ttccttcaaa     2640

aatccaactc aagttggagc tcatgtattt aagacatagc tggcctgctg aatttaacaa     2700

gttaaacttc agtggccatg tacagttata tatcactata tatatgtgta ttaggctgtc     2760

gagttggtca tgtttttgtt ggtgacttag gctttacttg atagctcttc cttgaccttt     2820

ccaaattgag tactgataca tggagcttgg gcttcttctg catcttatac aaatgagttt     2880

ggtaaagaag cctctccttt actgttttga tgtttatatt agaaataact tttgattatt     2940

ttttttcatg ttaggatgag aaactgaaac aaaatgtaaa tttgaccggt gctagacttc     3000

ttaaattatg ggtagactta aagtattatt ttccttaacc aattagaatg ctagtcttct     3060

agtgttcccg gaaacatgag aggttatgca gtagacccaa gcaataccct cttattacat     3120

aatcaagtgc gtataagaat ttaaaaatag ggatatgact ggaacatcac tgtactttac     3180

caggtcccat tataaaatta tctatgttac tttacccata gctttgaaaa ctagtggcat     3240

agtatatttt atagtatgct gttagtgtga ttggcattga acagtgatgg gatataatca     3300

ctctacaatc tatatgttat taaagttttc cagccttata gatctccctt gactgaaaat     3360

tagctactaa cttacgactt attttttaca gcagattgac taggtctttc caggaaatct     3420

gttgatgtac aaaaacaaag tttaattgct aatgtttttt taaaaaataa ctttttgata     3480

ttacggatac ctggttattt gggccttgta tattttaaca tcaaaattac ctattataaa     3540

tccatataaa cagaaaagaa agagagtaag tctttagatc agatctgcaa acaatgatgg     3600

tacgtactgt agaaaaatct ggaacataga cttaccagtt cttaggttcc attttgcttg     3660

ctttttaaaa actgtgtctt ataagtcttc agcaactggt tgggagattt ttagaaaaaa     3720

taacctttta atgttagaac agtgtagaga tttacagaat gattctgaag atagagtttc     3780

tgtgtacttc acacccagtt tttcccagtg ttaacatttt acattagttt ggtacatttg     3840

tcacaacaaa ccaatattga tacattatta ttaactagag tccatatttt attcagattt     3900

ccttagtttt tccttaatgt tctttttgtg ttccaggatc ccattgaaga taccacgctg     3960

catgtgtcct tagtagtcat gtctccttag gctcctcttg gtaatgacag tttctcagac     4020

tctttgtttt tgatgaactt cacagttttg aggactaatg gtccagtatt ctatagaatg     4080

tctctctatt ggaatttgtc tgatgttctt ctcatgacta gattgggttt atgagtgttt     4140

aggaggaaga ccacaaaggt agagtgccat tcttatcact tatcaagagt acatactatc     4200

aacatgactt atcactgttt atgttatcct taatcacctg tctgaggtac tatttgtcag     4260

gtttctccag cgtaaaatta gtctttattt ctccatttcc ctactatact gttcacatag     4320

gaagtcacta tgtgcagcca gcacttaagg aatgggaaat taccttccac ctcattgagg     4380

gcagagtatt tacataaatt atttggaatt cttttgcaca ggatgtcttt tctccacaat     4440

gtattgtgtt tattcagtca tttatatcag tatgatctca gggatatttt atactctggg     4500

ttataataca gtattacttt attctgttgt tcaaattgtt ccagctttgg ccattgggag     4560

gtctttcatt tggctttgat ataaccccat gaatgtgggt tttttgtttg agcactttct     4620

tatttttgga actacaacat gcttcagact catttgcata tctcctgcct ggacctaaaa     4680

tgatgtattt ctgcaaggag ccttgatact ttttattgga gagtaatatt agaaatcaag     4740

aagtgaatgc taggtgcgct cattactact ggagtgtcat tccttcaaga ccttttcagt     4800

tgacaagagc aaggagatat atatttgcat tctaacgtgt gtatatgcac atagctataa     4860

atatatataa ccatctgtat ctatattaaa ctaaatgtgt ttatacctac gtctccaact     4920

ctaatcattg ccacatggat cattatagtc tcacctcctt gcttatctgt tacctcccat     4980

ttctacagtg agaaacctgg cttggttggg aaatttttct gttaatatta cggtagtgag     5040

tgtttgacat ttgcttctat ggttaagttt agggagagtt tagctgtagg gtattcttga     5100

aactagaaat gacccttctg ccctaaatgt ttctgccagt tttgaaacgt aaaataggtt     5160

gcagaaacaa actttatctt aagaaccaga atttacttca atccacattt tgacattgat     5220

tttcagatta aattattctg atatcgccag gtaagctgtt ccttgggtat gcatttcttc     5280

tttccgtttt tttctaagag ctaaaggacc ctgagaacac tggaggtggg aaaggaaggg     5340

aaaggcatgt tcacacgtgg gataggaaag gttcatttac tgacctccag ctagccttcc     5400

aaagtgccta tttaagaccc aaggagtaga tgtcttcctt ggcaattgta acccaaatat     5460

aatttttaac ctttcaattt tagtcaagaa agttggtgtg ctgttacaaa aagtgccctg     5520

attaacagca ttgtcatgtg cattgcatat taatcagcaa tttaaaataa catgaaatta     5580

tgttgagtat aattttaata ttttatatta gatattagtt tgagacagtg tttctcaagt     5640

ctgtataata agtttgatag tagggaggtt ttctctcaag aaaagaatta ttcagtgtgc     5700

acctacataa tcactgctta gattctacaa ttaatatttt gctatatttg attaaacgtt     5760

ttctgtaaaa gaaaaatatt attatgtact atttaggttt atgggaataa ttgttaagtt     5820

aaagtgtatg aacaaacctg gaatgaaatc tgtttgccta catctataat acaactataa     5880

aacatagcag atgtacaaat tagtagttaa tagataacta aaatgcaaat atggcactac     5940

tattatagta ttatagtttc ttttgagtgg cgtgtctgta atatcacatg ctgtgttgat     6000

gcacttcacc aaactgctgt tttcaaactg ctttaaatcc tgccattata gcacatagca     6060

atgctatttc actttcattt ggcacaaaac acatttatat attgtttgct tctcttcttt     6120

tctgtaatcc ccaggcaaca aaactagaac atttgccact aatctggcaa cgtggtccta     6180

tattatgaag tagtcatata gctgatctaa actatcctta cagtgaaatg agagtattgt     6240

gaaagttttg tagaaagctc cccatatgtc ctgagaatct atgcacagac cccacagtta     6300

aaagaccttt gaattgtggg aagacatggg tttaagtatc acttggttac cttctatttg     6360

tgtaacattg aggtagtttc atcttctggg ttcccagttt ccttagagaa tgaaaatgtt     6420

gaattatgtg attttttttt ttttttgaga cggagttttg ctctttcgcc caggctggag     6480

tgaagtagca cgatctcgac tcactgcaac ctccttcccc catgatcaag caattctcct     6540

gcctcagcct cccaagtagc tgggattaca ggcacccgcc ccccaccccc cgcccccagc     6600

taatgtttgt atttttagta cagatggagt tttgccgtgt tggccaggct ggtctcgaac     6660

ttctgacctc aggtgatcca ctcgccttgg cctcccaaag tgctaggatt acaggcatga     6720

gccactgcgc ctggcctatg tgattattaa tatcacgtct agctgtgaca attctgtctg     6780

atgctggagt atttgaacca gatggctggc tgtgccactc agttattctc tccataagac     6840

tttgatattt tgttggtctg caagatgacg gattctcaaa attcttgtca gtgaatattg     6900

aaccctagtg aaatgtatgg ttctgtatca gttccaaaat gtaaccactt tctctagcct     6960

tagattccca gttccaaaat gtaaccattt tctctagcct tagattcccg ttaagggaaa     7020

gggaatgctc tttgagtatg tcatcaccat agtaacaggc aaaactagag ggctttgatg     7080

ctaaagcaag atactccata aatatgctta agaagacttg gggagactgg aatagttgtt     7140

cccttttaga tgccagtgta taaatgaatt tgagctagga tccgtttatt taaaatttct     7200

ttaggtgtat ttgcttgcat atggagtgca catttactct cattaatgga gttttaggaa     7260

gcagtagagt aaatgcataa acatgtatga accgccatgt ttaactggaa gcctgcattt     7320

ggaagtcaag tatctaatct tagattaaat taggatgggg aaggatgttg gcaagagatt     7380

ttgaagcttg ttctgcttat attgagaaca tcatagaaca gtttggcctt tttaaagcta     7440

gagaatagtg ttgaataagt gatgttccat atattcctgt ttgacattga cataaaggtt     7500

tcctcatgat acagtaatcc ctgatcaggg atctggaagc ctgtattcat ttaaggtact     7560

caggtttaac atactgggtg cttttcacac catactatac agtaccatgc aaagtgcttt     7620

caagactgca aatttggctt agatcccctt tagtgagctc ctatgctata gtaaaggtag     7680

atagccaatt attaaaaaca gtcaagacaa ttgcacctct aagcagtagt agcagttgcc     7740

acaccacctt gaatcttgaa gtattttcag caacaggatg accattagcc acaaatttag     7800

tgtcagccct taaggtcggt attggtttga cccatatttt catgtagttc tttttcttca     7860

cttgtctaat cttcccgtgt actgccaggg cttgtcatta gaggacttta gggagaccaa     7920

gcaggctaga aagtagagac aggagatacc tatgtctaat gcttcagttt atacttccta     7980

ggtttttttc attggggttt ttgtaactct tttggtatcc taccggtgct ttggtagcct     8040

actgaaccct gtctttcttc ttaaggacat tctgagcatg tgagacctga ggactgcaaa     8100

cagctataag aggctccaaa ttaatcatat ctttcccttt gagaatctgg ccaagctcca     8160

gctaatctac ttggatgggt tgccagctat ctggagaaa                            8199


<210>  27
<211>  3578
<212>  DNA
<213>  Homo sapiens

<400>  27
aatttcacct tttttctgag tctggcctcc tttctgctgt ttctactttt tatctcacat       60

ttctcatttc tgcatttcct ttctgcctct cttgggctat tctctctctc ctcccctgcg      120

tgcctcagca tctcttgctg tttgtgattt tctatttcag tattaatctc tgttggcttg      180

tatttgttct ctgcttcttc cctttctact cacctttgag tatttcagcc tcttcatgaa      240

tctatctccc tctctttgat ttcatgtaat ctctccttaa atatttcttt gcatatgtgg      300

gcaagtgtac gtgtgtgtgt gtcatgtgtg gcagaggggc ttcctaaccc ctgcctgata      360

ggtgcagaac gtcggctatc agagcaagca ttgtggagcg gttccttatg ccaggctgcc      420

atgtgagatg atccaagacc aaaacaaggc cctagactgc agtaaaaccc agaactcaag      480

tagggcagaa ggtggaaggc tcatatggat agaaggccca aagtataaga cagatggttt      540

gagacttgag acccgaggac taagatggaa agcccatgtt ccaagataga tagaagcctc      600

aggcctgaaa ccaacaaaag cctcaagagc caagaaaaca gagggtggcc tgaattggac      660

cgaaggcctg agttggatgg aagtctcaag gcttgagtta gaagtcttaa gacctgggac      720

aggacacatg gaaggcctaa gaactgagac ttgtgacaca aggccaacga cctaagatta      780

gcccagggtt gtagctggaa gacctacaac ccaaggatgg aaggcccctg tcacaaagcc      840

tacctagatg gatagaggac ccaagcgaaa aaggtatctc aagactaacg gccggaatct      900

ggaggcccat gacccagaac ccaggaagga tagaagcttg aagacctggg gaaatcccaa      960

gatgagaacc ctaaacccta cctcttttct attgtttaca cttcttactc ttagatattt     1020

ccagttctcc tgtttatctt taagcctgat tcttttgaga tgtacttttt gatgttgccg     1080

gttaccttta gattgacagt attatgcctg ggccagtctt gagccagctt taaatcacag     1140

cttttaccta tttgttaggc tatagtgttt tgtaaacttc tgtttctatt cacatcttct     1200

ccacttgaga gagacaccaa aatccagtca gtatctaatc tggcttttgt taacttccct     1260

caggagcaga cattcatata ggtgatactg tatttcagtc ctttcttttg accccagaag     1320

ccctagactg agaagataaa atggtcaggt tgttggggaa aaaaaagtgc caggctctct     1380

agagaaaaat gtgaagagat gctccaggcc aatgagaaga attagacaag aaatacacag     1440

atgtgccaga cttctgagaa gcacctgcca gcaacagctt ccttctttga gcttaggtga     1500

gcaggattct ggggtttggg atttctagtg atggttatgg aaagggtgac tgtgcctggg     1560

acaaagcgag gtcccaaggg gacagcctga actccctgct catagtagtg gccaaataat     1620

ttggtggact gtgccaacgc tactcctggg tttaataccc atctctaggc ttaaagatga     1680

gagaacctgg gactgttgag catgtgtaat actttccttg atttttttct tcctgtttat     1740

gtgggaagtt gatttaaatg actgataatg tgtatgaaag cactgtaaaa cataagagaa     1800

aaaccaatta gtgtattggc aatcatgcag ttaacatttg aaagtgcagt gtaaattgtg     1860

aagcattatg taaatcaggg gtccacagtt tttctgtaag gggtcaaatc ataaatactt     1920

tagactgtgg gccatatggt ttctgttaca tatttgtttt ttaaacaacg tttttataag     1980

gtcaaaatca ttcttagttt ttgagccaat tggatttggc ctgctgttca tagcttacca     2040

ccccctgatg tattatttgt tattcagaga aaatttctga atactactag tttccttttc     2100

tgtgcctgtc cctgtgctag gcactaaaaa tgcaatgatt attgatatct aggtgacctg     2160

aaaaaaaata gtgaatgtgc tttgtaaact gtaaagcact tgtattctac tgtgataagc     2220

gttgtggata caaagaaagg agcaagcata aaaaagtgct ctttcaaaag gatatagtac     2280

tatgcagaca caaggaattg tttgataaat gaataaatta tatgtatatt tgaggccaat     2340

ttgtgtttgc tgctctggta attttgagta aaaatgcagt attccaggta tcagaaacga     2400

aaacacatgg aaactgcttt taaactttaa aatatactga aaacataagg gactaagctt     2460

gttgtggtca cctataatgt gccagatacc atgctgggtg ctagagctac caaaggggga     2520

aaagtattct catagaacaa aaaatttcag aaaggtgcat attaaagtgc tttgtaaact     2580

aaagcatgat acaaatgtca atgggctaca tatttatgaa tgaatgaatg gatgaatgaa     2640

tattaagtgc ctcttacata ccagctattt tgggtactgt aaaatacaag attaattctc     2700

ctatgtaata agaggaaagt ttatcctcta tactattcag atgtaaggaa tgatatattg     2760

cttaatttta aacaatcaag actttactgg tgaggttaag ttaaattatt actgatacat     2820

ttttccaggt aaccaggaaa gagctagtat gaggaaatga agtaatagat gtgagatcca     2880

gaccgaaagt cacttaattc agcttgcgaa tgtgctttct aaattataaa gcacttgtaa     2940

atgaaaaatt tgatgctttc tgtatgaata aaactttctg taagctaggt attgtctcta     3000

caaaattctc attgtatagt taaaccacag tgagaagggt tctataagta gttatacaaa     3060

ccaagggttt aaatacctgt taaatagatc aattttgatt gcctactatg tgaactcact     3120

gttaaaggca ctgaaaattt atcatatttc atttagccac agccaaaaat aaggcaatac     3180

ctatgttagc attttgtgaa ctctaaggca ccatataaat gtaactgttg attttctcac     3240

ttggtgctgg gtactaggtt tataaaattg tatgatagtt attatattgt gcaaataaag     3300

taggaaaatt tgaataacaa tgattatctt ttgaatacgc atacgcaagg gattggttgt     3360

ctgaagaatg ccactatagt agttatctat tgtgtgccaa tctcattgct aggcattggg     3420

gatgcaaaga taaaccatct ttattgtgtc ttgggtagca gaagaaaata tgtgtaaaat     3480

caatttataa tttgtaaact gccacccata tataagctat atctgctgaa tgatcattga     3540

ttactcttat ccttagagat aacaactggg ggcacaaa                             3578


<210>  28
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  29
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  30
<211>  3808
<212>  DNA
<213>  Homo sapiens

<400>  30
cttcctggac tggggatccc ggctaaatat agctgtttct gtcttacaac acaggctcca       60

gtatataaat caggcaaatt ccccatttga gcatgaacct ctgaaaactg ccggcatctg      120

aggtttcctc caaggccctc tgaagtgcag cccataatga aggtcttggc ggcagtacac      180

agcccagggg gagccgttcc ccaacaacct ggacaagcta tgtggcccca acgtgacgga      240

cttcccgccc ttccacgcca acggcacgga gaaggccaag ctggtggagc tgtaccgcat      300

agtcgtgtac cttggcacct ccctgggcaa catcacccgg gaccagaaga tcctcaaccc      360

cagtgccctc agcctccaca gcaagctcaa cgccaccgcc gacatcctgc gaggcctcct      420

tagcaacgtg ctgtgccgcc tgtgcagcaa gtaccacgtg ggccatgtgg acgtgaccta      480

cggccctgac acctcgggta aggatgtctt ccagaagaag aagctgggct gtcaactcct      540

ggggaagtat aagcagatca tcgccgtgtt ggcccaggcc ttctagcagg aggtcttgaa      600

gtgtgctgtg aaccgaggga tctcaggagt tgggtccaga tgtgggggcc tgtccaaggg      660

tggctggggc ccagggcatc gctaaaccca aatgggggct gctggcagac cccgagggtg      720

cctggccagt ccactccact ctgggctggg ctgtgatgaa gctgagcaga gtggaaactt      780

ccatagggag ggagctagaa gaaggtgccc cttcctctgg gagattgtgg actggggagc      840

gtgggctgga cttctgcctc tacttgtccc tttggcccct tgctcacttt gtgcagtgaa      900

caaactacac aagtcatcta caagagccct gaccacaggg tgagacagca gggcccaggg      960

gagtggacca gcccccagca aattatcacc atctgtgcct ttgctgcccc ttaggttggg     1020

acttaggtgg gccagagggg ctaggatccc aaaggactcc ttgtccccta gaagtttgat     1080

gagtggaaga tagagagggg cctctgggat ggaaggctgt cttcttttga ggatgatcag     1140

agaacttggg cataggaaca atctggcaga agtttccaga aggaggtcac ttggcattca     1200

ggctcttggg gaggcagaga agccaccttc aggcctggga aggaagacac tgggaggagg     1260

agaggcctgg aaagctttgg taggttcttc gttctcttcc ccgtgatctt ccctgcagcc     1320

tgggatggcc agggtctgat ggctggacct gcagcagggg tttgtggagg tgggtagggc     1380

aggggcaggt tgctaagtca ggtgcagagg ttctgaggga cccaggctct tcctctgggt     1440

aaaggtctgt aagaaggggc tggggtagct cagagtagca gctcacatct gaggccctgg     1500

gaggccttgt gaggtcacac agaggtactt gagggggact ggaggccgtc tctggtcccc     1560

agggcaaggg aacagcagaa cttagggtca gggtctcagg gaaccctgag ctccaagcgt     1620

gctgtgcgtc tgacctggca tgatttctat ttattatgat atcctattta tattaactta     1680

ttggtgcttt cagtggccaa gttaattccc ctttccctgg tccctactca acaaaatatg     1740

atgatggctc ccgacacaag cgccagggcc agggcttagc agggcctggt ctggaagtcg     1800

acaatgttac aagtggaata agccttacgg gtgaagctca gagaagggtc ggatctgaga     1860

gaatggggag gcctgagtgg gagtgggggg ccttgctcca ccccccccca tcccctactg     1920

tgacttgctt tagggtgtca gggtccaggc tgcaggggct gggccaattt gtggagaggc     1980

cgggtgcctt tctgtcttga ttccaggggg ctggttcaca ctgttcttgg gcgccccagc     2040

attgtgttgt gaggcgcact gttcctggca gatattgtgc cccctggagc agtgggcaag     2100

acagtccttg tggcccaccc tgtccttgtt tctgtgtccc catgctgcct ctgaaatagc     2160

gccctggaac aaccctgccc ctgcacccag catgctccga cacagcaggg aagctcctcc     2220

tgtggcccgg acacccatag acggtgcggg gggcctggct gggccagacc ccaggaaggt     2280

ggggtagact ggggggatca gctgcccatt gctcccaaga ggaggagagg gaggctgcag     2340

atgcctggga ctcagaccag gaagctgtgg gccctcctgc tccaccccca tcccactccc     2400

acccatgtct gggctcccag gcagggaacc cgatctcttc ctttgtgctg gggccaggcg     2460

agtggagaaa cgccctccag tctgagagca ggggagggaa ggaggcagca gagttggggc     2520

agctgctcag agcagtgttc tggcttcttc tcaaaccctg agcgggctgc cggcctccaa     2580

gttcctccga caagatgatg gtactaatta tggtactttt cactcacttt gcacctttcc     2640

ctgtcgctct ctaagcactt tacctggatg gcgcgtgggc agtgtgcagg caggtcctga     2700

ggcctggggt tggggtggag ggtgcggccc ggagttgtcc atctgtccat cccaacagca     2760

agacgaggat gtggctgttg agatgtgggc cacactcacc cttgtccagg atgcagggac     2820

tgccttctcc ttcctgcttc atccggctta gcttggggct ggctgcattc ccccaggatg     2880

ggcttcgaga aagacaaact tgtctggaaa ccagagttgc tgattccacc cggggggccc     2940

ggctgactcg cccatcacct catctccctg tggacttggg agctctgtgc caggcccacc     3000

ttgcggccct ggctctgagt cgctctccca cccagcctgg acttggcccc atgggaccca     3060

tcctcagtgc tccctccaga tcccgtccgg cagcttggcg tccaccctgc acagcatcac     3120

tgaatcacag agcctttgcg tgaaacagct ctgccaggcc gggagctggg tttctcttcc     3180

ctttttatct gctggtgtgg accacacctg ggcctggccg gaggaagaga gagtttacca     3240

agagagatgt ctccgggccc ttatttatta tttaaacatt tttttaaaaa gcactgctag     3300

tttacttgtc tctcctcccc atcgtcccca tcgtcctcct tgtccctgac ttggggcact     3360

tccaccctga cccagccagt ccagctctgc cttgccggct ctccagagta gacatagtgt     3420

gtggggttgg agctctggca cccggggagg tagcatttcc ctgcagatgg tacagatgtt     3480

cctgccttag agtcatctct agttccccac ctcaatcccg gcatccagcc ttcagtcccg     3540

cccacgtgct agctccgtgg gcccaccgtg cggccttaga ggtttccctc cttcctttcc     3600

actgaaaagc acatggcctt gggtgacaaa ttcctctttg atgaatgtac cctgtgggga     3660

tgtttcatac tgacagatta tttttattta ttcaatgtca tatttaaaat atttattttt     3720

tataccaaat gaatactttt ttttttaaga aaaaaaagag aaatgaataa agaatctact     3780

cttggctggc aaaaaaaaaa aaaaaaaa                                        3808


<210>  31
<211>  2217
<212>  DNA
<213>  Homo sapiens

<400>  31
ccccgccgcc gccgcccttc gcgccctggg ccatctccct cccacctccc tccgcggagc       60

agccagacag cgagggcccc ggccgggggc aggggggacg ccccgtccgg ggcacccccc      120

cggctctgag ccgcccgcgg ggccggcctc ggcccggagc ggaggaagga gtcgccgagg      180

agcagcctga ggccccagag tctgagacga gccgccgccg cccccgccac tgcggggagg      240

agggggagga ggagcgggag gagggacgag ctggtcggga gaagaggaaa aaaacttttg      300

agacttttcc gttgccgctg ggagccggag gcgcggggac ctcttggcgc gacgctgccc      360

cgcgaggagg caggacttgg ggaccccaga ccgcctccct ttgccgccgg ggacgcttgc      420

tccctccctg ccccctacac ggcgtccctc aggcgccccc attccggacc agccctcggg      480

agtcgccgac ccggcctccc gcaaagactt ttccccagac ctcgggcgca ccccctgcac      540

gccgccttca tccccggcct gtctcctgag cccccgcgca tcctagaccc tttctcctcc      600

aggagacgga tctctctccg acctgccaca gatcccctat tcaagaccac ccaccttctg      660

gtaccagatc gcgcccatct aggttatttc cgtgggatac tgagacaccc ccggtccaag      720

cctcccctcc accactgcgc ccttctccct gaggacctca gctttccctc gaggccctcc      780

taccttttgc cgggagaccc ccagcccctg caggggcggg gcctccccac cacaccagcc      840

ctgttcgcgc tctcggcagt gccggggggc gccgcctccc ccatgccgcc ctccgggctg      900

cggctgctgc cgctgctgct accgctgctg tggctactgg tgctgacgcc tggccggccg      960

gccgcgggac tatccacctg caagactatc gacatggagc tggtgaagcg gaagcgcatc     1020

gaggccatcc gcggccagat cctgtccaag ctgcggctcg ccagcccccc gagccagggg     1080

gaggtgccgc ccggcccgct gcccgaggcc gtgctcgccc tgtacaacag cacccgcgac     1140

cgggtggccg gggagagtgc agaaccggag cccgagcctg aggccgacta ctacgccaag     1200

gaggtcaccc gcgtgctaat ggtggaaacc cacaacgaaa tctatgacaa gttcaagcag     1260

agtacacaca gcatatatat gttcttcaac acatcagagc tccgagaagc ggtacctgaa     1320

cccgtgttgc tctcccgggc agagctgcgt ctgctgaggc tcaagttaaa agtggagcag     1380

cacgtggagc tgtaccagaa atacagcaac aattcctggc gatacctcag caaccggctg     1440

ctggcaccca gcgactcgcc agagtggtta tcttttgatg tcaccggagt tgtgcggcag     1500

tggttgagcc gtggagggga aattgagggc tttcgcctta gcgcccactg ctcctgtgac     1560

agcagggata acacactgca agtggacatc aacgggttca ctaccggccg ccgaggtgac     1620

ctggccacca ttcatggcat gaaccggcct ttcctgcttc tcatggccac cccgctggag     1680

agggcccagc atctgcaaag ctcccggcac cgccgagccc tggacaccaa ctattgcttc     1740

agctccacgg agaagaactg ctgcgtgcgg cagctgtaca ttgacttccg caaggacctc     1800

ggctggaagt ggatccacga gcccaagggc taccatgcca acttctgcct cgggccctgc     1860

ccctacattt ggagcctgga cacgcagtac agcaaggtcc tggccctgta caaccagcat     1920

aacccgggcg cctcggcggc gccgtgctgc gtgccgcagg cgctggagcc gctgcccatc     1980

gtgtactacg tgggccgcaa gcccaaggtg gagcagctgt ccaacatgat cgtgcgctcc     2040

tgcaagtgca gctgaggtcc cgccccgccc cgccccgccc cggcaggccc ggccccaccc     2100

cgccccgccc ccgctgcctt gcccatgggg gctgtattta aggacacccg tgccccaagc     2160

ccacctgggg ccccattaaa gatggagaga ggactgcgga aaaaaaaaaa aaaaaaa        2217


<210>  32
<211>  6774
<212>  DNA
<213>  Homo sapiens

<400>  32
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc       60

gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg      120

ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt      180

gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc      240

gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga      300

ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc      360

ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc      420

gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga      480

gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc      540

acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc      600

ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc      660

aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta      720

tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg      780

aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg      840

tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag      900

ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat      960

ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat     1020

gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta     1080

accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata     1140

ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc     1200

tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa     1260

tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct     1320

tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt     1380

tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt     1440

aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat     1500

acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt     1560

cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg     1620

aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg     1680

tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa     1740

aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat     1800

tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct     1860

caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca     1920

agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata     1980

tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt     2040

aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt     2100

tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc     2160

ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa     2220

ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa     2280

tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat     2340

ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca     2400

aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt     2460

cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt     2520

ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa     2580

gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta     2640

ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg     2700

gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcgtct gccatttttc     2760

aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa     2820

caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct     2880

gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg     2940

tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt     3000

ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa     3060

ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt     3120

gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat     3180

acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata     3240

tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg     3300

aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat     3360

ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta     3420

tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc     3480

tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc     3540

agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta     3600

acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt     3660

atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat     3720

tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata     3780

ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac     3840

taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt     3900

ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat     3960

atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg     4020

ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc     4080

tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt     4140

aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt     4200

tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa     4260

acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac     4320

aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt     4380

tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat     4440

ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag     4500

ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta     4560

gctgctttca gggttttatg aattttcagg caaagcttta atttatacta agcttaggaa     4620

gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat     4680

gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa     4740

aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc     4800

ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag     4860

tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa     4920

aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata     4980

gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc     5040

accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc     5100

acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg     5160

tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg     5220

atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt     5280

ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag     5340

aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa     5400

ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg     5460

aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc     5520

tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg     5580

agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt     5640

actatgtttt gacttcctga ctattaaaaa taaatagtag atacaatttt cataaagtga     5700

agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta     5760

aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat     5820

tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat     5880

atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag     5940

gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta     6000

tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa     6060

attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc     6120

ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct     6180

ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata     6240

aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat     6300

tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc     6360

atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc     6420

caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat     6480

gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct     6540

agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat     6600

aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca     6660

gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt     6720

gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tccc           6774


<210>  33
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  34
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Val Gly Gln Ser Pro Ala Ala Val Gly Leu Gly Ala Gly 
            340                 345                 350         


Glu Gln Gly Gly Thr 
        355         


<210>  35
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Ala Leu Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn 
            260                 265                 270         


Lys Arg Ile Thr Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln 
        275                 280                 285             


Tyr Tyr Asp Pro Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe 
    290                 295                 300                 


Ala Met Glu Leu Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile 
305                 310                 315                 320 


Phe Gln Glu Thr Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
                325                 330                 335 


<210>  36
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  36

Pro Arg Arg Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu 
1               5                   10                  15      


Met Val Lys Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu 
            20                  25                  30          


Gln Tyr Ile Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp 
        35                  40                  45              


His Val Arg Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu 
    50                  55                  60                  


His Gln Thr Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu 
65                  70                  75                  80  


Arg Phe Arg His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala 
                85                  90                  95      


Ser Thr Leu Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met 
            100                 105                 110         


Glu Thr Asp Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp 
        115                 120                 125             


His Ile Cys Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile 
    130                 135                 140                 


His Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu 
145                 150                 155                 160 


Ile Asn Thr Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Ile Ala Asp Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val 
            180                 185                 190         


Ala Thr Arg Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly 
        195                 200                 205             


Tyr Thr Lys Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu 
    210                 215                 220                 


Met Leu Ser Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln 
225                 230                 235                 240 


Leu Asn His Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu 
                245                 250                 255     


Asn Cys Ile Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro 
            260                 265                 270         


Ser Lys Thr Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser 
        275                 280                 285             


Lys Ala Leu Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys 
    290                 295                 300                 


Arg Ile Thr Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr 
305                 310                 315                 320 


Tyr Asp Pro Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala 
                325                 330                 335     


Met Glu Leu Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe 
            340                 345                 350         


Gln Glu Thr Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
        355                 360                 365     


<210>  37
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  38
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  39
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asn Gln Leu Gln Gln Ile Met Arg Leu Thr Gly 
225                 230                 235                 240 


Thr Pro Pro Ala Tyr Leu Ile Asn Arg Met Pro Ser His Glu Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  40
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  41
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Gly Lys Leu Thr Ile Tyr Pro His 
        275                 280                 285             


Leu Met Asp Ile Glu Leu Val Met Ile 
    290                 295         


<210>  42
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Leu Ser 
                245                 250                 255     


Thr Cys Trp Arg Arg Cys Leu Tyr Trp Thr Gln Ile Arg Glu Leu Gln 
            260                 265                 270         


Arg Pro Lys Pro Leu His Met Pro Thr Leu Leu Ser Thr Thr Ile Leu 
        275                 280                 285             


Met Met Asn Gln Trp Pro Ile Leu Met Ile Ser Pro Leu Lys Ala Gly 
    290                 295                 300                 


Thr Ser Leu 
305         


<210>  43
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Gly Pro Arg Ala Gly Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Val Trp Glu Val Pro Gln Arg Leu Gln Gly Leu Arg Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ser Ala Tyr Asp Ala Arg Leu Arg Gln 
        35                  40                  45              


Lys Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Leu Ile His 
    50                  55                  60                  


Ala Arg Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Leu Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Thr Ser Ile 
                85                  90                  95      


Glu Asp Phe Ser Glu Val Tyr Leu Val Thr Thr Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Ala Leu Ser Asp Glu His Val Gln 
        115                 120                 125             


Phe Leu Val Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Val Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Arg Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Asp 
                165                 170                 175     


Glu Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Gln Gly Lys Ala Leu Phe Pro 
    210                 215                 220                 


Gly Ser Asp Tyr Ile Asp Gln Leu Lys Arg Ile Met Glu Val Val Gly 
225                 230                 235                 240 


Thr Pro Ser Pro Glu Val Leu Ala Lys Ile Ser Ser Glu His Ala Arg 
                245                 250                 255     


Thr Tyr Ile Gln Ser Leu Pro Pro Met Pro Gln Lys Asp Leu Ser Ser 
            260                 265                 270         


Ile Phe Arg Gly Ala Asn Pro Leu Ala Ile Asp Leu Leu Gly Arg Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Gln Arg Val Ser Ala Ala Glu Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ser Gln Tyr His Asp Pro Glu Asp Glu Pro Glu Ala 
305                 310                 315                 320 


Glu Pro Tyr Asp Glu Ser Val Glu Ala Lys Glu Arg Thr Leu Glu Glu 
                325                 330                 335     


Trp Lys Glu Leu Thr Tyr Gln Glu Val Leu Ser Phe Lys Pro Pro Glu 
            340                 345                 350         


Pro Pro Lys Pro Pro Gly Ser Leu Glu Ile Glu Gln 
        355                 360                 


<210>  44
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      


Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          


Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              


Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  


Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  


Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      


Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 
    130                 135                 140                 


His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 
145                 150                 155                 160 


Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 
        195                 200                 205             


Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 
    210                 215                 220                 


Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 
225                 230                 235                 240 


Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 
                245                 250                 255     


Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 
            260                 265                 270         


Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro Leu Ala Val Asn Leu Leu 
        275                 280                 285             


Glu Lys Met Leu Val Leu Asp Ala Glu Gln Arg Val Thr Ala Gly Glu 
    290                 295                 300                 


Ala Leu Ala His Pro Tyr Phe Glu Ser Leu His Asp Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe Asp Asp Val Asp Arg Thr 
                325                 330                 335     


Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys 
            340                 345                 350         


Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
        355                 360                 365         


<210>  45
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  46
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  47
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  48
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  49
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  50
<211>  1354
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn 
1               5                   10                  15      


Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
            20                  25                  30          


Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
        35                  40                  45              


Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
    50                  55                  60                  


Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                85                  90                  95      


Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
            100                 105                 110         


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
        115                 120                 125             


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
145                 150                 155                 160 


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                165                 170                 175     


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
            180                 185                 190         


Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
        195                 200                 205             


Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
    210                 215                 220                 


Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
225                 230                 235                 240 


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                245                 250                 255     


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
            260                 265                 270         


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
        275                 280                 285             


Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
    290                 295                 300                 


Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
305                 310                 315                 320 


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                325                 330                 335     


Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
            340                 345                 350         


Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
        355                 360                 365             


Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro 
    370                 375                 380                 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr 
                405                 410                 415     


Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile 
            420                 425                 430         


Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
        435                 440                 445             


Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
    450                 455                 460                 


Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr 
465                 470                 475                 480 


Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                485                 490                 495     


Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
            500                 505                 510         


Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys 
        515                 520                 525             


Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
545                 550                 555                 560 


Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser 
                565                 570                 575     


Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu 
            580                 585                 590         


Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
        595                 600                 605             


Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
    610                 615                 620                 


Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
625                 630                 635                 640 


Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln 
                645                 650                 655     


Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
            660                 665                 670         


Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val 
        675                 680                 685             


Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
    690                 695                 700                 


Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
705                 710                 715                 720 


Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln 
                725                 730                 735     


Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
            740                 745                 750         


Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu 
        755                 760                 765             


Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu 
    770                 775                 780                 


Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
785                 790                 795                 800 


Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                805                 810                 815     


Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
            820                 825                 830         


Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
        835                 840                 845             


Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
    850                 855                 860                 


Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu 
865                 870                 875                 880 


Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu 
                885                 890                 895     


Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln 
            900                 905                 910         


Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
        915                 920                 925             


Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
    930                 935                 940                 


Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu 
945                 950                 955                 960 


Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu 
                965                 970                 975     


Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
            980                 985                 990         


Asn Thr Glu Arg Thr Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu 
        995                 1000                 1005             


Ile Met  Asn Arg Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn 
    1010                 1015                 1020             


Thr Gln  Asp Leu Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln 
    1025                 1030                 1035             


Leu Glu  Leu Asn Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val 
    1040                 1045                 1050             


Lys His  Gln Lys Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu 
    1055                 1060                 1065             


Glu Cys  Ala His Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys 
    1070                 1075                 1080             


Glu Ser  Asp Ile Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser 
    1085                 1090                 1095             


Asp Ser  Thr Ser Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp 
    1100                 1105                 1110             


Gly Asn  Leu Pro Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro 
    1115                 1120                 1125             


Asn Arg  Gly Asn Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val 
    1130                 1135                 1140             


Val Val  Ser Ser Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp 
    1145                 1150                 1155             


Lys Glu  Gln Ser Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu 
    1160                 1165                 1170             


Phe His  Val Arg Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Ile Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu 
    1190                 1195                 1200             


Gly Glu  Cys Arg Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala 
    1205                 1210                 1215             


Glu Lys  Thr Asn Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro 
    1220                 1225                 1230             


Thr Leu  Tyr His Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro 
    1235                 1240                 1245             


Leu Trp  His Val Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg 
    1250                 1255                 1260             


Cys His  Val Lys Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp 
    1265                 1270                 1275             


Leu Ile  Cys Pro Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg 
    1280                 1285                 1290             


Asp Met  Leu Leu Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp 
    1295                 1300                 1305             


Val Thr  His Leu Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly 
    1310                 1315                 1320             


Phe Val  Arg Ala Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala 
    1325                 1330                 1335             


Asn Gln  Ser Phe Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr 
    1340                 1345                 1350             


Ser 
    


<210>  51
<211>  1388
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210>  52
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  SiRNA oligonucleotide

<400>  52
aggucaaggg caagcccgac cugaa                                             25


<210>  53
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  SiRNA oligonucleotide

<400>  53
uucaggucgg gcuugcccuu gaccu                                             25


<210>  54
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  55
<211>  1411
<212>  DNA
<213>  Homo sapiens

<400>  55
ccttcgcaag ccctcatttc accaggcccc cggcttgggg cgccttcctt ccccatggcg       60

ggacacctgg cttcggattt cgccttctcg ccccctccag gtggtggagg tgatgggcca      120

ggggggccgg agccgggctg ggttgatcct cggacctggc taagcttcca aggccctcct      180

ggagggccag gaatcgggcc gggggttggg ccaggctctg aggtgtgggg gattccccca      240

tgccccccgc cgtatgagtt ctgtgggggg atggcgtact gtgggcccca ggttggagtg      300

gggctagtgc cccaaggcgg cttggagacc tctcagcctg agggcgaagc aggagtcggg      360

gtggagagca actccgatgg ggcctccccg gagccctgca ccgtcacccc tggtgccgtg      420

aagctggaga aggagaagct ggagcaaaac ccggaggagt cccaggacat caaagctctg      480

cagaaagaac tcgagcaatt tgccaagctc ctgaagcaga agaggatcac cctgggatat      540

acacaggccg atgtggggct caccctgggg gttctatttg ggaaggtatt cagccaaacg      600

accatctgcc gctttgaggc tctgcagctt agcttcaaga acatgtgtaa gctgcggccc      660

ttgctgcaga agtgggtgga ggaagctgac aacaatgaaa atcttcagga gatatgcaaa      720

gcagaaaccc tcgtgcaggc ccgaaagaga aagcgaacca gtatcgagaa ccgagtgaga      780

ggcaacctgg agaatttgtt cctgcagtgc ccgaaaccca cactgcagca gatcagccac      840

atcgcccagc agcttgggct cgagaaggat gtggtccgag tgtggttctg taaccggcgc      900

cagaagggca agcgatcaag cagcgactat gcacaacgag aggattttga ggctgctggg      960

tctcctttct cagggggacc agtgtccttt cctctggccc cagggcccca ttttggtacc     1020

ccaggctatg ggagccctca cttcactgca ctgtactcct cggtcccttt ccctgagggg     1080

gaagcctttc cccctgtctc cgtcaccact ctgggctctc ccatgcattc aaactgaggt     1140

gcctgccctt ctaggaatgg gggacagggg gaggggagga gctagggaaa gaaaacctgg     1200

agtttgtgcc agggtttttg ggattaagtt cttcattcac taaggaagga attgggaaca     1260

caaagggtgg gggcagggga gtttggggca actggttgga gggaaggtga agttcaatga     1320

tgctcttgat tttaatccca catcatgtat cacttttttc ttaaataaag aagcctggga     1380

cacagtagat agacacactt aaaaaaaaaa a                                    1411


<210>  56
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  57
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  57
ggatggttgt ctattaactt gttcaaaaaa gtatcaggag ttgtcaaggc agagaagaga       60

gtgtttgcaa aagggggaaa gtagtttgct gcctctttaa gactaggact gagagaaaga      120

agaggagaga gaaagaaagg gagagaagtt tgagccccag gcttaagcct ttccaaaaaa      180

taataataac aatcatcggc ggcggcagga tcggccagag gaggagggaa gcgctttttt      240

tgatcctgat tccagtttgc ctctctcttt ttttccccca aattattctt cgcctgattt      300

tcctcgcgga gccctgcgct cccgacaccc ccgcccgcct cccctcctcc tctccccccg      360

cccgcgggcc ccccaaagtc ccggccgggc cgagggtcgg cggccgccgg cgggccgggc      420

ccgcgcacag cgcccgcatg tacaacatga tggagacgga gctgaagccg ccgggcccgc      480

agcaaacttc ggggggcggc ggcggcaact ccaccgcggc ggcggccggc ggcaaccaga      540

aaaacagccc ggaccgcgtc aagcggccca tgaatgcctt catggtgtgg tcccgcgggc      600

agcggcgcaa gatggcccag gagaacccca agatgcacaa ctcggagatc agcaagcgcc      660

tgggcgccga gtggaaactt ttgtcggaga cggagaagcg gccgttcatc gacgaggcta      720

agcggctgcg agcgctgcac atgaaggagc acccggatta taaataccgg ccccggcgga      780

aaaccaagac gctcatgaag aaggataagt acacgctgcc cggcgggctg ctggcccccg      840

gcggcaatag catggcgagc ggggtcgggg tgggcgccgg cctgggcgcg ggcgtgaacc      900

agcgcatgga cagttacgcg cacatgaacg gctggagcaa cggcagctac agcatgatgc      960

aggaccagct gggctacccg cagcacccgg gcctcaatgc gcacggcgca gcgcagatgc     1020

agcccatgca ccgctacgac gtgagcgccc tgcagtacaa ctccatgacc agctcgcaga     1080

cctacatgaa cggctcgccc acctacagca tgtcctactc gcagcagggc acccctggca     1140

tggctcttgg ctccatgggt tcggtggtca agtccgaggc cagctccagc ccccctgtgg     1200

ttacctcttc ctcccactcc agggcgccct gccaggccgg ggacctccgg gacatgatca     1260

gcatgtatct ccccggcgcc gaggtgccgg aacccgccgc ccccagcaga cttcacatgt     1320

cccagcacta ccagagcggc ccggtgcccg gcacggccat taacggcaca ctgcccctct     1380

cacacatgtg agggccggac agcgaactgg aggggggaga aattttcaaa gaaaaacgag     1440

ggaaatggga ggggtgcaaa agaggagagt aagaaacagc atggagaaaa cccggtacgc     1500

tcaaaaagaa aaaggaaaaa aaaaaatccc atcacccaca gcaaatgaca gctgcaaaag     1560

agaacaccaa tcccatccac actcacgcaa aaaccgcgat gccgacaaga aaacttttat     1620

gagagagatc ctggacttct ttttggggga ctatttttgt acagagaaaa cctggggagg     1680

gtggggaggg cgggggaatg gaccttgtat agatctggag gaaagaaagc tacgaaaaac     1740

tttttaaaag ttctagtggt acggtaggag ctttgcagga agtttgcaaa agtctttacc     1800

aataatattt agagctagtc tccaagcgac gaaaaaaatg ttttaatatt tgcaagcaac     1860

ttttgtacag tatttatcga gataaacatg gcaatcaaaa tgtccattgt ttataagctg     1920

agaatttgcc aatatttttc aaggagaggc ttcttgctga attttgattc tgcagctgaa     1980

atttaggaca gttgcaaacg tgaaaagaag aaaattattc aaatttggac attttaattg     2040

tttaaaaatt gtacaaaagg aaaaaattag aataagtact ggcgaaccat ctctgtggtc     2100

ttgtttaaaa agggcaaaag ttttagactg tactaaattt tataacttac tgttaaaagc     2160

aaaaatggcc atgcaggttg acaccgttgg taatttataa tagcttttgt tcgatcccaa     2220

ctttccattt tgttcagata aaaaaaacca tgaaattact gtgtttgaaa tattttctta     2280

tggtttgtaa tatttctgta aatttattgt gatattttaa ggttttcccc cctttatttt     2340

ccgtagttgt attttaaaag attcggctct gtattatttg aatcagtctg ccgagaatcc     2400

atgtatatat ttgaactaat atcatcctta taacaggtac attttcaact taagttttta     2460

ctccattatg cacagtttga gataaataaa tttttgaaat atggacactg aaaaaaaaaa     2520


<210>  58
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  59
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  59
agtttcccga ccagagagaa cgaacgtgtc tgcgggcgcg cggggagcag aggcggtggc       60

gggcggcggc ggcaccggga gccgccgagt gaccctcccc cgcccctctg gccccccacc      120

ctcccacccg cccgtggccc gcgcccatgg ccgcgcgcgc tccacacaac tcaccggagt      180

ccgcgccttg cgccgccgac cagttcgcag ctccgcgcca cggcagccag tctcacctgg      240

cggcaccgcc cgcccaccgc cccggccaca gcccctgcgc ccacggcagc actcgaggcg      300

accgcgacag tggtggggga cgctgctgag tggaagagag cgcagcccgg ccaccggacc      360

tacttactcg ccttgctgat tgtctatttt tgcgtttaca acttttctaa gaacttttgt      420

atacaaagga actttttaaa aaagacgctt ccaagttata tttaatccaa agaagaagga      480

tctcggccaa tttggggttt tgggttttgg cttcgtttct tctcttcgtt gactttgggg      540

ttcaggtgcc ccagctgctt cgggctgccg aggaccttct gggcccccac attaatgagg      600

cagccacctg gcgagtctga catggctgtc agcgacgcgc tgctcccatc tttctccacg      660

ttcgcgtctg gcccggcggg aagggagaag acactgcgtc aagcaggtgc cccgaataac      720

cgctggcggg aggagctctc ccacatgaag cgacttcccc cagtgcttcc cggccgcccc      780

tatgacctgg cggcggcgac cgtggccaca gacctggaga gcggcggagc cggtgcggct      840

tgcggcggta gcaacctggc gcccctacct cggagagaga ccgaggagtt caacgatctc      900

ctggacctgg actttattct ctccaattcg ctgacccatc ctccggagtc agtggccgcc      960

accgtgtcct cgtcagcgtc agcctcctct tcgtcgtcgc cgtcgagcag cggccctgcc     1020

agcgcgccct ccacctgcag cttcacctat ccgatccggg ccgggaacga cccgggcgtg     1080

gcgccgggcg gcacgggcgg aggcctcctc tatggcaggg agtccgctcc ccctccgacg     1140

gctcccttca acctggcgga catcaacgac gtgagcccct cgggcggctt cgtggccgag     1200

ctcctgcggc cagaattgga cccggtgtac attccgccgc agcagccgca gccgccaggt     1260

ggcgggctga tgggcaagtt cgtgctgaag gcgtcgctga gcgcccctgg cagcgagtac     1320

ggcagcccgt cggtcatcag cgtcagcaaa ggcagccctg acggcagcca cccggtggtg     1380

gtggcgccct acaacggcgg gccgccgcgc acgtgcccca agatcaagca ggaggcggtc     1440

tcttcgtgca cccacttggg cgctggaccc cctctcagca atggccaccg gccggctgca     1500

cacgacttcc ccctggggcg gcagctcccc agcaggacta ccccgaccct gggtcttgag     1560

gaagtgctga gcagcaggga ctgtcaccct gccctgccgc ttcctcccgg cttccatccc     1620

cacccggggc ccaattaccc atccttcctg cccgatcaga tgcagccgca agtcccgccg     1680

ctccattacc aagagctcat gccacccggt tcctgcatgc cagaggagcc caagccaaag     1740

aggggaagac gatcgtggcc ccggaaaagg accgccaccc acacttgtga ttacgcgggc     1800

tgcggcaaaa cctacacaaa gagttcccat ctcaaggcac acctgcgaac ccacacaggt     1860

gagaaacctt accactgtga ctgggacggc tgtggatgga aattcgcccg ctcagatgaa     1920

ctgaccaggc actaccgtaa acacacgggg caccgcccgt tccagtgcca aaaatgcgac     1980

cgagcatttt ccaggtcgga ccacctcgcc ttacacatga agaggcattt ttaaatccca     2040

gacagtggat atgacccaca ctgccagaag agaattcagt attttttact tttcacactg     2100

tcttcccgat gagggaagga gcccagccag aaagcactac aatcatggtc aagttcccaa     2160

ctgagtcatc ttgtgagtgg ataatcagga aaaatgagga atccaaaaga caaaaatcaa     2220

agaacagatg gggtctgtga ctggatcttc tatcattcca attctaaatc cgacttgaat     2280

attcctggac ttacaaaatg ccaagggggt gactggaagt tgtggatatc agggtataaa     2340

ttatatccgt gagttggggg agggaagacc agaattccct tgaattgtgt attgatgcaa     2400

tataagcata aaagatcacc ttgtattctc tttaccttct aaaagccatt attatgatgt     2460

tagaagaaga ggaagaaatt caggtacaga aaacatgttt aaatagccta aatgatggtg     2520

cttggtgagt cttggttcta aaggtaccaa acaaggaagc caaagttttc aaactgctgc     2580

atactttgac aaggaaaatc tatatttgtc ttccgatcaa catttatgac ctaagtcagg     2640

taatatacct ggtttacttc tttagcattt ttatgcagac agtctgttat gcactgtggt     2700

ttcagatgtg caataatttg tacaatggtt tattcccaag tatgccttaa gcagaacaaa     2760

tgtgtttttc tatatagttc cttgccttaa taaatatgta atataaattt aagcaaacgt     2820

ctattttgta tatttgtaaa ctacaaagta aaatgaacat tttgtggagt ttgtattttg     2880

catactcaag gtgagaatta agttttaaat aaacctataa tattttatct gaaaaaaaaa     2940

aaaaaaaaa                                                             2949


<210>  60
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  61
<211>  2379
<212>  DNA
<213>  Homo sapiens

<400>  61
gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc       60

ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag      120

ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc      180

cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag      240

agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg      300

gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa      360

ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac      420

gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc      480

caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacgctgga tttttttcgg      540

gtagtggaaa accagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg      600

aactatgacc tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac      660

ttctaccagc agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg      720

aagaaattcg agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc      780

tcgccctcct acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc      840

gggagcttct ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg      900

gtgaaccaga gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc      960

caggactgta tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc     1020

tcctaccagg ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc     1080

tgctccacct ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac     1140

ccctcggtgg tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg     1200

caagactcca gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc     1260

ccgcagggca gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc     1320

gactctgagg aggaacaaga agatgaggaa gaaatcgatg ttgtttctgt ggaaaagagg     1380

caggctcctg gcaaaaggtc agagtctgga tcaccttctg ctggaggcca cagcaaacct     1440

cctcacagcc cactggtcct caagaggtgc cacgtctcca cacatcagca caactacgca     1500

gcgcctccct ccactcggaa ggactatcct gctgccaaga gggtcaagtt ggacagtgtc     1560

agagtcctga gacagatcag caacaaccga aaatgcacca gccccaggtc ctcggacacc     1620

gaggagaatg tcaagaggcg aacacacaac gtcttggagc gccagaggag gaacgagcta     1680

aaacggagct tttttgccct gcgtgaccag atcccggagt tggaaaacaa tgaaaaggcc     1740

cccaaggtag ttatccttaa aaaagccaca gcatacatcc tgtccgtcca agcagaggag     1800

caaaagctca tttctgaaga ggacttgttg cggaaacgac gagaacagtt gaaacacaaa     1860

cttgaacagc tacggaactc ttgtgcgtaa ggaaaagtaa ggaaaacgat tccttctaac     1920

agaaatgtcc tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc     1980

acaaccttgg ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt     2040

ggactttggg cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat     2100

ttgtatttaa gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata     2160

ttgccattaa atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat     2220

cctagtatat agtacctagt attataggta ctataaaccc taattttttt tatttaagta     2280

cattttgctt tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc     2340

aaatatatca ttgagccaaa tcttaaaaaa aaaaaaaaa                            2379


<210>  62
<211>  5489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  OSKM expression cassette: OCT4-F2A-KLF4-IRES-SOX2-E2A SEQUENCE

<400>  62
atggctggac acctggcttc agacttcgcc ttctcacccc caccaggtgg gggtgatggg       60

tcagcagggc tggagccggg ctgggtggat cctcgaacct ggctaagctt ccaagggcct      120

ccaggtgggc ctggaatcgg accaggctca gaggtattgg ggatctcccc atgtccgccc      180

gcatacgagt tctgcggagg gatggcatac tgtggacctc aggttggact gggcctagtc      240

ccccaagttg gcgtggagac tttgcagcct gagggccagg caggagcacg agtggaaagc      300

aactcagagg gaacctcctc tgagccctgt gccgaccgcc ccaatgccgt gaagttggag      360

aaggtggaac caactcccga ggagtcccag gacatgaaag ccctgcagaa ggagctagaa      420

cagtttgcca agctgctgaa gcagaagagg atcaccttgg ggtacaccca ggccgacgtg      480

gggctcaccc tgggcgttct ctttggaaag gtgttcagcc agaccaccat ctgtcgcttc      540

gaggccttgc agctcagcct taagaacatg tgtaagctgc ggcccctgct ggagaagtgg      600

gtggaggaag ccgacaacaa tgagaacctt caggagatat gcaaatcgga gaccctggtg      660

caggcccgga agagaaagcg aactagcatt gagaaccgtg tgaggtggag tctggagacc      720

atgtttctga agtgcccgaa gccctcccta cagcagatca ctcacatcgc caatcagctt      780

gggctagaga aggatgtggt tcgagtatgg ttctgtaacc ggcgccagaa gggcaaaaga      840

tcaagtattg agtattccca acgagaagag tatgaggcta cagggacacc tttcccaggg      900

ggggctgtat cctttcctct gcccccaggt ccccactttg gcaccccagg ctatggaagc      960

ccccacttca ccacactcta ctcagtccct tttcctgagg gcgaggcctt tccctctgtt     1020

cccgtcactg ctctgggctc tcccatgcat tcaaacggaa gtggcgtgaa acagactttg     1080

aattttgacc ttctcaagtt ggcgggagac gtggagtcca acccagggcc catggctgtc     1140

agcgacgctc tgctcccgtc cttctccacg ttcgcgtccg gcccggcggg aagggagaag     1200

acactgcgtc cagcaggtgc cccgactaac cgttggcgtg aggaactctc tcacatgaag     1260

cgacttcccc cacttcccgg ccgcccctac gacctggcgg cgacggtggc cacagacctg     1320

gagagtggcg gagctggtgc agcttgcagc agtaacaacc cggccctcct agcccggagg     1380

gagaccgagg agttcaacga cctcctggac ctagacttta tcctttccaa ctcgctaacc     1440

caccaggaat cggtggccgc caccgtgacc acctcggcgt cagcttcatc ctcgtcttcc     1500

ccagcgagca gcggccctgc cagcgcgccc tccacctgca gcttcagcta tccgatccgg     1560

gccgggggtg acccgggcgt ggctgccagc aacacaggtg gagggctcct ctacagccga     1620

gaatctgcgc cacctcccac ggcccccttc aacctggcgg acatcaatga cgtgagcccc     1680

tcgggcggct tcgtggctga gctcctgcgg ccggagttgg acccagtata cattccgcca     1740

cagcagcctc agccgccagg tggcgggctg atgggcaagt ttgtgctgaa ggcgtctctg     1800

accacccctg gcagcgagta cagcagccct tcggtcatca gtgttagcaa aggaagccca     1860

gacggcagcc accccgtggt agtggcgccc tacagcggtg gcccgccgcg catgtgcccc     1920

aagattaagc aagaggcggt cccgtcctgc acggtcagcc ggtccctaga ggcccatttg     1980

agcgctggac cccagctcag caacggccac cggcccaaca cacacgactt ccccctgggg     2040

cggcagctcc ccaccaggac tacccctaca ctgagtcccg aggaactgct gaacagcagg     2100

gactgtcacc ctggcctgcc tcttccccca ggattccatc cccatccggg gcccaactac     2160

cctcctttcc tgccagacca gatgcagtca caagtcccct ctctccatta tcaagagctc     2220

atgccaccgg gttcctgcct gccagaggag cccaagccaa agaggggaag aaggtcgtgg     2280

ccccggaaaa gaacagccac ccacacttgt gactatgcag gctgtggcaa aacctatacc     2340

aagagttctc atctcaaggc acacctgcga actcacacag gcgagaaacc ttaccactgt     2400

gactgggacg gctgtgggtg gaaattcgcc cgctccgatg aactgaccag gcactaccgc     2460

aaacacacag ggcaccggcc ctttcagtgc cagaagtgtg acagggcctt ttccaggtcg     2520

gaccaccttg ccttacacat gaagaggcac ttttaaagat ccctcccccc cccctaacgt     2580

tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac     2640

catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag     2700

cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa     2760

ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag     2820

gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga     2880

tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag     2940

agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc     3000

ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag     3060

gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg     3120

atgataatat ggccacacat atgatgtata acatgatgga gacggagctg aagccgccgg     3180

gcccgcagca agcttcgggg ggcggcggcg gaggaggcaa cgccacggcg gcggcgaccg     3240

gcggcaacca gaagaacagc ccggaccgcg tcaagaggcc catgaacgcc ttcatggtat     3300

ggtcccgggg gcagcggcgt aagatggccc aggagaaccc caagatgcac aactcggaga     3360

tcagcaagcg cctgggcgcg gagtggaaac ttttgtccga gaccgagaag cggccgttca     3420

tcgacgaggc caagcggctg cgcgctctgc acatgaagga gcacccggat tataaatacc     3480

ggccgcggcg gaaaaccaag acgctcatga agaaggataa gtacacgctt cccggaggct     3540

tgctggcccc cggcgggaac agcatggcga gcggggttgg ggtgggcgcc ggcctgggtg     3600

cgggcgtgaa ccagcgcatg gacagctacg cgcacatgaa cggctggagc aacggcagct     3660

acagcatgat gcaggagcag ctgggctacc cgcagcaccc gggcctcaac gctcacggcg     3720

cggcacagat gcaaccgatg caccgctacg acgtcagcgc cctgcagtac aactccatga     3780

ccagctcgca gacctacatg aacggctcgc ccacctacag catgtcctac tcgcagcagg     3840

gcacccccgg tatggcgctg ggctccatgg gctctgtggt caagtccgag gccagctcca     3900

gcccccccgt ggttacctct tcctcccact ccagggcgcc ctgccaggcc ggggacctcc     3960

gggacatgat cagcatgtac ctccccggcg ccgaggtgcc ggagcccgct gcgcccagta     4020

gactgcacat ggcccagcac taccagagcg gcccggtgcc cggcacggcc attaacggca     4080

cactgcccct gtcgcacatg ggtagtgggc aatgtactaa ctacgctttg ttgaaactcg     4140

ctggcgatgt tgaaagtaac cccggtccta tgcccctcaa cgtgaacttc accaacagga     4200

actatgacct cgactacgac tccgtacagc cctatttcat ctgcgacgag gaagagaatt     4260

tctatcacca gcaacagcag agcgagctgc agccgcccgc gcccagtgag gatatctgga     4320

agaaattcga gctgcttccc accccgcccc tgtccccgag ccgccgctcc gggctctgct     4380

ctccatccta tgttgcggtc gctacgtcct tctccccaag ggaagacgat gacggcggcg     4440

gtggcaactt ctccaccgcc gatcagctgg agatgatgac cgagttactt ggaggagaca     4500

tggtgaacca gagcttcatc tgcgatcctg acgacgagac cttcatcaag aacatcatca     4560

tccaggactg tatgtggagc ggtttctcag ccgctgccaa gctggtctcg gagaagctgg     4620

cctcctacca ggctgcgcgc aaagacagca ccagcctgag ccccgcccgc gggcacagcg     4680

tctgctccac ctccagcctg tacctgcagg acctcaccgc cgccgcgtcc gagtgcattg     4740

acccctcagt ggtctttccc tacccgctca acgacagcag ctcgcccaaa tcctgtacct     4800

cgtccgattc cacggccttc tctccttcct cggactcgct gctgtcctcc gagtcctccc     4860

cacgggccag ccctgagccc ctagtgctgc atgaggagac accgcccacc accagcagcg     4920

actctgaaga agagcaagaa gatgaggaag aaattgatgt ggtgtctgtg gagaagaggc     4980

aaacccctgc caagaggtcg gagtcgggct catctccatc ccgaggccac agcaaacctc     5040

cgcacagccc actggtcctc aagaggtgcc acgtctccac tcaccagcac aactacgccg     5100

cacccccctc cacaaggaag gactatccag ctgccaagag ggccaagttg gacagtggca     5160

gggtcctgaa gcagatcagc aacaaccgca agtgctccag ccccaggtcc tcagacacgg     5220

aggaaaacga caagaggcgg acacacaacg tcttggaacg tcagaggagg aacgagctga     5280

agcgcagctt ttttgccctg cgtgaccaga tccctgaatt ggaaaacaac gaaaaggccc     5340

ccaaggtagt gatcctcaaa aaagccaccg cctacatcct gtccattcaa gcagacgagc     5400

acaagctcac ctctgaaaag gacttattga ggaaacgacg agaacagttg aaacacaaac     5460

tcgaacagct tcgaaactct ggtgcataa                                       5489


<210>  63
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  63
ccggctaagt ggattgagtg cctttctcga gaaaggcact caatccactt agtttttg         58


<210>  64
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  64
aattcaaaaa ctaagtggat tgagtgcctt tctcgagaaa ggcactcaat ccacttag         58


<210>  65
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  65
ccgggcgcta tgattcttcc aaccactcga gtggttggaa gaatcatagc gctttttg         58


<210>  66
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  66
aattcaaaaa gcgctatgat tcttccaacc actcgagtgg ttggaagaat catagcgc         58


<210>  67
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  67
acaactaacc taaaccaaat tataca                                            26


<210>  68
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  68
tgtttttttg tttatcgggg tcgcg                                             25


<210>  69
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  69
cgaattatac gacaaatcta aaataacg                                          28


<210>  70
<211>  203
<212>  DNA
<213>  Artificial sequence

<220>
<223>  203bp amplicon covering human XIST transcription start site

<400>  70
gggtaaattt tgaaccaacc aaatcacaaa gatgtccggc tttcaatctt ctaggccacg       60

cctcttatgc tctctccgcc ctcagccccc ccttcagttc ttaaagcgct gcaattcgct      120

gctgcagcca tatttcttac tctctcgggg ctggaagctt cctgactgaa gatctgttct      180

agaaagaacc ccaagtgcag aga                                              203


<210>  71
<211>  1902
<212>  DNA
<213>  Homo sapiens

<400>  71
atgaccgaag aagcatgccg aacacggagt cagaaacgag cgcttgaacg ggacccaaca       60

gaggacgatg tggagagcaa gaaaataaaa atggagagag gattgttggc ttcagattta      120

aacactgacg gagacatgag ggtgacacct gagccgggag caggtccaac ccaaggattg      180

ctgagggcaa cagaggccac ggccatggcc atgggcagag gcgaagggct ggtgggcgat      240

gggcccgtgg acatgcgcac ctcacacagt gacatgaagt ccgagaggag acccccctca      300

cctgacgtga ttgtgctctc cgacaacgag cagccctcga gcccgagagt gaatgggctg      360

accacggtgg ccttgaagga gactagcacc gaggccctca tgaaaagcag tcctgaagaa      420

cgagaaagga tgatcaagca gctgaaggaa gaattgaggt tagaagaagc aaaactcgtg      480

ttgttgaaaa agttgcggca gagtcaaata caaaaggaag ccaccgccca gaagcccaca      540

ggttctgttg ggagcaccgt gaccacccct cccccgcttg ttcggggcac tcagaacatt      600

cctgctggca agccatcact ccagacctct tcagctcgga tgcccggcag tgtcataccc      660

ccgcccctgg tccgaggtgg gcagcaggcg tcctcgaagc tggggccaca ggcgagctca      720

caggtcgtca tgcccccact cgtcaggggg gctcagcaaa tccacagcat taggcaacat      780

tccagcacag ggccaccgcc cctcctcctg gccccccggg cgtcggtgcc cagtgtgcag      840

attcagggac agaggatcat ccagcagggc ctcatccgcg tcgccaatgt tcccaacacc      900

agcctgctcg tcaacatccc acagcccacc ccagcatcac tgaaggggac aacagccacc      960

tccgctcagg ccaactccac ccccactagt gtggcctctg tggtcacctc tgccgagtct     1020

ccagcaagcc gacaggcggc cgccaagctg gcgctgcgca aacagctgga gaagacgcta     1080

ctcgagatcc ccccacccaa gcccccagcc ccagagatga acttcctgcc cagcgccgcc     1140

aacaacgagt tcatctacct ggtcggcctg gaggaggtgg tgcagaacct actggagaca     1200

caaggcagga tgtcggccgc cactgtgctg tcccgggagc cctacatgtg tgcacagtgc     1260

aagacggact tcacgtgccg ctggcgggag gagaagagcg gcgccatcat gtgtgagaac     1320

tgcatgacaa ccaaccagaa gaaggcgctc aaggtggagc acaccagccg gctgaaggcc     1380

gcctttgtga aggcgctgca gcaggaacag gagattgagc agcggctcct gcagcagggc     1440

acggcccctg cacaggccaa ggccgagccc accgctgccc cacaccccgt gctgaagcag     1500

gtcataaaac cccggcgtaa gttggcgttc cgctcaggag aggcccgcga ctggagtaac     1560

ggggctgtgc tacaggcctc cagccagctg tcccggggtt cggccacgac gccccgaggt     1620

gtcctgcaca cgttcagtcc gtcacccaaa ctgcagaact cagcctcggc cacagccctg     1680

gtcagcagga ccggcagaca ttctgagaga accgtgagcg ccggcaaggg cagcgccacc     1740

tccaactgga agaagacgcc cctcagcaca ggcgggaccc ttgcgtttgt cagcccaagc     1800

ctggcggtgc acaagagctc ctcggccgtg gaccgccagc gagagtacct cctggacatg     1860

atcccacccc gctccatccc ccagtcagcc acgtggaaat ag                        1902


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  72
cagggctgaa gagaagatgg                                                   20


<210>  73
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  73
acaggaggtg ggaatctga                                                    19


<210>  74
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  74
ggtaccggat actcaggcca ggcccagaaa                                        30


<210>  75
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  75
ctcgagtcca cagacctctg gcact                                             25


<210>  76
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  76
ggtacccatt gagtccaaat cctctttact aggtg                                  35


<210>  77
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  77
ctcgagctga ggctcatgct gctgg                                             25


<210>  78
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  78
agggagcagt ttgccctact                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  79
cacatgcagc gtggtatctt                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  80
agtgattctc ctgcctcagc                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  81
cttctgcttc aggagcttgg                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  82
ggaatgggag gacaggattt                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  83
aacagccgga gcagaagata                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  84
aaggatgttg aacgggcaga                                                   20


<210>  85
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  85
tccgttggaa ctgatgga                                                     18


<210>  86
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  86
tgacactggc aaaacaatgc a                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  87
ggtccttttc accagcaagc t                                                 21


<210>  88
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  88
cgccaccaaa ctgagatgat                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  89
cacattgtag tgggcagtgg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  90
cagtcgctac atcaccatcc                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  91
tttcctctcc tttgctctgc                                                   20


<210>  92
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  92
aactcaagaa ggcggatgg                                                    19


<210>  93
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  93
cggtgcgtcc tttaatcct                                                    19


<210>  94
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  94
cgcctcggct acaacaacta                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  95
cgcctcggct acaacaacta                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  96
aaacgtgctg ctctacgaca                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  97
tagtcgatga cgtgctggag                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  98
ctacagcgcg tcatcgacta                                                   20


<210>  99
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  99
tcgttggaga tgacaagttc c                                                 21


<210>  100
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  100
gcgctccgag aatttaaaga                                                   20


<210>  101
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  101
gtcgctgctg ttagcgaag                                                    19


<210>  102
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  102
gatttgtggg cctgaagaaa                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  103
cagatccatg gaggaaggaa                                                   20


<210>  104
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  104
agctgctgga gctcgtctt                                                    19


<210>  105
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  105
cgcctgttct ggaaccatac                                                   20


<210>  106
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  106
taaattttaa attaattaaa ttat                                              24


<210>  107
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  107
tgttttagaa agaattttaa gtgtagaga                                         29


<210>  108
<211>  2457
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  1st exon

<220>
<221>  misc_feature
<222>  (531)..(536)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1033)..(1038)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1051)..(1056)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1569)..(1574)
<223>  Premature polyA signal

<220>
<221>  misc_feature
<222>  (1669)..(2457)
<223>  2nd exon

<220>
<221>  misc_feature
<222>  (1712)..(1714)
<223>  Putative translation start site

<400>  108
accgtcgggg acccccaagc tccgtcctcc gcttcctgct ctctttatcc cgcccccgct       60

ccttctgggc caacgccgcc agtgactatt cccagggatc cctcagagct gaggacgccg      120

cggccgcatc cccatttggg accttgcccc gactccgacc tccggatctc cagctccacc      180

aaacctcgaa gccaccatcc gcccccaaac tgccgctgcg ccaggctttc ggaggggagt      240

cgtggcaaca gccattagga tgcactaagc agggcacttc ctgagcccaa ggacaccgag      300

gggcattcac tgagtgaatg gggatgtgct gctaataact aacactaatt gaccacctgc      360

cgtgtgccca tcctcttcga acatgcaact tccttgttcc ttatcttgtt actgtctctt      420

tctctctgcc agaatccaat cctcacaagg gcagggactg gggtctgttt tgttaactgc      480

catatcacaa tgcctggcac gaaggaagat tcttgaatta atgaatggag attaaattat      540

aatttaaaag cctggcatga actgagcacc ttctgcatgc ttatcacccg ctactgacat      600

atagttcact tttttttttt tttttttttt gagacggagt tttgctctta tctcccaggc      660

tggagtgcaa gtggtgtgat ctcagctcac tgcaacctcc gcctcccggg ttcaagcgat      720

tcttctgcct cagcctcccg agtagctggg attacaggcg tccaccacca ctcctggcta      780

atttttttgt gtttttatta gagacagggt ttcgcaatgt tgggcaggct ggtctcgaac      840

tcctgacctc aggtgatcca cccgactcgg cctccaaagt gctgggatta caggcgtgag      900

ccattgtgcc ccgccccctt tttaacctag tttgttgtct ctcaccccga ccagaatata      960

accttcatga gggctacagt ttgttgtcta tttattgccc aactccatgt ccttgccaca     1020

cagtaggttc ccaataaatg tatgttgaat aattaataaa gactacattc taatgataat     1080

ggctaacaga ccacgtgatt tacatattta tttggtttat tatattatct gcctctgcct     1140

tttagaacat aaaccttctg ggggtgggaa tgttgggtcc ctactgtctg gcaggcactg     1200

tgctgggcta gggttcaatg gtgaccaaaa ccggcaaaat cctgccctcc ctctgtcatg     1260

gggaggaact gctaatgggc atggggattc ttttctgggt gaggaaaatg ttctaaaatt     1320

tacttatggt gatagttgca caacttcgtg aatatgctaa aacccgttaa attggacact     1380

agctggctga acttgatggg atgtaaatta catctcaata aagctgtttg ggaaatccag     1440

ccttcacagt tgttgattcg cgtgaggagg gaaggagaga tggggggacg tgggacaggg     1500

agaaaacaac ataaatcata tatatatagc atgcaaattg gaaggtgatc agcacacaat     1560

aggcattcaa taaatgttga aataatgaca ccccactgtc tccttgccct caaatggtct     1620

cccctaacgt atcccctgtt gtcttgcttc ttctcttccc acttgcagag cctgctgccc     1680

acgtctcttc cctgagctgc ctgctggggt catggagctg ccaacaaagc ctggcacctt     1740

cgacctgggc ctggccacat ggagcccttc cttccagggg gaaacccacc gggctcaggc     1800

acgccgcagg gatgttggca ggcagctgcc tgagtacaag gctgtggtgg tgggcgccag     1860

tggcgtgggc aagagtgcgc tgaccatcca gctgaaccac cagtgcttcg tggaggacca     1920

cgaccccacc atccaggatt cctactggaa ggagttgacc ctggacagtg gggactgcat     1980

tctgaatgtg ctggacacag cagggcaggc catccatagg gccctgcgtg accagtgcct     2040

ggctgtctgt gatggtgtgc tgggcgtctt cgctctcgat gacccctcgt ctctgatcca     2100

gctgcagcag atatgggcca cctggggccc tcaccccgcc cagccccttg tcctcgtggg     2160

caacaagtgt gaccttgtga ccactgctgg agatgctcat gccgctgctg cagccctcgc     2220

acacagctgg ggggcccact tcgtggagac ctcggccaaa acacggcaag gcgtggagga     2280

ggccttttcc ctgctggtcc atgagatcca gagggtccag gaggccatgg cgaaggagcc     2340

catggcaagg tcctgtaggg agaagacccg gcaccagaag gccacctgcc actgtggctg     2400

ctctgtggcc tgaaggtctt ggccaagaaa tgtagacctt tccccaggcc agggtga        2457


<210>  109
<211>  826
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (81)..(83)
<223>  Putative translation start site

<400>  109
accgtcgggg acccccaagc tccgtcctcc gcttcctagc ctgctgccca cgtctcttcc       60

ctgagctgcc tgctggggtc atggagctgc caacaaagcc tggcaccttc gacctgggcc      120

tggccacatg gagcccttcc ttccaggggg aaacccaccg ggctcaggca cgccgcaggg      180

atgttggcag gcagctgcct gagtacaagg ctgtggtggt gggcgccagt ggcgtgggca      240

agagtgcgct gaccatccag ctgaaccacc agtgcttcgt ggaggaccac gaccccacca      300

tccaggattc ctactggaag gagttgaccc tggacagtgg ggactgcatt ctgaatgtgc      360

tggacacagc agggcaggcc atccataggg ccctgcgtga ccagtgcctg gctgtctgtg      420

atggtgtgct gggcgtcttc gctctcgatg acccctcgtc tctgatccag ctgcagcaga      480

tatgggccac ctggggccct caccccgccc agccccttgt cctcgtgggc aacaagtgtg      540

accttgtgac cactgctgga gatgctcatg ccgctgctgc agccctcgca cacagctggg      600

gggcccactt cgtggagacc tcggccaaaa cacggcaagg cgtggaggag gccttttccc      660

tgctggtcca tgagatccag agggtccagg aggccatggc gaaggagccc atggcaaggt      720

cctgtaggga gaagacccgg caccagaagg ccacctgcca ctgtggctgc tctgtggcct      780

gaaggtcttg gccaagaaat gtagaccttt ccccaggcca gggtga                     826


<210>  110
<211>  7979
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse tetracycline transactivator (M2rtTA) - vector

<400>  110
cgataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt       60

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc      120

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga      180

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc      240

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct      300

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg      360

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct      420

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc      480

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg      540

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcatcgata      600

ccgtcgacct cgagacctag aaaaacatgg agcaatcaca agtagcaata cagcagctac      660

caatgctgat tgtgcctggc tagaagcaca agaggaggag gaggtgggtt ttccagtcac      720

acctcaggta cctttaagac caatgactta caaggcagct gtagatctta gccacttttt      780

aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atatccttga      840

tctgtggatc taccacacac aaggctactt ccctgattgg cagaactaca caccagggcc      900

agggatcaga tatccactga cctttggatg gtgctacaag ctagtaccag ttgagcaaga      960

gaaggtagaa gaagccaatg aaggagagaa cacccgcttg ttacaccctg tgagcctgca     1020

tgggatggat gacccggaga gagaagtatt agagtggagg tttgacagcc gcctagcatt     1080

tcatcacatg gcccgagagc tgcatccgga ctgtactggg tctctctggt tagaccagat     1140

ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt     1200

gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc     1260

cctcagaccc ttttagtcag tgtggaaaat ctctagcagg gcccgtttaa acccgctgat     1320

cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     1380

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     1440

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     1500

gggaggattg ggaagacaat agcaggcatg tgagcaaaag gccagcaaaa ggccaggaac     1560

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     1620

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     1680

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     1740

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     1800

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     1860

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     1920

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     1980

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     2040

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     2100

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     2160

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     2220

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     2280

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     2340

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     2400

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     2460

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     2520

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     2580

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     2640

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     2700

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     2760

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     2820

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     2880

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     2940

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     3000

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     3060

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     3120

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     3180

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     3240

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     3300

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tcgacggatc gggagatctc     3360

ccgatcccct atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagt     3420

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta     3480

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg     3540

cgctgcttcg cgatgtacgg gccagatata cgcgttgaca ttgattattg actagttatt     3600

aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat     3660

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa     3720

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg     3780

agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc     3840

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct     3900

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga     3960

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa     4020

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc     4080

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg     4140

aggtctatat aagcagcgcg ttttgcctgt actgggtctc tctggttaga ccagatctga     4200

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct     4260

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc     4320

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaaag     4380

cgaaagggaa accagaggag ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg     4440

caagaggcga ggggcggcga ctggtgagta cgccaaaaat tttgactagc ggaggctaga     4500

aggagagaga tgggtgcgag agcgtcagta ttaagcgggg gagaattaga tcgcgatggg     4560

aaaaaattcg gttaaggcca gggggaaaga aaaaatataa attaaaacat atagtatggg     4620

caagcaggga gctagaacga ttcgcagtta atcctggcct gttagaaaca tcagaaggct     4680

gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat     4740

cattatataa tacagtagca accctctatt gtgtgcatca aaggatagag ataaaagaca     4800

ccaaggaagc tttagacaag atagaggaag agcaaaacaa aagtaagacc accgcacagc     4860

aagcggccgc tgatcttcag acctggagga ggagatatga gggacaattg gagaagtgaa     4920

ttatataaat ataaagtagt aaaaattgaa ccattaggag tagcacccac caaggcaaag     4980

agaagagtgg tgcagagaga aaaaagagca gtgggaatag gagctttgtt ccttgggttc     5040

ttgggagcag caggaagcac tatgggcgca gcgtcaatga cgctgacggt acaggccaga     5100

caattattgt ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgcaa     5160

cagcatctgt tgcaactcac agtctggggc atcaagcagc tccaggcaag aatcctggct     5220

gtggaaagat acctaaagga tcaacagctc ctggggattt ggggttgctc tggaaaactc     5280

atttgcacca ctgctgtgcc ttggaatgct agttggagta ataaatctct ggaacagatt     5340

tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac aagcttaata     5400

cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga attattggaa     5460

ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct gtggtatata     5520

aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt tgctgtactt     5580

tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac ccacctccca     5640

accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga gagagacaga     5700

gacagatcca ttcgattagt gaacggatcg gcactgcgtg cgccaattct gcagacaaat     5760

ggcagtattc atccacaatt ttaaaagaaa aggggggatt ggggggtaca gtgcagggga     5820

aagaatagta gacataatag caacagacat acaaactaaa gaattacaaa aacaaattac     5880

aaaaattcaa aattttcggg tttattacag ggacagcaga gatccagttt ggttaattaa     5940

cccgtgtcgg ctccagatct ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc     6000

cctcctcacg gcgagcgctg ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc     6060

cgcccggacg ctcaggacag cggcccgctg ctcataagac tcggccttag aaccccagta     6120

tcagcagaag gacattttag gacgggactt gggtgactct agggcactgg ttttctttcc     6180

agagagcgga acaggcgagg aaaagtagtc ccttctcggc gattctgcgg agggatctcc     6240

gtggggcggt gaacgccgat gattatataa ggacgcgccg ggtgtggcac agctagttcc     6300

gtcgcagccg ggatttgggt cgcggttctt gtttgtggat cgctgtgatc gtcacttggt     6360

gagtagcggg ctgctgggct ggccggggct ttcgtggccg ccgggccgct cggtgggacg     6420

gaagcgtgtg gagagaccgc caagggctgt agtctgggtc cgcgagcaag gttgccctga     6480

actgggggtt ggggggagcg cagcaaaatg gcggctgttc ccgagtcttg aatggaagac     6540

gcttgtgagg cgggctgtga ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga     6600

acccaaggtc ttgaggcctt cgctaatgcg ggaaagctct tattcgggtg agatgggctg     6660

gggcaccatc tggggaccct gacgtgaagt ttgtcactga ctggagaact cggtttgtcg     6720

tctgttgcgg gggcggcagt tatggcggtg ccgttgggca gtgcacccgt acctttggga     6780

gcgcgcgccc tcgtcgtgtc gtgacgtcac ccgttctgtt ggcttataat gcagggtggg     6840

gccacctgcc ggtaggtgtg cggtaggctt ttctccgtcg caggacgcag ggttcgggcc     6900

tagggtaggc tctcctgaat cgacaggcgc cggacctctg gtgaggggag ggataagtga     6960

ggcgtcagtt tctttggtcg gttttatgta cctatcttct taagtagctg aagctccggt     7020

tttgaactat gcgctcgggg ttggcgagtg tgttttgtga agttttttag gcaccttttg     7080

aaatgtaatc atttgggtca atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta     7140

aattctggcc gtttttggct tttttgttag acgaagcttg ggcccgggaa ttaattcacc     7200

atgtctagac tggacaagag caaagtcata aacggcgctc tggaattact caatggagtc     7260

ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc tgggagttga gcagcctacc     7320

ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg ccctgccaat cgagatgctg     7380

gacaggcatc atacccactt ctgccccctg gaaggcgagt catggcaaga ctttctgcgg     7440

aacaacgcca agtcattccg ctgtgctctc ctctcacatc gcgacggggc taaagtgcat     7500

ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg aaaatcagct cgcgttcctg     7560

tgtcagcaag gcttctccct ggagaacgca ctgtacgctc tgtccgccgt gggccacttt     7620

acactgggct gcgtattgga ggaacaggag catcaagtag caaaagagga aagagagaca     7680

cctaccaccg attctatgcc cccacttctg agacaagcaa ttgagctgtt cgaccggcag     7740

ggagccgaac ctgccttcct tttcggcctg gaactaatca tatgtggcct ggagaaacag     7800

ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg attttgactt agacatgctc     7860

ccagccgatg cccttgacga ctttgacctt gatatgctgc ctgctgacgc tcttgacgat     7920

tttgaccttg acatgctccc cgggtaacta agtaaggatc aattcgatat caagcttat      7979


<210>  111
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  111
aatattagag tctcaacccc caataaatat aggactggag atgtctgagg ctcattctgc       60

cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc ccagctatga      120

actccttctc cacaagcgcc ttcggtccag ttgccttctc cctggggctg ctcctggtgt      180

tgcctgctgc cttccctgcc ccagtacccc caggagaaga ttccaaagat gtagccgccc      240

cacacagaca gccactcacc tcttcagaac gaattgacaa acaaattcgg tacatcctcg      300

acggcatctc agccctgaga aaggagacat gtaacaagag taacatgtgt gaaagcagca      360

aagaggcact ggcagaaaac aacctgaacc ttccaaagat ggctgaaaaa gatggatgct      420

tccaatctgg attcaatgag gagacttgcc tggtgaaaat catcactggt cttttggagt      480

ttgaggtata cctagagtac ctccagaaca gatttgagag tagtgaggaa caagccagag      540

ctgtgcagat gagtacaaaa gtcctgatcc agttcctgca gaaaaaggca aagaatctag      600

atgcaataac cacccctgac ccaaccacaa atgccagcct gctgacgaag ctgcaggcac      660

agaaccagtg gctgcaggac atgacaactc atctcattct gcgcagcttt aaggagttcc      720

tgcagtccag cctgagggct cttcggcaaa tgtagcatgg gcacctcaga ttgttgttgt      780

taatgggcat tccttcttct ggtcagaaac ctgtccactg ggcacagaac ttatgttgtt      840

ctctatggag aactaaaagt atgagcgtta ggacactatt ttaattattt ttaatttatt      900

aatatttaaa tatgtgaagc tgagttaatt tatgtaagtc atatttatat ttttaagaag      960

taccacttga aacattttat gtattagttt tgaaataata atggaaagtg gctatgcagt     1020

ttgaatatcc tttgtttcag agccagatca tttcttggaa agtgtaggct tacctcaaat     1080

aaatggctaa cttatacata tttttaaaga aatatttata ttgtatttat ataatgtata     1140

aatggttttt ataccaataa atggcatttt aaaaaattca gcaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210>  112
<211>  1902
<212>  DNA
<213>  Homo sapiens

<400>  112
atgaccgaag aagcatgccg aacacggagt cagaaacgag cgcttgaacg ggacccaaca       60

gaggacgatg tggagagcaa gaaaataaaa atggagagag gattgttggc ttcagattta      120

aacactgacg gagacatgag ggtgacacct gagccgggag caggtccaac ccaaggattg      180

ctgagggcaa cagaggccac ggccatggcc atgggcagag gcgaagggct ggtgggcgat      240

gggcccgtgg acatgcgcac ctcacacagt gacatgaagt ccgagaggag acccccctca      300

cctgacgtga ttgtgctctc cgacaacgag cagccctcga gcccgagagt gaatgggctg      360

accacggtgg ccttgaagga gactagcacc gaggccctca tgaaaagcag tcctgaagaa      420

cgagaaagga tgatcaagca gctgaaggaa gaattgaggt tagaagaagc aaaactcgtg      480

ttgttgaaaa agttgcggca gagtcaaata caaaaggaag ccaccgccca gaagcccaca      540

ggttctgttg ggagcaccgt gaccacccct cccccgcttg ttcggggcac tcagaacatt      600

cctgctggca agccatcact ccagacctct tcagctcgga tgcccggcag tgtcataccc      660

ccgcccctgg tccgaggtgg gcagcaggcg tcctcgaagc tggggccaca ggcgagctca      720

caggtcgtca tgcccccact cgtcaggggg gctcagcaaa tccacagcat taggcaacat      780

tccagcacag ggccaccgcc cctcctcctg gccccccggg cgtcggtgcc cagtgtgcag      840

attcagggac agaggatcat ccagcagggc ctcatccgcg tcgccaatgt tcccaacacc      900

agcctgctcg tcaacatccc acagcccacc ccagcatcac tgaaggggac aacagccacc      960

tccgctcagg ccaactccac ccccactagt gtggcctctg tggtcacctc tgccgagtct     1020

ccagcaagcc gacaggcggc cgccaagctg gcgctgcgca aacagctgga gaagacgcta     1080

ctcgagatcc ccccacccaa gcccccagcc ccagagatga acttcctgcc cagcgccgcc     1140

aacaacgagt tcatctacct ggtcggcctg gaggaggtgg tgcagaacct actggagaca     1200

caaggcagga tgtcggccgc cactgtgctg tcccgggagc cctacatgtg tgcacagtgc     1260

aagacggact tcacgtgccg ctggcgggag gagaagagcg gcgccatcat gtgtgagaac     1320

tgcatgacaa ccaaccagaa gaaggcgctc aaggtggagc acaccagccg gctgaaggcc     1380

gcctttgtga aggcgctgca gcaggaacag gagattgagc agcggctcct gcagcagggc     1440

acggcccctg cacaggccaa ggccgagccc accgctgccc cacaccccgt gctgaagcag     1500

gtcataaaac cccggcgtaa gttggcgttc cgctcaggag aggcccgcga ctggagtaac     1560

ggggctgtgc tacaggcctc cagccagctg tcccggggtt cggccacgac gccccgaggt     1620

gtcctgcaca cgttcagtcc gtcacccaaa ctgcagaact cagcctcggc cacagccctg     1680

gtcagcagga ccggcagaca ttctgagaga accgtgagcg ccggcaaggg cagcgccacc     1740

tccaactgga agaagacgcc cctcagcaca ggcgggaccc ttgcgtttgt cagcccaagc     1800

ctggcggtgc acaagagctc ctcggccgtg gaccgccagc gagagtacct cctggacatg     1860

atcccacccc gctccatccc ccagtcagcc acgtggaaat ag                        1902


<210>  113
<211>  123
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(123)
<223>  P66 alpha coiled-coil domain coding sequence

<400>  113
cctgaagaac gagaaaggat gatcaagcag ctgaaggaag aattgaggtt agaagaagca       60

aaactcgtgt tgttgaaaaa gttgcggcag agtcaaatac aaaaggaagc caccgcccag      120

aag                                                                    123


<210>  114
<211>  41
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(41)
<223>  P66 alpha coiled-coil domain

<400>  114

Pro Glu Glu Arg Glu Arg Met Ile Lys Gln Leu Lys Glu Glu Leu Arg 
1               5                   10                  15      


Leu Glu Glu Ala Lys Leu Val Leu Leu Lys Lys Leu Arg Gln Ser Gln 
            20                  25                  30          


Ile Gln Lys Glu Ala Thr Ala Gln Lys 
        35                  40      


<210>  115
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  115
aaaaaaaccg gtcctgaaga acgagaaagg                                        30


<210>  116
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  116
aaaaaactta agcttctggg cggtggc                                           27


<210>  117
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  118
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
1               5                   10                  15      


Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
            20                  25                  30          


Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
        35                  40                  45              


His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
    50                  55                  60                  


Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                85                  90                  95      


Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
        115                 120                 125             


Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
    130                 135                 140                 


Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
145                 150                 155                 160 


Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                165                 170                 175     


Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
            180                 185                 190         


Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
        195                 200                 205             


Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
    210                 215                 220                 


Ile Ser Glu Cys Lys Cys Ser Cys 
225                 230         


<210>  119
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Lys Val Leu Ala Ala Val His Ser Pro Gly Gly Ala Val Pro Gln 
1               5                   10                  15      


Gln Pro Gly Gln Ala Met Trp Pro Gln Arg Asp Gly Leu Pro Ala Leu 
            20                  25                  30          


Pro Arg Gln Arg His Gly Glu Gly Gln Ala Gly Gly Ala Val Pro His 
        35                  40                  45              


Ser Arg Val Pro Trp His Leu Pro Gly Gln His His Pro Gly Pro Glu 
    50                  55                  60                  


Asp Pro Gln Pro Gln Cys Pro Gln Pro Pro Gln Gln Ala Gln Arg His 
65                  70                  75                  80  


Arg Arg His Pro Ala Arg Pro Pro 
                85              


<210>  120
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  121
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp 
    290                 295                 300                 


Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro 
305                 310                 315                 320 


Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr 
                325                 330                 335     


Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe 
            340                 345                 350         


Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp 
        355                 360                 365             


Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro 
    370                 375                 380                 


Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala 
385                 390                 395                 400 


Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly 
                405                 410                 415     


Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser 
            420                 425                 430         


Thr 
    


<210>  122
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  123
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  123
agtacagtat aaaacttcac agtgccaata ccatgaagag gagctcagac agctcttacc       60

acatgataca agagccggct ggtggaagag tggggaccag aaagagaatt tgctgaagag      120

gagaaggaaa aaaaaaacac caaaaaaaaa aataaaaaaa tccacacaca caaaaaaacc      180

tgcgcgtgag gggggaggaa aagcagggcc ttttaaaaag gcaatcacaa caacttttgc      240

tgccaggatg cccttgcttt ggctgagagg atttctgttg gcaagttgct ggattatagt      300

gaggagttcc cccaccccag gatccgaggg gcacagcgcg gcccccgact gtccgtcctg      360

tgcgctggcc gccctcccaa aggatgtacc caactctcag ccagagatgg tggaggccgt      420

caagaagcac attttaaaca tgctgcactt gaagaagaga cccgatgtca cccagccggt      480

acccaaggcg gcgcttctga acgcgatcag aaagcttcat gtgggcaaag tcggggagaa      540

cgggtatgtg gagatagagg atgacattgg aaggagggca gaaatgaatg aacttatgga      600

gcagacctcg gagatcatca cgtttgccga gtcaggaaca gccaggaaga cgctgcactt      660

cgagatttcc aaggaaggca gtgacctgtc agtggtggag cgtgcagaag tctggctctt      720

cctaaaagtc cccaaggcca acaggaccag gaccaaagtc accatccgcc tcttccagca      780

gcagaagcac ccgcagggca gcttggacac aggggaagag gccgaggaag tgggcttaaa      840

gggggagagg agtgaactgt tgctctctga aaaagtagta gacgctcgga agagcacctg      900

gcatgtcttc cctgtctcca gcagcatcca gcggttgctg gaccagggca agagctccct      960

ggacgttcgg attgcctgtg agcagtgcca ggagagtggc gccagcttgg ttctcctggg     1020

caagaagaag aagaaagaag aggaggggga agggaaaaag aagggcggag gtgaaggtgg     1080

ggcaggagca gatgaggaaa aggagcagtc gcacagacct ttcctcatgc tgcaggcccg     1140

gcagtctgaa gaccaccctc atcgccggcg tcggcggggc ttggagtgtg atggcaaggt     1200

caacatctgc tgtaagaaac agttctttgt cagtttcaag gacatcggct ggaatgactg     1260

gatcattgct ccctctggct atcatgccaa ctactgcgag ggtgagtgcc cgagccatat     1320

agcaggcacg tccgggtcct cactgtcctt ccactcaaca gtcatcaacc actaccgcat     1380

gcggggccat agcccctttg ccaacctcaa atcgtgctgt gtgcccacca agctgagacc     1440

catgtccatg ttgtactatg atgatggtca aaacatcatc aaaaaggaca ttcagaacat     1500

gatcgtggag gagtgtgggt gctcatagag ttgcccagcc cagggggaaa gggagcaaga     1560

gttgtccaga gaagacagtg gcaaaatgaa gaaattttta aggtttctga gttaaccaga     1620

aaaatagaaa ttaaaaacaa aacaaaaaaa aaaacaaaaa aaaacaaaag taaattaaaa     1680

acaaaacctg atgaaacaga tgaaggaaga tgtggaaaaa atccttagcc agggctcaga     1740

gatgaagcag tgaaagagac aggaattggg agggaaaggg agaatggtgt accctttatt     1800

tcttctgaaa tcacactgat gacatcagtt gtttaaacgg ggtattgtcc tttcccccct     1860

tgaggttccc ttgtgagcct tgaatcaacc aatctagtct gcagtagtgt ggactagaac     1920

aacccaaata gcatctagaa agccatgagt ttgaaagggc ccatcacagg cactttccta     1980

cccaattacc caggtcataa ggtatgtctg tgtgacactt atctctgtgt atatcagcat     2040

acacacacac acacacacac acacacacac acacaggcat ttccacacat tacatatata     2100

cacatactgg taaaagaaca atcgtgtgca ggtggtcaca cttccttttt ctgtaccact     2160

tttgcaacaa aacaa                                                      2175


<210>  124
<211>  3029
<212>  DNA
<213>  Homo sapiens

<400>  124
ccgcagagag gtgtggtcag ggacatttcc cctggccggg agcccatgga gcactgtcct       60

cagagatgcg caggttaggc tcactgtcta ggccaggccc accttagtca ctgtggactg      120

gcaatggaag ctcttcctgg acacacctgc cctagccctc accctggggt ggaagagaaa      180

tgagcttggc ttgcaactca gaccattcca cggaggcatc ctccccttcc tgggctggtg      240

aataaaagtt tcctgaggtc aaggacttcc ttttccctgc caaaatggtg tccagaactt      300

tgaggccaga ggtgatccag tgatttggga gctgcaggtc acacaggctg ctcagagggc      360

tgctgaacag gatgtcctcg gacgacaggc acctgggctc cagctgcggc tccttcatca      420

agactgagcc gtccagcccg tcctcgggca tcgatgccct cagccaccac agccccagtg      480

gctcgtccga cgccagcggc ggctttggcc tggccctggg cacccacgcc aacggtctgg      540

actcgccacc catgtttgca ggcgccgggc tgggaggcac cccatgccgc aagagctacg      600

aggactgtgc cagcggcatc atggaggact cggccatcaa gtgcgagtac atgctcaacg      660

ccatccccaa gcgcctgtgc ctcgtgtgcg gggacattgc ctctggctac cactacggcg      720

tggcctcctg cgaggcttgc aaggccttct tcaagaggac tatccaaggg aacattgagt      780

acagctgccc ggccaccaac gagtgcgaga tcaccaaacg gaggcgcaag tcctgccagg      840

cctgccgctt catgaaatgc ctcaaagtgg ggatgctgaa ggaaggtgtg cgccttgatc      900

gagtgcgtgg aggccgtcag aaatacaagc gacggctgga ctcagagagc agcccatacc      960

tgagcttaca aatttctcca cctgctaaaa agccattgac caagattgtc tcatacctac     1020

tggtggctga gccggacaag ctctatgcca tgcctccccc tggtatgcct gagggggaca     1080

tcaaggccct gaccactctc tgtgacctgg cagaccgaga gcttgtggtc atcattggct     1140

gggccaagca catcccaggc ttctcaagcc tctccctggg ggaccagatg agcctgctgc     1200

agagtgcctg gatggaaatc ctcatcctgg gcatcgtgta ccgctcgctg ccctatgacg     1260

acaagctggt gtacgctgag gactacatca tggatgagga gcactcccgc ctcgcggggc     1320

tgctggagct ctaccgggcc atcctgcagc tggtacgcag gtacaagaag ctcaaggtgg     1380

agaaggagga gtttgtgacg ctcaaggccc tggccctcgc caactccgat tccatgtaca     1440

tcgaggatct agaggctgtc cagaagctgc aggacctgct gcacgaggca ctgcaggact     1500

acgagctgag ccagcgccat gaggagccct ggaggacggg caagctgctg ctgacactgc     1560

cgctgctgcg gcagacggcc gccaaggccg tgcagcactt ctatagcgtc aaactgcagg     1620

gcaaagtgcc catgcacaaa ctcttcctgg agatgctgga ggccaaggtt ggccaagagc     1680

agcttagagg atctcccaag gatgaaagaa tgtcaagcca tgatggaaaa tgccccttcc     1740

aatcagctgc cttcacaagc agggatcaga gcaactcccc ggggatcccc aatccacgcc     1800

cttctagtcc aacccccctc aatgagagag gcaggcagat ctcacccagc actaggacac     1860

caggaggcca gggaaagcat ctctggctca ccatgtaaca tctggcttgg agcaagtggg     1920

tgttctgcac accaggcagc tgcacctcac tggatctagt gttgctgcga gtgacctcac     1980

ttcagagccc ctctagcaga gtggggcgga agtcctgatg gttggtgtcc atgaggtgga     2040

agctgctttt atacttaaaa ctcagatcac aacaggaaat gtgtcagtaa caatggaact     2100

ccatccaatg ggaaagttcc tggtactgaa ggggtccatt ggacactcag aaaagaagtt     2160

caggggccaa cttcttagct ggaatcctgg ccagatgagg accctctccg gggaagggag     2220

aggactgact tagtggaagg tggtgaagtg aggagagttt aggggaacct tcccccagtg     2280

gaacagatct caagtttacc ctaaacctgc catttctgga aaatctgtaa agaggaaaca     2340

gcctgtctca gctgtactct catgatacag gtcatttgaa atgaaccaag aaataaaaca     2400

tgaaaatcca accatggaga aggtggtatg gctgggtttt gtttggtccc cttgtcctta     2460

tacgttctaa agtttccaga ctggctttgt cactttgtga actcgtcatg tgtgaaaacc     2520

aatctttgca tatagggaac ttcctcgggc cacactttaa gaaccaagta agaggctctc     2580

aagactccag cagagtcggg aggccatggc agcgccttag aggagctgga acctgcaccc     2640

acctgtgtcg gtgggggggg cctcctttcc ccatagactc tgccctccct ctgtgcagat     2700

ggaagtggca ggggagggtg accagcttgt gacaagaaga ctgaagggtc cagagtccat     2760

gctcacggaa cagcaccaaa gaaaagcact atgtggaaag attgttttat tttctaataa     2820

tgataatatg gctggaatgg cttcttaaga tgtatatatt ttttaaaatg gcagttcccc     2880

attgcagcat cacctacttg tatgtctttc tgcctctgta tatgttctcc cagaaacccc     2940

catgtaaatc aaatgcccta ggatgcttcc atcctggtcc catgtatctg gaatctaata     3000

aataaggaaa ggaaaaaaaa aaaaaaaaa                                       3029


<210>  125
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ser Ser Asp Asp Arg His Leu Gly Ser Ser Cys Gly Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ser Ser Gly Ile Asp Ala Leu Ser His 
            20                  25                  30          


His Ser Pro Ser Gly Ser Ser Asp Ala Ser Gly Gly Phe Gly Leu Ala 
        35                  40                  45              


Leu Gly Thr His Ala Asn Gly Leu Asp Ser Pro Pro Met Phe Ala Gly 
    50                  55                  60                  


Ala Gly Leu Gly Gly Thr Pro Cys Arg Lys Ser Tyr Glu Asp Cys Ala 
65                  70                  75                  80  


Ser Gly Ile Met Glu Asp Ser Ala Ile Lys Cys Glu Tyr Met Leu Asn 
                85                  90                  95      


Ala Ile Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala Ser Gly 
            100                 105                 110         


Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe Phe Lys 
        115                 120                 125             


Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr Asn Glu 
    130                 135                 140                 


Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys Arg Phe 
145                 150                 155                 160 


Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg Leu Asp 
                165                 170                 175     


Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Leu Asp Ser Glu 
            180                 185                 190         


Ser Ser Pro Tyr Leu Ser Leu Gln Ile Ser Pro Pro Ala Lys Lys Pro 
        195                 200                 205             


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
    210                 215                 220                 


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
225                 230                 235                 240 


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
                245                 250                 255     


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
            260                 265                 270         


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
        275                 280                 285             


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
    290                 295                 300                 


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
305                 310                 315                 320 


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
                325                 330                 335     


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
            340                 345                 350         


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
        355                 360                 365             


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
    370                 375                 380                 


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
385                 390                 395                 400 


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
                405                 410                 415     


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
            420                 425                 430         


Val Gly Gln Glu Gln Leu Arg Gly Ser Pro Lys Asp Glu Arg Met Ser 
        435                 440                 445             


Ser His Asp Gly Lys Cys Pro Phe Gln Ser Ala Ala Phe Thr Ser Arg 
    450                 455                 460                 


Asp Gln Ser Asn Ser Pro Gly Ile Pro Asn Pro Arg Pro Ser Ser Pro 
465                 470                 475                 480 


Thr Pro Leu Asn Glu Arg Gly Arg Gln Ile Ser Pro Ser Thr Arg Thr 
                485                 490                 495     


Pro Gly Gly Gln Gly Lys His Leu Trp Leu Thr Met 
            500                 505             


<210>  126
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Leu Ser Glu Pro Ile Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Pro Cys Arg Glu Arg Gly Leu Gln Glu Arg Trp Pro Arg Ala Glu Pro 
            20                  25                  30          


Glu Ser Gly Gly Thr Asp Asp Asp Leu Asn Ser Val Leu Asp Phe Ile 
        35                  40                  45              


Leu Ser Met Gly Leu Asp Gly Leu Gly Ala Glu Ala Ala Pro Glu Pro 
    50                  55                  60                  


Pro Pro Pro Pro Pro Pro Pro Ala Phe Tyr Tyr Pro Glu Pro Gly Ala 
65                  70                  75                  80  


Pro Pro Pro Tyr Ser Ala Pro Ala Gly Gly Leu Val Ser Glu Leu Leu 
                85                  90                  95      


Arg Pro Glu Leu Asp Ala Pro Leu Gly Pro Ala Leu His Gly Arg Phe 
            100                 105                 110         


Leu Leu Ala Pro Pro Gly Arg Leu Val Lys Ala Glu Pro Pro Glu Ala 
        115                 120                 125             


Asp Gly Gly Gly Gly Tyr Gly Cys Ala Pro Gly Leu Thr Arg Gly Pro 
    130                 135                 140                 


Arg Gly Leu Lys Arg Glu Gly Ala Pro Gly Pro Ala Ala Ser Cys Met 
145                 150                 155                 160 


Arg Gly Pro Gly Gly Arg Pro Pro Pro Pro Pro Asp Thr Pro Pro Leu 
                165                 170                 175     


Ser Pro Asp Gly Pro Ala Arg Leu Pro Ala Pro Gly Pro Arg Ala Ser 
            180                 185                 190         


Phe Pro Pro Pro Phe Gly Gly Pro Gly Phe Gly Ala Pro Gly Pro Gly 
        195                 200                 205             


Leu His Tyr Ala Pro Pro Ala Pro Pro Ala Phe Gly Leu Phe Asp Asp 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Leu Gly Leu Ala Pro Pro Ala Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Thr Pro Pro Ala Ser Pro Leu Glu Leu Leu Glu Ala Lys 
                245                 250                 255     


Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His 
            260                 265                 270         


Thr Cys Ser Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His 
        275                 280                 285             


Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys 
    290                 295                 300                 


Asn Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr 
305                 310                 315                 320 


Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys His Leu 
                325                 330                 335     


Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys 
            340                 345                 350         


Arg His Met 
        355 


<210>  127
<211>  1655
<212>  DNA
<213>  Homo sapiens

<400>  127
gcccgcccgc gccccgacca gcccggcctc gggcagccac tcaccggtgt ccccgtccgc       60

gtccttcctc cccgggtccc ggccatggcg ctgagtgaac ccatcctgcc gtccttctcc      120

actttcgcca gcccgtgccg cgagcgcggc ctgcaggagc gctggccgcg cgccgaaccc      180

gagtccggcg gcaccgacga cgacctcaac agcgtgctgg acttcatcct gtccatgggg      240

ctggatggcc tgggcgccga ggccgccccg gagccgccgc cgccgccccc gccgcctgcg      300

ttctattacc ccgaacccgg cgcgcccccg ccctacagcg cccccgcggg tggcctggtg      360

tctgagctgc tgcgacccga gctggatgcg ccgctggggc ccgcactgca cggccgcttt      420

ctgctggcgc cgcccggccg cctggtcaag gccgagcccc ctgaagcgga cggcggcggc      480

ggctacggct gcgcccccgg gctgacccgt ggaccgcgcg gcctcaagcg cgagggcgcc      540

ccgggcccgg cggcttcgtg catgcgaggt cccgggggcc gccccccgcc gccgcccgac      600

acaccgccgc tcagccccga cggccccgcg cgcctgcccg cgcccggtcc gcgcgcctcc      660

ttcccgccgc ctttcggtgg ccctggtttc ggcgcgcccg ggcccggcct gcattacgcg      720

ccgcctgcgc ccccagcctt cggtctcttc gacgacgcgg ccgccgccgc ggcagccctg      780

ggcctggcgc cccccgccgc ccgcggtctc ctcacgccgc ctgcgtcccc gctggagctg      840

ctggaggcca agccaaagcg cggccgccgc tcttggcccc gcaaacgcac cgccactcac      900

acctgcagct acgcgggctg cggcaagacc tacaccaaga gttcgcatct gaaggcgcat      960

ctgcgcacgc acacaggtga gaagccctac cactgcaact gggacggctg cggctggaag     1020

tttgcgcgct cagacgagct cacgcgccac taccgaaagc acacgggcca ccggccattc     1080

cagtgccatc tgtgcgatcg tgccttctcg cgctccgatc acctggcgct gcacatgaaa     1140

cggcacatgt agccgggacg cccccgccca cctgcgcgcg gccgtggcgg gtcccacgcg     1200

ccgggcgcgg ccccctccca aactgtgact ggtatttatt ggacccagag aaccgggccg     1260

ggcacagcgt ggctacagag ggtctccctc gatgacgacg acgacgacgc caccacccca     1320

gcccccgtct gtgactgaag gcccggtggg aaaagaccac gatcctcctt gacgagtttt     1380

gtttttcaaa atggtgcaat aatttaagtg gcatcttctc tcccaccggg tctacactag     1440

aggatcgagg cttgtgatgc cttgtgagaa ataagggcct taatttgtac tgtctgcggc     1500

attttttata atattgtata tagtgactga caaatattgt attactgtac atagagagac     1560

aggtgggcat ttttgggcta cctggttcgt ttttataaga ttttgctggg ttggtttttt     1620

ttttaattaa aaagttttgc atcttttaaa aaaaa                                1655


<210>  128
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ser Leu Ser Met Arg Asp Pro Val Ile Pro Gly Thr Ser Met Ala 
1               5                   10                  15      


Tyr His Pro Phe Leu Pro His Arg Ala Pro Asp Phe Ala Met Ser Ala 
            20                  25                  30          


Val Leu Gly His Gln Pro Pro Phe Phe Pro Ala Leu Thr Leu Pro Pro 
        35                  40                  45              


Asn Gly Ala Ala Ala Leu Ser Leu Pro Gly Ala Leu Ala Lys Pro Ile 
    50                  55                  60                  


Met Asp Gln Leu Val Gly Ala Ala Glu Thr Gly Ile Pro Phe Ser Ser 
65                  70                  75                  80  


Leu Gly Pro Gln Ala His Leu Arg Pro Leu Lys Thr Met Glu Pro Glu 
                85                  90                  95      


Glu Glu Val Glu Asp Asp Pro Lys Val His Leu Glu Ala Lys Glu Leu 
            100                 105                 110         


Trp Asp Gln Phe His Lys Arg Gly Thr Glu Met Val Ile Thr Lys Ser 
        115                 120                 125             


Gly Arg Arg Met Phe Pro Pro Phe Lys Val Arg Cys Ser Gly Leu Asp 
    130                 135                 140                 


Lys Lys Ala Lys Tyr Ile Leu Leu Met Asp Ile Ile Ala Ala Asp Asp 
145                 150                 155                 160 


Cys Arg Tyr Lys Phe His Asn Ser Arg Trp Met Val Ala Gly Lys Ala 
                165                 170                 175     


Asp Pro Glu Met Pro Lys Arg Met Tyr Ile His Pro Asp Ser Pro Ala 
            180                 185                 190         


Thr Gly Glu Gln Trp Met Ser Lys Val Val Thr Phe His Lys Leu Lys 
        195                 200                 205             


Leu Thr Asn Asn Ile Ser Asp Lys His Gly Phe Thr Ile Leu Asn Ser 
    210                 215                 220                 


Met His Lys Tyr Gln Pro Arg Phe His Ile Val Arg Ala Asn Asp Ile 
225                 230                 235                 240 


Leu Lys Leu Pro Tyr Ser Thr Phe Arg Thr Tyr Leu Phe Pro Glu Thr 
                245                 250                 255     


Glu Phe Ile Ala Val Thr Ala Tyr Gln Asn Asp Lys Ile Thr Gln Leu 
            260                 265                 270         


Lys Ile Asp Asn Asn Pro Phe Ala Lys Gly Phe Arg Asp Thr Gly Asn 
        275                 280                 285             


Gly Arg Arg Glu Lys Arg Lys Gln Leu Thr Leu Gln Ser Met Arg Val 
    290                 295                 300                 


Phe Asp Glu Arg His Lys Lys Glu Asn Gly Thr Ser Asp Glu Ser Ser 
305                 310                 315                 320 


Ser Glu Gln Ala Ala Phe Asn Cys Phe Ala Gln Ala Ser Ser Pro Ala 
                325                 330                 335     


Ala Ser Thr Val Gly Thr Ser Asn Leu Lys Asp Leu Cys Pro Ser Glu 
            340                 345                 350         


Gly Glu Ser Asp Ala Glu Ala Glu Ser Lys Glu Glu His Gly Pro Glu 
        355                 360                 365             


Ala Cys Asp Ala Ala Lys Ile Ser Thr Thr Thr Ser Glu Glu Pro Cys 
    370                 375                 380                 


Arg Asp Lys Gly Ser Pro Ala Val Lys Ala His Leu Phe Ala Ala Glu 
385                 390                 395                 400 


Arg Pro Arg Asp Ser Gly Arg Leu Asp Lys Ala Ser Pro Asp Ser Arg 
                405                 410                 415     


His Ser Pro Ala Thr Ile Ser Ser Ser Thr Arg Gly Leu Gly Ala Glu 
            420                 425                 430         


Glu Arg Arg Ser Pro Val Arg Glu Gly Thr Ala Pro Ala Lys Val Glu 
        435                 440                 445             


Glu Ala Arg Ala Leu Pro Gly Lys Glu Ala Phe Ala Pro Leu Thr Val 
    450                 455                 460                 


Gln Thr Asp Ala Ala Ala Ala His Leu Ala Gln Gly Pro Leu Pro Gly 
465                 470                 475                 480 


Leu Gly Phe Ala Pro Gly Leu Ala Gly Gln Gln Phe Phe Asn Gly His 
                485                 490                 495     


Pro Leu Phe Leu His Pro Ser Gln Phe Ala Met Gly Gly Ala Phe Ser 
            500                 505                 510         


Ser Met Ala Ala Ala Gly Met Gly Pro Leu Leu Ala Thr Val Ser Gly 
        515                 520                 525             


Ala Ser Thr Gly Val Ser Gly Leu Asp Ser Thr Ala Met Ala Ser Ala 
    530                 535                 540                 


Ala Ala Ala Gln Gly Leu Ser Gly Ala Ser Ala Ala Thr Leu Pro Phe 
545                 550                 555                 560 


His Leu Gln Gln His Val Leu Ala Ser Gln Gly Leu Ala Met Ser Pro 
                565                 570                 575     


Phe Gly Ser Leu Phe Pro Tyr Pro Tyr Thr Tyr Met Ala Ala Ala Ala 
            580                 585                 590         


Ala Ala Ser Ser Ala Ala Ala Ser Ser Ser Val His Arg His Pro Phe 
        595                 600                 605             


Leu Asn Leu Asn Thr Met Arg Pro Arg Leu Arg Tyr Ser Pro Tyr Ser 
    610                 615                 620                 


Ile Pro Val Pro Val Pro Asp Gly Ser Ser Leu Leu Thr Thr Ala Leu 
625                 630                 635                 640 


Pro Ser Met Ala Ala Ala Ala Gly Pro Leu Asp Gly Lys Val Ala Ala 
                645                 650                 655     


Leu Ala Ala Ser Pro Ala Ser Val Ala Val Asp Ser Gly Ser Glu Leu 
            660                 665                 670         


Asn Ser Arg Ser Ser Thr Leu Ser Ser Ser Ser Met Ser Leu Ser Pro 
        675                 680                 685             


Lys Leu Cys Ala Glu Lys Glu Ala Ala Thr Ser Glu Leu Gln Ser Ile 
    690                 695                 700                 


Gln Arg Leu Val Ser Gly Leu Glu Ala Lys Pro Asp Arg Ser Arg Ser 
705                 710                 715                 720 


Ala Ser Pro 
            


<210>  129
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ser Leu Ser Met Arg Asp Pro Val Ile Pro Gly Thr Ser Met Ala 
1               5                   10                  15      


Tyr His Pro Phe Leu Pro His Arg Ala Pro Asp Phe Ala Met Ser Ala 
            20                  25                  30          


Val Leu Gly His Gln Pro Pro Phe Phe Pro Ala Leu Thr Leu Pro Pro 
        35                  40                  45              


Asn Gly Ala Ala Ala Leu Ser Leu Pro Gly Ala Leu Ala Lys Pro Ile 
    50                  55                  60                  


Met Asp Gln Leu Val Gly Ala Ala Glu Thr Gly Ile Pro Phe Ser Ser 
65                  70                  75                  80  


Leu Gly Pro Gln Ala His Leu Arg Pro Leu Lys Thr Met Glu Pro Glu 
                85                  90                  95      


Glu Glu Val Glu Asp Asp Pro Lys Val His Leu Glu Ala Lys Glu Leu 
            100                 105                 110         


Trp Asp Gln Phe His Lys Arg Gly Thr Glu Met Val Ile Thr Lys Ser 
        115                 120                 125             


Gly Arg Arg Met Phe Pro Pro Phe Lys Val Arg Cys Ser Gly Leu Asp 
    130                 135                 140                 


Lys Lys Ala Lys Tyr Ile Leu Leu Met Asp Ile Ile Ala Ala Asp Asp 
145                 150                 155                 160 


Cys Arg Tyr Lys Phe His Asn Ser Arg Trp Met Val Ala Gly Lys Ala 
                165                 170                 175     


Asp Pro Glu Met Pro Lys Arg Met Tyr Ile His Pro Asp Ser Pro Ala 
            180                 185                 190         


Thr Gly Glu Gln Trp Met Ser Lys Val Val Thr Phe His Lys Leu Lys 
        195                 200                 205             


Leu Thr Asn Asn Ile Ser Asp Lys His Gly Phe Thr Leu Ala Phe Pro 
    210                 215                 220                 


Ser Asp His Ala Thr Trp Gln Gly Asn Tyr Ser Phe Gly Thr Gln Thr 
225                 230                 235                 240 


Ile Leu Asn Ser Met His Lys Tyr Gln Pro Arg Phe His Ile Val Arg 
                245                 250                 255     


Ala Asn Asp Ile Leu Lys Leu Pro Tyr Ser Thr Phe Arg Thr Tyr Leu 
            260                 265                 270         


Phe Pro Glu Thr Glu Phe Ile Ala Val Thr Ala Tyr Gln Asn Asp Lys 
        275                 280                 285             


Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe Ala Lys Gly Phe Arg 
    290                 295                 300                 


Asp Thr Gly Asn Gly Arg Arg Glu Lys Arg Lys Gln Leu Thr Leu Gln 
305                 310                 315                 320 


Ser Met Arg Val Phe Asp Glu Arg His Lys Lys Glu Asn Gly Thr Ser 
                325                 330                 335     


Asp Glu Ser Ser Ser Glu Gln Ala Ala Phe Asn Cys Phe Ala Gln Ala 
            340                 345                 350         


Ser Ser Pro Ala Ala Ser Thr Val Gly Thr Ser Asn Leu Lys Asp Leu 
        355                 360                 365             


Cys Pro Ser Glu Gly Glu Ser Asp Ala Glu Ala Glu Ser Lys Glu Glu 
    370                 375                 380                 


His Gly Pro Glu Ala Cys Asp Ala Ala Lys Ile Ser Thr Thr Thr Ser 
385                 390                 395                 400 


Glu Glu Pro Cys Arg Asp Lys Gly Ser Pro Ala Val Lys Ala His Leu 
                405                 410                 415     


Phe Ala Ala Glu Arg Pro Arg Asp Ser Gly Arg Leu Asp Lys Ala Ser 
            420                 425                 430         


Pro Asp Ser Arg His Ser Pro Ala Thr Ile Ser Ser Ser Thr Arg Gly 
        435                 440                 445             


Leu Gly Ala Glu Glu Arg Arg Ser Pro Val Arg Glu Gly Thr Ala Pro 
    450                 455                 460                 


Ala Lys Val Glu Glu Ala Arg Ala Leu Pro Gly Lys Glu Ala Phe Ala 
465                 470                 475                 480 


Pro Leu Thr Val Gln Thr Asp Ala Ala Ala Ala His Leu Ala Gln Gly 
                485                 490                 495     


Pro Leu Pro Gly Leu Gly Phe Ala Pro Gly Leu Ala Gly Gln Gln Phe 
            500                 505                 510         


Phe Asn Gly His Pro Leu Phe Leu His Pro Ser Gln Phe Ala Met Gly 
        515                 520                 525             


Gly Ala Phe Ser Ser Met Ala Ala Ala Gly Met Gly Pro Leu Leu Ala 
    530                 535                 540                 


Thr Val Ser Gly Ala Ser Thr Gly Val Ser Gly Leu Asp Ser Thr Ala 
545                 550                 555                 560 


Met Ala Ser Ala Ala Ala Ala Gln Gly Leu Ser Gly Ala Ser Ala Ala 
                565                 570                 575     


Thr Leu Pro Phe His Leu Gln Gln His Val Leu Ala Ser Gln Gly Leu 
            580                 585                 590         


Ala Met Ser Pro Phe Gly Ser Leu Phe Pro Tyr Pro Tyr Thr Tyr Met 
        595                 600                 605             


Ala Ala Ala Ala Ala Ala Ser Ser Ala Ala Ala Ser Ser Ser Val His 
    610                 615                 620                 


Arg His Pro Phe Leu Asn Leu Asn Thr Met Arg Pro Arg Leu Arg Tyr 
625                 630                 635                 640 


Ser Pro Tyr Ser Ile Pro Val Pro Val Pro Asp Gly Ser Ser Leu Leu 
                645                 650                 655     


Thr Thr Ala Leu Pro Ser Met Ala Ala Ala Ala Gly Pro Leu Asp Gly 
            660                 665                 670         


Lys Val Ala Ala Leu Ala Ala Ser Pro Ala Ser Val Ala Val Asp Ser 
        675                 680                 685             


Gly Ser Glu Leu Asn Ser Arg Ser Ser Thr Leu Ser Ser Ser Ser Met 
    690                 695                 700                 


Ser Leu Ser Pro Lys Leu Cys Ala Glu Lys Glu Ala Ala Thr Ser Glu 
705                 710                 715                 720 


Leu Gln Ser Ile Gln Arg Leu Val Ser Gly Leu Glu Ala Lys Pro Asp 
                725                 730                 735     


Arg Ser Arg Ser Ala Ser Pro 
            740             


<210>  130
<211>  4754
<212>  DNA
<213>  Homo sapiens

<400>  130
gaattctaga ggcggcggag ggtggcgagg agctctcgct ttctctcgct ccctccctct       60

ccgactccgt ctctctctct ctctctctct ctcccctccc tctctttccc tctgttccat      120

tttttccccc tctaaatcct ccctgccctg cgcgcctgga cacagattta ggaagcgaat      180

tcgctcacgt tttaggacaa ggaagagaga gaggcacggg agaagagccc agcaagattt      240

ggattgaaac cgagacaccc tccggaggct cggagcagag gaaggaggag gagggcggcg      300

aacggaagcc agtttgcaat tcaagttttg atagcgctgg tagaaggggg tttaaatcag      360

attttttttt ttttaaagga gagagacttt ttccgctctc tcgctccctg ttaaagccgg      420

gtctagcaca gctgcagacg ccaccagcga gaaagaggga gaggaagaca gatagggggc      480

gggggaagaa gaaaaagaaa ggtaaaaagt cttctaggag aacctttcac atttgcaaca      540

aaagacctag gggctggaga gagattcctg ggacgcaggg ctggagtgtc tatttcgagc      600

tcagcggcag ggctcgggcg cgagtcgaga ccctgctcgc tcctctcgct tctgaaaccg      660

acgttcagga gcggcttttt aaaaacgcaa ggcacaagga cggtcacccg cgcgactatg      720

tttgctgatt tttcgccttg ccctctttaa aagcggcctc ccattctcca aaagacactt      780

cccctcctcc ctttgaagtg cattagttgt gatttctgcc tccttttctt ttttctttct      840

tttttgtttt gctttttccc cccttttgaa ttatgtgctg ctgttaaaca acaacaaaaa      900

aacaacaaaa cacagcagct gcggacttgt ccccggctgg agcccagcgc cccgcctgga      960

gtggatgagc ctctccatga gagatccggt cattcctggg acaagcatgg cctaccatcc     1020

gttcctacct caccgggcgc cggacttcgc catgagcgcg gtgctgggtc accagccgcc     1080

gttcttcccc gcgctgacgc tgcctcccaa cggcgcggcg gcgctctcgc tgccgggcgc     1140

cctggccaag ccgatcatgg atcaattggt gggggcggcc gagaccggca tcccgttctc     1200

ctccctgggg ccccaggcgc atctgaggcc tttgaagacc atggagcccg aagaagaggt     1260

ggaggacgac cccaaggtgc acctggaggc taaagaactt tgggatcagt ttcacaagcg     1320

gggcaccgag atggtcatta ccaagtcggg aaggcgaatg tttcctccat ttaaagtgag     1380

atgttctggg ctggataaaa aagccaaata cattttattg atggacatta tagctgctga     1440

tgactgtcgt tataaatttc acaattctcg gtggatggtg gctggtaagg ccgaccccga     1500

aatgccaaag aggatgtaca ttcacccgga cagccccgct actggggaac agtggatgtc     1560

caaagtcgtc actttccaca aactgaaact caccaacaac atttcagaca aacatggatt     1620

tactatattg aactccatgc acaaatacca gccccggttc cacattgtaa gagccaatga     1680

catcttgaaa ctcccttata gtacatttcg gacatacttg ttccccgaaa ctgaattcat     1740

cgctgtgact gcataccaga atgataagat aacccagtta aaaatagaca acaacccttt     1800

tgcaaaaggt ttccgggaca ctggaaatgg ccgaagagaa aaaagaaaac agctcaccct     1860

gcagtccatg agggtgtttg atgaaagaca caaaaaggag aatgggacct ctgatgagtc     1920

ctccagtgaa caagcagctt tcaactgctt cgcccaggct tcttctccag ccgcctccac     1980

tgtagggaca tcgaacctca aagatttatg tcccagcgag ggtgagagcg acgccgaggc     2040

cgagagcaaa gaggagcatg gccccgaggc ctgcgacgcg gccaagatct ccaccaccac     2100

gtcggaggag ccctgccgtg acaagggcag ccccgcggtc aaggctcacc ttttcgctgc     2160

tgagcggccc cgggacagcg ggcggctgga caaagcgtcg cccgactcac gccatagccc     2220

cgccaccatc tcgtccagca ctcgcggcct gggcgcggag gagcgcagga gcccggttcg     2280

cgagggcaca gcgccggcca aggtggaaga ggcgcgcgcg ctcccgggca aggaggcctt     2340

cgcgccgctc acggtgcaga cggacgcggc cgccgcgcac ctggcccagg gccccctgcc     2400

tggcctcggc ttcgccccgg gcctggcggg ccaacagttc ttcaacgggc acccgctctt     2460

cctgcacccc agccagtttg ccatgggggg cgccttctcc agcatggcgg ccgctggcat     2520

gggtcccctc ctggccacgg tttctggggc ctccaccggt gtctcgggcc tggattccac     2580

ggccatggcc tctgccgctg cggcgcaggg actgtccggg gcgtccgcgg ccaccctgcc     2640

cttccacctc cagcagcacg tcctggcctc tcagggcctg gccatgtccc ctttcggaag     2700

cctgttccct tacccctaca cgtacatggc cgcagcggcg gccgcctcct ctgcggcagc     2760

ctccagctcg gtgcaccgcc accccttcct caatctgaac accatgcgcc cgcggctgcg     2820

ctacagcccc tactccatcc cggtgccggt cccggacggc agcagtctgc tcaccaccgc     2880

cctgccctcc atggcggcgg ccgcggggcc cctggacggc aaagtcgccg ccctggccgc     2940

cagcccggcc tcggtggcag tggactcggg ctctgaactc aacagccgct cctccacgct     3000

ctcctccagc tccatgtcct tgtcgcccaa actctgcgcg gagaaagagg cggccaccag     3060

cgaactgcag agcatccagc ggttggttag cggcttggaa gccaagccgg acaggtcccg     3120

cagcgcgtcc ccgtagaccc gtcccagaca cgtcttttca ttccagtcca gttcaggctg     3180

ccgtgcactt tgtcggatat aaaataaacc acgggcccgc catggcgtta gcccttcctt     3240

ttgcagttgc gtctgggaag gggccccgga ctccctcgag agaatgtgct agagacagcc     3300

cctgtcttct tggcgtggtt tatatgtccg ggatctggat cagattctgg gggctcagaa     3360

acgtcggttg cattgagcta ctgggggtag gagttccaac atttatgtcc agagcaactt     3420

ccagcaaggc tggtctgggt ctctgcccac caggcgggga ggtgttcaaa gacatctccc     3480

tcagtgcgga tttatatata tatttttcct tcactgtgtc aagtggaaac aaaaacaaaa     3540

tctttcaaaa aaaaaatcgg gacaagtgaa cacattaaca tgattctgtt tgtgcagatt     3600

aaaaacttta tagggacttg cattatcggt tctcaataaa ttactgagca gctttgtttg     3660

gggagggaag tccctaccat ccttgtttag tctatattaa gaaaatctgt gtctttttaa     3720

tattcttgtg atgttttcag agccgctgta ggtctcttct tgcatgtcca cagtaatgta     3780

tttgtggttt ttattttgaa cgcttgcttt tagagagaaa acaatatagc cccctaccct     3840

tttcccaatc ctttgccctc aaatcagtga cccaagggag ggggggattt aaagggaagg     3900

agtgggcaaa acacataaaa tgaatttatt atatctaagc tctgtagcag gattcatgtc     3960

gttctttgac agttctttct ctttcctgta tatgcaataa caaggtttta aaaaaataat     4020

aaagaagtga gactattaga caaagtattt atgtaattat ttgataactc ttgtaaatag     4080

gtggaatatg aatgcttgga aaattaaact ttaatttatt gacattgtac atagctctgt     4140

gtaaatagaa ttgcaactgt caggttttgt gttcttgttt tcctttagtt gggtttattt     4200

ccaggtcaca gaattgctgt taacactaga aaacacactt cctgcaccaa caccaatacc     4260

ctttcaaaag agttgtctgc aacatttttg ttttcttttt taatgtccaa aagtggggga     4320

aagtgctatt tcctattttc accaaaattg gggaaggagt gccactttcc agctccactt     4380

caaattcctt aaaatataac tgagattgct gtggggaggg aggagggcag aggctgcggt     4440

ttgacttttt aatttttctt ttgttatttg tatttgctag tctctgattt cctcaaaacg     4500

aagtggaatt tactactgtt gtcagtatcg gtgttttgaa ttggtgcctg cctatagaga     4560

tatattcaca gttcaaaagt caggtgctga gagatggttt aaagacaaat tcatgaaggt     4620

atattttgtg ttatagttgt tgatgagttc tttggttttc tgtatttttc cccctctctt     4680

taaaacatca ctgaaatttc aataaatttt tattgaaatg tctaaaaaaa aaaaaaaaaa     4740

aaaaaaaaaa aaaa                                                       4754


<210>  131
<211>  4814
<212>  DNA
<213>  Homo sapiens

<400>  131
gaattctaga ggcggcggag ggtggcgagg agctctcgct ttctctcgct ccctccctct       60

ccgactccgt ctctctctct ctctctctct ctcccctccc tctctttccc tctgttccat      120

tttttccccc tctaaatcct ccctgccctg cgcgcctgga cacagattta ggaagcgaat      180

tcgctcacgt tttaggacaa ggaagagaga gaggcacggg agaagagccc agcaagattt      240

ggattgaaac cgagacaccc tccggaggct cggagcagag gaaggaggag gagggcggcg      300

aacggaagcc agtttgcaat tcaagttttg atagcgctgg tagaaggggg tttaaatcag      360

attttttttt ttttaaagga gagagacttt ttccgctctc tcgctccctg ttaaagccgg      420

gtctagcaca gctgcagacg ccaccagcga gaaagaggga gaggaagaca gatagggggc      480

gggggaagaa gaaaaagaaa ggtaaaaagt cttctaggag aacctttcac atttgcaaca      540

aaagacctag gggctggaga gagattcctg ggacgcaggg ctggagtgtc tatttcgagc      600

tcagcggcag ggctcgggcg cgagtcgaga ccctgctcgc tcctctcgct tctgaaaccg      660

acgttcagga gcggcttttt aaaaacgcaa ggcacaagga cggtcacccg cgcgactatg      720

tttgctgatt tttcgccttg ccctctttaa aagcggcctc ccattctcca aaagacactt      780

cccctcctcc ctttgaagtg cattagttgt gatttctgcc tccttttctt ttttctttct      840

tttttgtttt gctttttccc cccttttgaa ttatgtgctg ctgttaaaca acaacaaaaa      900

aacaacaaaa cacagcagct gcggacttgt ccccggctgg agcccagcgc cccgcctgga      960

gtggatgagc ctctccatga gagatccggt cattcctggg acaagcatgg cctaccatcc     1020

gttcctacct caccgggcgc cggacttcgc catgagcgcg gtgctgggtc accagccgcc     1080

gttcttcccc gcgctgacgc tgcctcccaa cggcgcggcg gcgctctcgc tgccgggcgc     1140

cctggccaag ccgatcatgg atcaattggt gggggcggcc gagaccggca tcccgttctc     1200

ctccctgggg ccccaggcgc atctgaggcc tttgaagacc atggagcccg aagaagaggt     1260

ggaggacgac cccaaggtgc acctggaggc taaagaactt tgggatcagt ttcacaagcg     1320

gggcaccgag atggtcatta ccaagtcggg aaggcgaatg tttcctccat ttaaagtgag     1380

atgttctggg ctggataaaa aagccaaata cattttattg atggacatta tagctgctga     1440

tgactgtcgt tataaatttc acaattctcg gtggatggtg gctggtaagg ccgaccccga     1500

aatgccaaag aggatgtaca ttcacccgga cagccccgct actggggaac agtggatgtc     1560

caaagtcgtc actttccaca aactgaaact caccaacaac atttcagaca aacatggatt     1620

tactttggcc ttcccaagtg atcacgctac gtggcagggg aattatagtt ttggtactca     1680

gactatattg aactccatgc acaaatacca gccccggttc cacattgtaa gagccaatga     1740

catcttgaaa ctcccttata gtacatttcg gacatacttg ttccccgaaa ctgaattcat     1800

cgctgtgact gcataccaga atgataagat aacccagtta aaaatagaca acaacccttt     1860

tgcaaaaggt ttccgggaca ctggaaatgg ccgaagagaa aaaagaaaac agctcaccct     1920

gcagtccatg agggtgtttg atgaaagaca caaaaaggag aatgggacct ctgatgagtc     1980

ctccagtgaa caagcagctt tcaactgctt cgcccaggct tcttctccag ccgcctccac     2040

tgtagggaca tcgaacctca aagatttatg tcccagcgag ggtgagagcg acgccgaggc     2100

cgagagcaaa gaggagcatg gccccgaggc ctgcgacgcg gccaagatct ccaccaccac     2160

gtcggaggag ccctgccgtg acaagggcag ccccgcggtc aaggctcacc ttttcgctgc     2220

tgagcggccc cgggacagcg ggcggctgga caaagcgtcg cccgactcac gccatagccc     2280

cgccaccatc tcgtccagca ctcgcggcct gggcgcggag gagcgcagga gcccggttcg     2340

cgagggcaca gcgccggcca aggtggaaga ggcgcgcgcg ctcccgggca aggaggcctt     2400

cgcgccgctc acggtgcaga cggacgcggc cgccgcgcac ctggcccagg gccccctgcc     2460

tggcctcggc ttcgccccgg gcctggcggg ccaacagttc ttcaacgggc acccgctctt     2520

cctgcacccc agccagtttg ccatgggggg cgccttctcc agcatggcgg ccgctggcat     2580

gggtcccctc ctggccacgg tttctggggc ctccaccggt gtctcgggcc tggattccac     2640

ggccatggcc tctgccgctg cggcgcaggg actgtccggg gcgtccgcgg ccaccctgcc     2700

cttccacctc cagcagcacg tcctggcctc tcagggcctg gccatgtccc ctttcggaag     2760

cctgttccct tacccctaca cgtacatggc cgcagcggcg gccgcctcct ctgcggcagc     2820

ctccagctcg gtgcaccgcc accccttcct caatctgaac accatgcgcc cgcggctgcg     2880

ctacagcccc tactccatcc cggtgccggt cccggacggc agcagtctgc tcaccaccgc     2940

cctgccctcc atggcggcgg ccgcggggcc cctggacggc aaagtcgccg ccctggccgc     3000

cagcccggcc tcggtggcag tggactcggg ctctgaactc aacagccgct cctccacgct     3060

ctcctccagc tccatgtcct tgtcgcccaa actctgcgcg gagaaagagg cggccaccag     3120

cgaactgcag agcatccagc ggttggttag cggcttggaa gccaagccgg acaggtcccg     3180

cagcgcgtcc ccgtagaccc gtcccagaca cgtcttttca ttccagtcca gttcaggctg     3240

ccgtgcactt tgtcggatat aaaataaacc acgggcccgc catggcgtta gcccttcctt     3300

ttgcagttgc gtctgggaag gggccccgga ctccctcgag agaatgtgct agagacagcc     3360

cctgtcttct tggcgtggtt tatatgtccg ggatctggat cagattctgg gggctcagaa     3420

acgtcggttg cattgagcta ctgggggtag gagttccaac atttatgtcc agagcaactt     3480

ccagcaaggc tggtctgggt ctctgcccac caggcgggga ggtgttcaaa gacatctccc     3540

tcagtgcgga tttatatata tatttttcct tcactgtgtc aagtggaaac aaaaacaaaa     3600

tctttcaaaa aaaaaatcgg gacaagtgaa cacattaaca tgattctgtt tgtgcagatt     3660

aaaaacttta tagggacttg cattatcggt tctcaataaa ttactgagca gctttgtttg     3720

gggagggaag tccctaccat ccttgtttag tctatattaa gaaaatctgt gtctttttaa     3780

tattcttgtg atgttttcag agccgctgta ggtctcttct tgcatgtcca cagtaatgta     3840

tttgtggttt ttattttgaa cgcttgcttt tagagagaaa acaatatagc cccctaccct     3900

tttcccaatc ctttgccctc aaatcagtga cccaagggag ggggggattt aaagggaagg     3960

agtgggcaaa acacataaaa tgaatttatt atatctaagc tctgtagcag gattcatgtc     4020

gttctttgac agttctttct ctttcctgta tatgcaataa caaggtttta aaaaaataat     4080

aaagaagtga gactattaga caaagtattt atgtaattat ttgataactc ttgtaaatag     4140

gtggaatatg aatgcttgga aaattaaact ttaatttatt gacattgtac atagctctgt     4200

gtaaatagaa ttgcaactgt caggttttgt gttcttgttt tcctttagtt gggtttattt     4260

ccaggtcaca gaattgctgt taacactaga aaacacactt cctgcaccaa caccaatacc     4320

ctttcaaaag agttgtctgc aacatttttg ttttcttttt taatgtccaa aagtggggga     4380

aagtgctatt tcctattttc accaaaattg gggaaggagt gccactttcc agctccactt     4440

caaattcctt aaaatataac tgagattgct gtggggaggg aggagggcag aggctgcggt     4500

ttgacttttt aatttttctt ttgttatttg tatttgctag tctctgattt cctcaaaacg     4560

aagtggaatt tactactgtt gtcagtatcg gtgttttgaa ttggtgcctg cctatagaga     4620

tatattcaca gttcaaaagt caggtgctga gagatggttt aaagacaaat tcatgaaggt     4680

atattttgtg ttatagttgt tgatgagttc tttggttttc tgtatttttc cccctctctt     4740

taaaacatca ctgaaatttc aataaatttt tattgaaatg tctaaaaaaa aaaaaaaaaa     4800

aaaaaaaaaa aaaa                                                       4814


<210>  132
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Glu Leu Pro Thr Lys Pro Gly Thr Phe Asp Leu Gly Leu Ala Thr 
1               5                   10                  15      


Trp Ser Pro Ser Phe Gln Gly Glu Thr His Arg Ala Gln Ala Arg Arg 
            20                  25                  30          


Arg Asp Val Gly Arg Gln Leu Pro Glu Tyr Lys Ala Val Val Val Gly 
        35                  40                  45              


Ala Ser Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Asn His Gln 
    50                  55                  60                  


Cys Phe Val Glu Asp His Asp Pro Thr Ile Gln Asp Ser Tyr Trp Lys 
65                  70                  75                  80  


Glu Leu Thr Leu Asp Ser Gly Asp Cys Ile Leu Asn Val Leu Asp Thr 
                85                  90                  95      


Ala Gly Gln Ala Ile His Arg Ala Leu Arg Asp Gln Cys Leu Ala Val 
            100                 105                 110         


Cys Asp Gly Val Leu Gly Val Phe Ala Leu Asp Asp Pro Ser Ser Leu 
        115                 120                 125             


Ile Gln Leu Gln Gln Ile Trp Ala Thr Trp Gly Pro His Pro Ala Gln 
    130                 135                 140                 


Pro Leu Val Leu Val Gly Asn Lys Cys Asp Leu Val Thr Thr Ala Gly 
145                 150                 155                 160 


Asp Ala His Ala Ala Ala Ala Ala Leu Ala His Ser Trp Gly Ala His 
                165                 170                 175     


Phe Val Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Ser Leu Leu Val His Glu Ile Gln Arg Val Gln Glu Ala Met Ala Lys 
        195                 200                 205             


Glu Pro Met Ala Arg Ser Cys Arg Glu Lys Thr Arg His Gln Lys Ala 
    210                 215                 220                 


Thr Cys His Cys Gly Cys Ser Val Ala 
225                 230             


<210>  133
<211>  826
<212>  DNA
<213>  Homo sapiens

<400>  133
agagcgtccc agcgcgcccg cctccccacg gacacagagc ctgctgccca cgtctcttcc       60

ctgagctgcc tgctggggtc atggagctgc caacaaagcc tggcaccttc gacctgggcc      120

tggccacatg gagcccttcc ttccaggggg aaacccaccg ggctcaggca cgccgcaggg      180

atgttggcag gcagctgcct gagtacaagg ctgtggtggt gggcgccagt ggcgtgggca      240

agagtgcgct gaccatccag ctgaaccacc agtgcttcgt ggaggaccac gaccccacca      300

tccaggattc ctactggaag gagttgaccc tggacagtgg ggactgcatt ctgaatgtgc      360

tggacacagc agggcaggcc atccataggg ccctgcgtga ccagtgcctg gctgtctgtg      420

atggtgtgct gggcgtcttc gctctcgatg acccctcgtc tctgatccag ctgcagcaga      480

tatgggccac ctggggccct caccccgccc agccccttgt cctcgtgggc aacaagtgtg      540

accttgtgac cactgctgga gatgctcatg ccgctgctgc agccctcgca cacagctggg      600

gggcccactt cgtggagacc tcggccaaaa cacggcaagg cgtggaggag gccttttccc      660

tgctggtcca tgagatccag agggtccagg aggccatggc gaaggagccc atggcaaggt      720

cctgtaggga gaagacccgg caccagaagg ccacctgcca ctgtggctgc tctgtggcct      780

gaaggtcttg gccaagaaat gtagaccttt ccccaggcca gggtga                     826


<210>  134
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  135
<211>  4131
<212>  DNA
<213>  Homo sapiens

<400>  135
caaacaagtg cggccatttc accagcccag gctggcttct gctgttgact ggctgtggca       60

cctcaagcag cccctttccc ctctagcctc agtttatcac cgcaagagct accattcatc      120

tagcacaacc tgaccatcct cacactggtc agttccaacc ttcccaggaa tcttctgtgg      180

ccatgttcac tccggtttta cagaacagag aacagaagct cagagaagtg aagcaacttg      240

cccagctatg agagacagag ccaggatttg aaaccagatg aggacgctga ggcccagaga      300

gggaaagcca cttgcctagg gacacacagc ggggagaggt ggagcagggc ctctatttcg      360

agacccctga ctccacacct ggtgtttgtg ccaagacccc aggctgcctc ccaggtcctc      420

tgggacagcc cctgccttct accaggacca tgggtagcaa caagagcaag cccaaggatg      480

ccagccagcg gcgccgcagc ctggagcccg ccgagaacgt gcacggcgct ggcgggggcg      540

ctttccccgc ctcgcagacc cccagcaagc cagcctcggc cgacggccac cgcggcccca      600

gcgcggcctt cgcccccgcg gccgccgagc ccaagctgtt cggaggcttc aactcctcgg      660

acaccgtcac ctccccgcag agggcgggcc cgctggccgg tggagtgacc acctttgtgg      720

ccctctatga ctatgagtct aggacggaga cagacctgtc cttcaagaaa ggcgagcggc      780

tccagattgt caacaacaca gagggagact ggtggctggc ccactcgctc agcacaggac      840

agacaggcta catccccagc aactacgtgg cgccctccga ctccatccag gctgaggagt      900

ggtattttgg caagatcacc agacgggagt cagagcggtt actgctcaat gcagagaacc      960

cgagagggac cttcctcgtg cgagaaagtg agaccacgaa aggtgcctac tgcctctcag     1020

tgtctgactt cgacaacgcc aagggcctca acgtgaagca ctacaagatc cgcaagctgg     1080

acagcggcgg cttctacatc acctcccgca cccagttcaa cagcctgcag cagctggtgg     1140

cctactactc caaacacgcc gatggcctgt gccaccgcct caccaccgtg tgccccacgt     1200

ccaagccgca gactcagggc ctggccaagg atgcctggga gatccctcgg gagtcgctgc     1260

ggctggaggt caagctgggc cagggctgct ttggcgaggt gtggatgggg acctggaacg     1320

gtaccaccag ggtggccatc aaaaccctga agcctggcac gatgtctcca gaggccttcc     1380

tgcaggaggc ccaggtcatg aagaagctga ggcatgagaa gctggtgcag ttgtatgctg     1440

tggtttcaga ggagcccatt tacatcgtca cggagtacat gagcaagggg agtttgctgg     1500

actttctcaa gggggagaca ggcaagtacc tgcggctgcc tcagctggtg gacatggctg     1560

ctcagatcgc ctcaggcatg gcgtacgtgg agcggatgaa ctacgtccac cgggaccttc     1620

gtgcagccaa catcctggtg ggagagaacc tggtgtgcaa agtggccgac tttgggctgg     1680

ctcggctcat tgaagacaat gagtacacgg cgcggcaagg tgccaaattc cccatcaagt     1740

ggacggctcc agaagctgcc ctctatggcc gcttcaccat caagtcggac gtgtggtcct     1800

tcgggatcct gctgactgag ctcaccacaa agggacgggt gccctaccct gggatggtga     1860

accgcgaggt gctggaccag gtggagcggg gctaccggat gccctgcccg ccggagtgtc     1920

ccgagtccct gcacgacctc atgtgccagt gctggcggaa ggagcctgag gagcggccca     1980

ccttcgagta cctgcaggcc ttcctggagg actacttcac gtccaccgag ccccagtacc     2040

agcccgggga gaacctctag gcacaggcgg gcccagaccg gcttctcggc ttggatcctg     2100

ggctgggtgg cccctgtctc ggggcttgcc ccactctgcc tgcctgctgt tggtcctctc     2160

tctgtggggc tgaattgcca ggggcgaggc ccttcctctt tggtggcatg gaaggggctt     2220

ctggacctag ggtggcctga gagggcggtg ggtatgcgag accagcacgg tgactctgtc     2280

cagctcccgc tgtggccgca cgcctctccc tgcactccct cctggagctc tgtgggtctc     2340

tggaagagga accaggagaa gggctggggc cggggctgag ggtgcccttt tccagcctca     2400

gcctactccg ctcactgaac tccttcccca cttctgtgcc acccccggtc tatgtcgaga     2460

gctggccaaa gagcctttcc aaagaggagc gatgggcccc tggccccgcc tgcctgccac     2520

cctgcccctt gccatccatt ctggaaacac ctgtaggcag aggctgccga gacagaccct     2580

ctgccgctgc ttccaggctg ggcagcacaa ggccttgcct ggcctgatga tggtgggtgg     2640

gtgggatgag taccccctca aaccctgccc tccttagacc tgagggaccc ttcgagatca     2700

tcacttcctt gcccccattt cacccatggg gagacagttg agagcgggga tgtgacatgc     2760

ccaaggccac ggagcagttc agagtggagg cgggcttgga acccggtgct ccctctgtca     2820

tcctcaggaa ccaacaattc gtcggaggca tcatggaaag actgggacag cccaggaaac     2880

aaggggtctg aggatgcatt cgagatggca gattcccact gccgctgccc gctcagccca     2940

gctgttggga acagcatgga ggcagatgtg gggctgagct ggggaatcag ggtaaaaggt     3000

gcaggtgtgg agagagaggc ttcaatcggc ttgtgggtga tgtttgacct tcagagccag     3060

ccggctatga aagggagcga gcccctcggc tctggaggca atcaagcaga catagaagag     3120

ccaagagtcc aggaggccct ggtcctggcc tccttccccg tactttgtcc cgtggcattt     3180

caattcctgg ccctgttctc ctccccaagt cggcaccctt taactcatga ggagggaaaa     3240

gagtgcctaa gcgggggtga aagaggacgt gttacccact gccatgcacc aggactggct     3300

gtgtaacctt gggtggcccc tgctgtctct ctgggctgca gagtctgccc cacatgtggc     3360

catggcctct gcaactgctc agctctggtc caggccctgt ggcaggacac acatggtgag     3420

cctagccctg ggacatcagg agactgggct ctggctctgt tcggcctttg ggtgtgtggt     3480

ggattctccc tgggcctcag tgtgcccatc tgtaaagggg cagctgacag tttgtggcat     3540

cttgccaagg gtccctgtgt gtgtgtatgt gtgtgcatgt gtgcgtgtct ccatgtgcgt     3600

ccatatttaa catgtaaaaa tgtccccccc gctccgtccc ccaaacatgt tgtacatttc     3660

accatggccc cctcatcata gcaataacat tcccactgcc aggggttctt gagccagcca     3720

ggccctgcca gtggggaagg aggccaagca gtgcctgcct atgaaatttc aacttttcct     3780

ttcatacgtc tttattaccc aagtcttctc ccgtccattc cagtcaaatc tgggctcact     3840

caccccagcg agctctcaaa tccctctcca actgcctaag gccctttgtg taaggtgtct     3900

taatactgtc cttttttttt ttttaacagt gttttgtaga tttcagatga ctatgcagag     3960

gcctggggga cccctggctc tgggccgggc ctggggctcc gaaattccaa ggcccagact     4020

tgcggggggt gggggggtat ccagaattgg ttgtaaatac tttgcatatt gtctgattaa     4080

acacaaacag acctcagaat ctgatcaaca gttaaaaaaa aaaaaaaaaa a              4131


<210>  136
<211>  4056
<212>  DNA
<213>  Homo sapiens

<400>  136
ggcccggaat ccattccggc ctgggagccg gagcggccag gccgccgtct gcccgtcccg       60

ctggacgtcc cgcggtccgc cctcccgtgc gtccgtctgc cggtgagccc gcccgcccgc      120

cggcccagaa cagagaacag aagctcagag aagtgaagca acttgcccag ctatgagaga      180

cagagccagg atttgaaacc agatgaggac gctgaggccc agagagggaa agccacttgc      240

ctagggacac acagcgggga gaggtggagc agggcctcta tttcgagacc cctgactcca      300

cacctggtgt ttgtgccaag accccaggct gcctcccagg tcctctggga cagcccctgc      360

cttctaccag gaccatgggt agcaacaaga gcaagcccaa ggatgccagc cagcggcgcc      420

gcagcctgga gcccgccgag aacgtgcacg gcgctggcgg gggcgctttc cccgcctcgc      480

agacccccag caagccagcc tcggccgacg gccaccgcgg ccccagcgcg gccttcgccc      540

ccgcggccgc cgagcccaag ctgttcggag gcttcaactc ctcggacacc gtcacctccc      600

cgcagagggc gggcccgctg gccggtggag tgaccacctt tgtggccctc tatgactatg      660

agtctaggac ggagacagac ctgtccttca agaaaggcga gcggctccag attgtcaaca      720

acacagaggg agactggtgg ctggcccact cgctcagcac aggacagaca ggctacatcc      780

ccagcaacta cgtggcgccc tccgactcca tccaggctga ggagtggtat tttggcaaga      840

tcaccagacg ggagtcagag cggttactgc tcaatgcaga gaacccgaga gggaccttcc      900

tcgtgcgaga aagtgagacc acgaaaggtg cctactgcct ctcagtgtct gacttcgaca      960

acgccaaggg cctcaacgtg aagcactaca agatccgcaa gctggacagc ggcggcttct     1020

acatcacctc ccgcacccag ttcaacagcc tgcagcagct ggtggcctac tactccaaac     1080

acgccgatgg cctgtgccac cgcctcacca ccgtgtgccc cacgtccaag ccgcagactc     1140

agggcctggc caaggatgcc tgggagatcc ctcgggagtc gctgcggctg gaggtcaagc     1200

tgggccaggg ctgctttggc gaggtgtgga tggggacctg gaacggtacc accagggtgg     1260

ccatcaaaac cctgaagcct ggcacgatgt ctccagaggc cttcctgcag gaggcccagg     1320

tcatgaagaa gctgaggcat gagaagctgg tgcagttgta tgctgtggtt tcagaggagc     1380

ccatttacat cgtcacggag tacatgagca aggggagttt gctggacttt ctcaaggggg     1440

agacaggcaa gtacctgcgg ctgcctcagc tggtggacat ggctgctcag atcgcctcag     1500

gcatggcgta cgtggagcgg atgaactacg tccaccggga ccttcgtgca gccaacatcc     1560

tggtgggaga gaacctggtg tgcaaagtgg ccgactttgg gctggctcgg ctcattgaag     1620

acaatgagta cacggcgcgg caaggtgcca aattccccat caagtggacg gctccagaag     1680

ctgccctcta tggccgcttc accatcaagt cggacgtgtg gtccttcggg atcctgctga     1740

ctgagctcac cacaaaggga cgggtgccct accctgggat ggtgaaccgc gaggtgctgg     1800

accaggtgga gcggggctac cggatgccct gcccgccgga gtgtcccgag tccctgcacg     1860

acctcatgtg ccagtgctgg cggaaggagc ctgaggagcg gcccaccttc gagtacctgc     1920

aggccttcct ggaggactac ttcacgtcca ccgagcccca gtaccagccc ggggagaacc     1980

tctaggcaca ggcgggccca gaccggcttc tcggcttgga tcctgggctg ggtggcccct     2040

gtctcggggc ttgccccact ctgcctgcct gctgttggtc ctctctctgt ggggctgaat     2100

tgccaggggc gaggcccttc ctctttggtg gcatggaagg ggcttctgga cctagggtgg     2160

cctgagaggg cggtgggtat gcgagaccag cacggtgact ctgtccagct cccgctgtgg     2220

ccgcacgcct ctccctgcac tccctcctgg agctctgtgg gtctctggaa gaggaaccag     2280

gagaagggct ggggccgggg ctgagggtgc ccttttccag cctcagccta ctccgctcac     2340

tgaactcctt ccccacttct gtgccacccc cggtctatgt cgagagctgg ccaaagagcc     2400

tttccaaaga ggagcgatgg gcccctggcc ccgcctgcct gccaccctgc cccttgccat     2460

ccattctgga aacacctgta ggcagaggct gccgagacag accctctgcc gctgcttcca     2520

ggctgggcag cacaaggcct tgcctggcct gatgatggtg ggtgggtggg atgagtaccc     2580

cctcaaaccc tgccctcctt agacctgagg gacccttcga gatcatcact tccttgcccc     2640

catttcaccc atggggagac agttgagagc ggggatgtga catgcccaag gccacggagc     2700

agttcagagt ggaggcgggc ttggaacccg gtgctccctc tgtcatcctc aggaaccaac     2760

aattcgtcgg aggcatcatg gaaagactgg gacagcccag gaaacaaggg gtctgaggat     2820

gcattcgaga tggcagattc ccactgccgc tgcccgctca gcccagctgt tgggaacagc     2880

atggaggcag atgtggggct gagctgggga atcagggtaa aaggtgcagg tgtggagaga     2940

gaggcttcaa tcggcttgtg ggtgatgttt gaccttcaga gccagccggc tatgaaaggg     3000

agcgagcccc tcggctctgg aggcaatcaa gcagacatag aagagccaag agtccaggag     3060

gccctggtcc tggcctcctt ccccgtactt tgtcccgtgg catttcaatt cctggccctg     3120

ttctcctccc caagtcggca ccctttaact catgaggagg gaaaagagtg cctaagcggg     3180

ggtgaaagag gacgtgttac ccactgccat gcaccaggac tggctgtgta accttgggtg     3240

gcccctgctg tctctctggg ctgcagagtc tgccccacat gtggccatgg cctctgcaac     3300

tgctcagctc tggtccaggc cctgtggcag gacacacatg gtgagcctag ccctgggaca     3360

tcaggagact gggctctggc tctgttcggc ctttgggtgt gtggtggatt ctccctgggc     3420

ctcagtgtgc ccatctgtaa aggggcagct gacagtttgt ggcatcttgc caagggtccc     3480

tgtgtgtgtg tatgtgtgtg catgtgtgcg tgtctccatg tgcgtccata tttaacatgt     3540

aaaaatgtcc cccccgctcc gtcccccaaa catgttgtac atttcaccat ggccccctca     3600

tcatagcaat aacattccca ctgccagggg ttcttgagcc agccaggccc tgccagtggg     3660

gaaggaggcc aagcagtgcc tgcctatgaa atttcaactt ttcctttcat acgtctttat     3720

tacccaagtc ttctcccgtc cattccagtc aaatctgggc tcactcaccc cagcgagctc     3780

tcaaatccct ctccaactgc ctaaggccct ttgtgtaagg tgtcttaata ctgtcctttt     3840

ttttttttta acagtgtttt gtagatttca gatgactatg cagaggcctg ggggacccct     3900

ggctctgggc cgggcctggg gctccgaaat tccaaggccc agacttgcgg ggggtggggg     3960

ggtatccaga attggttgta aatactttgc atattgtctg attaaacaca aacagacctc     4020

agaatctgat caacagttaa aaaaaaaaaa aaaaaa                               4056


<210>  137
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Gly Leu Ser Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser 
1               5                   10                  15      


Glu Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu 
            20                  25                  30          


Asp Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu 
        35                  40                  45              


Glu Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg 
    50                  55                  60                  


Val Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys 
65                  70                  75                  80  


Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr 
                85                  90                  95      


Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val 
            100                 105                 110         


Arg Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met 
        115                 120                 125             


Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly 
    130                 135                 140                 


Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu 
145                 150                 155                 160 


Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys 
                165                 170                 175     


Pro Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp 
            180                 185                 190         


Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly 
        195                 200                 205             


Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn 
    210                 215                 220                 


Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala 
225                 230                 235                 240 


Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu 
                245                 250                 255     


Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp 
            260                 265                 270         


Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg 
        275                 280                 285             


Phe Gly Asn Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp 
    290                 295                 300                 


Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala 
305                 310                 315                 320 


Pro Phe Ile Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp 
                325                 330                 335     


Asp Tyr Glu Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala 
            340                 345                 350         


Lys Glu Phe Gly Glu Phe 
        355             


<210>  138
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gly Leu Leu Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
1               5                   10                  15      


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
            20                  25                  30          


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
        35                  40                  45              


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
    50                  55                  60                  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
65                  70                  75                  80  


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
                85                  90                  95      


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
            100                 105                 110         


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
        115                 120                 125             


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
    130                 135                 140                 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
145                 150                 155                 160 


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
                165                 170                 175     


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
            180                 185                 190         


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
        195                 200                 205             


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
    210                 215                 220                 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
225                 230                 235                 240 


Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp 
                245                 250                 255     


Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn 
            260                 265                 270         


Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr 
        275                 280                 285             


Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile 
    290                 295                 300                 


Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu 
305                 310                 315                 320 


Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe 
                325                 330                 335     


Gly Glu Phe 
            


<210>  139
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gly Leu Ser Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser 
1               5                   10                  15      


Glu Ile Ser Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu 
            20                  25                  30          


Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe 
        35                  40                  45              


Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu 
    50                  55                  60                  


Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp 
65                  70                  75                  80  


Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu 
                85                  90                  95      


Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu 
            100                 105                 110         


Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val 
        115                 120                 125             


Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser 
    130                 135                 140                 


Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu 
145                 150                 155                 160 


Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn 
                165                 170                 175     


Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe 
            180                 185                 190         


Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu 
        195                 200                 205             


Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val 
    210                 215                 220                 


Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr 
225                 230                 235                 240 


Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val 
                245                 250                 255     


Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp 
            260                 265                 270         


Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn 
        275                 280                 285             


Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr 
    290                 295                 300                 


Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile 
305                 310                 315                 320 


Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu 
                325                 330                 335     


Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe 
            340                 345                 350         


Gly Glu Phe 
        355 


<210>  140
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Asp Ser Phe Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp 
            20                  25                  30          


Phe Leu Lys Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu 
        35                  40                  45              


Asp Phe Glu Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val 
    50                  55                  60                  


Met Leu Val Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile 
65                  70                  75                  80  


Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu 
                85                  90                  95      


Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg 
            100                 105                 110         


Leu Glu Tyr Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu 
        115                 120                 125             


Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg 
    130                 135                 140                 


Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr 
145                 150                 155                 160 


Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro 
                165                 170                 175     


Glu Asn Leu Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe 
            180                 185                 190         


Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr 
        195                 200                 205             


Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys 
    210                 215                 220                 


Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala 
225                 230                 235                 240 


Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys 
                245                 250                 255     


Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu 
            260                 265                 270         


Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe 
        275                 280                 285             


Gly Asn Leu Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe 
    290                 295                 300                 


Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro 
305                 310                 315                 320 


Phe Ile Pro Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp 
                325                 330                 335     


Tyr Glu Glu Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys 
            340                 345                 350         


Glu Phe Gly Glu Phe 
        355         


<210>  141
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ser Ala Arg Lys Ser Ser Asp Ala Ser Ala Cys Ser Ser Ser Glu 
1               5                   10                  15      


Ile Ser Val Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys 
            20                  25                  30          


Lys Trp Glu Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu 
        35                  40                  45              


Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val 
    50                  55                  60                  


Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys 
65                  70                  75                  80  


Gln Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly 
                85                  90                  95      


Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro 
            100                 105                 110         


His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu 
        115                 120                 125             


His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu 
    130                 135                 140                 


Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys 
145                 150                 155                 160 


Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu 
                165                 170                 175     


Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp 
            180                 185                 190         


Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro 
        195                 200                 205             


Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly 
    210                 215                 220                 


Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu 
225                 230                 235                 240 


Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys 
                245                 250                 255     


Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp 
            260                 265                 270         


Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys 
        275                 280                 285             


Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu 
    290                 295                 300                 


Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu 
305                 310                 315                 320 


Phe 
    


<210>  142
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Leu Leu Leu Ser Ser Ser Ile Ser Leu Tyr Lys Asp Arg Asn Glu 
1               5                   10                  15      


Ala Arg Leu Ile Ser Ser Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu 
            20                  25                  30          


Arg Lys Lys Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val 
        35                  40                  45              


Lys His Lys Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys 
    50                  55                  60                  


Gln Lys Val Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys 
65                  70                  75                  80  


Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr 
                85                  90                  95      


Ala Phe Lys Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro 
            100                 105                 110         


Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu 
        115                 120                 125             


Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr 
    130                 135                 140                 


Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu 
145                 150                 155                 160 


Leu Ile Asp His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala 
                165                 170                 175     


Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr 
            180                 185                 190         


Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp 
        195                 200                 205             


Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro 
    210                 215                 220                 


Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser 
225                 230                 235                 240 


Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu 
                245                 250                 255     


Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu 
            260                 265                 270         


Lys Asn Gly Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr 
        275                 280                 285             


Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro 
    290                 295                 300                 


Lys Phe Arg Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu 
305                 310                 315                 320 


Glu Asp Ile Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly 
                325                 330                 335     


Glu Phe 
        


<210>  143
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg 
305                 310                 315                 320 


Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile 
                325                 330                 335     


Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
            340                 345                 350     


<210>  144
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ala Ala Tyr Arg Glu Pro Pro Cys Asn Gln Tyr Thr Gly Thr Thr 
1               5                   10                  15      


Thr Ala Leu Gln Lys Leu Glu Gly Phe Ala Ser Arg Leu Phe His Arg 
            20                  25                  30          


His Ser Lys Gly Thr Ala His Asp Gln Lys Thr Ala Leu Glu Asn Asp 
        35                  40                  45              


Ser Leu His Phe Ser Glu His Thr Ala Leu Trp Asp Arg Ser Met Lys 
    50                  55                  60                  


Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu Asn 
65                  70                  75                  80  


Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys Thr 
                85                  90                  95      


Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys Ala 
            100                 105                 110         


Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val Val 
        115                 120                 125             


Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu Gln 
    130                 135                 140                 


Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys Asp 
145                 150                 155                 160 


Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu Met 
                165                 170                 175     


Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala Arg 
            180                 185                 190         


Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser Leu 
        195                 200                 205             


Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp His 
    210                 215                 220                 


Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val Lys 
225                 230                 235                 240 


Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu 
                245                 250                 255     


Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala Leu 
            260                 265                 270         


Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe Ala 
        275                 280                 285             


Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val Arg 
    290                 295                 300                 


Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn Leu 
305                 310                 315                 320 


Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly Val 
                325                 330                 335     


Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile Ala 
            340                 345                 350         


Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg Gly 
        355                 360                 365             


Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile Arg 
    370                 375                 380                 


Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
385                 390                 395             


<210>  145
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Asn 
                245                 250                 255     


Phe 
    


<210>  146
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


<210>  147
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ala Ser Asn Ser Ser Asp Val Lys Glu Phe Leu Ala Lys Ala Lys 
1               5                   10                  15      


Glu Asp Phe Leu Lys Lys Trp Glu Ser Pro Ala Gln Asn Thr Ala His 
            20                  25                  30          


Leu Asp Gln Phe Glu Arg Ile Lys Thr Leu Gly Thr Gly Ser Phe Gly 
        35                  40                  45              


Arg Val Met Leu Val Lys His Lys Glu Thr Gly Asn His Tyr Ala Met 
    50                  55                  60                  


Lys Ile Leu Asp Lys Gln Lys Val Val Lys Leu Lys Gln Ile Glu His 
65                  70                  75                  80  


Thr Leu Asn Glu Lys Arg Ile Leu Gln Ala Val Asn Phe Pro Phe Leu 
                85                  90                  95      


Val Lys Leu Glu Phe Ser Phe Lys Asp Asn Ser Asn Leu Tyr Met Val 
            100                 105                 110         


Met Glu Tyr Val Pro Gly Gly Glu Met Phe Ser His Leu Arg Arg Ile 
        115                 120                 125             


Gly Arg Phe Ser Glu Pro His Ala Arg Phe Tyr Ala Ala Gln Ile Val 
    130                 135                 140                 


Leu Thr Phe Glu Tyr Leu His Ser Leu Asp Leu Ile Tyr Arg Asp Leu 
145                 150                 155                 160 


Lys Pro Glu Asn Leu Leu Ile Asp Gln Gln Gly Tyr Ile Gln Val Thr 
                165                 170                 175     


Asp Phe Gly Phe Ala Lys Arg Val Lys Gly Arg Thr Trp Thr Leu Cys 
            180                 185                 190         


Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Ile Leu Ser Lys Gly Tyr 
        195                 200                 205             


Asn Lys Ala Val Asp Trp Trp Ala Leu Gly Val Leu Ile Tyr Glu Met 
    210                 215                 220                 


Ala Ala Gly Tyr Pro Pro Phe Phe Ala Asp Gln Pro Ile Gln Ile Tyr 
225                 230                 235                 240 


Glu Lys Ile Val Ser Gly Lys Val Arg Phe Pro Ser His Phe Ser Ser 
                245                 250                 255     


Asp Leu Lys Asp Leu Leu Arg Asn Leu Leu Gln Val Asp Leu Thr Lys 
            260                 265                 270         


Arg Phe Gly Asn Leu Lys Asn Gly Val Asn Asp Ile Lys Asn His Lys 
        275                 280                 285             


Trp Phe Ala Thr Thr Asp Trp Ile Ala Ile Tyr Gln Arg Lys Val Glu 
    290                 295                 300                 


Ala Pro Phe Ile Pro Lys Phe Lys Gly Pro Gly Asp Thr Ser Asn Phe 
305                 310                 315                 320 


Asp Asp Tyr Glu Glu Glu Glu Ile Arg Val Ser Ile Asn Glu Lys Cys 
                325                 330                 335     


Gly Lys Glu Phe Ser Glu Phe 
            340             


<210>  148
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  149
<211>  1537
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Gly Glu Lys Leu Glu Leu Arg Leu Lys Ser Pro Val Gly Ala Glu 
1               5                   10                  15      


Pro Ala Val Tyr Pro Trp Pro Leu Pro Val Tyr Asp Lys His His Asp 
            20                  25                  30          


Ala Ala His Glu Ile Ile Glu Thr Ile Arg Trp Val Cys Glu Glu Ile 
        35                  40                  45              


Pro Asp Leu Lys Leu Ala Met Glu Asn Tyr Val Leu Ile Asp Tyr Asp 
    50                  55                  60                  


Thr Lys Ser Phe Glu Ser Met Gln Arg Leu Cys Asp Lys Tyr Asn Arg 
65                  70                  75                  80  


Ala Ile Asp Ser Ile His Gln Leu Trp Lys Gly Thr Thr Gln Pro Met 
                85                  90                  95      


Lys Leu Asn Thr Arg Pro Ser Thr Gly Leu Leu Arg His Ile Leu Gln 
            100                 105                 110         


Gln Val Tyr Asn His Ser Val Thr Asp Pro Glu Lys Leu Asn Asn Tyr 
        115                 120                 125             


Glu Pro Phe Ser Pro Glu Val Tyr Gly Glu Thr Ser Phe Asp Leu Val 
    130                 135                 140                 


Ala Gln Met Ile Asp Glu Ile Lys Met Thr Asp Asp Asp Leu Phe Val 
145                 150                 155                 160 


Asp Leu Gly Ser Gly Val Gly Gln Val Val Leu Gln Val Ala Ala Ala 
                165                 170                 175     


Thr Asn Cys Lys His His Tyr Gly Val Glu Lys Ala Asp Ile Pro Ala 
            180                 185                 190         


Lys Tyr Ala Glu Thr Met Asp Arg Glu Phe Arg Lys Trp Met Lys Trp 
        195                 200                 205             


Tyr Gly Lys Lys His Ala Glu Tyr Thr Leu Glu Arg Gly Asp Phe Leu 
    210                 215                 220                 


Ser Glu Glu Trp Arg Glu Arg Ile Ala Asn Thr Ser Val Ile Phe Val 
225                 230                 235                 240 


Asn Asn Phe Ala Phe Gly Pro Glu Val Asp His Gln Leu Lys Glu Arg 
                245                 250                 255     


Phe Ala Asn Met Lys Glu Gly Gly Arg Ile Val Ser Ser Lys Pro Phe 
            260                 265                 270         


Ala Pro Leu Asn Phe Arg Ile Asn Ser Arg Asn Leu Ser Asp Ile Gly 
        275                 280                 285             


Thr Ile Met Arg Val Val Glu Leu Ser Pro Leu Lys Gly Ser Val Ser 
    290                 295                 300                 


Trp Thr Gly Lys Pro Val Ser Tyr Tyr Leu His Thr Ile Asp Arg Thr 
305                 310                 315                 320 


Ile Leu Glu Asn Tyr Phe Ser Ser Leu Lys Asn Pro Lys Leu Arg Glu 
                325                 330                 335     


Glu Gln Glu Ala Ala Arg Arg Arg Gln Gln Arg Glu Ser Lys Ser Asn 
            340                 345                 350         


Ala Ala Thr Pro Thr Lys Gly Pro Glu Gly Lys Val Ala Gly Pro Ala 
        355                 360                 365             


Asp Ala Pro Met Asp Ser Gly Ala Glu Glu Glu Lys Ala Gly Ala Ala 
    370                 375                 380                 


Thr Val Lys Lys Pro Ser Pro Ser Lys Ala Arg Lys Lys Lys Leu Asn 
385                 390                 395                 400 


Lys Lys Gly Arg Lys Met Ala Gly Arg Lys Arg Gly Arg Pro Lys Lys 
                405                 410                 415     


Met Asn Thr Ala Asn Pro Glu Arg Lys Pro Lys Lys Asn Gln Thr Ala 
            420                 425                 430         


Leu Asp Ala Leu His Ala Gln Thr Val Ser Gln Thr Ala Ala Ser Ser 
        435                 440                 445             


Pro Gln Asp Ala Tyr Arg Ser Pro His Ser Pro Phe Tyr Gln Leu Pro 
    450                 455                 460                 


Pro Ser Val Gln Arg His Ser Pro Asn Pro Leu Leu Val Ala Pro Thr 
465                 470                 475                 480 


Pro Pro Ala Leu Gln Lys Leu Leu Glu Ser Phe Lys Ile Gln Tyr Leu 
                485                 490                 495     


Gln Phe Leu Ala Tyr Thr Lys Thr Pro Gln Tyr Lys Ala Ser Leu Gln 
            500                 505                 510         


Glu Leu Leu Gly Gln Glu Lys Glu Lys Asn Ala Gln Leu Leu Gly Ala 
        515                 520                 525             


Ala Gln Gln Leu Leu Ser His Cys Gln Ala Gln Lys Glu Glu Ile Arg 
    530                 535                 540                 


Arg Leu Phe Gln Gln Lys Leu Asp Glu Leu Gly Val Lys Ala Leu Thr 
545                 550                 555                 560 


Tyr Asn Asp Leu Ile Gln Ala Gln Lys Glu Ile Ser Ala His Asn Gln 
                565                 570                 575     


Gln Leu Arg Glu Gln Ser Glu Gln Leu Glu Gln Asp Asn Arg Ala Leu 
            580                 585                 590         


Arg Gly Gln Ser Leu Gln Leu Leu Lys Ala Arg Cys Glu Glu Leu Gln 
        595                 600                 605             


Leu Asp Trp Ala Thr Leu Ser Leu Glu Lys Leu Leu Lys Glu Lys Gln 
    610                 615                 620                 


Ala Leu Lys Ser Gln Ile Ser Glu Lys Gln Arg His Cys Leu Glu Leu 
625                 630                 635                 640 


Gln Ile Ser Ile Val Glu Leu Glu Lys Ser Gln Arg Gln Gln Glu Leu 
                645                 650                 655     


Leu Gln Leu Lys Ser Cys Val Pro Pro Asp Asp Ala Leu Ser Leu His 
            660                 665                 670         


Leu Arg Gly Lys Gly Ala Leu Gly Arg Glu Leu Glu Pro Asp Ala Ser 
        675                 680                 685             


Arg Leu His Leu Glu Leu Asp Cys Thr Lys Phe Ser Leu Pro His Leu 
    690                 695                 700                 


Ser Ser Met Ser Pro Glu Leu Ser Met Asn Gly Gln Ala Ala Gly Tyr 
705                 710                 715                 720 


Glu Leu Cys Gly Val Leu Ser Arg Pro Ser Ser Lys Gln Asn Thr Pro 
                725                 730                 735     


Gln Tyr Leu Ala Ser Pro Leu Asp Gln Glu Val Val Pro Cys Thr Pro 
            740                 745                 750         


Ser His Val Gly Arg Pro Arg Leu Glu Lys Leu Ser Gly Leu Ala Ala 
        755                 760                 765             


Pro Asp Tyr Thr Arg Leu Ser Pro Ala Lys Ile Val Leu Arg Arg His 
    770                 775                 780                 


Leu Ser Gln Asp His Thr Val Pro Gly Arg Pro Ala Ala Ser Glu Leu 
785                 790                 795                 800 


His Ser Arg Ala Glu His Thr Lys Glu Asn Gly Leu Pro Tyr Gln Ser 
                805                 810                 815     


Pro Ser Val Pro Gly Ser Met Lys Leu Ser Pro Gln Asp Pro Arg Pro 
            820                 825                 830         


Leu Ser Pro Gly Ala Leu Gln Leu Ala Gly Glu Lys Ser Ser Glu Lys 
        835                 840                 845             


Gly Leu Arg Glu Arg Ala Tyr Gly Ser Ser Gly Glu Leu Ile Thr Ser 
    850                 855                 860                 


Leu Pro Ile Ser Ile Pro Leu Ser Thr Val Gln Pro Asn Lys Leu Pro 
865                 870                 875                 880 


Val Ser Ile Pro Leu Ala Ser Val Val Leu Pro Ser Arg Ala Glu Arg 
                885                 890                 895     


Ala Arg Ser Thr Pro Ser Pro Val Leu Gln Pro Arg Asp Pro Ser Ser 
            900                 905                 910         


Thr Leu Glu Lys Gln Ile Gly Ala Asn Ala His Gly Ala Gly Ser Arg 
        915                 920                 925             


Ser Leu Ala Leu Ala Pro Ala Gly Phe Ser Tyr Ala Gly Ser Val Ala 
    930                 935                 940                 


Ile Ser Gly Ala Leu Ala Gly Ser Pro Ala Ser Leu Thr Pro Gly Ala 
945                 950                 955                 960 


Glu Pro Ala Thr Leu Asp Glu Ser Ser Ser Ser Gly Ser Leu Phe Ala 
                965                 970                 975     


Thr Val Gly Ser Arg Ser Ser Thr Pro Gln His Pro Leu Leu Leu Ala 
            980                 985                 990         


Gln Pro Arg Asn Ser Leu Pro Ala  Ser Pro Ala His Gln  Leu Ser Ser 
        995                 1000                 1005             


Ser Pro  Arg Leu Gly Gly Ala  Ala Gln Gly Pro Leu  Pro Glu Ala 
    1010                 1015                 1020             


Ser Lys  Gly Asp Leu Pro Ser  Asp Ser Gly Phe Ser  Asp Pro Glu 
    1025                 1030                 1035             


Ser Glu  Ala Lys Arg Arg Ile  Val Phe Thr Ile Thr  Thr Gly Ala 
    1040                 1045                 1050             


Gly Ser  Ala Lys Gln Ser Pro  Ser Ser Lys His Ser  Pro Leu Thr 
    1055                 1060                 1065             


Ala Ser  Ala Arg Gly Asp Cys  Val Pro Ser His Gly  Gln Asp Ser 
    1070                 1075                 1080             


Arg Arg  Arg Gly Arg Arg Lys  Arg Ala Ser Ala Gly  Thr Pro Ser 
    1085                 1090                 1095             


Leu Ser  Ala Gly Val Ser Pro  Lys Arg Arg Ala Leu  Pro Ser Val 
    1100                 1105                 1110             


Ala Gly  Leu Phe Thr Gln Pro  Ser Gly Ser Pro Leu  Asn Leu Asn 
    1115                 1120                 1125             


Ser Met  Val Ser Asn Ile Asn  Gln Pro Leu Glu Ile  Thr Ala Ile 
    1130                 1135                 1140             


Ser Ser  Pro Glu Thr Ser Leu  Lys Ser Ser Pro Val  Pro Tyr Gln 
    1145                 1150                 1155             


Asp His  Asp Gln Pro Pro Val  Leu Lys Lys Glu Arg  Pro Leu Ser 
    1160                 1165                 1170             


Gln Thr  Asn Gly Ala His Tyr  Ser Pro Leu Thr Ser  Asp Glu Glu 
    1175                 1180                 1185             


Pro Gly  Ser Glu Asp Glu Pro  Ser Ser Ala Arg Ile  Glu Arg Lys 
    1190                 1195                 1200             


Ile Ala  Thr Ile Ser Leu Glu  Ser Lys Ser Pro Pro  Lys Thr Leu 
    1205                 1210                 1215             


Glu Asn  Gly Gly Gly Leu Ala  Gly Arg Lys Pro Ala  Pro Ala Gly 
    1220                 1225                 1230             


Glu Pro  Val Asn Ser Ser Lys  Trp Lys Ser Thr Phe  Ser Pro Ile 
    1235                 1240                 1245             


Ser Asp  Ile Gly Leu Ala Lys  Ser Ala Asp Ser Pro  Leu Gln Ala 
    1250                 1255                 1260             


Ser Ser  Ala Leu Ser Gln Asn  Ser Leu Phe Thr Phe  Arg Pro Ala 
    1265                 1270                 1275             


Leu Glu  Glu Pro Ser Ala Asp  Ala Lys Leu Ala Ala  His Pro Arg 
    1280                 1285                 1290             


Lys Gly  Phe Pro Gly Ser Leu  Ser Gly Ala Asp Gly  Leu Ser Pro 
    1295                 1300                 1305             


Gly Thr  Asn Pro Ala Asn Gly  Cys Thr Phe Gly Gly  Gly Leu Ala 
    1310                 1315                 1320             


Ala Asp  Leu Ser Leu His Ser  Phe Ser Asp Gly Ala  Ser Leu Pro 
    1325                 1330                 1335             


His Lys  Gly Pro Glu Ala Ala  Gly Leu Ser Ser Pro  Leu Ser Phe 
    1340                 1345                 1350             


Pro Ser  Gln Arg Gly Lys Glu  Gly Ser Asp Ala Asn  Pro Phe Leu 
    1355                 1360                 1365             


Ser Lys  Arg Gln Leu Asp Gly  Leu Ala Gly Leu Lys  Gly Glu Gly 
    1370                 1375                 1380             


Ser Arg  Gly Lys Glu Ala Gly  Glu Gly Gly Leu Pro  Leu Cys Gly 
    1385                 1390                 1395             


Pro Thr  Asp Lys Thr Pro Leu  Leu Ser Gly Lys Ala  Ala Lys Ala 
    1400                 1405                 1410             


Arg Asp  Arg Glu Val Asp Leu  Lys Asn Gly His Asn  Leu Phe Ile 
    1415                 1420                 1425             


Ser Ala  Ala Ala Val Pro Pro  Gly Ser Leu Leu Ser  Gly Pro Gly 
    1430                 1435                 1440             


Leu Ala  Pro Ala Ala Ser Ser  Ala Gly Gly Ala Ala  Ser Ser Ala 
    1445                 1450                 1455             


Gln Thr  His Arg Ser Phe Leu  Gly Pro Phe Pro Pro  Gly Pro Gln 
    1460                 1465                 1470             


Phe Ala  Leu Gly Pro Met Ser  Leu Gln Ala Asn Leu  Gly Ser Val 
    1475                 1480                 1485             


Ala Gly  Ser Ser Val Leu Gln  Ser Leu Phe Ser Ser  Val Pro Ala 
    1490                 1495                 1500             


Ala Ala  Gly Leu Val His Val  Ser Ser Ala Ala Thr  Arg Leu Thr 
    1505                 1510                 1515             


Asn Ser  His Ala Met Gly Ser  Phe Ser Gly Val Ala  Gly Gly Thr 
    1520                 1525                 1530             


Val Gly  Gly Asn 
    1535         


<210>  150
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Thr Glu Glu Ala Cys Arg Thr Arg Ser Gln Lys Arg Ala Leu Glu 
1               5                   10                  15      


Arg Asp Pro Thr Glu Asp Asp Val Glu Ser Lys Lys Ile Lys Met Glu 
            20                  25                  30          


Arg Gly Leu Leu Ala Ser Asp Leu Asn Thr Asp Gly Asp Met Arg Val 
        35                  40                  45              


Thr Pro Glu Pro Gly Ala Gly Pro Thr Gln Gly Leu Leu Arg Ala Thr 
    50                  55                  60                  


Glu Ala Thr Ala Met Ala Met Gly Arg Gly Glu Gly Leu Val Gly Asp 
65                  70                  75                  80  


Gly Pro Val Asp Met Arg Thr Ser His Ser Asp Met Lys Ser Glu Arg 
                85                  90                  95      


Arg Pro Pro Ser Pro Asp Val Ile Val Leu Ser Asp Asn Glu Gln Pro 
            100                 105                 110         


Ser Ser Pro Arg Val Asn Gly Leu Thr Thr Val Ala Leu Lys Glu Thr 
        115                 120                 125             


Ser Thr Glu Ala Leu Met Lys Ser Ser Pro Glu Glu Arg Glu Arg Met 
    130                 135                 140                 


Ile Lys Gln Leu Lys Glu Glu Leu Arg Leu Glu Glu Ala Lys Leu Val 
145                 150                 155                 160 


Leu Leu Lys Lys Leu Arg Gln Ser Gln Ile Gln Lys Glu Ala Thr Ala 
                165                 170                 175     


Gln Lys Pro Thr Gly Ser Val Gly Ser Thr Val Thr Thr Pro Pro Pro 
            180                 185                 190         


Leu Val Arg Gly Thr Gln Asn Ile Pro Ala Gly Lys Pro Ser Leu Gln 
        195                 200                 205             


Thr Ser Ser Ala Arg Met Pro Gly Ser Val Ile Pro Pro Pro Leu Val 
    210                 215                 220                 


Arg Gly Gly Gln Gln Ala Ser Ser Lys Leu Gly Pro Gln Ala Ser Ser 
225                 230                 235                 240 


Gln Val Val Met Pro Pro Leu Val Arg Gly Ala Gln Gln Ile His Ser 
                245                 250                 255     


Ile Arg Gln His Ser Ser Thr Gly Pro Pro Pro Leu Leu Leu Ala Pro 
            260                 265                 270         


Arg Ala Ser Val Pro Ser Val Gln Ile Gln Gly Gln Arg Ile Ile Gln 
        275                 280                 285             


Gln Gly Leu Ile Arg Val Ala Asn Val Pro Asn Thr Ser Leu Leu Val 
    290                 295                 300                 


Asn Ile Pro Gln Pro Thr Pro Ala Ser Leu Lys Gly Thr Thr Ala Thr 
305                 310                 315                 320 


Ser Ala Gln Ala Asn Ser Thr Pro Thr Ser Val Ala Ser Val Val Thr 
                325                 330                 335     


Ser Ala Glu Ser Pro Ala Ser Arg Gln Ala Ala Ala Lys Leu Ala Leu 
            340                 345                 350         


Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro Pro Pro Lys Pro 
        355                 360                 365             


Pro Ala Pro Glu Met Asn Phe Leu Pro Ser Ala Ala Asn Asn Glu Phe 
    370                 375                 380                 


Ile Tyr Leu Val Gly Leu Glu Glu Val Val Gln Asn Leu Leu Glu Thr 
385                 390                 395                 400 


Gln Ala Gly Arg Met Ser Ala Ala Thr Val Leu Ser Arg Glu Pro Tyr 
                405                 410                 415     


Met Cys Ala Gln Cys Lys Thr Asp Phe Thr Cys Arg Trp Arg Glu Glu 
            420                 425                 430         


Lys Ser Gly Ala Ile Met Cys Glu Asn Cys Met Thr Thr Asn Gln Lys 
        435                 440                 445             


Lys Ala Leu Lys Val Glu His Thr Ser Arg Leu Lys Ala Ala Phe Val 
    450                 455                 460                 


Lys Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Leu Gln Gln 
465                 470                 475                 480 


Gly Thr Ala Pro Ala Gln Ala Lys Ala Glu Pro Thr Ala Ala Pro His 
                485                 490                 495     


Pro Val Leu Lys Gln Val Ile Lys Pro Arg Arg Lys Leu Ala Phe Arg 
            500                 505                 510         


Ser Gly Glu Ala Arg Asp Trp Ser Asn Gly Ala Val Leu Gln Ala Ser 
        515                 520                 525             


Ser Gln Leu Ser Arg Gly Ser Ala Thr Thr Pro Arg Gly Val Leu His 
    530                 535                 540                 


Thr Phe Ser Pro Ser Pro Lys Leu Gln Asn Ser Ala Ser Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ser Arg Thr Gly Arg His Ser Glu Arg Thr Val Ser Ala Gly 
                565                 570                 575     


Lys Gly Ser Ala Thr Ser Asn Trp Lys Lys Thr Pro Leu Ser Thr Gly 
            580                 585                 590         


Gly Thr Leu Ala Phe Val Ser Pro Ser Leu Ala Val His Lys Ser Ser 
        595                 600                 605             


Ser Ala Val Asp Arg Gln Arg Glu Tyr Leu Leu Asp Met Ile Pro Pro 
    610                 615                 620                 


Arg Ser Ile Pro Gln Ser Ala Thr Trp Lys 
625                 630                 


<210>  151
<211>  5386
<212>  DNA
<213>  Homo sapiens

<400>  151
ttcagaatga ccgaagaagc atgccgaaca cggagtcaga aacgagcgct tgaacgggac       60

ccaacagagg acgatgtgga gagcaagaaa ataaaaatgg agagaggatt gttggcttca      120

gatttaaaca ctgacggaga catgagggtg acacctgagc cgggagcagg tccaacccaa      180

ggattgctga gggcaacaga ggccacggcc atggccatgg gcagaggcga agggctggtg      240

ggcgatgggc ccgtggacat gcgcacctca cacagtgaca tgaagtccga gaggagaccc      300

ccctcacctg acgtgattgt gctctccgac aacgagcagc cctcgagccc gagagtgaat      360

gggctgacca cggtggcctt gaaggagact agcaccgagg ccctcatgaa aagcagtcct      420

gaagaacgag aaaggatgat caagcagctg aaggaagaat tgaggttaga agaagcaaaa      480

ctcgtgttgt tgaaaaagtt gcggcagagt caaatacaaa aggaagccac cgcccagaag      540

cccacaggtt ctgttgggag caccgtgacc acccctcccc cgcttgttcg gggcactcag      600

aacattcctg ctggcaagcc atcactccag acctcttcag ctcggatgcc cggcagtgtc      660

atacccccgc ccctggtccg aggtgggcag caggcgtcct cgaagctggg gccacaggcg      720

agctcacagg tcgtcatgcc cccactcgtc aggggggctc agcaaatcca cagcattagg      780

caacattcca gcacagggcc accgcccctc ctcctggccc cccgggcgtc ggtgcccagt      840

gtgcagattc agggacagag gatcatccag cagggcctca tccgcgtcgc caatgttccc      900

aacaccagcc tgctcgtcaa catcccacag cccaccccag catcactgaa ggggacaaca      960

gccacctccg ctcaggccaa ctccaccccc actagtgtgg cctctgtggt cacctctgcc     1020

gagtctccag caagccgaca ggcggccgcc aagctggcgc tgcgcaaaca gctggagaag     1080

acgctactcg agatcccccc acccaagccc ccagccccag agatgaactt cctgcccagc     1140

gccgccaaca acgagttcat ctacctggtc ggcctggagg aggtggtgca gaacctactg     1200

gagacacaag caggcaggat gtcggccgcc actgtgctgt cccgggagcc ctacatgtgt     1260

gcacagtgca agacggactt cacgtgccgc tggcgggagg agaagagcgg cgccatcatg     1320

tgtgagaact gcatgacaac caaccagaag aaggcgctca aggtggagca caccagccgg     1380

ctgaaggccg cctttgtgaa ggcgctgcag caggaacagg agattgagca gcggctcctg     1440

cagcagggca cggcccctgc acaggccaag gccgagccca ccgctgcccc acaccccgtg     1500

ctgaagcagg tcataaaacc ccggcgtaag ttggcgttcc gctcaggaga ggcccgcgac     1560

tggagtaacg gggctgtgct acaggcctcc agccagctgt cccggggttc ggccacgacg     1620

ccccgaggtg tcctgcacac gttcagtccg tcacccaaac tgcagaactc agcctcggcc     1680

acagccctgg tcagcaggac cggcagacat tctgagagaa ccgtgagcgc cggcaagggc     1740

agcgccacct ccaactggaa gaagacgccc ctcagcacag gcgggaccct tgcgtttgtc     1800

agcccaagcc tggcggtgca caagagctcc tcggccgtgg accgccagcg agagtacctc     1860

ctggacatga tcccaccccg ctccatcccc cagtcagcca cgtggaaata gtgcgagcca     1920

ggccccgtgg aagacgggct ccctcctccc ccacctggcc cctggtctag aaggacccac     1980

tgcaccaccc tccgctggct cgggaagaca ccgtgcccgc cccaagagca agcaccggcc     2040

atgctgcaga ggcaagacct caattcttgg ctgcaaagtt tcatcagggc tagggggctg     2100

gtgccgcctc ataggcagac gaggatcatc gctgggggac ctttcccgtg ggctttcttc     2160

ctttctctct ttgcctttag tttgcccgac accagcagaa aagtggacct tgggggctgg     2220

ttctgctcct ggcccccttg ttcagcccct gccggcacac gggcggctca ccctggacac     2280

tgtgatgcgc atgggcaagg ccagcgcccg gggcttctga accgagcggg gtgtttcatt     2340

tttttgcttt tccctgtctt aggctcccag tctttgactg ccttcccatg gcgatctata     2400

agttgaaaga tttttttttt ttttaatcac ctcatgatga tggagttaaa agtaaaccgt     2460

gcagaccctg gggtccctgt tgtacgctgc atcatcccgc tggccctgtg ccctggaggg     2520

tgggcggctc atggtgccac agcccctggc agggacggcc ggcccgcccc cgtgactgac     2580

tgacagatgc agggatggcc gaggcagccc tcgctccagc tgaacgcctc cattgctgct     2640

tgttctggag acccccgccc ccgcaccttc cagacttagc agaagaacaa actgaagaac     2700

agacccagcc agagaagcag ggattccaga agctgcccat taagggagaa ggagaggatc     2760

cggtcggcag cagccctgag cagaaagctg gaggggggac tgtcgcgggg tttttctgtt     2820

gtggtttatt ttattaaatt ttttcctttt ttctattcat ttcgatggac gcaatcttaa     2880

gccaccctgg ccttgctcct gggaggtgag cgtgcacagg tgtgtgcagg tcaggaggtg     2940

ccgtccaggt gtgcggcgag ccgctgcgca cagatgtcag gatttccgtt tgggtctagt     3000

ttagaacctg tccttaaacc taggggttgc tgtcaggatt tgctttcaga cttttttttt     3060

ttttgtaatt ccctttagag tctacaaaaa tgtttttaaa aggatcaggt ctgcttttag     3120

tttcattttt gtttctttcc cgtcccactc tttaaaaact ggttccgtga ggaaaggcag     3180

aagccgttcc gtgtctcttg caggctgggc cggcttcatg ccagtgcgag ggcgtcccgt     3240

gcccacgtac atacgtatgt ctccatgagt tctgggctcc actggttcca attgagctcc     3300

agccctggtt ttcctaccca tgcagttagg gactttaatt taattttttt tttgtagggc     3360

caccgccttc aaacacaact gctacaacat tctaataaag gctcatttaa cccccaggct     3420

cctgtcgtgt gaatatcctc agtctgtagg aaactttttt tgacacagca tagaagacct     3480

agttttggaa aacattatct aattttttgt tgtgcaaatc cccaaatttc tcactaattt     3540

ttgttttttt gtgcataact tggatgggct gaaggaggtg aggacagatt ggggaagggt     3600

ggctttcatt ccaagatcca gggatttggg gaaaaggaag gaatttgatg ttttttgggg     3660

tgggagggga gggtgtgttt tttacaccaa aaaaaaaaaa aaaaatcaag agtatgcaag     3720

catttctatt cctcgcattt ttctgtgtgc ctggcaaata aatacctgtc tcctacgacc     3780

ctgagctgtt agccctctct gttccatgac aggggccaga tcttccagct cctcccagaa     3840

ggagcaccca ggctggcttc ttcccactga aagccctccc cagcgaacca acctcagttc     3900

tatgcagtgg ctggggatca ggcatccaga ccgaagtcac ctctgcctgc tccagcttgg     3960

gtcagctggg tctgaccagg gggccagatc cgagccgcac ctgccggccc ccagccccag     4020

ctccagctcc tgacctctcc cagcctggcc tggctgttcc tccagggctg atggctgtca     4080

acccatcctt gtgagttcat atggactgct gcccctcgaa agggagaggg tcggccccat     4140

gtccccaggg agcattccat cagggacaac gtacatactg tgatgtaaac tttttttttt     4200

tccccccagg gggcaaaagt gtgagatgcc ttaatctttc cttcatttct gctgtctcga     4260

acactctagc ccattatttc ctttcagttc cttgcagcat aacctctacg ataagcccca     4320

agcgggttgt tgtattatga cgtttatgat gttccaggtg aaggcattat taagtacctc     4380

tctgggtgtg gggtttggac gcaccaggat agctattgat taatgttaag ggtgttctac     4440

ccacagcaaa gcacaccctc ttaaaccagg cactgcctgg gtcctggtcc cgagagccct     4500

accaggatca ggttcctgca agccgtcaga atgtgggagc ccccagccca actgattgta     4560

actgtcccct gttacctgtg acatgaacct ccaacagcac ctggaaacgg ttccctctgt     4620

cagctgctct gtagacaggg ctggggagat ctcagagttc acacctcgcc tgttgtaggg     4680

gaggttgggg gtagggtttg gaatggccaa gtgcccttgg aacctcccac agctatggcc     4740

gtcctgacct catcccagga actctacggt gaccaggaac cacccctctg acgaggtctg     4800

tagcggccct tctcagagtg gaacagccca cagtgctagt tgtgcctggt cttacctgta     4860

ctccacggac ctcggtgaag caaaagcttc agggcagagg gaatgaggca acccagtggc     4920

agccccgctg ggccccgtgg ctcctgctct cctattggac gtagaggcag gggagagact     4980

tctctataca aatattctca tcacagaagg gatgatcctt gctgctctgc cgtagggttt     5040

ttgatgctga gctatgctgc acatgacgtt aacctaaaga acttggactg agcttttaaa     5100

aaaggacagc aaacaatttt ataatcctta aagtgtaata gacggttaca ctagtgcagg     5160

gtattgggga ggctctttgg gtgtggaggc tgtcacttgt atttattgtg actctaaatc     5220

tttgatagta aaacaaatgt aaaaagaaat gtttgccacc agatgggaat agaagttcca     5280

ataagcaggc tggaatgggt ggctatacgt tgtatcacga ggaagtttta gactctgaag     5340

gataataaat ggatgatgtg tcaactggaa aaaaaaaaaa aaaaaa                    5386


<210>  152
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Thr Glu Glu Ala Cys Arg Thr Arg Ser Gln Lys Arg Ala Leu Glu 
1               5                   10                  15      


Arg Asp Pro Thr Glu Asp Asp Val Glu Ser Lys Lys Ile Lys Met Glu 
            20                  25                  30          


Arg Gly Leu Leu Ala Ser Asp Leu Asn Thr Asp Gly Asp Met Arg Val 
        35                  40                  45              


Thr Pro Glu Pro Gly Ala Gly Pro Thr Gln Gly Leu Leu Arg Ala Thr 
    50                  55                  60                  


Glu Ala Thr Ala Met Ala Met Gly Arg Gly Glu Gly Leu Val Gly Asp 
65                  70                  75                  80  


Gly Pro Val Asp Met Arg Thr Ser His Ser Asp Met Lys Ser Glu Arg 
                85                  90                  95      


Arg Pro Pro Ser Pro Asp Val Ile Val Leu Ser Asp Asn Glu Gln Pro 
            100                 105                 110         


Ser Ser Pro Arg Val Asn Gly Leu Thr Thr Val Ala Leu Lys Glu Thr 
        115                 120                 125             


Ser Thr Glu Ala Leu Met Lys Ser Ser Pro Glu Glu Arg Glu Arg Met 
    130                 135                 140                 


Ile Lys Gln Leu Lys Glu Glu Leu Arg Leu Glu Glu Ala Lys Leu Val 
145                 150                 155                 160 


Leu Leu Lys Lys Leu Arg Gln Ser Gln Ile Gln Lys Glu Ala Thr Ala 
                165                 170                 175     


Gln Lys Pro Thr Gly Ser Val Gly Ser Thr Val Thr Thr Pro Pro Pro 
            180                 185                 190         


Leu Val Arg Gly Thr Gln Asn Ile Pro Ala Gly Lys Pro Ser Leu Gln 
        195                 200                 205             


Thr Ser Ser Ala Arg Met Pro Gly Ser Val Ile Pro Pro Pro Leu Val 
    210                 215                 220                 


Arg Gly Gly Gln Gln Ala Ser Ser Lys Leu Gly Pro Gln Ala Ser Ser 
225                 230                 235                 240 


Gln Val Val Met Pro Pro Leu Val Arg Gly Ala Gln Gln Ile His Ser 
                245                 250                 255     


Ile Arg Gln His Ser Ser Thr Gly Pro Pro Pro Leu Leu Leu Ala Pro 
            260                 265                 270         


Arg Ala Ser Val Pro Ser Val Gln Ile Gln Gly Gln Arg Ile Ile Gln 
        275                 280                 285             


Gln Gly Leu Ile Arg Val Ala Asn Val Pro Asn Thr Ser Leu Leu Val 
    290                 295                 300                 


Asn Ile Pro Gln Pro Thr Pro Ala Ser Leu Lys Gly Thr Thr Ala Thr 
305                 310                 315                 320 


Ser Ala Gln Ala Asn Ser Thr Pro Thr Ser Val Ala Ser Val Val Thr 
                325                 330                 335     


Ser Ala Glu Ser Pro Ala Ser Arg Gln Ala Ala Ala Lys Leu Ala Leu 
            340                 345                 350         


Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro Pro Pro Lys Pro 
        355                 360                 365             


Pro Ala Pro Glu Met Asn Phe Leu Pro Ser Ala Ala Asn Asn Glu Phe 
    370                 375                 380                 


Ile Tyr Leu Val Gly Leu Glu Glu Val Val Gln Asn Leu Leu Glu Thr 
385                 390                 395                 400 


Gln Gly Arg Met Ser Ala Ala Thr Val Leu Ser Arg Glu Pro Tyr Met 
                405                 410                 415     


Cys Ala Gln Cys Lys Thr Asp Phe Thr Cys Arg Trp Arg Glu Glu Lys 
            420                 425                 430         


Ser Gly Ala Ile Met Cys Glu Asn Cys Met Thr Thr Asn Gln Lys Lys 
        435                 440                 445             


Ala Leu Lys Val Glu His Thr Ser Arg Leu Lys Ala Ala Phe Val Lys 
    450                 455                 460                 


Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Leu Gln Gln Gly 
465                 470                 475                 480 


Thr Ala Pro Ala Gln Ala Lys Ala Glu Pro Thr Ala Ala Pro His Pro 
                485                 490                 495     


Val Leu Lys Gln Val Ile Lys Pro Arg Arg Lys Leu Ala Phe Arg Ser 
            500                 505                 510         


Gly Glu Ala Arg Asp Trp Ser Asn Gly Ala Val Leu Gln Ala Ser Ser 
        515                 520                 525             


Gln Leu Ser Arg Gly Ser Ala Thr Thr Pro Arg Gly Val Leu His Thr 
    530                 535                 540                 


Phe Ser Pro Ser Pro Lys Leu Gln Asn Ser Ala Ser Ala Thr Ala Leu 
545                 550                 555                 560 


Val Ser Arg Thr Gly Arg His Ser Glu Arg Thr Val Ser Ala Gly Lys 
                565                 570                 575     


Gly Ser Ala Thr Ser Asn Trp Lys Lys Thr Pro Leu Ser Thr Gly Gly 
            580                 585                 590         


Thr Leu Ala Phe Val Ser Pro Ser Leu Ala Val His Lys Ser Ser Ser 
        595                 600                 605             


Ala Val Asp Arg Gln Arg Glu Tyr Leu Leu Asp Met Ile Pro Pro Arg 
    610                 615                 620                 


Ser Ile Pro Gln Ser Ala Thr Trp Lys 
625                 630             


<210>  153
<211>  5689
<212>  DNA
<213>  Homo sapiens

<400>  153
gggcaatttc agtgtgagac tgagccgcga gactgagctg cggctccgag cgctgcgcgg       60

cggctcctcc cgcccagggt cagcgccccg gcgcgcgcac gcgcaccccc gccgcccgag      120

cgcgccccgc gccgcccgcg cagtcggtcg gtcggtcgtc tgtcctgtcg ccgctgccgc      180

cgccgccaca gcggccgccg cgggcgccac ctgagggagt cgcctccgcg ggacgccaca      240

agacctgacc ggactgcgcc gcccgaggcc gtcggccgcc gtcagcgagg gcgccgagca      300

acttcgttca gaatgaccga agaagcatgc cgaacacgga gtcagaaacg agcgcttgaa      360

cgggacccaa cagaggacga tgtggagagc aagaaaataa aaatggagag aggattgttg      420

gcttcagatt taaacactga cggagacatg agggtgacac ctgagccggg agcaggtcca      480

acccaaggat tgctgagggc aacagaggcc acggccatgg ccatgggcag aggcgaaggg      540

ctggtgggcg atgggcccgt ggacatgcgc acctcacaca gtgacatgaa gtccgagagg      600

agacccccct cacctgacgt gattgtgctc tccgacaacg agcagccctc gagcccgaga      660

gtgaatgggc tgaccacggt ggccttgaag gagactagca ccgaggccct catgaaaagc      720

agtcctgaag aacgagaaag gatgatcaag cagctgaagg aagaattgag gttagaagaa      780

gcaaaactcg tgttgttgaa aaagttgcgg cagagtcaaa tacaaaagga agccaccgcc      840

cagaagccca caggttctgt tgggagcacc gtgaccaccc ctcccccgct tgttcggggc      900

actcagaaca ttcctgctgg caagccatca ctccagacct cttcagctcg gatgcccggc      960

agtgtcatac ccccgcccct ggtccgaggt gggcagcagg cgtcctcgaa gctggggcca     1020

caggcgagct cacaggtcgt catgccccca ctcgtcaggg gggctcagca aatccacagc     1080

attaggcaac attccagcac agggccaccg cccctcctcc tggccccccg ggcgtcggtg     1140

cccagtgtgc agattcaggg acagaggatc atccagcagg gcctcatccg cgtcgccaat     1200

gttcccaaca ccagcctgct cgtcaacatc ccacagccca ccccagcatc actgaagggg     1260

acaacagcca cctccgctca ggccaactcc acccccacta gtgtggcctc tgtggtcacc     1320

tctgccgagt ctccagcaag ccgacaggcg gccgccaagc tggcgctgcg caaacagctg     1380

gagaagacgc tactcgagat ccccccaccc aagcccccag ccccagagat gaacttcctg     1440

cccagcgccg ccaacaacga gttcatctac ctggtcggcc tggaggaggt ggtgcagaac     1500

ctactggaga cacaaggcag gatgtcggcc gccactgtgc tgtcccggga gccctacatg     1560

tgtgcacagt gcaagacgga cttcacgtgc cgctggcggg aggagaagag cggcgccatc     1620

atgtgtgaga actgcatgac aaccaaccag aagaaggcgc tcaaggtgga gcacaccagc     1680

cggctgaagg ccgcctttgt gaaggcgctg cagcaggaac aggagattga gcagcggctc     1740

ctgcagcagg gcacggcccc tgcacaggcc aaggccgagc ccaccgctgc cccacacccc     1800

gtgctgaagc aggtcataaa accccggcgt aagttggcgt tccgctcagg agaggcccgc     1860

gactggagta acggggctgt gctacaggcc tccagccagc tgtcccgggg ttcggccacg     1920

acgccccgag gtgtcctgca cacgttcagt ccgtcaccca aactgcagaa ctcagcctcg     1980

gccacagccc tggtcagcag gaccggcaga cattctgaga gaaccgtgag cgccggcaag     2040

ggcagcgcca cctccaactg gaagaagacg cccctcagca caggcgggac ccttgcgttt     2100

gtcagcccaa gcctggcggt gcacaagagc tcctcggccg tggaccgcca gcgagagtac     2160

ctcctggaca tgatcccacc ccgctccatc ccccagtcag ccacgtggaa atagtgcgag     2220

ccaggccccg tggaagacgg gctccctcct cccccacctg gcccctggtc tagaaggacc     2280

cactgcacca ccctccgctg gctcgggaag acaccgtgcc cgccccaaga gcaagcaccg     2340

gccatgctgc agaggcaaga cctcaattct tggctgcaaa gtttcatcag ggctaggggg     2400

ctggtgccgc ctcataggca gacgaggatc atcgctgggg gacctttccc gtgggctttc     2460

ttcctttctc tctttgcctt tagtttgccc gacaccagca gaaaagtgga ccttgggggc     2520

tggttctgct cctggccccc ttgttcagcc cctgccggca cacgggcggc tcaccctgga     2580

cactgtgatg cgcatgggca aggccagcgc ccggggcttc tgaaccgagc ggggtgtttc     2640

atttttttgc ttttccctgt cttaggctcc cagtctttga ctgccttccc atggcgatct     2700

ataagttgaa agattttttt tttttttaat cacctcatga tgatggagtt aaaagtaaac     2760

cgtgcagacc ctggggtccc tgttgtacgc tgcatcatcc cgctggccct gtgccctgga     2820

gggtgggcgg ctcatggtgc cacagcccct ggcagggacg gccggcccgc ccccgtgact     2880

gactgacaga tgcagggatg gccgaggcag ccctcgctcc agctgaacgc ctccattgct     2940

gcttgttctg gagacccccg cccccgcacc ttccagactt agcagaagaa caaactgaag     3000

aacagaccca gccagagaag cagggattcc agaagctgcc cattaaggga gaaggagagg     3060

atccggtcgg cagcagccct gagcagaaag ctggaggggg gactgtcgcg gggtttttct     3120

gttgtggttt attttattaa attttttcct tttttctatt catttcgatg gacgcaatct     3180

taagccaccc tggccttgct cctgggaggt gagcgtgcac aggtgtgtgc aggtcaggag     3240

gtgccgtcca ggtgtgcggc gagccgctgc gcacagatgt caggatttcc gtttgggtct     3300

agtttagaac ctgtccttaa acctaggggt tgctgtcagg atttgctttc agactttttt     3360

tttttttgta attcccttta gagtctacaa aaatgttttt aaaaggatca ggtctgcttt     3420

tagtttcatt tttgtttctt tcccgtccca ctctttaaaa actggttccg tgaggaaagg     3480

cagaagccgt tccgtgtctc ttgcaggctg ggccggcttc atgccagtgc gagggcgtcc     3540

cgtgcccacg tacatacgta tgtctccatg agttctgggc tccactggtt ccaattgagc     3600

tccagccctg gttttcctac ccatgcagtt agggacttta atttaatttt ttttttgtag     3660

ggccaccgcc ttcaaacaca actgctacaa cattctaata aaggctcatt taacccccag     3720

gctcctgtcg tgtgaatatc ctcagtctgt aggaaacttt ttttgacaca gcatagaaga     3780

cctagttttg gaaaacatta tctaattttt tgttgtgcaa atccccaaat ttctcactaa     3840

tttttgtttt tttgtgcata acttggatgg gctgaaggag gtgaggacag attggggaag     3900

ggtggctttc attccaagat ccagggattt ggggaaaagg aaggaatttg atgttttttg     3960

gggtgggagg ggagggtgtg ttttttacac caaaaaaaaa aaaaaaaatc aagagtatgc     4020

aagcatttct attcctcgca tttttctgtg tgcctggcaa ataaatacct gtctcctacg     4080

accctgagct gttagccctc tctgttccat gacaggggcc agatcttcca gctcctccca     4140

gaaggagcac ccaggctggc ttcttcccac tgaaagccct ccccagcgaa ccaacctcag     4200

ttctatgcag tggctgggga tcaggcatcc agaccgaagt cacctctgcc tgctccagct     4260

tgggtcagct gggtctgacc agggggccag atccgagccg cacctgccgg cccccagccc     4320

cagctccagc tcctgacctc tcccagcctg gcctggctgt tcctccaggg ctgatggctg     4380

tcaacccatc cttgtgagtt catatggact gctgcccctc gaaagggaga gggtcggccc     4440

catgtcccca gggagcattc catcagggac aacgtacata ctgtgatgta aacttttttt     4500

ttttcccccc agggggcaaa agtgtgagat gccttaatct ttccttcatt tctgctgtct     4560

cgaacactct agcccattat ttcctttcag ttccttgcag cataacctct acgataagcc     4620

ccaagcgggt tgttgtatta tgacgtttat gatgttccag gtgaaggcat tattaagtac     4680

ctctctgggt gtggggtttg gacgcaccag gatagctatt gattaatgtt aagggtgttc     4740

tacccacagc aaagcacacc ctcttaaacc aggcactgcc tgggtcctgg tcccgagagc     4800

cctaccagga tcaggttcct gcaagccgtc agaatgtggg agcccccagc ccaactgatt     4860

gtaactgtcc cctgttacct gtgacatgaa cctccaacag cacctggaaa cggttccctc     4920

tgtcagctgc tctgtagaca gggctgggga gatctcagag ttcacacctc gcctgttgta     4980

ggggaggttg ggggtagggt ttggaatggc caagtgccct tggaacctcc cacagctatg     5040

gccgtcctga cctcatccca ggaactctac ggtgaccagg aaccacccct ctgacgaggt     5100

ctgtagcggc ccttctcaga gtggaacagc ccacagtgct agttgtgcct ggtcttacct     5160

gtactccacg gacctcggtg aagcaaaagc ttcagggcag agggaatgag gcaacccagt     5220

ggcagccccg ctgggccccg tggctcctgc tctcctattg gacgtagagg caggggagag     5280

acttctctat acaaatattc tcatcacaga agggatgatc cttgctgctc tgccgtaggg     5340

tttttgatgc tgagctatgc tgcacatgac gttaacctaa agaacttgga ctgagctttt     5400

aaaaaaggac agcaaacaat tttataatcc ttaaagtgta atagacggtt acactagtgc     5460

agggtattgg ggaggctctt tgggtgtgga ggctgtcact tgtatttatt gtgactctaa     5520

atctttgata gtaaaacaaa tgtaaaaaga aatgtttgcc accagatggg aatagaagtt     5580

ccaataagca ggctggaatg ggtggctata cgttgtatca cgaggaagtt ttagactctg     5640

aaggataata aatggatgat gtgtcaactg gaaaaaaaaa aaaaaaaaa                 5689


<210>  154
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Tyr Gly Arg Pro Gln Ala Glu Met Glu Gln Glu Ala Gly Glu Leu 
1               5                   10                  15      


Ser Arg Trp Gln Ala Ala His Gln Ala Ala Gln Asp Asn Glu Asn Ser 
            20                  25                  30          


Ala Pro Ile Leu Asn Met Ser Ser Ser Ser Gly Ser Ser Gly Val His 
        35                  40                  45              


Thr Ser Trp Asn Gln Gly Leu Pro Ser Ile Gln His Phe Pro His Ser 
    50                  55                  60                  


Ala Glu Met Leu Gly Ser Pro Leu Val Ser Val Glu Ala Pro Gly Gln 
65                  70                  75                  80  


Asn Val Asn Glu Gly Gly Pro Gln Phe Ser Met Pro Leu Pro Glu Arg 
                85                  90                  95      


Gly Met Ser Tyr Cys Pro Gln Ala Thr Leu Thr Pro Ser Arg Met Ile 
            100                 105                 110         


Tyr Cys Gln Arg Met Ser Pro Pro Gln Gln Glu Met Thr Ile Phe Ser 
        115                 120                 125             


Gly Pro Gln Leu Met Pro Val Gly Glu Pro Asn Ile Pro Arg Val Ala 
    130                 135                 140                 


Arg Pro Phe Gly Gly Asn Leu Arg Met Pro Pro Asn Gly Leu Pro Val 
145                 150                 155                 160 


Ser Ala Ser Thr Gly Ile Pro Ile Met Ser His Thr Gly Asn Pro Pro 
                165                 170                 175     


Val Pro Tyr Pro Gly Leu Ser Thr Val Pro Ser Asp Glu Thr Leu Leu 
            180                 185                 190         


Gly Pro Thr Val Pro Ser Thr Glu Ala Gln Ala Val Leu Pro Ser Met 
        195                 200                 205             


Ala Gln Met Leu Pro Pro Gln Asp Ala His Asp Leu Gly Met Pro Pro 
    210                 215                 220                 


Ala Glu Ser Gln Ser Leu Leu Val Leu Gly Ser Gln Asp Ser Leu Val 
225                 230                 235                 240 


Ser Gln Pro Asp Ser Gln Glu Gly Pro Phe Leu Pro Glu Gln Pro Gly 
                245                 250                 255     


Pro Ala Pro Gln Thr Val Glu Lys Asn Ser Arg Pro Gln Glu Gly Thr 
            260                 265                 270         


Gly Arg Arg Gly Ser Ser Glu Ala Arg Pro Tyr Cys Cys Asn Tyr Glu 
        275                 280                 285             


Asn Cys Gly Lys Ala Tyr Thr Lys Arg Ser His Leu Val Ser His Gln 
    290                 295                 300                 


Arg Lys His Thr Gly Glu Arg Pro Tyr Ser Cys Asn Trp Glu Ser Cys 
305                 310                 315                 320 


Ser Trp Ser Phe Phe Arg Ser Asp Glu Leu Arg Arg His Met Arg Val 
                325                 330                 335     


His Thr Arg Tyr Arg Pro Tyr Lys Cys Asp Gln Cys Ser Arg Glu Phe 
            340                 345                 350         


Met Arg Ser Asp His Leu Lys Gln His Gln Lys Thr His Arg Pro Gly 
        355                 360                 365             


Pro Ser Asp Pro Gln Ala Asn Asn Asn Asn Gly Glu Gln Asp Ser Pro 
    370                 375                 380                 


Pro Ala Ala Gly Pro 
385                 


<210>  155
<211>  3131
<212>  DNA
<213>  Homo sapiens

<400>  155
gccgtggtgg ctggttccct gtctcttcag tagagagtct agaccccacc cagtcttcat       60

gtacggccga ccgcaggctg agatggaaca ggaggctggg gagctgagcc ggtggcaggc      120

ggcgcaccag gctgcccagg ataacgagaa ctcagcgccc atcttgaaca tgtcttcatc      180

ttctggaagc tctggagtgc acacctcttg gaaccaaggc ctaccaagca ttcagcactt      240

tcctcacagc gcagagatgc tggggtcccc tttggtgtct gttgaggcgc cggggcagaa      300

tgtgaatgaa ggggggccac agttcagtat gccactgcct gagcgtggta tgagctactg      360

cccccaagcg actctcactc cttcccggat gatttactgt cagagaatgt ctccccctca      420

gcaagagatg acgattttca gtgggcccca actaatgccc gtaggagagc ccaatattcc      480

aagggtagcc aggcccttcg gtgggaatct aaggatgccc cccaatgggc tgccagtctc      540

ggcttccact ggaatcccaa taatgtccca cactgggaac cctccagtgc cttaccctgg      600

cctctcgaca gtaccttctg acgaaacatt gttgggcccg actgtgcctt ccactgaggc      660

ccaggcagtg ctcccctcca tggctcagat gttgcccccg caagatgccc atgaccttgg      720

gatgccccca gctgagtccc agtcattgct ggttttagga tctcaggact ctcttgtcag      780

tcagccagac tctcaagaag gcccatttct accagagcag cccggacctg ctccacagac      840

agtagagaag aactccaggc ctcaggaagg gactggtaga aggggctcct cagaggcaag      900

gccttactgc tgcaactacg agaactgcgg aaaagcttat accaaacgct cccacctcgt      960

gagccaccag cgcaagcaca caggtgagag gccatattct tgcaactggg aaagttgttc     1020

atggtctttc ttccgttctg atgagcttag acgacatatg cgggtacaca ccagatatcg     1080

accatataaa tgtgatcagt gcagccggga gttcatgagg tctgaccatc tcaagcaaca     1140

ccagaagact catcggccgg gaccctcaga cccacaggcc aacaacaaca atggagagca     1200

ggacagtcct cctgctgctg gtccttaggt gaatgaagaa ggaagaggat tccaggctga     1260

gagcactgga cgtggcaact gttcagagga gaggcagtct tcaagttcta cattcattca     1320

gaaaaatgtt ttttgagcct acaatactga gcgcaacaag gctgtggaga cccatggtga     1380

ggagcatgga gttaactaaa ggatgtgtca gggaagaaag acttctcaag gaggtgcctc     1440

catcagaccc aaaggactca tgggggctag ctgcacctca catttcttgg acatataccg     1500

ttggacatgt ctatcttctg gaaactatgg catggacagt aaggattcag aagtgcatga     1560

aggcaccctg cctctgcaga gcagaaagat catagacaac atttatgaat gtgcccagtg     1620

ctgccaagaa gagaagccgg tcctctgcag gctcaagcct atctgggcct ctggggaagc     1680

cccacagcct tggctgtgcc tgcccctgcc ctctcacccc taccctgacc ttgtcctact     1740

tcactgcctt tgtctgtgtt actagtggcc ccagtatacc tgggatggac atccaggtgc     1800

ccttcatcca agctcctatg tgaggggaat ggacattatt aaaagaacag gggcagaagt     1860

ggctcattta tgacccattc actagcccca gggattgaag tcttgggtac tcaaagtgtc     1920

tttctaccag ggcaccagat cccttccatg gagcaggtca tctcgggttc actgggccag     1980

ggatggtctc tgttccccag cccacctggc tcacacacag cctcatgggt agggtcagca     2040

aaccagatgg cttgttgttg gaatgtagga tgagaggcct gcttggtgac ctagcatttt     2100

caccaagaag tggacgtgga gaggaccaga gtgatcaagg gtgtatgatg tgcactacaa     2160

tggtgggcaa aacaggctcc tgctcttgtg gaggtcacaa tctagcggag aaaggatgtt     2220

actagaagta cacaaattgg gcccggcgcg atggctcacg cctgtaatcc cagcactttt     2280

ggaggccgag gcaggcggat catttgaggt tagagattcg agaccagccg ggccaacatg     2340

gtgaaacccc atctctacaa aaaatacaaa aattagcctg gcatatggcg ggtaccgtaa     2400

tcctagctac tcgggagact gacgggagaa tcgcttgaac ccaggaggcg gaggttgcag     2460

tgagctcaga tctcaccatt gcactccagc ctgggcgact gagcgagact ctatctcaaa     2520

acaatcaaaa caaaaaagac ctgtggactc tagtagattt tgaatcctgc ctctgccatt     2580

tcctggctat gaggtgtctt gagaaattta cttgtcactc ttgcttctga tagtaaaggg     2640

gatggtgcga tagattcaag atggagagat aaggttaagt gttttctttg gctgcaacat     2700

ggagattaga ttagagcaag gatgtaaggg agaggaaggg acatagcagt atttcaggtg     2760

agagtcaagg tggctttggc tagggtgtga gagtggaggt agggagaagt aggaaagtga     2820

tagttaactg gatttgttag gtgagggtga ggccaagggt gacttccagg ttcctgactt     2880

gtgttataag taacacagaa gaagaatgga tgaacttgat tcgttttcca ttgattgtga     2940

tatctatcat acctgcaaaa aatattttgt atatatccaa tttaataata aatgcactca     3000

tgttaggaag gtcaaaaaaa aggaaaaaag aaaaataata aaaaataata aaaatcctta     3060

ggataacttg aggccaggag tttgagacca gtgtgacctt gtctctgtaa aaaataaaat     3120

taaaagaaaa a                                                          3131


<210>  156
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  157
<211>  5460
<212>  DNA
<213>  Homo sapiens

<400>  157
gggcttcgct cgccgcctcg cgccgagact agaagcgctg cgggaagcag ggacagtgga       60

gagggcgctg cgctcgggct acccaatgcg tggactatct gccgccgctg ttcgtgcaat      120

atgctggagc tccagaacag ctaaacggag tcgccacacc actgtttgtg ctggatcgca      180

gcgctgcctt tccttatgaa gaagacacaa acttggattc tcacttgcat ttatcttcag      240

ctgctcctat ttaatcctct cgtcaaaact gaagggatct gcaggaatcg tgtgactaat      300

aatgtaaaag acgtcactaa attggtggca aatcttccaa aagactacat gataaccctc      360

aaatatgtcc ccgggatgga tgttttgcca agtcattgtt ggataagcga gatggtagta      420

caattgtcag acagcttgac tgatcttctg gacaagtttt caaatatttc tgaaggcttg      480

agtaattatt ccatcataga caaacttgtg aatatagtgg atgaccttgt ggagtgcgtg      540

aaagaaaact catctaagga tctaaaaaaa tcattcaaga gcccagaacc caggctcttt      600

actcctgaag aattctttag aatttttaat agatccattg atgccttcaa ggactttgta      660

gtggcatctg aaactagtga ttgtgtggtt tcttcaacat taagtcctga gaaagattcc      720

agagtcagtg tcacaaaacc atttatgtta ccccctgttg cagccagctc ccttaggaat      780

gacagcagta gcagtaatag gaaggccaaa aatccccctg gagactccag cctacactgg      840

gcagccatgg cattgccagc attgttttct cttataattg gctttgcttt tggagcctta      900

tactggaaga agagacagcc aagtcttaca agggcagttg aaaatataca aattaatgaa      960

gaggataatg agataagtat gttgcaagag aaagagagag agtttcaaga agtgtaattg     1020

tggcttgtat caacactgtt actttcgtac attggctggt aacagttcat gtttgcttca     1080

taaatgaagc agctttaaac aaattcatat tctgtctgga gtgacagacc acatctttat     1140

ctgttcttgc tacccatgac tttatatgga tgattcagaa attggaacag aatgttttac     1200

tgtgaaactg gcactgaatt aatcatctat aaagaagaac ttgcatggag caggactcta     1260

ttttaaggac tgcgggactt gggtctcatt tagaacttgc agctgatgtt ggaagagaaa     1320

gcacgtgtct cagactgcat gtaccatttg catggctcca gaaatgtcta aatgctgaaa     1380

aaacacctag ctttattctt cagatacaaa ctgcagcctg tagttatcct ggtctctgca     1440

agtagatttc agcttggata gtgagggtaa caatttttct caaagggatc tggaaaaaat     1500

gtttaaaact cagtagtgtc agccactgta cagtgtagaa agcagtggga actgtgattg     1560

gatttggcaa catgtcagct ttatagttgc cgattagtga tatgggtctg atttcgatct     1620

cttcctgatg taaaccatgc tcacccatat cccactatac aaatgcaaat ggttgcctgg     1680

ttccatttat gcaagggagc cagtactgaa ttatgccttg gcagagggga gactccaaaa     1740

gagtcatcgc aggaagaagt taagaacact gaacatcaga acagtctgcc aagaaggaca     1800

ttggcatcct gggaaagtcc gccttttccc ttgaccacta tagggtgtat aaatcgtgtt     1860

tgcaaaatgt gttatgatgt gtttatattc taaaactatt acagagctat gtaaagggac     1920

ttaggagaaa atgctgaatg taagatggtc ccatttcaat ttccaccatg ggagagccta     1980

aaaataaatt atgacattta gtatctaagg ttagaaaacc acgcccacat gctaatatgg     2040

gtgttgaaaa ctaggttact tataatgcaa ggaatcagga aactttagtt atttatagta     2100

taatcaccat tatctgttta aaggatccat ttagttaaaa tcgggcactc tatattcatt     2160

aaggtttatg aattaaaaag aaagctttat gtagttatgc atgtcagttt gctatttaaa     2220

atgtgtgaca gtgtttgtca tattaagagt gaatttggca ggaattccca agatggacat     2280

tgtgctttta aactagaact tgtaagacat tatgtgaata tcccttgcca atttttttta     2340

taataagaaa acatctgact aaagtcaaag aatgatttct tatggtttat tttgatgaaa     2400

gttcttttaa catgtcttga atgtacacat aaaggaatcc aaagctttcc attctaactt     2460

aatctttgtg ataacattat tgccatgttc tacaaccgta agatgacagt tttcaatgta     2520

gtgacacaaa agggcatgaa aaactaactg ctagctttcc tttcatttca aaagtccaag     2580

aatttctagt atatttggat tttagcttct gttcaaagca aatccagatg caactccagt     2640

aagtggcctt tgctcttttt tgtaccaaag agcccagatg attcctacag tccctttctt     2700

ctctaacatg ctgtggttcc ttaaatatga gtaatttctc taagatataa cccaggtgct     2760

ttgagaagct gcattaaggt gttcaggccc tcagatatca catggtacac ttgattagta     2820

ataaaaccag agatcaattt aaattgctga taggtcctgt ctcagtgtgt ggcattgact     2880

gttttcagga aaatagatac agattaatat gagttatgcg tgtaggttgt gtatagattg     2940

agaagataga tacttctcaa tctagtagtt tgatttattt aaccaatggt ttcagtttgc     3000

ttgagcatat gaaaatcctg cttaatgtgc ttaagagtat aataaatgtg tacttttgtc     3060

ctcaaaccta gtagctgggt tttaacactc atggacatgg tcttaatcaa tggagttaaa     3120

taaacaaatt cagcaagtta ttaaatctga catggtagga gaggggagat gtgtcctgct     3180

tattaaatgt gttggtccat tgaaagttac atggattgcc aatttttaaa acactaaagt     3240

tgaataaaat gcatgaacaa tagaaaaatg ctgaacatta ttttggatgc tagctgcttg     3300

gacattaact gtgttatttc tgctttgaga tgaaaatata tatttatctt tgcttatttt     3360

atcccagatg tgttctgaat atccttcttc ataaatcatg gaaaactcac tgctgagata     3420

gtaaaccatg aaatcgcctt ttcagttggt gccatgtatc tgacagttcc atcttggaag     3480

gtttcaaaat taccttttaa aatgatctca gaagtctgta gattctcaat gatactgaaa     3540

gctttgcacc tctttggtag aaaccaggtc tatttagaaa atggctttat gataaatgtt     3600

gcctcctgag tgataatgaa gtgttcctgg atattgtatt gtaatttaat gtgcttacca     3660

cactgccaca ttttaatgag tcagagaaaa attaattttt cttcaataca ataatagaac     3720

aagtagccta ttctcttaaa aagtatgtga aaagaaaatt atgaaaaaat atgcatacct     3780

aatgaagtat tggttttagt aagaattaaa tacatttcat tgagctttaa agtactttgg     3840

agaaactttg gggcacgttt tcctactcta attcaactaa agttataaat aaagagaaaa     3900

actcattcag aaatcatgga ttttaaaaat attttactgc agccaagttt tcatttcaaa     3960

atgtaatttc agtttggagc ttttaggcat tatgtatatt taaaaaatat attcttcaaa     4020

aatgcatttt ggcatggtgg gatggatgtt gcaaaagata tccggagcct ccagtctgtc     4080

attaactgat atggtaaatc acctctcttc tttgggtctc aattttttat ttatctatat     4140

ggtaaactca gagatcactc cttaggggtg agtcctattg caatatgacc gacaaagaag     4200

acaaaatagc attgaaacta acccatacaa aatatccaac tctggattct gtgaataagt     4260

atcttgacca taaaaagtca ttgctgttct tgtttctaat gtaaatagtg tccattagta     4320

aaagtgaaat tcagtcttaa gtagggtgaa ttggatcacc atttacacaa gagatggctt     4380

tttcctttgc ttgaataaac attttggatc acctccaaag aatgaaaacc agtagtacgt     4440

tttagtcata ttagtcagga tgagaaacta taagatgtgt gtaacatttg gaaatgcacc     4500

aaagtgagcg tttaaatctt ctcattttat tgaaaactaa gagcagaaaa tgtaaaatgc     4560

tcatgaaggt tttgaatgcc aaaagatatt ttagaatcaa tttataaagg ggtaattcat     4620

taattacact ttaaaattgg aaagtgggat aagaaatcta aagtaaacca gcttatcttt     4680

gaaacaatat tattttgaaa ttggctttaa aataaaacca ttcagattga aattctaatt     4740

agctcatttg tggagtttga tcacacaatt cataatgttg ctgctttcca ttaactagtc     4800

ttgaaatgcc tttgtttgta aaaataaaat aatggtactt tcattttata acaaggtgtt     4860

tttttcaaga aataatccat gctaaaatgg atatttgtga tcctgaaatg tttactaagc     4920

attgtaaatt tatttataac tgccatctcc aactacatcc ttatgatgtt tttaacaata     4980

aaattaaaac aactgttaaa ctaaaaacca caccgttttc cagtacttga tctctgagct     5040

acaatactca ctaaatataa ttttccaatc aaaatattct attctatatt ctaagggtta     5100

atatgtgatt atagtgtcca cttgccacca tttttttaaa tcaatggact tgaaaagtat     5160

taatttagat ggatgcgcag atataccctc agttcagtca tagattggag tttgcatata     5220

ataatgtaaa tgtatgtcga cactattcta aatagttcta ttatgactga aatttaatta     5280

aataaaaaag gttgtaaaat gtgatgtgta tgtgtatata ctgtatgtgt actttttaaa     5340

ataggtgtat gtcccaaccc ttttttatac aggtttgaat ttaaaattac atgatatata     5400

catatacttt attgttctaa ataaagaatt ttatgcactc tcaaaaaaaa aaaaaaaaaa     5460


<210>  158
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Gly Lys Ala 
                165                 170                 175     


Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu 
            180                 185                 190         


Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr 
        195                 200                 205             


Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln 
    210                 215                 220                 


Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg 
225                 230                 235                 240 


Glu Phe Gln Glu Val 
                245 


<210>  159
<211>  5376
<212>  DNA
<213>  Homo sapiens

<400>  159
gggcttcgct cgccgcctcg cgccgagact agaagcgctg cgggaagcag ggacagtgga       60

gagggcgctg cgctcgggct acccaatgcg tggactatct gccgccgctg ttcgtgcaat      120

atgctggagc tccagaacag ctaaacggag tcgccacacc actgtttgtg ctggatcgca      180

gcgctgcctt tccttatgaa gaagacacaa acttggattc tcacttgcat ttatcttcag      240

ctgctcctat ttaatcctct cgtcaaaact gaagggatct gcaggaatcg tgtgactaat      300

aatgtaaaag acgtcactaa attggtggca aatcttccaa aagactacat gataaccctc      360

aaatatgtcc ccgggatgga tgttttgcca agtcattgtt ggataagcga gatggtagta      420

caattgtcag acagcttgac tgatcttctg gacaagtttt caaatatttc tgaaggcttg      480

agtaattatt ccatcataga caaacttgtg aatatagtgg atgaccttgt ggagtgcgtg      540

aaagaaaact catctaagga tctaaaaaaa tcattcaaga gcccagaacc caggctcttt      600

actcctgaag aattctttag aatttttaat agatccattg atgccttcaa ggactttgta      660

gtggcatctg aaactagtga ttgtgtggtt tcttcaacat taagtcctga gaaagggaag      720

gccaaaaatc cccctggaga ctccagccta cactgggcag ccatggcatt gccagcattg      780

ttttctctta taattggctt tgcttttgga gccttatact ggaagaagag acagccaagt      840

cttacaaggg cagttgaaaa tatacaaatt aatgaagagg ataatgagat aagtatgttg      900

caagagaaag agagagagtt tcaagaagtg taattgtggc ttgtatcaac actgttactt      960

tcgtacattg gctggtaaca gttcatgttt gcttcataaa tgaagcagct ttaaacaaat     1020

tcatattctg tctggagtga cagaccacat ctttatctgt tcttgctacc catgacttta     1080

tatggatgat tcagaaattg gaacagaatg ttttactgtg aaactggcac tgaattaatc     1140

atctataaag aagaacttgc atggagcagg actctatttt aaggactgcg ggacttgggt     1200

ctcatttaga acttgcagct gatgttggaa gagaaagcac gtgtctcaga ctgcatgtac     1260

catttgcatg gctccagaaa tgtctaaatg ctgaaaaaac acctagcttt attcttcaga     1320

tacaaactgc agcctgtagt tatcctggtc tctgcaagta gatttcagct tggatagtga     1380

gggtaacaat ttttctcaaa gggatctgga aaaaatgttt aaaactcagt agtgtcagcc     1440

actgtacagt gtagaaagca gtgggaactg tgattggatt tggcaacatg tcagctttat     1500

agttgccgat tagtgatatg ggtctgattt cgatctcttc ctgatgtaaa ccatgctcac     1560

ccatatccca ctatacaaat gcaaatggtt gcctggttcc atttatgcaa gggagccagt     1620

actgaattat gccttggcag aggggagact ccaaaagagt catcgcagga agaagttaag     1680

aacactgaac atcagaacag tctgccaaga aggacattgg catcctggga aagtccgcct     1740

tttcccttga ccactatagg gtgtataaat cgtgtttgca aaatgtgtta tgatgtgttt     1800

atattctaaa actattacag agctatgtaa agggacttag gagaaaatgc tgaatgtaag     1860

atggtcccat ttcaatttcc accatgggag agcctaaaaa taaattatga catttagtat     1920

ctaaggttag aaaaccacgc ccacatgcta atatgggtgt tgaaaactag gttacttata     1980

atgcaaggaa tcaggaaact ttagttattt atagtataat caccattatc tgtttaaagg     2040

atccatttag ttaaaatcgg gcactctata ttcattaagg tttatgaatt aaaaagaaag     2100

ctttatgtag ttatgcatgt cagtttgcta tttaaaatgt gtgacagtgt ttgtcatatt     2160

aagagtgaat ttggcaggaa ttcccaagat ggacattgtg cttttaaact agaacttgta     2220

agacattatg tgaatatccc ttgccaattt tttttataat aagaaaacat ctgactaaag     2280

tcaaagaatg atttcttatg gtttattttg atgaaagttc ttttaacatg tcttgaatgt     2340

acacataaag gaatccaaag ctttccattc taacttaatc tttgtgataa cattattgcc     2400

atgttctaca accgtaagat gacagttttc aatgtagtga cacaaaaggg catgaaaaac     2460

taactgctag ctttcctttc atttcaaaag tccaagaatt tctagtatat ttggatttta     2520

gcttctgttc aaagcaaatc cagatgcaac tccagtaagt ggcctttgct cttttttgta     2580

ccaaagagcc cagatgattc ctacagtccc tttcttctct aacatgctgt ggttccttaa     2640

atatgagtaa tttctctaag atataaccca ggtgctttga gaagctgcat taaggtgttc     2700

aggccctcag atatcacatg gtacacttga ttagtaataa aaccagagat caatttaaat     2760

tgctgatagg tcctgtctca gtgtgtggca ttgactgttt tcaggaaaat agatacagat     2820

taatatgagt tatgcgtgta ggttgtgtat agattgagaa gatagatact tctcaatcta     2880

gtagtttgat ttatttaacc aatggtttca gtttgcttga gcatatgaaa atcctgctta     2940

atgtgcttaa gagtataata aatgtgtact tttgtcctca aacctagtag ctgggtttta     3000

acactcatgg acatggtctt aatcaatgga gttaaataaa caaattcagc aagttattaa     3060

atctgacatg gtaggagagg ggagatgtgt cctgcttatt aaatgtgttg gtccattgaa     3120

agttacatgg attgccaatt tttaaaacac taaagttgaa taaaatgcat gaacaataga     3180

aaaatgctga acattatttt ggatgctagc tgcttggaca ttaactgtgt tatttctgct     3240

ttgagatgaa aatatatatt tatctttgct tattttatcc cagatgtgtt ctgaatatcc     3300

ttcttcataa atcatggaaa actcactgct gagatagtaa accatgaaat cgccttttca     3360

gttggtgcca tgtatctgac agttccatct tggaaggttt caaaattacc ttttaaaatg     3420

atctcagaag tctgtagatt ctcaatgata ctgaaagctt tgcacctctt tggtagaaac     3480

caggtctatt tagaaaatgg ctttatgata aatgttgcct cctgagtgat aatgaagtgt     3540

tcctggatat tgtattgtaa tttaatgtgc ttaccacact gccacatttt aatgagtcag     3600

agaaaaatta atttttcttc aatacaataa tagaacaagt agcctattct cttaaaaagt     3660

atgtgaaaag aaaattatga aaaaatatgc atacctaatg aagtattggt tttagtaaga     3720

attaaataca tttcattgag ctttaaagta ctttggagaa actttggggc acgttttcct     3780

actctaattc aactaaagtt ataaataaag agaaaaactc attcagaaat catggatttt     3840

aaaaatattt tactgcagcc aagttttcat ttcaaaatgt aatttcagtt tggagctttt     3900

aggcattatg tatatttaaa aaatatattc ttcaaaaatg cattttggca tggtgggatg     3960

gatgttgcaa aagatatccg gagcctccag tctgtcatta actgatatgg taaatcacct     4020

ctcttctttg ggtctcaatt ttttatttat ctatatggta aactcagaga tcactcctta     4080

ggggtgagtc ctattgcaat atgaccgaca aagaagacaa aatagcattg aaactaaccc     4140

atacaaaata tccaactctg gattctgtga ataagtatct tgaccataaa aagtcattgc     4200

tgttcttgtt tctaatgtaa atagtgtcca ttagtaaaag tgaaattcag tcttaagtag     4260

ggtgaattgg atcaccattt acacaagaga tggctttttc ctttgcttga ataaacattt     4320

tggatcacct ccaaagaatg aaaaccagta gtacgtttta gtcatattag tcaggatgag     4380

aaactataag atgtgtgtaa catttggaaa tgcaccaaag tgagcgttta aatcttctca     4440

ttttattgaa aactaagagc agaaaatgta aaatgctcat gaaggttttg aatgccaaaa     4500

gatattttag aatcaattta taaaggggta attcattaat tacactttaa aattggaaag     4560

tgggataaga aatctaaagt aaaccagctt atctttgaaa caatattatt ttgaaattgg     4620

ctttaaaata aaaccattca gattgaaatt ctaattagct catttgtgga gtttgatcac     4680

acaattcata atgttgctgc tttccattaa ctagtcttga aatgcctttg tttgtaaaaa     4740

taaaataatg gtactttcat tttataacaa ggtgtttttt tcaagaaata atccatgcta     4800

aaatggatat ttgtgatcct gaaatgttta ctaagcattg taaatttatt tataactgcc     4860

atctccaact acatccttat gatgttttta acaataaaat taaaacaact gttaaactaa     4920

aaaccacacc gttttccagt acttgatctc tgagctacaa tactcactaa atataatttt     4980

ccaatcaaaa tattctattc tatattctaa gggttaatat gtgattatag tgtccacttg     5040

ccaccatttt tttaaatcaa tggacttgaa aagtattaat ttagatggat gcgcagatat     5100

accctcagtt cagtcataga ttggagtttg catataataa tgtaaatgta tgtcgacact     5160

attctaaata gttctattat gactgaaatt taattaaata aaaaaggttg taaaatgtga     5220

tgtgtatgtg tatatactgt atgtgtactt tttaaaatag gtgtatgtcc caaccctttt     5280

ttatacaggt ttgaatttaa aattacatga tatatacata tactttattg ttctaaataa     5340

agaattttat gcactctcaa aaaaaaaaaa aaaaaa                               5376


<210>  160
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  161
<211>  7321
<212>  DNA
<213>  Homo sapiens

<400>  161
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240

ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300

tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360

gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420

gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480

cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540

tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600

gacatgccca agacccagaa ggaagtacat ttgaagaacg caagtagagg gagtgcagga      660

aacaagaact acaggatgta ggaagaccct cctgaggagt gaagagtgac atgccaccgc      720

aggatccttt gctctgcacg agttacctgt taaactttgg aacacctacc aaaaaataag      780

tttgataaca tttaaaagat gggcgtttcc cccaatgaaa tacacaagta aacattccaa      840

cattgtcttt aggagtgatt tgcaccttgc aaaaatggtc ctggagttgg tagattgctg      900

ttgatctttt atcaataatg ttctatagaa aagaaaaaaa aaatatatat atatatatat      960

cttagtccct gcctctcaag agccacaaat gcatgggtgt tgtatagatc cagttgcact     1020

aaattcctct ctgaatcttg gctgctggag ccattcattc agcaaccttg tctaagtggt     1080

ttatgaattg tttccttatt tgcacttctt tctacacaac tcgggctgtt tgttttacag     1140

tgtctgataa tcttgttagt ctatacccac cacctccctt cataaccttt atatttgccg     1200

aatttggcct cctcaaaagc agcagcaagt cgtcaagaag cacaccaatt ctaacccaca     1260

agattccatc tgtggcattt gtaccaaata taagttggat gcattttatt ttagacacaa     1320

agctttattt ttccacatca tgcttacaaa aaagaataat gcaaatagtt gcaactttga     1380

ggccaatcat ttttaggcat atgttttaaa catagaaagt ttcttcaact caaaagagtt     1440

ccttcaaatg atgagttaat gtgcaaccta attagtaact ttcctctttt tattttttcc     1500

atatagagca ctatgtaaat ttagcatatc aattatacag gatatatcaa acagtatgta     1560

aaactctgtt ttttagtata atggtgctat tttgtagttt gttatatgaa agagtctggc     1620

caaaacggta atacgtgaaa gcaaaacaat aggggaagcc tggagccaaa gatgacacaa     1680

ggggaagggt actgaaaaca ccatccattt gggaaagaag gcaaagtccc cccagttatg     1740

ccttccaaga ggaacttcag acacaaaagt ccactgatgc aaattggact ggcgagtcca     1800

gagaggaaac tgtggaatgg aaaaagcaga aggctaggaa ttttagcagt cctggtttct     1860

ttttctcatg gaagaaatga acatctgcca gctgtgtcat ggactcacca ctgtgtgacc     1920

ttgggcaagt cacttcacct ctctgtgcct cagtttcctc atctgcaaaa tgggggcaat     1980

atgtcatcta cctacctcaa aggggtggta taaggtttaa aaagataaag attcagattt     2040

tttttaccct gggttgctgt aagggtgcaa catcagggcg cttgagttgc tgagatgcaa     2100

ggaattctat aaataaccca ttcatagcat agctagagat tggtgaattg aatgctcctg     2160

acatctcagt tcttgtcagt gaagctatcc aaataactgg ccaactagtt gttaaaagct     2220

aacagctcaa tctcttaaaa cacttttcaa aatatgtggg aagcatttga ttttcaattt     2280

gattttgaat tctgcatttg gttttatgaa tacaaagata agtgaaaaga gagaaaggaa     2340

aagaaaaagg agaaaaacaa agagatttct accagtgaaa ggggaattaa ttactctttg     2400

ttagcactca ctgactcttc tatgcagtta ctacatatct agtaaaacct cgtttaatac     2460

tataaataat attctattca ttttgaaaaa cacaatgatt ccttcttttc taggcaatat     2520

aaggaaagtg atccaaaatt tgaaatatta aaataatatc taataaaaag tcacaaagtt     2580

atcttcttta acaaacttta ctcttattct tagctgtata tacatttttt taaaagtttg     2640

ttaaaatatg cttgactaga gtttccagtt gaaaggcaaa aacttccatc acaacaagaa     2700

atttcccatg cctgctcaga agggtagccc ctagctctct gtgaatgtgt tttatccatt     2760

caactgaaaa ttggtatcaa gaaagtccac tggttagtgt actagtccat catagcctag     2820

aaaatgatcc ctatctgcag atcaagattt tctcattaga acaatgaatt atccagcatt     2880

cagatctttc tagtcacctt agaacttttt ggttaaaagt acccaggctt gattatttca     2940

tgcaaattct atattttaca ttcttggaaa gtctatatga aaaacaaaaa taacatcttc     3000

agtttttctc ccactgggtc acctcaagga tcagaggcca ggaaaaaaaa aaaaaagact     3060

ccctggatct ctgaatatat gcaaaaagaa ggccccattt agtggagcca gcaatcctgt     3120

tcagtcaaca agtattttaa ctctcagtcc aacattattt gaattgagca cctcaagcat     3180

gcttagcaat gttctaatca ctatggacag atgtaaaaga aactatacat catttttgcc     3240

ctctgcctgt tttccagaca tacaggttct gtggaataag atactggact cctcttccca     3300

agatggcact tctttttatt tcttgtcccc agtgtgtacc ttttaaaatt attccctctc     3360

aacaaaactt tataggcagt cttctgcaga cttaacgtgt tttctgtcat agttagatgt     3420

gataattcta agagtgtcta tgacttattt ccttcactta attctatcca cagtcaaaaa     3480

tcccccaagg aggaaagctg aaagatgcac tgccatatta tctttcttaa ctttttccaa     3540

cacataatcc tctccaactg gattataaat aaattgaaaa taactcatta taccaattca     3600

ctattttatt ttttaatgaa ttaaaactag aaaacaaatt gatgcaaacc ctggaagtca     3660

gttgattact atatactaca gcagaatgac tcagatttca tagaaaggag caaccaaaat     3720

gtcacaaccc aaaactttac aagctttgct tcagaattag attgctttat aattcttgaa     3780

tgaggcaatt tcaagatatt tgtaaaagaa cagtaaacat tggtaagaat gagctttcaa     3840

ctcataggct tatttccaat ttaattgacc atactggata cttaggtcaa atttctgttc     3900

tctcttcccc aaataatatt aaagtattat ttgaactttt taagatgagg cagttcccct     3960

gaaaaagtta atgcagctct ccatcagaat ccactcttct agggatatga aaatctctta     4020

acacccaccc tacatacaca gacacacaca cacacacaca cacacacaca cacacacaca     4080

ttcaccctaa ggatccaatg gaatactgaa aagaaatcac ttccttgaaa attttattaa     4140

aaaacaaaca aacaaacaaa aagcctgtcc acccttgaga atccttcctc tccttggaac     4200

gtcaatgttt gtgtagatga aaccatctca tgctctgtgg ctccagggtt tctgttacta     4260

ttttatgcac ttgggagaag gcttagaata aaagatgtag cacattttgc tttcccattt     4320

attgtttggc cagctatgcc aatgtggtgc tattgtttct ttaagaaagt acttgactaa     4380

aaaaaaaaga aaaaaagaaa aaaaagaaag catagacata tttttttaaa gtataaaaac     4440

aacaattcta tagatagatg gcttaataaa atagcattag gtctatctag ccaccaccac     4500

ctttcaactt tttatcactc acaagtagtg tactgttcac caaattgtga atttgggggt     4560

gcaggggcag gagttggaaa ttttttaaag ttagaaggct ccattgtttt gttggctctc     4620

aaacttagca aaattagcaa tatattatcc aatcttctga acttgatcaa gagcatggag     4680

aataaacgcg ggaaaaaaga tcttataggc aaatagaaga atttaaaaga taagtaagtt     4740

ccttattgat ttttgtgcac tctgctctaa aacagatatt cagcaagtgg agaaaataag     4800

aacaaagaga aaaaatacat agatttacct gcaaaaaata gcttctgcca aatccccctt     4860

gggtattctt tggcatttac tggtttatag aagacattct cccttcaccc agacatctca     4920

aagagcagta gctctcatga aaagcaatca ctgatctcat ttgggaaatg ttggaaagta     4980

tttccttatg agatgggggt tatctactga taaagaaaga atttatgaga aattgttgaa     5040

agagatggct aacaatctgt gaagattttt tgtttcttgt ttttgttttt tttttttttt     5100

tactttatac agtctttatg aatttcttaa tgttcaaaat gacttggttc ttttcttctt     5160

tttttatatc agaatgagga ataataagtt aaacccacat agactcttta aaactatagg     5220

ctagatagaa atgtatgttt gacttgttga agctataatc agactattta aaatgttttg     5280

ctatttttaa tcttaaaaga ttgtgctaat ttattagagc agaacctgtt tggctctcct     5340

cagaagaaag aatctttcca ttcaaatcac atggctttcc accaatattt tcaaaagata     5400

aatctgattt atgcaatggc atcatttatt ttaaaacaga agaattgtga aagtttatgc     5460

ccctcccttg caaagaccat aaagtccaga tctggtaggg gggcaacaac aaaaggaaaa     5520

tgttgttgat tcttggtttt ggattttgtt ttgttttcaa tgctagtgtt taatcctgta     5580

gtacatattt gcttattgct attttaatat tttataagac cttcctgtta ggtattagaa     5640

agtgatacat agatatcttt tttgtgtaat ttctatttaa aaaagagaga agactgtcag     5700

aagctttaag tgcatatggt acaggataaa gatatcaatt taaataacca attcctatct     5760

ggaacaatgc ttttgttttt taaagaaacc tctcacagat aagacagagg cccaggggat     5820

ttttgaagct gtctttattc tgcccccatc ccaacccagc ccttattatt ttagtatctg     5880

cctcagaatt ttatagaggg ctgaccaagc tgaaactcta gaattaaagg aacctcactg     5940

aaaacatata tttcacgtgt tccctctttt tttttttcct ttttgtgaga tggggtctcg     6000

cactgtcccc caggctggag tgcagtggca tgatctcggc tcactgcaac ctccacctcc     6060

tgggtttaag cgattctcct gcctcagcct cctgagtagc tgggattaca ggcacccacc     6120

actatgcccg gctaattttt tggattttta atagagacgg ggttttacca tgttggccag     6180

gttggtctca aactcctgac cttgtgattt gcccgcctca gcctcccaaa ttgctgggat     6240

tacaggcatg agccaccaca ccctgcccat gtgttccctc ttaatgtatg attacatgga     6300

tcttaaacat gatccttctc tcctcattct tcaactatct ttgatggggt ctttcaaggg     6360

gaaaaaaatc caagcttttt taaagtaaaa aaaaaaaaag agaggacaca aaaccaaatg     6420

ttactgctca actgaaatat gagttaagat ggagacagag tttctcctaa taaccggagc     6480

tgaattacct ttcactttca aaaacatgac cttccacaat ccttagaatc tgcctttttt     6540

tatattactg aggcctaaaa gtaaacatta ctcattttat tttgcccaaa atgcactgat     6600

gtaaagtagg aaaaataaaa acagagctct aaaatccctt tcaagccacc cattgacccc     6660

actcaccaac tcatagcaaa gtcacttctg ttaatccctt aatctgattt tgtttggata     6720

tttatcttgt acccgctgct aaacacactg caggagggac tctgaaacct caagctgtct     6780

acttacatct tttatctgtg tctgtgtatc atgaaaatgt ctattcaaaa tatcaaaacc     6840

tttcaaatat cacgcagctt atattcagtt tacataaagg ccccaaatac catgtcagat     6900

ctttttggta aaagagttaa tgaactatga gaattgggat tacatcatgt attttgcctc     6960

atgtattttt atcacactta taggccaagt gtgataaata aacttacaga cactgaatta     7020

atttcccctg ctactttgaa accagaaaat aatgactggc cattcgttac atctgtctta     7080

gttgaaaagc atatttttta ttaaattaat tctgattgta tttgaaatta ttattcaatt     7140

cacttatggc agaggaatat caatcctaat gacttctaaa aatgtaacta attgaatcat     7200

tatcttacat ttactgttta ataagcatat tttgaaaatg tatggctaga gtgtcataat     7260

aaaatggtat atctttcttt agtaattaca ttaaaattag tcatgtttga ttaattagtt     7320

c                                                                     7321


<210>  162
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210>  163
<211>  7370
<212>  DNA
<213>  Homo sapiens

<400>  163
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240

ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300

tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360

gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420

gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480

cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540

tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600

gacatgccca agacccagaa gtatcagccc ccatctacca acaagaacac gaagtctcag      660

agaaggaaag gaagtacatt tgaagaacgc aagtagaggg agtgcaggaa acaagaacta      720

caggatgtag gaagaccctc ctgaggagtg aagagtgaca tgccaccgca ggatcctttg      780

ctctgcacga gttacctgtt aaactttgga acacctacca aaaaataagt ttgataacat      840

ttaaaagatg ggcgtttccc ccaatgaaat acacaagtaa acattccaac attgtcttta      900

ggagtgattt gcaccttgca aaaatggtcc tggagttggt agattgctgt tgatctttta      960

tcaataatgt tctatagaaa agaaaaaaaa aatatatata tatatatatc ttagtccctg     1020

cctctcaaga gccacaaatg catgggtgtt gtatagatcc agttgcacta aattcctctc     1080

tgaatcttgg ctgctggagc cattcattca gcaaccttgt ctaagtggtt tatgaattgt     1140

ttccttattt gcacttcttt ctacacaact cgggctgttt gttttacagt gtctgataat     1200

cttgttagtc tatacccacc acctcccttc ataaccttta tatttgccga atttggcctc     1260

ctcaaaagca gcagcaagtc gtcaagaagc acaccaattc taacccacaa gattccatct     1320

gtggcatttg taccaaatat aagttggatg cattttattt tagacacaaa gctttatttt     1380

tccacatcat gcttacaaaa aagaataatg caaatagttg caactttgag gccaatcatt     1440

tttaggcata tgttttaaac atagaaagtt tcttcaactc aaaagagttc cttcaaatga     1500

tgagttaatg tgcaacctaa ttagtaactt tcctcttttt attttttcca tatagagcac     1560

tatgtaaatt tagcatatca attatacagg atatatcaaa cagtatgtaa aactctgttt     1620

tttagtataa tggtgctatt ttgtagtttg ttatatgaaa gagtctggcc aaaacggtaa     1680

tacgtgaaag caaaacaata ggggaagcct ggagccaaag atgacacaag gggaagggta     1740

ctgaaaacac catccatttg ggaaagaagg caaagtcccc ccagttatgc cttccaagag     1800

gaacttcaga cacaaaagtc cactgatgca aattggactg gcgagtccag agaggaaact     1860

gtggaatgga aaaagcagaa ggctaggaat tttagcagtc ctggtttctt tttctcatgg     1920

aagaaatgaa catctgccag ctgtgtcatg gactcaccac tgtgtgacct tgggcaagtc     1980

acttcacctc tctgtgcctc agtttcctca tctgcaaaat gggggcaata tgtcatctac     2040

ctacctcaaa ggggtggtat aaggtttaaa aagataaaga ttcagatttt ttttaccctg     2100

ggttgctgta agggtgcaac atcagggcgc ttgagttgct gagatgcaag gaattctata     2160

aataacccat tcatagcata gctagagatt ggtgaattga atgctcctga catctcagtt     2220

cttgtcagtg aagctatcca aataactggc caactagttg ttaaaagcta acagctcaat     2280

ctcttaaaac acttttcaaa atatgtggga agcatttgat tttcaatttg attttgaatt     2340

ctgcatttgg ttttatgaat acaaagataa gtgaaaagag agaaaggaaa agaaaaagga     2400

gaaaaacaaa gagatttcta ccagtgaaag gggaattaat tactctttgt tagcactcac     2460

tgactcttct atgcagttac tacatatcta gtaaaacctc gtttaatact ataaataata     2520

ttctattcat tttgaaaaac acaatgattc cttcttttct aggcaatata aggaaagtga     2580

tccaaaattt gaaatattaa aataatatct aataaaaagt cacaaagtta tcttctttaa     2640

caaactttac tcttattctt agctgtatat acattttttt aaaagtttgt taaaatatgc     2700

ttgactagag tttccagttg aaaggcaaaa acttccatca caacaagaaa tttcccatgc     2760

ctgctcagaa gggtagcccc tagctctctg tgaatgtgtt ttatccattc aactgaaaat     2820

tggtatcaag aaagtccact ggttagtgta ctagtccatc atagcctaga aaatgatccc     2880

tatctgcaga tcaagatttt ctcattagaa caatgaatta tccagcattc agatctttct     2940

agtcacctta gaactttttg gttaaaagta cccaggcttg attatttcat gcaaattcta     3000

tattttacat tcttggaaag tctatatgaa aaacaaaaat aacatcttca gtttttctcc     3060

cactgggtca cctcaaggat cagaggccag gaaaaaaaaa aaaaagactc cctggatctc     3120

tgaatatatg caaaaagaag gccccattta gtggagccag caatcctgtt cagtcaacaa     3180

gtattttaac tctcagtcca acattatttg aattgagcac ctcaagcatg cttagcaatg     3240

ttctaatcac tatggacaga tgtaaaagaa actatacatc atttttgccc tctgcctgtt     3300

ttccagacat acaggttctg tggaataaga tactggactc ctcttcccaa gatggcactt     3360

ctttttattt cttgtcccca gtgtgtacct tttaaaatta ttccctctca acaaaacttt     3420

ataggcagtc ttctgcagac ttaacgtgtt ttctgtcata gttagatgtg ataattctaa     3480

gagtgtctat gacttatttc cttcacttaa ttctatccac agtcaaaaat cccccaagga     3540

ggaaagctga aagatgcact gccatattat ctttcttaac tttttccaac acataatcct     3600

ctccaactgg attataaata aattgaaaat aactcattat accaattcac tattttattt     3660

tttaatgaat taaaactaga aaacaaattg atgcaaaccc tggaagtcag ttgattacta     3720

tatactacag cagaatgact cagatttcat agaaaggagc aaccaaaatg tcacaaccca     3780

aaactttaca agctttgctt cagaattaga ttgctttata attcttgaat gaggcaattt     3840

caagatattt gtaaaagaac agtaaacatt ggtaagaatg agctttcaac tcataggctt     3900

atttccaatt taattgacca tactggatac ttaggtcaaa tttctgttct ctcttcccca     3960

aataatatta aagtattatt tgaacttttt aagatgaggc agttcccctg aaaaagttaa     4020

tgcagctctc catcagaatc cactcttcta gggatatgaa aatctcttaa cacccaccct     4080

acatacacag acacacacac acacacacac acacacacac acacacacat tcaccctaag     4140

gatccaatgg aatactgaaa agaaatcact tccttgaaaa ttttattaaa aaacaaacaa     4200

acaaacaaaa agcctgtcca cccttgagaa tccttcctct ccttggaacg tcaatgtttg     4260

tgtagatgaa accatctcat gctctgtggc tccagggttt ctgttactat tttatgcact     4320

tgggagaagg cttagaataa aagatgtagc acattttgct ttcccattta ttgtttggcc     4380

agctatgcca atgtggtgct attgtttctt taagaaagta cttgactaaa aaaaaaagaa     4440

aaaaagaaaa aaaagaaagc atagacatat ttttttaaag tataaaaaca acaattctat     4500

agatagatgg cttaataaaa tagcattagg tctatctagc caccaccacc tttcaacttt     4560

ttatcactca caagtagtgt actgttcacc aaattgtgaa tttgggggtg caggggcagg     4620

agttggaaat tttttaaagt tagaaggctc cattgttttg ttggctctca aacttagcaa     4680

aattagcaat atattatcca atcttctgaa cttgatcaag agcatggaga ataaacgcgg     4740

gaaaaaagat cttataggca aatagaagaa tttaaaagat aagtaagttc cttattgatt     4800

tttgtgcact ctgctctaaa acagatattc agcaagtgga gaaaataaga acaaagagaa     4860

aaaatacata gatttacctg caaaaaatag cttctgccaa atcccccttg ggtattcttt     4920

ggcatttact ggtttataga agacattctc ccttcaccca gacatctcaa agagcagtag     4980

ctctcatgaa aagcaatcac tgatctcatt tgggaaatgt tggaaagtat ttccttatga     5040

gatgggggtt atctactgat aaagaaagaa tttatgagaa attgttgaaa gagatggcta     5100

acaatctgtg aagatttttt gtttcttgtt tttgtttttt tttttttttt actttataca     5160

gtctttatga atttcttaat gttcaaaatg acttggttct tttcttcttt ttttatatca     5220

gaatgaggaa taataagtta aacccacata gactctttaa aactataggc tagatagaaa     5280

tgtatgtttg acttgttgaa gctataatca gactatttaa aatgttttgc tatttttaat     5340

cttaaaagat tgtgctaatt tattagagca gaacctgttt ggctctcctc agaagaaaga     5400

atctttccat tcaaatcaca tggctttcca ccaatatttt caaaagataa atctgattta     5460

tgcaatggca tcatttattt taaaacagaa gaattgtgaa agtttatgcc cctcccttgc     5520

aaagaccata aagtccagat ctggtagggg ggcaacaaca aaaggaaaat gttgttgatt     5580

cttggttttg gattttgttt tgttttcaat gctagtgttt aatcctgtag tacatatttg     5640

cttattgcta ttttaatatt ttataagacc ttcctgttag gtattagaaa gtgatacata     5700

gatatctttt ttgtgtaatt tctatttaaa aaagagagaa gactgtcaga agctttaagt     5760

gcatatggta caggataaag atatcaattt aaataaccaa ttcctatctg gaacaatgct     5820

tttgtttttt aaagaaacct ctcacagata agacagaggc ccaggggatt tttgaagctg     5880

tctttattct gcccccatcc caacccagcc cttattattt tagtatctgc ctcagaattt     5940

tatagagggc tgaccaagct gaaactctag aattaaagga acctcactga aaacatatat     6000

ttcacgtgtt ccctcttttt ttttttcctt tttgtgagat ggggtctcgc actgtccccc     6060

aggctggagt gcagtggcat gatctcggct cactgcaacc tccacctcct gggtttaagc     6120

gattctcctg cctcagcctc ctgagtagct gggattacag gcacccacca ctatgcccgg     6180

ctaatttttt ggatttttaa tagagacggg gttttaccat gttggccagg ttggtctcaa     6240

actcctgacc ttgtgatttg cccgcctcag cctcccaaat tgctgggatt acaggcatga     6300

gccaccacac cctgcccatg tgttccctct taatgtatga ttacatggat cttaaacatg     6360

atccttctct cctcattctt caactatctt tgatggggtc tttcaagggg aaaaaaatcc     6420

aagctttttt aaagtaaaaa aaaaaaaaga gaggacacaa aaccaaatgt tactgctcaa     6480

ctgaaatatg agttaagatg gagacagagt ttctcctaat aaccggagct gaattacctt     6540

tcactttcaa aaacatgacc ttccacaatc cttagaatct gccttttttt atattactga     6600

ggcctaaaag taaacattac tcattttatt ttgcccaaaa tgcactgatg taaagtagga     6660

aaaataaaaa cagagctcta aaatcccttt caagccaccc attgacccca ctcaccaact     6720

catagcaaag tcacttctgt taatccctta atctgatttt gtttggatat ttatcttgta     6780

cccgctgcta aacacactgc aggagggact ctgaaacctc aagctgtcta cttacatctt     6840

ttatctgtgt ctgtgtatca tgaaaatgtc tattcaaaat atcaaaacct ttcaaatatc     6900

acgcagctta tattcagttt acataaaggc cccaaatacc atgtcagatc tttttggtaa     6960

aagagttaat gaactatgag aattgggatt acatcatgta ttttgcctca tgtattttta     7020

tcacacttat aggccaagtg tgataaataa acttacagac actgaattaa tttcccctgc     7080

tactttgaaa ccagaaaata atgactggcc attcgttaca tctgtcttag ttgaaaagca     7140

tattttttat taaattaatt ctgattgtat ttgaaattat tattcaattc acttatggca     7200

gaggaatatc aatcctaatg acttctaaaa atgtaactaa ttgaatcatt atcttacatt     7260

tactgtttaa taagcatatt ttgaaaatgt atggctagag tgtcataata aaatggtata     7320

tctttcttta gtaattacat taaaattagt catgtttgat taattagttc                7370


<210>  164
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ile Thr Pro Thr Val Lys Met His Thr Met Ser Ser Ser His Leu 
1               5                   10                  15      


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
            20                  25                  30          


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
        35                  40                  45              


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
    50                  55                  60                  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
65                  70                  75                  80  


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
                85                  90                  95      


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
            100                 105                 110         


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
        115                 120                 125             


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
    130                 135         


<210>  165
<211>  7204
<212>  DNA
<213>  Homo sapiens

<400>  165
gcatacctgc ctgggtgtcc aaatgtaact agatgctttc acaaacccca cccacaaagc       60

agcacatgtt tttaagactt cagttttcta ttcacatcgg cctcataata cccaccctga      120

cctgctgtaa aagacctgga acaaacaaaa atgattacac ctacagtgaa gatgcacacc      180

atgtcctcct cgcatctctt ctacctggcg ctgtgcctgc tcaccttcac cagctctgcc      240

acggctggac cggagacgct ctgcggggct gagctggtgg atgctcttca gttcgtgtgt      300

ggagacaggg gcttttattt caacaagccc acagggtatg gctccagcag tcggagggcg      360

cctcagacag gcatcgtgga tgagtgctgc ttccggagct gtgatctaag gaggctggag      420

atgtattgcg cacccctcaa gcctgccaag tcagctcgct ctgtccgtgc ccagcgccac      480

accgacatgc ccaagaccca gaaggaagta catttgaaga acgcaagtag agggagtgca      540

ggaaacaaga actacaggat gtaggaagac cctcctgagg agtgaagagt gacatgccac      600

cgcaggatcc tttgctctgc acgagttacc tgttaaactt tggaacacct accaaaaaat      660

aagtttgata acatttaaaa gatgggcgtt tcccccaatg aaatacacaa gtaaacattc      720

caacattgtc tttaggagtg atttgcacct tgcaaaaatg gtcctggagt tggtagattg      780

ctgttgatct tttatcaata atgttctata gaaaagaaaa aaaaaatata tatatatata      840

tatcttagtc cctgcctctc aagagccaca aatgcatggg tgttgtatag atccagttgc      900

actaaattcc tctctgaatc ttggctgctg gagccattca ttcagcaacc ttgtctaagt      960

ggtttatgaa ttgtttcctt atttgcactt ctttctacac aactcgggct gtttgtttta     1020

cagtgtctga taatcttgtt agtctatacc caccacctcc cttcataacc tttatatttg     1080

ccgaatttgg cctcctcaaa agcagcagca agtcgtcaag aagcacacca attctaaccc     1140

acaagattcc atctgtggca tttgtaccaa atataagttg gatgcatttt attttagaca     1200

caaagcttta tttttccaca tcatgcttac aaaaaagaat aatgcaaata gttgcaactt     1260

tgaggccaat catttttagg catatgtttt aaacatagaa agtttcttca actcaaaaga     1320

gttccttcaa atgatgagtt aatgtgcaac ctaattagta actttcctct ttttattttt     1380

tccatataga gcactatgta aatttagcat atcaattata caggatatat caaacagtat     1440

gtaaaactct gttttttagt ataatggtgc tattttgtag tttgttatat gaaagagtct     1500

ggccaaaacg gtaatacgtg aaagcaaaac aataggggaa gcctggagcc aaagatgaca     1560

caaggggaag ggtactgaaa acaccatcca tttgggaaag aaggcaaagt ccccccagtt     1620

atgccttcca agaggaactt cagacacaaa agtccactga tgcaaattgg actggcgagt     1680

ccagagagga aactgtggaa tggaaaaagc agaaggctag gaattttagc agtcctggtt     1740

tctttttctc atggaagaaa tgaacatctg ccagctgtgt catggactca ccactgtgtg     1800

accttgggca agtcacttca cctctctgtg cctcagtttc ctcatctgca aaatgggggc     1860

aatatgtcat ctacctacct caaaggggtg gtataaggtt taaaaagata aagattcaga     1920

ttttttttac cctgggttgc tgtaagggtg caacatcagg gcgcttgagt tgctgagatg     1980

caaggaattc tataaataac ccattcatag catagctaga gattggtgaa ttgaatgctc     2040

ctgacatctc agttcttgtc agtgaagcta tccaaataac tggccaacta gttgttaaaa     2100

gctaacagct caatctctta aaacactttt caaaatatgt gggaagcatt tgattttcaa     2160

tttgattttg aattctgcat ttggttttat gaatacaaag ataagtgaaa agagagaaag     2220

gaaaagaaaa aggagaaaaa caaagagatt tctaccagtg aaaggggaat taattactct     2280

ttgttagcac tcactgactc ttctatgcag ttactacata tctagtaaaa cctcgtttaa     2340

tactataaat aatattctat tcattttgaa aaacacaatg attccttctt ttctaggcaa     2400

tataaggaaa gtgatccaaa atttgaaata ttaaaataat atctaataaa aagtcacaaa     2460

gttatcttct ttaacaaact ttactcttat tcttagctgt atatacattt ttttaaaagt     2520

ttgttaaaat atgcttgact agagtttcca gttgaaaggc aaaaacttcc atcacaacaa     2580

gaaatttccc atgcctgctc agaagggtag cccctagctc tctgtgaatg tgttttatcc     2640

attcaactga aaattggtat caagaaagtc cactggttag tgtactagtc catcatagcc     2700

tagaaaatga tccctatctg cagatcaaga ttttctcatt agaacaatga attatccagc     2760

attcagatct ttctagtcac cttagaactt tttggttaaa agtacccagg cttgattatt     2820

tcatgcaaat tctatatttt acattcttgg aaagtctata tgaaaaacaa aaataacatc     2880

ttcagttttt ctcccactgg gtcacctcaa ggatcagagg ccaggaaaaa aaaaaaaaag     2940

actccctgga tctctgaata tatgcaaaaa gaaggcccca tttagtggag ccagcaatcc     3000

tgttcagtca acaagtattt taactctcag tccaacatta tttgaattga gcacctcaag     3060

catgcttagc aatgttctaa tcactatgga cagatgtaaa agaaactata catcattttt     3120

gccctctgcc tgttttccag acatacaggt tctgtggaat aagatactgg actcctcttc     3180

ccaagatggc acttcttttt atttcttgtc cccagtgtgt accttttaaa attattccct     3240

ctcaacaaaa ctttataggc agtcttctgc agacttaacg tgttttctgt catagttaga     3300

tgtgataatt ctaagagtgt ctatgactta tttccttcac ttaattctat ccacagtcaa     3360

aaatccccca aggaggaaag ctgaaagatg cactgccata ttatctttct taactttttc     3420

caacacataa tcctctccaa ctggattata aataaattga aaataactca ttataccaat     3480

tcactatttt attttttaat gaattaaaac tagaaaacaa attgatgcaa accctggaag     3540

tcagttgatt actatatact acagcagaat gactcagatt tcatagaaag gagcaaccaa     3600

aatgtcacaa cccaaaactt tacaagcttt gcttcagaat tagattgctt tataattctt     3660

gaatgaggca atttcaagat atttgtaaaa gaacagtaaa cattggtaag aatgagcttt     3720

caactcatag gcttatttcc aatttaattg accatactgg atacttaggt caaatttctg     3780

ttctctcttc cccaaataat attaaagtat tatttgaact ttttaagatg aggcagttcc     3840

cctgaaaaag ttaatgcagc tctccatcag aatccactct tctagggata tgaaaatctc     3900

ttaacaccca ccctacatac acagacacac acacacacac acacacacac acacacacac     3960

acattcaccc taaggatcca atggaatact gaaaagaaat cacttccttg aaaattttat     4020

taaaaaacaa acaaacaaac aaaaagcctg tccacccttg agaatccttc ctctccttgg     4080

aacgtcaatg tttgtgtaga tgaaaccatc tcatgctctg tggctccagg gtttctgtta     4140

ctattttatg cacttgggag aaggcttaga ataaaagatg tagcacattt tgctttccca     4200

tttattgttt ggccagctat gccaatgtgg tgctattgtt tctttaagaa agtacttgac     4260

taaaaaaaaa agaaaaaaag aaaaaaaaga aagcatagac atattttttt aaagtataaa     4320

aacaacaatt ctatagatag atggcttaat aaaatagcat taggtctatc tagccaccac     4380

cacctttcaa ctttttatca ctcacaagta gtgtactgtt caccaaattg tgaatttggg     4440

ggtgcagggg caggagttgg aaatttttta aagttagaag gctccattgt tttgttggct     4500

ctcaaactta gcaaaattag caatatatta tccaatcttc tgaacttgat caagagcatg     4560

gagaataaac gcgggaaaaa agatcttata ggcaaataga agaatttaaa agataagtaa     4620

gttccttatt gatttttgtg cactctgctc taaaacagat attcagcaag tggagaaaat     4680

aagaacaaag agaaaaaata catagattta cctgcaaaaa atagcttctg ccaaatcccc     4740

cttgggtatt ctttggcatt tactggttta tagaagacat tctcccttca cccagacatc     4800

tcaaagagca gtagctctca tgaaaagcaa tcactgatct catttgggaa atgttggaaa     4860

gtatttcctt atgagatggg ggttatctac tgataaagaa agaatttatg agaaattgtt     4920

gaaagagatg gctaacaatc tgtgaagatt ttttgtttct tgtttttgtt tttttttttt     4980

ttttacttta tacagtcttt atgaatttct taatgttcaa aatgacttgg ttcttttctt     5040

ctttttttat atcagaatga ggaataataa gttaaaccca catagactct ttaaaactat     5100

aggctagata gaaatgtatg tttgacttgt tgaagctata atcagactat ttaaaatgtt     5160

ttgctatttt taatcttaaa agattgtgct aatttattag agcagaacct gtttggctct     5220

cctcagaaga aagaatcttt ccattcaaat cacatggctt tccaccaata ttttcaaaag     5280

ataaatctga tttatgcaat ggcatcattt attttaaaac agaagaattg tgaaagttta     5340

tgcccctccc ttgcaaagac cataaagtcc agatctggta ggggggcaac aacaaaagga     5400

aaatgttgtt gattcttggt tttggatttt gttttgtttt caatgctagt gtttaatcct     5460

gtagtacata tttgcttatt gctattttaa tattttataa gaccttcctg ttaggtatta     5520

gaaagtgata catagatatc ttttttgtgt aatttctatt taaaaaagag agaagactgt     5580

cagaagcttt aagtgcatat ggtacaggat aaagatatca atttaaataa ccaattccta     5640

tctggaacaa tgcttttgtt ttttaaagaa acctctcaca gataagacag aggcccaggg     5700

gatttttgaa gctgtcttta ttctgccccc atcccaaccc agcccttatt attttagtat     5760

ctgcctcaga attttataga gggctgacca agctgaaact ctagaattaa aggaacctca     5820

ctgaaaacat atatttcacg tgttccctct tttttttttt cctttttgtg agatggggtc     5880

tcgcactgtc ccccaggctg gagtgcagtg gcatgatctc ggctcactgc aacctccacc     5940

tcctgggttt aagcgattct cctgcctcag cctcctgagt agctgggatt acaggcaccc     6000

accactatgc ccggctaatt ttttggattt ttaatagaga cggggtttta ccatgttggc     6060

caggttggtc tcaaactcct gaccttgtga tttgcccgcc tcagcctccc aaattgctgg     6120

gattacaggc atgagccacc acaccctgcc catgtgttcc ctcttaatgt atgattacat     6180

ggatcttaaa catgatcctt ctctcctcat tcttcaacta tctttgatgg ggtctttcaa     6240

ggggaaaaaa atccaagctt ttttaaagta aaaaaaaaaa aagagaggac acaaaaccaa     6300

atgttactgc tcaactgaaa tatgagttaa gatggagaca gagtttctcc taataaccgg     6360

agctgaatta cctttcactt tcaaaaacat gaccttccac aatccttaga atctgccttt     6420

ttttatatta ctgaggccta aaagtaaaca ttactcattt tattttgccc aaaatgcact     6480

gatgtaaagt aggaaaaata aaaacagagc tctaaaatcc ctttcaagcc acccattgac     6540

cccactcacc aactcatagc aaagtcactt ctgttaatcc cttaatctga ttttgtttgg     6600

atatttatct tgtacccgct gctaaacaca ctgcaggagg gactctgaaa cctcaagctg     6660

tctacttaca tcttttatct gtgtctgtgt atcatgaaaa tgtctattca aaatatcaaa     6720

acctttcaaa tatcacgcag cttatattca gtttacataa aggccccaaa taccatgtca     6780

gatctttttg gtaaaagagt taatgaacta tgagaattgg gattacatca tgtattttgc     6840

ctcatgtatt tttatcacac ttataggcca agtgtgataa ataaacttac agacactgaa     6900

ttaatttccc ctgctacttt gaaaccagaa aataatgact ggccattcgt tacatctgtc     6960

ttagttgaaa agcatatttt ttattaaatt aattctgatt gtatttgaaa ttattattca     7020

attcacttat ggcagaggaa tatcaatcct aatgacttct aaaaatgtaa ctaattgaat     7080

cattatctta catttactgt ttaataagca tattttgaaa atgtatggct agagtgtcat     7140

aataaaatgg tatatctttc tttagtaatt acattaaaat tagtcatgtt tgattaatta     7200

gttc                                                                  7204


<210>  166
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 
145                 150                 155                 160 


Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 
                165                 170                 175     


Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys 
            180                 185                 190         


Lys Gly Lys 
        195 


<210>  167
<211>  949
<212>  DNA
<213>  Homo sapiens

<400>  167
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240

ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300

tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360

gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420

gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480

cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540

tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600

gacatgccca agacccagaa gtatcagccc ccatctacca acaagaacac gaagtctcag      660

agaaggaaag gttggccaaa gacacatcca ggaggggaac agaaggaggg gacagaagca      720

agtctgcaga tcagaggaaa gaagaaagag cagaggaggg agattggaag tagaaatgct      780

gaatgcagag gcaaaaaagg aaaatgaagg acaggaggat taaacagaca gaggcaagga      840

tgatgagaga ggagcagaca gcaagaatga aaagcagaaa atacaataga ggaaatgaag      900

aaaagtaggc ctgctggagc tagatgatga tgtgatggaa atagaagta                  949


<210>  168
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  169
<211>  5188
<212>  DNA
<213>  Homo sapiens

<400>  169
cgcctgtccc cctcccgagg cccgggctcg cgacggcaga gggctccgtc ggcccaaacc       60

gagctgggcg cccgcggtcc gggtgcagcc tccactccgc cccccagtca ccgcctcccc      120

cggcccctcg acgtggcgcc cttccctccg cttctctgtg ctccccgcgc ccctcttggc      180

gtctggcccc ggcccccgct ctttctcccg caaccttccc ttcgctccct cccgtccccc      240

ccagctccta gcctccgact ccctcccccc ctcacgcccg ccctctcgcc ttcgccgaac      300

caaagtggat taattacacg ctttctgttt ctctccgtgc tgttctctcc cgctgtgcgc      360

ctgcccgcct ctcgctgtcc tctctccccc tcgccctctc ttcggccccc ccctttcacg      420

ttcactctgt ctctcccact atctctgccc ccctctatcc ttgatacaac agctgacctc      480

atttcccgat accttttccc ccccgaaaag tacaacatct ggcccgcccc agcccgaaga      540

cagcccgtcc tccctggaca atcagacgaa ttctcccccc ccccccaaaa aaaagccatc      600

cccccgctct gccccgtcgc acattcggcc cccgcgactc ggccagagcg gcgctggcag      660

aggagtgtcc ggcaggaggg ccaacgcccg ctgttcggtt tgcgacacgc agcagggagg      720

tgggcggcag cgtcgccggc ttccagacac caatgggaat cccaatgggg aagtcgatgc      780

tggtgcttct caccttcttg gccttcgcct cgtgctgcat tgctgcttac cgccccagtg      840

agaccctgtg cggcggggag ctggtggaca ccctccagtt cgtctgtggg gaccgcggct      900

tctacttcag caggcccgca agccgtgtga gccgtcgcag ccgtggcatc gttgaggagt      960

gctgtttccg cagctgtgac ctggccctcc tggagacgta ctgtgctacc cccgccaagt     1020

ccgagaggga cgtgtcgacc cctccgaccg tgcttccgga caacttcccc agataccccg     1080

tgggcaagtt cttccaatat gacacctgga agcagtccac ccagcgcctg cgcaggggcc     1140

tgcctgccct cctgcgtgcc cgccggggtc acgtgctcgc caaggagctc gaggcgttca     1200

gggaggccaa acgtcaccgt cccctgattg ctctacccac ccaagacccc gcccacgggg     1260

gcgccccccc agagatggcc agcaatcgga agtgagcaaa actgccgcaa gtctgcagcc     1320

cggcgccacc atcctgcagc ctcctcctga ccacggacgt ttccatcagg ttccatcccg     1380

aaaatctctc ggttccacgt ccccctgggg cttctcctga cccagtcccc gtgccccgcc     1440

tccccgaaac aggctactct cctcggcccc ctccatcggg ctgaggaagc acagcagcat     1500

cttcaaacat gtacaaaatc gattggcttt aaacaccctt cacataccct ccccccaaat     1560

tatccccaat tatccccaca cataaaaaat caaaacatta aactaacccc cttccccccc     1620

ccccacaaca accctcttaa aactaattgg ctttttagaa acaccccaca aaagctcaga     1680

aattggcttt aaaaaaaaca accaccaaaa aaaatcaatt ggctaaaaaa aaaaagtatt     1740

aaaaacgaat tggctgagaa acaattggca aaataaagga atttggcact ccccaccccc     1800

ctctttctct tctcccttgg actttgagtc aaattggcct ggacttgagt ccctgaacca     1860

gcaaagagaa aagaaggacc ccagaaatca caggtgggca cgtcgctgct accgccatct     1920

cccttctcac gggaattttc agggtaaact ggccatccga aaatagcaac aacccagact     1980

ggctcctcac tcccttttcc atcactaaaa atcacagagc agtcagaggg acccagtaag     2040

accaaaggag gggaggacag agcatgaaaa ccaaaatcca tgcaaatgaa atgtaattgg     2100

cacgaccctc acccccaaat cttacatctc aattcccatc ctaaaaagca ctcatacttt     2160

atgcatcccc gcagctacac acacacaaca cacagcacac gcatgaacac agcacacaca     2220

cgagcacagc acacacacaa acgcacagca cacacagcac acagatgagc acacagcaca     2280

cacacaaacg cacagcacac acacgcacac acatgcacac acagcacaca aacgcacggc     2340

acacacacgc acacacatgc acacacagca cacacacaaa cgcacagcac acacaaacgc     2400

acagcacaca cgcacacaca gcacacacac gagcacacag cacacaaacg cacagcacac     2460

gcacacacat gcacacacag cacacacact agcacacagc acacacacaa agacacagca     2520

cacacatgca cacacagcac acacacgcga acacagcaca cacgaacaca gcacacacag     2580

cacacacaca aacacagcac acacatgcac acagcacacg cacacacagc acacacatga     2640

acacagcaca cagcacacac atgcacacac agcacacacg catgcacagc acacatgaac     2700

acagcacaca cacaaacaca cagcacacac atgcacacac agcacacaca ctcatgcgca     2760

gcacatacat gaacacagct cacagcacac aaacacgcag cacacacgtt gcacacgcaa     2820

gcacccacct gcacacacac atgcgcacac acacgcacac ccccacaaaa ttggatgaaa     2880

acaataagca tatctaagca actacgatat ctgtatggat caggccaaag tcccgctaag     2940

attctccaat gttttcatgg tctgagcccc gctcctgttc ccatctccac tgcccctcgg     3000

ccctgtctgt gccctgcctc tcagaggagg gggctcagat ggtgcggcct gagtgtgcgg     3060

ccggcggcat ttgggataca cccgtagggt gggcggggtg tgtcccaggc ctaattccat     3120

ctttccacca tgacagagat gcccttgtga ggctggcctc cttggcgcct gtccccacgg     3180

cccccgcagc gtgagccacg atgctcccca taccccaccc attcccgata caccttactt     3240

actgtgtgtt ggcccagcca gagtgaggaa ggagtttggc cacattggag atggcggtag     3300

ctgagcagac atgcccccac gagtagcctg actccctggt gtgctcctgg aaggaagatc     3360

ttggggaccc ccccaccgga gcacacctag ggatcatctt tgcccgtctc ctggggaccc     3420

cccaagaaat gtggagtcct cgggggccgt gcactgatgc ggggagtgtg ggaagtctgg     3480

cggttggagg ggtgggtggg gggcagtggg ggctgggcgg ggggagttct ggggtaggaa     3540

gtggtcccgg gagattttgg atggaaaagt caggaggatt gacagcagac ttgcagaatt     3600

acatagagaa attaggaacc cccaaatttc atgtcaattg atctattccc cctctttgtt     3660

tcttggggca tttttccttt tttttttttt tttgtttttt ttttacccct ccttagcttt     3720

atgcgctcag aaaccaaatt aaaccccccc cccatgtaac aggggggcag tgacaaaagc     3780

aagaacgcac gaagccagcc tggagaccac cacgtcctgc cccccgccat ttatcgccct     3840

gattggattt tgtttttcat ctgtccctgt tgcttgggtt gagttgaggg tggagcctcc     3900

tggggggcac tggccactga gcccccttgg agaagtcaga ggggagtgga gaaggccact     3960

gtccggcctg gcttctgggg acagtggctg gtccccagaa gtcctgaggg cggagggggg     4020

ggttgggcag ggtctcctca ggtgtcagga gggtgctcgg aggccacagg agggggctcc     4080

tggctggcct gaggctggcc ggaggggaag gggctagcag gtgtgtaaac agagggttcc     4140

atcaggctgg ggcagggtgg ccgccttccg cacacttgag gaaccctccc ctctccctcg     4200

gtgacatctt gcccgcccct cagcaccctg ccttgtctcc aggaggtccg aagctctgtg     4260

ggacctcttg ggggcaaggt ggggtgaggc cggggagtag ggaggtcagg cgggtctgag     4320

cccacagagc aggagagctg ccaggtctgc ccatcgacca ggttgcttgg gccccggagc     4380

ccacgggtct ggtgatgcca tagcagccac caccgcggcg cctagggctg cggcagggac     4440

tcggcctctg ggaggtttac ctcgccccca cttgtgcccc cagctcagcc cccctgcacg     4500

cagcccgact agcagtctag aggcctgagg cttctgggtc ctggtgacgg ggctggcatg     4560

accccggggg tcgtccatgc cagtccgcct cagtcgcaga gggtccctcg gcaagcgccc     4620

tgtgagtggg ccattcggaa cattggacag aagcccaaag agccaaattg tcacaattgt     4680

ggaacccaca ttggcctgag atccaaaacg cttcgaggca ccccaaatta cctgcccatt     4740

cgtcaggaca cccacccacc cagtgttata ttctgcctcg ccggagtggg tgttcccggg     4800

ggcacttgcc gaccagcccc ttgcgtcccc aggtttgcag ctctcccctg ggccactaac     4860

catcctggcc cgggctgcct gtctgacctc cgtgcctagt cgtggctctc catcttgtct     4920

cctccccgtg tccccaatgt cttcagtggg gggccccctc ttgggtcccc tcctctgcca     4980

tcacctgaag acccccacgc caaacactga atgtcacctg tgcctgccgc ctcggtccac     5040

cttgcggccc gtgtttgact caactcaact cctttaacgc taatatttcc ggcaaaatcc     5100

catgcttggg ttttgtcttt aaccttgtaa cgcttgcaat cccaataaag cattaaaagt     5160

catgatcttc aaaaaaaaaa aaaaaaaa                                        5188


<210>  170
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  171
<211>  5162
<212>  DNA
<213>  Homo sapiens

<400>  171
ccgctaatgt accatgccct ggtgctggaa agtgcctgag ccagctgccc cagcggcctc       60

agcactacca agttggcaca aagctcccca aattcggagg ggctcaggga aacgagtgga      120

ggggatgagg aggtgagggg taaacccatc atttcagttg gcatttgagc aggtgccatg      180

ctcagcggag atgaggctct cccatctgta ggggccgtat taacatgcac actctaaaag      240

tgcccttcgt ttctccagcc tcagctttgt ccctctcctc ctccacgtca acctggccag      300

agggtctgga cgccacagcc agggcacccc ctgctttggt ggtgactgct aatattggcc      360

aggccggcgg atcatcgtcc aggcagtttc ggcagagagc cttgggcacc agtgactccc      420

cggtcctctt tatccactgt ccaggagctg cggggactgc gcagggacta gagtacaggg      480

gccgaagagt caccaccgag cttgtgtggg aggaggtgga ttccagcccc cagccccagg      540

gctctgaatc gctgccagct cagccccctg cccagcctgc cccacagcct gagccccagc      600

aggccagaga gcccagtcct gaggtgagct gctgtggcct gtggcccagg cgaccccagc      660

gctcccagaa ctgaggctgg cagccagccc cagcctcagc cccaactgcg aggcagagag      720

acaccaatgg gaatcccaat ggggaagtcg atgctggtgc ttctcacctt cttggccttc      780

gcctcgtgct gcattgctgc ttaccgcccc agtgagaccc tgtgcggcgg ggagctggtg      840

gacaccctcc agttcgtctg tggggaccgc ggcttctact tcagcaggcc cgcaagccgt      900

gtgagccgtc gcagccgtgg catcgttgag gagtgctgtt tccgcagctg tgacctggcc      960

ctcctggaga cgtactgtgc tacccccgcc aagtccgaga gggacgtgtc gacccctccg     1020

accgtgcttc cggacaactt ccccagatac cccgtgggca agttcttcca atatgacacc     1080

tggaagcagt ccacccagcg cctgcgcagg ggcctgcctg ccctcctgcg tgcccgccgg     1140

ggtcacgtgc tcgccaagga gctcgaggcg ttcagggagg ccaaacgtca ccgtcccctg     1200

attgctctac ccacccaaga ccccgcccac gggggcgccc ccccagagat ggccagcaat     1260

cggaagtgag caaaactgcc gcaagtctgc agcccggcgc caccatcctg cagcctcctc     1320

ctgaccacgg acgtttccat caggttccat cccgaaaatc tctcggttcc acgtccccct     1380

ggggcttctc ctgacccagt ccccgtgccc cgcctccccg aaacaggcta ctctcctcgg     1440

ccccctccat cgggctgagg aagcacagca gcatcttcaa acatgtacaa aatcgattgg     1500

ctttaaacac ccttcacata ccctcccccc aaattatccc caattatccc cacacataaa     1560

aaatcaaaac attaaactaa cccccttccc ccccccccac aacaaccctc ttaaaactaa     1620

ttggcttttt agaaacaccc cacaaaagct cagaaattgg ctttaaaaaa aacaaccacc     1680

aaaaaaaatc aattggctaa aaaaaaaaag tattaaaaac gaattggctg agaaacaatt     1740

ggcaaaataa aggaatttgg cactccccac ccccctcttt ctcttctccc ttggactttg     1800

agtcaaattg gcctggactt gagtccctga accagcaaag agaaaagaag gaccccagaa     1860

atcacaggtg ggcacgtcgc tgctaccgcc atctcccttc tcacgggaat tttcagggta     1920

aactggccat ccgaaaatag caacaaccca gactggctcc tcactccctt ttccatcact     1980

aaaaatcaca gagcagtcag agggacccag taagaccaaa ggaggggagg acagagcatg     2040

aaaaccaaaa tccatgcaaa tgaaatgtaa ttggcacgac cctcaccccc aaatcttaca     2100

tctcaattcc catcctaaaa agcactcata ctttatgcat ccccgcagct acacacacac     2160

aacacacagc acacgcatga acacagcaca cacacgagca cagcacacac acaaacgcac     2220

agcacacaca gcacacagat gagcacacag cacacacaca aacgcacagc acacacacgc     2280

acacacatgc acacacagca cacaaacgca cggcacacac acgcacacac atgcacacac     2340

agcacacaca caaacgcaca gcacacacaa acgcacagca cacacgcaca cacagcacac     2400

acacgagcac acagcacaca aacgcacagc acacgcacac acatgcacac acagcacaca     2460

cactagcaca cagcacacac acaaagacac agcacacaca tgcacacaca gcacacacac     2520

gcgaacacag cacacacgaa cacagcacac acagcacaca cacaaacaca gcacacacat     2580

gcacacagca cacgcacaca cagcacacac atgaacacag cacacagcac acacatgcac     2640

acacagcaca cacgcatgca cagcacacat gaacacagca cacacacaaa cacacagcac     2700

acacatgcac acacagcaca cacactcatg cgcagcacat acatgaacac agctcacagc     2760

acacaaacac gcagcacaca cgttgcacac gcaagcaccc acctgcacac acacatgcgc     2820

acacacacgc acacccccac aaaattggat gaaaacaata agcatatcta agcaactacg     2880

atatctgtat ggatcaggcc aaagtcccgc taagattctc caatgttttc atggtctgag     2940

ccccgctcct gttcccatct ccactgcccc tcggccctgt ctgtgccctg cctctcagag     3000

gagggggctc agatggtgcg gcctgagtgt gcggccggcg gcatttggga tacacccgta     3060

gggtgggcgg ggtgtgtccc aggcctaatt ccatctttcc accatgacag agatgccctt     3120

gtgaggctgg cctccttggc gcctgtcccc acggcccccg cagcgtgagc cacgatgctc     3180

cccatacccc acccattccc gatacacctt acttactgtg tgttggccca gccagagtga     3240

ggaaggagtt tggccacatt ggagatggcg gtagctgagc agacatgccc ccacgagtag     3300

cctgactccc tggtgtgctc ctggaaggaa gatcttgggg acccccccac cggagcacac     3360

ctagggatca tctttgcccg tctcctgggg accccccaag aaatgtggag tcctcggggg     3420

ccgtgcactg atgcggggag tgtgggaagt ctggcggttg gaggggtggg tggggggcag     3480

tgggggctgg gcggggggag ttctggggta ggaagtggtc ccgggagatt ttggatggaa     3540

aagtcaggag gattgacagc agacttgcag aattacatag agaaattagg aacccccaaa     3600

tttcatgtca attgatctat tccccctctt tgtttcttgg ggcatttttc cttttttttt     3660

tttttttgtt ttttttttac ccctccttag ctttatgcgc tcagaaacca aattaaaccc     3720

cccccccatg taacaggggg gcagtgacaa aagcaagaac gcacgaagcc agcctggaga     3780

ccaccacgtc ctgccccccg ccatttatcg ccctgattgg attttgtttt tcatctgtcc     3840

ctgttgcttg ggttgagttg agggtggagc ctcctggggg gcactggcca ctgagccccc     3900

ttggagaagt cagaggggag tggagaaggc cactgtccgg cctggcttct ggggacagtg     3960

gctggtcccc agaagtcctg agggcggagg ggggggttgg gcagggtctc ctcaggtgtc     4020

aggagggtgc tcggaggcca caggaggggg ctcctggctg gcctgaggct ggccggaggg     4080

gaaggggcta gcaggtgtgt aaacagaggg ttccatcagg ctggggcagg gtggccgcct     4140

tccgcacact tgaggaaccc tcccctctcc ctcggtgaca tcttgcccgc ccctcagcac     4200

cctgccttgt ctccaggagg tccgaagctc tgtgggacct cttgggggca aggtggggtg     4260

aggccgggga gtagggaggt caggcgggtc tgagcccaca gagcaggaga gctgccaggt     4320

ctgcccatcg accaggttgc ttgggccccg gagcccacgg gtctggtgat gccatagcag     4380

ccaccaccgc ggcgcctagg gctgcggcag ggactcggcc tctgggaggt ttacctcgcc     4440

cccacttgtg cccccagctc agcccccctg cacgcagccc gactagcagt ctagaggcct     4500

gaggcttctg ggtcctggtg acggggctgg catgaccccg ggggtcgtcc atgccagtcc     4560

gcctcagtcg cagagggtcc ctcggcaagc gccctgtgag tgggccattc ggaacattgg     4620

acagaagccc aaagagccaa attgtcacaa ttgtggaacc cacattggcc tgagatccaa     4680

aacgcttcga ggcaccccaa attacctgcc cattcgtcag gacacccacc cacccagtgt     4740

tatattctgc ctcgccggag tgggtgttcc cgggggcact tgccgaccag ccccttgcgt     4800

ccccaggttt gcagctctcc cctgggccac taaccatcct ggcccgggct gcctgtctga     4860

cctccgtgcc tagtcgtggc tctccatctt gtctcctccc cgtgtcccca atgtcttcag     4920

tggggggccc cctcttgggt cccctcctct gccatcacct gaagaccccc acgccaaaca     4980

ctgaatgtca cctgtgcctg ccgcctcggt ccaccttgcg gcccgtgttt gactcaactc     5040

aactccttta acgctaatat ttccggcaaa atcccatgct tgggttttgt ctttaacctt     5100

gtaacgcttg caatcccaat aaagcattaa aagtcatgat cttcaaaaaa aaaaaaaaaa     5160

aa                                                                    5162


<210>  172
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Val Ser Pro Asp Pro Gln Ile Ile Val Val Ala Pro Glu Thr Glu 
1               5                   10                  15      


Leu Ala Ser Met Gln Val Gln Arg Thr Glu Asp Gly Val Thr Ile Ile 
            20                  25                  30          


Gln Ile Phe Trp Val Gly Arg Lys Gly Glu Leu Leu Arg Arg Thr Pro 
        35                  40                  45              


Val Ser Ser Ala Met Gln Thr Pro Met Gly Ile Pro Met Gly Lys Ser 
    50                  55                  60                  


Met Leu Val Leu Leu Thr Phe Leu Ala Phe Ala Ser Cys Cys Ile Ala 
65                  70                  75                  80  


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                85                  90                  95      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            100                 105                 110         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        115                 120                 125             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    130                 135                 140                 


Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 
145                 150                 155                 160 


Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 
                165                 170                 175     


Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 
            180                 185                 190         


Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 
        195                 200                 205             


Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 
    210                 215                 220                 


Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
225                 230                 235     


<210>  173
<211>  4875
<212>  DNA
<213>  Homo sapiens

<400>  173
acacacttgg gtcggccgcg cgccctcagg acgtggacag ggagggcttc cccgtgtcca       60

ggaaagcgac cgggcattgc ccccagtctc ccccaaattt gggcattgtc cccgggtctt      120

ccaacggact gggcgttgct cccggacact gaggactggc cccggggtct cgctcacctt      180

cagcagcgtc caccgcctgc cacagagcgt tcgatcgctc gctgcctgag ctcctggtgc      240

gcccgcggac gcagcctcca gcttcgcgga gatggtttcc ccagaccccc aaattatcgt      300

ggtggccccc gagaccgaac tcgcgtctat gcaagtccaa cgcactgagg acggggtaac      360

cattatccag atattttggg tgggccgcaa aggcgagcta cttagacgca ccccggtgag      420

ctcggccatg cagacaccaa tgggaatccc aatggggaag tcgatgctgg tgcttctcac      480

cttcttggcc ttcgcctcgt gctgcattgc tgcttaccgc cccagtgaga ccctgtgcgg      540

cggggagctg gtggacaccc tccagttcgt ctgtggggac cgcggcttct acttcagcag      600

gcccgcaagc cgtgtgagcc gtcgcagccg tggcatcgtt gaggagtgct gtttccgcag      660

ctgtgacctg gccctcctgg agacgtactg tgctaccccc gccaagtccg agagggacgt      720

gtcgacccct ccgaccgtgc ttccggacaa cttccccaga taccccgtgg gcaagttctt      780

ccaatatgac acctggaagc agtccaccca gcgcctgcgc aggggcctgc ctgccctcct      840

gcgtgcccgc cggggtcacg tgctcgccaa ggagctcgag gcgttcaggg aggccaaacg      900

tcaccgtccc ctgattgctc tacccaccca agaccccgcc cacgggggcg cccccccaga      960

gatggccagc aatcggaagt gagcaaaact gccgcaagtc tgcagcccgg cgccaccatc     1020

ctgcagcctc ctcctgacca cggacgtttc catcaggttc catcccgaaa atctctcggt     1080

tccacgtccc cctggggctt ctcctgaccc agtccccgtg ccccgcctcc ccgaaacagg     1140

ctactctcct cggccccctc catcgggctg aggaagcaca gcagcatctt caaacatgta     1200

caaaatcgat tggctttaaa cacccttcac ataccctccc cccaaattat ccccaattat     1260

ccccacacat aaaaaatcaa aacattaaac taaccccctt cccccccccc cacaacaacc     1320

ctcttaaaac taattggctt tttagaaaca ccccacaaaa gctcagaaat tggctttaaa     1380

aaaaacaacc accaaaaaaa atcaattggc taaaaaaaaa aagtattaaa aacgaattgg     1440

ctgagaaaca attggcaaaa taaaggaatt tggcactccc cacccccctc tttctcttct     1500

cccttggact ttgagtcaaa ttggcctgga cttgagtccc tgaaccagca aagagaaaag     1560

aaggacccca gaaatcacag gtgggcacgt cgctgctacc gccatctccc ttctcacggg     1620

aattttcagg gtaaactggc catccgaaaa tagcaacaac ccagactggc tcctcactcc     1680

cttttccatc actaaaaatc acagagcagt cagagggacc cagtaagacc aaaggagggg     1740

aggacagagc atgaaaacca aaatccatgc aaatgaaatg taattggcac gaccctcacc     1800

cccaaatctt acatctcaat tcccatccta aaaagcactc atactttatg catccccgca     1860

gctacacaca cacaacacac agcacacgca tgaacacagc acacacacga gcacagcaca     1920

cacacaaacg cacagcacac acagcacaca gatgagcaca cagcacacac acaaacgcac     1980

agcacacaca cgcacacaca tgcacacaca gcacacaaac gcacggcaca cacacgcaca     2040

cacatgcaca cacagcacac acacaaacgc acagcacaca caaacgcaca gcacacacgc     2100

acacacagca cacacacgag cacacagcac acaaacgcac agcacacgca cacacatgca     2160

cacacagcac acacactagc acacagcaca cacacaaaga cacagcacac acatgcacac     2220

acagcacaca cacgcgaaca cagcacacac gaacacagca cacacagcac acacacaaac     2280

acagcacaca catgcacaca gcacacgcac acacagcaca cacatgaaca cagcacacag     2340

cacacacatg cacacacagc acacacgcat gcacagcaca catgaacaca gcacacacac     2400

aaacacacag cacacacatg cacacacagc acacacactc atgcgcagca catacatgaa     2460

cacagctcac agcacacaaa cacgcagcac acacgttgca cacgcaagca cccacctgca     2520

cacacacatg cgcacacaca cgcacacccc cacaaaattg gatgaaaaca ataagcatat     2580

ctaagcaact acgatatctg tatggatcag gccaaagtcc cgctaagatt ctccaatgtt     2640

ttcatggtct gagccccgct cctgttccca tctccactgc ccctcggccc tgtctgtgcc     2700

ctgcctctca gaggaggggg ctcagatggt gcggcctgag tgtgcggccg gcggcatttg     2760

ggatacaccc gtagggtggg cggggtgtgt cccaggccta attccatctt tccaccatga     2820

cagagatgcc cttgtgaggc tggcctcctt ggcgcctgtc cccacggccc ccgcagcgtg     2880

agccacgatg ctccccatac cccacccatt cccgatacac cttacttact gtgtgttggc     2940

ccagccagag tgaggaagga gtttggccac attggagatg gcggtagctg agcagacatg     3000

cccccacgag tagcctgact ccctggtgtg ctcctggaag gaagatcttg gggacccccc     3060

caccggagca cacctaggga tcatctttgc ccgtctcctg gggacccccc aagaaatgtg     3120

gagtcctcgg gggccgtgca ctgatgcggg gagtgtggga agtctggcgg ttggaggggt     3180

gggtgggggg cagtgggggc tgggcggggg gagttctggg gtaggaagtg gtcccgggag     3240

attttggatg gaaaagtcag gaggattgac agcagacttg cagaattaca tagagaaatt     3300

aggaaccccc aaatttcatg tcaattgatc tattccccct ctttgtttct tggggcattt     3360

ttcctttttt tttttttttt gttttttttt tacccctcct tagctttatg cgctcagaaa     3420

ccaaattaaa cccccccccc atgtaacagg ggggcagtga caaaagcaag aacgcacgaa     3480

gccagcctgg agaccaccac gtcctgcccc ccgccattta tcgccctgat tggattttgt     3540

ttttcatctg tccctgttgc ttgggttgag ttgagggtgg agcctcctgg ggggcactgg     3600

ccactgagcc cccttggaga agtcagaggg gagtggagaa ggccactgtc cggcctggct     3660

tctggggaca gtggctggtc cccagaagtc ctgagggcgg aggggggggt tgggcagggt     3720

ctcctcaggt gtcaggaggg tgctcggagg ccacaggagg gggctcctgg ctggcctgag     3780

gctggccgga ggggaagggg ctagcaggtg tgtaaacaga gggttccatc aggctggggc     3840

agggtggccg ccttccgcac acttgaggaa ccctcccctc tccctcggtg acatcttgcc     3900

cgcccctcag caccctgcct tgtctccagg aggtccgaag ctctgtggga cctcttgggg     3960

gcaaggtggg gtgaggccgg ggagtaggga ggtcaggcgg gtctgagccc acagagcagg     4020

agagctgcca ggtctgccca tcgaccaggt tgcttgggcc ccggagccca cgggtctggt     4080

gatgccatag cagccaccac cgcggcgcct agggctgcgg cagggactcg gcctctggga     4140

ggtttacctc gcccccactt gtgcccccag ctcagccccc ctgcacgcag cccgactagc     4200

agtctagagg cctgaggctt ctgggtcctg gtgacggggc tggcatgacc ccgggggtcg     4260

tccatgccag tccgcctcag tcgcagaggg tccctcggca agcgccctgt gagtgggcca     4320

ttcggaacat tggacagaag cccaaagagc caaattgtca caattgtgga acccacattg     4380

gcctgagatc caaaacgctt cgaggcaccc caaattacct gcccattcgt caggacaccc     4440

acccacccag tgttatattc tgcctcgccg gagtgggtgt tcccgggggc acttgccgac     4500

cagccccttg cgtccccagg tttgcagctc tcccctgggc cactaaccat cctggcccgg     4560

gctgcctgtc tgacctccgt gcctagtcgt ggctctccat cttgtctcct ccccgtgtcc     4620

ccaatgtctt cagtgggggg ccccctcttg ggtcccctcc tctgccatca cctgaagacc     4680

cccacgccaa acactgaatg tcacctgtgc ctgccgcctc ggtccacctt gcggcccgtg     4740

tttgactcaa ctcaactcct ttaacgctaa tatttccggc aaaatcccat gcttgggttt     4800

tgtctttaac cttgtaacgc ttgcaatccc aataaagcat taaaagtcat gatcttcaaa     4860

aaaaaaaaaa aaaaa                                                      4875


<210>  174
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  175
<211>  4539
<212>  DNA
<213>  Homo sapiens

<400>  175
aaactggaca ttagcttctc ctgtgaaaga gacttccagc ttcctcctcc tcctcttcct       60

cctcctcctc ctgccccagc gagccttctg ctgagctaca ccaatgggaa tcccaatggg      120

gaagtcgatg ctggtgcttc tcaccttctt ggccttcgcc tcgtgctgca ttgctgctta      180

ccgccccagt gagaccctgt gcggcgggga gctggtggac accctccagt tcgtctgtgg      240

ggaccgcggc ttctacttca gcaggcccgc aagccgtgtg agccgtcgca gccgtggcat      300

cgttgaggag tgctgtttcc gcagctgtga cctggccctc ctggagacgt actgtgctac      360

ccccgccaag tccgagaggg acgtgtcgac ccctccgacc gtgcttccgg acaacttccc      420

cagatacccc gtgggcaagt tcttccaata tgacacctgg aagcagtcca cccagcgcct      480

gcgcaggggc ctgcctgccc tcctgcgtgc ccgccggggt cacgtgctcg ccaaggagct      540

cgaggcgttc agggaggcca aacgtcaccg tcccctgatt gctctaccca cccaagaccc      600

cgcccacggg ggcgcccccc cagagatggc cagcaatcgg aagtgagcaa aactgccgca      660

agtctgcagc ccggcgccac catcctgcag cctcctcctg accacggacg tttccatcag      720

gttccatccc gaaaatctct cggttccacg tccccctggg gcttctcctg acccagtccc      780

cgtgccccgc ctccccgaaa caggctactc tcctcggccc cctccatcgg gctgaggaag      840

cacagcagca tcttcaaaca tgtacaaaat cgattggctt taaacaccct tcacataccc      900

tccccccaaa ttatccccaa ttatccccac acataaaaaa tcaaaacatt aaactaaccc      960

ccttcccccc cccccacaac aaccctctta aaactaattg gctttttaga aacaccccac     1020

aaaagctcag aaattggctt taaaaaaaac aaccaccaaa aaaaatcaat tggctaaaaa     1080

aaaaaagtat taaaaacgaa ttggctgaga aacaattggc aaaataaagg aatttggcac     1140

tccccacccc cctctttctc ttctcccttg gactttgagt caaattggcc tggacttgag     1200

tccctgaacc agcaaagaga aaagaaggac cccagaaatc acaggtgggc acgtcgctgc     1260

taccgccatc tcccttctca cgggaatttt cagggtaaac tggccatccg aaaatagcaa     1320

caacccagac tggctcctca ctcccttttc catcactaaa aatcacagag cagtcagagg     1380

gacccagtaa gaccaaagga ggggaggaca gagcatgaaa accaaaatcc atgcaaatga     1440

aatgtaattg gcacgaccct cacccccaaa tcttacatct caattcccat cctaaaaagc     1500

actcatactt tatgcatccc cgcagctaca cacacacaac acacagcaca cgcatgaaca     1560

cagcacacac acgagcacag cacacacaca aacgcacagc acacacagca cacagatgag     1620

cacacagcac acacacaaac gcacagcaca cacacgcaca cacatgcaca cacagcacac     1680

aaacgcacgg cacacacacg cacacacatg cacacacagc acacacacaa acgcacagca     1740

cacacaaacg cacagcacac acgcacacac agcacacaca cgagcacaca gcacacaaac     1800

gcacagcaca cgcacacaca tgcacacaca gcacacacac tagcacacag cacacacaca     1860

aagacacagc acacacatgc acacacagca cacacacgcg aacacagcac acacgaacac     1920

agcacacaca gcacacacac aaacacagca cacacatgca cacagcacac gcacacacag     1980

cacacacatg aacacagcac acagcacaca catgcacaca cagcacacac gcatgcacag     2040

cacacatgaa cacagcacac acacaaacac acagcacaca catgcacaca cagcacacac     2100

actcatgcgc agcacataca tgaacacagc tcacagcaca caaacacgca gcacacacgt     2160

tgcacacgca agcacccacc tgcacacaca catgcgcaca cacacgcaca cccccacaaa     2220

attggatgaa aacaataagc atatctaagc aactacgata tctgtatgga tcaggccaaa     2280

gtcccgctaa gattctccaa tgttttcatg gtctgagccc cgctcctgtt cccatctcca     2340

ctgcccctcg gccctgtctg tgccctgcct ctcagaggag ggggctcaga tggtgcggcc     2400

tgagtgtgcg gccggcggca tttgggatac acccgtaggg tgggcggggt gtgtcccagg     2460

cctaattcca tctttccacc atgacagaga tgcccttgtg aggctggcct ccttggcgcc     2520

tgtccccacg gcccccgcag cgtgagccac gatgctcccc ataccccacc cattcccgat     2580

acaccttact tactgtgtgt tggcccagcc agagtgagga aggagtttgg ccacattgga     2640

gatggcggta gctgagcaga catgccccca cgagtagcct gactccctgg tgtgctcctg     2700

gaaggaagat cttggggacc cccccaccgg agcacaccta gggatcatct ttgcccgtct     2760

cctggggacc ccccaagaaa tgtggagtcc tcgggggccg tgcactgatg cggggagtgt     2820

gggaagtctg gcggttggag gggtgggtgg ggggcagtgg gggctgggcg gggggagttc     2880

tggggtagga agtggtcccg ggagattttg gatggaaaag tcaggaggat tgacagcaga     2940

cttgcagaat tacatagaga aattaggaac ccccaaattt catgtcaatt gatctattcc     3000

ccctctttgt ttcttggggc atttttcctt tttttttttt ttttgttttt tttttacccc     3060

tccttagctt tatgcgctca gaaaccaaat taaacccccc ccccatgtaa caggggggca     3120

gtgacaaaag caagaacgca cgaagccagc ctggagacca ccacgtcctg ccccccgcca     3180

tttatcgccc tgattggatt ttgtttttca tctgtccctg ttgcttgggt tgagttgagg     3240

gtggagcctc ctggggggca ctggccactg agcccccttg gagaagtcag aggggagtgg     3300

agaaggccac tgtccggcct ggcttctggg gacagtggct ggtccccaga agtcctgagg     3360

gcggaggggg gggttgggca gggtctcctc aggtgtcagg agggtgctcg gaggccacag     3420

gagggggctc ctggctggcc tgaggctggc cggaggggaa ggggctagca ggtgtgtaaa     3480

cagagggttc catcaggctg gggcagggtg gccgccttcc gcacacttga ggaaccctcc     3540

cctctccctc ggtgacatct tgcccgcccc tcagcaccct gccttgtctc caggaggtcc     3600

gaagctctgt gggacctctt gggggcaagg tggggtgagg ccggggagta gggaggtcag     3660

gcgggtctga gcccacagag caggagagct gccaggtctg cccatcgacc aggttgcttg     3720

ggccccggag cccacgggtc tggtgatgcc atagcagcca ccaccgcggc gcctagggct     3780

gcggcaggga ctcggcctct gggaggttta cctcgccccc acttgtgccc ccagctcagc     3840

ccccctgcac gcagcccgac tagcagtcta gaggcctgag gcttctgggt cctggtgacg     3900

gggctggcat gaccccgggg gtcgtccatg ccagtccgcc tcagtcgcag agggtccctc     3960

ggcaagcgcc ctgtgagtgg gccattcgga acattggaca gaagcccaaa gagccaaatt     4020

gtcacaattg tggaacccac attggcctga gatccaaaac gcttcgaggc accccaaatt     4080

acctgcccat tcgtcaggac acccacccac ccagtgttat attctgcctc gccggagtgg     4140

gtgttcccgg gggcacttgc cgaccagccc cttgcgtccc caggtttgca gctctcccct     4200

gggccactaa ccatcctggc ccgggctgcc tgtctgacct ccgtgcctag tcgtggctct     4260

ccatcttgtc tcctccccgt gtccccaatg tcttcagtgg ggggccccct cttgggtccc     4320

ctcctctgcc atcacctgaa gacccccacg ccaaacactg aatgtcacct gtgcctgccg     4380

cctcggtcca ccttgcggcc cgtgtttgac tcaactcaac tcctttaacg ctaatatttc     4440

cggcaaaatc ccatgcttgg gttttgtctt taaccttgta acgcttgcaa tcccaataaa     4500

gcattaaaag tcatgatctt caaaaaaaaa aaaaaaaaa                            4539


<210>  176
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  177
<211>  4710
<212>  DNA
<213>  Homo sapiens

<400>  177
acacacttgg gtcggccgcg cgccctcagg acgtggacag ggagggcttc cccgtgtcca       60

ggaaagcgac cgggcattgc ccccagtctc ccccaaattt gggcattgtc cccgggtctt      120

ccaacggact gggcgttgct cccggacact gaggactggc cccggggtct cgctcacctt      180

cagcagcgtc caccgcctgc cacagagcgt tcgatcgctc gctgcctgag ctcctggtgc      240

gcccgcggac gcagcctcca gcttcgcgac accaatggga atcccaatgg ggaagtcgat      300

gctggtgctt ctcaccttct tggccttcgc ctcgtgctgc attgctgctt accgccccag      360

tgagaccctg tgcggcgggg agctggtgga caccctccag ttcgtctgtg gggaccgcgg      420

cttctacttc agcaggcccg caagccgtgt gagccgtcgc agccgtggca tcgttgagga      480

gtgctgtttc cgcagctgtg acctggccct cctggagacg tactgtgcta cccccgccaa      540

gtccgagagg gacgtgtcga cccctccgac cgtgcttccg gacaacttcc ccagataccc      600

cgtgggcaag ttcttccaat atgacacctg gaagcagtcc acccagcgcc tgcgcagggg      660

cctgcctgcc ctcctgcgtg cccgccgggg tcacgtgctc gccaaggagc tcgaggcgtt      720

cagggaggcc aaacgtcacc gtcccctgat tgctctaccc acccaagacc ccgcccacgg      780

gggcgccccc ccagagatgg ccagcaatcg gaagtgagca aaactgccgc aagtctgcag      840

cccggcgcca ccatcctgca gcctcctcct gaccacggac gtttccatca ggttccatcc      900

cgaaaatctc tcggttccac gtccccctgg ggcttctcct gacccagtcc ccgtgccccg      960

cctccccgaa acaggctact ctcctcggcc ccctccatcg ggctgaggaa gcacagcagc     1020

atcttcaaac atgtacaaaa tcgattggct ttaaacaccc ttcacatacc ctccccccaa     1080

attatcccca attatcccca cacataaaaa atcaaaacat taaactaacc cccttccccc     1140

ccccccacaa caaccctctt aaaactaatt ggctttttag aaacacccca caaaagctca     1200

gaaattggct ttaaaaaaaa caaccaccaa aaaaaatcaa ttggctaaaa aaaaaaagta     1260

ttaaaaacga attggctgag aaacaattgg caaaataaag gaatttggca ctccccaccc     1320

ccctctttct cttctccctt ggactttgag tcaaattggc ctggacttga gtccctgaac     1380

cagcaaagag aaaagaagga ccccagaaat cacaggtggg cacgtcgctg ctaccgccat     1440

ctcccttctc acgggaattt tcagggtaaa ctggccatcc gaaaatagca acaacccaga     1500

ctggctcctc actccctttt ccatcactaa aaatcacaga gcagtcagag ggacccagta     1560

agaccaaagg aggggaggac agagcatgaa aaccaaaatc catgcaaatg aaatgtaatt     1620

ggcacgaccc tcacccccaa atcttacatc tcaattccca tcctaaaaag cactcatact     1680

ttatgcatcc ccgcagctac acacacacaa cacacagcac acgcatgaac acagcacaca     1740

cacgagcaca gcacacacac aaacgcacag cacacacagc acacagatga gcacacagca     1800

cacacacaaa cgcacagcac acacacgcac acacatgcac acacagcaca caaacgcacg     1860

gcacacacac gcacacacat gcacacacag cacacacaca aacgcacagc acacacaaac     1920

gcacagcaca cacgcacaca cagcacacac acgagcacac agcacacaaa cgcacagcac     1980

acgcacacac atgcacacac agcacacaca ctagcacaca gcacacacac aaagacacag     2040

cacacacatg cacacacagc acacacacgc gaacacagca cacacgaaca cagcacacac     2100

agcacacaca caaacacagc acacacatgc acacagcaca cgcacacaca gcacacacat     2160

gaacacagca cacagcacac acatgcacac acagcacaca cgcatgcaca gcacacatga     2220

acacagcaca cacacaaaca cacagcacac acatgcacac acagcacaca cactcatgcg     2280

cagcacatac atgaacacag ctcacagcac acaaacacgc agcacacacg ttgcacacgc     2340

aagcacccac ctgcacacac acatgcgcac acacacgcac acccccacaa aattggatga     2400

aaacaataag catatctaag caactacgat atctgtatgg atcaggccaa agtcccgcta     2460

agattctcca atgttttcat ggtctgagcc ccgctcctgt tcccatctcc actgcccctc     2520

ggccctgtct gtgccctgcc tctcagagga gggggctcag atggtgcggc ctgagtgtgc     2580

ggccggcggc atttgggata cacccgtagg gtgggcgggg tgtgtcccag gcctaattcc     2640

atctttccac catgacagag atgcccttgt gaggctggcc tccttggcgc ctgtccccac     2700

ggcccccgca gcgtgagcca cgatgctccc cataccccac ccattcccga tacaccttac     2760

ttactgtgtg ttggcccagc cagagtgagg aaggagtttg gccacattgg agatggcggt     2820

agctgagcag acatgccccc acgagtagcc tgactccctg gtgtgctcct ggaaggaaga     2880

tcttggggac ccccccaccg gagcacacct agggatcatc tttgcccgtc tcctggggac     2940

cccccaagaa atgtggagtc ctcgggggcc gtgcactgat gcggggagtg tgggaagtct     3000

ggcggttgga ggggtgggtg gggggcagtg ggggctgggc ggggggagtt ctggggtagg     3060

aagtggtccc gggagatttt ggatggaaaa gtcaggagga ttgacagcag acttgcagaa     3120

ttacatagag aaattaggaa cccccaaatt tcatgtcaat tgatctattc cccctctttg     3180

tttcttgggg catttttcct tttttttttt tttttgtttt ttttttaccc ctccttagct     3240

ttatgcgctc agaaaccaaa ttaaaccccc cccccatgta acaggggggc agtgacaaaa     3300

gcaagaacgc acgaagccag cctggagacc accacgtcct gccccccgcc atttatcgcc     3360

ctgattggat tttgtttttc atctgtccct gttgcttggg ttgagttgag ggtggagcct     3420

cctggggggc actggccact gagccccctt ggagaagtca gaggggagtg gagaaggcca     3480

ctgtccggcc tggcttctgg ggacagtggc tggtccccag aagtcctgag ggcggagggg     3540

ggggttgggc agggtctcct caggtgtcag gagggtgctc ggaggccaca ggagggggct     3600

cctggctggc ctgaggctgg ccggagggga aggggctagc aggtgtgtaa acagagggtt     3660

ccatcaggct ggggcagggt ggccgccttc cgcacacttg aggaaccctc ccctctccct     3720

cggtgacatc ttgcccgccc ctcagcaccc tgccttgtct ccaggaggtc cgaagctctg     3780

tgggacctct tgggggcaag gtggggtgag gccggggagt agggaggtca ggcgggtctg     3840

agcccacaga gcaggagagc tgccaggtct gcccatcgac caggttgctt gggccccgga     3900

gcccacgggt ctggtgatgc catagcagcc accaccgcgg cgcctagggc tgcggcaggg     3960

actcggcctc tgggaggttt acctcgcccc cacttgtgcc cccagctcag cccccctgca     4020

cgcagcccga ctagcagtct agaggcctga ggcttctggg tcctggtgac ggggctggca     4080

tgaccccggg ggtcgtccat gccagtccgc ctcagtcgca gagggtccct cggcaagcgc     4140

cctgtgagtg ggccattcgg aacattggac agaagcccaa agagccaaat tgtcacaatt     4200

gtggaaccca cattggcctg agatccaaaa cgcttcgagg caccccaaat tacctgccca     4260

ttcgtcagga cacccaccca cccagtgtta tattctgcct cgccggagtg ggtgttcccg     4320

ggggcacttg ccgaccagcc ccttgcgtcc ccaggtttgc agctctcccc tgggccacta     4380

accatcctgg cccgggctgc ctgtctgacc tccgtgccta gtcgtggctc tccatcttgt     4440

ctcctccccg tgtccccaat gtcttcagtg gggggccccc tcttgggtcc cctcctctgc     4500

catcacctga agacccccac gccaaacact gaatgtcacc tgtgcctgcc gcctcggtcc     4560

accttgcggc ccgtgtttga ctcaactcaa ctcctttaac gctaatattt ccggcaaaat     4620

cccatgcttg ggttttgtct ttaaccttgt aacgcttgca atcccaataa agcattaaaa     4680

gtcatgatct tcaaaaaaaa aaaaaaaaaa                                      4710


<210>  178
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  179
<211>  5600
<212>  DNA
<213>  Homo sapiens

<400>  179
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt     1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag     1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg     1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc     1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc     1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg     1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc     1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac     1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt     1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc     1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc     2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta     2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct     2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca     2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca     2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag     2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg     2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca     2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg     2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag     2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat     2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg     2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag     2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg     2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta     2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt     2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg     3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg     3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca     3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact     3180

gtcttgatat tgatgagtgc caactggggg agcacagctg tggagagaat gccagctgca     3240

caaatacaga gggaggctat acctgcatgt gtgctggacg cctgtctgaa ccaggactga     3300

tttgccctga ctctactcca ccccctcacc tcagggaaga tgaccaccac tattccgtaa     3360

gaaatagtga ctctgaatgt cccctgtccc acgatgggta ctgcctccat gatggtgtgt     3420

gcatgtatat tgaagcattg gacaagtatg catgcaactg tgttgttggc tacatcgggg     3480

agcgatgtca gtaccgagac ctgaagtggt gggaactgcg ccacgctggc cacgggcagc     3540

agcagaaggt catcgtggtg gctgtctgcg tggtggtgct tgtcatgctg ctcctcctga     3600

gcctgtgggg ggcccactac tacaggactc agaagctgct atcgaaaaac ccaaagaatc     3660

cttatgagga gtcgagcaga gatgtgagga gtcgcaggcc tgctgacact gaggatggga     3720

tgtcctcttg ccctcaacct tggtttgtgg ttataaaaga acaccaagac ctcaagaatg     3780

ggggtcaacc agtggctggt gaggatggcc aggcagcaga tgggtcaatg caaccaactt     3840

catggaggca ggagccccag ttatgtggaa tgggcacaga gcaaggctgc tggattccag     3900

tatccagtga taagggctcc tgtccccagg taatggagcg aagctttcat atgccctcct     3960

atgggacaca gacccttgaa gggggtgtcg agaagcccca ttctctccta tcagctaacc     4020

cattatggca acaaagggcc ctggacccac cacaccaaat ggagctgact cagtgaaaac     4080

tggaattaaa aggaaagtca agaagaatga actatgtcga tgcacagtat cttttctttc     4140

aaaagtagag caaaactata ggttttggtt ccacaatctc tacgactaat cacctactca     4200

atgcctggag acagatacgt agttgtgctt ttgtttgctc ttttaagcag tctcactgca     4260

gtcttatttc caagtaagag tactgggaga atcactaggt aacttattag aaacccaaat     4320

tgggacaaca gtgctttgta aattgtgttg tcttcagcag tcaatacaaa tagatttttg     4380

tttttgttgt tcctgcagcc ccagaagaaa ttaggggtta aagcagacag tcacactggt     4440

ttggtcagtt acaaagtaat ttctttgatc tggacagaac atttatatca gtttcatgaa     4500

atgattggaa tattacaata ccgttaagat acagtgtagg catttaactc ctcattggcg     4560

tggtccatgc tgatgatttt gcaaaatgag ttgtgatgaa tcaatgaaaa atgtaattta     4620

gaaactgatt tcttcagaat tagatggctt attttttaaa atatttgaat gaaaacattt     4680

tatttttaaa atattacaca ggaggcttcg gagtttctta gtcattactg tccttttccc     4740

ctacagaatt ttccctcttg gtgtgattgc acagaatttg tatgtatttt cagttacaag     4800

attgtaagta aattgcctga tttgttttca ttatagacaa cgatgaattt cttctaatta     4860

tttaaataaa atcaccaaaa acataaacat tttattgtat gcctgattaa gtagttaatt     4920

atagtctaag gcagtactag agttgaacca aaatgatttg tcaagcttgc tgatgtttct     4980

gtttttcgtt tttttttttt ttccggagag aggataggat ctcactctgt tatccaggct     5040

ggagtgtgca atggcacaat catagctcag tgcagcctca aactcctggg ctcaagcaat     5100

cctcctgcct cagcctcccg agtaactagg accacaggca caggccacca tgcctggcta     5160

aggtttttat ttttattttt tgtagacatg gggatcacac aatgttgccc aggctggtct     5220

tgaactcctg gcctcaagca aggtcgtgct ggtaattttg caaaatgaat tgtgattgac     5280

tttcagcctc ccaacgtatt agattatagg cattagccat ggtgcccagc cttgtaactt     5340

ttaaaaaaat tttttaatct acaactctgt agattaaaat ttcacatggt gttctaatta     5400

aatatttttc ttgcagccaa gatattgtta ctacagataa cacaacctga tatggtaact     5460

ttaaattttg ggggctttga atcattcagt ttatgcatta actagtccct ttgtttatct     5520

ttcatttctc aaccccttgt actttggtga taccagacat cagaataaaa agaaattgaa     5580

gtaaaaaaaa aaaaaaaaaa                                                 5600


<210>  180
<211>  1166
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ser Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val 
        915                 920                 925             


Arg Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
    930                 935                 940                 


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
945                 950                 955                 960 


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
                965                 970                 975     


Lys Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val 
            980                 985                 990         


Ile Val Val Ala Val Cys Val Val  Val Leu Val Met Leu  Leu Leu Leu 
        995                 1000                 1005             


Ser Leu  Trp Gly Ala His Tyr  Tyr Arg Thr Gln Lys  Leu Leu Ser 
    1010                 1015                 1020             


Lys Asn  Pro Lys Asn Pro Tyr  Glu Glu Ser Ser Arg  Asp Val Arg 
    1025                 1030                 1035             


Ser Arg  Arg Pro Ala Asp Thr  Glu Asp Gly Met Ser  Ser Cys Pro 
    1040                 1045                 1050             


Gln Pro  Trp Phe Val Val Ile  Lys Glu His Gln Asp  Leu Lys Asn 
    1055                 1060                 1065             


Gly Gly  Gln Pro Val Ala Gly  Glu Asp Gly Gln Ala  Ala Asp Gly 
    1070                 1075                 1080             


Ser Met  Gln Pro Thr Ser Trp  Arg Gln Glu Pro Gln  Leu Cys Gly 
    1085                 1090                 1095             


Met Gly  Thr Glu Gln Gly Cys  Trp Ile Pro Val Ser  Ser Asp Lys 
    1100                 1105                 1110             


Gly Ser  Cys Pro Gln Val Met  Glu Arg Ser Phe His  Met Pro Ser 
    1115                 1120                 1125             


Tyr Gly  Thr Gln Thr Leu Glu  Gly Gly Val Glu Lys  Pro His Ser 
    1130                 1135                 1140             


Leu Leu  Ser Ala Asn Pro Leu  Trp Gln Gln Arg Ala  Leu Asp Pro 
    1145                 1150                 1155             


Pro His  Gln Met Glu Leu Thr  Gln 
    1160                 1165     


<210>  181
<211>  5477
<212>  DNA
<213>  Homo sapiens

<400>  181
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt     1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag     1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg     1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc     1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc     1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg     1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc     1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac     1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt     1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc     1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc     2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta     2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct     2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca     2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca     2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag     2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg     2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca     2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg     2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag     2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat     2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg     2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag     2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg     2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta     2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt     2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg     3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg     3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca     3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact     3180

gtcttgactc tactccaccc cctcacctca gggaagatga ccaccactat tccgtaagaa     3240

atagtgactc tgaatgtccc ctgtcccacg atgggtactg cctccatgat ggtgtgtgca     3300

tgtatattga agcattggac aagtatgcat gcaactgtgt tgttggctac atcggggagc     3360

gatgtcagta ccgagacctg aagtggtggg aactgcgcca cgctggccac gggcagcagc     3420

agaaggtcat cgtggtggct gtctgcgtgg tggtgcttgt catgctgctc ctcctgagcc     3480

tgtggggggc ccactactac aggactcaga agctgctatc gaaaaaccca aagaatcctt     3540

atgaggagtc gagcagagat gtgaggagtc gcaggcctgc tgacactgag gatgggatgt     3600

cctcttgccc tcaaccttgg tttgtggtta taaaagaaca ccaagacctc aagaatgggg     3660

gtcaaccagt ggctggtgag gatggccagg cagcagatgg gtcaatgcaa ccaacttcat     3720

ggaggcagga gccccagtta tgtggaatgg gcacagagca aggctgctgg attccagtat     3780

ccagtgataa gggctcctgt ccccaggtaa tggagcgaag ctttcatatg ccctcctatg     3840

ggacacagac ccttgaaggg ggtgtcgaga agccccattc tctcctatca gctaacccat     3900

tatggcaaca aagggccctg gacccaccac accaaatgga gctgactcag tgaaaactgg     3960

aattaaaagg aaagtcaaga agaatgaact atgtcgatgc acagtatctt ttctttcaaa     4020

agtagagcaa aactataggt tttggttcca caatctctac gactaatcac ctactcaatg     4080

cctggagaca gatacgtagt tgtgcttttg tttgctcttt taagcagtct cactgcagtc     4140

ttatttccaa gtaagagtac tgggagaatc actaggtaac ttattagaaa cccaaattgg     4200

gacaacagtg ctttgtaaat tgtgttgtct tcagcagtca atacaaatag atttttgttt     4260

ttgttgttcc tgcagcccca gaagaaatta ggggttaaag cagacagtca cactggtttg     4320

gtcagttaca aagtaatttc tttgatctgg acagaacatt tatatcagtt tcatgaaatg     4380

attggaatat tacaataccg ttaagataca gtgtaggcat ttaactcctc attggcgtgg     4440

tccatgctga tgattttgca aaatgagttg tgatgaatca atgaaaaatg taatttagaa     4500

actgatttct tcagaattag atggcttatt ttttaaaata tttgaatgaa aacattttat     4560

ttttaaaata ttacacagga ggcttcggag tttcttagtc attactgtcc ttttccccta     4620

cagaattttc cctcttggtg tgattgcaca gaatttgtat gtattttcag ttacaagatt     4680

gtaagtaaat tgcctgattt gttttcatta tagacaacga tgaatttctt ctaattattt     4740

aaataaaatc accaaaaaca taaacatttt attgtatgcc tgattaagta gttaattata     4800

gtctaaggca gtactagagt tgaaccaaaa tgatttgtca agcttgctga tgtttctgtt     4860

tttcgttttt tttttttttc cggagagagg ataggatctc actctgttat ccaggctgga     4920

gtgtgcaatg gcacaatcat agctcagtgc agcctcaaac tcctgggctc aagcaatcct     4980

cctgcctcag cctcccgagt aactaggacc acaggcacag gccaccatgc ctggctaagg     5040

tttttatttt tattttttgt agacatgggg atcacacaat gttgcccagg ctggtcttga     5100

actcctggcc tcaagcaagg tcgtgctggt aattttgcaa aatgaattgt gattgacttt     5160

cagcctccca acgtattaga ttataggcat tagccatggt gcccagcctt gtaactttta     5220

aaaaaatttt ttaatctaca actctgtaga ttaaaatttc acatggtgtt ctaattaaat     5280

atttttcttg cagccaagat attgttacta cagataacac aacctgatat ggtaacttta     5340

aattttgggg gctttgaatc attcagttta tgcattaact agtccctttg tttatctttc     5400

atttctcaac cccttgtact ttggtgatac cagacatcag aataaaaaga aattgaagta     5460

aaaaaaaaaa aaaaaaa                                                    5477


<210>  182
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Asp Val Asn Glu Cys Ala Phe 
305                 310                 315                 320 


Trp Asn His Gly Cys Thr Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr 
                325                 330                 335     


Tyr Cys Thr Cys Pro Val Gly Phe Val Leu Leu Pro Asp Gly Lys Arg 
            340                 345                 350         


Cys His Gln Leu Val Ser Cys Pro Arg Asn Val Ser Glu Cys Ser His 
        355                 360                 365             


Asp Cys Val Leu Thr Ser Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly 
    370                 375                 380                 


Ser Val Leu Glu Arg Asp Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro 
385                 390                 395                 400 


Asp Asn Gly Gly Cys Ser Gln Leu Cys Val Pro Leu Ser Pro Val Ser 
                405                 410                 415     


Trp Glu Cys Asp Cys Phe Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys 
            420                 425                 430         


Ser Cys Ala Ala Ser Gly Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser 
        435                 440                 445             


Gln Asp Ile Arg His Met His Phe Asp Gly Thr Asp Tyr Gly Thr Leu 
    450                 455                 460                 


Leu Ser Gln Gln Met Gly Met Val Tyr Ala Leu Asp His Asp Pro Val 
465                 470                 475                 480 


Glu Asn Lys Ile Tyr Phe Ala His Thr Ala Leu Lys Trp Ile Glu Arg 
                485                 490                 495     


Ala Asn Met Asp Gly Ser Gln Arg Glu Arg Leu Ile Glu Glu Gly Val 
            500                 505                 510         


Asp Val Pro Glu Gly Leu Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr 
        515                 520                 525             


Trp Thr Asp Arg Gly Lys Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly 
    530                 535                 540                 


Lys Arg Ser Lys Ile Ile Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly 
545                 550                 555                 560 


Ile Ala Val His Pro Met Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly 
                565                 570                 575     


Ile Asn Pro Arg Ile Glu Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu 
            580                 585                 590         


Val Ile Ala Ser Ser Asp Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp 
        595                 600                 605             


Phe Leu Thr Asp Lys Leu Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile 
    610                 615                 620                 


Glu Met Ala Asn Leu Asp Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn 
625                 630                 635                 640 


Asp Val Gly His Pro Phe Ala Val Ala Val Phe Glu Asp Tyr Val Trp 
                645                 650                 655     


Phe Ser Asp Trp Ala Met Pro Ser Val Met Arg Val Asn Lys Arg Thr 
            660                 665                 670         


Gly Lys Asp Arg Val Arg Leu Gln Gly Ser Met Leu Lys Pro Ser Ser 
        675                 680                 685             


Leu Val Val Val His Pro Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu 
    690                 695                 700                 


Tyr Gln Asn Gly Gly Cys Glu His Ile Cys Lys Lys Arg Leu Gly Thr 
705                 710                 715                 720 


Ala Trp Cys Ser Cys Arg Glu Gly Phe Met Lys Ala Ser Asp Gly Lys 
                725                 730                 735     


Thr Cys Leu Ala Leu Asp Gly His Gln Leu Leu Ala Gly Gly Glu Val 
            740                 745                 750         


Asp Leu Lys Asn Gln Val Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg 
        755                 760                 765             


Val Ser Glu Asp Asn Ile Thr Glu Ser Gln His Met Leu Val Ala Glu 
    770                 775                 780                 


Ile Met Val Ser Asp Gln Asp Asp Cys Ala Pro Val Gly Cys Ser Met 
785                 790                 795                 800 


Tyr Ala Arg Cys Ile Ser Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu 
                805                 810                 815     


Lys Gly Phe Ala Gly Asp Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys 
            820                 825                 830         


Glu Met Gly Val Pro Val Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn 
        835                 840                 845             


Thr Glu Gly Gly Tyr Val Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp 
    850                 855                 860                 


Gly Ile His Cys Leu Asp Ile Asp Glu Cys Gln Leu Gly Glu His Ser 
865                 870                 875                 880 


Cys Gly Glu Asn Ala Ser Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys 
                885                 890                 895     


Met Cys Ala Gly Arg Leu Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser 
            900                 905                 910         


Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val Arg 
        915                 920                 925             


Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
    930                 935                 940                 


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
945                 950                 955                 960 


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
                965                 970                 975     


Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val Ile 
            980                 985                 990         


Val Val Ala Val Cys Val Val Val  Leu Val Met Leu Leu  Leu Leu Ser 
        995                 1000                 1005             


Leu Trp  Gly Ala His Tyr Tyr  Arg Thr Gln Lys Leu  Leu Ser Lys 
    1010                 1015                 1020             


Asn Pro  Lys Asn Pro Tyr Glu  Glu Ser Ser Arg Asp  Val Arg Ser 
    1025                 1030                 1035             


Arg Arg  Pro Ala Asp Thr Glu  Asp Gly Met Ser Ser  Cys Pro Gln 
    1040                 1045                 1050             


Pro Trp  Phe Val Val Ile Lys  Glu His Gln Asp Leu  Lys Asn Gly 
    1055                 1060                 1065             


Gly Gln  Pro Val Ala Gly Glu  Asp Gly Gln Ala Ala  Asp Gly Ser 
    1070                 1075                 1080             


Met Gln  Pro Thr Ser Trp Arg  Gln Glu Pro Gln Leu  Cys Gly Met 
    1085                 1090                 1095             


Gly Thr  Glu Gln Gly Cys Trp  Ile Pro Val Ser Ser  Asp Lys Gly 
    1100                 1105                 1110             


Ser Cys  Pro Gln Val Met Glu  Arg Ser Phe His Met  Pro Ser Tyr 
    1115                 1120                 1125             


Gly Thr  Gln Thr Leu Glu Gly  Gly Val Glu Lys Pro  His Ser Leu 
    1130                 1135                 1140             


Leu Ser  Ala Asn Pro Leu Trp  Gln Gln Arg Ala Leu  Asp Pro Pro 
    1145                 1150                 1155             


His Gln  Met Glu Leu Thr Gln  
    1160                 1165 


<210>  183
<211>  5474
<212>  DNA
<213>  Homo sapiens

<400>  183
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgatgttaat gaatgtgctt tttggaatca tggctgtact cttgggtgta     1440

aaaacacccc tggatcctat tactgcacgt gccctgtagg atttgttctg cttcctgatg     1500

ggaaacgatg tcatcaactt gtttcctgtc cacgcaatgt gtctgaatgc agccatgact     1560

gtgttctgac atcagaaggt cccttatgtt tctgtcctga aggctcagtg cttgagagag     1620

atgggaaaac atgtagcggt tgttcctcac ccgataatgg tggatgtagc cagctctgcg     1680

ttcctcttag cccagtatcc tgggaatgtg attgctttcc tgggtatgac ctacaactgg     1740

atgaaaaaag ctgtgcagct tcaggaccac aaccattttt gctgtttgcc aattctcaag     1800

atattcgaca catgcatttt gatggaacag actatggaac tctgctcagc cagcagatgg     1860

gaatggttta tgccctagat catgaccctg tggaaaataa gatatacttt gcccatacag     1920

ccctgaagtg gatagagaga gctaatatgg atggttccca gcgagaaagg cttattgagg     1980

aaggagtaga tgtgccagaa ggtcttgctg tggactggat tggccgtaga ttctattgga     2040

cagacagagg gaaatctctg attggaagga gtgatttaaa tgggaaacgt tccaaaataa     2100

tcactaagga gaacatctct caaccacgag gaattgctgt tcatccaatg gccaagagat     2160

tattctggac tgatacaggg attaatccac gaattgaaag ttcttccctc caaggccttg     2220

gccgtctggt tatagccagc tctgatctaa tctggcccag tggaataacg attgacttct     2280

taactgacaa gttgtactgg tgcgatgcca agcagtctgt gattgaaatg gccaatctgg     2340

atggttcaaa acgccgaaga cttacccaga atgatgtagg tcacccattt gctgtagcag     2400

tgtttgagga ttatgtgtgg ttctcagatt gggctatgcc atcagtaatg agagtaaaca     2460

agaggactgg caaagataga gtacgtctcc aaggcagcat gctgaagccc tcatcactgg     2520

ttgtggttca tccattggca aaaccaggag cagatccctg cttatatcaa aacggaggct     2580

gtgaacatat ttgcaaaaag aggcttggaa ctgcttggtg ttcgtgtcgt gaaggtttta     2640

tgaaagcctc agatgggaaa acgtgtctgg ctctggatgg tcatcagctg ttggcaggtg     2700

gtgaagttga tctaaagaac caagtaacac cattggacat cttgtccaag actagagtgt     2760

cagaagataa cattacagaa tctcaacaca tgctagtggc tgaaatcatg gtgtcagatc     2820

aagatgactg tgctcctgtg ggatgcagca tgtatgctcg gtgtatttca gagggagagg     2880

atgccacatg tcagtgtttg aaaggatttg ctggggatgg aaaactatgt tctgatatag     2940

atgaatgtga gatgggtgtc ccagtgtgcc cccctgcctc ctccaagtgc atcaacaccg     3000

aaggtggtta tgtctgccgg tgctcagaag gctaccaagg agatgggatt cactgtcttg     3060

atattgatga gtgccaactg ggggagcaca gctgtggaga gaatgccagc tgcacaaata     3120

cagagggagg ctatacctgc atgtgtgctg gacgcctgtc tgaaccagga ctgatttgcc     3180

ctgactctac tccaccccct cacctcaggg aagatgacca ccactattcc gtaagaaata     3240

gtgactctga atgtcccctg tcccacgatg ggtactgcct ccatgatggt gtgtgcatgt     3300

atattgaagc attggacaag tatgcatgca actgtgttgt tggctacatc ggggagcgat     3360

gtcagtaccg agacctgaag tggtgggaac tgcgccacgc tggccacggg cagcagcaga     3420

aggtcatcgt ggtggctgtc tgcgtggtgg tgcttgtcat gctgctcctc ctgagcctgt     3480

ggggggccca ctactacagg actcagaagc tgctatcgaa aaacccaaag aatccttatg     3540

aggagtcgag cagagatgtg aggagtcgca ggcctgctga cactgaggat gggatgtcct     3600

cttgccctca accttggttt gtggttataa aagaacacca agacctcaag aatgggggtc     3660

aaccagtggc tggtgaggat ggccaggcag cagatgggtc aatgcaacca acttcatgga     3720

ggcaggagcc ccagttatgt ggaatgggca cagagcaagg ctgctggatt ccagtatcca     3780

gtgataaggg ctcctgtccc caggtaatgg agcgaagctt tcatatgccc tcctatggga     3840

cacagaccct tgaagggggt gtcgagaagc cccattctct cctatcagct aacccattat     3900

ggcaacaaag ggccctggac ccaccacacc aaatggagct gactcagtga aaactggaat     3960

taaaaggaaa gtcaagaaga atgaactatg tcgatgcaca gtatcttttc tttcaaaagt     4020

agagcaaaac tataggtttt ggttccacaa tctctacgac taatcaccta ctcaatgcct     4080

ggagacagat acgtagttgt gcttttgttt gctcttttaa gcagtctcac tgcagtctta     4140

tttccaagta agagtactgg gagaatcact aggtaactta ttagaaaccc aaattgggac     4200

aacagtgctt tgtaaattgt gttgtcttca gcagtcaata caaatagatt tttgtttttg     4260

ttgttcctgc agccccagaa gaaattaggg gttaaagcag acagtcacac tggtttggtc     4320

agttacaaag taatttcttt gatctggaca gaacatttat atcagtttca tgaaatgatt     4380

ggaatattac aataccgtta agatacagtg taggcattta actcctcatt ggcgtggtcc     4440

atgctgatga ttttgcaaaa tgagttgtga tgaatcaatg aaaaatgtaa tttagaaact     4500

gatttcttca gaattagatg gcttattttt taaaatattt gaatgaaaac attttatttt     4560

taaaatatta cacaggaggc ttcggagttt cttagtcatt actgtccttt tcccctacag     4620

aattttccct cttggtgtga ttgcacagaa tttgtatgta ttttcagtta caagattgta     4680

agtaaattgc ctgatttgtt ttcattatag acaacgatga atttcttcta attatttaaa     4740

taaaatcacc aaaaacataa acattttatt gtatgcctga ttaagtagtt aattatagtc     4800

taaggcagta ctagagttga accaaaatga tttgtcaagc ttgctgatgt ttctgttttt     4860

cgtttttttt ttttttccgg agagaggata ggatctcact ctgttatcca ggctggagtg     4920

tgcaatggca caatcatagc tcagtgcagc ctcaaactcc tgggctcaag caatcctcct     4980

gcctcagcct cccgagtaac taggaccaca ggcacaggcc accatgcctg gctaaggttt     5040

ttatttttat tttttgtaga catggggatc acacaatgtt gcccaggctg gtcttgaact     5100

cctggcctca agcaaggtcg tgctggtaat tttgcaaaat gaattgtgat tgactttcag     5160

cctcccaacg tattagatta taggcattag ccatggtgcc cagccttgta acttttaaaa     5220

aaatttttta atctacaact ctgtagatta aaatttcaca tggtgttcta attaaatatt     5280

tttcttgcag ccaagatatt gttactacag ataacacaac ctgatatggt aactttaaat     5340

tttgggggct ttgaatcatt cagtttatgc attaactagt ccctttgttt atctttcatt     5400

tctcaacccc ttgtactttg gtgataccag acatcagaat aaaaagaaat tgaagtaaaa     5460

aaaaaaaaaa aaaa                                                       5474


<210>  184
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala Gly Ser Val Lys Arg Pro Met Ala Arg Arg Pro Ala Cys Phe 
1               5                   10                  15      


Thr Gly Gln Asn Cys Glu Glu Asn Ile Asp Asp Cys Pro Gly Asn Asn 
            20                  25                  30          


Cys Lys Asn Gly Gly Ala Cys Val Asp Gly Val Asn Thr Tyr Asn Cys 
        35                  40                  45              


Arg Cys Pro Pro Glu Trp Thr Gly Gln Tyr Cys Thr Glu Asp Val Asp 
    50                  55                  60                  


Glu Cys Gln Leu Met Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys His 
65                  70                  75                  80  


Asn Thr His Gly Gly Tyr Asn Cys Val Cys Val Asn Gly Trp Thr Gly 
                85                  90                  95      


Glu Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala Ser Ala Ala Cys Phe 
            100                 105                 110         


His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe Tyr Cys Glu Cys 
        115                 120                 125             


Pro His Gly Arg Thr Gly Leu Leu Cys His Leu Asn Asp Ala Cys Ile 
    130                 135                 140                 


Ser Asn Pro Cys Asn Glu Gly Ser Asn Cys Asp Thr Asn Pro Val Asn 
145                 150                 155                 160 


Gly Lys Ala Ile Cys Thr Cys Pro Ser Gly Tyr Thr Gly Pro Ala Cys 
                165                 170                 175     


Ser Gln Asp Val Asp Glu Cys Ser Leu Gly Ala Asn Pro Cys Glu His 
            180                 185                 190         


Ala Gly Lys Cys Ile Asn Thr Leu Gly Ser Phe Glu Cys Gln Cys Leu 
        195                 200                 205             


Gln Gly Tyr Thr Gly Pro Arg Cys Glu Ile Asp Val Asn Glu Cys Val 
    210                 215                 220                 


Ser Asn Pro Cys Gln Asn Asp Ala Thr Cys Leu Asp Gln Ile Gly Glu 
225                 230                 235                 240 


Phe Gln Cys Ile Cys Met Pro Gly Tyr Glu Gly Val His Cys Glu Val 
                245                 250                 255     


Asn Thr Asp Glu Cys Ala Ser Ser Pro Cys Leu His Asn Gly Arg Cys 
            260                 265                 270         


Leu Asp Lys Ile Asn Glu Phe Gln Cys Glu Cys Pro Thr Gly Phe Thr 
        275                 280                 285             


Gly His Leu Cys Gln Tyr Asp Val Asp Glu Cys Ala Ser Thr Pro Cys 
    290                 295                 300                 


Lys Asn Gly Ala Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val 
305                 310                 315                 320 


Cys Thr Glu Gly Tyr Thr Gly Thr His Cys Glu Val Asp Ile Asp Glu 
                325                 330                 335     


Cys Asp Pro Asp Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala 
            340                 345                 350         


Thr Phe Thr Cys Leu Cys Arg Pro Gly Tyr Thr Gly His His Cys Glu 
        355                 360                 365             


Thr Asn Ile Asn Glu Cys Ser Ser Gln Pro Cys Arg His Gly Gly Thr 
    370                 375                 380                 


Cys Gln Asp Arg Asp Asn Ala Tyr Leu Cys Phe Cys Leu Lys Gly Thr 
385                 390                 395                 400 


Thr Gly Pro Asn Cys Glu Ile Asn Leu Asp Asp Cys Ala Ser Ser Pro 
                405                 410                 415     


Cys Asp Ser Gly Thr Cys Leu Asp Lys Ile Asp Gly Tyr Glu Cys Ala 
            420                 425                 430         


Cys Glu Pro Gly Tyr Thr Gly Ser Met Cys Asn Ile Asn Ile Asp Glu 
        435                 440                 445             


Cys Ala Gly Asn Pro Cys His Asn Gly Gly Thr Cys Glu Asp Gly Ile 
    450                 455                 460                 


Asn Gly Phe Thr Cys Arg Cys Pro Glu Gly Tyr His Asp Pro Thr Cys 
465                 470                 475                 480 


Leu Ser Glu Val Asn Glu Cys Asn Ser Asn Pro Cys Val His Gly Ala 
                485                 490                 495     


Cys Arg Asp Ser Leu Asn Gly Tyr Lys Cys Asp Cys Asp Pro Gly Trp 
            500                 505                 510         


Ser Gly Thr Asn Cys Asp Ile Asn Asn Asn Glu Cys Glu Ser Asn Pro 
        515                 520                 525             


Cys Val Asn Gly Gly Thr Cys Lys Asp Met Thr Ser Gly Tyr Val Cys 
    530                 535                 540                 


Thr Cys Arg Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr Asn Ile Asn 
545                 550                 555                 560 


Glu Cys Ala Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Ile Asp Asp 
                565                 570                 575     


Val Ala Gly Tyr Lys Cys Asn Cys Leu Leu Pro Tyr Thr Gly Ala Thr 
            580                 585                 590         


Cys Glu Val Val Leu Ala Pro Cys Ala Pro Ser Pro Cys Arg Asn Gly 
        595                 600                 605             


Gly Glu Cys Arg Gln Ser Glu Asp Tyr Glu Ser Phe Ser Cys Val Cys 
    610                 615                 620                 


Pro Thr Gly Trp Gln Gly Gln Thr Cys Glu Val Asp Ile Asn Glu Cys 
625                 630                 635                 640 


Val Leu Ser Pro Cys Arg His Gly Ala Ser Cys Gln Asn Thr His Gly 
                645                 650                 655     


Gly Tyr Arg Cys His Cys Gln Ala Gly Tyr Ser Gly Arg Asn Cys Glu 
            660                 665                 670         


Thr Asp Ile Asp Asp Cys Arg Pro Asn Pro Cys His Asn Gly Gly Ser 
        675                 680                 685             


Cys Thr Asp Gly Ile Asn Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe 
    690                 695                 700                 


Arg Gly Thr Phe Cys Glu Glu Asp Ile Asn Glu Cys Ala Ser Asp Pro 
705                 710                 715                 720 


Cys Arg Asn Gly Ala Asn Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys 
                725                 730                 735     


Thr Cys Pro Ala Gly Phe Ser Gly Ile His Cys Glu Asn Asn Thr Pro 
            740                 745                 750         


Asp Cys Thr Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly 
        755                 760                 765             


Ile Asn Ser Phe Thr Cys Leu Cys Pro Pro Gly Phe Thr Gly Ser Tyr 
    770                 775                 780                 


Cys Gln His Asp Val Asn Glu Cys Asp Ser Gln Pro Cys Leu His Gly 
785                 790                 795                 800 


Gly Thr Cys Gln Asp Gly Cys Gly Ser Tyr Arg Cys Thr Cys Pro Gln 
                805                 810                 815     


Gly Tyr Thr Gly Pro Asn Cys Gln Asn Leu Val His Trp Cys Asp Ser 
            820                 825                 830         


Ser Pro Cys Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr Gln Tyr 
        835                 840                 845             


Arg Cys Glu Cys Pro Ser Gly Trp Thr Gly Leu Tyr Cys Asp Val Pro 
    850                 855                 860                 


Ser Val Ser Cys Glu Val Ala Ala Gln Arg Gln Gly Val Asp Val Ala 
865                 870                 875                 880 


Arg Leu Cys Gln His Gly Gly Leu Cys Val Asp Ala Gly Asn Thr His 
                885                 890                 895     


His Cys Arg Cys Gln Ala Gly Tyr Thr Gly Ser Tyr Cys Glu Asp Leu 
            900                 905                 910         


Val Asp Glu Cys Ser Pro Ser Pro Cys Gln Asn Gly Ala Thr Cys Thr 
        915                 920                 925             


Asp Tyr Leu Gly Gly Tyr Ser Cys Lys Cys Val Ala Gly Tyr His Gly 
    930                 935                 940                 


Val Asn Cys Ser Glu Glu Ile Asp Glu Cys Leu Ser His Pro Cys Gln 
945                 950                 955                 960 


Asn Gly Gly Thr Cys Leu Asp Leu Pro Asn Thr Tyr Lys Cys Ser Cys 
                965                 970                 975     


Pro Arg Gly Thr Gln Gly Val His Cys Glu Ile Asn Val Asp Asp Cys 
            980                 985                 990         


Asn Pro Pro Val Asp Pro Val Ser  Arg Ser Pro Lys Cys  Phe Asn Asn 
        995                 1000                 1005             


Gly Thr  Cys Val Asp Gln Val  Gly Gly Tyr Ser Cys  Thr Cys Pro 
    1010                 1015                 1020             


Pro Gly  Phe Val Gly Glu Arg  Cys Glu Gly Asp Val  Asn Glu Cys 
    1025                 1030                 1035             


Leu Ser  Asn Pro Cys Asp Ala  Arg Gly Thr Gln Asn  Cys Val Gln 
    1040                 1045                 1050             


Arg Val  Asn Asp Phe His Cys  Glu Cys Arg Ala Gly  His Thr Gly 
    1055                 1060                 1065             


Arg Arg  Cys Glu Ser Val Ile  Asn Gly Cys Lys Gly  Lys Pro Cys 
    1070                 1075                 1080             


Lys Asn  Gly Gly Thr Cys Ala  Val Ala Ser Asn Thr  Ala Arg Gly 
    1085                 1090                 1095             


Phe Ile  Cys Lys Cys Pro Ala  Gly Phe Glu Gly Ala  Thr Cys Glu 
    1100                 1105                 1110             


Asn Asp  Ala Arg Thr Cys Gly  Ser Leu Arg Cys Leu  Asn Gly Gly 
    1115                 1120                 1125             


Thr Cys  Ile Ser Gly Pro Arg  Ser Pro Thr Cys Leu  Cys Leu Gly 
    1130                 1135                 1140             


Pro Phe  Thr Gly Pro Glu Cys  Gln Phe Pro Ala Ser  Ser Pro Cys 
    1145                 1150                 1155             


Leu Gly  Gly Asn Pro Cys Tyr  Asn Gln Gly Thr Cys  Glu Pro Thr 
    1160                 1165                 1170             


Ser Glu  Ser Pro Phe Tyr Arg  Cys Leu Cys Pro Ala  Lys Phe Asn 
    1175                 1180                 1185             


Gly Leu  Leu Cys His Ile Leu  Asp Tyr Ser Phe Gly  Gly Gly Ala 
    1190                 1195                 1200             


Gly Arg  Asp Ile Pro Pro Pro  Leu Ile Glu Glu Ala  Cys Glu Leu 
    1205                 1210                 1215             


Pro Glu  Cys Gln Glu Asp Ala  Gly Asn Lys Val Cys  Ser Leu Gln 
    1220                 1225                 1230             


Cys Asn  Asn His Ala Cys Gly  Trp Asp Gly Gly Asp  Cys Ser Leu 
    1235                 1240                 1245             


Asn Phe  Asn Asp Pro Trp Lys  Asn Cys Thr Gln Ser  Leu Gln Cys 
    1250                 1255                 1260             


Trp Lys  Tyr Phe Ser Asp Gly  His Cys Asp Ser Gln  Cys Asn Ser 
    1265                 1270                 1275             


Ala Gly  Cys Leu Phe Asp Gly  Phe Asp Cys Gln Arg  Ala Glu Gly 
    1280                 1285                 1290             


Gln Cys  Asn Pro Leu Tyr Asp  Gln Tyr Cys Lys Asp  His Phe Ser 
    1295                 1300                 1305             


Asp Gly  His Cys Asp Gln Gly  Cys Asn Ser Ala Glu  Cys Glu Trp 
    1310                 1315                 1320             


Asp Gly  Leu Asp Cys Ala Glu  His Val Pro Glu Arg  Leu Ala Ala 
    1325                 1330                 1335             


Gly Thr  Leu Val Val Val Val  Leu Met Pro Pro Glu  Gln Leu Arg 
    1340                 1345                 1350             


Asn Ser  Ser Phe His Phe Leu  Arg Glu Leu Ser Arg  Val Leu His 
    1355                 1360                 1365             


Thr Asn  Val Val Phe Lys Arg  Asp Ala His Gly Gln  Gln Met Ile 
    1370                 1375                 1380             


Phe Pro  Tyr Tyr Gly Arg Glu  Glu Glu Leu Arg Lys  His Pro Ile 
    1385                 1390                 1395             


Lys Arg  Ala Ala Glu Gly Trp  Ala Ala Pro Asp Ala  Leu Leu Gly 
    1400                 1405                 1410             


Gln Val  Lys Ala Ser Leu Leu  Pro Gly Gly Ser Glu  Gly Gly Arg 
    1415                 1420                 1425             


Arg Arg  Arg Glu Leu Asp Pro  Met Asp Val Arg Gly  Ser Ile Val 
    1430                 1435                 1440             


Tyr Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Ala  Ser Ser Gln 
    1445                 1450                 1455             


Cys Phe  Gln Ser Ala Thr Asp  Val Ala Ala Phe Leu  Gly Ala Leu 
    1460                 1465                 1470             


Ala Ser  Leu Gly Ser Leu Asn  Ile Pro Tyr Lys Ile  Glu Ala Val 
    1475                 1480                 1485             


Gln Ser  Glu Thr Val Glu Pro  Pro Pro Pro Ala Gln  Leu His Phe 
    1490                 1495                 1500             


Met Tyr  Val Ala Ala Ala Ala  Phe Val Leu Leu Phe  Phe Val Gly 
    1505                 1510                 1515             


Cys Gly  Val Leu Leu Ser Arg  Lys Arg Arg Arg Gln  His Gly Gln 
    1520                 1525                 1530             


Leu Trp  Phe Pro Glu Gly Phe  Lys Val Ser Glu Ala  Ser Lys Lys 
    1535                 1540                 1545             


Lys Arg  Arg Glu Pro Leu Gly  Glu Asp Ser Val Gly  Leu Lys Pro 
    1550                 1555                 1560             


Leu Lys  Asn Ala Ser Asp Gly  Ala Leu Met Asp Asp  Asn Gln Asn 
    1565                 1570                 1575             


Glu Trp  Gly Asp Glu Asp Leu  Glu Thr Lys Lys Phe  Arg Phe Glu 
    1580                 1585                 1590             


Glu Pro  Val Val Leu Pro Asp  Leu Asp Asp Gln Thr  Asp His Arg 
    1595                 1600                 1605             


Gln Trp  Thr Gln Gln His Leu  Asp Ala Ala Asp Leu  Arg Met Ser 
    1610                 1615                 1620             


Ala Met  Ala Pro Thr Pro Pro  Gln Gly Glu Val Asp  Ala Asp Cys 
    1625                 1630                 1635             


Met Asp  Val Asn Val Arg Gly  Pro Asp Gly Phe Thr  Pro Leu Met 
    1640                 1645                 1650             


Ile Ala  Ser Cys Ser Gly Gly  Gly Leu Glu Thr Gly  Asn Ser Glu 
    1655                 1660                 1665             


Glu Glu  Glu Asp Ala Pro Ala  Val Ile Ser Asp Phe  Ile Tyr Gln 
    1670                 1675                 1680             


Gly Ala  Ser Leu His Asn Gln  Thr Asp Arg Thr Gly  Glu Thr Ala 
    1685                 1690                 1695             


Leu His  Leu Ala Ala Arg Tyr  Ser Arg Ser Asp Ala  Ala Lys Arg 
    1700                 1705                 1710             


Leu Leu  Glu Ala Ser Ala Asp  Ala Asn Ile Gln Asp  Asn Met Gly 
    1715                 1720                 1725             


Arg Thr  Pro Leu His Ala Ala  Val Ser Ala Asp Ala  Gln Gly Val 
    1730                 1735                 1740             


Phe Gln  Ile Leu Ile Arg Asn  Arg Ala Thr Asp Leu  Asp Ala Arg 
    1745                 1750                 1755             


Met His  Asp Gly Thr Thr Pro  Leu Ile Leu Ala Ala  Arg Leu Ala 
    1760                 1765                 1770             


Val Glu  Gly Met Leu Glu Asp  Leu Ile Asn Ser His  Ala Asp Val 
    1775                 1780                 1785             


Asn Ala  Val Asp Asp Leu Gly  Lys Ser Ala Leu His  Trp Ala Ala 
    1790                 1795                 1800             


Ala Val  Asn Asn Val Asp Ala  Ala Val Val Leu Leu  Lys Asn Gly 
    1805                 1810                 1815             


Ala Asn  Lys Asp Met Gln Asn  Asn Arg Glu Glu Thr  Pro Leu Phe 
    1820                 1825                 1830             


Leu Ala  Ala Arg Glu Gly Ser  Tyr Glu Thr Ala Lys  Val Leu Leu 
    1835                 1840                 1845             


Asp His  Phe Ala Asn Arg Asp  Ile Thr Asp His Met  Asp Arg Leu 
    1850                 1855                 1860             


Pro Arg  Asp Ile Ala Gln Glu  Arg Met His His Asp  Ile Val Arg 
    1865                 1870                 1875             


Leu Leu  Asp Glu Tyr Asn Leu  Val Arg Ser Pro Gln  Leu His Gly 
    1880                 1885                 1890             


Ala Pro  Leu Gly Gly Thr Pro  Thr Leu Ser Pro Pro  Leu Cys Ser 
    1895                 1900                 1905             


Pro Asn  Gly Tyr Leu Gly Ser  Leu Lys Pro Gly Val  Gln Gly Lys 
    1910                 1915                 1920             


Lys Val  Arg Lys Pro Ser Ser  Lys Gly Leu Ala Cys  Gly Ser Lys 
    1925                 1930                 1935             


Glu Ala  Lys Asp Leu Lys Ala  Arg Arg Lys Lys Ser  Gln Asp Gly 
    1940                 1945                 1950             


Lys Gly  Cys Leu Leu Asp Ser  Ser Gly Met Leu Ser  Pro Val Asp 
    1955                 1960                 1965             


Ser Leu  Glu Ser Pro His Gly  Tyr Leu Ser Asp Val  Ala Ser Pro 
    1970                 1975                 1980             


Pro Leu  Leu Pro Ser Pro Phe  Gln Gln Ser Pro Ser  Val Pro Leu 
    1985                 1990                 1995             


Asn His  Leu Pro Gly Met Pro  Asp Thr His Leu Gly  Ile Gly His 
    2000                 2005                 2010             


Leu Asn  Val Ala Ala Lys Pro  Glu Met Ala Ala Leu  Gly Gly Gly 
    2015                 2020                 2025             


Gly Arg  Leu Ala Phe Glu Thr  Gly Pro Pro Arg Leu  Ser His Leu 
    2030                 2035                 2040             


Pro Val  Ala Ser Gly Thr Ser  Thr Val Leu Gly Ser  Ser Ser Gly 
    2045                 2050                 2055             


Gly Ala  Leu Asn Phe Thr Val  Gly Gly Ser Thr Ser  Leu Asn Gly 
    2060                 2065                 2070             


Gln Cys  Glu Trp Leu Ser Arg  Leu Gln Ser Gly Met  Val Pro Asn 
    2075                 2080                 2085             


Gln Tyr  Asn Pro Leu Arg Gly  Ser Val Ala Pro Gly  Pro Leu Ser 
    2090                 2095                 2100             


Thr Gln  Ala Pro Ser Leu Gln  His Gly Met Val Gly  Pro Leu His 
    2105                 2110                 2115             


Ser Ser  Leu Ala Ala Ser Ala  Leu Ser Gln Met Met  Ser Tyr Gln 
    2120                 2125                 2130             


Gly Leu  Pro Ser Thr Arg Leu  Ala Thr Gln Pro His  Leu Val Gln 
    2135                 2140                 2145             


Thr Gln  Gln Val Gln Pro Gln  Asn Leu Gln Met Gln  Gln Gln Asn 
    2150                 2155                 2160             


Leu Gln  Pro Ala Asn Ile Gln  Gln Gln Gln Ser Leu  Gln Pro Pro 
    2165                 2170                 2175             


Pro Pro  Pro Pro Gln Pro His  Leu Gly Val Ser Ser  Ala Ala Ser 
    2180                 2185                 2190             


Gly His  Leu Gly Arg Ser Phe  Leu Ser Gly Glu Pro  Ser Gln Ala 
    2195                 2200                 2205             


Asp Val  Gln Pro Leu Gly Pro  Ser Ser Leu Ala Val  His Thr Ile 
    2210                 2215                 2220             


Leu Pro  Gln Glu Ser Pro Ala  Leu Pro Thr Ser Leu  Pro Ser Ser 
    2225                 2230                 2235             


Leu Val  Pro Pro Val Thr Ala  Ala Gln Phe Leu Thr  Pro Pro Ser 
    2240                 2245                 2250             


Gln His  Ser Tyr Ser Ser Pro  Val Asp Asn Thr Pro  Ser His Gln 
    2255                 2260                 2265             


Leu Gln  Val Pro Glu His Pro  Phe Leu Thr Pro Ser  Pro Glu Ser 
    2270                 2275                 2280             


Pro Asp  Gln Trp Ser Ser Ser  Ser Pro His Ser Asn  Val Ser Asp 
    2285                 2290                 2295             


Trp Ser  Glu Gly Val Ser Ser  Pro Pro Thr Ser Met  Gln Ser Gln 
    2300                 2305                 2310             


Ile Ala  Arg Ile Pro Glu Ala  Phe Lys 
    2315                 2320         


<210>  185
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  186
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Met  Lys Ser Ser Leu Ser  Ile Phe His Pro Gly  His Cys Leu 
    1220                 1225                 1230             


Lys Leu  
    1235 


<210>  187
<211>  2321
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro 
        35                  40                  45              


Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala 
    50                  55                  60                  


Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp 
65                  70                  75                  80  


Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser 
                85                  90                  95      


Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe 
            100                 105                 110         


Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys 
        115                 120                 125             


Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys 
    130                 135                 140                 


Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp 
145                 150                 155                 160 


Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn 
                165                 170                 175     


Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro 
            180                 185                 190         


Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
        195                 200                 205             


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
    210                 215                 220                 


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
225                 230                 235                 240 


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
                245                 250                 255     


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
            260                 265                 270         


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
        275                 280                 285             


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
    290                 295                 300                 


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
305                 310                 315                 320 


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
                325                 330                 335     


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
            340                 345                 350         


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
        355                 360                 365             


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
    370                 375                 380                 


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
385                 390                 395                 400 


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
                405                 410                 415     


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
            420                 425                 430         


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
        435                 440                 445             


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
    450                 455                 460                 


Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn 
465                 470                 475                 480 


Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro 
                485                 490                 495     


Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala 
            500                 505                 510         


Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly 
        515                 520                 525             


Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg 
    530                 535                 540                 


Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val 
545                 550                 555                 560 


Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly 
                565                 570                 575     


Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg 
            580                 585                 590         


His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys 
        595                 600                 605             


Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys 
    610                 615                 620                 


Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg 
625                 630                 635                 640 


Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val 
                645                 650                 655     


Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys 
            660                 665                 670         


Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu 
        675                 680                 685             


Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys 
    690                 695                 700                 


Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys 
705                 710                 715                 720 


Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp 
                725                 730                 735     


Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp 
            740                 745                 750         


Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln 
        755                 760                 765             


Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly 
    770                 775                 780                 


Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln 
785                 790                 795                 800 


Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly 
                805                 810                 815     


Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser 
            820                 825                 830         


Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln 
        835                 840                 845             


Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys 
    850                 855                 860                 


Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala 
865                 870                 875                 880 


Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys 
                885                 890                 895     


Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys 
            900                 905                 910         


Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys 
        915                 920                 925             


Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    930                 935                 940                 


Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln 
945                 950                 955                 960 


His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val 
                965                 970                 975     


Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe 
            980                 985                 990         


Thr Gly Pro Gln Cys Gln Thr Leu  Val Asp Trp Cys Ser  Arg Gln Pro 
        995                 1000                 1005             


Cys Gln  Asn Gly Gly Arg Cys  Val Gln Thr Gly Ala  Tyr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Gly Trp Ser Gly  Arg Leu Cys Asp Ile  Arg Ser Leu 
    1025                 1030                 1035             


Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly Val Arg  Leu Glu Gln 
    1040                 1045                 1050             


Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp Glu Asp  Ser Ser His 
    1055                 1060                 1065             


Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly Ser His  Cys Glu Gln 
    1070                 1075                 1080             


Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys Gln His  Gly Gly Thr 
    1085                 1090                 1095             


Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys Glu Cys  Leu Pro Gly 
    1100                 1105                 1110             


Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val Asp Glu  Cys Ala Ser 
    1115                 1120                 1125             


Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile Asp Leu  Val Ala Arg 
    1130                 1135                 1140             


Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu Gly Val  Leu Cys Glu 
    1145                 1150                 1155             


Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro Pro Leu  Asp Ser Gly 
    1160                 1165                 1170             


Pro Arg  Cys Leu His Asn Gly  Thr Cys Val Asp Leu  Val Gly Gly 
    1175                 1180                 1185             


Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr Gly Leu  Arg Cys Glu 
    1190                 1195                 1200             


Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala Cys His  Ala Ala His 
    1205                 1210                 1215             


Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly Gly Phe  Arg Cys Leu 
    1220                 1225                 1230             


Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys Gln Thr  Val Leu Ser 
    1235                 1240                 1245             


Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly Gly Gln  Cys Arg Pro 
    1250                 1255                 1260             


Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe Thr Cys  His Cys Ala 
    1265                 1270                 1275             


Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg Val Ala  Arg Ser Cys 
    1280                 1285                 1290             


Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro Cys Gln  Gln Thr Pro 
    1295                 1300                 1305             


Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly Leu Ser  Gly Pro Ser 
    1310                 1315                 1320             


Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly Ala Ser  Asn Ala Ser 
    1325                 1330                 1335             


Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly Ser Cys  Arg Pro Ala 
    1340                 1345                 1350             


Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys Ala Gln  Gly Trp Thr 
    1355                 1360                 1365             


Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala Pro Glu  Val Ser Glu 
    1370                 1375                 1380             


Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln Ala Lys  Arg Gly Asp 
    1385                 1390                 1395             


Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro Gly Cys  Gly Trp Asp 
    1400                 1405                 1410             


Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp Pro Trp  Arg Gln Cys 
    1415                 1420                 1425             


Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn Asn Ser  Arg Cys Asp 
    1430                 1435                 1440             


Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr Asp Asn  Phe Asp Cys 
    1445                 1450                 1455             


His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn Pro Val  Tyr Glu Lys 
    1460                 1465                 1470             


Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg Cys Asp  Gln Gly Cys 
    1475                 1480                 1485             


Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu Asp Cys  Ala Ser Glu 
    1490                 1495                 1500             


Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu Val Leu  Thr Val Leu 
    1505                 1510                 1515             


Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser Ala Asp  Phe Leu Gln 
    1520                 1525                 1530             


Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu Arg Phe  Arg Leu Asp 
    1535                 1540                 1545             


Ala His  Gly Gln Ala Met Val  Phe Pro Tyr His Arg  Pro Ser Pro 
    1550                 1555                 1560             


Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu Ala Pro  Glu Val Ile 
    1565                 1570                 1575             


Gly Ser  Val Val Met Leu Glu  Ile Asp Asn Arg Leu  Cys Leu Gln 
    1580                 1585                 1590             


Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp Ala Gln  Ser Ala Ala 
    1595                 1600                 1605             


Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu Arg Leu  Asp Phe Pro 
    1610                 1615                 1620             


Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro Leu Glu  Pro Pro Glu 
    1625                 1630                 1635             


Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val Ala Gly  Ala Val Leu 
    1640                 1645                 1650             


Leu Leu  Val Ile Leu Val Leu  Gly Val Met Val Ala  Arg Arg Lys 
    1655                 1660                 1665             


Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu Gly Phe  Ser Leu His 
    1670                 1675                 1680             


Lys Asp  Val Ala Ser Gly His  Lys Gly Arg Arg Glu  Pro Val Gly 
    1685                 1690                 1695             


Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala Lys Gly  Glu Ser Leu 
    1700                 1705                 1710             


Met Gly  Glu Val Ala Thr Asp  Trp Met Asp Thr Glu  Cys Pro Glu 
    1715                 1720                 1725             


Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly Met Gly  Ala Glu Glu 
    1730                 1735                 1740             


Ala Val  Asp Cys Arg Gln Trp  Thr Gln His His Leu  Val Ala Ala 
    1745                 1750                 1755             


Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu Thr Pro  Pro Gln Gly 
    1760                 1765                 1770             


Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn Val Arg  Gly Pro Asp 
    1775                 1780                 1785             


Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe Cys Gly  Gly Ala Leu 
    1790                 1795                 1800             


Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala Asp Asp  Thr Ser Ala 
    1805                 1810                 1815             


Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly Ala Gln  Leu Gly Ala 
    1820                 1825                 1830             


Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1835                 1840                 1845             


Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu Leu Asp  Ala Gly Ala 
    1850                 1855                 1860             


Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg Thr Pro  Leu His Thr 
    1865                 1870                 1875             


Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1880                 1885                 1890             


Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met Ala Asp  Gly Ser Thr 
    1895                 1900                 1905             


Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Val Glu 
    1910                 1915                 1920             


Glu Leu  Ile Ala Ser His Ala  Asp Val Asn Ala Val  Asp Glu Leu 
    1925                 1930                 1935             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Glu 
    1940                 1945                 1950             


Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    1955                 1960                 1965             


Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    1970                 1975                 1980             


Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp His Phe  Ala Asn Arg 
    1985                 1990                 1995             


Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro Arg Asp  Val Ala Gln 
    2000                 2005                 2010             


Glu Arg  Leu His Gln Asp Ile  Val Arg Leu Leu Asp  Gln Pro Ser 
    2015                 2020                 2025             


Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly Leu Gly  Pro Leu Leu 
    2030                 2035                 2040             


Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu Lys Ala  Ala Gln Ser 
    2045                 2050                 2055             


Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly Lys Ala  Gly Leu Gly 
    2060                 2065                 2070             


Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys Leu Thr  Leu Ala Cys 
    2075                 2080                 2085             


Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr Leu Ser  Pro Val Asp 
    2090                 2095                 2100             


Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly Pro Pro  Ala Ser Pro 
    2105                 2110                 2115             


Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala Ala Ala  Thr Ala Thr 
    2120                 2125                 2130             


Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro Gly Arg  Ala Gly Leu 
    2135                 2140                 2145             


Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu Ser Leu  Gly Leu Leu 
    2150                 2155                 2160             


Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala Arg Leu  Pro Pro Pro 
    2165                 2170                 2175             


Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro Leu Ala  Pro Gly Pro 
    2180                 2185                 2190             


Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser Pro Gln  Glu Arg Pro 
    2195                 2200                 2205             


Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly Glu Glu  Tyr Pro Ala 
    2210                 2215                 2220             


Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala Arg Phe  Leu Arg Val 
    2225                 2230                 2235             


Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser Pro Glu  Ser Pro Glu 
    2240                 2245                 2250             


His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu Ser Asp  Trp Ser Glu 
    2255                 2260                 2265             


Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly Ala Met  Ala Thr Thr 
    2270                 2275                 2280             


Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro Leu Ser  Val Pro Ser 
    2285                 2290                 2295             


Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly Pro Gln  Pro Glu Val 
    2300                 2305                 2310             


Thr Pro  Lys Arg Gln Val Leu  Ala 
    2315                 2320     


<210>  188
<211>  2003
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  189
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys 
            20                  25                  30          


Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile 
        35                  40                  45              


Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr 
65                  70                  75                  80  


Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg 
                85                  90                  95      


Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser 
            100                 105                 110         


Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp 
        115                 120                 125             


Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg 
    130                 135                 140                 


Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met 
145                 150                 155                 160 


Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu 
                165                 170                 175     


Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala 
            180                 185                 190         


Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu 
        195                 200                 205             


Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val 
    210                 215                 220                 


Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr 
225                 230                 235                 240 


Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu 
                245                 250                 255     


Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu 
            260                 265                 270         


Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser 
        275                 280                 285             


Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu 
    290                 295                 300                 


Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu 
305                 310                 315                 320 


Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly 
            340                 345                 350         


Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu 
        355                 360                 365             


Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His 
    370                 375                 380                 


Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr 
                405                 410                 415     


Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile 
            420                 425                 430         


His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp 
        435                 440                 445             


Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
    450                 455                 460         


<210>  190
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr Gln His Cys 
            180                 185                 190         


Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala Pro Leu Gln 
        195                 200                 205             


Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr 
    210                 215                 220                 


Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln Ser Phe Ser 
225                 230                 235                 240 


Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr Pro Arg Gly 
                245                 250                 255     


Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser Pro His Ser 
            260                 265                 270         


Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala Asp Asp Lys 
        275                 280                 285             


Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr Tyr Trp Glu 
    290                 295                 300                 


Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly Thr Gly Ser 
305                 310                 315                 320 


Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val Ala Val Lys 
                325                 330                 335     


Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln Ala Phe Lys 
            340                 345                 350         


Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn Ile Leu Leu 
        355                 360                 365             


Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile Thr Gln Trp 
    370                 375                 380                 


Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala Asp Thr Arg 
385                 390                 395                 400 


Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr Ala Gln Gly 
                405                 410                 415     


Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp Leu Lys Ser 
            420                 425                 430         


Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile Gly Asp Phe 
        435                 440                 445             


Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln Pro Leu Glu 
    450                 455                 460                 


Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val Ile Arg Met 
465                 470                 475                 480 


Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Tyr Gly 
                485                 490                 495     


Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr Ser His Ile 
            500                 505                 510         


Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser 
        515                 520                 525             


Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala Met Arg Arg 
    530                 535                 540                 


Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg Pro Leu Phe 
545                 550                 555                 560 


Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser Leu Pro Lys 
                565                 570                 575     


Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr Gln Ala Asp 
            580                 585                 590         


Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val Pro 
        595                 600                 605     


<210>  191
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Pro Ser Arg Phe Tyr His Ser 
145                 150                 155                 160 


Val Gln Asp Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn 
                165                 170                 175     


Arg Pro Leu Asn Glu Leu Leu Thr Pro Gln Gly Pro Ser Pro Arg Thr 
            180                 185                 190         


Gln His Cys Asp Pro Glu His Phe Pro Phe Pro Ala Pro Ala Asn Ala 
        195                 200                 205             


Pro Leu Gln Arg Ile Arg Ser Thr Ser Thr Pro Asn Val His Met Val 
    210                 215                 220                 


Ser Thr Thr Ala Pro Met Asp Ser Asn Leu Ile Gln Leu Thr Gly Gln 
225                 230                 235                 240 


Ser Phe Ser Thr Asp Ala Ala Gly Ser Arg Gly Gly Ser Asp Gly Thr 
                245                 250                 255     


Pro Arg Gly Ser Pro Ser Pro Ala Ser Val Ser Ser Gly Arg Lys Ser 
            260                 265                 270         


Pro His Ser Lys Ser Pro Ala Glu Gln Arg Glu Arg Lys Ser Leu Ala 
        275                 280                 285             


Asp Asp Lys Lys Lys Val Lys Asn Leu Gly Tyr Arg Asp Ser Gly Tyr 
    290                 295                 300                 


Tyr Trp Glu Val Pro Pro Ser Glu Val Gln Leu Leu Lys Arg Ile Gly 
305                 310                 315                 320 


Thr Gly Ser Phe Gly Thr Val Phe Arg Gly Arg Trp His Gly Asp Val 
                325                 330                 335     


Ala Val Lys Val Leu Lys Val Ser Gln Pro Thr Ala Glu Gln Ala Gln 
            340                 345                 350         


Ala Phe Lys Asn Glu Met Gln Val Leu Arg Lys Thr Arg His Val Asn 
        355                 360                 365             


Ile Leu Leu Phe Met Gly Phe Met Thr Arg Pro Gly Phe Ala Ile Ile 
    370                 375                 380                 


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Val Ala 
385                 390                 395                 400 


Asp Thr Arg Phe Asp Met Val Gln Leu Ile Asp Val Ala Arg Gln Thr 
                405                 410                 415     


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile Ile His Arg Asp 
            420                 425                 430         


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu Thr Val Lys Ile 
        435                 440                 445             


Gly Asp Phe Gly Leu Ala Thr Val Lys Thr Arg Trp Ser Gly Ala Gln 
    450                 455                 460                 


Pro Leu Glu Gln Pro Ser Gly Ser Val Leu Trp Met Ala Ala Glu Val 
465                 470                 475                 480 


Ile Arg Met Gln Asp Pro Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
                485                 490                 495     


Ala Tyr Gly Val Val Leu Tyr Glu Leu Met Thr Gly Ser Leu Pro Tyr 
            500                 505                 510         


Ser His Ile Gly Cys Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
        515                 520                 525             


Tyr Leu Ser Pro Asp Leu Ser Lys Ile Ser Ser Asn Cys Pro Lys Ala 
    530                 535                 540                 


Met Arg Arg Leu Leu Ser Asp Cys Leu Lys Phe Gln Arg Glu Glu Arg 
545                 550                 555                 560 


Pro Leu Phe Pro Gln Ile Leu Ala Thr Ile Glu Leu Leu Gln Arg Ser 
                565                 570                 575     


Leu Pro Lys Ile Glu Arg Ser Ala Ser Glu Pro Ser Leu His Arg Thr 
            580                 585                 590         


Gln Ala Asp Glu Leu Pro Ala Cys Leu Leu Ser Ala Ala Arg Leu Val 
        595                 600                 605             


Pro 
    


<210>  192
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Thr Pro Gln Gly Pro Arg 
            180                 185     


<210>  193
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  194
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
1               5                   10                  15      


Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
            20                  25                  30          


Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
        35                  40                  45              


Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
    50                  55                  60                  


Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
65                  70                  75                  80  


Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                85                  90                  95      


Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 
            100                 105                 110         


Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
        115                 120                 125             


Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
    130                 135                 140                 


Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 
145                 150                 155                 160 


Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 
                165                 170                 175     


Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 
            180                 185                 190         


Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala 
        195                 200                 205             


Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 
    210                 215                 220                 


Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 
225                 230                 235                 240 


Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 
                245                 250                 255     


Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 
            260                 265                 270         


Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 
        275                 280                 285             


Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 
    290                 295                 300                 


Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 
305                 310                 315                 320 


Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 
                325                 330                 335     


Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 
            340                 345                 350         


Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 
        355                 360                 365             


His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 
    370                 375                 380                 


Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 
385                 390                 395                 400 


Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 
                405                 410                 415     


Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 
            420                 425                 430         


Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 
        435                 440                 445             


Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 
    450                 455                 460                 


Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 
465                 470                 475                 480 


Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 
                485                 490                 495     


Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 
            500                 505                 510         


Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 
        515                 520                 525             


Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 
    530                 535                 540                 


Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 
545                 550                 555                 560 


Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn 
                565                 570                 575     


Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 
            580                 585                 590         


Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 
        595                 600                 605             


Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 
    610                 615                 620                 


Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 
625                 630                 635                 640 


Thr Ser Pro Arg Leu Pro Val Phe 
                645             


<210>  195
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  195
atgctgtccc cggacgatat tgaacaatgg ttcactgaag                             40


<210>  196
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  196
atgctgtccc cgtgagccac cgtgcccact gaag                                   34


<210>  197
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Ser Asn 
            420                 425                 430         


Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu Pro Leu 
        435                 440                 445             


Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser Glu Arg 
    450                 455                 460                 


Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu Leu Ser 
465                 470                 475                 480 


Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro Ser Ser 
                485                 490                 495     


Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg Met Val 
            500                 505                 510         


Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly Thr 
        515                 520                 525             


Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe His Lys 
    530                 535                 540                 


Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His Cys Gly 
545                 550                 555                 560 


Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly Asp Gly 
                565                 570                 575     


Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro Leu Ser 
            580                 585                 590         


Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala Arg Met 
        595                 600                 605             


Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu Ala Asp 
    610                 615                 620                 


Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly Gly Cys 
625                 630                 635                 640 


Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala Leu Glu 
                645                 650                 655     


Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu Arg Phe 
            660                 665                 670         


His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu Gln Lys 
        675                 680                 685             


Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln Ser Asp 
    690                 695                 700                 


Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser 
705                 710                 715                 720 


Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala 
                725                 730                 735     


Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn 
            740                 745                 750         


His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr 
        755                 760                 765             


Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile 
    770                 775                 780                 


Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp 
785                 790                 795                 800 


Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala 
                805                 810                 815     


Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala 
            820                 825                 830         


Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 
        835                 840                 845             


Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg 
    850                 855                 860                 


Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile 
865                 870                 875                 880 


Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg 
                885                 890                 895     


Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp 
            900                 905                 910         


Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg 
        915                 920                 925             


Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile 
    930                 935                 940                 


Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys 
945                 950                 955                 960 


Val Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile 
                965                 970                 975     


Ser Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr 
            980                 985                 990         


His Leu Gln His Cys Thr Cys Val  Asp Asp Cys Ser Ser  Ser Asn Cys 
        995                 1000                 1005             


Leu Cys  Gly Gln Leu Ser Ile  Arg Cys Trp Tyr Asp  Lys Asp Gly 
    1010                 1015                 1020             


Arg Leu  Leu Gln Glu Phe Asn  Lys Ile Glu Pro Pro  Leu Ile Phe 
    1025                 1030                 1035             


Glu Cys  Asn Gln Ala Cys Ser  Cys Trp Arg Asn Cys  Lys Asn Arg 
    1040                 1045                 1050             


Val Val  Gln Ser Gly Ile Lys  Val Arg Leu Gln Leu  Tyr Arg Thr 
    1055                 1060                 1065             


Ala Lys  Met Gly Trp Gly Val  Arg Ala Leu Gln Thr  Ile Pro Gln 
    1070                 1075                 1080             


Gly Thr  Phe Ile Cys Glu Tyr  Val Gly Glu Leu Ile  Ser Asp Ala 
    1085                 1090                 1095             


Glu Ala  Asp Val Arg Glu Asp  Asp Ser Tyr Leu Phe  Asp Leu Asp 
    1100                 1105                 1110             


Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp Ala Arg  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Ile  Ser Arg Phe Ile Asn  His Leu Cys Asp Pro  Asn Ile Ile 
    1130                 1135                 1140             


Pro Val  Arg Val Phe Met Leu  His Gln Asp Leu Arg  Phe Pro Arg 
    1145                 1150                 1155             


Ile Ala  Phe Phe Ser Ser Arg  Asp Ile Arg Thr Gly  Glu Glu Leu 
    1160                 1165                 1170             


Gly Phe  Asp Tyr Gly Asp Arg  Phe Trp Asp Ile Lys  Ser Lys Tyr 
    1175                 1180                 1185             


Phe Thr  Cys Gln Cys Gly Ser  Glu Lys Cys Lys His  Ser Ala Glu 
    1190                 1195                 1200             


Ala Ile  Ala Leu Glu Gln Ser  Arg Leu Ala Arg Leu  Asp Pro His 
    1205                 1210                 1215             


Pro Glu  Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
    1220                 1225                 1230             


<210>  198
<211>  1176
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Glu Gly Glu 
1               5                   10                  15      


Ala Pro Ala Glu Met Gly Ala Leu Leu Leu Glu Lys Glu Thr Arg Gly 
            20                  25                  30          


Ala Thr Glu Arg Val His Gly Ser Leu Gly Asp Thr Pro Arg Ser Glu 
        35                  40                  45              


Glu Thr Leu Pro Lys Ala Thr Pro Asp Ser Leu Glu Pro Ala Gly Pro 
    50                  55                  60                  


Ser Ser Pro Ala Ser Val Thr Val Thr Val Gly Asp Glu Gly Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gly Ala Thr Pro Leu Ile Gly Asp Glu Ser Glu Asn Leu 
                85                  90                  95      


Glu Gly Asp Gly Asp Leu Arg Gly Gly Arg Ile Leu Leu Gly His Ala 
            100                 105                 110         


Thr Lys Ser Phe Pro Ser Ser Pro Ser Lys Gly Gly Ser Cys Pro Ser 
        115                 120                 125             


Arg Ala Lys Met Ser Met Thr Gly Ala Gly Lys Ser Pro Pro Ser Val 
    130                 135                 140                 


Gln Ser Leu Ala Met Arg Leu Leu Ser Met Pro Gly Ala Gln Gly Ala 
145                 150                 155                 160 


Ala Ala Ala Gly Ser Glu Pro Pro Pro Ala Thr Thr Ser Pro Glu Gly 
                165                 170                 175     


Gln Pro Lys Val His Arg Ala Arg Lys Thr Met Ser Lys Pro Gly Asn 
            180                 185                 190         


Gly Gln Pro Pro Val Pro Glu Lys Arg Pro Pro Glu Ile Gln His Phe 
        195                 200                 205             


Arg Met Ser Asp Asp Val His Ser Leu Gly Lys Val Thr Ser Asp Leu 
    210                 215                 220                 


Ala Lys Arg Arg Lys Leu Asn Ser Gly Gly Gly Leu Ser Glu Glu Leu 
225                 230                 235                 240 


Gly Ser Ala Arg Arg Ser Gly Glu Val Thr Leu Thr Lys Gly Asp Pro 
                245                 250                 255     


Gly Ser Leu Glu Glu Trp Glu Thr Val Val Gly Asp Asp Phe Ser Leu 
            260                 265                 270         


Tyr Tyr Asp Ser Tyr Ser Val Asp Glu Arg Val Asp Ser Asp Ser Lys 
        275                 280                 285             


Ser Glu Val Glu Ala Leu Thr Glu Gln Leu Ser Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Glu Glu Asp Glu Glu Ser Gly Asn Gln Ser Asp Arg Ser Gly Ser 
                325                 330                 335     


Ser Gly Arg Arg Lys Ala Lys Lys Lys Trp Arg Lys Asp Ser Pro Trp 
            340                 345                 350         


Val Lys Pro Ser Arg Lys Arg Arg Lys Arg Glu Pro Pro Arg Ala Lys 
        355                 360                 365             


Glu Pro Arg Gly Val Ser Asn Asp Thr Ser Ser Leu Glu Thr Glu Arg 
    370                 375                 380                 


Gly Phe Glu Glu Leu Pro Leu Cys Ser Cys Arg Met Glu Ala Pro Lys 
385                 390                 395                 400 


Ile Asp Arg Ile Ser Glu Arg Ala Gly His Lys Cys Met Ala Thr Glu 
                405                 410                 415     


Ser Val Asp Gly Glu Leu Ser Gly Cys Asn Ala Ala Ile Leu Lys Arg 
            420                 425                 430         


Glu Thr Met Arg Pro Ser Ser Arg Val Ala Leu Met Val Leu Cys Glu 
        435                 440                 445             


Thr His Arg Ala Arg Met Val Lys His His Cys Cys Pro Gly Cys Gly 
    450                 455                 460                 


Tyr Phe Cys Thr Ala Gly Thr Phe Leu Glu Cys His Pro Asp Phe Arg 
465                 470                 475                 480 


Val Ala His Arg Phe His Lys Ala Cys Val Ser Gln Leu Asn Gly Met 
                485                 490                 495     


Val Phe Cys Pro His Cys Gly Glu Asp Ala Ser Glu Ala Gln Glu Val 
            500                 505                 510         


Thr Ile Pro Arg Gly Asp Gly Val Thr Pro Pro Ala Gly Thr Ala Ala 
        515                 520                 525             


Pro Ala Pro Pro Pro Leu Ser Gln Asp Val Pro Gly Arg Ala Asp Thr 
    530                 535                 540                 


Ser Gln Pro Ser Ala Arg Met Arg Gly His Gly Glu Pro Arg Arg Pro 
545                 550                 555                 560 


Pro Cys Asp Pro Leu Ala Asp Thr Ile Asp Ser Ser Gly Pro Ser Leu 
                565                 570                 575     


Thr Leu Pro Asn Gly Gly Cys Leu Ser Ala Val Gly Leu Pro Leu Gly 
            580                 585                 590         


Pro Gly Arg Glu Ala Leu Glu Lys Ala Leu Val Ile Gln Glu Ser Glu 
        595                 600                 605             


Arg Arg Lys Lys Leu Arg Phe His Pro Arg Gln Leu Tyr Leu Ser Val 
    610                 615                 620                 


Lys Gln Gly Glu Leu Gln Lys Val Ile Leu Met Leu Leu Asp Asn Leu 
625                 630                 635                 640 


Asp Pro Asn Phe Gln Ser Asp Gln Gln Ser Lys Arg Thr Pro Leu His 
                645                 650                 655     


Ala Ala Ala Gln Lys Gly Ser Val Glu Ile Cys His Val Leu Leu Gln 
            660                 665                 670         


Ala Gly Ala Asn Ile Asn Ala Val Asp Lys Gln Gln Arg Thr Pro Leu 
        675                 680                 685             


Met Glu Ala Val Val Asn Asn His Leu Glu Val Ala Arg Tyr Met Val 
    690                 695                 700                 


Gln Arg Gly Gly Cys Val Tyr Ser Lys Glu Glu Asp Gly Ser Thr Cys 
705                 710                 715                 720 


Leu His His Ala Ala Lys Ile Gly Asn Leu Glu Met Val Ser Leu Leu 
                725                 730                 735     


Leu Ser Thr Gly Gln Val Asp Val Asn Ala Gln Asp Ser Gly Gly Trp 
            740                 745                 750         


Thr Pro Ile Ile Trp Ala Ala Glu His Lys His Ile Glu Val Ile Arg 
        755                 760                 765             


Met Leu Leu Thr Arg Gly Ala Asp Val Thr Leu Thr Asp Asn Glu Glu 
    770                 775                 780                 


Asn Ile Cys Leu His Trp Ala Ser Phe Thr Gly Ser Ala Ala Ile Ala 
785                 790                 795                 800 


Glu Val Leu Leu Asn Ala Arg Cys Asp Leu His Ala Val Asn Tyr His 
                805                 810                 815     


Gly Asp Thr Pro Leu His Ile Ala Ala Arg Glu Ser Tyr His Asp Cys 
            820                 825                 830         


Val Leu Leu Phe Leu Ser Arg Gly Ala Asn Pro Glu Leu Arg Asn Lys 
        835                 840                 845             


Glu Gly Asp Thr Ala Trp Asp Leu Thr Pro Glu Arg Ser Asp Val Trp 
    850                 855                 860                 


Phe Ala Leu Gln Leu Asn Arg Lys Leu Arg Leu Gly Val Gly Asn Arg 
865                 870                 875                 880 


Ala Ile Arg Thr Glu Lys Ile Ile Cys Arg Asp Val Ala Arg Gly Tyr 
                885                 890                 895     


Glu Asn Val Pro Ile Pro Cys Val Asn Gly Val Asp Gly Glu Pro Cys 
            900                 905                 910         


Pro Glu Asp Tyr Lys Tyr Ile Ser Glu Asn Cys Glu Thr Ser Thr Met 
        915                 920                 925             


Asn Ile Asp Arg Asn Ile Thr His Leu Gln His Cys Thr Cys Val Asp 
    930                 935                 940                 


Asp Cys Ser Ser Ser Asn Cys Leu Cys Gly Gln Leu Ser Ile Arg Cys 
945                 950                 955                 960 


Trp Tyr Asp Lys Asp Gly Arg Leu Leu Gln Glu Phe Asn Lys Ile Glu 
                965                 970                 975     


Pro Pro Leu Ile Phe Glu Cys Asn Gln Ala Cys Ser Cys Trp Arg Asn 
            980                 985                 990         


Cys Lys Asn Arg Val Val Gln Ser  Gly Ile Lys Val Arg  Leu Gln Leu 
        995                 1000                 1005             


Tyr Arg  Thr Ala Lys Met Gly  Trp Gly Val Arg Ala  Leu Gln Thr 
    1010                 1015                 1020             


Ile Pro  Gln Gly Thr Phe Ile  Cys Glu Tyr Val Gly  Glu Leu Ile 
    1025                 1030                 1035             


Ser Asp  Ala Glu Ala Asp Val  Arg Glu Asp Asp Ser  Tyr Leu Phe 
    1040                 1045                 1050             


Asp Leu  Asp Asn Lys Asp Gly  Glu Val Tyr Cys Ile  Asp Ala Arg 
    1055                 1060                 1065             


Tyr Tyr  Gly Asn Ile Ser Arg  Phe Ile Asn His Leu  Cys Asp Pro 
    1070                 1075                 1080             


Asn Ile  Ile Pro Val Arg Val  Phe Met Leu His Gln  Asp Leu Arg 
    1085                 1090                 1095             


Phe Pro  Arg Ile Ala Phe Phe  Ser Ser Arg Asp Ile  Arg Thr Gly 
    1100                 1105                 1110             


Glu Glu  Leu Gly Phe Asp Tyr  Gly Asp Arg Phe Trp  Asp Ile Lys 
    1115                 1120                 1125             


Ser Lys  Tyr Phe Thr Cys Gln  Cys Gly Ser Glu Lys  Cys Lys His 
    1130                 1135                 1140             


Ser Ala  Glu Ala Ile Ala Leu  Glu Gln Ser Arg Leu  Ala Arg Leu 
    1145                 1150                 1155             


Asp Pro  His Pro Glu Leu Leu  Pro Glu Leu Gly Ser  Leu Pro Pro 
    1160                 1165                 1170             


Val Asn  Thr 
    1175     


<210>  199
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Ser Asn 
            420                 425                 430         


Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu Pro Leu 
        435                 440                 445             


Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser Glu Arg 
    450                 455                 460                 


Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu Leu Ser 
465                 470                 475                 480 


Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro Ser Ser 
                485                 490                 495     


Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg Met Val 
            500                 505                 510         


Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly Thr 
        515                 520                 525             


Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe His Lys 
    530                 535                 540                 


Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His Cys Gly 
545                 550                 555                 560 


Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly Asp Gly 
                565                 570                 575     


Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro Leu Ser 
            580                 585                 590         


Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala Arg Met 
        595                 600                 605             


Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu Ala Asp 
    610                 615                 620                 


Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly Gly Cys 
625                 630                 635                 640 


Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala Leu Glu 
                645                 650                 655     


Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu Arg Phe 
            660                 665                 670         


His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu Gln Lys 
        675                 680                 685             


Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln Ser Asp 
    690                 695                 700                 


Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser 
705                 710                 715                 720 


Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala 
                725                 730                 735     


Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn 
            740                 745                 750         


His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr 
        755                 760                 765             


Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile 
    770                 775                 780                 


Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp 
785                 790                 795                 800 


Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala 
                805                 810                 815     


Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala 
            820                 825                 830         


Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 
        835                 840                 845             


Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg 
    850                 855                 860                 


Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile 
865                 870                 875                 880 


Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg 
                885                 890                 895     


Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp 
            900                 905                 910         


Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg 
        915                 920                 925             


Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile 
    930                 935                 940                 


Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys 
945                 950                 955                 960 


Val Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile 
                965                 970                 975     


Ser Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr 
            980                 985                 990         


His Leu Gln His Cys Thr Cys Val  Asp Asp Cys Ser Ser  Ser Asn Cys 
        995                 1000                 1005             


Leu Cys  Gly Gln Leu Ser Ile  Arg Cys Trp Tyr Asp  Lys Asp Gly 
    1010                 1015                 1020             


Arg Leu  Leu Gln Glu Phe Asn  Lys Ile Glu Pro Pro  Leu Ile Phe 
    1025                 1030                 1035             


Glu Cys  Asn Gln Ala Cys Ser  Cys Trp Arg Asn Cys  Lys Asn Arg 
    1040                 1045                 1050             


Val Val  Gln Ser Gly Ile Lys  Val Arg Leu Gln Leu  Tyr Arg Thr 
    1055                 1060                 1065             


Ala Lys  Met Gly Trp Gly Val  Arg Ala Leu Gln Thr  Ile Pro Gln 
    1070                 1075                 1080             


Gly Thr  Phe Ile Cys Glu Tyr  Val Gly Glu Leu Ile  Ser Asp Ala 
    1085                 1090                 1095             


Glu Ala  Asp Val Arg Glu Asp  Asp Ser Tyr Leu Phe  Asp Leu Asp 
    1100                 1105                 1110             


Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp Ala Arg  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Ile  Ser Arg Phe Ile Asn  His Leu Cys Asp Pro  Asn Ile Ile 
    1130                 1135                 1140             


Pro Val  Arg Val Phe Met Leu  His Gln Asp Leu Arg  Phe Pro Arg 
    1145                 1150                 1155             


Ile Ala  Phe Phe Ser Ser Arg  Asp Ile Arg Thr Gly  Glu Glu Leu 
    1160                 1165                 1170             


Gly Phe  Asp Tyr Gly Asp Arg  Phe Trp Asp Ile Lys  Ser Lys Tyr 
    1175                 1180                 1185             


Phe Thr  Cys Gln Cys Gly Ser  Glu Lys Cys Lys His  Ser Ala Glu 
    1190                 1195                 1200             


Ala Ile  Ala Leu Glu Gln Ser  Arg Leu Ala Arg Leu  Asp Pro His 
    1205                 1210                 1215             


Pro Glu  Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
    1220                 1225                 1230             


<210>  200
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile Asp 
785                 790                 795                 800 


Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu Asn 
                805                 810                 815     


Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val 
            820                 825                 830         


Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala Ala Lys 
        835                 840                 845             


Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly Gln Met 
    850                 855                 860                 


Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile Trp Ala 
865                 870                 875                 880 


Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser Lys Gly 
                885                 890                 895     


Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu His Trp 
            900                 905                 910         


Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu Ala Ala 
        915                 920                 925             


Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro Leu His 
    930                 935                 940                 


Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe Leu Ser 
945                 950                 955                 960 


Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr Pro Leu 
                965                 970                 975     


Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln Met Ser 
            980                 985                 990         


Lys Ala Leu Gln Asp Ser Ala Pro  Asp Arg Pro Ser Pro  Val Glu Arg 
        995                 1000                 1005             


Ile Val  Ser Arg Asp Ile Ala  Arg Gly Tyr Glu Arg  Ile Pro Ile 
    1010                 1015                 1020             


Pro Cys  Val Asn Ala Val Asp  Ser Glu Pro Cys Pro  Ser Asn Tyr 
    1025                 1030                 1035             


Lys Tyr  Val Ser Gln Asn Cys  Val Thr Ser Pro Met  Asn Ile Asp 
    1040                 1045                 1050             


Arg Asn  Ile Thr His Leu Gln  Tyr Cys Val Cys Ile  Asp Asp Cys 
    1055                 1060                 1065             


Ser Ser  Ser Asn Cys Met Cys  Gly Gln Leu Ser Met  Arg Cys Trp 
    1070                 1075                 1080             


Tyr Asp  Lys Asp Gly Arg Leu  Leu Pro Glu Phe Asn  Met Ala Glu 
    1085                 1090                 1095             


Pro Pro  Leu Ile Phe Glu Cys  Asn His Ala Cys Ser  Cys Trp Arg 
    1100                 1105                 1110             


Asn Cys  Arg Asn Arg Val Val  Gln Asn Gly Leu Arg  Ala Arg Leu 
    1115                 1120                 1125             


Gln Leu  Tyr Arg Thr Arg Asp  Met Gly Trp Gly Val  Arg Ser Leu 
    1130                 1135                 1140             


Gln Asp  Ile Pro Pro Gly Thr  Phe Val Cys Glu Tyr  Val Gly Glu 
    1145                 1150                 1155             


Leu Ile  Ser Asp Ser Glu Ala  Asp Val Arg Glu Glu  Asp Ser Tyr 
    1160                 1165                 1170             


Leu Phe  Asp Leu Asp Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp 
    1175                 1180                 1185             


Ala Arg  Phe Tyr Gly Asn Val  Ser Arg Phe Ile Asn  His His Cys 
    1190                 1195                 1200             


Glu Pro  Asn Leu Val Pro Val  Arg Val Phe Met Ala  His Gln Asp 
    1205                 1210                 1215             


Leu Arg  Phe Pro Arg Ile Ala  Phe Phe Ser Thr Arg  Leu Ile Glu 
    1220                 1225                 1230             


Ala Gly  Glu Gln Leu Gly Phe  Asp Tyr Gly Glu Arg  Phe Trp Asp 
    1235                 1240                 1245             


Ile Lys  Gly Lys Leu Phe Ser  Cys Arg Cys Gly Ser  Pro Lys Cys 
    1250                 1255                 1260             


Arg His  Ser Ser Ala Ala Leu  Ala Gln Arg Gln Ala  Ser Ala Ala 
    1265                 1270                 1275             


Gln Glu  Ala Gln Glu Asp Gly  Leu Pro Asp Thr Ser  Ser Ala Ala 
    1280                 1285                 1290             


Ala Ala  Asp Pro Leu 
    1295             


<210>  201
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Phe Cys Arg Leu Gly Ser 
785                 790                 795                 800 


Pro Arg Ser Arg Gly Cys Leu Trp 
                805             


<210>  202
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  203
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Glu Gln Ile 
            500                 505                 510         


His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly Phe Val Ile Val 
        515                 520                 525             


Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu 
    530                 535                 540                 


Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn 
545                 550                 555                 560 


Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His 
                565                 570                 575     


Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly 
            580                 585                 590         


Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile 
        595                 600                 605             


Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser 
    610                 615                 620                 


Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu 
625                 630                 635                 640 


Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys 
                645                 650                 655     


Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly 
            660                 665                 670         


Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser 
        675                 680                 685             


Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His 
    690                 695                 700                 


Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met 
705                 710                 715                 720 


Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg 
                725                 730                 735     


Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile 
            740                 745                 750         


Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe 
        755                 760                 765             


Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys 
    770                 775                 780                 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg 
785                 790                 795                 800 


Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp 
                805                 810                 815     


Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met 
            820                 825                 830         


Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val 
        835                 840                 845             


Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser 
    850                 855                 860                 


Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys 
865                 870                 875                 880 


Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr 
                885                 890                 895     


Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr 
            900                 905                 910         


Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr 
        915                 920                 925             


Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys 
    930                 935                 940                 


Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala 
945                 950                 955                 960 


Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970         


<210>  204
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  205
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  206
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Asp Tyr Asp Ser Tyr Gln His Tyr Phe Tyr Asp Tyr Asp Cys Gly 
1               5                   10                  15      


Glu Asp Phe Tyr Arg Ser Thr Ala Pro Ser Glu Asp Ile Trp Lys Lys 
            20                  25                  30          


Phe Glu Leu Val Pro Ser Pro Pro Thr Ser Pro Pro Trp Gly Leu Gly 
        35                  40                  45              


Pro Gly Ala Gly Asp Pro Ala Pro Gly Ile Gly Pro Pro Glu Pro Trp 
    50                  55                  60                  


Pro Gly Gly Cys Thr Gly Asp Glu Ala Glu Ser Arg Gly His Ser Lys 
65                  70                  75                  80  


Gly Trp Gly Arg Asn Tyr Ala Ser Ile Ile Arg Arg Asp Cys Met Trp 
                85                  90                  95      


Ser Gly Phe Ser Ala Arg Glu Arg Leu Glu Arg Ala Val Ser Asp Arg 
            100                 105                 110         


Leu Ala Pro Gly Ala Pro Arg Gly Asn Pro Pro Lys Ala Ser Ala Ala 
        115                 120                 125             


Pro Asp Cys Thr Pro Ser Leu Glu Ala Gly Asn Pro Ala Pro Ala Ala 
    130                 135                 140                 


Pro Cys Pro Leu Gly Glu Pro Lys Thr Gln Ala Cys Ser Gly Ser Glu 
145                 150                 155                 160 


Ser Pro Ser Asp Ser Glu Asn Glu Glu Ile Asp Val Val Thr Val Glu 
                165                 170                 175     


Lys Arg Gln Ser Leu Gly Ile Arg Lys Pro Val Thr Ile Thr Val Arg 
            180                 185                 190         


Ala Asp Pro Leu Asp Pro Cys Met Lys His Phe His Ile Ser Ile His 
        195                 200                 205             


Gln Gln Gln His Asn Tyr Ala Ala Arg Phe Pro Pro Glu Ser Cys Ser 
    210                 215                 220                 


Gln Glu Glu Ala Ser Glu Arg Gly Pro Gln Glu Glu Val Leu Glu Arg 
225                 230                 235                 240 


Asp Ala Ala Gly Glu Lys Glu Asp Glu Glu Asp Glu Glu Ile Val Ser 
                245                 250                 255     


Pro Pro Pro Val Glu Ser Glu Ala Ala Gln Ser Cys His Pro Lys Pro 
            260                 265                 270         


Val Ser Ser Asp Thr Glu Asp Val Thr Lys Arg Lys Asn His Asn Phe 
        275                 280                 285             


Leu Glu Arg Lys Arg Arg Asn Asp Leu Arg Ser Arg Phe Leu Ala Leu 
    290                 295                 300                 


Arg Asp Gln Val Pro Thr Leu Ala Ser Cys Ser Lys Ala Pro Lys Val 
305                 310                 315                 320 


Val Ile Leu Ser Lys Ala Leu Glu Tyr Leu Gln Ala Leu Val Gly Ala 
                325                 330                 335     


Glu Lys Arg Met Ala Thr Glu Lys Arg Gln Leu Arg Cys Arg Gln Gln 
            340                 345                 350         


Gln Leu Gln Lys Arg Ile Ala Tyr Leu Thr Gly Tyr 
        355                 360                 


<210>  207
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  208
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Leu Phe Tyr Leu 
            20                  25                  30          


Gly Gln Tyr Ile Met Thr Lys Arg Leu Tyr Asp Glu Lys Gln Gln His 
        35                  40                  45              


Ile Val Tyr Cys Ser Asn Asp Leu Leu Gly Asp Leu Phe Gly Val Pro 
    50                  55                  60                  


Ser Phe Ser Val Lys Glu His Arg Lys Ile Tyr Thr Met Ile Tyr Arg 
65                  70                  75                  80  


Asn Leu Val Val Val Asn Gln Gln Glu Ser Ser Asp Ser Gly Thr Ser 
                85                  90                  95      


Val Ser Glu Asn Arg Cys His Leu Glu Gly Gly Ser Asp Gln Lys Asp 
            100                 105                 110         


Leu Val Gln Glu Leu Gln Glu Glu Lys Pro Ser Ser Ser His Leu Val 
        115                 120                 125             


Ser Arg Pro Ser Thr Ser Ser Arg Arg Arg Ala Ile Ser Glu Thr Glu 
    130                 135                 140                 


Glu Asn Ser Asp Glu Leu Ser Gly Glu Arg Gln Arg Lys Arg His Lys 
145                 150                 155                 160 


Ser Asp Ser Ile Ser Leu Ser Phe Asp Glu Ser Leu Ala Leu Cys Val 
                165                 170                 175     


Ile Arg Glu Ile Cys Cys Glu Arg Ser Ser Ser Ser Glu Ser Thr Gly 
            180                 185                 190         


Thr Pro Ser Asn Pro Asp Leu Asp Ala Gly Val Ser Glu His Ser Gly 
        195                 200                 205             


Asp Trp Leu Asp Gln Asp Ser Val Ser Asp Gln Phe Ser Val Glu Phe 
    210                 215                 220                 


Glu Val Glu Ser Leu Asp Ser Glu Asp Tyr Ser Leu Ser Glu Glu Gly 
225                 230                 235                 240 


Gln Glu Leu Ser Asp Glu Asp Asp Glu Val Tyr Gln Val Thr Val Tyr 
                245                 250                 255     


Gln Ala Gly Glu Ser Asp Thr Asp Ser Phe Glu Glu Asp Pro Glu Ile 
            260                 265                 270         


Ser Leu Ala Asp Tyr Trp Lys Cys Thr Ser Cys Asn Glu Met Asn Pro 
        275                 280                 285             


Pro Leu Pro Ser His Cys Asn Arg Cys Trp Ala Leu Arg Glu Asn Trp 
    290                 295                 300                 


Leu Pro Glu Asp Lys Gly Lys Asp Lys Gly Glu Ile Ser Glu Lys Ala 
305                 310                 315                 320 


Lys Leu Glu Asn Ser Thr Gln Ala Glu Glu Gly Phe Asp Val Pro Asp 
                325                 330                 335     


Cys Lys Lys Thr Ile Val Asn Asp Ser Arg Glu Ser Cys Val Glu Glu 
            340                 345                 350         


Asn Asp Asp Lys Ile Thr Gln Ala Ser Gln Ser Gln Glu Ser Glu Asp 
        355                 360                 365             


Tyr Phe Gln Pro Ser Thr Ser Ser Ser Ile Ile Tyr Ser Cys Gln Glu 
    370                 375                 380                 


Asp Val Lys Glu Phe Glu Arg Glu Glu Thr Gln Asp Lys Glu Glu Ser 
385                 390                 395                 400 


Val Glu Ser Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys 
                405                 410                 415     


Gln Gly Arg Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His 
            420                 425                 430         


Leu Met Ala Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys 
        435                 440                 445             


Pro Cys Pro Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr 
    450                 455                 460                 


Phe Pro 
465     


<210>  209
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Glu Leu Pro Thr Lys Pro Gly Thr Phe Asp Leu Gly Leu Ala Thr 
1               5                   10                  15      


Trp Ser Pro Ser Phe Gln Gly Glu Thr His Arg Ala Gln Ala Arg Arg 
            20                  25                  30          


Arg Asp Val Gly Arg Gln Leu Pro Glu Tyr Lys Ala Val Val Val Gly 
        35                  40                  45              


Ala Ser Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Asn His Gln 
    50                  55                  60                  


Cys Phe Val Glu Asp His Asp Pro Thr Ile Gln Asp Ser Tyr Trp Lys 
65                  70                  75                  80  


Glu Leu Thr Leu Asp Ser Gly Asp Cys Ile Leu Asn Val Leu Asp Thr 
                85                  90                  95      


Ala Gly Gln Ala Ile His Arg Ala Leu Arg Asp Gln Cys Leu Ala Val 
            100                 105                 110         


Cys Asp Gly Val Leu Gly Val Phe Ala Leu Asp Asp Pro Ser Ser Leu 
        115                 120                 125             


Ile Gln Leu Gln Gln Ile Trp Ala Thr Trp Gly Pro His Pro Ala Gln 
    130                 135                 140                 


Pro Leu Val Leu Val Gly Asn Lys Cys Asp Leu Val Thr Thr Ala Gly 
145                 150                 155                 160 


Asp Ala His Ala Ala Ala Ala Ala Leu Ala His Ser Trp Gly Ala His 
                165                 170                 175     


Phe Val Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Ser Leu Leu Val His Glu Ile Gln Arg Val Gln Glu Ala Met Ala Lys 
        195                 200                 205             


Glu Pro Met Ala Arg Ser Cys Arg Glu Lys Thr Arg His Gln Lys Ala 
    210                 215                 220                 


Thr Cys His Cys Gly Cys Ser Val Ala 
225                 230             


<210>  210
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Arg Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


His Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Ser Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  211
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
1               5                   10                  15      


Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
            20                  25                  30          


Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
        35                  40                  45              


Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
    50                  55                  60                  


Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
65                  70                  75                  80  


Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                85                  90                  95      


Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
            100                 105                 110         


Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
145                 150                 155                 160 


Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                165                 170                 175     


Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
            180                 185                 190         


His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
    210                 215                 220                 


Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
225                 230                 235                 240 


Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                245                 250                 255     


Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
            260                 265                 270         


Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
        275                 280                 285             


Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
    290                 295                 300                 


Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
305                 310                 315         


<210>  212
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Thr Ala Met Glu Glu Ser Gln Ser Asp Ile Ser Leu Glu Leu Pro 
1               5                   10                  15      


Leu Ser Gln Glu Thr Phe Ser Gly Leu Trp Lys Leu Leu Pro Pro Glu 
            20                  25                  30          


Asp Ile Leu Pro Ser Pro His Cys Met Asp Asp Leu Leu Leu Pro Gln 
        35                  40                  45              


Asp Val Glu Glu Phe Phe Glu Gly Pro Ser Glu Ala Leu Arg Val Ser 
    50                  55                  60                  


Gly Ala Pro Ala Ala Gln Asp Pro Val Thr Glu Thr Pro Gly Pro Val 
65                  70                  75                  80  


Ala Pro Ala Pro Ala Thr Pro Trp Pro Leu Ser Ser Phe Val Pro Ser 
                85                  90                  95      


Gln Lys Thr Tyr Gln Gly Asn Tyr Gly Phe His Leu Gly Phe Leu Gln 
            100                 105                 110         


Ser Gly Thr Ala Lys Ser Val Met Cys Thr Tyr Ser Pro Pro Leu Asn 
        115                 120                 125             


Lys Leu Phe Phe Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val 
    130                 135                 140                 


Ser Ala Thr Pro Pro Ala Gly Ser Arg Val Arg Ala Met Ala Ile Tyr 
145                 150                 155                 160 


Lys Lys Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His 
                165                 170                 175     


Glu Arg Cys Ser Asp Gly Asp Gly Leu Ala Pro Pro Gln His Leu Ile 
            180                 185                 190         


Arg Val Glu Gly Asn Leu Tyr Pro Glu Tyr Leu Glu Asp Arg Gln Thr 
        195                 200                 205             


Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Ala Gly Ser 
    210                 215                 220                 


Glu Tyr Thr Thr Ile His Tyr Lys Tyr Met Cys Asn Ser Ser Cys Met 
225                 230                 235                 240 


Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp 
                245                 250                 255     


Ser Ser Gly Asn Leu Leu Gly Arg Asp Ser Phe Glu Val Arg Val Cys 
            260                 265                 270         


Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Phe Arg Lys 
        275                 280                 285             


Lys Glu Val Leu Cys Pro Glu Leu Pro Pro Gly Ser Ala Lys Arg Ala 
    290                 295                 300                 


Leu Pro Thr Cys Thr Ser Ala Ser Pro Pro Gln Lys Lys Lys Pro Leu 
305                 310                 315                 320 


Asp Gly Glu Tyr Phe Thr Leu Lys Ile Arg Gly Arg Lys Arg Phe Glu 
                325                 330                 335     


Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala His Ala 
            340                 345                 350         


Thr Glu Glu Ser Gly Asp Ser Arg Ala His Ser Ser Leu Gln Pro Arg 
        355                 360                 365             


Ala Phe Gln Ala Leu Ile Lys Glu Glu Ser Pro Asn Cys 
    370                 375                 380     


<210>  213
<211>  12359
<212>  DNA
<213>  Homo sapiens

<400>  213
tgaaacggag tctctcgctg tcacccaggc tggagtgcag tagcacgatc ttggctcact       60

gcaacatctg cctcccgggt tcaagcaatt ctcctgcctc agcctcctga gtagctggga      120

ctacaggtgc gctccaccac ccccagctaa tttttgtatt tttagtggag acggggtttc      180

accatgttgg tcaggctggt cttgaactcc tgacctcatg atcctctcac ctcggcctca      240

caaagtgcta ggattacagg cgcatggcca agaatgaatg attatttgtg ccttcctatg      300

tgaaaaaaaa atgtttcctc tagctacaca ctattctgtt ctgtgaggcc gccccatcag      360

actgttgacc tagagtccca accccggccc tccaggagac ctgcctgttc ttagaagccc      420

aacccactca gcagcagctc caaataacag ggggagccaa caaaaaagag tgctgctaga      480

gcaacaagca aggggcaatt agtcagaagg caacttccat ggtcttccaa aaaaaattga      540

ggtgaaagac caaagatgtc cctaaaatgt cttcctaaaa gataaacttc atcaactacc      600

tctgactggt cagtattaag aaccactttc aggccaggtg tcatggttca cgcctgtaac      660

tccatctact ccagaggctg aggcaggaca attgcttcag gccggaggat tgcttgaggc      720

caggagctgg agaccaagcc tgagcaacac agtgagacct catctctacc aaaaatgtac      780

ctctattaaa aaacaaaaaa gaagaagaag aagaagaaga aggagaggag gctgggtatg      840

gtggctaatg cctttgtaat cccagaactt tggaaggctg aggcaggaga atcacttagg      900

ctgaggcagg agaatcacca gagtctagga gtttgagacc agcctgggca acatagtgag      960

acccccatct ctacaaaaaa aaaaattcaa aaattagcca agcgtggggt ttgtgcctgt     1020

agacccaact actcaggagg ctcaggtagg aggatcacct gagtccaggg aggtcgaggc     1080

tgcagtgagt catgattatt ccactgcctt ccagcctaga ctacagggtg agaccctgtc     1140

ttaaaaaaaa aattaaagaa gaaaaaactc tcttttcttt tctttctttc ttcttcttct     1200

tttctttttt tttttttctt tttttttttt tagagatggc acgtcaccac attgcccagg     1260

ctgttgtcga actcctggcc tcaaacgatg ctcccacttg agcctcccaa agtgctggga     1320

ctacaagcat aagccaccac acacggcctt ttcctttctt tttctatttc tcaatggatt     1380

tttccaatgg acacgtatca ctttggtagt tatacatgat actagttgta atctcagcca     1440

tttttcaacc cagcaaatgt ctattctagg tcaaatatgt ctcaaaaatt actaaaagaa     1500

aatcagttat gtcctttaac ctggctgagg tctggctttg ttttctctca tgtaaaaatg     1560

gagatggcac aaaacaactc caagctgtta cttgaaagta acacctcagg tgatgtcacc     1620

agcctgaggg agagtgaggt taagttctga acccacaggc attatatctg cctggggttc     1680

acatgcccta cactggactg gcataatttg agagtcagat ccgaagatgt ggtatatccg     1740

ccatctttag caactttcaa aaactaccct atgaggtcaa gctggaccta cttttggttt     1800

tgccattgtt gtttgtttgt tgttgagggt tttctttgag gggcggggag tgcatgcccc     1860

tgtggagagc actcatttag cttcaattag agtaatgcca aaagtgccag attcctggga     1920

aatcagccta caaggctcct gcgggaagga acctccactg ccagaagtcc ttagggcatc     1980

taagtgatca gacaccgtca gggattcttt gccccgtaaa aacctacttg accagggaca     2040

cgtgccaggt aaatttcctt cacatttact tcaaccttat tgcatactca ttttagtatt     2100

aaaaccttta ataaaatgct cctattcctt cacacttttt ttctatgaga tctcaaatac     2160

cccttcttgc tattaaaaaa aatcacttat tattcaccag cccaatattt taaaagtaaa     2220

aataataagc caaggccagg agcgatgact cgcacttgta ttcccagcag tttcagaggc     2280

aaaggccgaa ggatcgcttt aaccgaggag tttgagacca gcctgggcaa catgaccaga     2340

ctgcctctct acaaaaagtt taaaaaatta accgggtgtg gtggtgcact gcactcccag     2400

ctactgggct ggggtatcag gctgaggtag gaggtttgct ttgagcccgg ggggatcgag     2460

gctgcagtga gctttgattg tgccactgca ctccagcctg ggtgacagaa ggagaccctg     2520

tctcaaaaat aataagaata ataattaata ataataggcc aaaccaaata cccatcacct     2580

tctgctgtgc ctcccctttc cccaataaat ccagtgtctt gctttcaaat tttgtggtta     2640

aaaaagatga tgagtttcta agacgtgggg gctaaagctt gtttggccgt tttagggttt     2700

gttggaattt ttttttcgtc tatgtacttg tgaattattt cacgtttgcc attaccggtt     2760

ctccataggg tgatgttcat tagcagtggt gataggttaa ttttcaccat ctcttatgcg     2820

gttgaatagt cacctctgaa ccactttttc ctccagtaac tcctctttct tcggaccttc     2880

tgcagccaac ctgaaagaat aacaaggagg tggctggaaa cttgttttaa ggaaccgcct     2940

gtccttcccc cgctggaaac cttgcacctc ggacgctcct gctcctgccc ccacctgacc     3000

cccgccctcg ttgacatcca ggcgcgatga tctctgctgc cagtagaggg cacacttact     3060

ttactttcgc aaacctgaac gcgggtgctg cccagagagg gggcggaggg aaagacgctt     3120

tgcagcaaaa tccagcatag cgattggttg ctccccgcgt ttgcggcaaa ggcctggagg     3180

caggagtaat ttgcaatcct taaagctgaa ttgtgcagtg catcggattt ggaagctact     3240

atattcactt aacacttgaa cgctgagctg caaactcaac gggtaataac ccatcttgaa     3300

cagcgtacat gctatacacg cacccctttc ccccgaattg ttttctcttt tggaggtggt     3360

ggagggagag aaaagtttac ttaaaatgcc tttgggtgag ggaccaagga tgagaagaat     3420

gttttttgtt tttcatgccg tggaataaca caaaataaaa aatcccgagg gaatatacat     3480

tatatattaa atatagatca tttcagggag caaacaaatc atgtgtgggg ctgggcaact     3540

agctaagtcg aagcgtaaat aaaatgtgaa tacacgtttg cgggttacat acagtgcact     3600

ttcactagta ttcagaaaaa attgtgagtc agtgaactag gaaattaatg cctggaaggc     3660

agccaaattt taattagctc aagactcccc cccccccaaa aaaaggcacg gaagtaatac     3720

tcctctcctc ttctttgatc agaatcgatg cattttttgt gcatgaccgc atttccaata     3780

ataaaagggg aaagaggacc tggaaaggaa ttaaacgtcc ggtttgtccg gggaggaaag     3840

agttaacggt ttttttcaca agggtctctg ctgactcccc cggctcggtc cacaagctct     3900

ccacttgccc cttttaggaa gtccggtccc gcggttcggg taccccctgc ccctcccata     3960

ttctcccgtc tagcaccttt gatttctccc aaacccggca gcccgagact gttgcaaacc     4020

ggcgccacag ggcgcaaagg ggatttgtct cttctgaaac ctggctgaga aattgggaac     4080

tccgtgtggg aggcgtgggg gtgggacggt ggggtacaga ctggcagaga gcaggcaacc     4140

tccctctcgc cctagcccag ctctggaaca ggcagacaca tctcagggct aaacagacgc     4200

ctcccgcacg gggccccacg gaagcctgag caggcggggc aggaggggcg gtatctgctg     4260

ctttggcagc aaattggggg actcagtctg ggtggaaggt atccaatcca gatagctgtg     4320

catacataat gcataataca tgactccccc caacaaatgc aatgggagtt tattcataac     4380

gcgctctcca agtatacgtg gcaatgcgtt gctgggttat tttaatcatt ctaggcatcg     4440

ttttcctcct tatgcctcta tcattcctcc ctatctacac taacatccca cgctctgaac     4500

gcgcgcccat taataccctt ctttcctcca ctctccctgg gactcttgat caaagcgcgg     4560

ccctttcccc agccttagcg aggcgccctg cagcctggta cgcgcgtggc gtggcggtgg     4620

gcgcgcagtg cgttctcggt gtggagggca gctgttccgc ctgcgatgat ttatactcac     4680

aggacaagga tgcggtttgt caaacagtac tgctacggag gagcagcaga gaaagggaga     4740

gggtttgaga gggagcaaaa gaaaatggta ggcgcgcgta gttaattcat gcggctctct     4800

tactctgttt acatcctaga gctagagtgc tcggctgccc ggctgagtct cctccccacc     4860

ttccccaccc tccccaccct ccccataagc gcccctcccg ggttcccaaa gcagagggcg     4920

tgggggaaaa gaaaaaagat cctctctcgc taatctccgc ccaccggccc tttataatgc     4980

gagggtctgg acggctgagg acccccgagc tgtgctgctc gcggccgcca ccgccgggcc     5040

ccggccgtcc ctggctcccc tcctgcctcg agaagggcag ggcttctcag aggcttggcg     5100

ggaaaaagaa cggagggagg gatcgcgctg agtataaaag ccggttttcg gggctttatc     5160

taactcgctg tagtaattcc agcgagaggc agagggagcg agcgggcggc cggctagggt     5220

ggaagagccg ggcgagcaga gctgcgctgc gggcgtcctg ggaagggaga tccggagcga     5280

atagggggct tcgcctctgg cccagccctc ccgctgatcc cccagccagc ggtccgcaac     5340

ccttgccgca tccacgaaac tttgcccata gcagcgggcg ggcactttgc actggaactt     5400

acaacacccg agcaaggacg cgactctccc gacgcgggga ggctattctg cccatttggg     5460

gacacttccc cgccgctgcc aggacccgct tctctgaaag gctctccttg cagctgctta     5520

gacgctggat ttttttcggg tagtggaaaa ccaggtaagc accgaagtcc acttgccttt     5580

taatttattt ttttatcact ttaatgctga gatgagtcga atgcctaaat agggtgtctt     5640

ttctcccatt cctgcgctat tgacactttt ctcagagtag ttatggtaac tggggctggg     5700

gtggggggta atccagaact ggatcggggt aaagtgactt gtcaagatgg gagaggagaa     5760

ggcagaggga aaacgggaat ggtttttaag actacccttt cgagatttct gccttatgaa     5820

tatattcacg ctgactcccg gccggtcgga cattcctgct ttattgtgtt aattgctctc     5880

tgggttttgg ggggctgggg gttgctttgc ggtgggcaga aagccccttg catcctgagc     5940

tccttggagt agggaccgca tatcgcctgt gtgagccaga tcgctccgca gccgctgact     6000

tgtccccgtc tccgggaggg catttaaatt tcggctcacc gcatttctga cagccggaga     6060

cggacactgc ggcgcgtccc gcccgcctgt ccccgcggcg attccaaccc gccctgatcc     6120

ttttaagaag ttggcatttg gctttttaaa aagcaataat acaatttaaa acctgggtct     6180

ctagaggtgt taggacgtgg tgttgggtag gcgcaggcag gggaaaaggg aggcgaggat     6240

gtgtccgatt ctcctggaat cgttgacttg gaaaaaccag ggcgaatctc cgcacccagc     6300

cctgactccc ctgccgcggc cgccctcggg tgtcctcgcg cccgagatgc ggaggaactg     6360

cgaggagcgg ggctctgggc ggttccagaa cagctgctac ccttggtggg gtggctccgg     6420

gggaggtatc gcagcggggt ctctggcgca gttgcatctc cgtattgagt gcgaagggag     6480

gtgcccctat tattatttga cacccccctt gtatttatgg aggggtgtta aagcccgcgg     6540

ctgagctcgc cactccagcc ggcgagagaa agaagaaaag ctggcaaaag gagtgttgga     6600

cgggggcggt actgggggtg gggacggggg cggtggagag ggaaggttgg gaggggctgc     6660

ggtgccggcg ggggtaggag agcggctagg gcgcgagtgg gaacagccgc agcggagggg     6720

ccccggcgcg gagcggggtt cacgcagccg ctagcgccca ggcgcctctc gccttctcct     6780

tcaggtggcg caaaactttg tgccttggat tttggcaaat tgttttcctc accgccacct     6840

cccgcggctt cttaagggcg ccagggccga tttcgattcc tctgccgctg cggggccgac     6900

tcccgggctt tgcgctccgg gctcccgggg gagcgggggc tcggcgggca ccaagccgct     6960

ggttcactaa gtgcgtctcc gagatagcag gggactgtcc aaagggggtg aaagggtgct     7020

ccctttattc ccccaccaag accacccagc cgctttaggg gatagctctg caaggggaga     7080

ggttcgggac tgtggcgcgc actgcgcgct gcgccaggtt tccgcaccaa gaccccttta     7140

actcaagact gcctcccgct ttgtgtgccc cgctccagca gcctcccgcg acgatgcccc     7200

tcaacgttag cttcaccaac aggaactatg acctcgacta cgactcggtg cagccgtatt     7260

tctactgcga cgaggaggag aacttctacc agcagcagca gcagagcgag ctgcagcccc     7320

cggcgcccag cgaggatatc tggaagaaat tcgagctgct gcccaccccg cccctgtccc     7380

ctagccgccg ctccgggctc tgctcgccct cctacgttgc ggtcacaccc ttctcccttc     7440

ggggagacaa cgacggcggt ggcgggagct tctccacggc cgaccagctg gagatggtga     7500

ccgagctgct gggaggagac atggtgaacc agagtttcat ctgcgacccg gacgacgaga     7560

ccttcatcaa aaacatcatc atccaggact gtatgtggag cggcttctcg gccgccgcca     7620

agctcgtctc agagaagctg gcctcctacc aggctgcgcg caaagacagc ggcagcccga     7680

accccgcccg cggccacagc gtctgctcca cctccagctt gtacctgcag gatctgagcg     7740

ccgccgcctc agagtgcatc gacccctcgg tggtcttccc ctaccctctc aacgacagca     7800

gctcgcccaa gtcctgcgcc tcgcaagact ccagcgcctt ctctccgtcc tcggattctc     7860

tgctctcctc gacggagtcc tccccgcagg gcagccccga gcccctggtg ctccatgagg     7920

agacaccgcc caccaccagc agcgactctg gtaagcgaag cccgcccagg cctgtcaaaa     7980

gtgggcggct ggataccttt cccattttca ttggcagctt atttaacggg ccactcttat     8040

taggaaggag agatagcaga tctggagaga tttgggagct catcacctct gaaaccttgg     8100

gctttagcgt ttcctcccat cccttcccct tagactgccc atgtttgcag cccccctccc     8160

cgtttgtctc ccacccctca ggaatttcat ttaggttttt aaaccttctg gcttatctta     8220

caactcaatc cacttcttct tacctcccgt taacatttta attgccctgg ggcggggtgg     8280

cagggagtgt atgaatgagg ataagagagg attgatctct gagagtgaat gaattgcttc     8340

cctcttaact tccgagaagt ggtgggattt aatgaactat ctacaaaaat gaggggctgt     8400

gtttagaggc taggcagggc ctgcctgagt gcgggagcca gtgaactgcc tcaagagtgg     8460

gtgggctgag gagctgggat cttctcagcc tattttgaac actgaaaagc aaatccttgc     8520

caaagttgga cttttttttt tcttttattc cttcccccgc cctcttggac ttttggcaaa     8580

actgcaattt tttttttttt atttttcatt tccagtaaaa tagggagttg ctaaagtcat     8640

accaagcaat ttgcagctat catttgcaac acctgaagtg ttcttggtaa agtccctcaa     8700

aaataggagg tgcttgggaa tgtgctttgc tttgggtgtg tccaaagcct cattaagtct     8760

taggtaagaa ttggcatcaa tgtcctatcc tgggaagttg cacttttctt gtccatgcca     8820

taacccagct gtctttccct ttatgagact cttaccttca tggtgagagg agtaagggtg     8880

gctggctaga ttggttcttt tttttttttt ttcctttttt aagacggagt ctcactctgt     8940

cactaggctg gagtgcagtg gcgcaatcaa cctccaaccc cctggttcaa gagattctcc     9000

tgcctcagcc tcccaagtag ctgggactac aggtgcacac caccatgcca ggctaatttt     9060

tgtaatttta gtagagatgg ggtttcatcg tgttggccag gatggtctct cctgacctca     9120

cgatccgccc acctcggcct cccaaagtgc tgggattaca ggtgtgagcc agggcaccag     9180

gcttagatgt ggctctttgg ggagataatt ttgtccagag acctttctaa cgtattcatg     9240

ccttgtattt gtacagcatt aatctggtaa ttgattattt taatgtaacc ttgctaaagg     9300

agtgatttct atttcctttc ttaaagagga ggaacaagaa gatgaggaag aaatcgatgt     9360

tgtttctgtg gaaaagaggc aggctcctgg caaaaggtca gagtctggat caccttctgc     9420

tggaggccac agcaaacctc ctcacagccc actggtcctc aagaggtgcc acgtctccac     9480

acatcagcac aactacgcag cgcctccctc cactcggaag gactatcctg ctgccaagag     9540

ggtcaagttg gacagtgtca gagtcctgag acagatcagc aacaaccgaa aatgcaccag     9600

ccccaggtcc tcggacaccg aggagaatgt caagaggcga acacacaacg tcttggagcg     9660

ccagaggagg aacgagctaa aacggagctt ttttgccctg cgtgaccaga tcccggagtt     9720

ggaaaacaat gaaaaggccc ccaaggtagt tatccttaaa aaagccacag catacatcct     9780

gtccgtccaa gcagaggagc aaaagctcat ttctgaagag gacttgttgc ggaaacgacg     9840

agaacagttg aaacacaaac ttgaacagct acggaactct tgtgcgtaag gaaaagtaag     9900

gaaaacgatt ccttctaaca gaaatgtcct gagcaatcac ctatgaactt gtttcaaatg     9960

catgatcaaa tgcaacctca caaccttggc tgagtcttga gactgaaaga tttagccata    10020

atgtaaactg cctcaaattg gactttgggc ataaaagaac ttttttatgc ttaccatctt    10080

ttttttttct ttaacagatt tgtatttaag aattgttttt aaaaaatttt aagatttaca    10140

caatgtttct ctgtaaatat tgccattaaa tgtaaataac tttaataaaa cgtttatagc    10200

agttacacag aatttcaatc ctagtatata gtacctagta ttataggtac tataaaccct    10260

aatttttttt atttaagtac attttgcttt ttaaagttga tttttttcta ttgtttttag    10320

aaaaaataaa ataactggca aatatatcat tgagccaaat cttaagttgt gaatgttttg    10380

tttcgtttct tccccctccc aaccaccacc atccctgttt gttttcatca attgcccctt    10440

cagagggtgg tcttaagaaa ggcaagagtt ttcctctgtt gaaatgggtc tgggggcctt    10500

aaggtcttta agttcttgga ggttctaaga tgcttcctgg agactatgat aacagccaga    10560

gttgacagtt agaaggaatg gcagaaggca ggtgagaagg tgagaggtag gcaaaggaga    10620

tacaagaggt caaaggtagc agttaagtac acaaagaggc ataaggactg gggagttggg    10680

aggaaggtga ggaagaaact cctgttactt tagttaacca gtgccagtcc cctgctcact    10740

ccaaacccag gaattctgcc cagttgatgg ggacacggtg ggaaccagct tctgctgcct    10800

tcacaaccag gcgccagtcc tgtccatggg ttatctcgca aaccccagag gatctctggg    10860

aggaatgcta ctattaaccc tatttcacaa acaaggaaat agaagagctc aaagaggtta    10920

tgtaacttat ctgtagccac gcagataata caaagcagca atctggaccc attctgttca    10980

aaacacttaa cccttcgcta tcatgccttg gttcatctgg gtctaatgtg ctgagatcaa    11040

gaaggtttag gacctaatgg acagactcaa gtcataacaa tgctaagctc tatttgtgtc    11100

ccaagcactc ctaagcattt tatccctaac tctacatcaa ccccatgaag gagatactgt    11160

tgatttcccc atattagaag tagagaggga agctgaggca cacaaagact catccacatg    11220

cccaagattc actgataggg aaaagtggaa gcgagatttg aacccaggct gtttactcct    11280

aacctgtcca agccacctct cagacgacgg taggaatcag ctggctgctt gtgagtacag    11340

gagttacagt ccagtgggtt atgtttttta agtctcaaca tctaagcctg gtcaggcatc    11400

agttcccctt tttttgtgat ttattttgtt tttattttgt tgttcattgt ttaatttttc    11460

cttttacaat gagaaggtca ccatcttgac tcctacctta gccatttgtt gaatcagact    11520

catgacggct cctgggaaga agccagttca gatcataaaa taaaacatat ttattctttg    11580

tcatgggagt cattatttta gaaactacaa actctccttg cttccatcct tttttacata    11640

ctcatgacac atgctcatcc tgagtccttg aaaaggtatt tttgaacatg tgtattaatt    11700

ataagcctct gaaaacctat ggcccaaacc agaaatgatg ttgattatat aggtaaatga    11760

aggatgctat tgctgttcta attacctcat tgtctcagtc tcaaagtagg tcttcagctc    11820

cctgtacttt gggattttaa tctaccacca cccataaatc aataaataat tactttcttt    11880

gactctgact cctagaataa tctattcaaa accttaatgt ctttttcttg atccttcttt    11940

tgagtcctaa gtaccgccat tacagcttca aattggcacg tcatataggc gaatttcaaa    12000

gggagatgca atccacagaa gtatagtagt tcaaagggtt acaaaagcaa ggcgctctta    12060

aacagctcag tctttgcccc tttgtggcct agggctggag tgcagctctg gggtgactca    12120

cttgggaatc gggaaggtgt tagtctgaat cactaagtcc aggcaagccc tcagaatagg    12180

agagagtgtt cctagcaagg aaaacaactc tccattccaa ataatcagga aagaacttta    12240

gggatgtgga gcttggctat gggaatagaa aggaaccatt ccaagtgcct attaggccgc    12300

tcttaccttt actgagccag agaatggctc tgaaaacagg acagatgcca acttccttc     12359


<210>  214
<211>  13447
<212>  DNA
<213>  Homo sapiens

<400>  214
acatttcccg tctgtaacta tagacctaac acattatttt tagtgggtgt atgtaattcc       60

actgcatgga tgtattacat accattctcc tgtttaattt gttttagtta tggatattta      120

gattgcttat agtatttttg ttattgagaa tgatgcagcc acacacattc ttgtttatat      180

gcttttatgt gtttgtctta ttatttctcg taggatggat catgaagagt ggaattgctt      240

ttcctcttgg ggcaggcaca ccaacagtgt atgtgaggcc cctgctccca ctccccaggc      300

tggccagtac tttgggccaa tctgctagac ccaaaaatgt taatctcact gagatttaat      360

ttgcattccc ctgactaccg gtgaagttga gcatcttttc atatgtttat tgacaatttg      420

catttcttat tcagtaaatt acctgctcgt atcctagagt catatttctg tctgcccgtt      480

tttttctatt caatttgtgg gagctctttg tatacctggg atctaatctt tgactcatat      540

atatggcaag tattttctat tactgttgtc aactttttat catagtaaaa ttcttacatc      600

cagcaccccc acccctcccc tgcccttttt tttttttttt ttgcatttgg gttaggcaga      660

gagctagctt tactgttttc caaatgaagt caatcgatcc caaggatttt taaattattt      720

aatcagtaaa aatgtacaca ttttgaggga ggtgtgaaga tcctaggaga aactgtgctc      780

ttgtccctga agacagactc agtagatctt tttttttttc ttttgagaca aggtctcact      840

ctgtcatcca ggctggagtg cagtggtgtg atgatggcac actgcagcct tgatctccct      900

gggctcaggt gatcttcctg cctcagcctc ccaagtagct gggaccacag gcacgcaccc      960

accacgccca gctaattttt atattttttg tagagacagg gtttcaccat gttgcccagg     1020

ccggtctcaa aatcctgggc tcaagccatc tgccctcctc agactcttga agtgccagga     1080

ttacaggcgt gagccaccat gcctggccaa cccagcagat ctttaattca caatctggaa     1140

aaaccatcta gaggctgttg ctctcctagc cagtcatgat ttgggccctt ctcaacatgt     1200

gtatgtgtgt gttgtttctt tgtgtgtgtg tgtcttagta aagaggagat ttgtaaacta     1260

aaatattctc ctctctcaaa aatcacctta attataaacc aaatgctgtg tataactcta     1320

tcctagcagt tggtgattag attgaggcat ccatttcaga tgtgggtctc cttccctggt     1380

ccacagtgag ctccttgcgg ctgtacctta acttacctct gttccaaacc cacccagggg     1440

ctcagacaca gtaatagatg ggtacttgtc tcagttcatt ttgtgttgct ataacctaat     1500

agcacagact gggtaattta taaagaaaag aaatgtattt ctcatgtttc tggaggctga     1560

gaagtccaat atcaaggtgc cagcaattgc tgagggcctt catggcgtac catcccctgg     1620

caggaaaaag gaagagaggg caagagatca aactcctagc ctcaagccct tttataatta     1680

gcattaatcc attcacaaga gtggagccct catgacctaa acacctcaca ttaggtcctg     1740

agacaggaat aatataaggt ggctgcagaa taatagaaga ttttgggcag caatttcaca     1800

tgactagcaa aaggaaactg ttgaaatggc tgcagaggcc atgggctaag accgtgaaaa     1860

acagagtgta gaccaagctg gctaagaccc actgaaccca gcatggcact ggatttgacc     1920

taggtttctc ctaggacctc attatacgct cattaacata ctaaatcaca caccccacta     1980

gcatcatgac acttccgaga acacccatat ttggtttaaa aataggtggt gtcacagttc     2040

tgagaaatct ccttcttttt ctaggaatga tcatgaatat tctgcctctt ggttaaagaa     2100

acccgtaaag gtagcaaccc caaaccccct ttcgtgtgag tctctcgagt acacccatat     2160

tcccttttct tgagtgtgta cttttccctt tgcaataaat cgtactttca ctattttcca     2220

actggtcttt gaattcattc tcttgatggt gtcaagagcc tggacactgg ctggggtcta     2280

ggtcccactg gcatttgggg acctcccctc caacactgtt gcactggggg ttaaacttcc     2340

aacgtgtttt tttttggagg acacattcaa accatggcag tactgaacaa aaccttggct     2400

ttgaaaccat atgaagattt gttttgtgtg tgttcacata gttgaagtat ttcaacattt     2460

ttaagaggga ttttcaggct tctctataag cagactaaga atcagcatta gcatgttttc     2520

tccatgtaca aagtctttta tctttctact tacaaatgaa ggtaaccaat aaatatttgt     2580

tgaattttat cattctgtta accttcagat tcagacttgt cagtaattac tggcttgcat     2640

taaaagcagg agattagaga ttgaggtcca ggaagtataa atgatttgct caaaggcatg     2700

tagagtaacc aggtctcctg tccctctgtc ccccttttct gctacacctt gtccctcgac     2760

aaagggtgaa tgacctagtg atggtcattc atctgaggag aaaggacaaa ggtaggactt     2820

tgaatcggag caactgaacc catcctggcc tattttcaca gtcttgccac agaagatctg     2880

gccaccttag aaggactcat tcagtgatct tggtcttgaa taataccatg agtacttact     2940

atatacaggt acactgctgt gccgtaagga ttccctctgg agcaaaactg acccaggtca     3000

caggttagtg agggagactg agcctgtctt ccacagtgtc acggaagtga gcactaaaca     3060

aatactccca ggcatggatc attacaaatg gaggtgagtg ctggacagga aaggacagga     3120

tgctaggcga gaattcagca ggagggcttg gtggcgatta gggggctagg gaaaagcaga     3180

agtggggctg taaaaggctt ttgcaaagat gaaggctttt acatttgtga gggaaataac     3240

aataataaag gtgcttggaa gggctgctca tccgcattca tgggcctctt cctagaactc     3300

tgggaatctt tctccctaga gctctgtagg cgtccagggt cagggctgga aaggccttca     3360

caaatgctaa tctgtgagca ttttatgggt tgccccctga ccctcagcat cctcctcctt     3420

aactagatcc aatggtgagg tgaagaggtg ggggcgatgg agaatggcat ttccagtttg     3480

gagaaaaaag tagggagagg cggggaagcc ttcccacccc aatcccaggg ccaggttccc     3540

ctctctccaa acaagcctaa ggaatgtttt tcaaggcaaa atcccacctc actgtgtatt     3600

tggttgtgaa gggggctgtc caggagatca gggttgtttt tggagagttt ggagggcagg     3660

ggcaataatg tctgaccccc tgcaaacaaa tacacctgta agaaaagcta gaccagagtg     3720

aagtaaagcc aggatttgat ggtggcggga agggaagggg ccaatgctgc tgctggacag     3780

aggggtgtta ttttccccag aagaatagca tgtcgtggtc atcatcataa taatagctga     3840

cacaactatt atgggctggg gacttataag agctttcata actctcaggt aggaggcact     3900

acgaactcca tttcacaatt gaggaaactg aggcacaaag aaacgaagta gtgacagcag     3960

ctttcctttt tcccttcaac agtttggaat caagctgttt gagccgaggc tgggtctcag     4020

gaggtgtgga cagcacttcc atctcggtaa atcagattcg cctgcccata actggggaga     4080

atggtggctt tgaaaaggtt aacttgggag ccctggggac ggctgcaggg aacgtacgcc     4140

cattccccct aggaagcaga gccaggccgc ctcctcctcc gcagtggtga ggacgcgtgg     4200

acagtcccgc gggggcggcg ggagacctgc ggagtggccg cactccaggt ccgcgccaag     4260

gccgggcagc tccgctttct gctcagtctc cgcgaggtgt cgccttcggc cgaagaaacc     4320

accgcggcgc caccctcgta gctcgcactt atttatttat ttattttcaa acaagggggg     4380

cgcccctctt ctttcaattt gaaactggaa acatccagag gtcttgttcc taagggggcg     4440

cgtcctctcc ctgctatttt gcaccttcgg actacccttc tttcgtaatt acacaggagc     4500

aacctccctg caaggccttg ctcaacgttg gcctcgcgct cagctgcaca acacgcagtc     4560

aaagcggggg ctgggttaga agcatcggtc tcccctcccc aacacacacc cccggagccc     4620

tccgtaattt ttttttcttt taatgacaag caattgccag gctcgcaggg tgggtgctgc     4680

attgcaccgc tccgcgcgca gctggttctc agagtgcagc cggtgcaagc ccgggggtcc     4740

aaaagggcgg gaggagcaca ccctgggctt cccagctttg cagccttctc tctgcaaaga     4800

aaagcaagtg gcttttggcg cgaaagcctt ggcgcctccc ctgattttta tggaaatcag     4860

gagggcgggg taaagccgct ttcctctcct ttctccctcc cccttgtctg cgccacagcc     4920

cccttctctc cccgcccccc gggtgtgtca gatttttcag ttaataatat cccccgagct     4980

tcaaagcgca ggctgtgaca gtcatctgtc tggacgcgct gggtggatgc ggggggctcc     5040

tgggaactgt gttggagccg agcaagcgct agccaggcgc aagcgcgcac agactgtagc     5100

catccgagga cacccccgcc cccccggccc acccggagac acccgcgcag aatcgcctcc     5160

ggatcccctg cagtcggcgg gaggtaagga gcagggcttg caaaccgccc ggcgcccagg     5220

gaagcgacga gcgccggggc aaggcaagcc ctggacggga ttgcgacgtg cgcaccgggc     5280

gccctaatat gcccggggga ctgtttctgc ttccgaaaca aaaccatctc tgggttttcc     5340

cagaaaagcc agttccagcc ccgaaggcat cctggctaga ggagacccgc cctaatcctt     5400

ttgcagccct taccgggggg agtaatggct tctgcgaaaa gaaattccct cggctctaga     5460

agatctgtct gtgtttgagc tgtcggagag ccggtgcgtc cccaccccag gctggggttc     5520

ttctccaaag ggtgcccctg gaggaagaag agggggggat taggcagggc gaggccgccg     5580

cggtcgcaat ctgggtcacg gctgctccag cttggaggag aggcggctct cccggcgacc     5640

ctcctcgcgc gggcgcccct gccattcccg ggaacagggg ctcagcctct ccctccctgg     5700

aagaggacgt tgtcgtgggt ttggaagagc aggggtgggc ttagagagct tccaattaag     5760

ctattggcag gagtatccct gcagcgggtg aatgccgagg ggcgtttgct caaatttggg     5820

gaggggaagg atttgtggat atgggtgtct gttgttggtc tctgtctaga gaaaggcttt     5880

tttttatttg caaagttttc taaatcccct gctatcattt gcactcctga ggttgcattt     5940

ttacaaaggg ggtagaaggt actccaaata ccattcccgg tagctgggtc ggagagcctg     6000

gggcttcccc tgagcagccg gccccacacc gctgcgagtg cggttgtctg cgtgctcgtg     6060

agagctagaa ttctgcagcc aggaacagcc ccctccccca ggcagtgcct tgtgtgaatg     6120

aaatggcagt ttccaaagtt gcggagcctc gccaccaccc cctgcatctg catgccccct     6180

cccaccccct gtcgtagaca gcttgtacac aaaaggaggg cgggagggag ggagcgagag     6240

gcacaacttc ctccaccttc gggagcagtg ggcagagtgg ggggcttgga gggaagattg     6300

gggaacctgg ttagaggggg cgcccattgc ctatcccctc ggtctgcccc gtttgcccac     6360

cctctccggt gtgtctgtcg gttgcagtgt tggaggtcgg cgccggcccc cgccttccgc     6420

gccccccacg ggaaggaagc acccccggta ttaaaacgaa cggggcggaa agaagccctc     6480

agtcgccggc cgggaggcga gccgatgccg agctgctcca cgtccaccat gccgggcatg     6540

atctgcaaga acccagacct cgagtttgac tcgctacagc cctgcttcta cccggacgaa     6600

gatgacttct acttcggcgg ccccgactcg acccccccgg gggaggacat ctggaagaag     6660

tttgagctgc tgcccacgcc cccgctgtcg cccagccgtg gcttcgcgga gcacagctcc     6720

gagcccccga gctgggtcac ggagatgctg cttgagaacg agctgtgggg cagcccggcc     6780

gaggaggacg cgttcggcct ggggggactg ggtggcctca cccccaaccc ggtcatcctc     6840

caggactgca tgtggagcgg cttctccgcc cgcgagaagc tggagcgcgc cgtgagcgag     6900

aagctgcagc acggccgcgg gccgccaacc gccggttcca ccgcccagtc cccgggagcc     6960

ggcgccgcca gccctgcggg tcgcgggcac ggcggggctg cgggagccgg ccgcgccggg     7020

gccgccctgc ccgccgagct cgcccacccg gccgccgagt gcgtggatcc cgccgtggtc     7080

ttcccctttc ccgtgaacaa gcgcgagcca gcgcccgtgc ccgcagcccc ggccagtgcc     7140

ccggcggcgg gccctgcggt cgcctcgggg gcgggtattg ccgccccagc cggggccccg     7200

ggggtcgccc ctccgcgccc aggcggccgc cagaccagcg gcggcgacca caaggccctc     7260

agtacctccg gagaggacac cctgagcgat tcaggtaaag accgaactcg ggtccggctg     7320

cctccctggg gcactggacc ccgggtcgcg tcccctttgt tagtgctcgt atgtcttggc     7380

ctggggagca ttttggaggc agtgctaggg gcagagaggt cctgtttccc ccaagtctct     7440

cctcggggta aagagaaggg gctgagagaa tgccgttgca aaaggggtgc tctccaattc     7500

tcgccttcac taaagttcct tccaccctct cctggggagc cctcctctag gccatcacgg     7560

gccctcaccc ggtcccccac ctctcttttg cagcgcagtc tgaggaataa aattggagaa     7620

agttggtggc taaaccgggt gggggtttag ggggttgctg ggtgcactgc ctggacagaa     7680

acctgttagc gcaggggtga aagggactct ctggcccagg tcaggggagg gaaagacatc     7740

ccgagaagat tcaagggctg tgcaaagccc tgtttaaggc gcaggaactt ataggagggt     7800

tgcacagatg gctagagccg attttctatt ctttttcttt ttcttttttt ttttttttca     7860

aatgtcggta cctttccctt cccccatcct cggtgggtgg tgggctattt gctcctggtg     7920

cgtggccagc aggcggcgat atgcgaggcc agcaggcggg cccgggatct gaaaggctgg     7980

gggtggtggg ggcaccctcc ctccctccat tcagcagctg gctgcaagtg caacagcagt     8040

tgtgtacatt ctcagggggc ctcctctttc cagtgtgcag tggaaactgg ctgtagtttt     8100

gtcttccagc ctgaattcca ggcctaattt gagatgtgag ttgtatctgt aacccagtgc     8160

ccttgaaggt gagggcaggc actcagcagc ctctccagga aggctcacat cctgggagga     8220

ctcactgatt agttctattg tgttcatttg tctgtgtctt aagctgaagg gaagagttaa     8280

aaccaagcct ttccctgggg gtctggatga acagaactca acccaaagag tggcattgcc     8340

ttgtccttgg agcagggagc tgggaccccc cttggacttt gaaaaccagt gttttcagaa     8400

tgcaggtgga taacaagcct aaatttactt ctgggctgag gagagatctt tgaggctcct     8460

ggaaggaaac ttggtgataa gcctccagtt tgaaacggct ctgtcccttt aatgtctgtg     8520

ccttgacagc ttttggtgag gaagcacttc cttccaacag ctgtcttctt ggcagaaaac     8580

caaaacattg gcttaaaggg acccacagac tggaacagcc tcacatttcg gctttagaac     8640

aaatcccaca attgttcagc tttccggtcc ccttcagatc aagcagaaga tatgttttga     8700

ttttcatgct tgtattttaa acaataattt tctaccccag cgtggtagtc aatgaggaga     8760

gaggggaaga atgcgcacat gatgctacac gtttctgttg ttgctgttat tattggtggc     8820

tttgaggaga gctgctccca tttgggggtt tataccaact gtggattatg gctttgtcat     8880

taagatttga tctttgttaa atgaaaaact gtttattgta taaaactcag gtttgtggac     8940

gaaaagttgt tttttttctt cagttaatta aattgttcct caagtttgtt taaggactta     9000

aaatcaaaca caaccatgtg taaactgcta aatgaggctc ctaaaatgag aggcctcaac     9060

tctttaagtg tggagctaga aatgtaaata agtccacagg gcagactggt gattatgata     9120

aaagctacca tttactgagc atctgtctac taggctcagc tctatgctaa gtctacatgt     9180

tatctgtcaa agtggtatca tccccattta atagctgagg aaacagaggc ttagaaaggc     9240

tgggtaactt gaccagggtc atgcaactag tctgcggtgg agccaggatt ctgtctgacc     9300

ctaaaggcca agttctttat atttatttct accacctgct aaagtcttga atggaggctg     9360

aaagcacagt tggggtatgg ggaagaaaaa tatatataca tacatatatg tatatgtatg     9420

tatgtatgta tggggggttg ttttgttttt gtttttgata aggagttttg ctcttgttgc     9480

ccaggctgga gtgcagtggt atgatctggg ctcactgcaa cctccgcctc ccgggttcaa     9540

gtcattctcc tgcctcagcc tcccgagtag ctgggattac cggagcatgc caccacaccc     9600

agcaaagttt tgtattttta gtagagacag ggtttcacca tgttggccag gctgatcttg     9660

aactcctcat ctcaggtgat ctgcccgcct ccgcttccca aagtgctggg attacaggtg     9720

tgagtcaccg cgtccggcct acagatatat ttaatttaaa gagatctaaa acaaatacaa     9780

aactgtccac atctatgttg atggacccat aaaaatagca gtctgccagg gtctgccgga     9840

agagacagat aagcatacat attaacatgg atatatatgt gaatttcatt caaatggttc     9900

tcacatgaga gtaactagca tctttctctc agatgatgaa gatgatgaag aggaagatga     9960

agaggaagaa atcgacgtgg tcactgtgga gaagcggcgt tcctcctcca acaccaaggc    10020

tgtcaccaca ttcaccatca ctgtgcgtcc caagaacgca gccctgggtc ccgggagggc    10080

tcagtccagc gagctgatcc tcaaacgatg ccttcccatc caccagcagc acaactatgc    10140

cgccccctct ccctacgtgg agagtgagga tgcaccccca cagaagaaga taaagagcga    10200

ggcgtcccca cgtccgctca agagtgtcat ccccccaaag gctaagagct tgagcccccg    10260

aaactctgac tcggaggaca gtgagcgtcg cagaaaccac aacatcctgg agcgccagcg    10320

ccgcaacgac cttcggtcca gctttctcac gctcagggac cacgtgccgg agttggtaaa    10380

gaatgagaag gccgccaagg tggtcatttt gaaaaaggcc actgagtatg tccactccct    10440

ccaggccgag gagcaccagc ttttgctgga aaaggaaaaa ttgcaggcaa gacagcagca    10500

gttgctaaag aaaattgaac acgctcggac ttgctagacg cttctcaaaa ctggacagtc    10560

actgccactt tgcacatttt gatttttttt ttaaacaaac attgtgttga cattaagaat    10620

gttggtttac tttcaaatcg gtcccctgtc gagttcggct ctgggtgggc agtaggacca    10680

ccagtgtggg gttctgctgg gaccttggag agcctgcatc ccaggatgct gggtggccct    10740

gcagcctcct ccacctcacc tccatgacag cgctaaacgt tggtgacggt tgggagcctc    10800

tggggctgtt gaagtcacct tgtgtgttcc aagtttccaa acaacagaaa gtcattcctt    10860

ctttttaaaa tggtgcttaa gttccagcag atgccacata aggggtttgc catttgatac    10920

ccctggggaa catttctgta aataccattg acacatccgc cttttgtata catcctgggt    10980

aatgagaggt ggcttttgcg gccagtatta gactggaagt tcatacctaa gtactgtaat    11040

aatacctcaa tgtttgagga gcatgttttg tatacaaata tattgttaat ctctgttatg    11100

tactgtacta attcttacac tgcctgtata ctttagtatg acgctgatac ataactaaat    11160

ttgatactta tattttcgta tgaaaatgag ttgtgaaagt tttgagtaga tattacttta    11220

tcactttttg aactaagaaa cttttgtaaa gaaatttact atatatatat gcctttttcc    11280

tagcctgttt cttcctgtta atgtatttgt tcatgtttgg tgcatagaac tgggtaaatg    11340

caaagttctg tgtttaattt cttcaaaatg tatatattta gtgctgcatc ttatagcact    11400

ttgaaatacc tcatgtttat gaaaataaat agcttaaaat taaatgatgc aactcaacct    11460

tttccttaat ggcattacac tctgtccctt aaggagcaac cataaataat ccataaccta    11520

tagagggaat ttggtttccg taaatagccc tttttgcacc tgtacaatcc tggttggggg    11580

gcatgagtca ttgtccccac ttaaggtgga gggaactgag tttggggaaa ttaaggcagt    11640

tctccaagat tatgcagaat agagatgtta ttagcgacta ttgtgtgcat tgtagcaatg    11700

gcatttgata atttacagag cacttctgta tactgtggct ccttagtgga attaagctga    11760

gacctcagat cagtcccttt aaaagaaaag taaaaatagc cacagggttg tttaactcgc    11820

ttgtattggg ctttggtagt attcgtccca ttggcagaca gtcttctatt ttaaggtaga    11880

gcatagtttg tctccaagaa ttcattgtta aaaacattca ctaggatctg tggaggttct    11940

aggctaagca gagtaagcag aataaacaga tggaaatggg ttcctccctt caatgaactc    12000

aacctgattc accaaagtgt aattcacgag tgacagttac gtagtccaga gcaagtacca    12060

ggtgcaggag agaccctggg gtcacaatgg agaccccata tgggtggcat ggctctctac    12120

ttgccattcc tattacacag cagtgtcttg gctacttggg ctgccctttg gaaatgggat    12180

caatcttgca ggctccagaa gacagagcca agacttgtgt gttaaggaga tagtttacct    12240

gttgggacat aagagccttg cttgtaagca gcttctcaga actaaaagtg tacaaataac    12300

ctatttctct tttgagtgtc aggttgtact cggttatttc tctagggttt tgttcatctc    12360

agatttttaa ctgtgagccg aaaaaaaaga aaaaggcctt ttgcttcact gagaagaaag    12420

caggtccaga gatgagacag ctttgcttgc ctggacacac agtttgtcag gggcagagat    12480

gggagacacc aagccatgtg tccttgtctg ctttggtcat ttttatttgt ttcttttgag    12540

atggagtctc actctggtgc ccaggctaga gtgcagtggt gcaatctcgg ctcactgcaa    12600

cttccgcctc ccgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggactac    12660

aggtgtgtgc caccatgccc ggctaatttt ttgcagtttt agtagagacc aagtttcacc    12720

atgttagcca ggatggtctc gatctcctga ccttgtgatc cacctacctc gacctcccaa    12780

agttctggaa ttgcaggcgt gaaccaccat gcccagccgc tttggtcatt ttataaaggc    12840

aagtaggagt ttagaactca gtcctcctta tcctgcttat cgcacaccct tgagatacga    12900

ggttggtgat actaccatgg acatctttct gatggtctcg ccatgtagaa aataagataa    12960

aatgcccttt aattctccta gtccccatcc ccagactaaa aaataatgca ccctttcttt    13020

ttgaattgtc attcaaaaaa cttccgttcg tttgcatttt acaggcccca aatcactcac    13080

ggcctctgcc cctgtgtgtg tgcaagagcc aaaagaaagt taagcaacct cacattaatt    13140

gtgtacctaa gattcttgaa gcccagctca gtcatcccag tttctctatt tgtgattacc    13200

ataaggaacc tacctgagtg tgtccaatga aatggaatgc ttaaccgtga agaaagaaaa    13260

ctgttcatat gaatgaggcc actaaactac aattcctact atgctctctt tttgctcggg    13320

ctgctgggaa gctcagagcc aaattccacc ccctctaaca tctccagtgg tcattctctt    13380

ctaaatgttt acggtttctt gttttccatt gttaggttag tcatcttttt aatgtatata    13440

atgtagt                                                              13447


<210>  215
<211>  3624
<212>  DNA
<213>  Homo sapiens

<400>  215
aatgcgcctg cagctcgcgc tcccgcgccg atcccgagag cgtccgggcc gccgtgcgcg       60

agcgagggag ggcgcgcgcg cggggggggc gcgcttgtga gtgcgggccg cgctctcggc      120

ggcgcgcatg tgcgtgtgtg ctggctgccg ggctgccccg agccggcggg gagccggtcc      180

gctccaggtg gcgggcggct ggagcgaggt gaggctgcgg gtggccaggg cacgggcgcg      240

ggtcccgcgg tgcgggctgg ctgcaggctg ccttctgggc acggcgcgcc cccgcccggc      300

cccgccgggc cctgggagct gcgctccggg cggcgctggc aaagtttgct ttgaactcgc      360

tgcccacagt cgggtccgcg cgctgcgatt ggcttcccct accactctga cccggggccc      420

ggcttcccgg gacgcgagga ctgggcgcag gctgcaagct ggtggggttg gggaggaacg      480

agagcccggc agccgactgt gccgagggac ccggggacac ctccttcgcc cggccggcac      540

ccggtcagca cgtcccccct tccctcccgc agggagcgga catggactac gactcgtacc      600

agcactattt ctacgactat gactgcgggg aggatttcta ccgctccacg gcgcccagcg      660

aggacatctg gaagaaattc gagctggtgc catcgccccc cacgtcgccg ccctggggct      720

tgggtcccgg cgcaggggac ccggcccccg ggattggtcc cccggagccg tggcccggag      780

ggtgcaccgg agacgaagcg gaatcccggg gccactcgaa aggctggggc aggaactacg      840

cctccatcat acgccgtgac tgcatgtgga gcggcttctc ggcccgggaa cggctggaga      900

gagctgtgag cgaccggctc gctcctggcg cgccccgggg gaacccgccc aaggcgtccg      960

ccgccccgga ctgcactccc agcctcgaag ccggcaaccc ggcgcccgcc gccccctgtc     1020

cgctgggcga acccaagacc caggcctgct ccgggtccga gagcccaagc gactcggaga     1080

atgaagaaat tgatgttgtg acagtagaga agaggcagtc tctgggtatt cggaagccgg     1140

tcaccatcac ggtgcgagca gaccccctgg atccctgcat gaagcatttc cacatctcca     1200

tccatcagca acagcacaac tatgctgccc gttttcctcc agaaagctgc tcccaagaag     1260

aggcttcaga gaggggtccc caagaagagg ttctggagag agatgctgca ggggaaaagg     1320

aagatgagga ggatgaagag attgtgagtc ccccacctgt agaaagtgag gctgcccagt     1380

cctgccaccc caaacctgtc agttctgata ctgaggatgt gaccaagagg aagaatcaca     1440

acttcctgga gcgcaagagg cggaatgacc tgcgttcgcg attcttggcg ctgagggacc     1500

aggtgcccac cctggccagc tgctccaagg cccccaaagt agtgatccta agcaaggcct     1560

tggaatactt gcaagccctg gtgggggctg agaagaggat ggctacagag aaaagacagc     1620

tccgatgccg gcagcagcag ttgcagaaaa gaattgcata cctcactggc tactaactga     1680

ccaaaaagcc tgacagttct gtcttacgaa gacacaagtt tattttttaa cctccctctc     1740

ccctttagta atttgcacat tttggttatg gtgggacagt ctggacagta gatcccagaa     1800

tgcattgcag ccggtgcaca cacaataaag gcttgcattc ttggaaacct tgaaacccag     1860

ctctccctct tccctgactc atgggagtgc tgtatgttct ctggcgcctt tggcttccca     1920

gcaggcagct gactgaggag ccttggggtc tgcctagctc actagctctg aagaaaaggc     1980

tgacagatgc tatgcaacag gtggtggatg ttgtcagggg ctccagcctg catgaaatct     2040

cacactctgc atgagcttta ggctaggaaa ggatgctccc aactggtgtc tctggggtga     2100

tgcaaggaca gctgggcctg gatgctctcc ctgaggctcc tttttccaga agacacacga     2160

gctgtcttgg gtgaagacaa gcttgcagac ttgatcaaca ttgaccatta cctcactgtc     2220

agacacttta cagtagccaa ggagttggaa acctttatat attatgatgt tagctgaccc     2280

ccttcctccc actcccaatg ctgcgaccct gggaacactt aaaaagcttg gcctctagat     2340

tctttgtctc agagccctct gggctctctc ctctgaggga gggacctttc tttcctcaca     2400

agggactttt ttgttccatt atgccttgtt atgcaatggg ctctacagca ccctttccca     2460

caggtcagaa atatttcccc aagacacagg gaaatcggtc ctagcctggg gcctggggat     2520

agcttggagt cctggcccat gaacttgatc cctgcccagg tgttttccga ggggcacttg     2580

aggcccagtc ttttctcaag gcaggtgtaa gacacctcag agggagaact gtactgctgc     2640

ctctttccca cctgcctcat ctcaatcctt gagcggcaag tttgaagttc ttctggaacc     2700

atgcaaatct gtcctcctca tgcaattcca aggagcttgc tggctctgca gccacccttg     2760

ggccccttcc agcctgccat gaatcagata tctttcccag aatctgggcg tttctgaagt     2820

tttggggaga gctgttggga ctcatccagt gctccagaag gtggacttgc ttctggtggg     2880

ttttaaagga gcctccagga gatatgctta gccaaccatg atggatttta ccccagctgg     2940

actcggcagc tccaagtgga atccacgtgc agcttctagt ctgggaaagt cacccaacct     3000

agcagttgtc atgtgggtaa cctcaggcac ctctaagcct gtcctggaag aaggaccagc     3060

agcccctcca gaactctgcc caggacagca ggtgcctgct ggctctgggt ttggaagttg     3120

gggtgggtag ggggtggtaa gtactatata tggctctgga aaaccagctg ctacttccaa     3180

atctattgtc cataatggtt tctttctgag gttgcttctt ggcctcagag gaccccaggg     3240

gatgtttgga aatagcctct ctacccttct ggagcatggt ttacaaaagc cagctgactt     3300

ctggaattgt ctatggagga cagtttgggt gtaggttact gatgtctcaa ctgaatagct     3360

tgtgttttat aagctgctgt tggctattat gctgggggag tctttttttt ttatattgta     3420

tttttgtatg ccttttgcaa agtggtgtta actgtttttg tacaaggaaa aaaactcttg     3480

gggcaatttc ctgttgcaag ggtctgattt attttgaaag gcaagttcac ctgaaatttt     3540

gtatttagtt gtgattactg attgcctgat tttaaaatgt tgccttctgg gacatcttct     3600

aataaaagat ttctcaaaca tgtc                                            3624


<210>  216
<211>  101902
<212>  DNA
<213>  Homo sapiens

<400>  216
tgcttacata atggaggtgg tgggggccgt ctcaaaccct ggctggggag cagagagagc       60

ttaggccacg ggagagggca tgcctttgcc ctgcacgaag ctcctggcct gaagctttcc      120

ttcatccatg gaggtggttc attatggtcc ttcctttatg tgaccagagt cattattgac      180

agctgtgttc caaatccagc ttgcattttt aataaggtgt ccatgggggg aatcctgggc      240

aaatgggaag tgctgtggtc tgggtgtctg tgtctcccct gaaattcata tattgaaatc      300

ctaagctcct aggtgatggt atttggaggt ggggtctttg ggaggtgatt aggtcatgga      360

ggctagagat ggagcctcat gaatgggatt agtgcccttg taaatgacac cccagacagc      420

ggcctcaccc catctgccat gggagatgac cagacactgg gtctgctggg caccttgatc      480

tcggacttcc cagcctccag aactgggaga aacaaatgtc tgttgttgag gcctcccagc      540

ctacaatatt tttgttatag cagcccaagc taaggcaggt agccaaagga aagccaggct      600

tttgtttaat cagtagcagg gggtcagtgt tcaaagttta gttaaataac taaatgcaga      660

atctcattct ccaatagggt acaatcaacg caaagcccag ctctttcctc tgcctttgac      720

ctggagctgt cccatctgaa tttatgctgg gggaggacag atcacccaag cttgacaatg      780

gttcacatag catttcatct cccggtatct aggtgacacc ctaaaggccc tccctctgtg      840

caaatactcc cccagactta gtctctccct ttcctcattt tgctaaggat agtggcccat      900

tttacttcta aaacaagttt ccatcatttt caaatcatga tatacttgga atagaatcca      960

tacccttttg tccagccccc acgtggaatg tggtctctac cacccttcct gggctgggct     1020

cagctgcctc ccaggccagc tccctgcttt gtggccacag tttcctgtca gtttcctcag     1080

cacacctggc tctgggcccc acaggacctt tgtacaagac ctttggtcca tctgaaacac     1140

cttctgccca actctgcagg actgccttct tccttcgcaa gtcttggtca actttccttc     1200

tcaacaacca aagcaccgcc cctcacaccc ccttaccccc acatcagctt gctggtgtcc     1260

gccgtatcac ccaattccat tctcatattt taggcacatt tgcaagccta ggaaggtgtg     1320

gttcctaaga gagactttaa atcacaaata tttatattcc tgttttttct gcctatggaa     1380

ctgtgaccac atgagtagcg ggtgctctga gatgatactt taaaaactag ctggccagtg     1440

ctgaggaggg cagagccctg tgaggttacc actgacagag ctggggacaa acgcatttta     1500

ggaaagcaaa gaagccaggc caggtcagtc ctgggagcca ctgtgccacg aggcaggggc     1560

aacgttcttc cagaaaacag tcccagttgt gggacaaatt tgaagctgca aactctacac     1620

tatagacaga actgtgatca ttttattctg aataacttag tgggtgtcac catgagcata     1680

aaaacatttc atcaaatata cacacactgt gttaggattt gagcaatgtc atttcctgga     1740

aggttttctg agatagactt cacctgcagg taaccagaag tttacttgct gtggtgagtt     1800

gttaggtgaa accaattata tgtcagggcc cagctgccag acaggagcat cttgcttttg     1860

gagtgtttga ttcccctgcc actttttgag acagtaatta gtagcaggaa actgtcacca     1920

gccaactgat aatcccctca catacaaaca caaataatcc aggcatcctg tgcacccttg     1980

cttatcacgg ccaagaagta cttttcatct ccatttcata acttgattac tctatgcctc     2040

cccaaacaga gcataagctt cttgaggcca gcgattttga ctgttgttct cattgtgatc     2100

tacccagcaa ctggaacagt accggcacgt agaagacgtg acgtgcattt gctgcatgaa     2160

taaacacatg aacatgatgg cataggagaa tgctactttg atggggtaca tgggtatcaa     2220

ggattttctt tctgctcaca caacatgaga tttgtaatta agacacagat ttaaggtgag     2280

tccggtggct cacacctgta gtcccagcac tttgggaggc tgaggcagga ggatcacttg     2340

aagtcaggag ttcgagacca gcctggccaa catggtgaaa ctctgtctct actaaaaata     2400

caaaaattag atgggagcag tggcacatgt ctgtaatccc agctcctcgg gaggctgaga     2460

atcgcttaaa cctgggaggc agaggttcca gtgggccaag atcacgctac tgcactccag     2520

tctgggcgag agagcaagac tctgtctcac caaaaaaata aaagacacaa atttaaaatc     2580

acgatgacca gaatatggct ctgtttcact cactggaaat tatctgatct gcaagataat     2640

tcttaccaac ccctgagtgt tttttacagg gatgggagtc cattgactct ctaaaatcac     2700

ttgcgaagtt ttgttgctgc ggagctgaga gctggggcca gcctgcctgt tgtgcccctc     2760

cataagactc ctggccatgc atttgagcac acctcatgaa gggggcaggt ggctggccgg     2820

gctgttatgt gtagcaagca tgtgttctaa attacaattc atttgttcta aattacattc     2880

atcatttcta aatttgttct aaatttagaa cacagcccca ggagaccccc ttcacccaac     2940

catgttctgc agtcttgatt cattttctta cttaaaaaat gctattgata acctgttgct     3000

atttctgcct cagtctctta ggaaatgtat aaaacagaaa atcacatatc ttcaaagctc     3060

tggagcttta catgatgaag ataagcaatg atttctcatt tcattctttc tcttaatcaa     3120

ctgaattaat tatatactca ttttcatttg gatatgatga ctaggcagac ttcaagtata     3180

accatccata accttgctta atgccatgat gtttggattt ttttcaaaga gaggaaaaaa     3240

ctcccttggc ttctattaca gcatccatat tttgtgccat tttaattttt tcttgtgtct     3300

tttttctctc tctttgggaa atatcagtat cattcctttt ggtaaatttt aaatcaccac     3360

ttaatttcca atagaaaaaa tgttttagtt acacctaaaa taatcccaaa cctcaaacac     3420

actgtgagca caccagaaag taaaaattat atggagtaga acagattagc ccagaatacc     3480

tcccattcat tttcccaggt tcctaattta ataatttcag tgactttaat ttatcacaga     3540

ccctcagtct gaactcggca tgagcagggt agacaaccaa acctgaaaat tcaagttaaa     3600

attcttgttt gggagcttat attatctaga ttaatcatcc acaaggatca agtcagctaa     3660

gtaactctgg ttcagcttaa tctctgtgga ggcagaatta gtcctttaca gtctaggtcc     3720

ttgccccagc cccatacatt tctgtctgct tttttctttt cttttctttt ctgttttgag     3780

acagattctc gctctgttgc ccaggctgga gtgcagtggc acaatctcgg ctcactgcaa     3840

cttccatctc ctgggttcga acaattctcc tgctttagcc tccacacatg ccaccaccgg     3900

ctaatttttg tatatttttt tttttttttt tttttgagac ggagtctcgc tctgtcaccc     3960

aggccggact gcggactgca gtggcgcaat ctcggctcac tgcaagctcc gcttcccggg     4020

ttcacgccat tctcctgcct cagcctcccg agtagctggg actacaggcg cccgccacca     4080

cgcccggcta attttttgta tttttagtag agacggggtt tcaccttgtt agccaggatg     4140

gtctcgatct cctgacctca tgatccaccc gcctcggcct cccaaagtgc tgggattaca     4200

ggcgtgagcc accgcgcccg gcctaatttt tgtattttta gtagggacgg agtttcacca     4260

tgttggccag gctgatccca aactcctgac ctcaagtgat ctgcccgcct cagcctccaa     4320

agtgctgggg ttacaggtgt gagccacgga gcccagactg tttctttctt aagctcttac     4380

tttctcatgt gtgagttacc ttgtaggttt ccaaggcaga ggggacaaga tggaaaagga     4440

gaacacagaa atctagcctg gaggagctgc tctgttcctg tatttatctg tgtaggtgtg     4500

aatgagggag aaaatgacaa gagaatgaca ttattttaag gctgttttcc cccccccaat     4560

catttacttt ttgagaaata attgcccaat actgaaaggt atgtcctttc aaaatgttga     4620

tgtttcaaat ggcttcctaa ttacctagtt atacgggggg tgtgtatggt tatctgaagt     4680

tacatgggta tacactggtg gtgtgaggtg tccagagaga ggaaaggaag agcagtcctg     4740

gtggctcaaa ccctgaggga tgtgcggggg atgggtgaga atgtgaacag acatgttgga     4800

agctgaatcc gtgcagtggc acccatgcct gtagccatct cagtgggggg tccttctacg     4860

aacaagcttt gattaatgat attttaatgc tagtttagct ttttagcact cccacgccta     4920

aaggctctga tagaagcaag gcccccaccc ctgcaaaaaa aaaaatccat gatttttacg     4980

cattccaaca gatctcttaa ggggcagacg gccggagagc caggtgtgcc agggacctat     5040

ggcagcaggg ctgaacgtgc ccgctccagc ctctccagtg ctgggagaga cctctagatg     5100

gtgcaggtga gtttgcaatg agggaaagcc cctcggcaag gactgagttt ccaaacttgc     5160

agacagggca gggagcggtc aaggaagagt tcccgggaag ccctttaaac ggaaaggaag     5220

cggggctagt gtcagagagg tgtgccaggt cccaggcagc cctgctggcc cctaaggaca     5280

tagagtacct gcttctgaga gggctgccac ggtggccacc tgtgaagcct gtcacccaga     5340

actggatggt acctgacttt cttcatagac ccatcttctg ctgggactga agctgacctc     5400

caacagaagc caggtaagcc ctggtccttt cctctggttt tctaaactct tcagctgtgg     5460

ccgagacgga ggtgtcatgg gctgggagag aggctgggtg catttttgaa atgcatgtca     5520

tttttgggtt gcgtttgaac aagctttacc gattgcagta tgtctgcgct accagttcta     5580

agacctgaga ttgttccttt gttttagaaa aacatcagaa accctgtttt gctgttggtt     5640

gcacatttgg ttagggagac aaattctgtg tgtgcttcac aggctttaag atttgggcta     5700

ctgaagcaac gggttcctcc agggagcgtg aaaagtatgt ttctcaggtt tgcccctgtg     5760

cccggctcac tggggaaggc aggcgcggca gggactctag ctgggctctg tacctgcctc     5820

caactctgcg tacccgctgt gacctaagag accttccaag tggggtttcc agtcgtgtct     5880

gagacccccc atatcctggc ctctgtgttg gtggcggggg agcggggaga gggagagaag     5940

gaggggagtg ggtacctatt tgtgatgatt gaggttttca tttccagcca agaggttcct     6000

ctcaacactc tgacagaccg tggggtgggt tgggctccta gacaggagtc ggctctgatt     6060

cagtcggctc tgattcccag cctcctgcag cagccaagct ttgagatgtc agctcaggga     6120

gaagcgggtg gctgggcagg gaggtcagca ggcgaggttc ccactgggtt tccctgccca     6180

tgttgtgctg ggtcagcaac aagagggaca gttaaaatca acaagcaggg cagatgccgg     6240

tcagtgggca atcccacaca gccaggggta cacgcatgtg aggagacgta cggagagaca     6300

ggagcaccac cgtcctcttc cccagtcccc aggccactgc tctgtggctc tcaagtggca     6360

tttttgagac actttctaag caagagtgaa agtgtaacaa agaagtgaag agccataata     6420

gactgaagga aaaaagggat ccaggcatct aaaatagaga atgtttcttg cctggcttaa     6480

tactctgaga tttgtaagtc atagccactt aaaaccttta aagatacatt ttgacagagg     6540

ccaccaaaaa gagagtgact ctggtcaagg cttggaaata agcgttcgtt ccgatgacag     6600

tccacgtgta cccttcacgg ctgggaaagt ttggcgatcc tggtggcgat tggccggggg     6660

tctccactgt acccctcccc atccctaagt gggccaggct gtgctgtggg aggattaatt     6720

tgtgacagca cagttggagg ataatcttgg aaggaccagt ctttgggagg aaaaagtaaa     6780

tacactttcc ctgaaatgct tgattttcac tccctggcca ctacctggtt tcttgctttt     6840

gtgagctgga ctttcatttt gttgggcata cacatttgtg aagcacagac atgtcagggg     6900

ctcatctttg tttctcaggc atcatggtac cctcttgcct agcccagtgc ctgccattgg     6960

gcggcagccc aacattgctc cggagtgcag acagacctgg tcttacccca tctcacggag     7020

cgcaaaacct acttgcctct gttaaatggg gagcctcttc tagtcaaagt tcctcaggtc     7080

tcataggccc acagatggaa gctgggttac ctgacgctcc tttctgggtc caagtgagtg     7140

cgttttgtgg tttccaaaga atagaattta ttctcaagga aatgcccagg aacccagctt     7200

caaagactca agcaaatctg aaattcaaat acaggagctg taaacaggat ggtgtttggc     7260

agacagcctt gctgcttaag tggctcagcc cctcagctgg gctcagtttc ccctcaccct     7320

cctcctagcc tgcctagtga ctgcctgcat gcctcaatta tcctggatga cacctgcctg     7380

ctcgttcctt tgatgctgtt tgaggctctg cctaggtatt ccacccacca atagtatcat     7440

taattaactt acattaagcc cacttagcac attagatcaa ttaggggaca aaagccccag     7500

ccagcctttc ctgtgagtat gccgcctcca tctcaatgcc tacgattctg tccttactga     7560

attcgtatat tgcaggaagg aatttttttt aagtcccaaa gattactatt ttcctaaaaa     7620

ataaagcaag gaaacataag ctgatgtcta atcatttaac ctctgctgta catttctatg     7680

gcactttaca aagcgttgtc atgaatgtct tctctatttt cccaataagg aaattgaggc     7740

tcagagaggt tcactgtctt gcccgaagtc ccacagctca taatgattat gggaacacca     7800

agaactggtc taggttagca ctcagtatgc ccaggcctcg tgtggagcct gtcactcata     7860

attggagggg ctgagactag aacctgtgtc ctctgcctcc aacactgaca catttgcccc     7920

cacaaggaga tggtgcaatg acagccacca gggattataa aaataagagt ggagtaagca     7980

aacactcccc ctcctgtatc ttagtttccc agggtcgtgt cagccccaga cacactcatc     8040

tcctgtcctc agaggcgagg gatcaagagg aaacagtctc agttttgttc tttgtgaacc     8100

ctcctgataa aagttagagt gtttgtagtt tttatatagt gaaaaaaact gtcaaatata     8160

ggccattgta ggtggttcag tctaagatag tctagtaact aaaaaaaaac tcaaaatggc     8220

atttggggct caggcatccc aacagcccac tggcccctga gacaaatgag cttgaccata     8280

tttaattttt catcattgcc cttagagtgt cacaaagcat tacccaagga tagctgaccc     8340

tgtacagtca aagctatgaa aaaagctttg ccctgggtct tggcagggat cagccattca     8400

ttaggtcatg tattaaggga tcctacaacc tgaagtgtct tcagtcatag cacaccccaa     8460

ggacatcatg cactccatga aaatatgtcc aatgaatgaa tgaatgaatg ggctccttca     8520

tccttcttgt cagagaaagg tcaccaattg ttccaatgac acagttaggg acaagggggc     8580

tgctcaaaca tcagcatccc ctaagtcaat aagcaaacaa atcctagtta gcaaagctac     8640

cctctctggg ggcagagaca cctgttattt ctcaaatgct ggatgcccaa gggtggcaaa     8700

cacactgttt ggaccccagg aaggagcaga cacatgtggg tgaagctgga ggtcctgctt     8760

ccttgcccag atcctcttgc ccagacacac tctggaaatg cccatcattt tatacaccta     8820

cgtacacatg taaccagcca ggatgccttt gttttccatt tccgagaaaa cagaggacta     8880

tggaaaacag gtgggccgta aggagcccta cagaggaaga tgcacctgtg gcggtagccc     8940

tgcctgcacc accctgcgag ctcatgccag cttaactcac ttcacggtca atcagaccta     9000

ctgctccaaa cacagtagga aggcgcgcct tcacttgtga gtcggacgaa atcagcaatg     9060

agggcaataa caaccacagt cacgttactc ttagtaacag ccctgaggcc cgcagtgtag     9120

cacagaagcc aagcttagtg gtgggcttaa ggctgatgtt gttaactgat accattcaat     9180

agctagatat aggcaactaa aaggtgagcc caaatactga aataagatac agtattagtc     9240

tcctgaaaat aaaaaagagt tgattctgcc aacaacacct taatcctgag agaaagcact     9300

ttcttaggat agaagaaaga catgcaaaac cagactgcaa gcaaaaaatg agagggcatg     9360

cactgttttg acgactctca gatggttacc aaatctcttc tcttaaaact tccatttgcc     9420

atatttccaa tcccatgttt gcacagaatc ctgcatgcac aggaggaagc aggcaggatt     9480

tcaagttggt tttagtgcac attcattcat tcagcaaatg ttttctgggc atctgctaca     9540

tgccaggcac catgctggga tgtagtgagt aacacagtgg tcccatgggt gaggagagag     9600

aacatccctg cactcacaga gcttagattc tgctgcaggg agagaagcta taatgcataa     9660

atccagcgcc atgaaaaaaa aacaaacaaa ctagcagggc aggtagaaag aaggtgccca     9720

gggtagtagt gggggcctct tgggaaatga aatagttgag taaagacctg gatgaagtga     9780

gggagtgaac caggacaccc gcaagaaagg aggccctggg gtggggtgag ctggagatgt     9840

cccagcacca gcaggaaggc catgctgccg gagcagaggg aaaggagggt tgaacagaag     9900

gagaggagag gagaaccagg agcctgagcg ggccgtggca agggggctgg gctctcattg     9960

agggtgatgg aaaggcaaac agaagtcaag tcagggcgga agttcagcca tggtggctca    10020

cgccctgtgt tgttctggga cagtcagtgc ccacaccacc ccatcccatg ccacgccggt    10080

tgctgtaatt tgcttctaag gagctgggtc tccaagtagc ctcttcctgg gagagttggc    10140

ttggctgagg tgcagggcag gaagggcagg cagcaggaag ggtggcagga gaggaatgat    10200

ccattttcac caacacctgc tcccttggcc gttaacacat gccaaaggga tccattctga    10260

gaaaaattat gaagacccta acctgaaaca catgattaca cttccaaaaa tctgaaagta    10320

gattatcaag actcaataag ttgtgcagag aaagaacact tagcaacaga catcgccgtc    10380

gccccccttg cagccctgct gggacactcc cacagtcgca gagccactgg ccagctgcac    10440

tcgcttcctc ctcacttgga gagagggaca ccttccagca tcgggtgtga gatggagtgg    10500

ggacgcagtg gctctctgat ggctcagttg gcaaaattgt tggagaacgg gttcagagat    10560

cactgatgcc cttggccagc atgccagacc tgttcctgtt gactccatat ggcctttgga    10620

gttggagaga aggtggcttc cctgccccgt cccgcacgga gccaccagca cctggaaagt    10680

ttgatttcct tcctcgtatc tggaagatgc aggtcgatta ggagggaagt cagtctggag    10740

gaggatacct gtctctggga actccagggc agtcaaggca gacagatgga tcacgaggga    10800

ggagctggaa gggcgggatt gttgacttga tgtctggttg gggtctgatg aatacaggaa    10860

agtggaaggc cacggggaat gctccagtgg gatgcagatg tctattaagt tggctgattt    10920

tatttaccca gttagatgtg gttttatggt ttactgtttg gattgaggct ctgtgtcctt    10980

gggtaataaa cattacctct ggccccaaaa aatcctaatc cttaaaaata tggaaatgca    11040

ctgagcatcc ctaaaaggta ctttagagga gtctcaaggt tcattttctt taagatttag    11100

tccttaataa agactcaaaa tggctgttcc taaagcctcc tgtccataat gaagaagata    11160

aatcagagtg tacactttgg ggatgtgttt gttgacatgc ggcatcctct gcagaaagcc    11220

tgtatctcca agaagcgtgg ccaagggagg gcactgacag ctgagtttag agtgggattt    11280

gtaagcagca caaactaatt gtgcatcggt agatttgcag agtgtggttt tctgttgatg    11340

gatttcttta tgggcaataa aatctccaat aagtaccatt tacattcagc agaactcttt    11400

ttgaatttta gctcattctt agagagattt ggagagagag agaccatccc tgcacatgca    11460

gcaggcacct ggcctgtctg ggtggccagt ccttgttctg tggccactgt gaaccccgcc    11520

aatgtcctag tttcccgcca gcactcacta agcaattttg cttctcattt tacgggcaga    11580

cgtaaccaaa gcaaggagac ttaggtgact cgggacactc ggttttgagt caattctaaa    11640

aaccaggaga ccaaactttc tctagaatta ctgccagttg gtttccaaat tgaggtttcc    11700

agatgaaaat tattatccaa acagaccaca cacagcactc tgacttgcct tctgtgcctg    11760

gcatgtgcga gggaaatggc gctggagaat attatcctga tgattatcac agttgttgct    11820

tttgaaggca aatatttatt ttgtgaagat tgcaaaatga agtacaacag aatgttgagc    11880

tcctccttat gtttacagaa taaacagaac tgagacactg gcaaacgcca atgtccctag    11940

ttcttaaagg actggctgca tgcctcccac ggcatcagtt aaagcaggag cctctggaga    12000

tggaggcctt tggtggcagg acagcctccc accagggagg gtctgaggct tccacccacc    12060

tccctgggtt catctctgta aacagctctc ccagtgtggg ctggatgggg tttgaggtgg    12120

ctgctttcct gtttaccctg gaacatttct ttgttagaga ggccactgca tttgctgtaa    12180

gacaacgggc tctagatctt tctcaaggct ttgggagatc taatagaaat aaaagacctg    12240

gcccctattc tcatggccta aagcattgaa aggaggaaat aggagagata gccaaattgc    12300

atggtgctgt tactgagccg ttaaacatct gtccctgccg ttgcactgac tgtgccctct    12360

ttgaggacgg gaagcatccg tctgttcatt ctctggcacc tagcacagtg gctgcacaca    12420

gtaggtattc aataaatgtt gaagaaaccc acatttattg ggcatttgtt gcttccttag    12480

cgtttccgtc ttaatctgca cagcagtcct gtgaaataga gacaatcatc actgcttcac    12540

acatgtgcag agtaaggctt ggagaggtga ggtggcttgc ctgagacctc cctcctggta    12600

agttcatgga cttcgccttg ctgtcgtttc catgggctcg ttcagaaatg agagctggga    12660

tgatgtgggc tgtttcaaat tagcttgaag tctaaccttg tatcataact atctcgggtg    12720

tggggatagt atatatcgag cagaggtcta ggtatagaca gatgtgtgaa atgctaaaca    12780

tggctgaact ccccagagac acctcagcag acagccctgc tggctagccc cggatcctgg    12840

acaggtgttg tttgggctgc aggatgctgg gagctagagc ggaaaatgga agcttctctt    12900

tgtatcccca aggccaagag cagacctggc cagccattct tctcacaata gcagtcatac    12960

cagacctaag acgcgccaga caacttcaac ctcaggagcc tttcttcttc cctgaagttg    13020

gggtggactg gtcctggtgg ggttggactg gcatgggcta gccacctggg gcgggtgcgg    13080

ctctggaaag aatgctggcg gcagggtggg gaggagccca gcctcaggtg gacacaggcc    13140

cagagccagc cccttcccgt gctggtggtg gaacgtcaga tcatcattgc tgggtaactt    13200

ctgtcacttc agttccccga gggaaggtca catacttgcc tcatgggaat attatgtgga    13260

tttccgagag ccaaggcagg cagagtgctt agagcgggcc gtgagcacat tggaagtcct    13320

gctcatgctc tgtatgcact cacgggctga gtttaacggg tcagctcaac ctctgcctgg    13380

cagtcattcc cacggtctag tccgtcagag gtccctgtct ttccttggag cagtctatca    13440

atttggccag gtttcaaaac accatgagga ccctgcagtt aaggggcagc tacacggggg    13500

ttggtgtggg gacacagcag gctctgccag cccccatgga gtatggtgcc aggttggcca    13560

cctccccacc agtgacaccg tgaccccact ctggccacac tgattcaagc tcagggctgc    13620

cgcatttgtt ccctctgccc aaaacgcgct ggcccaagat gtctgtgtgt cttgctcatt    13680

cccttcaggt ctatgctaac acgtcgtctt atcagagaaa ccctccctgg ccccacactg    13740

tataaaacag cagctcccac ccctggactc ctgttttacc tttatccata acagtgtcca    13800

ctcaacgact tatacatatg catgtaatat cacataaata tatatatgta aatatataca    13860

tacacacata atatcacata agtattatat atatgtgaat atatatatat ttgaacctag    13920

aacttggtga gtaataagta ttagtttaaa atcacgactt gctgctgagg tgagcggcag    13980

ggcgtgccca ccagagcatt agtggcagtt tcctccttgc tctccagagc ctcccaaggg    14040

ggcttttgct ctcctcacct tcacagaggt ttcgggatgt gactcacctg ggcctccctg    14100

ggattctctc actgcagaac tgtccggaat cagtgaagca aatagggaag agaatgaaat    14160

gagctggggt taaagaacaa ccaggagacc ttgaaatagt aaagtatcag gttgagaaca    14220

gagaaagtgg tgagtgactt gcccagcccc ccacccgacc ccaccccacc ccaccccaca    14280

ccattcattt gaacttgacg atgggcgatc tgttaagtgt gagtgtgtcc atggtcactg    14340

atacagcaag cttgagaggt gaatgcatca cactgatttt caagtgaaga agcagaggcc    14400

aggagactca cttgcacacc tcatctcagc caggataata gagccacagc accctgcttc    14460

ccaccgccca gcagtgatgc caggtgtccc ccctacccgt gtgctgcccg tcagagccag    14520

gctggctgtc agggcctagc aggaagcatg tcatgtcaga tggccaaagt gaagaaactc    14580

tattcaaggg acccatttgg ctggtgacat gcgcctcagt ggctcctcct ctgttggcta    14640

ctgctgcctg gacctgctca agccctcctc tcctctgcag ttcctgccat ctgcatcctt    14700

catgattaat ctgaccctgg gtagggaggc aggaggggct tctcttctcc acagccctgc    14760

acctcagcag catggctcag ggtctccaag tccccagccg ccacctgaca tgcccctagc    14820

ttactagctt gctttctcca gcccccactt cagctcctgg ggtgtgccat gcgtgtgtgt    14880

gtgtgtgtgt gtgtgtgtgt gtgtgagaga gagagagaca gagacagaga gagagaaaga    14940

gagagagaga cagcaaccaa agcttgggat ggggcttgga ccaggctggg ggaagtggtg    15000

gggcaggggg cagcccaggg tcagccccag caaacaagag tgttggagga gtgaggttcg    15060

ccaaatggaa gaggcaaatc tgactaaact tctccaacca gatgacacct ttaattctgc    15120

atgtctgggc tctaagacgc agattctcct tttacccaac agcaagaaag agctgttcct    15180

taagtaaggg tcaagtactc gggcagtgga tggagaaaca cagtgagagg aggggcagcc    15240

ttggcatcct cagatgtttc cacgtttccg aattttcagt gaatctggtt ttccacaaca    15300

ctgaatgttt ttgaagctgg cacctctctg cttactgagt agatgcctaa ttggaaatgg    15360

aatgtctgta cttcacacac tacaccccct cctgcccctg ctgagaactt tcccgggtta    15420

atggtttcct tttggaaagc tttcaaatgg tcttcgttgg agtttacatt atctgcttcc    15480

ctctgctctg tatgtggatt atttgcctgt tgggtttaat ttaaccagat ttgcagctgt    15540

gctaacaact tcattggtgc cctcctgctt tcagaatgga ttttcccgtc ttttctccag    15600

cttaccgata gactgtctcc ataccaaaac ctgcacgggg ttgggcattg tctgctggtg    15660

ttctgcctca ctacagaacc tgtttcctct gaccaaactt cactgcacct caggttctaa    15720

ctaggtctct ctaatatttt aatatgaata gttaaaatga attatttatt aaaaatcact    15780

gttaaacaag aaaaaaaaac ttttcctcgg tgctctgaac ctcagcctcc ttgggaggat    15840

ctgcatgttc cctaagcccg tggctccctc ggagctctac cctctagaaa tacgttgcaa    15900

aactcttgag gcgtctaaca aatatgacaa gcccacagat tagcaaagac acgcagagtc    15960

gaccaagttt gatatttttg tttttttact gagctttttg tacttaatag gagacctggc    16020

cacctaataa gatggtgatt attggaaacc acagagatgt aatcagatgt tctagacatg    16080

gatggtgtat ttaacccctt gaaacacttc cacgccctgc ctggatcctt ttctgcttca    16140

tagaccaatg atgagttcct aaaagatatg cacgtctatc cccagtgaag gccgtagctc    16200

agcaggccct gtacttggca ttacaggggc gggacctgtg tagccttgcc ctctggggcc    16260

ctttgctggt cttcctaccc tgggctcttc cctatgtcag tgccatttgt cgggagaagg    16320

aagaacgact ttgaaccgca gccctgttct gtggatgaag ttggctggag ttcctctacg    16380

agaatagaag ctccctgagg agtttcatct gcatccacag agtccataga tcctgcctat    16440

agataagaga ataagcaaat ggctgttgtt tctttactgt gtcatttaat atgatgtctt    16500

gtggttgatg aaggcttaaa aagtgtgtga accagaagta gaacaagaaa agagggtgcg    16560

gctctcagca ggaactgtcc tgaggtggct gtgggtcctt cagacactga ggcctgtttc    16620

caccctcagc tctgaggcct tctgttcact gaggaatctc cagggctttg tcagcatttg    16680

aaacaacagt gactcctagt gagagccggg tcccaggagg gaggacgtcc agatgtcccc    16740

agtccctcct cactccaagg aacagtcttc cacttcagga acactcaaaa aaggcgagct    16800

cctggccagg ctcggtggct cacgcctgta atcccagcac tttgggaggc cgaggctggc    16860

ggatcacgag gtcaggagat cgagaccatc ctggcgaaca cagtgaaacc gcgtctctac    16920

taaaaataca aaaaaaatta gccaggcatg gtggcgggtg cctgtagtcc cagctacttg    16980

ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgc agcttgcagt gagccgagat    17040

cgcgccactg cattccagcc tgggcgacag agcgagactc catctcaaaa aaaagaaaag    17100

gcgagcttct caggagccaa gctgagaggc caccagatct cccggcggca aaggcagtgc    17160

tgatggtcca tggggtggtc aggggtgcag ggcctgttgg caccctttag ccttagccat    17220

ctaggaaaac ccaggcccgg gccagtgggg gccactggaa tcatcagtgc ctccttattg    17280

gcgtcctgat cacagcacag gtgtctttct aaatgagagc ttgttctttc caaactggga    17340

agtcagaggt atttggggca ccctcagaca ccttttcatc ttagcatttg tcagtcctca    17400

ctgtgcaccc agatctggga ttctaatgcc aatctccagt gaaaggaacc aggactcctt    17460

ggagaagtgg ctgactccag agctggggca gggaaaatac aagaggagcc tggagcacct    17520

tgtagtgcca gaaagtaaag aggtcctaag aaaagaaaaa gaagaaaaag aaaaaaaaat    17580

ggtagtatgt ctaagggaca cacaaaccaa ctaaaagagc tcccagtcac catagctgag    17640

acaatttgag caacaaaata aataatgtaa tattgggtta taacccagag tttaaaataa    17700

atacccatgt gttcacactg acaaataaat aatggacgga tggacaaata cataacagag    17760

aagaggcagg tctcccgtgc agaggaactc caggtaattc atgtagatgc tgtgcccttg    17820

aggaggttaa acggataact ccctccctta agtgtgcgct ccgcctggag acttccttcc    17880

aaggagcacc ggaaggagtc acttcagagt ggggaatcct gccagtcact gcttcatccc    17940

agtgatcaag gccagcatca gcaatcctga gccatgctgg tagcatggac ccttcatgtg    18000

atgagaatgg cacattgcct ctgtggtctt cctctcaaac ccatagcccc agtctgtcac    18060

gagaaaaaca tctgacaact ctcagttgag gaggattcta caaaacacct gtccagtgct    18120

cctcaaaact tctgagtcat caaaaacaag gcaagtcaga aattgtcttg ttagccaaga    18180

agagcctaag gatgtgtgat gattaaatgt aaagtgggat cctggatggg atcctggaac    18240

agaaaaagaa cgttaggaga aaactaagga catctgaaga tgtatgaact tcagttcacc    18300

agtattgcac cagtatttgt tcatcaggga tgaccactgt attgcatcat gtaagatcct    18360

aaaaggaaaa ctggtgtggg gtccccggga acactctgta ttgaatttac aacttgtcta    18420

taaatctaaa actgtcctaa agcagaagaa atcccttgtc tagatgattc agtcaccctc    18480

ctctttgccc tgccctttcc accatccaca gaacgccgtc cagcagttga ggggtggcct    18540

tgacttctcg agctcgttca ggagtgacca caagacatcc tgatgccgca cggagcctgg    18600

ccgacagtgc cacccttctc ttgctggacc aatgaatttg tgtcctcatg tcatttcctc    18660

cgaccaccac agggctctgg ccaggggctt cgcaagctcc ttagctccca gaccgcaccc    18720

ctgttccccc ggctctattt taggcttatt ggtgctggct gcctccccaa agctgctgcc    18780

ctgcttccag tgctggggta ggaatgagct gagcctacag tccacccacc cacctcttct    18840

cactccggca tccatctggt caccaagcta ccgcgggttg acccaggcta gggtcccagg    18900

ttaaagtaga cgcaggtctt gctctcatgt gctggcgcta tccatgtctc gccggcccat    18960

gctccagccc tctccctgat gctgtgccca gggctgagct gcacccacaa gctcccttgc    19020

ccccagcctc cagctggatt tgacccatag aagacacggg tgggaaccca ggcaggagca    19080

tggtggccgg caggggattt actctgcacc tttctgcctg aggccgcagc tgctatccct    19140

gtgttcagat cctctctctc ctttgcccct tcccacacag gctggactgc agctcctgga    19200

gtgctgcacc atcatttgct cccctttgga ccctgcccag caccctcaga cagggtccct    19260

gctgcactcg ccccaggtgg cacttggggc taggctccgt ggaaaagcag attccacaat    19320

ggggccgtgg tttcccaggc caggtagaaa ggcagtgctt gctgagggga cttgcagaat    19380

ggctgcctga gaggctcagg ggttgatggg ctcttccttc tgactcctga atctccacca    19440

gagccctgca cacctcagaa aggctagagc tccagcatgc agactgcaag tgttgtgggc    19500

aggcctggtg aggcagctcg gggtggtggg aagagctaga ccccagctct gccatttgct    19560

ggctatttca agttccctct accctctcag tttcagtttc agtttcttta tctgaaaaat    19620

gggaatagta tctttttttt tttgagatgg agtcttgctc tgtcacccag ggtggagtgc    19680

agtggcgcta tctcggctca ctgaaacctt cgcctgccgg gttcaagcga ttctcctgcc    19740

tcagcctccc aagtagctgg gattacaggc acacaccacc atgcccagct aatttttgtg    19800

tttttagtag agatggggtt tcatcatgtt ggtcaggctg gtctccaact cctgacctgg    19860

tgatccaccc cccttggcct cccaaagtgc tgggattaca gacgtgagcc accatgccca    19920

gtcatgtcta cttttcatgg tgtaatcatt aagataatgt tcataaacag ggtaccatcg    19980

tgtctaagac aaaatacaca gtcaatatgt ggcatttctt tttttttttt tttttttttt    20040

tttgagacgg atcctcgctc tgtctcccag gctatagtgc agtggtgtga tctcagctca    20100

ctgcaagctc cgcctcccgg gttcatgcca ttctcctgcc tcaacctccc aactagctgg    20160

gactacaggc gcctgccacc acgcccagct aattttttgt attttttagt agagacgggg    20220

tttcaccatg ttagccagga tggtctcgat ctcctgacct cgtgatccac ccacctcggc    20280

ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc tgaccaatat gtggcatttc    20340

tatttttctt attatttcta tttggagaat gaatggacag gatggtctta ctctcctgga    20400

agtggattgt tgagcctttt gtgaacaaag gtgatgctta cagctccgta attggtttaa    20460

aatgggtaag agccttgtgc tgaaaaccct gtgatcctca tcttgaatcc caagaaatgt    20520

tgttatttac ataaaaccaa aagtctgtgg ggcattcaaa agttgaaggg cctttgagaa    20580

ctctgatgat gttttcgtta ttgtgagatg gaagccaagc ttgtggctcc agccaaaaaa    20640

tttccaggtt ttgtagtcgg tgtggaggtc agaacaggca gcggtcacca tgtgtggcat    20700

gggttctagg acacacgacc cctggaaagt gcatttctcc ttctgttctt ccggaggcag    20760

ccagcaccct gcagatgagg gaagaagtca ttgaggattc caggagccac actcacaggc    20820

tggaaatgtc catggcagtc aagaaagaaa gattctgcca gggttcaggc ccttggcatc    20880

ctcaggtact ggaaagcact ggaaagcagg agaaatgaag gcaggaggca gccagcactg    20940

cactgagccc agacctccca ggtctcaggg gctgatggcg gacactctct ctgcaccgcc    21000

ctcctgccct agccagcccc ctgagtcagc ttctaatggt ctgtctcaca acttgcaggg    21060

aggcggcact atacacacat gctgaggcca ggtgcggtgg ctcatgcctg taatcccaga    21120

actttgggag gccgaagcag gcagaacacc tgatgtcagg agttcaacac cagcctggcc    21180

aacatggtga aaccccatct ctactaaaaa tacaaaaaat tagtgggaca tggtggcggg    21240

tgccattaat cccagctaat ggggaggctg acgcatgaga ggtgcttgaa cctgggaggc    21300

agaggttacg gtgagctgaa attgcgccac tgcagtctag cctggatgac aagagtgaaa    21360

ctccatctca aaaaaaaaaa ttcaattaaa ataaataaaa aaataaacac ctgctgagac    21420

ctcttcctaa gaaattcttt ggacttggag cacaggttgc cttgttctgg gcgtgcccag    21480

ctcagagagc tctagaagaa agttcaagaa ggcaaagagg agaatccagc tagccaaggt    21540

tggggaggtt ggaggaagag tgaacgcccc tgccggaggc cccccggtcc tcaccccctt    21600

ctgagtctca gcatctgcat gggctgtgag ccattgtttt gtgactgaca aatcagatga    21660

gggctgctta tttttcaaat gatcacgtca agttctctga tcacagccat agctacaagg    21720

caagcagagt ggggaagaca cccgtcaccc ttgtgcagac acttgtttta ccaacacttg    21780

gcgtgcaggg caaggcacca gcttctgaac ccaggtcacc tacaatctct tttttcctag    21840

gctgcctcgg cccgttgcag cctgaccttg ccctgccccg gcactcccac agcgggcagg    21900

attggaaagg gcagtgtctg gcacgttggc atgaaagcca gccaggaggg ttgggcaagg    21960

gctccagggc ccgtgaggaa ggagtggaga ccacaccatg cagtgccctg cccctgtttt    22020

gatttggtca tcattgtctg tgttcaatcc taagcttgtc gagaactggg ccggcatggc    22080

tattgaagtt ctgtggaaca gaagttggtc tcttacaggg gtgtggctga aacagcaaag    22140

gactggaagg cgtattagtc atctgtgctg tgtaataaat gactcccaaa tgtaactgct    22200

taaaacaaca aatgtgacca tcccacagat tttgagggtc aggaatcagg gagcggctcc    22260

gctgggtggt tctggctcag tgtccttcct gaggctgcag tcggctgggc tgcaacatct    22320

gcgggccagg ccaggctgga ggacccacat ccagaggcct cgcaagtggc tgcggcagga    22380

ggcctcagct ccgggccacg ggagctcccc acggctgctc ctctgttgcc cctatgtgac    22440

tgagcagcag ccacggcaca gcaggaagct cagtgccttt ggtgacctgg tctctgtaat    22500

tgcaccgtct cttctgccct tttttctgtt ggctagaaac gagtcactaa aatccagccc    22560

gttcacacag ggagaggaat taggctccac cttttgaagg tggtatcaaa gagtttgtgt    22620

atgtgttata aaccacaaca cctgacttct aatgccaact cctctttaac ttctgtgtaa    22680

ccttgggcaa attgctctaa atctctcagc ctcagtttct tcttccataa aatgagagag    22740

ctgatcctat ctctaatacc cttcctctca gccctcacac cctcacacct tcattcattc    22800

tgggtattta tttactaaac atttactcag ctctctgcta gaatgcctgg ggagtttcaa    22860

aaagactgat gcctggtttt aagtctcccc tagtgatgct actgtgcggg cagggttgag    22920

agtcctcctt ctggagtcat aatctgaaaa tgtgatttgc acgcaaatca cctgggggtc    22980

ttgttacaat gaagattttg atactggagg tctcgggtgc ggcctgaaat ttggcatttc    23040

taacgagctc ctgggtaatg cagtgcatcc cagggaccac tctttgaact cctcagagcc    23100

agtttctaga tgctggaaga aaggcgcaga aatataaaga tataaaaata taaagatgat    23160

tcccaccctc atggaacaag gaatccagtt ggagacggaa aacatgtagc cagcaccatc    23220

agggtctgac cgcctgccca ggatgtggtc caggcaccag gactgagtcg gagggggtga    23280

agaatccccc agtgagcacg gtctcgccgg accctgtgat ttccccacca ccagcatcat    23340

cccctgtccc ctcaggtcca cagcaggaca cagcatcaat ccagatcctt ctgtgatctt    23400

tggaagtctt ccacaaatta ggttgttttg ctgaacggta gttatttcca cagggaaaga    23460

aaagaattag caaatctatc acttgtattt gttcagtcct gtagactatt ccccaggtta    23520

aacatttgtt tagtgagcct gcttttattg gcaccacaaa caaattaaag tgtattttcc    23580

gaacttatct tcagggtgta aaattccagg cttatggaaa ttctagtaaa atagctttta    23640

aaaaaccatc atcttagctt ttattctttc taccttatgg tttttctgtc ttctccaaag    23700

ggccctcttc ccatcccctg agcaggaagg aagtgaagta ttcccacaac cttagacctt    23760

ggtcccctgc cccaccctgg ttattctctg tgtggcctgc ctgcaatcct gtccacctcc    23820

ctgcccagtc aggctccctg ggcaccgtcc agaggcccca gctcccagac catctccact    23880

cagtgtcctg ccctccttgt gtctcagtat aaccaaggca atgtcaggat cctcctcact    23940

tcatatctca gcctctgaaa cagactccta ggtgaactct gggctcccag gttctcttct    24000

tgctaacctt tacacaccat ttgcagatta atagtcctga aatatttcct gcatcctgtc    24060

actgactcca aacatctcat gtctcctggt gtcgtaaaga agcttcttta actcaaatgc    24120

gtaccacctg gggttctgct aaaaatgtag attctgaccc actgggcctc gggtaggggc    24180

ctgagatttt ccagctctga ggagctccca ggcgatgctc ccctctcagt gcaaagctca    24240

agcagcaaga ttctgcagga tgaggccaca ctacccatcc gtcattttcc acaggggaaa    24300

gtgtcttctt agccagactc atcacgtcat ccagatagcc aaggctcaga cgtcaccaaa    24360

gcctgtgctg ggctggctag accctccatt agcaatttcc ccacttttaa ctgtgtttaa    24420

agaaatctga gttgtatgtt cttatgaccc agattgaact ctggattctc ctgaagcctt    24480

ctctaactca gtgattcttt cacccctttt tggatccctg cacaagttag ctcttcattg    24540

cacactgcct tgcgttgtta ttaatatttt gggttttctt cttttacatg tttctgtctt    24600

tccagctagc tgctgaagcc cctgggactg cagctcacac tcctttcact tcttttatat    24660

ttctttcagc actgagatgg tgctgtgcct ttagtaagca cttaataaat atcttttctt    24720

taaatgaccc aaagcaaaat tcctgtactt aatgaaaaat tagtttgaga aataaaggga    24780

ataaaaatga aattgaaaca gaatgacccc cattttacag ccctccctga atagcatata    24840

aaggtctgct tcatgccaac atcctcactg agtcctcggg gccaggacct gtatgccttt    24900

ggaggcctgg catggtgtct ggccccataa acatttgaaa aatgcttgat tcgtgagttc    24960

attaatcgtt ctcctctcac cggagataca accatccgaa cttagccagc acatacagat    25020

caatagcagc aagaacaaga ccaagaaagt gggtaatttc aaataaggtc ttggaaagac    25080

agaatcaaag tgcatatcta aaaataggtg gggtggaggt tggagctgag ggcagagaga    25140

agagcaggaa aaaaaaaaag aaggttgtca aagccagggt tcagctgcta gagatcaaga    25200

ccagccatag agcagaggtg ccttctttct tcatcaccct tgttgaatcc aattctcaag    25260

gagctaaaac catgactgtc acacaacgta aactgactgt gcatcaggga ctcattcagc    25320

tccttaatga gggatccctt gaggtggcct tgctgattcc gggagcttct gaggaatgga    25380

ataagttagg ataacaaaac tgcttaaggt cccacagagc agtgaagtct tacaatcttt    25440

gtggttgtct tttttatcag gctaaaatct gcaagctaac atgtaaccct accgtgactg    25500

ggctttggcc aaatagtgca tagcagagtg aagctcaggt acacgcccct ggagatgaca    25560

tcatctcagg caggcctgag tccctggaaa gctagtttcc ttccacatga ccttatttcc    25620

tagtgttcga tggctttttg tatcagcatc aagctttaac ccagggctac ccagagtaaa    25680

gggggcaaat tctgtgcaca gcagtgcaga agaaggtgcc agctcacttc ttccctggta    25740

gctaggaaga aaagagaaca ccatgcctgt gatcaggagg cgccacagac agactggtca    25800

cccatgcagc cttggcttgc cctctgagta tgcctaccac ccttctgctc caattctcaa    25860

caagccagaa tatttctgtg ggatctgtgt tacctcatcc tggttagaac tgctggggac    25920

aaacctcccc ataatgaaca gaaaatgcta catccctggt ttgcaaaact tcaacagtca    25980

aaaggatgca tgtacaatta tttttctata gggatgcata atccaaaaaa caaaaaaagg    26040

cttgaagacc tatgagctaa accattccat cttaaatgtt gaagtatgtc tgggtcagct    26100

ctgatttagt agatctaggg ggctccaggt tcttcatttc caacaggctc tctggcgatg    26160

ctgatgcagc tggtatgtgg accccacttt gagaagagac agtttccact aaagtgagaa    26220

caatgacggc gccttcccca ggtggtggct gtgaaaatca ggtgatatta tccctgtgca    26280

gcactcagct ccatcccagg gcctgggact gaggcattct tgggacagtg ggcgcatgtc    26340

ctatgctcaa taacacatct ctctatgatc tctccacgcg tcctgttctg tgtgcatgag    26400

ctgttttcta cccctgtggc tggggccctc cagctccgca aagccggatt tgacaggtct    26460

tagactcact aatcttgagg gttttccatc ttttgtttct gtgaagtcac tgctctcaat    26520

aacattgtta cctgaagaga aatttatctt ggtgggttct tactttcctt ttaaaaaata    26580

tccacatatg aagctctcaa acaagcagaa atccaccgtc tagtttttcc caatagactg    26640

tgttattgga agctttgagg gataagggga aaagaaattg gtttatgaag taaaattgaa    26700

gcaattaaag gatcaaaatc accttacatt ttcctacaaa gacacactct gtcaggcatg    26760

gacagccccc tgctctttca agttttatag ccaccccgtc ttggcagaaa aattaggaag    26820

tcacttgttg tgcacaagac tgttgtaaac ctctttgata ataaaaaaag gataaaaaga    26880

caagtaggag acccgtaaac acgaacttta aaggcctgga gaacagcagg cttccccttc    26940

ttctgctcct gctcttagcc cacaagccct caaaccattt tctacagcac atttgctgca    27000

gcctcaggga gaacatgaac tattgaagta aaaaaaattc tagcctttga tattcttcat    27060

gtttttttcc tgtttttccc tgtgaaatat gaacctgcaa ctgattatcc cagggacttg    27120

atctcaaaaa cataatttgg ccgggtgcag tggctcatgc ctgtaatctg agcactttgg    27180

gaggccaagg caggtggatc agttgagggc aggagttcaa aaccagccta accaacatga    27240

caaaactccg tctctactaa aaatacaaaa attagcctgg catggtagcg ggtgcctgta    27300

atcccagcta cttgggaggc tgaggcagaa gaattgcttg aacctgggaa gcagaggttt    27360

cagtgggcca agactgtgcc acagcactcc agcctgggca acagagtgag actccatctc    27420

aaacaaacaa acaaacccat gcacaattgg ctggtctttg ggacaaaccc cagtaaagag    27480

ggtccctctc tgtctccctt tcacttcatc atgttagtgg agttgtttgt cctactcagc    27540

agtttagcca agaatagtgg tccccaggca atcaatcctc cctccactgt gctcccttcc    27600

agggctggca cttggcctct gccagcaggc catgtgggct cagtagcttg ggaagccctt    27660

ctctacaggc agagccaaca cagctgaagc tcattttctc agaaccccta tagccaaaca    27720

cagtagtgtt cctgaagaca gtagggtttc cttactattt gaatgcactt gggcaccgta    27780

gaactctctg atgactattg tccagacaga agatgacctc ttcctcatag tcttcaggtt    27840

gaaagagcac agggtatggc tgagaccaca ggctctgacc ccacataact gcaccggggc    27900

ccgcgagatg aggcataggc cttcctgtgc cctgtgagga gtcactccag aggagctctg    27960

cctgcggctg gcctccaatg ccactgcatt tcttaaggct ttgaagggac ttaatgccag    28020

tctcagcata gtaaatctaa acccttcacc caaagttcat gtgttaattg caaagatcat    28080

ctgactttaa aatattgata atagaaatga caaagacgga acttgagtag gcaacaacat    28140

gcaaggcaga caggtctttg cattcttgaa atttgatact taagatgaca ggggcaataa    28200

aagaccagga ggagaggctt gcttcaaagt tggtcttatc aaaacacctt gaggtgttaa    28260

tgactttctt aacagaactc caaggctata aactgcttta gatccaagga tatggtgata    28320

ttgaatgttt taattgtggt attaacagcc ccagttgtaa aagggaaggt gtcactcaaa    28380

gatgagggac aaggcctgaa ttttataacc gaatttaatt ggcactgatt tgacgttgat    28440

agtacctggt ttttccagtt ttcaggaaat atttctttgc ctggggggag aggggggagc    28500

acagaaggga aaggtggagg gagagtacat gatgcaggag gggaggagag ggtgctgcac    28560

atcaaaaggc ccatcttgaa tttcctgtga tgtgctaaaa ccccagcccc ccaccaccac    28620

atcaatgcac agagcagtca cacctctcct acatcaaacc ccaattacta cacacccagg    28680

gaaggtgccc agctctccca ctgcagcagt cacccaaatg agaaggaagg aggcatacag    28740

acacccaaag gtaagaggaa aagacccaaa gccagtagag cccaggagga gaaaatcctg    28800

atggggtaaa aaccttctaa ggatcttcct gtctgtaatg tttttctctc cccaaaagac    28860

ctgtatctgg gaacaactgg gtcatttatt atcttttttt ttttttttga gacgaaatct    28920

cgctctgtct cccaggttgg agtgcagtgg cgtgacctcg gcctcccggg ttcatgccat    28980

tctcctgcct cagcctcccg agtagctggg actacaggca cccaccacca cgcccagcta    29040

attttgtttt tgtattttta gtagagatgg ggtttcacca tgttagccag gatggtctcg    29100

atctcctgac ctcatgatcc gcctgcctcg gcctcccaaa gtgctgggat tacagtcgtg    29160

agccaccgcg cctggcccat ttgttgtcat taaaagatat aatcatgaca ctttggacac    29220

tcaaaaaata aataccagta cccttcacac acacacacag acacacacat gcttgcgtgc    29280

acacacactt ttctaagtgg gtggcatagt taaaaaatgt ttggaggaat attaaagtaa    29340

gtttttagaa tgttcatgta aaagaggcag gttgtgctat tgaagagagt cttagatcat    29400

taaaaaaaat ttaaatgtta agctgaactt tataggattt aattagaatg aatgaactgt    29460

tccttattcc agacgtgctg ttattaagta tgtttttgtc atgctacaca gtttgtggaa    29520

ttatttccaa acatttgggg tctgtggctc tctggaaggt cttctgatta ggaacctcag    29580

ctctctgggt agaagcaagc caagggctgc tgcctgctgt cacttagtga gcactgagtg    29640

tggcgtaacg gagagtgtgg attccagcac tgggatgctc tcctgtggac acgccttcag    29700

cacttcttct ttctggaatt ggagtgctat ttgctgctcc atttgctcag agaaacctag    29760

ttctttaaac agctgccctt tgttgttaaa agattatcct catttcagtc actggtgact    29820

gtggtttggt tgggcttttg gagtttgttg gggttttttt cccccaaagt acctgatttc    29880

ctcttagagt agggactttt atttctcata ttttgggttt cctcttcagt ttagggaaag    29940

atgaacagct ccatgacctg atcccttttc gtcacagttc cctgttagtg ggactgcttt    30000

ggagccgtgg catcatgtgg cagagactga gacttgaact ggagtccaga tgacctggca    30060

ggggcttctg gctgtagcac aggtcaccgg tggacctcag aaaagtcctg gatctctcag    30120

agtctcagtt tccccaggag taaataaaaa acgtgcccca tctatacaag cctggatgtt    30180

tttaattaga gcatttcagg aggtgggagg gatctgaaag actatcttct gtgctgccca    30240

gtggggtagc cacagccata cgtgtctgtt taaatttaaa ttaagtagaa ttcattaaca    30300

tgagaaactc agtgcttcag gggcagtggc cacagttcag gctcagcagc cacagaggcc    30360

atagtcctgg acagtgccag gctcagctgc ctcagctgat ggttgaggaa aatggtccaa    30420

gaagtgagtc caggattggc ccatgctcca gccagagccg accctactgg ctcctcagtc    30480

tatggtcatc tgcttctgag tgtgtgggtg tctctccagc cagctcacac tttcctcttt    30540

ctgccttatc ttcccacaag aaggcagagt ctacagatgg aagggtccct ctttgcaggt    30600

tgcaggcccc aggccaggca gtcctgtgat acccatagcc tgggaattgc ccagaattgg    30660

ccgcaacatt ctgcagtgct ctcaggttca ttcttctgtt gaaagggctc ctggctcttg    30720

cagatcatgg agttttataa aacggagtct ctaaaacccc tcttgtaatt gtcttctgtc    30780

ttgactatat tgctgtccac acctgactac tgtgcaggtg ccatcatcct gtaattttac    30840

cagacgaaac cattggggta cattgggtaa cggggacatg ggatctctct gtattatctc    30900

ttacaagtgc acgtgaatcc actttcaaat agaaagctca atttttttaa atgtccttgt    30960

gcagttttta caattcgaat cttcttgaat tttagaacgt cggctctagg catcctagaa    31020

acagattttg aagggctctt gaaagcaaat tgaattcttt tctcatagtt gctatgaaca    31080

gtttaacagt gtgtagtgcg tgatcatttt tgcttacgta gcccttttac gttggccaca    31140

gagtttcaga taagaataca tcatgtaaaa cttcagatgt attttcccaa aactggaatg    31200

tgtctctgtt gttggactcg tgcacacagt caagtggttg aagctagggg tgtacagcag    31260

tttgcggcct ctgcagggct ggactgggga cttacaagtg acagtgagtg accttcagtg    31320

acgcagagcc accagatttt gttcagttca attgatcgct ggtgcagatg tccctggcaa    31380

gggtaagaca agtgcacagt gagccctcct gtccttggca tctctgtagc tctctcctta    31440

tcctagaaca acactgggat tgtctgcaga tctcttgttt gtagatcttt gacaaaacca    31500

ttgaagagtg aggatctttg gatttgtgct tttaattcag catcactctg ctcagtctct    31560

tggacagaat ggtactgcgg ttggttttga aaagggtgtg tgtgcgatgg tgtcatgcca    31620

ggaagagttg gccttggcat gggaggccct tgaattgcat tcctttctct cttttttttt    31680

tttttttttt ttttttttga gacagagtct cgctctgtcg cccaggctgg agggcagtgg    31740

agcgatctcg gctctctgca agctccgcct cctgggttca cgccattctc ctgcctcagc    31800

ctcccgagta gctgggacta caggcgcccg ccaccacgcc cggctaattt tttttgtatt    31860

tttagtagag acagggtttc actgtgttcg ccaggatggt ctcgatctcc tgacctcatg    31920

atccaccagc ctcggcctcc caaagtgctg ggattacagg cgtgagccac cgcgtctggc    31980

cgattgtgtt cctttttcat cacttattgg ctatttgagc tttgacaatt atcccaaact    32040

ctttaatcct ccatttcatt acctgtaaga cagggacaac acaacctacc tatttcataa    32100

gattttcctg cgaatgaacg ttggttcaca tgtgtgaaag gctgtgagag cgtccgagca    32160

tctcagcgca atctgcaatg cgccatctgc catcagggaa ccctaaggaa aggctgagag    32220

gctgcctaga cagggcgcca catgctaccc taccagagtt cacagtctca cttggacatc    32280

tttgtggatt tccttctgtg atttacacag ggaaaaaagt ctctccagga ttttatccaa    32340

actgttagat tctgggagag gtgttgggag aaacagctca tgacttatct tacagctgcg    32400

cttcccctct ttgatttccc tgaacacagc tagagttttt cttacaaata ttaacttgga    32460

aaaatgagag ttggcccagc tatgcttgct atggactcac tgcttccatt catttccagc    32520

acaggggcca ttagtgtgaa gcaagggtct ccctccccag gctcaggtca cgagagagca    32580

gcagcaggtt aaaagaccca acacatgggc tgatcacttc tcacctcttc caggaagcct    32640

ccccaggctt ttccgcaccc acccaaggct gagctgagcc caaggcccct tgcatcagaa    32700

tgaatgtgtt ctgaccatag agtttcagaa aagaaaacgt aacaataaca ccatctgcca    32760

gtgagtgctt ttttaatgta aatgtctgtt tttgcagaac gtccataacc aaaagagcag    32820

ttcaaccttc agcatgtaaa tctgatgtag gcagcgggaa ccaggagctc tacctccctc    32880

tgaagagggc ctggctgtga gcagggcagg gcagccaagg agggtggctg gtcccagaga    32940

agctgtgctc caatgctggc tcctccctgc ctgcctccac tggtggtggg tgtgccagat    33000

gcccttgagt gagtgagggg aggtcagcct agactggtgg gtcctggggg cagaggcctc    33060

caggctgcag tgtgtctccc cctcttaatt atttaggagg gaaaggactg gcaactgttc    33120

cctttcctga atctggttct ttaccctttc attaaaaatt atggtcagtc ttctttttct    33180

gtctgggcct ccaaaaccca gtcagggcca ggcccagagg ctctgcagcg ggggccactc    33240

tgcagggtct gctccagtgc tggtcgggag gtggccgagc atttctgcat ccatgcgtgc    33300

tcacccacca ctcatttata cgcctggcct ctgacccaac agttctacca ctgggactct    33360

attgtaagga aataattaga agtctatcca ctgtgtcttt tatgtacgtt gtggcgttca    33420

ttataatagt gaaaaacttt gaaataaagt cgaatgtcca gccttagggg atactcttgg    33480

tacatccaca tggtggaata ctatatagcc atgttcctga agaatatttc aaatgaagag    33540

gctcattaaa tcattaagca aacaggatac aaaactcaat atacgatatg actccttatg    33600

atatatctat atatctatac atagtaaaag gaaatatatc aaaatctcaa taatgtttcc    33660

atatggtagg accagcagtg atttttagtt ttcttcttta tacttttaca tgtttgaaaa    33720

cttctttaca attagtagtg tttttacaat caggaaaata tgaaaaaaaa tgtaaaaacc    33780

tatcagtgac agagccagcg tggtggaagt tgttgtccac ttttctgctg gctgacgggg    33840

cagcagagac aggtgtgcac cctgccctgg ctcctcatgc ccccaccttc caaacattcc    33900

agattatact tattctttgc ctgatctgag aaattctggt atcctgtttt tggggggagc    33960

accacaggtg aacccataga ggcattcatc agcaagagcg tcttgagaac atagaccacc    34020

ctccactaaa cattctgagg cagtgagcac tttttttgtt cagacaatct cctaggaaag    34080

tgtcaaacca gctcctaaaa acagagttaa aaccttgggg gatcctcagt ttgaggctct    34140

tgtggacaaa tagagaaact gcagccccgg ggagaactgg tggttgccag gacacccagg    34200

ccagactgag ccagggctgg gatccccacc ccgctcctct tagcaccctg tactatcagt    34260

ggacccagcc acagggtgtg cagggtggac aggccagcac ccagcttccc tctttggagg    34320

gcactgcttt ctcagagcca ccgtggccac gttagtgcat catgacattg actgagtggc    34380

tgcagactag catgttttaa atggaaaggg accatgtggt atagcactgt gtaacatggt    34440

ctaggatgga gaatgttgtg tagggcaagt gttggtttca cttggatatg tgtgtgcttg    34500

tatgtatgtg cgagtatttt tagagaaggc ttgagtttct tgagagacct gtggaaaagc    34560

tggtgtctca gaagacatat ctttctcatt ttcagccagc actcctcatc aagctcctga    34620

atcccctgta gacatttggc tctcatacgc tggggaaagg cgaaatctcc actgcccacg    34680

gccccagcag ccattcaccg ggcatccaga gctgagtccc agggcgcatg ccacagccgg    34740

cactggcctg gctggagccc caagggtgtg tgaggcccca gctcccctca gccccatgac    34800

tgctgtgaga accaggtccc ttggaaacct gacaacctga gtcatcttgg cacaggtttt    34860

aagcatcaca gagaaacaaa gcattgaaag atgcaatatt ctgctcatga aagacccagg    34920

aggacctgaa ctgggttgga tcagggagaa ccccaagtca cagcccagcg tcccctgcat    34980

tacagacact ggggagctct gatttctctg ctgcatgtct tgctctttgg gaaaacaaat    35040

ctccaacacc aggtcatctc tccatccacc aggctgtaag agttcccaga tcgcagacca    35100

cagggcttca taggccatca tcagcccctc tgcacaaact tggccttgca atggccccat    35160

cagctttact gaagccttgg ctttcctcgg gccacctgcc accagcatgc cccatataca    35220

ctccattagt cacgattcta gctgttccag agtcaggaat tcacgggaag ccacagagaa    35280

ctggtgttga tacacgtttt tctggctcta acccactttc taagcatgat tttgggagca    35340

cagtgtcccg ttcttcatgg gtgccaattc caatggcctc agccactagc catggaggcc    35400

acttcttgag gacttgcagg gaagtggcat tccatgatgt ggatgtggct cccaggttct    35460

ctcatgaact gtgttgtcac ctgccccaaa cttggtgcct tttcccagcc agccatgagc    35520

ctggagagcc cactatctct ggctgacact tccaagtggc tgtaacattc aacagaattc    35580

attcacatcc agtcacaaca ttcaacaaaa tcagaagcct tgcgcttgag ctttaggtct    35640

cctgggccag atatctaggg gtgttccaac agaagtcacc tgcaaaggcc tgagagctgg    35700

acttgggctt cttaactaca gagactgact cctggctctg ccattgctaa gggagctagc    35760

tgtcccgagc aatagggcgg ccatggggtg ccctcccacc gtccttctgc cctctctact    35820

gtgcgtcctg ggtccagggt cttgccatgc ccccctgttc tgccccctgc ctgaacaaac    35880

gcacccttgt gagccttctg cctcagctcc tggaaggcac tgccctgggg ttttttttgt    35940

tttttgtttt ttgttttttt tttcctgctg aaggaataac tatttcatgg ttattaatga    36000

aagtgatagc aattccctgt gtatttatct tagattatgt ggtcgttacg agctgaagta    36060

cctcaagcag ccagtctgcg gttgatttga aaacaggcga gtctcaacag tgagcttaag    36120

gaaaggtgtc aggtataaat cttgtcttca aacagccagg gtgcattcca gacttcagag    36180

acacttcttt gtataaaggc cctttttttc tctcccgcct ttctttctcc tgggcctgga    36240

ggaggatgaa agtgcagggg tgtgtgcgtt cgtttagtct gataatgagg gtgaggctca    36300

cgggcatggt aatttggcag ctttggcact tcctgtaaca gttttgattt ttttttaatc    36360

caaagggctg cttaaagaca aacatttttt gttaaactgc tggtagttca ttttctgcag    36420

gaactgtgca attaatcttg tttatattaa agagacaggt tgcttttgtc agctttcctg    36480

cgctataatt aataaagatc aaaaacgtta caaaaacata atatttagct taatgcagat    36540

gaggctaggc aacagctgca tcaattagag gagcaaaagg ggaaagaaat accctttgct    36600

ttggaataac tcggatgcat taaaaaacat ggattgtgag gcttctcacc tccactagcc    36660

tcgcctggta ggcccggtga aggatggggt ttggacatca aatagtttgt aaggccgcat    36720

caattatgtt gtaaatgcag ttggaggcac ctactcttaa cccacgttta tccaggtgtg    36780

tggctgtgga tcagaagcat ggagcctgag gatctctgca gtggaggagg gtgaagaaat    36840

cagatggcag gcagaacctg atagaaccat ccagccccct ggggggcctc catgagcccg    36900

gggccacttg atttatagcc ctctatttga aggactgtca ttagaaacca aaacagtgat    36960

tagatatgcc caaacagatg tcattacctg cccccgactt cctaaaccag tgactaagac    37020

ctttggcttc cacatgagag ttcaaacagg gtcatctctg cccataaaca agaggcgttg    37080

ctgtttccag gctttcatct gtctcacgaa gcgaaggtga acagccacct gggagcccac    37140

cagaaatttg gtggagatgc agtgtgaggg ctggaactgg ttgtcagtgg cacccaggcc    37200

agttacctca cttagatttc aaggaattga ggcctgggga aagtgtagaa ctgcaagtcc    37260

cacagttaca cagcctttgc cttggctggg cgtggcggct cacgcctgta attccagcac    37320

tttgggaggc cgaggcaggc agatcacctg aggtcgggag tttgacacca gtctgaccaa    37380

cgtggagaaa ccccgtctct actaaaaata caaaaaatta gcggggcgtg gtggtaggtg    37440

cctgtaatcc cagctactcg ggaggctgag gcaggagaac cgcttgaacc tgggaggtgg    37500

aggttgcggt gtgctgagat cgtgccattg cactgtagcc tgggcaacaa gaacaaaaac    37560

tctgtctcaa aaaaaacaaa aaaaaaaaga gagctttcgc ctttcctgct gagcttcaaa    37620

acttgggatc ctaatcgtaa aagtccagga caaggaggga tatgcaaaat gaatcataac    37680

ccaaatattt tcagcaaatt ctggtggcat aagaaggtgg ctgagcagat ggaaggaact    37740

gcccataatc aagcatctat gagggaaatt tcactgtcag tcaaccatct aaccagaaaa    37800

gcacccaagg gagccttgtg ccttgccaga tttcaatgcc atgtgtagtt tcttggctac    37860

ccagaatgga ctgataaaca tcagaacctg ctgacgtgag agactcttgg tgcagtgcta    37920

gtggaggaca tggagggatt tgagtggcat caggaatgcc agtattctaa accaaatgga    37980

gttcctacct gaaaccaaac caaagtcatc tccaagtttt agaggacacc tctacaggca    38040

tcataacact ctcatgccct ttaacttcta ctcttcagaa tgtataaaaa gggtatctcc    38100

agccaggcac aaagatgttc attgcaactg tatttatgac agtgaaaatt gggaaccagc    38160

ctgaaggaca aatattaggg gattggttga tttaattatg gcttgttcat ttgatgggat    38220

actttcaatc cattaaaaag gctgttgtta agaataatta agacaatagg gaatgaaaca    38280

gtcaaaccac aagtagcccg aacagtgttt taatctaatt ttattttatt tattttattt    38340

ttttgagaca gagtcttgcc ctgttgccca ggctggagta cagtggcacc atctcggctc    38400

actgcaagct ccacctcctg ggttcccgcc attcttctgc ctcagcctcc cgagtagctg    38460

ggactacagg cgcctgccac catgcccggc taattttttg tatttttttt agtacagaca    38520

gtatttcgcc gtgttagcca ggatggtctc aatctcctga ccttgtggtc tgcccgcctc    38580

ggcctcccaa agtgctggga ttacaggcat gagccaccgc gccctacctc taattttatt    38640

ttatgttatt gtatttattt attttttgag acagagtctc actctgtcgc ccaggctata    38700

gtgcagtggt gtgatctcgg ctcactgcaa cctccgcctc ctgggctcaa gattgtcctg    38760

cttcagtctc ccaggtagct gggattacag gcaagtgcca ccacaccatg ttggccaggc    38820

aggtctcaaa cccctgacct caggtgatct gcccaccacg gcctcccaga gtgctaggat    38880

tacaggtgtg agccactgca cctggcctaa tttcatttta gaagatatat atgtctctac    38940

aaataaggga ctgaaagaaa atgccaaaac ccaaaattaa tgggttatga ttttatttct    39000

ttatattttt cttttatttt acaattcttc cataattgga aaataattat attaccttgc    39060

attcattagc acttactgtt gtaaatactt tatacacatc atctcattta atttatctca    39120

ttaatcctca cattctgacc taggttctat taatatcata attttactga tgagacaacc    39180

aaggcacaga catttagatt acttgcccaa agttgcatag ctagtaaatt aagcccaaat    39240

ttgaacccag gaaatcagac attagagtcc tgttcttata atcactaccc tttaatgcta    39300

ttattaaaat tagttgtgag cgcttccctc agggagatgt gccagtcact catagcctgg    39360

tgggagttcc tgtgtaagat tatcttcccg gccaggtctg gtggctcacg catgtaatcc    39420

cagcactttg ggaggctgag gcagacggat cacctgaggt caggagttca aggccagcct    39480

ggccaacgtg gtgaaatccc gtctcaatta aaaatacatg tatacaaaaa ttagccggcc    39540

atggtggcgg gcgcctgtaa tactagctac tcaggaggct gagacaggag aatcgcttga    39600

acctgggagg tggaggttgc agtgagccga gatcacgcca ttgcactcca gcctggtcaa    39660

tagagcgaga ctctgtctca gaaaaaaaaa aaaagattat cttcccagtg acagctgctt    39720

gaataaaggt cactgaggga atgtgacaga ggaaagcaga cagagacaca gaattcaggg    39780

accatacata ccaggcacag ggctgggtgg gatgagcgtt gactaagatg aaaagagcaa    39840

agcatgtggc tcacaatttt gccaaggaga gtgggtgggg agccttttcc aaggatagtt    39900

tcaggactgg tggccacata atgggataga gaccaccaca cctatccaaa gtttgcaggg    39960

cgagagaggg caggtaggct gcagaatgtc tgtgaaattc ctttaagtaa tgagctattc    40020

aaataataag catatacatt aagatgggaa aatggcagcc catatatctt ggggtatagg    40080

tcttgatgta tagctatctg cccacacacc acaatctgct gctggtctcc ggaacaggat    40140

ctccagttct aaagagaaaa tgatctagga cataacatgg aaatgccatc tatgctatct    40200

aggttgccat aactgcagga ttttataaga aggtggtgag ggaattggtg gataaggtgc    40260

gttacttttc ctcactgggt tatctgagag accatagcaa gaaatcatag aggggatagg    40320

cttatacaga gagaggggct cctttaattc tctttgtctg accctagaag acttatcatg    40380

cctttcagga gcaaccaaag aagttttagg atcttggtaa tctttagtgt ctcacttata    40440

atatgtagaa aaacattatt tcaaaggata tccatattct tgatccctct gacctgtctg    40500

gttcaacttc acttgaccct tgggcacaca aatggtgtta aagagcagag gaaaggctca    40560

aagcctcaga accattttct tctgcctaac tggcctctcc acctgccagt tttctggtgc    40620

ttctttattg tttccatcgc caccagccta ccttaggtcc ttgttcacat agctacctcc    40680

agtgtctcat cagtcacatc catccgacaa tgacagcacc aaattagtct tcctagaaaa    40740

tcatctggtt gtgtcctggt ctaccaaaaa caactataga actggacaag tatgggaggt    40800

aactgcaact gtcatcaggt attggacaac aaacagcaca ggaccgtgag ccttaagaaa    40860

agtaaaatat acccattcac cctggcttcc tagccagagg gaatttgtag actgtagtga    40920

ggccaagcag agaggatgtc ttaatgagat gaagaggcag agtttagaga taaagtatct    40980

acaatttgtg gaacaggata ccagagaaga gagtactgca cagaagaaag tcccagaaat    41040

cagcatgaag tttaccggtg ggtcttggcc aagactcggc acaagctagc agacaacaga    41100

gaacacctgt tgtggacagc agagctcaga tgcctcacag ggataagcaa ttctgaagca    41160

tcggcttagc cagaatgcag aaagctcagc caccactttg agctttcaat agagactcca    41220

agagcacaga tggattattt gtaacacaaa ggataaatgc ttgaggggat ggatacccca    41280

cttttcatga tgtggttatt acgcattgca tgcctatatc aaaatatctc atgtaccaca    41340

taaatatgta cacctactac atacacacaa aaattaaacg ttttttaaaa agacctcaga    41400

aagtctatac ttcaggaatc aggataatgc cttggaacta aaagcagaaa cataaataga    41460

ccaaccctaa taaagaaaaa agtcaagact gacaggtttg ggaggatctt ccagtaattt    41520

gacacttgcc cagagtaaaa ctcagtgcta tttaaagtag atttcacata tcattacgat    41580

gtctggcata tgataaaaca ttaccacaca tacgaagaaa taggaaaatg tgacccataa    41640

tccaaaaata atgaattcaa tagaaacaga ccccaggata atccggatgt tggaattaac    41700

taagacttta gaataactca tattaatatg ttcaaggatt taaagaaaaa gttggattta    41760

atgagtgaac agatggagaa tctcagcaga gcaagtgaaa gtatttttta aaaaggaaat    41820

cctagaagtg aaaagtatat ctgaaatgaa aaattcacca gaagggcttt acaatgtatt    41880

ggaggctgta gaagagagaa gcagtgaatt aaagtcagat caattgaacc ttcctaatct    41940

gcataataga gtattttaaa aatttcatca tgtcctcatt attcagaaac cctcctctcc    42000

tatcttgtgt acttaaagga aacaaaatcc tgatatttaa agtattttgc aattagtcac    42060

caaactacct tctacccaat ctcccagtcc ccttcacatg aacccattat ttaaaccaaa    42120

tcaatcaaca agctgcccca gcacctgtac ctccccacct tggcccttcc acacatggtg    42180

ctcatacctg aaattctctc ccctctttca ggtccttgag atgatatcaa atgccaccat    42240

tttaaccttc ttcaatgtgc ctaactagca atgtgatttc tcccttttga ccttccgtca    42300

aacaaacaaa tgaaaaaaca aagcagtaac aagagaaaaa taaaacatgc ttttgcttct    42360

ttgtgaaaat attcttggtc ctgcctgcat ggtcttttgt cttggatcta agccctctta    42420

ttagactgta agagtgtcaa gggaaagtct atgtcttact catcattgta caccattcaa    42480

tacctcaaga gaccttggga agatcataat gtctgccgaa ttaattggaa tataactgtg    42540

atttgagaag atagtccata acacaggcat tggttctgat atagtgttgc caagagcttt    42600

cactgcatat catagatcta agagaacctc gtggactcgc agaaatggaa gaacctttag    42660

aatgatctag tataagaccc tcattttaca gttaaagaaa ttgcaggctt tagtgaagtg    42720

tcttacccaa ggccccatcc tgatccagtg cccttccctg taaaccatat cacctttatc    42780

cctgtgccaa tatctataca ggattgtgta taggatttgg aacaataaat ttaaacacac    42840

atctaaattt tgacaagaat aagcccctcc catcaagctg tgctttatat taaattcatt    42900

tcagtttttc tggagttcac tacgtgctag tacaataatc acataagaca tcctggcctt    42960

tctggtcgaa ttcctgtatg accttggaca caatgctgcc cagctaacag aaataactga    43020

tggttcagtt ctttgtgacc atttgctaag ttcagagttt cttcaatacc tgtacagtag    43080

tgtggtcatt ggaattacat ggcattggcc tggtcaaatg cagaagaccg atattgagac    43140

ccttcaagac acagctgcta taggggaaac tgagctcata taaccaggag aaggggaaag    43200

atgggtttct gaaaaaaggc ttcaagctac atagaatcct ctcaggatgc tgagaaactc    43260

ccagggcagg tagttatcag cctggtgagc aagtgcaaga aataactgga ttatgagagg    43320

catgcctcac aagtggcccc ttcaatatag aagcatcagt gctcccagat gctggacaat    43380

ggatggcaga caaaggctgc agctgagtcc cccaactggc agctgccctt gggtgaagaa    43440

gcctgcctca tgcaaggtca caccccttcc tgggggcctg gttaatgtgg atgtgtgaag    43500

gcctgggtcc cttgctccag ttcaggacag ctctgtaggg ccatccctgt gctgagaatg    43560

tattgcccct tctgccaaca gtgttgattc caaagccttc tgataaatat cttgcactta    43620

catctccagc ccaaggtctg attcccggag aactggactc atgaagggag caagggcagg    43680

gatgtggaga aggctgaggg cagctccaac agagcagagg ggacagcata tggctgtgtg    43740

tcacgtccag aatgcagact tggagctttg tggtgttcag gatgaagtca cacactgtcc    43800

agctttcagc tacatcatgt cagaatatga acgaataaac aatctcttgt gcttccctgg    43860

ttgatctggc cttgtctggc tcatgtgctg ttaaacacca tcggccctta taaacagaaa    43920

tacaacatgc tctacataaa gacatcacat ctaaattagc cagaggcagt ggcatgcacc    43980

tgtactccca gctactcttg aggctgaggc gggaggatca ttcgagccca aaaatttgat    44040

gctgcagtga gctatgcttg actgagaccc gcctgtcaaa aaaagaaaaa aaagaaagaa    44100

agaaaaagaa aaggaatgga gggagggagg gaggagggag ggaggaagga agggagggag    44160

ggagggaggt agggagggaa ggaaagagaa aaaagacatg acatcttaga tggctgtcat    44220

ctgttctgcc ttgtagggct gaacatgtcc ctatgtgtgc tgcattcact cttcagccag    44280

caggcccctc ctggggtcat aagtgcccct ccccatggca ccatgcccag gccgcactca    44340

gtgaataaac catctgacaa ttgatttgtc cagtttgctg cacccaatct ccacagttcc    44400

ccctactccc atatacattt gttatttcaa aaacctcagg aaatgagggc attggcctcc    44460

atgagctcat agaatctttg atttggaagg gacatattac tcggaggtta ttttccagtc    44520

acatctgctt ctaaggcacc atgaagacct aacccatgat aaatcattgg ctacatacct    44580

catcatctta actgagtcac tctttctctt tggagtttga gaagaaataa ggacatgcat    44640

gttccatatg gcacacagga ctggggttca gtggcctctc tggttggatg attagttcct    44700

gcagccccaa accaatcctc caacctcaga tgattatgtt ttatgagcaa gagggagaaa    44760

tctcatcaca tttttaggaa aaaaaaagat tttatgatgc aattaattgc aagtcatgca    44820

ctggtttgga ggctgttagc taagacctga tggcagcagg aagtggatgt ccccatagag    44880

ttgtgggacg cagtaggcaa tattattcag agccaactgg aggctcaggt caaacacagc    44940

tgtttgtcag cataagatgc ccaagccgta tcttcccact gactgaaaag caaaattatc    45000

agatattgtg catgtgaata ttaatgcatt gcttttctct ttggaataat taatacttgt    45060

attattgctt ttattaaaaa tagcctatgt tagccaggct tggtggctca cacctgtaat    45120

cctagcactt tgggagggca aggcaggtgg aacacttgag ctcaggagta caccaccagt    45180

gtcggcaaca tggggaaatc ccatctctac aaaaaactac aaaaaaaatt acccaggcat    45240

ggtgtttcaa gcctgtagat ccagctactc aggaggctga ggtgagagaa tcacttgagc    45300

tctggaggtc gagactgcag tgaagccatg attgtaccac tgcactccag cctgggtgac    45360

agagtgagac tctgcctaaa aacatgtatg tgtttttaac taattttttt aagtttttta    45420

gtgatggggg tctcactgtc ttgtccagac cagtcttgaa ctcctggcct caagtgatca    45480

tcctgcctcg gcatcccaaa gtgctgggat tatacgcatg agccaccatg cctggccaac    45540

tctacttttt agtatatgat gatttgtctc tgtgtcccca gccaaatctc atctcaaact    45600

gtaatcccca catgtccagg gagagacctg gtgggaggtg gttggatcat gggagcagtt    45660

ttccccatgt tgttctcatg atattgagtt agttctcagg atatttggtt gtttgataag    45720

tgtctggcac tccccacttc actctctctc tctctcctgc caccatgtga gacgtgcctt    45780

gcttcccctt tgccttctgc gatgactgtg agtttcctga ggcctcccag ccattcagaa    45840

ctgtgaatca attaaatctc ctttctttat aaattaccca gtctcaggta gtatctttat    45900

agcagtgtga gaacggacta atacagagaa ttggtactgg tagattgggg tactgctata    45960

aagacaacct gaaaatttgg aagcaacttt ggaactgagt aacagacaga ggttgaaata    46020

gtttggaaag ctcagaagaa gacaggaaga catgggaacg tttggaactt cctacagact    46080

tgttgaatga ttttgaccaa aatgccaata gtgatatgga caatgaagtc caggcttagg    46140

tggtctcaga tggagatgag ggacttattg ggaactgaag caaaggtcac tcttgctatg    46200

ctttagcaaa gagactggtg gcattttgcc cctgctctag agatccgtgg aactttgaaa    46260

ttgagagaga tgatttaggg catctggcag aagaaatttc tatagcaaag cattcaagat    46320

gtgacctggc tttttctgaa agcattcagt catgtgcatt cacagaaaga tggtttgaaa    46380

ttggaactta tgtttaaaaa ggaagcagag cataaaggtt tggaaaattt gcaacctaac    46440

tatatggtag aaaagaaaaa cccattttct ggggaggaat tcaaactggc tgcagaaatt    46500

tgcataagta acaaggagtt gaatgttaat agtcaagaca gtggaggaaa tgtctccagg    46560

gcatgtcagt gatcttcaca ccagcctctc ccaccacaga cccggaggcc tgggagggaa    46620

aaatggtttc atgggccctg tgcagcccca ggacttggca tcctgcatcc cagccactcc    46680

agctccagct gcagctaaaa ggggccaagg tacagctcag gccattgctt cagagggtgc    46740

aagtcccaag ccttggcaac ttccacttgg tgttgggact gcgggggtgc agaagacaag    46800

aattgagctt tgggagtctc cacctagatt tcagagtatg tatgaaaatg cctggatgtc    46860

caggcagaag tctactgcag gggtgaagcc ctcatggaga acctctacca aggcaatgca    46920

gttggagccc ccacacagag tccccactgg ggcactgcct agtggagctg tgagacgagc    46980

accaccattt tccagacccg agaatggtag atccaccgac agcttgcacc atgcacttgg    47040

aaaatccaca ggcactcaac accagcccat gaaagcagtt acaggagctg taccctgcag    47100

agccacagag gcagagctgt ccaaagccat gggagcccac cccttgcatc agcatgccct    47160

ggatgtgaga catggagtca aggaagattt tggagcttta agatttaatg actgcccggc    47220

caggtttcag acttttgcat ggggcctatg gcccctttgt tttggccaat ttttcccatt    47280

tggaatggaa actcaatggc tgtatctcca ttgtatcttg gaagtaacta acttgctttt    47340

gattttacag gcttataggc agaagggatt tgccttgtct cagatgagac tttggacttt    47400

tgggttaatg ctggagtcag taagactttg ggagactgtt gggaaggcat gattggtttt    47460

gaaatgtgaa aaaaaagatg agatttggga gggaccaggg gcggaataag gtttggctct    47520

gtgtccccac ccaaatctca tctcaaattg taattcccat gtgtcaaggg agaaacatgg    47580

tgggaggtga ttggatcatg gggcgctttc ccccatgatg ttctcatgat agtgagtgag    47640

ttctcatgag atctggttgt ttgatatgta tctggcactt ccctcttcac tgtctttctc    47700

ttgccactgt gtaagatgtg ttttgcctcc cctttgcctt ctgctatgac tgtaagtttc    47760

ctgaggcctg ccagccatgt ggaactgtga gtcaattaaa ccttctttct ttataagtta    47820

cccagtcttt atagcagtgt gagaatggga gaatggacta atataattcc actttttagt    47880

atgtaaaata tgtgtttggc cagagagcca actttttaag aattgtttgg tgctgccaat    47940

attcctgaca ccagtcccca aggggttgtc tttgtgcata attcagctct gcaagtcttt    48000

accaagcccc atggtgtgca ggcacagggc aatgctgaac acactcagat atgtgttgtc    48060

ccaggtgcta ctcccgtcac tgtcacccgt aggtactgac atgagtttgg ggtgtatctg    48120

aagagcctgt gataaagtcg ggggaggctg agtataccca gtcatgccct ggtgcatttt    48180

gtacctgaca gctcctcaca gctgctggga cacactccga gcacatctca cagggtgtgg    48240

acgactgcca ggaggagggg ctggtgtgtc cttggagtca ccagaaactt ggcagccctc    48300

cctaatgtca gattccttca tgtctgagga ctagtgctgc cagtactagt gcagagaatg    48360

gagtcagaaa atgcaatcaa gtcattagtt tgcttgaact gtcttttatt ttgaggaagg    48420

gtcaaatgga agcataggat agaataggca tcttcatgac aaagtaacat gtgcccctgg    48480

caacccacat tctactttcc gtctctgtga atctgactac tctggggacc tcatacaagt    48540

gggatcacat gatatttgtc ctttcatgac tggcttatct tacttagcaa aatgtcctca    48600

aggttcatgc atactgtagc atgtgtcaga aagtctttcc tttttaaggc tgagtaatat    48660

tccattgtgt gcatatgcca tactttgttt atccatttgg gatccatggc atttagaaat    48720

aaatagatct caaattttta gaaagttagc tgcattttta ttttcctttc atttccagtc    48780

ctttttcctg gtgttctttg tggctggcat ttaaaatgca gacagtgcca acaagcccag    48840

cttatccatc ctgttcagcc ctctgctggc tcctcttaag acccagagac attgcccctt    48900

ttagtaattt aataaattag taagtctcaa ggctttaaaa caggttttaa ttttatttta    48960

gtaccagcat actctagttc caaatgcctt ggcgttgctt gggggctctt ggcatgggga    49020

taaataaata aatggccttg gaactgctgg agtagtgaaa tgtgtaatga aacacctaat    49080

aaaagatgtc tttaaagatt acatgcttgg actcagtggc atagcatccc attggcccct    49140

ggaatataca gtgccccagg acggggagct cgcccccacc caagctgggc ttggctgagt    49200

gccctatagc tgttgctccc cacacaggat cgagcttcct gagctgcctc acggacaggc    49260

agcgcccaca tacatagtca caactccttt gcgcattcaa gggcagaaag caccagactg    49320

tacaatgcaa gccagacagc agggggcaac tttttcaaat caccaggctg gtataatacg    49380

gtgatcactg aaaccttgcc ctttgcacca cgggaaacat ccaagcaggg acaccctagg    49440

ccttctgctc atgtcaaagg gctcaaagca cctccccggc gtcagttcct ctgggacctg    49500

caggtggcgg cgaccatagc tcctggcctg ggattagaag cttggcctct gcggtcagct    49560

ctctggctca gccttctccc ttgactctgt gacctcagga aggtctggga ccggctctgt    49620

gccacagctc cctcctctgc acggtggggg tgctgcagcc cctccctccc aggcccagac    49680

accaggaccc agggcctctc cttgttttgc tgcctttgcc caccctatcc cccaccctgg    49740

cacttagccc agcagggctt cgtaaggtct gctgagggca ggaatgtggg ccaggtctgc    49800

ttgtgaagga gcccattatc aatccaggag agcctgcttc acccacagcc agattaacag    49860

ccccatgagg ttagaggcaa cagcattggc tccatggcca ttgttgccgc agccatagtc    49920

aaactatttt aaattatctg aaagaatata ccattcctgg gccgggcacg gtggttcacg    49980

cctgtaatcc cagcactttg ggaggccaag gcgggtggat tacctgaggt caggagttca    50040

ggaccagccc cgccaacatg gtgaaacccc gtctctacta aaaatacaaa aatttgccag    50100

gcatgttggt acagccctgt aatcccagct acttgggaga ctgaggcagg agaattgcct    50160

gagcccagga ggcagaggtt gcagtgagcc gagatcgtgc cactgcactc cagcctggct    50220

gacagagcga gactctgtct caaaaaaaag aatataccat tcctgccgaa cagagacaga    50280

aacaggaaca gagtgtttgc tcctacgtgg ctggatagca attgcctgtg tacattcctg    50340

agaaaccaca atctacatca agccttttac attcaaaaca cttccacatg cattcacctc    50400

agtttaccct ctgagaaatg agtgagcagg aaaacctgtc tccctgtttt ggaagcaacg    50460

taactgaggt gcagtgggtg gaaatggtat gcaaggttat aggctcagag gaattctagt    50520

ctctgctcag ccccgggctg gcatccagcc ctctgcccca gcctgaggtg tgctgcggag    50580

caacacagag catcctggag aaaggagggg tgctcagccc catggattca tctcccccaa    50640

actggagagc agacaccagc caccaagaaa gagccaagaa aggatggctg ctgttactca    50700

acacaccagg ccacggaaaa tacgcggagt cttcgctctg gacattctgt tgtgctcgga    50760

agtgagtcct cccaagcccg tggtgactgc cccatgtcac actggttctg gataattcgg    50820

actagtcacc acctgcccca gcaatctctt tttcaaaaag tttgtccagg gcttcggtag    50880

taacatcagc tctttcacct tggaaaaaag gcacagggta gagagatgaa tacggtgtga    50940

ttgcagttta atctgtatcc cattcataca taatttaact atataaagaa tgaggtgagc    51000

cagaaatgaa aggttttact ctgatcccca agctctgagg gatagaaagc ctcccctctg    51060

tttctcccag ggtgcagcag agccctttgg agtcggagca gacccgtctc aggtgctcta    51120

gctaggtacc tctgctgagc ttgcccttct caaggccttc ccgttactgt acttgaaaag    51180

agaatgacga agaaacgaat tctctttcaa accggtagaa caagaccctg agtttgacag    51240

gaaggatcca aatttatgag ttctttgctt catgctggga ctcgaatgta agggagggaa    51300

aaaaagccca ctctgaaagg gacatgtaat ggttatttat agccctgcac catgcgggtc    51360

acctgcccgg tgaaacgcca tctgtgccgg gttacctgca cgtcagcgaa ggggccggga    51420

aggcatggtc taatcccagg attaggagca gggagaaaat ccatctattg aatcgttcaa    51480

aacaaacaaa caaacaaaaa tcctacccgc tcaaacttaa aagactggga gcctgaaaat    51540

gtttttgttg ctgctgttga gttttcttag cgcgcctcct cctgaagttc tcagggcacg    51600

aaccttcgtg agagtccaga tggccagggt ggtgcctggg agcgaagctg gcttcgtggt    51660

aaaaggagag gcgggaacag gaacgcgctg gaaccgcagg gctcccgccg tcttgaaagg    51720

cctctggcgt ggaaagcagg tggcggaacc gcccgcctca cggcctcact cagcgcagac    51780

tcacaaaatg aaggcaccat ttatgtcttc tagaacggga gggagacggg gacgctggcc    51840

cctgccgtcg ccgtggttca tcgtggttca cctggcctcc ccgggaactt gccaactgcc    51900

acaggtccac aggggtggga tgaaaccaag tccatgcatc cacgcccagg ccccttgact    51960

cgcttggagc ccttcctccc ctcagcccca gccatcgcca gcctttctct tggctcccag    52020

acctctgttc ccaaagctgt gtagaagtgt cgaaagttga gtagatccgg cattgtgcct    52080

cggctctccc acctctgtct gtgtgacctt agcaagtcgc tcaccctctc tgagccgcca    52140

ttgactccat gtgttatgtg gggagtagtg agtgcctccc ttgcaatgct ggggaggttt    52200

agtgacacgt ctggcgctgg ataggccctt cacgaatatg ctcagcaggc tgagagatgg    52260

ggcctctgcc cccagcacac acacctgcag gtccacttcc aaacacaggt tccggaagaa    52320

gcccagcgaa ctttctctga ggcacctgtg gagtttccat cacacaaggg gcacctgaaa    52380

ggcagccacc ttccccagcc agcagggaac cgtggcatgg acaggcctct ctgtgcagca    52440

gagctttgtc agctgtgacc tgataagctc ccacctgctg tcgggcactg gcctccttgg    52500

gcatacacgt tcactgaggc tgggaagagg ctgctgggac cagggcagaa gtgcccttgc    52560

gtagtgaggg cctcacacat gggctgtttg cttctcctct gagccaattc tgtgtgcgag    52620

cataatacac atcctaggag agaaggcttg ggttgagggt gattatttat aatggcagtc    52680

aggttgttgt aagacaccat cttttggaag tgacttgttg agaactagtc cctgggtgcc    52740

tctgggccaa ggagatcgtt tttcttctcc ttctactctt ccctgttggc catgccccca    52800

gctggtgcag aggaccctca gagctgagtg taagttaccc atggcagctg ccagctggtc    52860

aggaagggtc gccaggaagc ccctcaaagg gaacagctca ggggaagctg tttggaagct    52920

cagtgcctcc gccttgccct ggtgactggg aggaaggctg tgagctacca ggactctcct    52980

ctggccagag cagattcaga caaaagccag gggcagcccc tttgggaacc tgcctcacgt    53040

ttgagtcacc gacatcaaaa gcaaggtcag gactgcccag gcccagaaaa caaccaaaaa    53100

ccattttgca aatgtagtct tagcaaaaac aaatggaatg ggcaaatgga gaaacattgt    53160

ggtttacgaa tgcagtggaa tacgattcgg caataaaaag gactaaagtc ctaattccca    53220

caacgcagac gcatcacagg tattatattc agtgaaagaa accagctgcc cgattccatg    53280

tatatgaaga tctagaacag gcaaaatcgg tttaaattta tagtgatgac cggtgacagc    53340

ccagcgtggg gcagattgat gatcaagggc gcaagagatg ctctggaaga gatgggctct    53400

gtatcaagcc acagggggtg tatatacgtt atcaaagtct cccacctgta actggaaaat    53460

gtgaagctta ttgcaagtta attacaactc aataaacgtg attagtttta aaactatcat    53520

ctgagcaata agaatacaaa aatctgtgcc actaatcagg acatcaactt gtaggttctt    53580

ggggaacatg cagagtctga gaacaccact ctcatcattt tgcactgttg cccctggaag    53640

cctgccccgt tcagacccac gtcatcgcgt ggtgtgacgt gttgtaattg cgcttggtct    53700

ttgctcagaa gctgcttctt tgttattcta cacgtgactc cacattcaca ttgtgtgacg    53760

acggcactgg atgcttgata cagaggagga gcagagagcc tggctgctct cacctccgcc    53820

cgatctgggg ctcaggcatg gcccagggga gcccagagta catgggccac gcactgagat    53880

tcccactact ccctgggctc atagtggctt caaaggggca gctgaggtgg ggagtgggag    53940

gcaagggctg cagagtagga ggcacgtggg ccggctcggc catggaggag ccacacgtgc    54000

tttgccagcc cccatacgtc ctccctccct gcaccttccc cttcagacca tccgagccat    54060

cctgggaggc tcagcctcca ccacccatgt gggcaccttc tgcattacct acaatagcca    54120

gcctgagagg agcagcaagc cctctgcagg ccctcgggac acgtaataat ggcagtcatc    54180

tttaccgcct cttcacgtca ttgcctgcgg cagctctgtg ctattttaga ctctattgat    54240

cctggtgcca ataaatggtt catattcttc aacttcctta acttagaggc tatcgtctca    54300

gtcaaattga tgtcttctgt ctggctgaca tagcttggga ttctagtagc gtgtctttca    54360

atgattaagg attacgttct tgttttgctt ttgttgtgaa gcagaatcag cgtcactgag    54420

acacgttcat gcaggaggcc tcgtctccat cacaccacaa atactttaag gtgccaactt    54480

tctgttctct agtggagtcc agatccaaca ggaatggctg ggtctggggg aggcagggca    54540

ggctgaaagt attgctttcc aaatatctct gagctgatga gagcaaagaa atgaggacaa    54600

gagctgaggg aggacccagc acagtagccc attggcagaa aacaagaaag agttcttggt    54660

tttatcagaa tgcagttaag caaataactc attcatctat tgctgagaga agagggtata    54720

gcaatggcct tacaggggat acactgtgac tgcacttcct aacgggacat gttctcctcc    54780

tcccagccct cacccacact gttccctctc tctctacttt tccattgtga ttcctggcta    54840

actcttagcc atcatctctt cttgggactt gggacagtcc tcctgacctc cccacctggt    54900

aatctgtcat tagcacccat tttcacatac gcatactctg cactagacac ttgaagtcag    54960

gagttcaaga ccagccttgc caacatggtg aaaccccatc tctactacaa atacaaaaat    55020

tagccaagtg tggtggcgca cgcctgtagt cccagctact acggaggctg aggcaggaga    55080

atcactggaa cctgggaggc ggaggttgcg gaggttgcag tgagctgaga tcgtgccact    55140

acactgtagc ctgggtgaca gagcaagact ccatctcaaa aacaacaaca acaaatggaa    55200

ggatgagtgg catgtgtatt aaagtgctga agagtggctc ctatcatgtt tcaacaaaac    55260

ttcatgttac tatgcttata taagagtcct agagtggcca ggcacggtgg ctcatgcctg    55320

taatcccagc actttgggag gctgaggtgg gcagatcatg aggtcaggag ttcgagacca    55380

gcctgaccaa catggtgaaa ccccgtctct aataaaaata caaaaattag ttggatgtgg    55440

tggcgggtgc ctgtagtcgc agctactcga gaggctgagg caggagaatt gcttgaaccc    55500

aggaggtgga ggttgcagtg agccaagatc atgccactgc cagcctgggc tacagagcaa    55560

gactctgggg ggtggggcgg ggggggaaga agtcctagaa aaacttgcat tttgtaattt    55620

aaagcaatgt gttagttatg ataacttttc tgatttcacc ctgaaaatgc tttccctcaa    55680

ttttgataag gcaaaaaagt agggattttt tttttcaaaa cttctccaag cttgtcagtt    55740

cgacaagatc ctttcagctc tgaggcattc aatgaaacag aaatgaaatt gtgaacacat    55800

atctttacag caggacattg ggatgaggat aagtgctctc cctctgaact tctgcatgga    55860

tatttgcaag ccacgttatt ttcgtgagca atcctccaag agtgcagagc acccgagcac    55920

cacaaactgc gggaaatgca gagagagctt ccttcctctt tgggacgcca gccccagttc    55980

tgtgtacaag tgcacacaca cctgcttcat aacataatta gcattctgag aagcccaaac    56040

ctagtctgac aagcagcaat aaccatgttg gtgttcagaa atgtttttag gccacgactg    56100

tttactgcac ttcagaaatt atcatcgtca ctggtttata tgtaggaaaa taaagactag    56160

cggaaaaagt tgagtcaaat agaaagatga gatgtgaaca gatgtgtcca aaatactgat    56220

tttccatgct cttcctgcct ctgtgggttc tgctgaagat tcagtgatgc acagagagtt    56280

ctgaagaatt ggacatgctt atttgtatta gtagtgatcc ttcaaaagaa aatctagaag    56340

taaataagtg tttcatgcat tatatttatt attctacgtg tgcaagaata tctgttttct    56400

gagtattatc tcaattcaaa ttaacaaagg aaacttggga acttggattt taaactttca    56460

actcaaacct acctctgtcc acgtcttttg ggaaggcccc acccgagggc tcagggccat    56520

ttggtttgcc ctcatctgtg cctctccccg caggtccact gtgcatgggg cctgtctggg    56580

tttgccacat acacacacat acattcacac acatacattc atatgcatac actcatacac    56640

agatacacac acacatacac acacatacac tcacacacat acacatcaca tacacttata    56700

ctcacacata taaacataca catatacaca cacaaacata aacatacaga cactcacaca    56760

catatacaca cactcatata caaatacact tacacataag catacacaca cacataacat    56820

tcacacactc acacacatac actcacctac acttacacat gcatacattc atacacatac    56880

acatactctt atgcacacac tcacatatac acatgcatac acacatcctc acatatacaa    56940

tacatacact cacacatagg tgctcacaga tacacataca ctcacgtgta tgcacacact    57000

cacacccata tgtttggggt gggcaacacc cttgagacac ttagggcctg agagaatgca    57060

gggacacagc ccaccccttt gaggggctgc caaaggtcag tttgcccctc atagccctga    57120

aatcttcacc agggagtttg caaatgaaag attttcagtg cagtgataaa gaagagtggc    57180

tgcttataaa cccccatgtg atgctgtttg aaactctggg gcccgccagt gtgctctgtt    57240

gccagtcact tctgtttcag cgtcaccctc cactccagcc ttgggaagga cggtgcctgt    57300

ggtcttgcca agacgtttgg cctgtgctct gcgtgtctgt tccccggcac agcactgtgg    57360

ggggcctccc ctgcctggcc agagaggctg ggaacaggac cggctattta atttgtggga    57420

cccagtgcaa aatggaaatg ggtcagaaat cactgaggac ttcaggctgg caaggccagc    57480

aggacactaa gtgctgcatg gggcaggagg gactcccagg ctaccttctc tgctttcctc    57540

ctgctccggt gaaacagatc cgactaaagc agaagtggaa agagaatgca tccctctcct    57600

cccaatctaa tattaattag cactactcag ctgagacagg gaagattcag agctgtaaat    57660

cacatcaaat ggaagtgttt tcagctgctc tgatggtgac cttgcgggct ccctacaggg    57720

aagggaggtc tgtctgggtt gatgggaagt gggggcttca gggaggcggg ggagtactga    57780

atcctgctgg gtgtggggag gaggccacca gcagcctccc cttgggtctt cctggaggaa    57840

ggagagcgtg ggaggccggg gaaggagagt agcgctgggt gggcagggag cccgcagcca    57900

gctctgtggc tgcctcccag acacaggcag ttgccagcac cttgcctccc gccatggaag    57960

agcttgtgcc catggagctg agtgggccag ccacagcctc tcccctccct gtccgtgatg    58020

cggtcaaccc aggcgtggca agccctgctg ggccaggcca ggtaagcacg ctggaggggc    58080

cacagacaaa agggacatcc gtcctacaga ctttaaaagg taactccgaa ccatcaggcc    58140

tgccaaggct tcccacagcc acctggcctc agctgcttcc cacagatatg aggtgtggcc    58200

ctttcaggga gaagcttttg gaagaggtag caccgtcaca gtcaaggggg gcccaactgg    58260

gtggaagaat gggaagtccc ggaggctgga ccatctgcca gccgaggcag tgactctgct    58320

tctcctaaag gtggtgacca gtagggagga cggccacctt cttcctgcag tgggcactgt    58380

ctgtgctctg gaggcagccg tgatgacaag tatagacagt caaagccaca ccaccaaggg    58440

tgaaggccat tccaagaggc gagcagctca gagaggagac tgagtctagg ggaggacggc    58500

taggaaaggg ggccaaactt gtatataatg atgtcttcca tgtctggctc cctggacaga    58560

taaaggccca atagagcagg gaccctatct gtctggcacc gtccttaggg cctataagat    58620

tgccacatag tagcagctcc acagctcttt gttgaataaa tgaatgaact ctaacaagat    58680

taagggaatc ggtgtctagt gcagagtctg cgtgtgtgtg tgtgtgaaaa ggggtgctaa    58740

tgacggcatt tgttctttgg aagaaggcca gaacttaaag agggagagac ccagccaagg    58800

ctttcttcct gggctcccag aaggaattaa acattaatta aacattaaac attctctccc    58860

cacctcagca agatgttgct aggagatcgt ctagaccagt gcttctcaaa ctttaatgtg    58920

cacacagacc acctgcagat ctggttgaaa agcagatccc agacagcagg tctgggcggg    58980

gctgagattc tgcatttcta atgagctccc agctgatgct aatgctgctg gtccaggggc    59040

cccactttga gcaacaaagt ggcaatggtg aggattaagc catggtagtg cctggctggg    59100

gtctgagctc agtagtcata agctgatgtg attacagctg tgtcatcatt ctagatggga    59160

attgaggaag gaagggccaa aggcagagga agagagagca ggtcggggaa gagaagctgt    59220

taattcaggc aggagtggca gaccttttcc gtaaagcgcc agatttgaga tattctagac    59280

ttacctggtc atgcggtctc ttatatcatg aaatgcctac aggcactagg taaccaacag    59340

gtgacgcttg actccaaaag agtgtgttca cagaacctgc tgggtggcga ctggcttcac    59400

aacccctgaa ctggatcact agccaattaa ctggttagtt ccacaagtta agcagcagcc    59460

ttgtctgcct caggtgggaa gagacatttc cacgctgctt tggtttgaat gttttcccca    59520

cagtttatgt gttaaaaact taatccctta atccccagtg aacaggtttg aaaggtgggg    59580

aggtgatgag gtcgtgaggc tctgccctca tgaatgactt aatgtcatca tcgcgggagt    59640

gggttcgtta tctcgagagt gggctggtta taacagtgaa ttggccctgc ttgcactctc    59700

ttatcaccat gtgatgccct ctgccatatt atgacatgga aagaaggctc tcaccggatg    59760

cagccagtcg ctcttggact tcccagaacc agaaccccaa ataaacttca gttcattagc    59820

cagtccgtgg tattctgttc tagcagcaca aagcagacta agacaggtgc tccctctccc    59880

catcactgtc acaaatatgg gagctcagtg tgcacgaggc tggagcccca cgtcagtcag    59940

gtccttggtc tcatacccca gcagcatcgc caggcactga tggagattgg ggatccccaa    60000

agtaaaacaa acaggagatc acgactggga gccgtcagcc ccccagcgcc cagtggccca    60060

cctcctgcct gtatctgcag tctgagaagt gggatccaaa ccacaggctg ccctgtgctc    60120

ccctccccca gaccccactc accctctcag agaattggta acaataatga aacacatcta    60180

aggccacaga cttttagttc tgctttgtgt atctattttt cttttctctc tgcttgggtt    60240

tacctgggaa cgttttaatt gcgcctttcg ataagtgctc ctggttgaca ctaaggtgcg    60300

gcaggcccag cccttctcag ttattcaggg aagccctccg aggctcagct ataattagaa    60360

gtcaattaaa ttagaaacca ttcatatggt tcttggaagg cctccagccc tgctgagagc    60420

ctctggccct atccacagac tcagtggaaa cctatctctg ctaaccccac catcctgaag    60480

ccaagtccag ggctgctggg agggggaaca ggctcctatc agttcccctt caggcctttg    60540

cttgcaccca accctccccc acctgacggg ctgcaggtcg cccttgcctc cccgccaccc    60600

cgatctcccg tcgctgcctg ccccagcttg ctctgttgct agaaggaaaa cacccagcga    60660

gttcaccact ggggtggctg gctcctcaat cttgcctcag tccatttagt gttttccaaa    60720

cggtaaatgc aacactaaag tgcaggcagt gtgtgggaaa aggcagtttt tgaacctcat    60780

caagagggtc tggaaacaga actcttcctt ccccaaagcc acctggaggt ctccaccaag    60840

tgagacacct ccaaggtgac tgggccaaca gccgagaccc aaggaaagac ccaggaccac    60900

tgctgtgctt tgccagtgac cccagtcagg tctgtcctct gggatctccc ctgggacccc    60960

cttctcccac ctattcttag agcagccagg gacacacgct ttttccttta tcacagaatt    61020

catactctct cttctagacc actcagacaa tacagacctg cataaaataa aaagtgaatg    61080

ttccccagaa tgctccctca gtccttggtc acccccaccc gatttcagtt actgccaaaa    61140

aaatctttgc tggaagttca gcaggcatcg ctccagacct gctttcatgc atttagaaac    61200

tttacaaata cacccggagg cattcttctc tatcatttct ttctcaccca acaacaggtg    61260

ttacagccct gcttggtgtt ccaggaaact gaagttcctt tggatttttt gtgggtgttt    61320

atttgttgca atgataaaca agcgtaccat cttaaggccc tgccaggatt ctgcccaccc    61380

tcttcctacg ggagcgaggg catgtgctgt tgtactcggg aggcaggaca ggcgtgctcc    61440

ccagggatct ctggaaggcc tgcagactgg aagctcccta gcagccagtt aactgattag    61500

ttccacaagt taagcagcag ccttgtctgc ctcggatggg aagagacatt tccatgctgc    61560

tatggtttga atgttttccc cacggtttat gtgttaaaaa cacatatgta cttggcattg    61620

ggtgcatctc ctaaaggacc attctctttc cagaaatctc agtgaagaag cccttaagtc    61680

ctgggggatt tggaaaagaa gattgtccat gtcagtcccc actgacaggg cccttggtct    61740

tttgctcttc tccaccgttc cctggctgct gacttacaca gctctcacct ccttctccaa    61800

cttaattctt aatttctttc tttttttttt tttttttttt ttttgagaca gagtctcact    61860

ctgtcgccca ggctggagtg cagtggcaca atctcggctc actgcaagct ccgcctcccg    61920

ggttcatgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg tgcccaccac    61980

catgcccggg taattttttt gtatttttag tagagacgag gtttcacctt gttagccagg    62040

atggtctgga tctcctgacc tcgtgatccg cccgtctcag cctcccaaag tgctgggatt    62100

acaggtgtga gccaccgcgc tcagcctctc caacttaatt tatttccaat aatctttcgc    62160

taatttctac ctaatgcctt taggctgttg caggactttt ccaaaagaaa gaaagaaaag    62220

gaggaaggga gggaaggttc ctgtgcatca tggcatatgt tcgtcacggt gtttttgtgt    62280

gtggtattgg gaattagttg gttttcatga ccaatggtag cttgctaagg acgagagaat    62340

tctgagggtg aaaggtctta gggagtttgg gttccatggc ccagctggtc ttctgggctg    62400

tgtcagtggt tgattctgga aggttcctca cacaacccag catctagaag agtacttgct    62460

gttttgttgt ggcaagagga cagtgaacca gagtgcagcc actggggaat ttaggcgatc    62520

actagagcac attatctctc tttgtagagc caggctaatt aatacccaga ctaccaagta    62580

aaattgcttt gagtcagaaa cacaggtctc cattcagaaa gtgaaaaaac aagcaaaaaa    62640

aaagaaaaaa aaacccacct cctccttcaa gggaatgcat tcgtgtaata ttaatagttg    62700

gtgaaaagta tctgaacacc tgaacagctg cagccatgct caatcccttc aatcccttaa    62760

gtagctgtgt gacctggggc aaatcactta acctctctgg gctcccacta tctcaactgt    62820

aaagttaggt tattggactt gtccactttg atggacaacc tgttcttaac agagagaggg    62880

aagaacacta agctggggct gggagagcat ccagaggggc aaagaccaga atctaattcc    62940

tggcagtctc tccaggggtc ctcctaagtc ctggagccca gaggccagga ctggcctgga    63000

ggactccaga cttaaagctc atgtaaggct aggtttctcc aaaccctctg agcacgagaa    63060

acacaatcac taacctcggg tttaaccttg ggccctccgt gtgctcctag cctcctctca    63120

ggctccctcc caggcatggc tgcgaggctg ggaaggcccc agagtcagcc caagtggcat    63180

gggtacagct tcagcttcat gtctgctttt cttttaggat gtatagtttc ccctctgttt    63240

gctggaaggc accttatatc cagtggggtt aaataaaggt agccagaccc ccggctgggg    63300

tgctaccgcc agtgcccagc taatgacgca tgtctttcag gtgagccctt gggagaggat    63360

ggcccatgtg ggggactgca cgcagacgcc ctggctcccc gtcctggtgg taagtggtct    63420

gagcccctta cccccacagc accctcatcc tcatgatggt tggactgttt cttggcctct    63480

tcagctgtaa aatgggaatg ctgatcatag tccctcctcc acagggttct tctgagggtg    63540

aaatgaaacc aggcctgcaa agcacagaac tctgccccag gctgaagtta cattgatttc    63600

gttggtagct cccttcatag ggtctcatgg atataaacgt tcttgattgc ttgtttgtgg    63660

tgtgatacac acagccctgt gtctatgtga tgagctcatg cttgggggcc gcgcagctaa    63720

gaaagacttg gaagactcag acccctaccc ccatcctcct ggacacgccg gtgttctgag    63780

aagccactgt attagaggct cagtggggga caggggcgcc tcctccatga ccttggcaag    63840

tgcgttgatg aggagaactc agagcaggcc ttgatggtgg gatggggctt ggccagcagg    63900

ggtgaggcag ggtggttcta gtgggggctg gccgtgccca ggtgatcaac caggagccac    63960

tggagactta gcagcagtga gcactcacaa gcgggcacct tcccagaccg agcccccagc    64020

agagccccca ccgcagggca cccccttcct atgtcaacct tggggtcttg caggagtcac    64080

atgtgtttct aaggaggtac ggaggccaca acacccccct ttgttggcag gtgtctctga    64140

tgtgctcagc ccgagcggaa tactcaaact gcggtgagaa cgagtactac aaccagacta    64200

cggggctgtg ccaggagtgc cccccgtgtg ggccgggaga ggagccctac ctggtaagga    64260

cccagccctc ctggagcctg gtgcgctctc aggggaggcc tcctgcttgt ggcattgttg    64320

ccctgagcct gccttgctgt gtgaggggat gccagggtat atcaaaccag ccggtcacgc    64380

tccctggacg ttgagattga tggcaagagc tgccgtgagc ccaggaatgg cactcaccag    64440

ctaagcattc ataaacagat ttttcaggag ttctgaaatg tttttaaagg atcactttcc    64500

cactctaccc tgattaaatg agcgtcagat catctgattg gaagcaggat tgaaatattc    64560

tccagtacta gtacattttt tcctgagtgc tgcatctccc tccgcctctg ggcaagctaa    64620

gcctgagtgt tctgttcagc actaagggaa acctccgggg tttcagtgtc cggttcttgt    64680

agcaagctga ggaaagtcag atgccaagtg ctacctgcac tgcctgggca ttccagcagc    64740

tcgctgaatt catctcgggg aggctcagaa aaggggcagc atctggagcc tgagagtggc    64800

gaggagaggg gcaagcccag agcatgagct ggttcctggg gggttttgca gttaggacaa    64860

ctcaggaaac caaggcccgg caagagtagc ttctggagac agctggcacg tcactgccca    64920

aggactgtgg gccgagtccg tatggtttgg ctgctgcact cacctgtgtc ccctgtcctc    64980

tttccctgga cagtcctgtg gctacggcac caaagacgag gactacggct gcgtcccctg    65040

cccggcggag aagttttcca aaggaggcta ccagatatgc aggcgtcaca aagactgtga    65100

gggcttcttc cgggccaccg tgctgacacc aggggacatg gagaatgacg ctgagtgtgg    65160

cccttgcctc cctgggtaag cacaggccct cctggcaaac cctggcatgc tttctgcaga    65220

aaaccccgag gggctacggg caaggacctt gggaacaggg gtcatggata ctgcaggcct    65280

cggtgcagcc gcacacctgg ccttggtccc atcccacaag gagcagcatc caggacggag    65340

agtcctggcc cctccggtgg acaggcagcc catcaggctc tgcctctgtg tctcctaagt    65400

ggccattaac catcataata tcttctgacc accaaaagga aacaaattgc ttgaatactt    65460

acagtgcagt agcgcatgtg aaacactttg ggaaaaagaa aactaaaatt tcatgcaaaa    65520

gcagcatttt tagtatcctg ggaacactct ggggaagcta ctaataaaaa tatttgagtc    65580

atatgatacc tataatccct ccaaaatgat tatgcatcag aagtcttcaa aaagctgaaa    65640

atgcaattag cctgaaagag agaaagataa aatcttcctt tttccaggca tgacacctca    65700

gcaaattctg ccagggacca ggaaaataca gactctcaat ccccagaaaa tcctgagcca    65760

tgatcattgc tgcttcctcc ccctagtggc cacaacacat catgctttgc aagggctaca    65820

aatagagact aaagataaaa gcagtggtgg tgtccctggt acagctggta caggtgggag    65880

aggtgatggc agtgatgagg ctggtgggga caagggaggt gatggcagtg atgaggccag    65940

tggggacggg ggaggtgacc acagcttagt gcataaggca cactcagagt gtcctaggag    66000

ttgcagaagg acctctcacc tcatggctgg ggaggtagtg tcagcagagg tcttgggaga    66060

tttgtggagg tgatgcctgg atgagttagg ctaagaagta ggactaggac agaggcctgc    66120

aagtggagat gccgacgcca gagttcagag ggctgagcag ctgggcagtg cctggggctc    66180

tgattgggtc cctgtggcca gagcaagagt tgtacacctg ggggtgtgga caagctgggc    66240

aggagggcag ggagcagatg gaaccaggct ctggaaacca ccgctgaaga cttgagcctt    66300

ccgctcgaag ctgatgcagg tcaacacgca gactgctgag ccagggatgc tgtgggcagg    66360

gagagggctg gagcagaggc accgggggtg gaggagagga agaatctgag agccccctga    66420

aagacagcac tgaccagggg tgcagatggc actcagaagg ggaaagagat tcagaagagg    66480

atactcaggt gtctccatga ctggccatgt ggaaatagtg ccatttgtca gctgcagaag    66540

acaggagcaa gagggtgctt ggtggggagg tggagggagg atagaggttg tgtgtgtgga    66600

atttgagggg actatgggac atccagacct agatagctaa cccagagatg gcctgaacct    66660

ccaggcagag atccagagct gggaagtcac tatgcactca gggtgctggg ggccgctgta    66720

gtagaagggt tccccatggg gcaaattcct actgcaggga gagggtgggt gcaccacgga    66780

acctcgccga cctatgctgc tggctctggc ctggctacgg ttcagacctg agaaggtgtc    66840

catcagtacc cgaaggccag ggctgactct atggcctgaa gaccacgtgc ttggttctga    66900

tacatttacc agaaagtgtg taattactaa agaagttgga cactggaagg gtggtgagct    66960

ccctgcctct agaagaattc aggcgaatgt ggacagccat ctgcagaatt agtgggcagg    67020

ctgctctctg ggcttttaaa cattctttcc agtgctggaa tcttgatgcc tcccgcccta    67080

ctccatggga cagtgacctg ctcagtccac accactctca gcacccagga catagcaagg    67140

cccagcacac ctgctgggca ggcaagggac cctgtgcaga gacaccctca gcacgtgcct    67200

cagagtgcct tcgcactgct ccgcaggggt gcagacgatg gggacagttt ccaggttggc    67260

tccatgatgt gctgtgtctg ctcaaagcct cactgccagt cccaacgccc accaaaattg    67320

aaggcccccg cctcacctcc gaatcccagc ccctctcagg ggctcatgct gccccctcta    67380

ctgcagacaa ggcttcccca gggtaggacc ctggaggccc cacttcctct tacgaggctg    67440

tcacgctgtg tcacagagga ggatcacagg agtcttggca ggccggtgtg actagctcca    67500

tgaaaggctg cgttcattcc tgaatccaag tggctgtcag gctgtggatg cggattgcct    67560

tgtcccagtc tctcctgggc ccaggcccct gcctgcggtt tggcaggtgc ttctcctgat    67620

gctccgccct ccccacagtg tggccaggac acttgctgaa caatgagcag cacccgaggc    67680

tttcctgttg ggagaggttg tgtgggagga cctgggaacc aaaacaggag gaaaggggga    67740

gagagaggtt acgcttcctc acctctccag gcctcacccc ggaggagctc caccaccccg    67800

cgattctgga tggcgggggc agggggcagg acacagcgac tctgcactgg ttctgcacac    67860

caacacggtt ggaggaaaat gaacatctgg gaatctgcgg cgtcccttac aggcatgaga    67920

gtcctgaaga aaggaactct ctgggaaaat gtacacctat tgactgagag aaagtcagtc    67980

cttaaacaac agatcccagg ggacccattt aaactgactc ttgtcctggg ctatacacct    68040

gaatcaacct atgtagaaca ggggttgggg ggctagggag aaagtcaaat atggatcaaa    68100

aagtagcaaa ttagaccttt ccagaaagac gaagggaccg gacactctgt agctgggcca    68160

gagatcccta aatgaacacc tgatttcggg ttggtgacaa gcccaggcag aaaaagacag    68220

ccacatgttc tttgttgctg tgcagcccag gatgagagac ccaggtgtaa gccaggcggt    68280

gaggagttta gcctagtcct acagagagaa cctaacattt agaaatgttg catgcagcaa    68340

tacgtgctag aaaacggtgg cttctccttg tcaggaggca ctgaacactc actgggtgag    68400

gaaggacagt ttcataacag cctcttggag ccaatgtttt tttaaaagtt tatcaccggt    68460

caggctcggt ggttcacgcc tgtaatccca atactttggg atgccaaggc aggtggatca    68520

cttgaggtca gaagtttgag accagcctgg ccaacaggtg aaaccccatc tctattaaaa    68580

tataaaaatt agccaggcgt cgtggtgcat gcctgtaatc ccagctactt gggaggctga    68640

ggcaggagaa ttgtttgcac ctgggaggcg gaagttgcgg tgagccaaga ttgcttctct    68700

gtactccagc atgggcaaca gaaggagact gtttcagggg gaaaaaaaaa agtgtatcac    68760

ctttcaatat tccttaactg agtgacttga taggttgcat agcttgaccc atacacatga    68820

cccccacaga tgagggtggc cagcctgtga cagaaggtgc ctcgtgccca ggacaagtca    68880

aagacacagt cgtgggacag agccaccacc ctccccatgc tcaaaatgta gtggccccat    68940

tgggcaccca tcataaagcc gggtgttgtg catccgccgt gtagccttgg agctttaccc    69000

atgacagaga ccaagcccgg cacctggggt gtgaactagg atgggcagag aggccttttg    69060

gggcctctgt ccacctcagc atcaaagttc cacggagaag aacttggtgt cattcattca    69120

ttcagccaat gtttacagac aatcatcctt ccttagtacc tagcacaagg tccaaggaat    69180

agagacgtga acaaggcttg ccctggaggg cctcccagcc caggagcggg accaatagac    69240

gtgaacaagg cttgccctgg agggcctccc agcccaggag cgggaccaat ccccctaggt    69300

gggagagaga atgcgtggag gtagagtgag aaaaggtgga ggaggcaagg gcgaggaagt    69360

gaggcacaga ggaggtgaga tggggagcag gtggccacct aggagcctga gatgtttctc    69420

agaagtgtca gcgtgggcca gggacgttag aaagctgcag gttgacctgg tctggcccac    69480

atgcccgtga actcacaagg ccacgtggca gacacctgcc ttggcctgcc tcatagaaag    69540

aagtggcttc tggagggcag aaggtagatt tgcgagaggc ttagctgtaa aactggctgt    69600

cgtggcttct ctgggaggtg ttttgagatt ggttaattaa tgtttacaag atacacaggg    69660

atctgaggat aaagggcttt gagggagggc aggcaattat ggtcctaaca ttactggtaa    69720

cagtccaggc tcaggaaggc aggagcccac agacccccgt gccaggctgc tgcttagcac    69780

taccgtcagc aggggcctcc atggggcctg gctaataaaa aagagattag aaagcagcca    69840

tggaaatatt ccttctcatc ccagttcttg aatcgcaata gggaaagtgt tggcaccgct    69900

cacgttattt aatcgactac tcacagtgtg acaaatggct ccatgctctc cgctgagcat    69960

ttgtttatgg aaaatgggcc caggctagga taggagctag agcctgcaga gggaaggcgc    70020

ccgagctggg agccccaagg agagggtggt gccagcaggg gctgtgcctg ggagcgggac    70080

ggctgcaggg agcacagcca cagggcagac ccctgagagc aggacctgag cagtcatata    70140

gccacggggc tggcactgtg acatcgggga gctgaaagac ataatggaac atcactggga    70200

gctgaaggac ttcaaacaga gctactgtga atgatttgtc ccttgcactg tgtgtgcagc    70260

cccagcgtaa aggcttgcac ttccaagggt gtcttctgtc aagtgctttc tgagaaggag    70320

gcacttacaa cctggttgtg ttgccagcta tcatgagggc cacctgcatt gacctctctg    70380

gacagcacaa ccgtctgtct cctgcagctg cactctggtg gcattcagca gcagtaaaga    70440

tggcttggga gttccaaggg tcccagaggc acactgatgc ctataatccc actaggctgc    70500

aggctctggg gagggtgctc acagagggca tgttcctcct ccaggaaggt ctggccttgg    70560

ttggtgtgac ccctgggggg ctaagcaggc cctacatgtg ggggcacagg gatatttctg    70620

gtggatgatg tgatggcaca cacactaaac acagccacca gagagaggaa ccagaaaggg    70680

gctgagatca aaagaaaggc ccacgttggc agctcaatat tgttaaaaga atgctccatt    70740

tcaagacagg ctgaaacccc aaggaaactg agtggacaga gcaggtgact gagtgggcgt    70800

ggcctcatgc ccgacttgat tgtgggcctg cagactggcc accgtgctct ctgcaccagt    70860

ccctgcctgt gtgctgtcca gctcacctgt ctctgttttg tcttgtctct cccccgtagc    70920

tactacatgc tggagaacag accgaggaac atctatggca tggtctgcta ctcctgcctc    70980

ctggcacccc ccaacaccaa ggaatgtgag tgtctttgtc cttccaccag cacggtattt    71040

gttcagcacg gatccctttc actacagagg gtgtaggaaa gagccggtcc tggcacctgg    71100

acaaggtgaa tcacagtaac agcactagtg aaagtgctcc tgtggcctgt ccaggcaggt    71160

ctatgaaggg agggatgttt gccacatctg agccttgagt cagaggctga ggttctagtg    71220

caggttggcc accagctacc tgacaagtca cttaacctcc atgagcctcg gttttctcat    71280

cggtaatatg ggggtactaa catctgacct tcccatctct cacggtcatt gtgaaaacaa    71340

aggagatcac agaggcaaag tactactatt ttgcaaagta ctacaaagtg ctaggtgaca    71400

gtgaggccaa ggaaaatata aatgtgatca caattaatga aacagattcc acaaagcaca    71460

tgtaaacagt ctcaggagtt tataatcctg ccttggggtg tttctttcct gttatccttt    71520

ctggctttca tgggcatctg tttatgacga agggccaggt acctctgcct cagaggaatg    71580

tgctgtgtag actcttagat gtgtggtctg gggagagacg gaggcaggta ggacaagcag    71640

ctgggaggaa gctgggtgtc tggtgccggg ctgcaggagc acttgccacc ctctggctcc    71700

ttcaagggtg gaggaggagc tgaccctggg accctgcctc tctttgctct ccataaggcg    71760

ccactacccc catgtctcat aataatgttg tccaggagaa gaaggagagc ctgcgtctta    71820

tcacgctgga aagaagggga ggagcaggaa tggggcgcag catctcctct ctccttttgg    71880

tcaagccagg aggagggttc tgtgctgtgg gctgtgctgc aggaggagca atgcatgagc    71940

cctgcaccaa tgtgtttgct cgtcttcaaa gccattttcc tggccagcca tatgctaatt    72000

aattcacaaa ttagaggagg ccgcagctcg gctgccagcc tgactcatgg tgaagccagc    72060

tgccatggcc cgcatgtcct ctgtggggat ctaggctgat tcaaggccag atcattctgg    72120

gttgaagaac cagtctggaa agatgtcaga cactccccac ctattcacaa aagcatcttt    72180

gcctgtggaa cctgggagag gagcagtcct cctcaggggc ttttctgttc aagagttctc    72240

acatggcaca gccttcaatg ttcaatgtct ggcagccaga gcagacttga gtcacggcag    72300

gggcgcctct ctaagtccag caatgaggtc tatcacatgt ggaaagcaag caaagtcccc    72360

tgagtcctca agattttaaa gatgagcgca ccccactccc acccccagcc cttgcctgct    72420

ttactgaaag ccggctccga ggaaagcctc ggggtagggc cttagaatcc ggccctgaag    72480

gaggtcagca gagaaataga cagtcctgct gtgttcccat tagaggcccc ttgggcaagg    72540

ccccagacct cggcttgccc atctgggaaa tggggagatg cggccagata ggccttgggg    72600

tggatggagc cctctgggtt agggcctcgg tgtgaatgcc aaacagagtg atgccctcca    72660

cccctgggcc tgccctggtc tcaatccaga gatctcttta ctcagagcac ctgcccagca    72720

gtcagcaaaa acgtcggagc tagaaagccc catggagtca ctaagaccca cacacacagg    72780

actgccatca gcagccccac tctgggcagc aaacatttca tcaggagccc gaagttgcca    72840

actggctgcc caggtccagc aggccctgtc tttgtcaaac ccacagttgt ggtcaagagc    72900

acctcttcct cccctctgtt ttcttgattt acctgggccc tcgccaaaca aagtgcacat    72960

ccttggtact ctgcagcaac aaatggtgga ttacgcaaac caccgtcaga cttgccaagg    73020

gcccctggct gaggatgaca cccacctagg agagctacag cagacaatgg gtcgcagctg    73080

caggggagac accagccagg agtgagccca ggtcagtgtc agggtctccc cagcctagga    73140

gtgcccacag ctctgcccca cacctcccag gctctaaccc tatgcctagg cacctgtgca    73200

atgcaattac ctcctatcct taaagagacg gcagcttctc tgcacctctg tgaagcagag    73260

ggtttcaggg gggtgattcg caggggagca ccctgggggt ttcttatgac tcgaattgct    73320

tggcccaccc ccgattcatc aggtctgggt gagccagaga atgtacattt ttaacaagtt    73380

tgggaaccac tacggtaggt tatgagcctg ctctggaact tcactgcctg agttagacga    73440

gttatctcac ctcccagagc ctcatgtcct ctcctgcccc gggcagctcc cagtggtgcc    73500

cactgcccag gctcctgtgt ggctcaggcg caattttgcc caccaaatcc tcccagaagc    73560

acatcatgag tgccccaggg cgttaattaa tgtggtgcag cccctcaaat aaccctgagg    73620

agaaatgaaa aagcaacata tattttcctt taaaatggaa taaaatcatt ccagtttctg    73680

gggttgccaa gtaatgagag ggaaaccaaa gaggacaggc gtcagattgc agatcagtcc    73740

tggctgtggg ttggttgtca ccttggattg gaacatactc gcccccagct ctgagcctgt    73800

actcagtgac tgcaatactg tggagccctg tagcccggtg aaaagagatg aaaaggcctt    73860

cggttatttt tcagttaact taaagagcaa gatgtacttg gggtgaccag agctttctgg    73920

ttttctgttt tccctgcacc atcctgcata aagggatctg tgatttaatg acagtggggg    73980

cagggaggtc aacccgttgc cctgccgtaa cagagaggaa gatagggtcc agcatcaggc    74040

ttggatttca ttacaagtta tcacccctgg gaaagtgtcc tcatctgcaa aatggggaca    74100

tgattgttgg gaggaaagat gtgatgacgt gggcgatgca tgtggagtgc ttactccagt    74160

gccaggcgcc aggcactgac cagagatgaa gcatcccagc ccagcaggcg gcatggctcc    74220

acggcacgtg agctggcctg cacttccctc actgactggc ggtgtggaca gcacacagaa    74280

ggggaaagag attcagatga ggactcaggt gtctctgtga ctggccatgt ggacatggtg    74340

ccacttgctc agctgcagaa ggcagaggca agagggtgct tggtggggag gtagagggag    74400

gatgaaggct gtgtgtgtgg aatttgaggg gactgtggga catccagacc aagatagcta    74460

acccagagat ggcctgaagc tccaggcgga gagatccagg gctgggaagt cagctacgca    74520

ctcagggtgc cgggagccac tgggcagaag ggctccccat gaggcagctt cgtagtgcgg    74580

ggagagggca ggtgccccac ggagcctcgc tgacctacac tgccggctct ggcccggcta    74640

cagttcaaac ccgagaaggc accccagagc ctgggacact gggcagcaga aatccttccc    74700

tagaaaagca gtcagggcca ggcgcagtgg ctcacacctg aaatctcagc actctgggag    74760

gcctaagcag gcagatcatc taaggttggg agttcaagat cagcctggcc aacatggaga    74820

aaacccgtct ctactaaaaa tacaaaatta gctgggcgtg gtggtgcctg cctgtaatcc    74880

cagctactcg ggaggctgag gcaggagaat cactggaacc tgggagatgg aggttgcggt    74940

gaactgagat tgcgccattg cactccagcc tgggcaacaa gagcgaaact ccgcctctaa    75000

ataaataaat aaataaaaag cggtcagagg gttaatgaaa gaacgcaata gcctggcagc    75060

tgttttctta tcatcagtga cgaagtcccc tcaggcaaat ccagagcagg ctggcctttt    75120

ggagaaatct ctgctactct gcgtactccc gtggtttccg tctcttgtgc ccggatgctc    75180

ttccgtgaca ctaaacagca agcactgccc ctcaggtgtg aagcgggcct cccagcctcc    75240

cagacaccgg cgctcagttg ctcctggctc agagcctctc agacctgact gcacacacat    75300

ctccagggac ccgctgagca atggattctg acacagcggg tcccagtggg cccgagactc    75360

agcatttcta gcaggttccc aggggacccc actttgagca gctagagagt ctctgcgagt    75420

ctgcccacag ttcagaatct gccactgggg gtacacagcc agtgccacag tctgggaccc    75480

cttgttgaca gctctaagaa tcaacaaaca gatcattcct aaaaatgcaa tcttttaccc    75540

tctgcagaga atcccagcca gcctctaatg catactggtg agattctaaa ttgtgtggat    75600

taacagacct caaagacccc catatgagct attgtggctg taaatggagg cgtagctccc    75660

tccagccatg tgcttctggc tcactgagca ttcctgggga aggggaacac agtgcccggc    75720

aggaccctcc ccggagtcac cactgcctcg aactccacgc gaggtaggca gaaccagtcc    75780

ccgctcattt tcactttaaa ataggccttg tgaggacatt tttgcctgtt ttgtggaact    75840

gcagttcata ccagctttta tcaaacaccc cagccttgct tattcgaaac tcaggtgcac    75900

acggaagtgt acaaggggag atggacccgc agttggccac ccaacagaaa cccacctgga    75960

gcaccttgca cttaacaagc atcccaagag gcagatgaac cgaaacacac agcacacagt    76020

ggaccggggt gaaacctcca gacactgtat atttggttag tgcagagtta atcctcagta    76080

gacaggcata gaccctggcc caggagaact tgggtgcagg tgcagggggt gccggtgcct    76140

atcctggggg ctgcacaggg ctgcatctcc accagggctc gcgccccacc ctggtttgtc    76200

tgtggacccc cagctggtga cagtggaagg agtggacatg gtgggaagag gatcagccca    76260

gaccgctctc ttttcctttt aatattctgg gttttgccca aacctctttt agacatcacg    76320

tgcattcaac atgatgctgg tgcgctaata atataaaaat gcatacttgt atgattctgg    76380

gatggatttt tttcaagcat ttaggggtaa tgcagagtag gtgcttgttt tccatggcaa    76440

tttttctgac tcgcctggaa aacagcagac ccacccaggg ctgattatcc aacctctgct    76500

tcaggctctg caggtgcctt cattagctgc cctcaaacca cacccattgc tgcccaaggt    76560

tggcactttg ggaccggatc tgctcacctg ttcttgtggg ttatatgtgt agtgacagtg    76620

gcagcaagca gaggtgagac acttgtgtgg ggggctgacc tcaccctcat gaggtcagcc    76680

ctgcagccag ggatggcaag gcccaccgcc tcccgtttga cccccctcta gtcttagcat    76740

accttctgtc ttgcccgggg gcagaggcac tgaattgtgg acaaaaaaga ccaagtaagc    76800

tagatgcttg ttcttctttc aattgataca taataattgc acatgtttat ggggtacaga    76860

gtgaaatttc catacatgta tacaaagtgt catgatctga tcagggtaat tatgatatcc    76920

atgacctcaa acgtttatca cttctttgtg ttgggaacac tgcaaatcct ctcttgtagc    76980

tgtgagaaat atacaatgca ttattgtccg ctgtagtcac cctgcagcgt gccagagctc    77040

agaacaactc ctcctgcccg gctggacttt tgtatttgtt aaccagcccc tccttcccca    77100

cctctgttct gctccacttc tatgagatcc actcctttgg cttccacacg agccgcgcgt    77160

tgcttttatg aaacagctgt gcttggggca gatccatttc cttttttgcc acaagcacct    77220

tccctcgcct gtcggccacg gagctgtgac tctgaaaatt ctggcacacc cttgccttta    77280

tctgtggttt gagggtcttt gctcctctcc cttctgctga aaaggcagct ccattcctta    77340

ttgccgagct ccgagcgcag ggaagaggcc cattgtcagg aagtgagctg ctgccctttg    77400

gtggcctggg tggcctgtgg gcaagtctga atccccatgt cctcctgctc cttgggcaat    77460

gatctagtga ctgtgattct cctgaccagt cttgtgagaa gtgtctccct gcagatgctc    77520

tagtggccct gggaactttg gaacgtgagg gggcttgtgg ggtctggctg attgggtgct    77580

ggctttcagc ttcagtcctg acacgagagg ctgagctctg gagaaatgtc agggtccacc    77640

atcccaccca tcttgccccc acctcctcgg ctgcgcacac gtgctcagag caagcatttc    77700

tctcaccaac tcagggatcc ctgcacacca gggagcaccc agcctacacc tgcagcctgg    77760

cacagttggg gaccgtttag ttggtgccag ctggaggtgt ttggagggaa ccatccggtg    77820

atcaggatag aggcacagct ggccgagggc aggtgggcgc ctgtgggtgc aggaagatgt    77880

cacatctgca ggcattgttt ggggacgtca ttgtgtaacc agccctgcag ggctgcagag    77940

gcatcccaca agtctgtgtg ctctctaggc tgcgtttatt gccccactct agaccacagg    78000

cctgggcata tttgtgtccc catccccaac cctgtcacct gaagcagcct gcgagccccg    78060

acaggaaggg acaagaagag gcgaagatga caaacattca cagacagccc acggctgttc    78120

ttttgctctg acagtgtatc ttaagctccc ttgagcgcct tactgaacag atagatcagc    78180

ttcttttcaa tctcttgttt gctcttataa aggaaattag gtcatgctgg aaactatgcc    78240

atgatgcccc tatgctcact cacctgatga agtgtgggag gctacccccc agcaaacaga    78300

aatgggcaca caatctgaag cctccttatc acactggaga cttccagagc aacttcagta    78360

aggtctgtga gggggaacgc tctgttgttt gacatgggct tgtggctttc agctaggggc    78420

acgcacttct ccaccagctc tttttttatt tttatttatt ttttattttt tttttgagat    78480

ggagtttcgc tcttgttgcc cagcatggag tgcaatggcg tggtctcgac tcactgcaac    78540

ctccgcctcc cgggttccag cgattctctt gcctcagcct ccccagtagc tgggattaca    78600

ggcacctgcc accaggccca gctaattttt gtacttttag tagagttggg gtttcaccat    78660

gttggccagg gtggtctcaa actcctctta ggtgatcctc ccgcctcggc ctcccaaagt    78720

gctgggatta taggcatgag ccaccgtgcc tgggcagctc tttccctaat aagaacactg    78780

gttctgaggc caagtaagag gctaaattaa gaaagcaaag atttatcata agtttgaggc    78840

ccacgaggaa aaaagcctcc attcatcatc cagaaacaca aggaaacatc atttgcccct    78900

cagtggacag gtgatgtttc ttacataccc tatgacatag ctgccctggt ccctcccaag    78960

cccaatgttt cattggccaa gcttccaatt tgctttacaa ggtgtgagga cagagaagca    79020

tccagcccat tctcctgtgg ccctgctcca tttagagcag acacgagtgg atagctcagc    79080

tggtcactag ctcctgggct gcccccactc acagaacaag agtgtgcgtt tctcctgaga    79140

acttcctact aaagaaaaca gccagcccag gcatggatta caggctcaca cctgtaatcc    79200

cagcactttg ggaggccaag gcaggtggat cacttgaggt caggagttca agaccagcct    79260

ggccaacgtg catttttctc tataaaaaat acaaaaagta ggtgtggtgg cacacacctg    79320

tactcccagc atctcaggag gctgaggtgg gaggatcact tgagcccagg aggcagaggt    79380

tgcagtgagc caagatcgtg ccactgcact ccagcctggg tgacagagtg agaccttgtc    79440

tcaaacaaaa cagaaaaaca gtccaactag gaagcttgct tctcccggaa gccttgctgc    79500

atgggctgac caggcacagt gctgggccat tccactgggc tgggccaggc tggggaggta    79560

ccttgatttg gggatggcag ctggccttgt ccttgactca ggggctgctt ttctgtagac    79620

caagtgcact tcacggattt ctccagaact ggtagagaca aaagtgagag agtgggagat    79680

gcatttgaag catgttggct ttattatttg caaaactgaa gtctggccca aaagaaggtt    79740

gatcttcttt taggaggtct ggaacaggac gtggtctctt ctgtggtgga atgtttttgt    79800

tttggctgaa tggttgcgtc ttagtgattt gactgagagc aaaatcagct tccattttat    79860

ccccgctaag tcacactttt tccatagaag gggagttgtg ggaagcatag ctttaaggga    79920

aggcaaagca caccttgctc tgaaactctt tggtcacaac catgtaaaaa catgtctgag    79980

gaaaaatcct aggcagaaat acagcaaaag tccacttagc caaggaggcc atgggtagtt    80040

cttttcctcc tttcttgtgt tcttattttt ccagattttt atttttattt tatttttatt    80100

ttattttttt ttgagacaaa gtttcacgtt tgttgcccag gctagagtgc agtggtgtga    80160

tctcggctca ctgcaacctc cacctcccgg gttcaagcga ttctcctacc tcagcctcct    80220

aagtagctgg gattacaggc atgcgccatc atgcctggct aattttttgt attcagtaga    80280

gatgcggttt caccaggttg gccaggctag tcttgaactc ctgacctcaa gtgatccacc    80340

caccttggcc tcccaaagtg ctgggattat aggcatgagc taccgcgccc ggcccctttt    80400

ctagattttt tttttttttt tttgagacgg aatcgcactg tgtcacccag gctggagtgc    80460

agtggcgcaa tctcagctca ctgcaagctc cgcctcctgg gttcacgcca ttctcctgcc    80520

tcagcctccc gagtagctgg gactacaggc gcctgccacc acgcccggct aattttttgt    80580

atttttagta gagacggggt ttccctgtgt tagccaggat gatcttgatc tcctgacctc    80640

gtgatccgcc acctcttgtc cttctaacaa gaagaactca tacccatact acgtaaagat    80700

agctatcgca tacactttta tcaccagcct ccttcccaca acaatattta tatgtataaa    80760

tcaagaagct attatttcaa actgatgctg aacaacaatc ccaaagtgct gggattacag    80820

gcgtgagcca ccatgcctgg cccccttttc cagattttta atagtgagca tatattactt    80880

ttatgactgg aaaaagtatt aacacattcc tactctatgt aattgaagga attagtcaag    80940

tattgtatca ccctaatagt actttcatgt acacactcta tgttgcttat ttttatggat    81000

ttcatatact ttgtctccac gcataggaaa attgagttgg tgaggcttgc aaaactcccc    81060

aacccacact gtttagtttt agcagactta tcacatgagt gttttcattt aaagaacaat    81120

aaccagccgg gcgcggtggc tcatgcctgt aatcccagca ctttgggagg ccgaggcggg    81180

cagatcacaa ggtcaggaga tcgagcccat cctggctaac atggtgaaac cccgtctcta    81240

ctaaaaatac aaaaaaatta gccaggtgtg gtggtgggtg cctgtagtcc cagttacttg    81300

ggaggctgag acaggagaat ggcgtcaacc agggaggcag agcttgcagt gagccgagat    81360

cacgccactg cactgtagcc tgggcaacag agcaagactc cgtctcacca aaaaaaaaaa    81420

aaaagaacaa taacgatgac tctttagggt tcattaaaca gtctaagaaa tacaaatatt    81480

tagctcccct cagccatcac tgcctcaggc ccattcatga tcatgaatcc agatccatga    81540

gctctgtggc agcgtctttg aaggtggagc ttctctggat catttgaggg actctatttt    81600

ccttgcaggt gtgggagcca cttcaggagc ttctgccaac ttccctggca cctcgggcag    81660

cagcaccctg tctcccttcc agcacgccca caaaggtgag gagggtgctc aggtatcgat    81720

cacctggagt taggtggtac tcggatgaaa gctcagaaga ggagaggaaa tgatcatgag    81780

tgatgattat ggtgcgcttc cccacctggc ctcacctccc taatgtaatt gaatgacatg    81840

ttgccccccg tgcaggaagt cattatatct gcaatcagag ttgatccctc tatgggtgtc    81900

ctgggaccgc tgggaggtgc tggtggtgaa ggcgggggca tagcggcagg tggacagcac    81960

aggcagctgc aagcccggcc aggaggagag accaggcgtc ctgggctttg gtttggccgg    82020

gagttaacag caattctatc actggttttc atataaacat gctgaccata gcactttaat    82080

attaacttgc agaatgtaca tttcattctc cctaaccagg gaagaaggga ttgaggagga    82140

ccccaaagtt taatatgtct ctcagagtca gccctccagc tggcttggcc tttctctctc    82200

actggtttag tgccagccca ttattgaagc atgtttcggg cccaggtctc agcgagccgt    82260

gaggtaccct ccagagccct cagagcaccc agctcgtcag cttcatctct gggcctccca    82320

cgcgctaacg cagagcaaaa ggcaggactg ctgggcgagg atatatgaat ctcatttgca    82380

caggccccgg ggggagtagc tcaaaacacg gagaatatta aaacacttat gtcatccaga    82440

cctggcatgc taacgctatt acaggtattc cccagatgat gctgggaggc tggttttcct    82500

gcagatgcac ccacagggga ggctcagcgc ccacatgcgg ggttctcagc tctggcacta    82560

cctcccccga gatgatttgg gagcttcaga tgctggtctc ctgtctattt gggtggtggc    82620

aaatctggat cttagttcaa gacaatcaga gtcctgtttg gttattttag agaatgagaa    82680

tgagcttcag ggcattttat gcatccaggg tcgacattaa cctgggaact gagcaaaatc    82740

ccccggggtg actgagggac tgcctggtgg aggcggcagt gcaggtggaa taggtggccc    82800

agccgaggca ccccctgtgc cctggggctc ttacaatgac acttaggttg aaattgcatg    82860

aggtgcaaga tggagccaaa cctggaatcc agagctgact ttcgcatcct gacttttgtt    82920

tggaaatgcc caaacttgaa ttgtgctgcc ttccagccac tcttgttcac tggcctttct    82980

tcctctccac accaaaccct gccctcaggt tgccaaagca gtagaagcaa gagcaaactc    83040

cctaggaaca atcaggtgac cccagagaag tctggagagg ccagtctgag ggcagcgagc    83100

agggctgtgg gcagtcctgg tctggcagcc aaaaccagcg cggaggattt ggttctcagt    83160

ctaagcaagc acctcagatt tcagggttcc ctgaaagcat cccaggggca gggccattgc    83220

ttccaggggc cggagtcctg gagggaagac cagcagggat cctgagctct gggtcattca    83280

tgccttctct ccacccacag aactctcagg ccaaggacac ctggccactg ccctgatcat    83340

tgcaatgtcc accatcttca tcatggccat cgccatcgtc ctcatcatca tgttctacat    83400

cctgaagaca aagccctctg ccccaggtga cggcccccat gcgccggtgc cctgcttcct    83460

ggactctccg tcaactcccc ctgtcggaga gcctggctgc tcactccctc ctctctcccc    83520

agcctgttgc accagccacc cggggaagag cgtggaggcc caagtgagca aggacgagga    83580

gaagaaagag gccccaggtc tgtgaaccag ggcttccaca caccatgtgc acggtgccca    83640

tctctgggtg gagggcgttc ccagaagcag cctcctcgct gcttctgctc tcacatgctg    83700

aaccatactg tgcttaccgt ggggtggtgc cacacagaca ccgggcagct ctgcccaaca    83760

ggaagagcag ggttgggctg agcgcagagc catgagccaa ttctaactcc tatctcccca    83820

acctccccat ttccctgcag acaacgtggt gatgttctcc gagaaggatg aatttgagaa    83880

gctgacagca actccagcaa agcccaccaa gaggtatgtg gaagccccca gcaccaagct    83940

gaagctgggg tcctgtggat cctgagcagg gaggggaacc agggtgcagc cgagtgaact    84000

gacaggctag cctgggacac tatggggacg ttcggcgaca gacagtcccc accacctctt    84060

tgctgactgg caggggtcag gtggtgtgag gagcctgtgg aaacagctgc ctgctgctct    84120

cgggtcaggc ccctgtccct gcatcctgcc aaattccctg ggccttcctc cttaacatcc    84180

gaattcctca tgccccttct ccagactggg agggcagaac ataaagccaa ggatgcatgc    84240

ctgttgcggc caacacacca gtaccacccg tgccggtgcc agtactgctg ccaccgtaat    84300

gctggtaaca accgtggtga tgacggctaa cagcatttgg tgcctactgc ccaccaagtg    84360

ctgggctagg gctgtgaaca catcctccct ccacagccca ggagcaaggt gcttgtatca    84420

tccctgttta taggatacca cactgaggta tggaagttgt cactcgccca aggtcacaca    84480

ctagtgaaca gcagggctgg ggtccgagtc caggctccca aggagccaca tggtgtaaag    84540

aggcctctgg aggaggagat ttggcaggtg aagcctttcc cgcgtttacc acacatgaag    84600

gtgtggaacc agcccctgct ctaaaatcga gggtagaggg aagtcaatat tttattcatc    84660

cagtgggatg gtcatttgga cttggtcctg cgtagcttcc aaaaatcaac cccacagcat    84720

cagctcccag ccaggcaatg tgctcggacc cccctgccag gcctctgccc gacagccact    84780

gcaggctgcg cctggaagga cacccccgca acagtgcctc ccttggcaga tggggcacag    84840

aggccaccag aaggtcacca aactggttac aggaagagca gaggttaagc cctcctctcc    84900

tgcccccacc ccatgatctt cctatgattc accttgcaaa gccattccaa tcgatccagc    84960

atctgtgtgg agatcctgtg tgccagatcc aagctgctgc tcccaggacc aagggcagga    85020

cctggtcacc ctgcatggaa ctcttaaata gggcctccct agagactgaa tttgctcctc    85080

agcctccagc ccagccttat ctcattctgt ctcagcctct cccttctgat attcaggctt    85140

ttcttattcc cagaaatcaa aaaggcagag acgtgcccca tgacttgagt tgcagttgaa    85200

gacagggaaa atttggaggc cctattagga aaaaatatat actgctttca tacacgaata    85260

ttaaatacaa attgaaccct gacacttgta cgttaaaaga cagcaaggca ctgagctttt    85320

gtccctgctg tttgtcctta ggtctcagag acaggacctg gggtgccacc tcacctgctc    85380

cacctcacct tctctcgagt ggggacaggg atgggtccta ccacctcctt gtgaggccct    85440

gaagcctgat gaggaagtgg gtcccactgg ggcttcatga tggttctcat tgtctttgta    85500

ttaccctgtc tctagggttg tgtttgcata tgggcttcac tgctgtaacc tagttactaa    85560

caaatataat ccttttttta agaaaaaaag gtcttcagcc aaaccacagg aagcaagcag    85620

gatgcctcta aaaaagaata ttgtttttca tatacttgga atggttttaa gagagtttaa    85680

gctccaaccc acatgtgcct agggcagacc ctgggttctt tgtgggctgt gagccacagg    85740

gcggcatgaa cctgggcttg gtgggtccga ccgcccaccc agctcacccg ctggggcttg    85800

ctgtgccacc ccctgcaatg cacacaggtc agccaggtca cccccctagt caagaggggg    85860

ctttccaggc acaaggctcc attcagctcc cttttcaatg actccagaga gccagcatgg    85920

attcagcgcc agctgcatca atctgtttgc ttaacatgaa gacaccagtt gaacttggtg    85980

cttactggga ttaaatacag agatctagga catattcaat gaaccttcac ggagcatcca    86040

ttgtgtgtca ggtagcaggg aaggagaggc ccgtggatgc ctcccacacg cagtggcagc    86100

cccagcccct tagacgcctg caggtcaccc accacggact tgtttgtttg gaaagaagca    86160

ggaagccacc ggtgtatgtc tcgtctcatg tcccctggtc ccgtgcccac aaggtgccca    86220

gtaaacacct gaaaaacaag tcattgcccc ccactgtcca cagctgggca atggacaagt    86280

tcaccacagg agaacttgtc agggctgcag cccccccagg cactgctaat gaccatcgct    86340

cttgtttttg cagcgagaac gatgcctcat ccgagaatga gcagctgctg agccggagcg    86400

tcgacagtga tgaggagccc gcccctgaca agcagggctc cccggagctg tgcctgctgt    86460

cgctggttca cctggccagg gagaagtctg ccaccagcaa caagtcagcc ggggtgaggc    86520

tcctgcaggt gccatgatga gctgtgagat gtggctccct cacagccgca agactaaaac    86580

tttcttattg aatcagctct cctgcaagac ggggtgtttc tcccagaagt ccaagatagg    86640

agacctggac agtgacaagt tcacagcaag atagtcaaaa gggaaaaaaa ccctttcgtt    86700

tttgagtttt gttttttttt tttggagatg agagtcttgc tctgtcaccc agcctggagt    86760

gcagtggtgc gatctcggct cactacaacc tccgcctcct gggttcaagc aattctcctg    86820

tctcagcctc ccaagtagct aggactacag gtgcacgctg ccacacccag ctaatttttt    86880

ttatatttta gtagagacga ggtttcactg tgttgcccag gctgctctca aactcctgag    86940

ttcaggcaat ccacccgcct cggccttcca aagcactagg attacaggtg tgagctacca    87000

cgcccagcca ctttgttttt attatatagc ttcatacaca aaaacgaaaa ataataagca    87060

aggagaaaaa aggtaaaatc acttggaatg ccagagggca gaaaaagacc cttgtaaata    87120

tacggggttt tatctaacca gacaattttc tagacacaca cacacacaac gtttttcttc    87180

tatgcatttt taaaaatata aaaacaggtt cacatgtaga aactgtcccc agggttttat    87240

cacctaccgc cctgtaatgt gctgtggcca ggagcagggc aggggtgagg gcaaaggtgg    87300

ccagagccct cttgggctcc ctgtagacct ggcctgtggt cgtccctcta gcctgtgccc    87360

ctggctgcag gccccagccg caggacagct gtgttgctag gcaacatcac tgatggcaaa    87420

aatgcccagt tgggatcctg gctccagcct ggtcctgata ggatgccaag ctctgcctgc    87480

cccgagttca gtgacctctg taatggggct gccacttgca gagaccctgg aagcctgtgg    87540

ggttgttaca agggagatag gtggccatgg ccccgggact cttcagccag ggccactgag    87600

cagctgtgca ccgtgggcct ggtctcctgg caccagccac gtgatccggg atgggagccc    87660

cgcacggctc tgctgcagca cagatgtcct gagggcaagt gggggtcccc atggtcatct    87720

tttcaaacag actgatgcca ggggtgtccc caagtatctt acgagtctga ccacccagct    87780

gagcctaaga cgcacccgtg gtagacccca aaaatgtttg aataggaaaa cctgaagaag    87840

gccctcctcc ctgtgtgtca gggctgggct gctgacacgg gggctgtgtg cagcgtctct    87900

ggtgttgggc gtagctgctg cctgcccctg ctgacatgga ggatttgcct cctttctact    87960

gttgcccctt tctggagatg aaaattctcg actctttttc acagattcaa agccggagga    88020

aaaagatcct cgatgtgtat gccaacgtgt gtggagtcgt ggaaggtaag ctgaaaaaaa    88080

agcctgggag aggtggtgcc caccccaccg acatgaaggg ctgggcccgg agccctgagg    88140

ctcctgtgag gggaactgag ggaagccgcc catccagttg ccgcactttg gtcagaatgg    88200

ccgctggaaa ctatttcagg tgtggggaaa cagaatcttg ttcccagata tcggaaggca    88260

tctcccagtg cttccatggg ccttcccctc atggggcggg agacagcctg gtgcaggcac    88320

ccactgtagg gaaacgcagg gtcggtgagc agcagccacg gagcctcaga cctcccgtgt    88380

ccccagagac cgtgtccaca ctggcatcat catctgggaa acgtgatcag tcatttatcc    88440

tagacttagc tgccctctcc ctgccctcga gcatccccga tgtctgatag ccctgggagc    88500

ctccagcctc ccctcccagc ggccttctga gctaagtcag gctgtctccc cataacctgg    88560

gcttgagtgt gggcaggtta agaggcaaca ggataggacc gtcagtgctg caatctgaaa    88620

tcataatcct cagcttccag ttcctgcaaa atccactttc taaattacct tcttattaac    88680

cccaaagata aatccctcat ggctgaggtc aggggttttc ctgctgctgg actcgctggc    88740

ctccctccgt ggactccttg atctggccgg gcagcgggag tggagcctgg tgcatgctgg    88800

gcagctcacc aatgccccca ttacccctcc tcccaccccc acaccccacc gtaggccaaa    88860

tgcagccccc tgtgccctgg caggctttct gatccagtgc tttgttggcc agaaataact    88920

atactgtggg tgagttccag ggccaagaat tcttggctgc cgctgaaatg tggcatctct    88980

ccataaacgc atgccccagg tcagcctgcc tgatctcacc tggcatggcc tggggctgtc    89040

agctgcccag gggaggatgg tctaggactc accttccatc caccaggaag ctcttctctg    89100

ttccaaaaaa tgttgagttc acacccctgg gacagaggtt ttcaaacctc agccagggct    89160

gagaacctgt gctccatgcc cagctctgat gaacattaga gtcacctgca ggtcttaaca    89220

ccctctctgc ccatccagcc cacccaatct gcccaaacac cctgatgtaa ttagtcaggg    89280

gtgaatccca ggcatctgtg tctctttgtt ttttgttttg ttttgtcttt aattaaactt    89340

tttattttga gatacttctt accatgcagt ggtaagagat aatacagaga gatcctacat    89400

gccctttacc cagtttctcc taacgataac atcttgcaaa actatacaca gaagtcacaa    89460

ccaggacact gatattgaca cagtgatatc gactcagctc ccatacaaaa actcctcctg    89520

ttgcctttta tagccacagc caatttccac ccaccccacc ctcacctagg cccctggaaa    89580

ccagtaatct gttctccatt cctataattt tgtcatttca agagtgttat aaaagtggaa    89640

tcacaaggta tgtaaccgtg gtgaatggct tttttcactc agcataattc actggaggtc    89700

catccaggtt gttgcatgta tcaatagtcc attcctctct cttgctgagt agtagtctgt    89760

ggcataaatg gaccagagtt ggtttaacca ttcacttgtt gaaggacatc agggttattt    89820

ccacttaacg gctattatga ataaaggtgc tataaatatt tgtgtatagg tttttgtgtg    89880

gacatcagtc gtgatttatc tgggataaag acccaggagt acatttgttg ggttgtatga    89940

tagttgcatg gttgattatt ttaaaaaact gccaaaccgt tttctaaagt tattgtacca    90000

ttttacattc ctactagcag tgtgggaacg gtctagtttc tccatatgct tgccagcatt    90060

tggtggtgtt actatgtttt gttttagcta ttctgagaag tgtgttatga tatcttattg    90120

tggtctcaat ttgcatgttc ctattgttta aatatgtttt cttgtgtttt tttcatctgt    90180

gtgtcctctt cagtaaaatg aatgtttctt catgtctttt gcccattttt caatggtatc    90240

gtatgatttt tttgctgttg agttttgagg gtttttaaaa atatattcta gacactagtc    90300

ctatgatgga tatgtggttt tataaatgtt ttctccattc tatagtttag cttatctttt    90360

cagtctctta acagggtctt tcatagaatg atgttttaaa tttttatgag tcaaatttat    90420

gaaactaatt ataaagtttt ctttttatgg atgatgcttt tgtgtcaaat ctaagatctc    90480

tcttgcctag tcctagatcc cagagatttg ctcccacaat tttttctaga agttttatag    90540

cttaatgttt tacattctaa gtccacatag tttttatgtt ttacatttaa gttcacatag    90600

ttttatattt tgcatttaag tttgagttga tttttataga agatatgaaa cttgggtcaa    90660

agttcatttt tttgtctatg gatgtccaat tgctccagca ccattttttt gaaaaattat    90720

ctttcctcca ttgaattgct tttcaaactt tgtcaaaaat cagtttggca tatttgtata    90780

ggtctatttt ctggggttgc tgttctgttg catttatcta catgtctgtc cctctgataa    90840

taccacaagg tcttgattct tgtataaatt atgtaataac atataagtcc tgaaatcaaa    90900

tggactgctc ccattttcct ttattttttt ttcaaaaatc ttttagctat tctagttcct    90960

ttgcctttcc atataagttt tataataatc ttccctatat gtacaaaatg ccttgctggg    91020

attttaatga gttgcaacaa aactgtatat caatctggga agatttgaca tctttattat    91080

gtcgagtctt ctgagccatg ggcatggtat atctcttcat ttatttagca caactttaat    91140

tttttttcat ctgcattgtg tagcttccga aatacaagtt ctgtgcatat tttgttagat    91200

ttacaccata tcatttattt tttgagccac tgtaaacgac aatttaaatt cagtagccat    91260

acattcattg ttagttatat agaaatacaa ttgatttttg tatgtttatc ctgtatcctg    91320

tgaccttgct gaattcactt ataagatctg ggagttttct tgtagatgcc ttgggatttt    91380

ctacatagat aatcacatct gcaaatggga ccgttttatt tcttcctttc caatctgtgt    91440

accgtttctt tccttttctc attttattgc actggctata ccttccagca ctacagtgaa    91500

tataaatgat gaagcagaag cagaaatcct tgccttattt ctgatcttaa aagcattcca    91560

tttttcacca ttaagtataa tattagctct aggcttttta taaattgttg acattaattt    91620

tttgagtgga ttacaataat ttttaaatat tgaaccagcc ttgcctccct ggaataagcc    91680

atacctgatg tggtacaatt cttttttatg gttgcattct atttgctaat attttgttaa    91740

ggattttgca tttatattca tgagagatct tggtctttgg tttgtggttt gttttttgtc    91800

tttgtctggt tttggtatcc agtttatact accctcatag aataagttag gaagtgtttc    91860

ttccttttct atgtctagaa aagatcgtgt agaattgcta ttctttctta aacattttgt    91920

agaattcttc agtgaaatcg tgaggaccta gagatttctt ttggggaggt ttttttgttt    91980

tgttttgttt tgtttttgag atggagtctc gctatgtcac ccaggctgga gtgcagtggc    92040

acaatcctcg ctcactgcaa cctctgcctc tccagttcaa gtgattctct tgcctcagcc    92100

tcccaagtag ctgggattat aggcacatgc caccatggcc cagctaattt tttttttttt    92160

tttttgagac ggagtctcac tctgtcccag gctggcaacc tccacctccc aggtttaagc    92220

gattctcctt tctcagcctc ctgggtagct gggattacat gtgcatgcca ccatgcccag    92280

ctaatttttg tatttttagt agatatgggg tttcaccatg ttggccaggc tggtcttgaa    92340

ctcctgacct tgtggtccac ctgctttggc ctcccaaagt gctgggatta caggcttgag    92400

ccaccatgcc cagccctaat ttttgtattt tagtagaaat gaggtttcac catcttggcc    92460

agactggtct tgaactcctg acctcaagca atatacccac ctcggcctcc caaagtgctg    92520

ggattacagg cgtgagccac cgcgtttggc tagatatttt tacagttaca aattcagctt    92580

ccttaatagt tataagtctg ttcaaatgat ctattttata ttgggtaagt tgtgatagtt    92640

tatgtttttt gaggaattgt ttattttcat ctaagttatc aaatttatat gtgtagagtt    92700

aaagttgcaa gttttatctt attatctgtt tgatatctat ggtgtgtata gtgatatctc    92760

ctgcttcatt cttgatattg gtaatttgtg tcttctctat tttttccttg tcagttatat    92820

tgatcttttc aaataactgt ctcttttcat attgatctct tttactttat agttttcaat    92880

ttcattgatt actgctctta tttctaaatt acttatttcc ttctatgtac atttggttta    92940

ttttgttaat ctttttctaa gtgcttgaaa tgggagctta gattgttaac ttgagttttc    93000

ctcctttgta tgtatctgtc ctataaattt cactctcagt actactttag ctgtgtctca    93060

caaatattga catcttgtat ttttattttc attcattttt aaattgtctt tgagacttcc    93120

tctttgacct gtggattatt tagaagactg ttgtctggtt ttcaagtgtg tgaagatttt    93180

tctgttatat atttatattc tgattctatt gtggtagggg aatatccttt gtataatttc    93240

aattctttta atttgttgag gtttaaggcc aataattatg aacaatgtgt attctgctgt    93300

tgttgaatgg agtgttctat aaatgttgat tagatcgtgt tggttgatga tgttggtaag    93360

ttctatattc ttgatttttt ttctaattgt tctatcattt actgagggag gaatgttaaa    93420

gtcttcaact ataattgtgg acttatctct tctttcaggt ctatcagttt ttgtttcaca    93480

tattttggag ctctgttgtt tggtgcatat tcatttagga ttgctatgtc ttcttggatt    93540

gaccctttaa tcattattaa atgtcacttt ctggtaattt tttcctctga agtctacttt    93600

aactgatgtt atagccactc tgccttcttg ttattgaagt ttgcatgata tgtatttttc    93660

catcctttac ttccaacgcc tctctcatta tattgaagtg agtttcttct aggcagcata    93720

taactgggaa aatttttaag tctactctac caagctctac cttttagttt ttttgttttg    93780

gtttggtttg ggttttttgt tttttttttt ttcttttttt ttggagtttc cactcctgtt    93840

gcccaggctg gagtgcaatg gcatgatctt ggctcactgc aacctctgcc tcccaggttc    93900

aagtggttct cctgcctcag cctcccaagt agttgggatc acaggcatgt gccaccacac    93960

cagctaattt tgtatattta gtagaaacag ggtttcaccg tgttgaccag gctggtctag    94020

aactcctgac ctcagctaat ccatctgcct tggcctccca aagtgctggg attacaggca    94080

tgagccacca ggcccagcct ttagttggta tttaaaccat ttacattaaa tgtagtcatt    94140

gttagggctt aagtctgcta ttttatattt tgtttactgt ttgttgtctc tgtttttcat    94200

ttctgtgttt ttttattcct gctttactgt gggtcacttg aacatatttc agaattcgat    94260

tttggtgttt tttgagtgat acattttgat tttatctctt tccatagtta ttttagtagt    94320

ttctctagac attgcattga cacatataac ttatcagtct actggtgtta ttattattat    94380

tatttttgac atggagtttt actctgccac ccaggttgga gagcagtgac acgatctcgg    94440

ctcactgcaa cctccgcctc ccaggttcaa gcgattctcc tgcctcagcc tcccgagtag    94500

ctgggattac aggtgtgcac taccacgcca atgtgttttt tgtgttttta gtagagacgg    94560

ggtttcacca tgttggccag gctagtcttg aactcctgac ctcaggtgat ctgcccacct    94620

tggcctcccg aagtgcttgg attataggtg tgagccaccg tgcccagcct tactggtgtt    94680

attattttgc cagtttgaat gaagtataaa aaccttacct ttctctatgt ccctttacct    94740

tctctgttta cagtagttgt aaatatttcc tctacatata tttagaacca cataaattgc    94800

ttcaactgcc taatgtaatt cagaaaactt aaaaagagaa ggaaagtcta ttgtatgtgc    94860

ccatattttt gctcactatg ttcttttctg atgtctcaag tttcattctt ttactatttc    94920

ctttctgttt atagaatttc cttttgcttc ttttaggata ggtctgctgg tgaaaaattc    94980

ttaacttttc tttggcttgg aatgtcttga tattctcatg ctttcctgaa ggatattttc    95040

actcagctca ctgcaacctg gtatgcaact ctgggttgaa agttcttttc tttcagtact    95100

tggaaatact gtgctacttc tctctggtct ccaggtttct gattataagt ctactgtcat    95160

tctaattctt ttccctctct aggtcaggcg ttgtttttct ttggctgttt ctaagacttt    95220

gtctttagtt ttcagaagtt catttatgat gtatcttgac atgaatatat ttgggtttat    95280

cctgtttggg atttgcttat cttcttgaat ctgtagactt acgtctcttt acaaatttgg    95340

agagttctaa accatcattt atttgagtat ttatttagtc ccactctctt ctcctctcct    95400

tctgaaactt cttgacacaa atgttagctc ttctgttata actccacagt tccctaaggc    95460

tctgtgtttt tcagtttatt ttctctgatt gagtaatttc cacttctagt ttccattatc    95520

catctcactg attctttcct ctgtcttact ctgtcattga gcacatctac tgagcttttt    95580

attgtggtta ttgtactttt gtagttctaa tattttcatt tcttttttac attttctatt    95640

atttttcctg aggatttcta tttttgcatt taagcatgtt cataattgct tgttgaagca    95700

cttttattat gaattcttta aaaccttttt cagattatct aacatctgtc atctcagtgt    95760

tagcatctat tgattttctt tttttactca tttgacatct tcttggttct tggtatgatg    95820

agtgaattca ctttgagacc tgtgtagttt tatgtcctga tatgaaactc tgggtcttat    95880

ttaagccttc tattttagct ggctcctttt gatagctctg tggcaggaga atgagggtgc    95940

tgtcttgcta ctgttgggtg aaggtagaca tccaaattcc ccactcaacc ttcactaaca    96000

ctcaaggggg attccttttt actgctactt ggggtttggg agtatggcta ctgacatggt    96060

caccacgggg gcagaggagt ttttaccagc tggttgatga gaaagcccca gctccctaca    96120

tggcctttcc tgacaccacc tggcacagtg ttacagcctg gtgagggtgg aattctaggc    96180

tccccactca gcctttgcta ccctggatag agtggggaca cagtttttct gtgatgtttg    96240

gctggaatag agcaattatt gtctaaatgt tttatgcttg ctaggctgct cttttcctag    96300

tgctctgact agagacagaa gacttttgtt ggggctgttt ttgtctgtgg ttgctattat    96360

ttccagattt ttggactttt ctgccccatg tctggaattt atgaggcaaa agaaaaccca    96420

gggaacttac caccatcacc atcctaaggt atcgaggtcc ctagttggtc tgtcttcttt    96480

tctccacttt tcagacttct tgtatttgtt ttacacagaa tgtccagggc ttttagctgt    96540

acttagtggg aggattaggg aaaattatat ctactcttat cttccagaaa cagcaatatc    96600

aagtttttaa atgctcctag gtgagtctaa tgtacagtga agcccaagaa ccatcagacc    96660

actgagttgg cagtgacttg gttcagataa ccccaatctg gggctatcat tgagagcagc    96720

catcacaaag ttgactactg ttccctaaag agacatgaca ctgtcccttt gaacccctcc    96780

tcagcccagc cccatgggag acagggttac ccaactaagg ataacttgtc ttgaagtctt    96840

tgagaactgc taaaaatggt catgagggaa ttattatcat tgtcaatata gcagtcattt    96900

tcctagtggg gaaggggcta ttaccggggt cagggtacat gcacagccct ctcttgtggc    96960

tggcagcgtt ctaggtgtcg tttgccttaa gttatgcatt tgttttaggt ggctttctgc    97020

atgttttata attttaaaaa aatttttttc aaataatttt tatttcattt aaataatttt    97080

tcagtgttga ccttctattg actgtgactt gcaacatcta actgtggcca ttggtgtctg    97140

taggtcttag ccccacggag ctgccatttg attgcctcga gaagactagc cgaatgctca    97200

gctccacgta caactctgag aaggctgttg tgaaaacgtg gcgccacctc gccgagagct    97260

tcggcctgaa gagggatgag attgggggca tgacagacgg catgcaactc tttgaccgca    97320

tcagcacggc aggctacagc atccctgagc tactcacaaa actggtgcag attgagcggc    97380

tggatgctgt ggagtccttg tgtgcagaca tactggagtg ggcgggggtt gtgccacctg    97440

cctcccagcc acatgctgca tcctgaaaag catgcctgtg ggctgtcctc ccaggacaag    97500

ccaaggagcc aacgagggct ctggagctgt gagtggtgcc aaaagactgc caagaatcaa    97560

ggcttttgtg atatgtcacc gtatgcctta ggatgttcaa ggagccagac gaaataaggc    97620

ctgtcttcca atttaaccaa agataaagga ctagagccgg gatactttca gatgctcgcc    97680

tgtacctcac caggcagagt aaatatctac tcactcatac agccagccca ccagcccacc    97740

attaactcac tgaacaatga gacaatgttg aggactcaaa tgaatcaaac cccgtgggaa    97800

tgacagaagt gaagaatctg gtccctgtct ttaaggagtt tgcactccag tagaagacag    97860

aaggaacgta tgtttacaaa ccacttcact ggaagacgtc aaacaagctg aatgaagggg    97920

cgcttagaaa acgttaatag aagttctaag cgggagatga ctccctactg ggatgatgaa    97980

ggatggcatc ctagtgaaga agcagctcaa acattttgat aaaatggcaa caaaatgcag    98040

acaccctgct ccaggtatta tttcaggttt agtacaagtc tgttaatacc ctatgtggtt    98100

tcattaggat aactttttac ctatccttga ggtcatccat attcttacag gccttccagt    98160

caataatgga agagctcact ctatacaaaa ccaatatgca aggcatgtgt ttgtccaagc    98220

aattggatgt gtgcagtagc caatttcatt tactgcatta ctctttggcc tgggaaccct    98280

gtggtctgca ctacatgtga atggccttcc acttcagtct taggcagatt tgacctttta    98340

ggggcagcaa tgctgaagga cacagcaatt taaattataa tgtgtcaggc tgtgttttca    98400

cttcaaacat gtatgagtag tcagctgtaa ttagagaaat gatgacttcc taagagttca    98460

gccacgcata attctagatt tcaagagcat ctaagacttg tggattagcc tcatggcatg    98520

agagtttcag actcagcctt ctgagccagt cagggaaagt ggagttctgc agcgcaaatg    98580

agagcctggg cttgatgtcg agggagctgg cttctagttg tgccaccttg ggccttgtct    98640

tttcctctct ctgcctcagt ttctcgtctg ccaatgagat gttagttagt gattctataa    98700

ttggggcagg tagggttcag gtgagcaaaa agaaagtgga gctataggaa atgccaggcc    98760

tttgaggtgc tctatggaag tcaacacagt gtggtttgtc catttaaatg ggaataaaaa    98820

cagaaaaact cagacttggc attttcacaa taactgcaat ggtttgacat aacatttata    98880

ggcagaaagt taataaactg gcattgttct tggcatatta ttgtactatc cctgtaactg    98940

ccaagagctc aggagccagg ctagtgatca caccaggggt tagagttcac tgctgaactc    99000

cctgatggca ggtctgtgtt tattactaca ttaaaacaaa gtctctgact tataaagcga    99060

ggttgtaaaa attacaagtt gcatgactga aaaaatgctt tagggggaaa atcagtcata    99120

tctttaacac caacaagcaa tttcccacca acgaatgtag tacatactgt gagaggatca    99180

taatgaggtc ctgaatattt aatatcatca tttactgtgt ctgtttgctg ctgtttttcg    99240

aacctatttg gtttaccctg caagctaaat actccacggc agagcttaat tatcctttta    99300

attcctcttt gaaatcctgt ggtgccccct tccccctgcc ttgtgatgat gatgagtgag    99360

tctcccctta attagactgc aaatgtcact tgtgatgagt gtgccattcc aggataacag    99420

cttgcaccct cctcagaatg ttttcagcga aagagtgggg tggctgttct ctgctcctgg    99480

tgctttggcc tcatttcaca ctattagaat tctggggctg taaggccagc cagtgtcagc    99540

tcatgttcca ttggctctcc acctgccatt tttagggagc tattccttat atagttacaa    99600

attcccttgt catttactta tttggaaaca tgggatttac tctgacaagc tttagcctat    99660

gttatgggat tcagaacaat gagatcataa taattctcac tgaccaaagc tgggactcca    99720

tcctgccatt tttgtgtgga gatattcata attctgcaat actttaaaac atttagaaaa    99780

caccccaggg taggtctgtg gcccttagac agtgaagtct taattgtcaa tattattttt    99840

gtctaattct gtatatatat aacttattat attttataat ctcaataaac acattaataa    99900

gatttataga ctaccgtaat gtgagctctc tttgtatttg gggtggtggg tcggggggtg    99960

agtggggaag gttctgattg ctctgttcct ggttattgcc ctatgtatga tgagactgta   100020

ggattgcaac cagctataaa caaagtgcct aaaatgttat ggcctgggac attcactagg   100080

cagaagcaaa cattacaaag agatcatgta aaaaccacct ggagcattgc tttccaagtt   100140

gccatcatta gctcataagg cattgtatca cttatctatt tctgtgtaac aaactgtctt   100200

gtcttaaaat tcaatggctt aaagcaacag tcatttatta tcatagctcg ggggttagta   100260

gggggtcagt cagctgactt aggttgggct cagttgaatg tgggtcaact ggggcctctg   100320

tctgttggaa taccttaact ggggcagctc tactccatca tctctgtcaa cctagataga   100380

taacagagag aggctctcta aaagaaagaa aatgatatgt attggggaat agggcattgc   100440

aatgggaata catgtgccat agtaaactat gcgtgttttt gaagaggtaa aggaagacaa   100500

tggttcttag aggaaaataa ggaggattac ataattattt tgagacaatt atccttggct   100560

acaaggataa taagggtggt gccagtccag ggttggacag ggagttgctg ggcagaggtc   100620

cttgcaggag tctttgtgtg tgtttaagat tgtcatggcc tttgtgcaag gttttcgttt   100680

tttcagtctt gtgatggctc ttgttatcag tgatttatgc agggagaacc cttctttcct   100740

ggccttccat gactctattt gtcagttttg ttttgttttt taagcacaag tgactccttt   100800

ataattctga caacttccac atttccccca tttgatcaag atctttatca gaaagcatcc   100860

ccagtgagtc atcccatatt attccttcgt gccaggatag acctgtccta ggtggctggt   100920

ctggtctcac attggaggga tttgatggtg actaggagtc agtgtcaaaa ccctttagcc   100980

atgtttgaac aaatgggaag tttggagaga gtggctctca ggctaggtct acttgaagtc   101040

tactgttaaa tttgattttg tctgttctgt aaacatttgc tatcatcatc tcaaaatgca   101100

gggccagtat tattctgtta gaaggtgtac ttctactgag atttgacaag taacaggaag   101160

tttaaaaaag gaaaatataa aggaaaatta aaatcaatag taatatgaga atcccagttt   101220

gcatgatgat tttgagccat gaatgtaggt ttaaaggcaa ccaaatgaat aaatgaaata   101280

accatgagga attaggtgac ccttctttta tccttgtggc ctctttcttt attttgtgaa   101340

catgggtctc aactttccca gaggaattta cctaggtaca gcaatgtagt attagaaata   101400

gcacagacaa agatggctac tagaagcatt tcatgccagc ctcttccact tagaacaaaa   101460

acagtgtgta gacagtcaca ctttgaatac attatccaag agagaacact ggaattcaac   101520

agagaagtgg caggaaacac caaaagcagg gaaggagaag ggagacaagc agcctgccta   101580

gccaggatca actaggagct gggagtgact tcccaattca gggaaagggt gaataagaga   101640

cttccagtgg cccagatccc cagcatgaac tcatgtaatc ctggccatga gagacccctc   101700

aaccctccca accactgaag ctaacatagg gagctgctgg gagaccatgg gatggaactg   101760

ctccagagat ggagtttgca ctggatccca cacctttctg agacctaagc aactacagca   101820

agacaccatt ttcaaaccta gccttgggta gattgcatgc tgtcctgggg cccagaggca   101880

ctgggactga ggtgttacag aa                                            101902


<210>  217
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  217
atgtgcaata ccaacatgtc tgtacctact gatggtgctg taaccacctc acagattcca       60

gcttcggaac aagagaccct ggttcttttt tatcttggcc agtatattat gactaaacga      120

ttatatgatg agaagcaaca acatattgta tattgttcaa atgatcttct aggagatttg      180

tttggcgtgc caagcttctc tgtgaaagag cacaggaaaa tatataccat gatctacagg      240

aacttggtag tagtcaatca gcaggaatca tcggactcag gtacatctgt gagtgagaac      300

aggtgtcacc ttgaaggtgg gagtgatcaa aaggaccttg tacaagagct tcaggaagag      360

aaaccttcat cttcacattt ggtttctaga ccatctacct catctagaag gagagcaatt      420

agtgagacag aagaaaattc agatgaatta tctggtgaac gacaaagaaa acgccacaaa      480

tctgatagta tttccctttc ctttgatgaa agcctggctc tgtgtgtaat aagggagata      540

tgttgtgaaa gaagcagtag cagtgaatct acagggacgc catcgaatcc ggatcttgat      600

gctggtgtaa gtgaacattc aggtgattgg ttggatcagg attcagtttc agatcagttt      660

agtgtagaat ttgaagttga atctctcgac tcagaagatt atagccttag tgaagaagga      720

caagaactct cagatgaaga tgatgaggta tatcaagtta ctgtgtatca ggcaggggag      780

agtgatacag attcatttga agaagatcct gaaatttcct tagctgacta ttggaaatgc      840

acttcatgca atgaaatgaa tccccccctt ccatcacatt gcaacagatg ttgggccctt      900

cgtgagaatt ggcttcctga agataaaggg aaagataaag gggaaatctc tgagaaagcc      960

aaactggaaa actcaacaca agctgaagag ggctttgatg ttcctgattg taaaaaaact     1020

atagtgaatg attccagaga gtcatgtgtt gaggaaaatg atgataaaat tacacaagct     1080

tcacaatcac aagaaagtga agactatttt cagccatcaa cttctagtag cattatttat     1140

agctgccaag aagatgtgaa agagtttgaa agggaagaaa cccaagacaa agaagagagt     1200

gtggaatcta gtttgcccct taatgccatt gaaccttgtg tgatttgtca aggtcgacct     1260

aaaaatggtt gcattgtcca tggcaaaaca ggacatctta tggcctgctt tacatgtgca     1320

aagaagctaa agaaaaggaa taagccctgc ccagtatgta gacaaccaat tcaaatgatt     1380

gtgctaactt atttccccta g                                               1401


<210>  218
<211>  826
<212>  DNA
<213>  Homo sapiens

<400>  218
agagcgtccc agcgcgcccg cctccccacg gacacagagc ctgctgccca cgtctcttcc       60

ctgagctgcc tgctggggtc atggagctgc caacaaagcc tggcaccttc gacctgggcc      120

tggccacatg gagcccttcc ttccaggggg aaacccaccg ggctcaggca cgccgcaggg      180

atgttggcag gcagctgcct gagtacaagg ctgtggtggt gggcgccagt ggcgtgggca      240

agagtgcgct gaccatccag ctgaaccacc agtgcttcgt ggaggaccac gaccccacca      300

tccaggattc ctactggaag gagttgaccc tggacagtgg ggactgcatt ctgaatgtgc      360

tggacacagc agggcaggcc atccataggg ccctgcgtga ccagtgcctg gctgtctgtg      420

atggtgtgct gggcgtcttc gctctcgatg acccctcgtc tctgatccag ctgcagcaga      480

tatgggccac ctggggccct caccccgccc agccccttgt cctcgtgggc aacaagtgtg      540

accttgtgac cactgctgga gatgctcatg ccgctgctgc agccctcgca cacagctggg      600

gggcccactt cgtggagacc tcggccaaaa cacggcaagg cgtggaggag gccttttccc      660

tgctggtcca tgagatccag agggtccagg aggccatggc gaaggagccc atggcaaggt      720

cctgtaggga gaagacccgg caccagaagg ccacctgcca ctgtggctgc tctgtggcct      780

gaaggtcttg gccaagaaat gtagaccttt ccccaggcca gggtga                     826


<210>  219
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  219

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  220
<211>  720
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  220
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  221
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  221

Met Arg Ser Ser Lys Asn Val Ile Lys Glu Phe Met Arg Phe Lys Val 
1               5                   10                  15      


Arg Met Glu Gly Thr Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
            20                  25                  30          


Gly Glu Gly Arg Pro Tyr Glu Gly His Asn Thr Val Lys Leu Lys Val 
        35                  40                  45              


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
    50                  55                  60                  


Phe Gln Tyr Gly Ser Lys Val Tyr Val Lys His Pro Ala Asp Ile Pro 
65                  70                  75                  80  


Asp Tyr Lys Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 
                85                  90                  95      


Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 
            100                 105                 110         


Leu Gln Asp Gly Cys Phe Ile Tyr Lys Val Lys Phe Ile Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 
    130                 135                 140                 


Ala Ser Thr Glu Arg Leu Tyr Pro Arg Asp Gly Val Leu Lys Gly Glu 
145                 150                 155                 160 


Ile His Lys Ala Leu Lys Leu Lys Asp Gly Gly His Tyr Leu Val Glu 
                165                 170                 175     


Phe Lys Ser Ile Tyr Met Ala Lys Lys Pro Val Gln Leu Pro Gly Tyr 
            180                 185                 190         


Tyr Tyr Val Asp Ser Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 
        195                 200                 205             


Thr Ile Val Glu Gln Tyr Glu Arg Thr Glu Gly Arg His His Leu Phe 
    210                 215                 220                 


Leu 
225 


<210>  222
<211>  678
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  222
atgaggtctt ccaagaatgt tatcaaggag ttcatgaggt ttaaggttcg catggaagga       60

acggtcaatg ggcacgagtt tgaaatagaa ggcgaaggag aggggaggcc atacgaaggc      120

cacaataccg taaagcttaa ggtaaccaag gggggacctt tgccatttgc ttgggatatt      180

ttgtcaccac aatttcagta tggaagcaag gtatatgtca agcaccctgc cgacatacca      240

gactataaaa agctgtcatt tcctgaagga tttaaatggg aaagggtcat gaactttgaa      300

gacggtggcg tcgttactgt aacccaggat tccagtttgc aggatggctg tttcatctac      360

aaggtcaagt tcattggcgt gaactttcct tccgatggac ctgttatgca aaagaagaca      420

atgggctggg aagccagcac tgagcgtttg tatcctcgtg atggcgtgtt gaaaggagag      480

attcataagg ctctgaagct gaaagacggt ggtcattacc tagttgaatt caaaagtatt      540

tacatggcaa agaagcctgt gcagctacca gggtactact atgttgactc caaactggat      600

ataacaagcc acaacgaaga ctatacaatc gttgagcagt atgaaagaac cgagggacgc      660

caccatctgt tcctttaa                                                    678


