                         SEQUENCE LISTING

<110>  Institut National de la Recherche Agronomique
 
<120>  Protine  activit dextrane-saccharase et applications

<130>  BCT150203 QT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dextrane saccharase

<400>  1

Met Lys Ile Lys Glu Thr Ile Thr Arg Lys Lys Leu Tyr Lys Ser Gly 
1               5                   10                  15      


Lys Ser Trp Val Ala Ala Ala Thr Ala Phe Ala Val Met Gly Val Ser 
            20                  25                  30          


Ala Val Thr Thr Val Ser Ala Asp Thr Gln Thr Pro Val Gly Thr Thr 
        35                  40                  45              


Gln Ser Gln Gln Asp Leu Thr Gly Gln Thr Gly Gln Asp Lys Pro Thr 
    50                  55                  60                  


Thr Lys Glu Val Ile Asp Lys Lys Glu Pro Val Pro Arg Val Ser Ala 
65                  70                  75                  80  


Gln Asn Ala Gly Asp Leu Ser Ala Asp Ala Lys Thr Thr Lys Ala Asp 
                85                  90                  95      


Asp Lys Gln Asp Thr Gln Pro Thr Asn Ala Gln Leu Pro Asp Gln Gly 
            100                 105                 110         


Asn Lys Gln Thr Asn Ser Asn Ser Asp Lys Gly Val Lys Glu Ser Thr 
        115                 120                 125             


Thr Ala Pro Val Lys Thr Thr Asp Val Pro Ser Lys Ser Val Ala Pro 
    130                 135                 140                 


Glu Thr Asn Thr Ser Ile Asn Ala Ser Asp Ala Ile Ser Lys Ser Gln 
145                 150                 155                 160 


Glu Lys Gln Phe Glu Lys Ala Pro Asp Ser Val Pro Glu Thr Ile Thr 
                165                 170                 175     


Gly Gly Arg Tyr Ser Leu Lys Asp Gly Tyr Tyr Val Tyr Leu Asp Lys 
            180                 185                 190         


Gln Gly Lys Gln Val Val Gly Pro Lys Asn Ile Asp Asn His Leu Gln 
        195                 200                 205             


Tyr Phe Asp Glu Thr Thr Gly Lys Gln Val Lys Gly Asp Phe Arg Ser 
    210                 215                 220                 


Val Asn Gly Lys Arg Ile Tyr Phe Asn Ala Asn Leu Gly Tyr Ala Asp 
225                 230                 235                 240 


Asp Tyr Thr Thr Asp Val Ala Gly Lys Leu Val Gly Tyr Asp Ser Asn 
                245                 250                 255     


Gly Asn Gln Val Lys Ala Gly Tyr Val Thr Asn Ser Gln Gly Lys Thr 
            260                 265                 270         


Tyr Tyr Phe Asn Asn Gln Gly Glu Ala Ile Ile Gly Leu Lys Thr Asp 
        275                 280                 285             


Asn Asn Lys Thr Gln Tyr Phe Gly Pro Asp Gly Ala Gln Val Lys Gly 
    290                 295                 300                 


Ala Phe Gln Gln Val Asn Gly Lys Asn Ile Tyr Phe Asp Ala Gln Thr 
305                 310                 315                 320 


Gly Tyr Ala Arg Gln Asn Val Gly Phe Leu Asp Gly Thr Ala Lys Gly 
                325                 330                 335     


Phe Asp Glu Gln Gly Asn Gln Ile Lys Ser Gly Ile Ala Thr Asp Leu 
            340                 345                 350         


Ser Gly Asn Val Tyr Tyr Phe Asp Ala Ser Gly Lys Met Leu Thr Gly 
        355                 360                 365             


Val Gln Asn Ile Asp Gly Lys Lys Tyr Tyr Phe Asp Glu Gln Gly His 
    370                 375                 380                 


Arg Arg Arg Asn Tyr Ala Gly Val Phe Asn Asn Glu Phe Ile Tyr Phe 
385                 390                 395                 400 


Gly Leu Asp Gly Val Gly Gln Ser Ala Ile Glu Tyr Gln Phe Glu Lys 
                405                 410                 415     


Gly Leu Thr Ser Gln Asn Ser Val Ala Thr Ser His Asn Ala Ala Lys 
            420                 425                 430         


Ser Tyr Asp Thr Lys Ser Phe Thr Asn Val Asp Gly Phe Leu Thr Ala 
        435                 440                 445             


Asn Ser Trp Tyr Arg Pro Thr Asp Ile Leu Arg Asn Gly Thr Lys Trp 
    450                 455                 460                 


Glu Pro Ser Thr Glu Thr Asp Phe Arg Pro Leu Leu Met Thr Trp Trp 
465                 470                 475                 480 


Pro Asp Lys Glu Val Gln Ala Asn Tyr Leu Asn Tyr Met Ser Ala Leu 
                485                 490                 495     


Gly Leu Gly Asp Gln Lys Ile Tyr Thr Gly Ala Ser Ser Gln Leu Asp 
            500                 505                 510         


Leu Asn Asn Ala Ala Leu Ile Val Gln Glu Ala Ile Glu Lys Lys Ile 
        515                 520                 525             


Ser Leu Glu Lys Ser Thr Lys Trp Leu Asp Asp Ser Ile Lys Ser Phe 
    530                 535                 540                 


Ile Lys Ser Lys Arg Lys Asp Ile Gln Gly Asn Leu Val Asp Thr Asn 
545                 550                 555                 560 


Pro Gly Trp Thr Ile Asp Ser Glu Thr Gly Ser Thr Asn His Leu Gln 
                565                 570                 575     


Asn Gly Ala Phe Ile Phe Thr Asn Ser Pro Leu Val Pro Glu Ala Asn 
            580                 585                 590         


Ala Ala Glu Gly Asn Arg Leu Ile Asn Arg Thr Pro Ser Gln Gln Thr 
        595                 600                 605             


Gly Asn His Ile Ser Tyr Ala Ser Gln Pro Tyr Ser Gly Asp Asp Trp 
    610                 615                 620                 


Gly Tyr Glu Leu Leu Leu Gly Asn Asp Val Asp Asn Ser Asn Pro Ile 
625                 630                 635                 640 


Val Gln Ala Glu Gln Leu Asn Trp Ile His Tyr Leu Met Asn Phe Gly 
                645                 650                 655     


Thr Ile Thr Ala Pro Gln Asp Pro Asp Ala His Leu Ala Asn Phe Asp 
            660                 665                 670         


Ser Ile Arg Ile Asp Ala Val Asp Asn Val Asp Ala Asp Leu Leu Gln 
        675                 680                 685             


Ile Ala Gly Asp Tyr Phe Lys Ala Ala Tyr Gln Val Gly Glu Asn Asp 
    690                 695                 700                 


Lys Asn Ala Asn Gln His Ile His Ile Leu Glu Asp Trp Ser Pro Asn 
705                 710                 715                 720 


Asp Val Trp Tyr Asn Gln Gln Val Asn Gly Asn Ser Gln Leu Thr Met 
                725                 730                 735     


Asp Ala Thr Met Gln Asn Gln Leu Leu Ala Ser Leu Thr Arg Pro Ile 
            740                 745                 750         


Thr Ser Arg Asp Ser Met Lys Ser Phe Thr Lys Asp Ala Leu Leu Val 
        755                 760                 765             


His Arg Thr Ala Asp Asn Ser Tyr Asn Gln Ala Val Pro Asn Tyr Ser 
    770                 775                 780                 


Phe Ile Arg Ala His Asp Ser Glu Val Gln Thr Ile Ile Ala Lys Ile 
785                 790                 795                 800 


Ile Ser Asp Lys His Pro Asp Leu Tyr Pro Thr Val Asp Lys Ala Leu 
                805                 810                 815     


Leu Ala Lys Asp Ser Ala Leu Tyr Asp Glu Ala Phe Thr Glu Tyr Asn 
            820                 825                 830         


Ala Asp Met Gln Lys Ile Ser Ser Gln Lys Gln Tyr Thr His Asn Asn 
        835                 840                 845             


Met Pro Ser Ala Tyr Ala Ile Leu Leu Thr Asn Lys Asp Thr Val Pro 
    850                 855                 860                 


Arg Val Tyr Tyr Gly Asp Leu Phe Thr Asp Asn Gly Glu Tyr Met Ala 
865                 870                 875                 880 


Asn Lys Thr Pro Tyr Tyr Asp Ala Ile Thr Ser Leu Leu Thr Ala Arg 
                885                 890                 895     


Thr Lys Phe Val Ser Gly Gly Gln Ser Leu Ser Val Asp Lys Asn Asp 
            900                 905                 910         


Val Leu Thr Ser Val Arg Tyr Gly Lys Gly Ala Leu Ser Ala Thr Asp 
        915                 920                 925             


Asn Gly Ser Ser Asp Thr Arg Asn Gln Gly Ile Gly Val Ile Val Ser 
    930                 935                 940                 


Asn Asn Pro Asn Leu Asp Leu Asn Asn Asp Lys Val Thr Leu Ser Met 
945                 950                 955                 960 


Gly Ile Ser His Ala His Gln Ala Tyr Arg Pro Leu Leu Leu Thr Asn 
                965                 970                 975     


Ser Gln Gly Ile Val Ala Tyr Ala Thr Asp Ser Glu Val Pro Gln Asn 
            980                 985                 990         


Leu Tyr Lys Thr Thr Asn Asp Lys  Gly Glu Leu Thr Phe  Asp Ala Ser 
        995                 1000                 1005             


Glu Ile  Lys Gly Tyr Asp Thr  Val Gln Thr Ser Gly  Tyr Leu Ala 
    1010                 1015                 1020             


Val Trp  Val Pro Val Gly Ala  Ser Asp Glu Gln Asp  Ala Arg Thr 
    1025                 1030                 1035             


Ile Ala  Ser Thr Glu Lys Asn  Asn Gly Asn Ser Val  Tyr His Ser 
    1040                 1045                 1050             


Asn Ala  Ala Leu Asp Ser Gln  Leu Ile Tyr Glu Gly  Phe Ser Asn 
    1055                 1060                 1065             


Phe Gln  Thr Val Pro Ser Lys  Asn Ala Ser Ala Asp  Glu Tyr Ala 
    1070                 1075                 1080             


Asn Val  Ile Ile Ala Lys His  Ala Ala Asp Phe Asn  Lys Trp Gly 
    1085                 1090                 1095             


Val Thr  Ser Phe Gln Met Ala  Pro Gln Tyr Arg Ser  Ser Thr Asp 
    1100                 1105                 1110             


Gly Ser  Phe Leu Asp Ala Val  Asp Thr Val Gln Asn  Gly Tyr Ala 
    1115                 1120                 1125             


Phe Thr  Asp Arg Tyr Asp Leu  Gly Phe Asn Ala Ala  Asp Gly Ser 
    1130                 1135                 1140             


Lys Asn  Pro Thr Lys Tyr Gly  Thr Asp Glu Asp Leu  Arg Asn Ala 
    1145                 1150                 1155             


Ile Lys  Ser Leu His Ala Gln  Lys Thr Tyr Asp Gly  Ser Ser Ile 
    1160                 1165                 1170             


Gln Val  Met Ala Asp Phe Val  Pro Asp Gln Leu Tyr  Asn Met Pro 
    1175                 1180                 1185             


Leu Glu  Gln Ala Val Ser Val  Ile Arg Thr Asp Lys  Tyr Gly Val 
    1190                 1195                 1200             


Asn Ser  Glu Asn Pro Asp Ile  Gln Asn Ile Ile Tyr  Ala Ala Asn 
    1205                 1210                 1215             


Ile Lys  Ser Ser Gly Thr Asp  Tyr Gln Ser Ile Tyr  Gly Gly Lys 
    1220                 1225                 1230             


Tyr Leu  Ala Glu Leu Gln Lys  Asn Pro Leu Phe Lys  Ser Leu Phe 
    1235                 1240                 1245             


Asp Arg  Ile Gln Ile Ser Thr  Lys Lys Thr Ile Asp  Pro Asn Thr 
    1250                 1255                 1260             


Arg Ile  Thr Gln Trp Ser Ala  Lys Tyr Phe Asn Gly  Ser Asn Ile 
    1265                 1270                 1275             


Gln Gly  Lys Gly Ile Asn Tyr  Val Leu Lys Asp Trp  Ala Ser Asn 
    1280                 1285                 1290             


Lys Tyr  Phe Asn Val Ser Ser  Asn Asp Asp Met Tyr  Ser Arg Leu 
    1295                 1300                 1305             


Pro Lys  Gln Leu Met Asn Gln  Glu Ser Asn Thr Gly  Phe Ile Val 
    1310                 1315                 1320             


Asp Asp  Ile Gly Val Lys Tyr  Tyr Ser Ile Ser Gly  Tyr Gln Ala 
    1325                 1330                 1335             


Lys Asn  Thr Phe Val Glu Asp  Gly Asn Gly Glu Trp  Tyr Tyr Phe 
    1340                 1345                 1350             


Asp Asn  Asp Gly Tyr Met Val  Lys Ser Thr Glu Glu  Ser Gly Pro 
    1355                 1360                 1365             


Leu Arg  Thr Val Asn Ala Ser  Ser Lys Lys Tyr Tyr  Ile Leu Pro 
    1370                 1375                 1380             


Asn Gly  Val Glu Ile Arg Asn  Ser Phe Gly Gln Asp  Ile Gln Gly 
    1385                 1390                 1395             


Asn Thr  Tyr Tyr Phe Asp Ala  Arg Gly Glu Met Val  Thr Ser Gln 
    1400                 1405                 1410             


Tyr Ile  Ser Asp Asp Thr Gln  Asn Ile Tyr Tyr Phe  Asn Asn Asp 
    1415                 1420                 1425             


Gly Thr  Met Ala Lys Gly Leu  Ile Gln Leu Asn Thr  Asn Leu Gln 
    1430                 1435                 1440             


Tyr Phe  Gly Thr Asn Gly Ala  Gln Leu Lys Gly Ala  Tyr Val His 
    1445                 1450                 1455             


Asp Ile  Ser Ser Asp Lys Trp  Tyr Gln Phe Asp Ala  Gly Ser Gly 
    1460                 1465                 1470             


Asn Gly  Arg Gln Leu Thr Gln  Arg Pro Asp Asp Val  Asn Ala Asn 
    1475                 1480                 1485             


Asn Tyr  Ile Ser Ile Asp Ser  Ser Ser Asn Ile Gly  Val Asn Thr 
    1490                 1495                 1500             


Asp Tyr  Thr Ala Tyr Ile Thr  Ser Ser Leu Arg Glu  Asp Gly Leu 
    1505                 1510                 1515             


Phe Ala  Asn Ala Pro Tyr Gly  Val Val Thr Lys Asp  Gln Asn Gly 
    1520                 1525                 1530             


Asn Asp  Leu Lys Trp Gln Tyr  Ile Asn His Thr Lys  Gln Tyr Glu 
    1535                 1540                 1545             


Gly Gln  Gln Val Gln Val Thr  Arg Gln Tyr Thr Asp  Ser Lys Gly 
    1550                 1555                 1560             


Val Ser  Trp Asn Leu Ile Thr  Phe Ala Gly Gly Asp  Leu Gln Gly 
    1565                 1570                 1575             


Gln Lys  Leu Trp Val Asp Ser  Arg Ala Leu Thr Met  Thr Pro Phe 
    1580                 1585                 1590             


Lys Thr  Met Asn Gln Ile Ser  Phe Ile Ser Tyr Ala  Asn Arg Asn 
    1595                 1600                 1605             


Asp Gly  Leu Phe Leu Asn Ala  Pro Tyr Gln Val Lys  Gly Tyr Gln 
    1610                 1615                 1620             


Leu Ala  Gly Met Ser Asn Gln  Tyr Lys Gly Gln Gln  Val Thr Ile 
    1625                 1630                 1635             


Ala Gly  Val Ala Asn Val Ser  Gly Lys Asp Trp Ser  Leu Ile Ser 
    1640                 1645                 1650             


Phe Asn  Gly Thr Gln Tyr Trp  Ile Asp Ser Gln Ala  Leu Asn Thr 
    1655                 1660                 1665             


Asn Phe  Thr His Asp Met Asn  Gln Lys Val Phe Val  Asn Thr Thr 
    1670                 1675                 1680             


Ser Asn  Leu Asp Gly Leu Phe  Leu Asn Ala Pro Tyr  Arg Gln Pro 
    1685                 1690                 1695             


Gly Tyr  Lys Leu Ala Gly Leu  Ala Lys Asn Tyr Asn  Asn Gln Thr 
    1700                 1705                 1710             


Val Thr  Val Ser Gln Gln Tyr  Phe Asp Asp Gln Gly  Thr Val Trp 
    1715                 1720                 1725             


Ser Gln  Val Val Leu Gly Gly  Gln Thr Val Trp Val  Asp Asn His 
    1730                 1735                 1740             


Ala Leu  Ala Gln Met Gln Val  Arg Asp Thr Asn Gln  Gln Leu Tyr 
    1745                 1750                 1755             


Val Asn  Ser Asn Gly Arg Asn  Asp Gly Leu Phe Leu  Asn Ala Pro 
    1760                 1765                 1770             


Tyr Arg  Gly Gln Gly Ser Gln  Leu Ile Gly Met Thr  Ala Asp Tyr 
    1775                 1780                 1785             


Asn Gly  Gln His Val Gln Val  Thr Lys Gln Gly Gln  Asp Ala Tyr 
    1790                 1795                 1800             


Gly Ala  Gln Trp Arg Leu Ile  Thr Leu Asn Asn Gln  Gln Val Trp 
    1805                 1810                 1815             


Val Asp  Ser Arg Ala Leu Ser  Thr Thr Ile Met Gln  Ala Met Asn 
    1820                 1825                 1830             


Asp Asp  Met Tyr Val Asn Ser  Ser Gln Arg Thr Asp  Gly Leu Trp 
    1835                 1840                 1845             


Leu Asn  Ala Pro Tyr Thr Met  Ser Gly Ala Lys Trp  Ala Gly Asp 
    1850                 1855                 1860             


Thr Arg  Ser Ala Asn Gly Arg  Tyr Val His Ile Ser  Lys Ala Tyr 
    1865                 1870                 1875             


Ser Asn  Glu Val Gly Asn Thr  Tyr Tyr Leu Thr Asn  Leu Asn Gly 
    1880                 1885                 1890             


Gln Ser  Thr Trp Ile Asp Lys  Arg Ala Phe Thr Ala  Thr Phe Asp 
    1895                 1900                 1905             


Gln Val  Val Ala Leu Asn Ala  Thr Ile Val Ala Arg  Gln Arg Pro 
    1910                 1915                 1920             


Asp Gly  Met Phe Lys Thr Ala  Pro Tyr Gly Glu Ala  Gly Ala Gln 
    1925                 1930                 1935             


Phe Val  Asp Tyr Val Thr Asn  Tyr Asn Gln Gln Thr  Val Pro Val 
    1940                 1945                 1950             


Thr Lys  Gln His Ser Asp Ala  Gln Gly Asn Gln Trp  Tyr Leu Ala 
    1955                 1960                 1965             


Thr Val  Asn Gly Thr Gln Tyr  Trp Ile Asp Gln Arg  Ser Phe Ser 
    1970                 1975                 1980             


Pro Val  Val Thr Lys Val Val  Asp Tyr Gln Ala Lys  Ile Val Pro 
    1985                 1990                 1995             


Arg Thr  Thr Arg Asp Gly Val  Phe Ser Gly Ala Pro  Tyr Gly Glu 
    2000                 2005                 2010             


Val Asn  Ala Lys Leu Val Asn  Met Ala Thr Ala Tyr  Gln Asn Gln 
    2015                 2020                 2025             


Val Val  His Ala Thr Gly Glu  Tyr Thr Asn Ala Ser  Gly Ile Thr 
    2030                 2035                 2040             


Trp Ser  Gln Phe Ala Leu Ser  Gly Gln Glu Asp Lys  Leu Trp Ile 
    2045                 2050                 2055             


Asp Lys  Arg Ala Leu Gln Ala  
    2060                 2065 


<210>  2
<211>  1392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated dextrane saccharase

<400>  2

Gln Thr Pro Val Gly Thr Thr Gln Ser Gln Gln Asp Leu Thr Gly Gln 
1               5                   10                  15      


Thr Gly Gln Asp Lys Pro Thr Thr Lys Glu Val Ile Asp Lys Lys Glu 
            20                  25                  30          


Pro Val Pro Arg Val Ser Ala Gln Asn Ala Gly Asp Leu Ser Ala Asp 
        35                  40                  45              


Ala Lys Thr Thr Lys Ala Asp Asp Lys Gln Asp Thr Gln Pro Thr Asn 
    50                  55                  60                  


Ala Gln Leu Pro Asp Gln Gly Asn Lys Gln Thr Asn Ser Asn Ser Asp 
65                  70                  75                  80  


Lys Gly Val Lys Glu Ser Thr Thr Ala Pro Val Lys Thr Thr Asp Val 
                85                  90                  95      


Pro Ser Lys Ser Val Ala Pro Glu Thr Asn Thr Ser Ile Asn Ala Ser 
            100                 105                 110         


Asp Ala Ile Ser Lys Ser Gln Glu Lys Gln Phe Glu Lys Ala Pro Asp 
        115                 120                 125             


Ser Val Pro Glu Thr Ile Thr Gly Gly Arg Tyr Ser Leu Lys Asp Gly 
    130                 135                 140                 


Tyr Tyr Val Tyr Leu Asp Lys Gln Gly Lys Gln Val Val Gly Pro Lys 
145                 150                 155                 160 


Asn Ile Asp Asn His Leu Gln Tyr Phe Asp Glu Thr Thr Gly Lys Gln 
                165                 170                 175     


Val Lys Gly Asp Phe Arg Ser Val Asn Gly Lys Arg Ile Tyr Phe Asn 
            180                 185                 190         


Ala Asn Leu Gly Tyr Ala Asp Asp Tyr Thr Thr Asp Val Ala Gly Lys 
        195                 200                 205             


Leu Val Gly Tyr Asp Ser Asn Gly Asn Gln Val Lys Ala Gly Tyr Val 
    210                 215                 220                 


Thr Asn Ser Gln Gly Lys Thr Tyr Tyr Phe Asn Asn Gln Gly Glu Ala 
225                 230                 235                 240 


Ile Ile Gly Leu Lys Thr Asp Asn Asn Lys Thr Gln Tyr Phe Gly Pro 
                245                 250                 255     


Asp Gly Ala Gln Val Lys Gly Ala Phe Gln Gln Val Asn Gly Lys Asn 
            260                 265                 270         


Ile Tyr Phe Asp Ala Gln Thr Gly Tyr Ala Arg Gln Asn Val Gly Phe 
        275                 280                 285             


Leu Asp Gly Thr Ala Lys Gly Phe Asp Glu Gln Gly Asn Gln Ile Lys 
    290                 295                 300                 


Ser Gly Ile Ala Thr Asp Leu Ser Gly Asn Val Tyr Tyr Phe Asp Ala 
305                 310                 315                 320 


Ser Gly Lys Met Leu Thr Gly Val Gln Asn Ile Asp Gly Lys Lys Tyr 
                325                 330                 335     


Tyr Phe Asp Glu Gln Gly His Arg Arg Arg Asn Tyr Ala Gly Val Phe 
            340                 345                 350         


Asn Asn Glu Phe Ile Tyr Phe Gly Leu Asp Gly Val Gly Gln Ser Ala 
        355                 360                 365             


Ile Glu Tyr Gln Phe Glu Lys Gly Leu Thr Ser Gln Asn Ser Val Ala 
    370                 375                 380                 


Thr Ser His Asn Ala Ala Lys Ser Tyr Asp Thr Lys Ser Phe Thr Asn 
385                 390                 395                 400 


Val Asp Gly Phe Leu Thr Ala Asn Ser Trp Tyr Arg Pro Thr Asp Ile 
                405                 410                 415     


Leu Arg Asn Gly Thr Lys Trp Glu Pro Ser Thr Glu Thr Asp Phe Arg 
            420                 425                 430         


Pro Leu Leu Met Thr Trp Trp Pro Asp Lys Glu Val Gln Ala Asn Tyr 
        435                 440                 445             


Leu Asn Tyr Met Ser Ala Leu Gly Leu Gly Asp Gln Lys Ile Tyr Thr 
    450                 455                 460                 


Gly Ala Ser Ser Gln Leu Asp Leu Asn Asn Ala Ala Leu Ile Val Gln 
465                 470                 475                 480 


Glu Ala Ile Glu Lys Lys Ile Ser Leu Glu Lys Ser Thr Lys Trp Leu 
                485                 490                 495     


Asp Asp Ser Ile Lys Ser Phe Ile Lys Ser Lys Arg Lys Asp Ile Gln 
            500                 505                 510         


Gly Asn Leu Val Asp Thr Asn Pro Gly Trp Thr Ile Asp Ser Glu Thr 
        515                 520                 525             


Gly Ser Thr Asn His Leu Gln Asn Gly Ala Phe Ile Phe Thr Asn Ser 
    530                 535                 540                 


Pro Leu Val Pro Glu Ala Asn Ala Ala Glu Gly Asn Arg Leu Ile Asn 
545                 550                 555                 560 


Arg Thr Pro Ser Gln Gln Thr Gly Asn His Ile Ser Tyr Ala Ser Gln 
                565                 570                 575     


Pro Tyr Ser Gly Asp Asp Trp Gly Tyr Glu Leu Leu Leu Gly Asn Asp 
            580                 585                 590         


Val Asp Asn Ser Asn Pro Ile Val Gln Ala Glu Gln Leu Asn Trp Ile 
        595                 600                 605             


His Tyr Leu Met Asn Phe Gly Thr Ile Thr Ala Pro Gln Asp Pro Asp 
    610                 615                 620                 


Ala His Leu Ala Asn Phe Asp Ser Ile Arg Ile Asp Ala Val Asp Asn 
625                 630                 635                 640 


Val Asp Ala Asp Leu Leu Gln Ile Ala Gly Asp Tyr Phe Lys Ala Ala 
                645                 650                 655     


Tyr Gln Val Gly Glu Asn Asp Lys Asn Ala Asn Gln His Ile His Ile 
            660                 665                 670         


Leu Glu Asp Trp Ser Pro Asn Asp Val Trp Tyr Asn Gln Gln Val Asn 
        675                 680                 685             


Gly Asn Ser Gln Leu Thr Met Asp Ala Thr Met Gln Asn Gln Leu Leu 
    690                 695                 700                 


Ala Ser Leu Thr Arg Pro Ile Thr Ser Arg Asp Ser Met Lys Ser Phe 
705                 710                 715                 720 


Thr Lys Asp Ala Leu Leu Val His Arg Thr Ala Asp Asn Ser Tyr Asn 
                725                 730                 735     


Gln Ala Val Pro Asn Tyr Ser Phe Ile Arg Ala His Asp Ser Glu Val 
            740                 745                 750         


Gln Thr Ile Ile Ala Lys Ile Ile Ser Asp Lys His Pro Asp Leu Tyr 
        755                 760                 765             


Pro Thr Val Asp Lys Ala Leu Leu Ala Lys Asp Ser Ala Leu Tyr Asp 
    770                 775                 780                 


Glu Ala Phe Thr Glu Tyr Asn Ala Asp Met Gln Lys Ile Ser Ser Gln 
785                 790                 795                 800 


Lys Gln Tyr Thr His Asn Asn Met Pro Ser Ala Tyr Ala Ile Leu Leu 
                805                 810                 815     


Thr Asn Lys Asp Thr Val Pro Arg Val Tyr Tyr Gly Asp Leu Phe Thr 
            820                 825                 830         


Asp Asn Gly Glu Tyr Met Ala Asn Lys Thr Pro Tyr Tyr Asp Ala Ile 
        835                 840                 845             


Thr Ser Leu Leu Thr Ala Arg Thr Lys Phe Val Ser Gly Gly Gln Ser 
    850                 855                 860                 


Leu Ser Val Asp Lys Asn Asp Val Leu Thr Ser Val Arg Tyr Gly Lys 
865                 870                 875                 880 


Gly Ala Leu Ser Ala Thr Asp Asn Gly Ser Ser Asp Thr Arg Asn Gln 
                885                 890                 895     


Gly Ile Gly Val Ile Val Ser Asn Asn Pro Asn Leu Asp Leu Asn Asn 
            900                 905                 910         


Asp Lys Val Thr Leu Ser Met Gly Ile Ser His Ala His Gln Ala Tyr 
        915                 920                 925             


Arg Pro Leu Leu Leu Thr Asn Ser Gln Gly Ile Val Ala Tyr Ala Thr 
    930                 935                 940                 


Asp Ser Glu Val Pro Gln Asn Leu Tyr Lys Thr Thr Asn Asp Lys Gly 
945                 950                 955                 960 


Glu Leu Thr Phe Asp Ala Ser Glu Ile Lys Gly Tyr Asp Thr Val Gln 
                965                 970                 975     


Thr Ser Gly Tyr Leu Ala Val Trp Val Pro Val Gly Ala Ser Asp Glu 
            980                 985                 990         


Gln Asp Ala Arg Thr Ile Ala Ser  Thr Glu Lys Asn Asn  Gly Asn Ser 
        995                 1000                 1005             


Val Tyr  His Ser Asn Ala Ala  Leu Asp Ser Gln Leu  Ile Tyr Glu 
    1010                 1015                 1020             


Gly Phe  Ser Asn Phe Gln Thr  Val Pro Ser Lys Asn  Ala Ser Ala 
    1025                 1030                 1035             


Asp Glu  Tyr Ala Asn Val Ile  Ile Ala Lys His Ala  Ala Asp Phe 
    1040                 1045                 1050             


Asn Lys  Trp Gly Val Thr Ser  Phe Gln Met Ala Pro  Gln Tyr Arg 
    1055                 1060                 1065             


Ser Ser  Thr Asp Gly Ser Phe  Leu Asp Ala Val Asp  Thr Val Gln 
    1070                 1075                 1080             


Asn Gly  Tyr Ala Phe Thr Asp  Arg Tyr Asp Leu Gly  Phe Asn Ala 
    1085                 1090                 1095             


Ala Asp  Gly Ser Lys Asn Pro  Thr Lys Tyr Gly Thr  Asp Glu Asp 
    1100                 1105                 1110             


Leu Arg  Asn Ala Ile Lys Ser  Leu His Ala Gln Lys  Thr Tyr Asp 
    1115                 1120                 1125             


Gly Ser  Ser Ile Gln Val Met  Ala Asp Phe Val Pro  Asp Gln Leu 
    1130                 1135                 1140             


Tyr Asn  Met Pro Leu Glu Gln  Ala Val Ser Val Ile  Arg Thr Asp 
    1145                 1150                 1155             


Lys Tyr  Gly Val Asn Ser Glu  Asn Pro Asp Ile Gln  Asn Ile Ile 
    1160                 1165                 1170             


Tyr Ala  Ala Asn Ile Lys Ser  Ser Gly Thr Asp Tyr  Gln Ser Ile 
    1175                 1180                 1185             


Tyr Gly  Gly Lys Tyr Leu Ala  Glu Leu Gln Lys Asn  Pro Leu Phe 
    1190                 1195                 1200             


Lys Ser  Leu Phe Asp Arg Ile  Gln Ile Ser Thr Lys  Lys Thr Ile 
    1205                 1210                 1215             


Asp Pro  Asn Thr Arg Ile Thr  Gln Trp Ser Ala Lys  Tyr Phe Asn 
    1220                 1225                 1230             


Gly Ser  Asn Ile Gln Gly Lys  Gly Ile Asn Tyr Val  Leu Lys Asp 
    1235                 1240                 1245             


Trp Ala  Ser Asn Lys Tyr Phe  Asn Val Ser Ser Asn  Asp Asp Met 
    1250                 1255                 1260             


Tyr Ser  Arg Leu Pro Lys Gln  Leu Met Asn Gln Glu  Ser Asn Thr 
    1265                 1270                 1275             


Gly Phe  Ile Val Asp Asp Ile  Gly Val Lys Tyr Tyr  Ser Ile Ser 
    1280                 1285                 1290             


Gly Tyr  Gln Ala Lys Asn Thr  Phe Val Glu Asp Gly  Asn Gly Glu 
    1295                 1300                 1305             


Trp Tyr  Tyr Phe Asp Asn Asp  Gly Tyr Met Val Lys  Ser Thr Glu 
    1310                 1315                 1320             


Glu Ser  Gly Pro Leu Arg Thr  Val Asn Ala Ser Ser  Lys Lys Tyr 
    1325                 1330                 1335             


Tyr Ile  Leu Pro Asn Gly Val  Glu Ile Arg Asn Ser  Phe Gly Gln 
    1340                 1345                 1350             


Asp Ile  Gln Gly Asn Thr Tyr  Tyr Phe Asp Ala Arg  Gly Glu Met 
    1355                 1360                 1365             


Val Thr  Ser Gln Tyr Ile Ser  Asp Asp Thr Gln Asn  Ile Tyr Tyr 
    1370                 1375                 1380             


Phe Asn  Asn Asp Gly Thr Met  Ala Lys 
    1385                 1390         


<210>  3
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
caccatgaaa ataaaagaaa caattacccg aaa                                    33


<210>  4
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  4
aagcttgcaa agcacgctta tcaatc                                            26


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
cacccaaacg ccggttggta caacacag                                          28


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
ttttgccatc gtaccatcgt tatt                                              24


