                         SEQUENCE LISTING

<110>  RGDI3, Inc.
 
<120>  Collagen IV replacement

<130>  2072.1004PCT

<140>  PCT/US xx/xxxxxx
<141>  2015-07-23

<150>  62/128,729
<151>  2015-03-05

<150>  62/072,490
<151>  2014-10-30

<150>  62/029,135
<151>  2014-07-25

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1669
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Gly Pro Gln Gly Thr Pro Gly Leu Ile Gly Gln Pro Gly Ala Lys Gly 
        515                 520                 525             


Glu Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Asp Lys Gly 
    530                 535                 540                 


Asp Pro Gly Phe Pro Gly Gln Pro Gly Met Pro Gly Arg Ala Gly Ser 
545                 550                 555                 560 


Pro Gly Arg Asp Gly His Pro Gly Leu Pro Gly Pro Lys Gly Ser Pro 
                565                 570                 575     


Gly Ser Val Gly Leu Lys Gly Glu Arg Gly Pro Pro Gly Gly Val Gly 
            580                 585                 590         


Phe Pro Gly Ser Arg Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Tyr 
        595                 600                 605             


Gly Pro Ala Gly Pro Ile Gly Asp Lys Gly Gln Ala Gly Phe Pro Gly 
    610                 615                 620                 


Gly Pro Gly Ser Pro Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Lys 
625                 630                 635                 640 


Ile Val Pro Leu Pro Gly Pro Pro Gly Ala Glu Gly Leu Pro Gly Ser 
                645                 650                 655     


Pro Gly Phe Pro Gly Pro Gln Gly Asp Arg Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Arg Pro Gly Leu Pro Gly Glu Lys Gly Ala Val Gly Gln Pro Gly 
        675                 680                 685             


Ile Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Val Asp Gly Leu Pro 
    690                 695                 700                 


Gly Asp Met Gly Pro Pro Gly Thr Pro Gly Arg Pro Gly Phe Asn Gly 
705                 710                 715                 720 


Leu Pro Gly Asn Pro Gly Val Gln Gly Gln Lys Gly Glu Pro Gly Val 
                725                 730                 735     


Gly Leu Pro Gly Leu Lys Gly Leu Pro Gly Leu Pro Gly Ile Pro Gly 
            740                 745                 750         


Thr Pro Gly Glu Lys Gly Ser Ile Gly Val Pro Gly Val Pro Gly Glu 
        755                 760                 765             


His Gly Ala Ile Gly Pro Pro Gly Leu Gln Gly Ile Arg Gly Glu Pro 
    770                 775                 780                 


Gly Pro Pro Gly Leu Pro Gly Ser Val Gly Ser Pro Gly Val Pro Gly 
785                 790                 795                 800 


Ile Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Gly Gln Gly Pro Pro 
                805                 810                 815     


Gly Leu Ser Gly Pro Pro Gly Ile Lys Gly Glu Lys Gly Phe Pro Gly 
            820                 825                 830         


Phe Pro Gly Leu Asp Met Pro Gly Pro Lys Gly Asp Lys Gly Ala Gln 
        835                 840                 845             


Gly Leu Pro Gly Ile Thr Gly Gln Ser Gly Leu Pro Gly Leu Pro Gly 
    850                 855                 860                 


Gln Gln Gly Ala Pro Gly Ile Pro Gly Phe Pro Gly Ser Lys Gly Glu 
865                 870                 875                 880 


Met Gly Val Met Gly Thr Pro Gly Gln Pro Gly Ser Pro Gly Pro Val 
                885                 890                 895     


Gly Ala Pro Gly Leu Pro Gly Glu Lys Gly Asp His Gly Phe Pro Gly 
            900                 905                 910         


Ser Ser Gly Pro Arg Gly Asp Pro Gly Leu Lys Gly Asp Lys Gly Asp 
        915                 920                 925             


Val Gly Leu Pro Gly Lys Pro Gly Ser Met Asp Lys Val Asp Met Gly 
    930                 935                 940                 


Ser Met Lys Gly Gln Lys Gly Asp Gln Gly Glu Lys Gly Gln Ile Gly 
945                 950                 955                 960 


Pro Ile Gly Glu Lys Gly Ser Arg Gly Asp Pro Gly Thr Pro Gly Val 
                965                 970                 975     


Pro Gly Lys Asp Gly Gln Ala Gly Gln Pro Gly Gln Pro Gly Pro Lys 
            980                 985                 990         


Gly Asp Pro Gly Ile Ser Gly Thr  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Pro Lys  Gly Ser Val Gly Gly  Met Gly Leu Pro Gly  Thr Pro Gly 
    1010                 1015                 1020             


Glu Lys  Gly Val Pro Gly Ile  Pro Gly Pro Gln Gly  Ser Pro Gly 
    1025                 1030                 1035             


Leu Pro  Gly Asp Lys Gly Ala  Lys Gly Glu Lys Gly  Gln Ala Gly 
    1040                 1045                 1050             


Pro Pro  Gly Ile Gly Ile Pro  Gly Leu Arg Gly Glu  Lys Gly Asp 
    1055                 1060                 1065             


Gln Gly  Ile Ala Gly Phe Pro  Gly Ser Pro Gly Glu  Lys Gly Glu 
    1070                 1075                 1080             


Lys Gly  Ser Ile Gly Ile Pro  Gly Met Pro Gly Ser  Pro Gly Leu 
    1085                 1090                 1095             


Lys Gly  Ser Pro Gly Ser Val  Gly Tyr Pro Gly Ser  Pro Gly Leu 
    1100                 1105                 1110             


Pro Gly  Glu Lys Gly Asp Lys  Gly Leu Pro Gly Leu  Asp Gly Ile 
    1115                 1120                 1125             


Pro Gly  Val Lys Gly Glu Ala  Gly Leu Pro Gly Thr  Pro Gly Pro 
    1130                 1135                 1140             


Thr Gly  Pro Ala Gly Gln Lys  Gly Glu Pro Gly Ser  Asp Gly Ile 
    1145                 1150                 1155             


Pro Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Leu  Pro Gly Arg 
    1160                 1165                 1170             


Gly Phe  Pro Gly Phe Pro Gly  Ala Lys Gly Asp Lys  Gly Ser Lys 
    1175                 1180                 1185             


Gly Glu  Val Gly Phe Pro Gly  Leu Ala Gly Ser Pro  Gly Ile Pro 
    1190                 1195                 1200             


Gly Ser  Lys Gly Glu Gln Gly  Phe Met Gly Pro Pro  Gly Pro Gln 
    1205                 1210                 1215             


Gly Gln  Pro Gly Leu Pro Gly  Ser Pro Gly His Ala  Thr Glu Gly 
    1220                 1225                 1230             


Pro Lys  Gly Asp Arg Gly Pro  Gln Gly Gln Pro Gly  Leu Pro Gly 
    1235                 1240                 1245             


Leu Pro  Gly Pro Met Gly Pro  Pro Gly Leu Pro Gly  Ile Asp Gly 
    1250                 1255                 1260             


Val Lys  Gly Asp Lys Gly Asn  Pro Gly Trp Pro Gly  Ala Pro Gly 
    1265                 1270                 1275             


Val Pro  Gly Pro Lys Gly Asp  Pro Gly Phe Gln Gly  Met Pro Gly 
    1280                 1285                 1290             


Ile Gly  Gly Ser Pro Gly Ile  Thr Gly Ser Lys Gly  Asp Met Gly 
    1295                 1300                 1305             


Pro Pro  Gly Val Pro Gly Phe  Gln Gly Pro Lys Gly  Leu Pro Gly 
    1310                 1315                 1320             


Leu Gln  Gly Ile Lys Gly Asp  Gln Gly Asp Gln Gly  Val Pro Gly 
    1325                 1330                 1335             


Ala Lys  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Tyr Asp 
    1340                 1345                 1350             


Ile Ile  Lys Gly Glu Pro Gly  Leu Pro Gly Pro Glu  Gly Pro Pro 
    1355                 1360                 1365             


Gly Leu  Lys Gly Leu Gln Gly  Leu Pro Gly Pro Lys  Gly Gln Gln 
    1370                 1375                 1380             


Gly Val  Thr Gly Leu Val Gly  Ile Pro Gly Pro Pro  Gly Ile Pro 
    1385                 1390                 1395             


Gly Phe  Asp Gly Ala Pro Gly  Gln Lys Gly Glu Met  Gly Pro Ala 
    1400                 1405                 1410             


Gly Pro  Thr Gly Pro Arg Gly  Phe Pro Gly Pro Pro  Gly Pro Asp 
    1415                 1420                 1425             


Gly Leu  Pro Gly Ser Met Gly  Pro Pro Gly Thr Pro  Ser Val Asp 
    1430                 1435                 1440             


His Gly  Phe Leu Val Thr Arg  His Ser Gln Thr Ile  Asp Asp Pro 
    1445                 1450                 1455             


Gln Cys  Pro Ser Gly Thr Lys  Ile Leu Tyr His Gly  Tyr Ser Leu 
    1460                 1465                 1470             


Leu Tyr  Val Gln Gly Asn Glu  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Ala  Gly Ser Cys Leu Arg  Lys Phe Ser Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Ile Asn Asn Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Glu Pro Met Pro  Met Ser Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Glu Asn  Ile Arg Pro Phe Ile  Ser Arg Cys 
    1535                 1540                 1545             


Ala Val  Cys Glu Ala Pro Ala  Met Val Met Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Ile  Gln Ile Pro Pro Cys  Pro Ser Gly Trp Ser  Ser Leu Trp 
    1565                 1570                 1575             


Ile Gly  Tyr Ser Phe Val Met  His Thr Ser Ala Gly  Ala Glu Gly 
    1580                 1585                 1590             


Ser Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ser  Ala Pro Phe Ile Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ala Asn Ala Tyr Ser  Phe Trp Leu Ala Thr  Ile Glu Arg 
    1625                 1630                 1635             


Ser Glu  Met Phe Lys Lys Pro  Thr Pro Ser Thr Leu  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Arg Thr His Val Ser  Arg Cys Gln Val Cys  Met Arg Arg 
    1655                 1660                 1665             


Thr 
    


<210>  2
<211>  1712
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Thr  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Thr Gly Asp Phe  Gly Asp Ile Gly Asp  Thr Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Thr Thr Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Thr Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Thr Gly Val Thr Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Thr Gly Phe Pro Gly  Leu Thr Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Thr Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Thr Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Thr Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Thr Gly Asn  Pro Gly Ala Pro Gly  Thr Pro Gly 
    1310                 1315                 1320             


Thr Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Thr Gly Pro  Thr Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Thr Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Thr Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Thr Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Thr Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Thr Thr  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Thr Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Thr Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Thr Thr Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Thr Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Thr  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210>  3
<211>  1670
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Gly Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Leu Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Thr Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Thr Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Thr Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210>  4
<211>  1690
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Ser Leu His Ile Val Leu Met Arg Cys Ser Phe Arg Leu Thr 
1               5                   10                  15      


Lys Ser Leu Ala Thr Gly Pro Trp Ser Leu Ile Leu Ile Leu Phe Ser 
            20                  25                  30          


Val Gln Tyr Val Tyr Gly Ser Gly Lys Lys Tyr Ile Gly Pro Cys Gly 
        35                  40                  45              


Gly Arg Asp Cys Ser Val Cys His Cys Val Pro Glu Lys Gly Ser Arg 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Ile Gly Pro Leu Gly 
65                  70                  75                  80  


Ala Pro Gly Pro Ile Gly Leu Ser Gly Glu Lys Gly Met Arg Gly Asp 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Asp Lys Gly Asp Lys Gly Pro Thr 
            100                 105                 110         


Gly Val Pro Gly Phe Pro Gly Leu Asp Gly Ile Pro Gly His Pro Gly 
        115                 120                 125             


Pro Pro Gly Pro Arg Gly Lys Pro Gly Met Ser Gly His Asn Gly Ser 
    130                 135                 140                 


Arg Gly Asp Pro Gly Phe Pro Gly Gly Arg Gly Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Gly Pro Leu Gly His Pro Gly Glu Lys Gly Glu Lys Gly Asn Ser Val 
                165                 170                 175     


Phe Ile Leu Gly Ala Val Lys Gly Ile Gln Gly Asp Arg Gly Asp Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Ser Trp Gly Ala Gly Gly Pro Ala Gly 
        195                 200                 205             


Pro Thr Gly Tyr Pro Gly Glu Pro Gly Leu Val Gly Pro Pro Gly Gln 
    210                 215                 220                 


Pro Gly Arg Pro Gly Leu Lys Gly Asn Pro Gly Val Gly Val Lys Gly 
225                 230                 235                 240 


Gln Met Gly Asp Pro Gly Glu Val Gly Gln Gln Gly Ser Pro Gly Pro 
                245                 250                 255     


Thr Leu Leu Val Glu Pro Pro Asp Phe Cys Leu Tyr Lys Gly Glu Lys 
            260                 265                 270         


Gly Ile Lys Gly Ile Pro Gly Met Val Gly Leu Pro Gly Pro Pro Gly 
        275                 280                 285             


Arg Lys Gly Glu Ser Gly Ile Gly Ala Lys Gly Glu Lys Gly Ile Pro 
    290                 295                 300                 


Gly Phe Pro Gly Pro Arg Gly Asp Pro Gly Ser Tyr Gly Ser Pro Gly 
305                 310                 315                 320 


Phe Pro Gly Leu Lys Gly Glu Leu Gly Leu Val Gly Asp Pro Gly Leu 
                325                 330                 335     


Phe Gly Leu Ile Gly Pro Lys Gly Asp Pro Gly Asn Arg Gly His Pro 
            340                 345                 350         


Gly Pro Pro Gly Val Leu Val Thr Pro Pro Leu Pro Leu Lys Gly Pro 
        355                 360                 365             


Pro Gly Asp Pro Gly Phe Pro Gly Arg Tyr Gly Glu Thr Gly Asp Val 
    370                 375                 380                 


Gly Pro Pro Gly Pro Pro Gly Leu Leu Gly Arg Pro Gly Glu Ala Cys 
385                 390                 395                 400 


Ala Gly Met Ile Gly Pro Pro Gly Pro Gln Gly Phe Pro Gly Leu Pro 
                405                 410                 415     


Gly Leu Pro Gly Glu Ala Gly Ile Pro Gly Arg Pro Asp Ser Ala Pro 
            420                 425                 430         


Gly Lys Pro Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly Ala Pro Gly 
        435                 440                 445             


Leu Gln Gly Leu Pro Gly Ser Ser Val Ile Tyr Cys Ser Val Gly Asn 
    450                 455                 460                 


Pro Gly Pro Gln Gly Ile Lys Gly Lys Val Gly Pro Pro Gly Gly Arg 
465                 470                 475                 480 


Gly Pro Lys Gly Glu Lys Gly Asn Glu Gly Leu Cys Ala Cys Glu Pro 
                485                 490                 495     


Gly Pro Met Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Arg Gln Gly 
            500                 505                 510         


Ser Lys Gly Asp Leu Gly Leu Pro Gly Trp Leu Gly Thr Lys Gly Asp 
        515                 520                 525             


Pro Gly Pro Pro Gly Ala Glu Gly Pro Pro Gly Leu Pro Gly Lys His 
    530                 535                 540                 


Gly Ala Ser Gly Pro Pro Gly Asn Lys Gly Ala Lys Gly Asp Met Val 
545                 550                 555                 560 


Val Ser Arg Val Lys Gly His Lys Gly Glu Arg Gly Pro Asp Gly Pro 
                565                 570                 575     


Pro Gly Phe Pro Gly Gln Pro Gly Ser His Gly Arg Asp Gly His Ala 
            580                 585                 590         


Gly Glu Lys Gly Asp Pro Gly Pro Pro Gly Asp His Glu Asp Ala Thr 
        595                 600                 605             


Pro Gly Gly Lys Gly Phe Pro Gly Pro Leu Gly Pro Pro Gly Lys Ala 
    610                 615                 620                 


Gly Pro Val Gly Pro Pro Gly Leu Gly Phe Pro Gly Pro Pro Gly Glu 
625                 630                 635                 640 


Arg Gly His Pro Gly Val Pro Gly His Pro Gly Val Arg Gly Pro Asp 
                645                 650                 655     


Gly Leu Lys Gly Gln Lys Gly Asp Thr Ile Ser Cys Asn Val Thr Tyr 
            660                 665                 670         


Pro Gly Arg His Gly Pro Pro Gly Phe Asp Gly Pro Pro Gly Pro Lys 
        675                 680                 685             


Gly Phe Pro Gly Pro Gln Gly Ala Pro Gly Leu Ser Gly Ser Asp Gly 
    690                 695                 700                 


His Lys Gly Arg Pro Gly Thr Pro Gly Thr Ala Glu Ile Pro Gly Pro 
705                 710                 715                 720 


Pro Gly Phe Arg Gly Asp Met Gly Asp Pro Gly Phe Gly Gly Glu Lys 
                725                 730                 735     


Gly Ser Ser Pro Val Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Val 
            740                 745                 750         


Asn Gly Gln Lys Gly Ile Pro Gly Asp Pro Ala Phe Gly His Leu Gly 
        755                 760                 765             


Pro Pro Gly Lys Arg Gly Leu Ser Gly Val Pro Gly Ile Lys Gly Pro 
    770                 775                 780                 


Arg Gly Asp Pro Gly Cys Pro Gly Ala Glu Gly Pro Ala Gly Ile Pro 
785                 790                 795                 800 


Gly Phe Leu Gly Leu Lys Gly Pro Lys Gly Arg Glu Gly His Ala Gly 
                805                 810                 815     


Phe Pro Gly Val Pro Gly Pro Pro Gly His Ser Cys Glu Arg Gly Ala 
            820                 825                 830         


Pro Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Tyr Pro Gly Ser Pro 
        835                 840                 845             


Gly Ala Pro Gly Gly Lys Gly Gln Pro Gly Asp Val Gly Pro Pro Gly 
    850                 855                 860                 


Pro Ala Gly Met Lys Gly Leu Pro Gly Leu Pro Gly Arg Pro Gly Ala 
865                 870                 875                 880 


His Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Pro Phe Gly Asp Asp 
                885                 890                 895     


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Pro Arg Gly Leu Pro Gly 
            900                 905                 910         


Phe Pro Gly Phe Pro Gly Glu Arg Gly Lys Pro Gly Ala Glu Gly Cys 
        915                 920                 925             


Pro Gly Ala Lys Gly Glu Pro Gly Glu Lys Gly Met Ser Gly Leu Pro 
    930                 935                 940                 


Gly Asp Arg Gly Leu Arg Gly Ala Lys Gly Ala Ile Gly Pro Pro Gly 
945                 950                 955                 960 


Asp Glu Gly Glu Met Ala Ile Ile Ser Gln Lys Gly Thr Pro Gly Glu 
                965                 970                 975     


Pro Gly Pro Pro Gly Asp Asp Gly Phe Pro Gly Glu Arg Gly Asp Lys 
            980                 985                 990         


Gly Thr Pro Gly Met Gln Gly Arg  Arg Gly Glu Leu Gly  Arg Tyr Gly 
        995                 1000                 1005             


Pro Pro  Gly Phe His Arg Gly  Glu Pro Gly Glu Lys  Gly Gln Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Ser Thr  Gly Leu Arg 
    1025                 1030                 1035             


Gly Phe  Ile Gly Phe Pro Gly  Leu Pro Gly Asp Gln  Gly Glu Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Pro Pro Gly  Phe Ser Gly Ile Asp  Gly Ala Arg 
    1055                 1060                 1065             


Gly Pro  Lys Gly Asn Lys Gly  Asp Pro Ala Ser His  Phe Gly Pro 
    1070                 1075                 1080             


Pro Gly  Pro Lys Gly Glu Pro  Gly Ser Pro Gly Cys  Pro Gly His 
    1085                 1090                 1095             


Phe Gly  Ala Ser Gly Glu Gln  Gly Leu Pro Gly Ile  Gln Gly Pro 
    1100                 1105                 1110             


Arg Gly  Ser Pro Gly Arg Pro  Gly Pro Pro Gly Ser  Ser Gly Pro 
    1115                 1120                 1125             


Pro Gly  Cys Pro Gly Asp His  Gly Met Pro Gly Leu  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Glu Met Gly Asp Pro  Gly Pro Arg Gly Leu  Gln Gly Asp 
    1145                 1150                 1155             


Pro Gly  Ile Pro Gly Pro Pro  Gly Ile Lys Gly Pro  Ser Gly Ser 
    1160                 1165                 1170             


Pro Gly  Leu Asn Gly Leu His  Gly Leu Lys Gly Gln  Lys Gly Thr 
    1175                 1180                 1185             


Lys Gly  Ala Ser Gly Leu His  Asp Val Gly Pro Pro  Gly Pro Val 
    1190                 1195                 1200             


Gly Ile  Pro Gly Leu Lys Gly  Glu Arg Gly Asp Pro  Gly Ser Pro 
    1205                 1210                 1215             


Gly Ile  Ser Pro Pro Gly Pro  Arg Gly Lys Lys Gly  Pro Pro Gly 
    1220                 1225                 1230             


Pro Pro  Gly Ser Ser Gly Pro  Pro Gly Pro Ala Gly  Ala Thr Gly 
    1235                 1240                 1245             


Arg Ala  Pro Lys Asp Ile Pro  Asp Pro Gly Pro Pro  Gly Asp Gln 
    1250                 1255                 1260             


Gly Pro  Pro Gly Pro Asp Gly  Pro Arg Gly Ala Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Leu  Pro Gly Ser Val Asp  Leu Leu Arg Gly Glu  Pro Gly Asp 
    1280                 1285                 1290             


Cys Gly  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Tyr Lys Gly Phe Pro  Gly Cys Asp Gly Lys  Asp Gly Gln 
    1310                 1315                 1320             


Lys Gly  Pro Met Gly Phe Pro  Gly Pro Gln Gly Pro  His Gly Phe 
    1325                 1330                 1335             


Pro Gly  Pro Pro Gly Glu Lys  Gly Leu Pro Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Lys Gly  Pro Thr Gly Leu Pro  Gly Pro Arg Gly Glu  Pro Gly Pro 
    1355                 1360                 1365             


Pro Ala  Asp Val Asp Asp Cys  Pro Arg Ile Pro Gly  Leu Pro Gly 
    1370                 1375                 1380             


Ala Pro  Gly Met Arg Gly Pro  Glu Gly Ala Met Gly  Leu Pro Gly 
    1385                 1390                 1395             


Met Arg  Gly Pro Pro Gly Pro  Gly Cys Lys Gly Glu  Pro Gly Leu 
    1400                 1405                 1410             


Asp Gly  Arg Arg Gly Val Asp  Gly Val Pro Gly Ser  Pro Gly Pro 
    1415                 1420                 1425             


Pro Gly  Arg Lys Gly Asp Thr  Gly Glu Asp Gly Tyr  Pro Gly Gly 
    1430                 1435                 1440             


Pro Gly  Pro Pro Gly Pro Ile  Gly Asp Pro Gly Pro  Lys Gly Phe 
    1445                 1450                 1455             


Gly Pro  Gly Tyr Leu Gly Gly  Phe Leu Leu Val Leu  His Ser Gln 
    1460                 1465                 1470             


Thr Asp  Gln Glu Pro Thr Cys  Pro Leu Gly Met Pro  Arg Leu Trp 
    1475                 1480                 1485             


Thr Gly  Tyr Ser Leu Leu Tyr  Leu Glu Gly Gln Glu  Lys Ala His 
    1490                 1495                 1500             


Asn Gln  Asp Leu Gly Leu Ala  Gly Ser Cys Leu Pro  Val Phe Ser 
    1505                 1510                 1515             


Thr Leu  Pro Phe Ala Tyr Cys  Asn Ile His Gln Val  Cys His Tyr 
    1520                 1525                 1530             


Ala Gln  Arg Asn Asp Arg Ser  Tyr Trp Leu Ala Ser  Ala Ala Pro 
    1535                 1540                 1545             


Leu Pro  Met Met Pro Leu Ser  Glu Glu Ala Ile Arg  Pro Tyr Val 
    1550                 1555                 1560             


Ser Arg  Cys Ala Val Cys Glu  Ala Pro Ala Gln Ala  Val Ala Val 
    1565                 1570                 1575             


His Ser  Gln Asp Gln Ser Ile  Pro Pro Cys Pro Gln  Thr Trp Arg 
    1580                 1585                 1590             


Ser Leu  Trp Ile Gly Tyr Ser  Phe Leu Met His Thr  Gly Ala Gly 
    1595                 1600                 1605             


Asp Gln  Gly Gly Gly Gln Ala  Leu Met Ser Pro Gly  Ser Cys Leu 
    1610                 1615                 1620             


Glu Asp  Phe Arg Ala Ala Pro  Phe Leu Glu Cys Gln  Gly Arg Gln 
    1625                 1630                 1635             


Gly Thr  Cys His Phe Phe Ala  Asn Lys Tyr Ser Phe  Trp Leu Thr 
    1640                 1645                 1650             


Thr Val  Lys Ala Asp Leu Gln  Phe Ser Ser Ala Pro  Ala Pro Asp 
    1655                 1660                 1665             


Thr Leu  Lys Glu Ser Gln Ala  Gln Arg Gln Lys Ile  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Val Lys Tyr Ser  
    1685                 1690 


<210>  5
<211>  1685
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly 
            340                 345                 350         


Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Thr Ile Thr Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Thr Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Thr Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Thr Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Thr Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Thr Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Thr Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Thr Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Pro Pro Gly Leu Pro  Gly Asn Gly 
    1265                 1270                 1275             


Gly Ile  Lys Gly Glu Lys Gly  Asn Pro Gly Gln Pro  Gly Leu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Leu Lys Gly  Asp Gln Gly Pro Pro  Gly Leu Gln 
    1295                 1300                 1305             


Gly Asn  Pro Gly Arg Pro Gly  Leu Asn Gly Met Lys  Gly Asp Pro 
    1310                 1315                 1320             


Gly Leu  Pro Gly Val Pro Gly  Phe Pro Gly Met Lys  Gly Pro Ser 
    1325                 1330                 1335             


Gly Val  Pro Gly Ser Ala Gly  Pro Glu Gly Glu Pro  Gly Leu Ile 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly Pro Ser  Gly Gln Ser 
    1355                 1360                 1365             


Ile Ile  Ile Lys Gly Asp Ala  Gly Pro Pro Gly Ile  Pro Gly Gln 
    1370                 1375                 1380             


Pro Gly  Leu Lys Gly Leu Pro  Gly Pro Gln Gly Pro  Gln Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Thr Gly Pro Pro  Gly Asp Pro Gly Arg  Asn Gly Leu 
    1400                 1405                 1410             


Pro Gly  Phe Asp Gly Ala Gly  Gly Arg Lys Gly Asp  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Gln Pro Gly Thr Arg  Gly Leu Asp Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Thr  Ser Ser Val 
    1445                 1450                 1455             


Ala His  Gly Phe Leu Ile Thr  Arg His Ser Gln Thr  Thr Asp Ala 
    1460                 1465                 1470             


Pro Gln  Cys Pro Gln Gly Thr  Leu Gln Val Tyr Glu  Gly Phe Ser 
    1475                 1480                 1485             


Leu Leu  Tyr Val Gln Gly Asn  Lys Arg Ala His Gly  Gln Asp Leu 
    1490                 1495                 1500             


Gly Thr  Ala Gly Ser Cys Leu  Arg Arg Phe Ser Thr  Met Pro Phe 
    1505                 1510                 1515             


Met Phe  Cys Asn Ile Asn Asn  Val Cys Asn Phe Ala  Ser Arg Asn 
    1520                 1525                 1530             


Asp Tyr  Ser Tyr Trp Leu Ser  Thr Pro Glu Pro Met  Pro Met Ser 
    1535                 1540                 1545             


Met Gln  Pro Leu Lys Gly Gln  Ser Ile Gln Pro Phe  Ile Ser Arg 
    1550                 1555                 1560             


Cys Ala  Val Cys Glu Ala Pro  Ala Val Val Ile Ala  Val His Ser 
    1565                 1570                 1575             


Gln Thr  Ile Gln Ile Pro His  Cys Pro Gln Gly Trp  Asp Ser Leu 
    1580                 1585                 1590             


Trp Ile  Gly Tyr Ser Phe Met  Met His Thr Ser Ala  Gly Ala Glu 
    1595                 1600                 1605             


Gly Ser  Gly Gln Ala Leu Ala  Ser Pro Gly Ser Cys  Leu Glu Glu 
    1610                 1615                 1620             


Phe Arg  Ser Ala Pro Phe Ile  Glu Cys His Gly Arg  Gly Thr Cys 
    1625                 1630                 1635             


Asn Tyr  Tyr Ala Asn Ser Tyr  Ser Phe Trp Leu Ala  Thr Val Asp 
    1640                 1645                 1650             


Val Ser  Asp Met Phe Ser Lys  Pro Gln Ser Glu Thr  Leu Lys Ala 
    1655                 1660                 1665             


Gly Asp  Leu Arg Thr Arg Ile  Ser Arg Cys Gln Val  Cys Met Lys 
    1670                 1675                 1680             


Arg Thr  
    1685 


<210>  6
<211>  1691
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Ile Asn Lys Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr 
1               5                   10                  15      


Glu Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly 
            20                  25                  30          


Gly Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala 
        35                  40                  45              


Arg Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln 
    50                  55                  60                  


Gly Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly 
65                  70                  75                  80  


Phe Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro 
                85                  90                  95      


Met Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro 
            100                 105                 110         


Gly Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly 
        115                 120                 125             


Thr Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu 
    130                 135                 140                 


Leu Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro 
145                 150                 155                 160 


Val Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu 
                165                 170                 175     


Pro Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro 
            180                 185                 190         


Gly Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly 
        195                 200                 205             


Pro Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln 
    210                 215                 220                 


Gly Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly 
225                 230                 235                 240 


Pro Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly 
                245                 250                 255     


Lys Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu 
            260                 265                 270         


Arg Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly 
        275                 280                 285             


Glu Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro 
    290                 295                 300                 


Met Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys 
305                 310                 315                 320 


Gly Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly 
                325                 330                 335     


Gln Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile 
            340                 345                 350         


Asp Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Asp Pro Gly 
        355                 360                 365             


Leu Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro 
    370                 375                 380                 


Ser Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu 
385                 390                 395                 400 


Gly Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly 
                405                 410                 415     


Arg Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu 
        435                 440                 445             


Thr Leu His Asn Lys Glu Ala Gly Phe Pro Gly Leu Arg Gly Glu Gln 
    450                 455                 460                 


Gly Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly 
465                 470                 475                 480 


Phe Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys 
            500                 505                 510         


Gly Ala Arg Gly Asp Gln Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly 
        515                 520                 525             


Ala Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys 
    530                 535                 540                 


Lys Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg 
545                 550                 555                 560 


Gly Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly 
                565                 570                 575     


Lys Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp 
            580                 585                 590         


Gly Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly 
        595                 600                 605             


Glu Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro 
    610                 615                 620                 


Gly Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly 
625                 630                 635                 640 


Leu Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro 
                645                 650                 655     


Cys Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly 
        675                 680                 685             


Gln Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu 
    690                 695                 700                 


Val His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys 
705                 710                 715                 720 


Gly Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly 
                725                 730                 735     


Met Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp 
            740                 745                 750         


Ile Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly 
        755                 760                 765             


Leu Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu 
    770                 775                 780                 


Lys Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg 
785                 790                 795                 800 


Gly Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly 
                805                 810                 815     


Ser Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala 
            820                 825                 830         


Pro Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg 
        835                 840                 845             


Gly Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly 
    850                 855                 860                 


Leu Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser 
865                 870                 875                 880 


Pro Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys 
                885                 890                 895     


Gly Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly 
            900                 905                 910         


Leu Pro Gly Ile Ser Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser 
        915                 920                 925             


Thr Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys 
    930                 935                 940                 


Gly Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg 
945                 950                 955                 960 


Pro Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser 
                965                 970                 975     


Ala Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala 
            980                 985                 990         


Gly Arg Pro Gly Pro Pro Gly Leu  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Ile Ile  Lys Gly Val Ser Gly  Lys Pro Gly Pro Pro  Gly Phe Met 
    1010                 1015                 1020             


Gly Ile  Arg Gly Leu Pro Gly  Leu Lys Gly Ser Ser  Gly Ile Thr 
    1025                 1030                 1035             


Gly Phe  Pro Gly Met Pro Gly  Glu Ser Gly Ser Gln  Gly Ile Arg 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Ala Ser Gly Leu Pro  Gly Leu Lys 
    1055                 1060                 1065             


Gly Asp  Asn Gly Gln Thr Val  Glu Ile Ser Gly Ser  Pro Gly Pro 
    1070                 1075                 1080             


Lys Gly  Gln Pro Gly Glu Ser  Gly Phe Lys Gly Thr  Lys Gly Arg 
    1085                 1090                 1095             


Asp Gly  Leu Ile Gly Asn Ile  Gly Phe Pro Gly Lys  Lys Gly Glu 
    1100                 1105                 1110             


Asp Gly  Lys Val Gly Val Ser  Gly Asp Val Gly Leu  Pro Gly Ala 
    1115                 1120                 1125             


Pro Gly  Phe Pro Gly Val Ala  Gly Met Arg Gly Glu  Pro Gly Leu 
    1130                 1135                 1140             


Pro Gly  Ser Ser Gly His Gln  Gly Ala Ile Gly Pro  Leu Gly Ser 
    1145                 1150                 1155             


Pro Gly  Leu Ile Gly Pro Lys  Gly Phe Pro Gly Phe  Pro Gly Leu 
    1160                 1165                 1170             


His Gly  Leu Asn Gly Leu Pro  Gly Thr Lys Gly Thr  His Gly Thr 
    1175                 1180                 1185             


Pro Gly  Pro Ser Ile Thr Gly  Val Pro Gly Pro Ala  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly Ile Gly  Ile Gly Ala 
    1205                 1210                 1215             


Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys Gly Asp  Arg Gly Phe 
    1220                 1225                 1230             


Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro Gly Ala  Pro Gly Ile 
    1235                 1240                 1245             


Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro Gly Asp  Pro Gly Arg 
    1250                 1255                 1260             


Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro Gly Pro  Ala Gly Pro 
    1265                 1270                 1275             


Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln Gly Asp  Thr Gly Asp 
    1280                 1285                 1290             


Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys Gly Pro  Lys Gly Asp 
    1295                 1300                 1305             


Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro Gly Glu  Leu Gly Leu 
    1310                 1315                 1320             


Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met Gly Thr  Pro Gly Lys 
    1325                 1330                 1335             


Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro Gly Met  Lys Gly Lys 
    1340                 1345                 1350             


Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln Gly His  Pro Gly Gln 
    1355                 1360                 1365             


Thr Pro  Thr Ala Glu Ala Val  Gln Val Pro Pro Gly  Pro Leu Gly 
    1370                 1375                 1380             


Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu Thr Gly  Asp Pro Gly 
    1385                 1390                 1395             


Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser Lys Gly  Leu Pro Gly 
    1400                 1405                 1410             


Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu Gln Gly  Pro Pro Gly 
    1430                 1435                 1440             


Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro Phe Gly  Met Pro Gly 
    1445                 1450                 1455             


Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr Thr Leu  Val Lys His 
    1460                 1465                 1470             


Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro Ile Gly  Met Ser Gln 
    1475                 1480                 1485             


Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val Glu Gly  Gln Glu Lys 
    1490                 1495                 1500             


Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly Ser Cys  Leu Pro Arg 
    1505                 1510                 1515             


Phe Ser  Thr Met Pro Phe Ile  Tyr Cys Asn Ile Asn  Glu Val Cys 
    1520                 1525                 1530             


His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr Trp Leu  Ser Thr Thr 
    1535                 1540                 1545             


Ala Pro  Ile Pro Met Met Pro  Val Ser Gln Thr Gln  Ile Pro Gln 
    1550                 1555                 1560             


Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala Pro Ser  Gln Ala Ile 
    1565                 1570                 1575             


Ala Val  His Ser Gln Asp Ile  Thr Ile Pro Gln Cys  Pro Leu Gly 
    1580                 1585                 1590             


Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe Leu Met  His Thr Ala 
    1595                 1600                 1605             


Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu Val Ser  Pro Gly Ser 
    1610                 1615                 1620             


Cys Leu  Glu Asp Phe Arg Ala  Thr Pro Phe Ile Glu  Cys Ser Gly 
    1625                 1630                 1635             


Ala Arg  Gly Thr Cys His Tyr  Phe Ala Asn Lys Tyr  Ser Phe Trp 
    1640                 1645                 1650             


Leu Thr  Thr Val Glu Glu Arg  Gln Gln Phe Gly Glu  Leu Pro Val 
    1655                 1660                 1665             


Ser Glu  Thr Leu Lys Ala Gly  Gln Leu His Thr Arg  Val Ser Arg 
    1670                 1675                 1680             


Cys Gln  Val Cys Met Lys Ser  Leu 
    1685                 1690     


<210>  7
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Phe Leu Val Thr Arg His Ser Gln Thr Ile Asp Asp Pro Gln Cys 
1               5                   10                  15      


Pro Ser Gly Thr Lys Ile Leu Tyr His Gly Tyr Ser Leu Leu Tyr Val 
            20                  25                  30          


Gln Gly Asn Glu Arg Ala His Gly Gln Asp Leu Gly Thr Ala Gly Ser 
        35                  40                  45              


Cys Leu Arg Lys Phe Ser Thr Met Pro Phe Leu Phe Cys Asn Ile Asn 
    50                  55                  60                  


Asn Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser 
65                  70                  75                  80  


Thr Pro Glu Pro Met Pro Met Ser Met Ala Pro Ile Thr Gly Glu Asn 
                85                  90                  95      


Ile Arg Pro Phe Ile Ser Arg Cys Ala Val Cys Glu Ala Pro Ala Met 
            100                 105                 110         


Val Met Ala Val His Ser Gln Thr Ile Gln Ile Pro Pro Cys Pro Ser 
        115                 120                 125             


Gly Trp Ser Ser Leu Trp Ile Gly Tyr Ser Phe Val Met His Thr Ser 
    130                 135                 140                 


Ala Gly Ala Glu Gly Ser Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys 
145                 150                 155                 160 


Leu Glu Glu Phe Arg Ser Ala Pro Phe Ile Glu Cys His Gly Arg Gly 
                165                 170                 175     


Thr Cys Asn Tyr Tyr Ala Asn Ala Tyr Ser Phe Trp Leu Ala Thr Ile 
            180                 185                 190         


Glu Arg Ser Glu Met Phe Lys Lys Pro Thr Pro Ser Thr Leu Lys Ala 
        195                 200                 205             


Gly Glu Leu Arg Thr His Val Ser Arg Cys Gln Val Cys Met Arg Arg 
    210                 215                 220                 


Thr 
225 


<210>  8
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Tyr Leu Leu Val Lys His Ser Gln Thr Asp Gln Glu Pro Met Cys 
1               5                   10                  15      


Pro Val Gly Met Asn Lys Leu Trp Ser Gly Tyr Ser Leu Leu Tyr Phe 
            20                  25                  30          


Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser 
        35                  40                  45              


Cys Leu Ala Arg Phe Ser Thr Met Pro Phe Leu Tyr Cys Asn Pro Gly 
    50                  55                  60                  


Asp Val Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu Ser 
65                  70                  75                  80  


Thr Thr Ala Pro Leu Pro Met Met Pro Val Ala Glu Asp Glu Ile Lys 
                85                  90                  95      


Pro Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ala Ile Ala Ile 
            100                 105                 110         


Ala Val His Ser Gln Asp Val Ser Ile Pro His Cys Pro Ala Gly Trp 
        115                 120                 125             


Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly 
    130                 135                 140                 


Asp Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu Glu 
145                 150                 155                 160 


Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Asn Gly Gly Arg Gly Thr 
                165                 170                 175     


Cys His Tyr Tyr Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Ile Pro 
            180                 185                 190         


Glu Gln Ser Phe Gln Gly Ser Pro Ser Ala Asp Thr Leu Lys Ala Gly 
        195                 200                 205             


Leu Ile Arg Thr His Ile Ser Arg Cys Gln Val Cys Met Lys Asn Leu 
    210                 215                 220                 


<210>  9
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro Ser Cys 
1               5                   10                  15      


Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser Phe Leu Phe Val 
            20                  25                  30          


Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu Gly Thr Leu Gly Ser 
        35                  40                  45              


Cys Leu Gln Arg Phe Thr Thr Met Pro Phe Leu Phe Cys Asn Val Asn 
    50                  55                  60                  


Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser 
65                  70                  75                  80  


Thr Pro Ala Leu Met Pro Met Asn Met Ala Pro Ile Thr Gly Arg Ala 
                85                  90                  95      


Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly Pro Ala Ile 
            100                 105                 110         


Ala Ile Ala Val His Ser Gln Thr Thr Asp Ile Pro Pro Cys Pro His 
        115                 120                 125             


Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser Phe Ile Met Phe Thr Ser 
    130                 135                 140                 


Ala Gly Ser Glu Gly Thr Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys 
145                 150                 155                 160 


Leu Glu Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys His Gly Arg Gly 
                165                 170                 175     


Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu 
            180                 185                 190         


Asn Pro Glu Arg Met Phe Arg Lys Pro Ile Pro Ser Thr Val Lys Ala 
        195                 200                 205             


Gly Glu Leu Glu Lys Ile Ile Ser Arg Cys Gln Val Cys Met Lys Lys 
    210                 215                 220                 


Arg 
225 


<210>  10
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Phe Leu Leu Val Leu His Ser Gln Thr Asp Gln Glu Pro Thr Cys 
1               5                   10                  15      


Pro Leu Gly Met Pro Arg Leu Trp Thr Gly Tyr Ser Leu Leu Tyr Leu 
            20                  25                  30          


Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu Ala Gly Ser 
        35                  40                  45              


Cys Leu Pro Val Phe Ser Thr Leu Pro Phe Ala Tyr Cys Asn Ile His 
    50                  55                  60                  


Gln Val Cys His Tyr Ala Gln Arg Asn Asp Arg Ser Tyr Trp Leu Ala 
65                  70                  75                  80  


Ser Ala Ala Pro Leu Pro Met Met Pro Leu Ser Glu Glu Ala Ile Arg 
                85                  90                  95      


Pro Tyr Val Ser Arg Cys Ala Val Cys Glu Ala Pro Ala Gln Ala Val 
            100                 105                 110         


Ala Val His Ser Gln Asp Gln Ser Ile Pro Pro Cys Pro Gln Thr Trp 
        115                 120                 125             


Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Gly Ala Gly 
    130                 135                 140                 


Asp Gln Gly Gly Gly Gln Ala Leu Met Ser Pro Gly Ser Cys Leu Glu 
145                 150                 155                 160 


Asp Phe Arg Ala Ala Pro Phe Leu Glu Cys Gln Gly Arg Gln Gly Thr 
                165                 170                 175     


Cys His Phe Phe Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Val Lys 
            180                 185                 190         


Ala Asp Leu Gln Phe Ser Ser Ala Pro Ala Pro Asp Thr Leu Lys Glu 
        195                 200                 205             


Ser Gln Ala Gln Arg Gln Lys Ile Ser Arg Cys Gln Val Cys Val Lys 
    210                 215                 220                 


Tyr Ser 
225     


<210>  11
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Phe Leu Ile Thr Arg His Ser Gln Thr Thr Asp Ala Pro Gln Cys 
1               5                   10                  15      


Pro Gln Gly Thr Leu Gln Val Tyr Glu Gly Phe Ser Leu Leu Tyr Val 
            20                  25                  30          


Gln Gly Asn Lys Arg Ala His Gly Gln Asp Leu Gly Thr Ala Gly Ser 
        35                  40                  45              


Cys Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Cys Asn Ile Asn 
    50                  55                  60                  


Asn Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser 
65                  70                  75                  80  


Thr Pro Glu Pro Met Pro Met Ser Met Gln Pro Leu Lys Gly Gln Ser 
                85                  90                  95      


Ile Gln Pro Phe Ile Ser Arg Cys Ala Val Cys Glu Ala Pro Ala Val 
            100                 105                 110         


Val Ile Ala Val His Ser Gln Thr Ile Gln Ile Pro His Cys Pro Gln 
        115                 120                 125             


Gly Trp Asp Ser Leu Trp Ile Gly Tyr Ser Phe Met Met His Thr Ser 
    130                 135                 140                 


Ala Gly Ala Glu Gly Ser Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys 
145                 150                 155                 160 


Leu Glu Glu Phe Arg Ser Ala Pro Phe Ile Glu Cys His Gly Arg Gly 
                165                 170                 175     


Thr Cys Asn Tyr Tyr Ala Asn Ser Tyr Ser Phe Trp Leu Ala Thr Val 
            180                 185                 190         


Asp Val Ser Asp Met Phe Ser Lys Pro Gln Ser Glu Thr Leu Lys Ala 
        195                 200                 205             


Gly Asp Leu Arg Thr Arg Ile Ser Arg Cys Gln Val Cys Met Lys Arg 
    210                 215                 220                 


Thr 
225 


<210>  12
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Tyr Thr Leu Val Lys His Ser Gln Ser Glu Gln Val Pro Pro Cys 
1               5                   10                  15      


Pro Ile Gly Met Ser Gln Leu Trp Val Gly Tyr Ser Leu Leu Phe Val 
            20                  25                  30          


Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Phe Ala Gly Ser 
        35                  40                  45              


Cys Leu Pro Arg Phe Ser Thr Met Pro Phe Ile Tyr Cys Asn Ile Asn 
    50                  55                  60                  


Glu Val Cys His Tyr Ala Arg Arg Asn Asp Lys Ser Tyr Trp Leu Ser 
65                  70                  75                  80  


Thr Thr Ala Pro Ile Pro Met Met Pro Val Ser Gln Thr Gln Ile Pro 
                85                  90                  95      


Gln Tyr Ile Ser Arg Cys Ser Val Cys Glu Ala Pro Ser Gln Ala Ile 
            100                 105                 110         


Ala Val His Ser Gln Asp Ile Thr Ile Pro Gln Cys Pro Leu Gly Trp 
        115                 120                 125             


Arg Ser Leu Trp Ile Gly Tyr Ser Phe Leu Met His Thr Ala Ala Gly 
    130                 135                 140                 


Ala Glu Gly Gly Gly Gln Ser Leu Val Ser Pro Gly Ser Cys Leu Glu 
145                 150                 155                 160 


Asp Phe Arg Ala Thr Pro Phe Ile Glu Cys Ser Gly Ala Arg Gly Thr 
                165                 170                 175     


Cys His Tyr Phe Ala Asn Lys Tyr Ser Phe Trp Leu Thr Thr Val Glu 
            180                 185                 190         


Glu Arg Gln Gln Phe Gly Glu Leu Pro Val Ser Glu Thr Leu Lys Ala 
        195                 200                 205             


Gly Gln Leu His Thr Arg Val Ser Arg Cys Gln Val Cys Met Lys Ser 
    210                 215                 220                 


Leu 
225 


