                         SEQUENCE LISTING

<110>  Crown Bioscience (Taicang) Inc.
       Zha, Jiping
       Qiu, Junzhuan
       Sun, Ziyong
 
<120>  ANTI PD-1 ANTIBODIES

<130>  CRBI-006/01WO

<150>  PCT/CN2014/082721
<151>  2014-07-22

<160>  153   

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  1
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg                                       450


<210>  2
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  3
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  3
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg ggtaccagat ctagaggctg caaaccctgt      480

atctgcacag tgcccgaggt gagctccgtg ttcatctttc cccccaagcc caaggacgtg      540

ctgaccatca cactcacacc caaggtcacc tgcgtggtcg tggacatctc caaggacgac      600

cccgaagtcc agttcagctg gttcgtggac gacgtggagg tgcacaccgc tcagacccaa      660

cccagagagg agcagtttaa ctccaccttc aggtccgtgt ccgagctccc catcatgcac      720

caggactggc tgaatggcaa ggagttcaag tgcagggtga actccgctgc tttccccgcc      780

cccattgaga agaccatctc caagaccaag ggaaggccca aggcccccca ggtgtacacc      840

attccccctc ccaaggagca gatggccaag gacaaggtgt ccctgacctg tatgatcacc      900

gacttctttc ccgaggacat caccgtcgaa tggcagtgga acggccagcc cgccgagaac      960

tataagaaca cccaacccat catggacacc gacggcagct acttcgtgta tagcaagctc     1020

aacgtgcaga agagcaactg ggaagccgga aataccttca cctgctccgt cctgcacgag     1080

ggcctgcaca accaccatac cgaaaagagc ctgagccaca gccccggaaa gtaa           1134


<210>  4
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Thr Arg Ser Arg Gly Cys Lys Pro Cys 
145                 150                 155                 160 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
        195                 200                 205             


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
    210                 215                 220                 


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
                245                 250                 255     


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
            260                 265                 270         


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
        275                 280                 285             


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
    290                 295                 300                 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
305                 310                 315                 320 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
                325                 330                 335     


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
            340                 345                 350         


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
        355                 360                 365             


Lys Ser Leu Ser His Ser Pro Gly Lys 
    370                 375         


<210>  5
<211>  1164
<212>  DNA
<213>  Homo sapiens

<400>  5
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagccg gccagttcca aaccctggtg ggtaccagat ctagagagcc caaatcttct      480

gacaaaactc acacatgccc accgtgccca gcacctgaat tcgagggtgc accgtcagtc      540

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggactcc tgaggtcaca      600

tgcgtggtgg tggacgtaag ccacgaagac cctgaggtca agttcaactg gtacgtggac      660

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      720

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      780

tgcaaggtct ccaacaaagc cctcccaacc cccatcgaga aaaccatctc caaagccaaa      840

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      900

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc caagcgacat cgccgtggag      960

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1020

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1080

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1140

ctctccctgt ctccgggtaa atga                                            1164


<210>  6
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Thr Arg Ser Arg Glu Pro Lys Ser Ser 
145                 150                 155                 160 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
                165                 170                 175     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            180                 185                 190         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        195                 200                 205             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    210                 215                 220                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
225                 230                 235                 240 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                245                 250                 255     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Thr Pro Ile 
            260                 265                 270         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        275                 280                 285             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    290                 295                 300                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
305                 310                 315                 320 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                325                 330                 335     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            340                 345                 350         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        355                 360                 365             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    370                 375                 380                 


Pro Gly Lys 
385         


<210>  7
<211>  1128
<212>  DNA
<213>  Cynomolgous sp.

<400>  7
ccaggatggt tcttagaatc cccggacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcctgg tgaccgaagg agacaacgcc accttcacct gcagcttctc caacgcctcg      120

gagagcttcg tgctgaactg gtaccgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      420

aggccagctg gccagttcca agccggtacc agatctagag gctgcaaacc ctgtatctgc      480

acagtgcccg aggtgagctc cgtgttcatc tttcccccca agcccaagga cgtgctgacc      540

atcacactca cacccaaggt cacctgcgtg gtcgtggaca tctccaagga cgaccccgaa      600

gtccagttca gctggttcgt ggacgacgtg gaggtgcaca ccgctcagac ccaacccaga      660

gaggagcagt ttaactccac cttcaggtcc gtgtccgagc tccccatcat gcaccaggac      720

tggctgaatg gcaaggagtt caagtgcagg gtgaactccg ctgctttccc cgcccccatt      780

gagaagacca tctccaagac caagggaagg cccaaggccc cccaggtgta caccattccc      840

cctcccaagg agcagatggc caaggacaag gtgtccctga cctgtatgat caccgacttc      900

tttcccgagg acatcaccgt cgaatggcag tggaacggcc agcccgccga gaactataag      960

aacacccaac ccatcatgga caccgacggc agctacttcg tgtatagcaa gctcaacgtg     1020

cagaagagca actgggaagc cggaaatacc ttcacctgct ccgtcctgca cgagggcctg     1080

cacaaccacc ataccgaaaa gagcctgagc cacagccccg gaaagtaa                  1128


<210>  8
<211>  375
<212>  PRT
<213>  Cynomolgous sp.

<400>  8

Pro Gly Trp Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Leu Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Ala Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Ala Gly Thr Arg Ser Arg Gly Cys Lys Pro Cys Ile Cys 
145                 150                 155                 160 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
        195                 200                 205             


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
    210                 215                 220                 


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
            260                 265                 270         


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
        275                 280                 285             


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
    290                 295                 300                 


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
305                 310                 315                 320 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
                325                 330                 335     


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
            340                 345                 350         


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
        355                 360                 365             


Leu Ser His Ser Pro Gly Lys 
    370                 375 


<210>  9
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  9
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660


<210>  10
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  11
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  11
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

catcatcacc accatcacta a                                                681


<210>  12
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg His His His His 
    210                 215                 220                 


His His 
225     


<210>  13
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  13
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

ggtaccagat ctagaggctg caaaccctgt atctgcacag tgcccgaggt gagctccgtg      720

ttcatctttc cccccaagcc caaggacgtg ctgaccatca cactcacacc caaggtcacc      780

tgcgtggtcg tggacatctc caaggacgac cccgaagtcc agttcagctg gttcgtggac      840

gacgtggagg tgcacaccgc tcagacccaa cccagagagg agcagtttaa ctccaccttc      900

aggtccgtgt ccgagctccc catcatgcac caggactggc tgaatggcaa ggagttcaag      960

tgcagggtga actccgctgc tttccccgcc cccattgaga agaccatctc caagaccaag     1020

ggaaggccca aggcccccca ggtgtacacc attccccctc ccaaggagca gatggccaag     1080

gacaaggtgt ccctgacctg tatgatcacc gacttctttc ccgaggacat caccgtcgaa     1140

tggcagtgga acggccagcc cgccgagaac tataagaaca cccaacccat catggacacc     1200

gacggcagct acttcgtgta tagcaagctc aacgtgcaga agagcaactg ggaagccgga     1260

aataccttca cctgctccgt cctgcacgag ggcctgcaca accaccatac cgaaaagagc     1320

ctgagccaca gccccggaaa gtaa                                            1344


<210>  14
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Gly Thr Arg Ser 
    210                 215                 220                 


Arg Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
            340                 345                 350         


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
    370                 375                 380                 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
                405                 410                 415     


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445         


<210>  15
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  15
tttactgtca cggttcccaa ggacctatat gtggtagagt atggtagcaa tatgacaatt       60

gaatgcaaat tcccagtaga aaaacaatta gacctggctg cactaattgt ctattgggaa      120

atggaggata agaacattat tcaatttgtg catggagagg aagacctgaa ggttcagcat      180

agtagctaca gacagagggc ccggctgttg aaggaccagc tctccctggg aaatgctgca      240

cttcagatca cagatgtgaa attgcaggat gcaggggtgt accgctgcat gatcagctat      300

ggtggtgccg actacaagcg aattactgtg aaagtcaatg ccccatacaa caaaatcaac      360

caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag      420

ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag      480

accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga      540

atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa      600

aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg      660

ggtaccagat ctagagagcc caaatcttct gacaaaactc acacatgccc accgtgccca      720

gcacctgaat tcgagggtgc accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggactcc tgaggtcaca tgcgtggtgg tggacgtaag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaacc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc caagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga           1374


<210>  16
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Gly Thr Arg Ser 
    210                 215                 220                 


Arg Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Phe Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Thr Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  17
<211>  354
<212>  DNA
<213>  Mus sp.

<400>  17
gaagtgaagt tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agttatggca tgtcttggct tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc atgagtggtg ggggtcgtga catctactat      180

ccagacagta tgaaggggcg attcaccatc tccagagaca atgccaagaa caacctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccttat attactgtgc aagacaatat      300

tacgacgact ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210>  18
<211>  118
<212>  PRT
<213>  Mus sp.

<400>  18

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Leu Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Met Ser Gly Gly Gly Arg Asp Ile Tyr Tyr Pro Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Tyr Tyr Asp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  19
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  19

Ser Tyr Gly Met Ser 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  20

Thr Met Ser Gly Gly Gly Arg Asp Ile Tyr Tyr Pro Asp Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  21

Gln Tyr Tyr Asp Asp Trp Phe Ala Tyr 
1               5                   


<210>  22
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  22
gatattgtgc tcacacagac tccagccacc ctgtctgtga ctccaggaga tagcgtcagt       60

ctctcctgca gggccagcca aagtattagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagac ttcactctca atatcaacag tgtggagacc      240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgg                                             324


<210>  23
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  23

Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  24
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  24

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  25

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  26

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  27
<211>  366
<212>  DNA
<213>  Mus sp.

<400>  27
caggtgcagc tgaagcagtc aggacctggc ctggtgcagc cctcacagaa cctgtccgtc       60

acctgcacag tctctggttt ctcattaact acctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggggtg atatggagtg gtggaagcac agactataat      180

gcggctttca tatccagact gaccatcagc aaggacaatg ccaggagcca agttttcttt      240

aaaatgaaca gtctgcaagt taatgacaca gccatgtatt actgtgccag agagaaaagc      300

gtctatggta attacgtggg ggctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  28
<211>  122
<212>  PRT
<213>  Mus sp.

<400>  28

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Asn Leu Ser Val Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ala Arg Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Val Asn Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Lys Ser Val Tyr Gly Asn Tyr Val Gly Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  29

Thr Tyr Gly Val His 
1               5   


<210>  30
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  30

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  31
<211>  14
<212>  PRT
<213>  Mus sp.

<400>  31

Glu Lys Ser Val Tyr Gly Asn Tyr Val Gly Ala Met Asp Tyr 
1               5                   10                  


<210>  32
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  32
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcgggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt gatgatgtag cttggtacca acagaagcca      120

gggcagtctc ctaaactgct gatatactat gcattcaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcagtct      240

gaagacctgg cagtttattt ctgtcagcag gattatcgct ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  33
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  33

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asp Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Phe Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Arg Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  34
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  34

Lys Ala Ser Gln Ser Val Ser Asp Asp Val Ala 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  35

Tyr Ala Phe Asn Arg Tyr Thr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  36

Gln Gln Asp Tyr Arg Ser Pro Trp Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  37

Gln Gln Asp Tyr Arg Ser Pro Trp Thr 
1               5                   


<210>  38
<211>  354
<212>  DNA
<213>  Mus sp.

<400>  38
gaagtgaagt tggtggagtc ggggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtggag cctctggatt cactttcagt agttatggca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtagaga tatttattat      180

ccagacagtg tgaaggggcg actcaccatc tccagagaca atgccaagaa caacctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccttgt attactgtgt aagacaatat      300

tacgacgact ggttcgctta ttggggccaa gggactctgg tcactgtctc tgca            354


<210>  39
<211>  118
<212>  PRT
<213>  Mus sp.

<400>  39

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Asp Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gln Tyr Tyr Asp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  40
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  40

Ser Tyr Gly Met Ser 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  41

Thr Ile Ser Gly Gly Gly Arg Asp Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  42

Gln Tyr Tyr Asp Asp Trp Phe Ala Tyr 
1               5                   


<210>  43
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  43
gacattgtgc tgacacagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt       60

ctttcctgca gggccagcca aagtattagc aacgaccttc actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gtttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacggat ttcactctca gtatcaacag tgtggagact      240

gaggattttg gaatgtattt ctgtcaacag agtgacagct ggccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgg                                             324


<210>  44
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  44

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asp Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  45
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  45

Arg Ala Ser Gln Ser Ile Ser Asn Asp Leu His 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  46

Tyr Val Ser Gln Ser Ile Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  47

Gln Gln Ser Asp Ser Trp Pro Leu Thr 
1               5                   


<210>  48
<211>  360
<212>  DNA
<213>  Mus sp.

<400>  48
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa accaactgga gtggatggcc tacattagtt acagtggtta cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagatctctt      300

gactatgatt acggaactat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  49
<211>  120
<212>  PRT
<213>  Mus sp.

<400>  49

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gln Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  50
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  50

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  51
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  51

Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  52
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  52

Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr 
1               5                   10      


<210>  53
<211>  321
<212>  DNA
<213>  Mus sp.

<400>  53
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacctgca gggccaactc aagtgtaagt tccatgcact ggtaccagca gaagccagga      120

tcctcccccg aaccctggat ttatgccatt tccaacctgg cttttggagt ccctactcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttatttctg ccagcagtgg agtagtagac cacccacgtt cggagggggg      300

accaagctgg aaataaaacg g                                                321


<210>  54
<211>  107
<212>  PRT
<213>  Mus sp.

<400>  54

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Asn Ser Ser Val Ser Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Glu Pro Trp Ile Tyr 
        35                  40                  45              


Ala Ile Ser Asn Leu Ala Phe Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Arg Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  55
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  55

Arg Ala Asn Ser Ser Val Ser Ser Met His 
1               5                   10  


<210>  56
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  56

Ala Ile Ser Asn Leu Ala Phe 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  57

Gln Gln Trp Ser Ser Arg Pro Pro Thr 
1               5                   


<210>  58
<211>  351
<212>  DNA
<213>  Mus sp.

<400>  58
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cgctttccgt agctatgaca tgtcttgggt tcgccagact      120

ccggagaaga tcctggagtg ggtcgcaacc attagtggtg gtggtagtta cacctactat      180

caagacagtg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccttgt attactgtgc aagcccctat      300

ggcccctact ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  59
<211>  117
<212>  PRT
<213>  Mus sp.

<400>  59

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Ile Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  60
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  60

Ser Tyr Asp Met Ser 
1               5   


<210>  61
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  61

Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  62

Pro Tyr Gly Pro Tyr Phe Asp Tyr 
1               5               


<210>  63
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  63
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacgattacc       60

atcacttgcc atgccagtca gagcattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactatt gatctatagg gcttccaact tgcacacagg cgtcccatca      180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gacgacattg ccacttacta ctgtcaacag ggtcaaagtt atccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  64
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  64

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Ser Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  65
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  65

His Ala Ser Gln Ser Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  66
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  66

Ala Ser Asn Leu His Thr 
1               5       


<210>  67
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  67

Gln Gln Gly Gln Ser Tyr Pro Trp Thr 
1               5                   


<210>  68
<211>  360
<212>  DNA
<213>  Mus sp.

<400>  68
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa accaactgga gtggatggcc tacattagct acagtggtta cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaggaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagatctctt      300

gactatgatt acggaactat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  69
<211>  120
<212>  PRT
<213>  Mus sp.

<400>  69

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gln Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Arg Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  6
<212>  PRT
<213>  Mus sp.

<400>  70

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  71
<211>  16
<212>  PRT
<213>  Mus sp.

<400>  71

Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  72
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  72

Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr 
1               5                   10      


<210>  73
<211>  321
<212>  DNA
<213>  Mus sp.

<400>  73
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacctgca gggccaactc aagtgtaagt tccatgcact ggtaccaaca gaagccagga      120

tcctcccccg aaccctggat ttatgccatt tccaacctgg cttttggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttatttctg ccagcaatgg aatagtagac cacccacgtt cggagggggg      300

accaagctgg aaataaaacg g                                                321


<210>  74
<211>  107
<212>  PRT
<213>  Mus sp.

<400>  74

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Asn Ser Ser Val Ser Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Glu Pro Trp Ile Tyr 
        35                  40                  45              


Ala Ile Ser Asn Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Asn Ser Arg Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  75
<211>  10
<212>  PRT
<213>  Mus sp.

<400>  75

Arg Ala Asn Ser Ser Val Ser Ser Met His 
1               5                   10  


<210>  76
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  76

Ala Ile Ser Asn Leu Ala Phe 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  77

Gln Gln Trp Asn Ser Arg Pro Pro Thr 
1               5                   


<210>  78
<211>  351
<212>  DNA
<213>  Mus sp.

<400>  78
gaagtgaaac tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgttcag cctctggatt cagtttcagt tactatgaca tgtcttgggt tcggcagact      120

ccggagaagg gactggagtg ggtcgcaacc attagtggtg gtggtagaaa tacctatttt      180

atagacagtg tgaaggggcg attcaccatc tccagagaca atgtcaagaa caacctgtat      240

ctgctaatga gcagtctgag gtctgaggat acggccttgt attactgtgc aagcccctat      300

gagggggctg tggacttctg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  79
<211>  117
<212>  PRT
<213>  Mus sp.

<400>  79

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ser Ala Ser Gly Phe Ser Phe Ser Tyr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Asn Thr Tyr Phe Ile Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Leu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Glu Gly Ala Val Asp Phe Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  80
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  80

Tyr Tyr Asp Met Ser 
1               5   


<210>  81
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  81

Thr Ile Ser Gly Gly Gly Arg Asn Thr Tyr Phe Ile Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  82

Pro Tyr Glu Gly Ala Val Asp Phe 
1               5               


<210>  83
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  83
gacattgtga tgacccagtc tcacaaagtc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtggat aatgctgtag cctggtatca acagaatccc      120

ggacaatctc ctaaactact gattaagtgg gcatccaccc gacaccatgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcac tgtgcaatct      240

gaagacttgg cagatttttt ctgtcagcaa tatagcacct ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  84
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  84

Asp Ile Val Met Thr Gln Ser His Lys Val Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Asn Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Trp Ala Ser Thr Arg His His Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Phe Phe Cys Gln Gln Tyr Ser Thr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  85
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  85

Lys Ala Ser Gln Asp Val Asp Asn Ala Val Ala 
1               5                   10      


<210>  86
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  86

Trp Ala Ser Thr Arg His His 
1               5           


<210>  87
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  87

Gln Gln Tyr Ser Thr Phe Pro Tyr Thr 
1               5                   


<210>  88
<211>  354
<212>  DNA
<213>  Mus sp.

<400>  88
gaagtgaagt tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtcgtga cacctactat      180

ctagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caacctgtat      240

ttgcaaatga gcagtctgag gtctgaggac acggccttgt attactgtgt gagacagtat      300

tacgacgact ggtttgctta ctggggccaa gggactctgg tctctaactc tgca            354


<210>  89
<211>  118
<212>  PRT
<213>  Mus sp.

<400>  89

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gln Tyr Tyr Asp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Ser Asn Ser Ala 
        115             


<210>  90
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  90

Ser Tyr Gly Met Ser 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  91

Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  92

Gln Tyr Tyr Asp Asp Trp Phe Ala Tyr 
1               5                   


<210>  93
<211>  321
<212>  DNA
<213>  Mus sp.

<400>  93
gatattgtgc tcacccagac tccagccacc ctttctgtga ctccaggaga tagtgtcagt       60

ctttcctgca gggccagcca aagtcttagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggccgctcac gttcggtgct      300

gggaccaagc tggagatgaa a                                                321


<210>  94
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  94

Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105             


<210>  95
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  95

Arg Ala Ser Gln Ser Leu Ser Asn Asn Leu His 
1               5                   10      


<210>  96
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  96

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  97

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  98
<211>  360
<212>  DNA
<213>  Mus sp.

<400>  98
caggtccagc tgcagcagtc tggagatgag ctggtaaggc ctgggacttc agtgaagatg       60

tcctgcaagg ctgctggata caccttcact aacaactgga taggttgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagat ttctaccctg gaggtggtta tactaactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgccatct attactgtgc aagaggctac      300

ggtactaact actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  99
<211>  120
<212>  PRT
<213>  Mus sp.

<400>  99

Gln Val Gln Leu Gln Gln Ser Gly Asp Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Thr Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  100
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  100

Asn Asn Trp Ile Gly 
1               5   


<210>  101
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  101

Asp Phe Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  102

Gly Tyr Gly Thr Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10      


<210>  103
<211>  324
<212>  DNA
<213>  Mus sp.

<400>  103
aatattgtga tgacccagac tcccaaaatc ctgtttatat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca acagaagcca      120

gggcagtctc ctaaactgct gatatactat gcattcactc gctacattgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccttacac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  104
<211>  108
<212>  PRT
<213>  Mus sp.

<400>  104

Asn Ile Val Met Thr Gln Thr Pro Lys Ile Leu Phe Ile Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Phe Thr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  105
<211>  11
<212>  PRT
<213>  Mus sp.

<400>  105

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  106
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  106

Tyr Ala Phe Thr Arg Tyr Ile 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Mus sp.

<400>  107

Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  108
<211>  342
<212>  DNA
<213>  Mus sp.

<400>  108
cagatccact tggtgcagtc tggacctgaa ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactttggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataagtggct acactaggga gccaacatat      180

gctgctgact tcaagggacg atttgccatc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acgacctcaa aaatgaagac atggctacat atttctgtgc aagagacgtt      300

tttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  109
<211>  114
<212>  PRT
<213>  Mus sp.

<400>  109

Gln Ile His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  110
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  110

Asn Phe Gly Met Asn 
1               5   


<210>  111
<211>  17
<212>  PRT
<213>  Mus sp.

<400>  111

Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  5
<212>  PRT
<213>  Mus sp.

<400>  112

Asp Val Phe Asp Tyr 
1               5   


<210>  113
<211>  333
<212>  DNA
<213>  Mus sp.

<400>  113
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atttcctgca gagccagtga aagtgttgat aattatggct atagttttat gaactggttc      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacaa acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat ttctgtcagc aaagtaatgc ggatccgacg      300

ttcggtggag gcaccaacct ggaaatcaaa cgg                                   333


<210>  114
<211>  111
<212>  PRT
<213>  Mus sp.

<400>  114

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Tyr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asn Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Phe Cys Gln Gln Ser Asn 
                85                  90                  95      


Ala Asp Pro Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg 
            100                 105                 110     


<210>  115
<211>  15
<212>  PRT
<213>  Mus sp.

<400>  115

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Tyr Ser Phe Met Asn 
1               5                   10                  15  


<210>  116
<211>  7
<212>  PRT
<213>  Mus sp.

<400>  116

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  117
<211>  8
<212>  PRT
<213>  Mus sp.

<400>  117

Gln Gln Ser Asn Ala Asp Pro Thr 
1               5               


<210>  118
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A4-IgG1 D265A chimeric antibody heavy chain full length DNA 
       sequence

<400>  118
cagatccact tggtgcagtc tggacctgaa ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactttggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataagtggct acactaggga gccaacatat      180

gctgctgact tcaagggacg atttgccatc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acgacctcaa aaatgaagac atggctacat atttctgtgc aagagacgtt      300

tttgactact ggggccaagg caccactctc acagtctcga gcgcctccac taagggccca      360

tccgtgttcc ctctggcacc ctccagcaag agcacaagcg gaggcaccgc cgcactgggc      420

tgcctcgtga aggactactt cccagaaccc gtgaccgtca gctggaatag cggcgctctg      480

accagcggag tccacacttt ccccgcagtg ctgcagtcca gcggcctgta cagcctgagc      540

agcgtggtca ctgtgccaag cagcagcctg ggcactcaga cctacatctg caacgtcaac      600

cacaagccca gcaacacaaa ggtggacaag aaggtcgagc ccaagtcctg cgataagacc      660

cacacctgcc ctccatgtcc cgcccccgag ctgctgggag gacccagcgt cttcctgttt      720

ccccccaagc caaaggacac cctgatgatc agcaggaccc ccgaagtgac ctgcgtcgtg      780

gtggccgtga gccacgaaga tcccgaggtg aagttcaact ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagacaaa acccagggag gagcagtatg ccagcaccta cagggtcgtg      900

agcgtcctga ccgtgctgca ccaagactgg ctgaacggca aggagtataa gtgcaaggtg      960

agcaacaagg cactgcccgc ccccatcgag aagaccattt ccaaggccaa ggggcaacct     1020

agggagccac aggtctacac tctgccccct agcagggacg agctgaccaa gaaccaggtc     1080

tccctgactt gcctggtgaa ggggttttat cccagcgaca tcgccgtcga gtgggagagc     1140

aatggccagc ccgaaaacaa ctacaagacc acaccccctg tgctggacag cgacggcagc     1200

ttctttctgt atagcaaact gacagtggat aagagcagat ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagcctg     1320

tcccccggaa aatga                                                      1335


<210>  119
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A4-IgG1 D265A chimeric antibody heavy chain full length protein 
       sequence

<400>  119

Gln Ile His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  120
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A4-IgG4 F234A L235A chimeric antibody heavy chain full length 
       DNA sequence

<400>  120
cagatccact tggtgcagtc tggacctgaa ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactttggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataagtggct acactaggga gccaacatat      180

gctgctgact tcaagggacg atttgccatc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acgacctcaa aaatgaagac atggctacat atttctgtgc aagagacgtt      300

tttgactact ggggccaagg caccactctc acagtctcga gcgcctccac caagggaccc      360

agcgtgtttc ccctggcccc ctgttccaga tccacctccg aaagcacagc cgctctcggc      420

tgcctggtca aggattactt ccctgagccc gtgacagtct cctggaatag cggcgctctg      480

acctccggcg tgcatacctt ccctgctgtg ctgcaatcct ccggactgta cagcctgagc      540

agcgtggtca ccgtgccttc ctccagcctg ggaaccaaaa cctacacatg caacgtggac      600

cacaagccca gcaacaccaa agtggacaag agggtggagt ccaagtacgg acccccttgt      660

cctccctgcc ctgctcctga agccgctgga ggacctagcg tgttcctgtt tccccccaag      720

cccaaggaca ccctcatgat ctccaggacc cccgaggtga cctgtgtcgt ggtggacgtg      780

agccaagagg accccgaggt gcagttcaac tggtacgtgg atggcgtcga ggtccataac      840

gccaagacca agcctaggga ggagcagttc aacagcacct acagagtggt gagcgtcctg      900

accgtgctcc accaagactg gctgaacggc aaggaataca agtgcaaggt ctccaacaag      960

ggactccctt cctccatcga gaagaccatc agcaaggcca agggccagcc cagagaaccc     1020

caagtctaca cactgccccc cagccaagag gaaatgacca agaaccaggt gagcctgacc     1080

tgcctggtga aaggcttcta ccccagcgac attgctgtcg aatgggagag caacggccaa     1140

cccgagaaca actacaagac caccccccct gtgctcgaca gcgacggctc cttcttcctc     1200

tacagcaggc tgacagtgga caagtccagg tggcaagagg gcaatgtctt cagctgtagc     1260

gtcatgcacg aggccctcca caaccactac acccagaaga gcctgtccct ctccctgggc     1320

tga                                                                   1323


<210>  121
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A4-IgG4 F234A L235A chimeric antibody heavy chain full length 
       protein sequence

<400>  121

Gln Ile His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asp Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440 


<210>  122
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A4 chimeric antibody light chain full length DNA sequence

<400>  122
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atttcctgca gagccagtga aagtgttgat aattatggct atagttttat gaactggttc      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacaa acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat ttctgtcagc aaagtaatgc ggatccgacg      300

ttcggtggag gcaccaacct ggaaatcaaa cgtacggtgg ccgcaccaag cgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agctttaaca gaggcgagtg ctga            654


<210>  123
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A4 chimeric antibody light chain full length protein sequence

<400>  123

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Tyr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asn Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Phe Cys Gln Gln Ser Asn 
                85                  90                  95      


Ala Asp Pro Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  124
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13F1-IgG1 D265A chimeric antibody heavy chain full length DNA 
       sequence

<400>  124
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa accaactgga gtggatggcc tacattagtt acagtggtta cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagatctctt      300

gactatgatt acggaactat ggactactgg ggtcaaggaa cctcagtcac cgtctcgagc      360

gcctccacta agggcccatc cgtgttccct ctggcaccct ccagcaagag cacaagcgga      420

ggcaccgccg cactgggctg cctcgtgaag gactacttcc cagaacccgt gaccgtcagc      480

tggaatagcg gcgctctgac cagcggagtc cacactttcc ccgcagtgct gcagtccagc      540

ggcctgtaca gcctgagcag cgtggtcact gtgccaagca gcagcctggg cactcagacc      600

tacatctgca acgtcaacca caagcccagc aacacaaagg tggacaagaa ggtcgagccc      660

aagtcctgcg ataagaccca cacctgccct ccatgtcccg cccccgagct gctgggagga      720

cccagcgtct tcctgtttcc ccccaagcca aaggacaccc tgatgatcag caggaccccc      780

gaagtgacct gcgtcgtggt ggccgtgagc cacgaagatc ccgaggtgaa gttcaactgg      840

tacgtggacg gcgtggaagt gcacaacgcc aagacaaaac ccagggagga gcagtatgcc      900

agcacctaca gggtcgtgag cgtcctgacc gtgctgcacc aagactggct gaacggcaag      960

gagtataagt gcaaggtgag caacaaggca ctgcccgccc ccatcgagaa gaccatttcc     1020

aaggccaagg ggcaacctag ggagccacag gtctacactc tgccccctag cagggacgag     1080

ctgaccaaga accaggtctc cctgacttgc ctggtgaagg ggttttatcc cagcgacatc     1140

gccgtcgagt gggagagcaa tggccagccc gaaaacaact acaagaccac accccctgtg     1200

ctggacagcg acggcagctt ctttctgtat agcaaactga cagtggataa gagcagatgg     1260

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc ccccggaaaa tga                                  1353


<210>  125
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13F1-IgG1 D265A chimeric antibody heavy chain full length protein
       sequence

<400>  125

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gln Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  126
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13F1-IgG4 F234A L235A chimeric antibody heavy chain full length 
       DNA sequence

<400>  126
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa accaactgga gtggatggcc tacattagtt acagtggtta cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagatctctt      300

gactatgatt acggaactat ggactactgg ggtcaaggaa cctcagtcac cgtctcgagc      360

gcctccacca agggacccag cgtgtttccc ctggccccct gttccagatc cacctccgaa      420

agcacagccg ctctcggctg cctggtcaag gattacttcc ctgagcccgt gacagtctcc      480

tggaatagcg gcgctctgac ctccggcgtg cataccttcc ctgctgtgct gcaatcctcc      540

ggactgtaca gcctgagcag cgtggtcacc gtgccttcct ccagcctggg aaccaaaacc      600

tacacatgca acgtggacca caagcccagc aacaccaaag tggacaagag ggtggagtcc      660

aagtacggac ccccttgtcc tccctgccct gctcctgaag ccgctggagg acctagcgtg      720

ttcctgtttc cccccaagcc caaggacacc ctcatgatct ccaggacccc cgaggtgacc      780

tgtgtcgtgg tggacgtgag ccaagaggac cccgaggtgc agttcaactg gtacgtggat      840

ggcgtcgagg tccataacgc caagaccaag cctagggagg agcagttcaa cagcacctac      900

agagtggtga gcgtcctgac cgtgctccac caagactggc tgaacggcaa ggaatacaag      960

tgcaaggtct ccaacaaggg actcccttcc tccatcgaga agaccatcag caaggccaag     1020

ggccagccca gagaacccca agtctacaca ctgcccccca gccaagagga aatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaaa ggcttctacc ccagcgacat tgctgtcgaa     1140

tgggagagca acggccaacc cgagaacaac tacaagacca ccccccctgt gctcgacagc     1200

gacggctcct tcttcctcta cagcaggctg acagtggaca agtccaggtg gcaagagggc     1260

aatgtcttca gctgtagcgt catgcacgag gccctccaca accactacac ccagaagagc     1320

ctgtccctct ccctgggctg a                                               1341


<210>  127
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13F1-IgG4 F234A L235A chimeric antibody heavy chain full length 
       protein sequence

<400>  127

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gln Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  128
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13F1 chimeric antibody light chain full length DNA sequence

<400>  128
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacctgca gggccaactc aagtgtaagt tccatgcact ggtaccagca gaagccagga      120

tcctcccccg aaccctggat ttatgccatt tccaacctgg cttttggagt ccctactcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttatttctg ccagcagtgg agtagtagac cacccacgtt cggagggggg      300

accaagctgg aaataaaacg tacggtggcc gcaccaagcg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag ctttaacaga ggcgagtgct ga                         642


<210>  129
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13F1 chimeric antibody light chain full length protein sequence

<400>  129

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Asn Ser Ser Val Ser Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Glu Pro Trp Ile Tyr 
        35                  40                  45              


Ala Ile Ser Asn Leu Ala Phe Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Ser Ser Arg Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  130
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4 antibody heavy chain variable region DNA sequence

<400>  130
cagatccagc tggtgcagag cgggagcgaa ctgaaaaaac ctggggcaag cgtgaaagtc       60

tcatgtaaag caagcggcta cacatttacc aacttcggca tgaattgggt caggcaggca      120

ccaggacagg gactgaagtg gatggggtgg atctccggat acactcggga gcctacctat      180

gccgctgact tcaaagggag atttgtgatc agtctggata catcagtcag cactgcttac      240

ctgcagatta gctccctgaa ggcagaagac acagccgtgt actattgcgc acgggacgtc      300

tttgattatt ggggacaggg caccctggtg acagtctcga gc                         342


<210>  131
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4 antibody heavy chain variable region protein 
       sequence

<400>  131

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Ile Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  132
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4 antibody light chain variable region DNA sequence

<400>  132
gacatcgtcc tgacacagtc tcccgcatcc ctggccgtct ctcccggaca gcgagcaaca       60

atcacctgcc gagcatctga aagcgtggat aactacgggt atagcttcat gaattggttt      120

cagcagaagc ccggacagcc ccctaaactg ctgatctaca gggcaagtaa cctggagtca      180

ggagtgccag cacgattcag cggatccggg tctagaacag actttaccct gacaattaac      240

cccgtcgaag ccaacgatac cgctaattac tattgccagc agtctaatgc tgaccctact      300

ttcggacagg gcaccaagct ggagatcaaa                                       330


<210>  133
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4 antibody light chain variable region protein 
       sequence

<400>  133

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Tyr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Ala Asp Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  134
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4-IgG1 D265A antibody heavy chain full length DNA 
       sequence

<400>  134
cagatccagc tggtgcagag cgggagcgaa ctgaaaaaac ctggggcaag cgtgaaagtc       60

tcatgtaaag caagcggcta cacatttacc aacttcggca tgaattgggt caggcaggca      120

ccaggacagg gactgaagtg gatggggtgg atctccggat acactcggga gcctacctat      180

gccgctgact tcaaagggag atttgtgatc agtctggata catcagtcag cactgcttac      240

ctgcagatta gctccctgaa ggcagaagac acagccgtgt actattgcgc acgggacgtc      300

tttgattatt ggggacaggg caccctggtg acagtctcga gcgcctccac taagggccca      360

tccgtgttcc ctctggcacc ctccagcaag agcacaagcg gaggcaccgc cgcactgggc      420

tgcctcgtga aggactactt cccagaaccc gtgaccgtca gctggaatag cggcgctctg      480

accagcggag tccacacttt ccccgcagtg ctgcagtcca gcggcctgta cagcctgagc      540

agcgtggtca ctgtgccaag cagcagcctg ggcactcaga cctacatctg caacgtcaac      600

cacaagccca gcaacacaaa ggtggacaag aaggtcgagc ccaagtcctg cgataagacc      660

cacacctgcc ctccatgtcc cgcccccgag ctgctgggag gacccagcgt cttcctgttt      720

ccccccaagc caaaggacac cctgatgatc agcaggaccc ccgaagtgac ctgcgtcgtg      780

gtggccgtga gccacgaaga tcccgaggtg aagttcaact ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagacaaa acccagggag gagcagtata acagcaccta cagggtcgtg      900

agcgtcctga ccgtgctgca ccaagactgg ctgaacggca aggagtataa gtgcaaggtg      960

agcaacaagg cactgcccgc ccccatcgag aagaccattt ccaaggccaa ggggcaacct     1020

agggagccac aggtctacac tctgccccct agcagggacg agctgaccaa gaaccaggtc     1080

tccctgactt gcctggtgaa ggggttttat cccagcgaca tcgccgtcga gtgggagagc     1140

aatggccagc ccgaaaacaa ctacaagacc acaccccctg tgctggacag cgacggcagc     1200

ttctttctgt atagcaaact gacagtggat aagagcagat ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aatcactaca cccagaagtc cctgagcctg     1320

tcccccggaa aatga                                                      1335


<210>  135
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4-IgG1 D265A antibody heavy chain full length protein
       sequence

<400>  135

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Ile Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  136
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4-IgG4 F234A L235A antibody heavy chain full length 
       DNA sequence

<400>  136
cagatccagc tggtgcagag cgggagcgaa ctgaaaaaac ctggggcaag cgtgaaagtc       60

tcatgtaaag caagcggcta cacatttacc aacttcggca tgaattgggt caggcaggca      120

ccaggacagg gactgaagtg gatggggtgg atctccggat acactcggga gcctacctat      180

gccgctgact tcaaagggag atttgtgatc agtctggata catcagtcag cactgcttac      240

ctgcagatta gctccctgaa ggcagaagac acagccgtgt actattgcgc acgggacgtc      300

tttgattatt ggggacaggg caccctggtg acagtctcga gcgcctccac caagggaccc      360

agcgtgtttc ccctggcccc ctgttccaga tccacctccg aaagcacagc cgctctcggc      420

tgcctggtca aggattactt ccctgagccc gtgacagtct cctggaatag cggcgctctg      480

acctccggcg tgcatacctt ccctgctgtg ctgcaatcct ccggactgta cagcctgagc      540

agcgtggtca ccgtgccttc ctccagcctg ggaaccaaaa cctacacatg caacgtggac      600

cacaagccca gcaacaccaa agtggacaag agggtggagt ccaagtacgg acccccttgt      660

cctccctgcc ctgctcctga agccgctgga ggacctagcg tgttcctgtt tccccccaag      720

cccaaggaca ccctcatgat ctccaggacc cccgaggtga cctgtgtcgt ggtggacgtg      780

agccaagagg accccgaggt gcagttcaac tggtacgtgg atggcgtcga ggtccataac      840

gccaagacca agcctaggga ggagcagttc aacagcacct acagagtggt gagcgtcctg      900

accgtgctcc accaagactg gctgaacggc aaggaataca agtgcaaggt ctccaacaag      960

ggactccctt cctccatcga gaagaccatc agcaaggcca agggccagcc cagagaaccc     1020

caagtctaca cactgccccc cagccaagag gaaatgacca agaaccaggt gagcctgacc     1080

tgcctggtga aaggcttcta ccccagcgac attgctgtcg aatgggagag caacggccaa     1140

cccgagaaca actacaagac caccccccct gtgctcgaca gcgacggctc cttcttcctc     1200

tacagcaggc tgacagtgga caagtccagg tggcaagagg gcaatgtctt cagctgtagc     1260

gtcatgcacg aggccctcca caaccactac acccagaaga gcctgtccct ctccctgggc     1320

tga                                                                   1323


<210>  137
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4-IgG4 F234A L235A antibody heavy chain full length 
       protein sequence

<400>  137

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Thr Arg Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Ile Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440 


<210>  138
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4 antibody light chain full length DNA sequence

<400>  138
gacatcgtcc tgacacagtc tcccgcatcc ctggccgtct ctcccggaca gcgagcaaca       60

atcacctgcc gagcatctga aagcgtggat aactacgggt atagcttcat gaattggttt      120

cagcagaagc ccggacagcc ccctaaactg ctgatctaca gggcaagtaa cctggagtca      180

ggagtgccag cacgattcag cggatccggg tctagaacag actttaccct gacaattaac      240

cccgtcgaag ccaacgatac cgctaattac tattgccagc agtctaatgc tgaccctact      300

ttcggacagg gcaccaagct ggagatcaaa cgtacggtgg ccgcaccaag cgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agctttaaca gaggcgagtg ctga            654


<210>  139
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 7A4 antibody light chain full length protein sequence

<400>  139

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Tyr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Ala Asp Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  140
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1 antibody heavy chain variable region DNA sequence

<400>  140
caggtgcagc tgcaggagag cggacccgga ctggtgaagc ctagccagac actgagcctg       60

acttgtactg tgagcggata ttccattagc tccgactacg cttggaactg gatcaggcag      120

ccacctggca agggactgga gtggatggcc tacatttcct attctgggta caccagctat      180

aaccccagtc tgaaatcacg gatcacaatt agcagagaca cttccaagaa tcagttctct      240

ctgaaactgt ctagtgtgac tgccgctgat accgcagtct actattgcgc ccggtccctg      300

gactacgatt atggcacaat ggattattgg ggacagggca ccctggtgac agtctcgagc      360


<210>  141
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1 antibody heavy chain variable region protein 
       sequence

<400>  141

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  142
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1 antibody light chain variable region DNA sequence

<400>  142
gaaatcgtcc tgacccagag tcccgccacc ctgtcactga gccccggaga aagagccaca       60

ctgagttgta gagcaaatag cagcgtgagc tccatgcact ggtaccagca gaagcctgga      120

cagtccccag agccctggat ctatgccatt agcaacctgg ctttcggcgt gccagcaagg      180

ttttccggct ctgggagtgg aacagactac accctgacaa tctctagtct ggagcccgaa      240

gatttcgccg tctactattg ccagcagtgg tcaagccggc cccctacttt tggccagggg      300

accaagctgg agatcaag                                                    318


<210>  143
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1 antibody light chain variable region protein 
       sequence

<400>  143

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Asn Ser Ser Val Ser Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Pro Trp Ile Tyr 
        35                  40                  45              


Ala Ile Ser Asn Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Arg Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  144
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1-IgG1 D265A antibody heavy chain full length DNA 
       sequence

<400>  144
caggtgcagc tgcaggagag cggacccgga ctggtgaagc ctagccagac actgagcctg       60

acttgtactg tgagcggata ttccattagc tccgactacg cttggaactg gatcaggcag      120

ccacctggca agggactgga gtggatggcc tacatttcct attctgggta caccagctat      180

aaccccagtc tgaaatcacg gatcacaatt agcagagaca cttccaagaa tcagttctct      240

ctgaaactgt ctagtgtgac tgccgctgat accgcagtct actattgcgc ccggtccctg      300

gactacgatt atggcacaat ggattattgg ggacagggca ccctggtgac agtctcgagc      360

gcctccacta agggcccatc cgtgttccct ctggcaccct ccagcaagag cacaagcgga      420

ggcaccgccg cactgggctg cctcgtgaag gactacttcc cagaacccgt gaccgtcagc      480

tggaatagcg gcgctctgac cagcggagtc cacactttcc ccgcagtgct gcagtccagc      540

ggcctgtaca gcctgagcag cgtggtcact gtgccaagca gcagcctggg cactcagacc      600

tacatctgca acgtcaacca caagcccagc aacacaaagg tggacaagaa ggtcgagccc      660

aagtcctgcg ataagaccca cacctgccct ccatgtcccg cccccgagct gctgggagga      720

cccagcgtct tcctgtttcc ccccaagcca aaggacaccc tgatgatcag caggaccccc      780

gaagtgacct gcgtcgtggt ggccgtgagc cacgaagatc ccgaggtgaa gttcaactgg      840

tacgtggacg gcgtggaagt gcacaacgcc aagacaaaac ccagggagga gcagtataac      900

agcacctaca gggtcgtgag cgtcctgacc gtgctgcacc aagactggct gaacggcaag      960

gagtataagt gcaaggtgag caacaaggca ctgcccgccc ccatcgagaa gaccatttcc     1020

aaggccaagg ggcaacctag ggagccacag gtctacactc tgccccctag cagggacgag     1080

ctgaccaaga accaggtctc cctgacttgc ctggtgaagg ggttttatcc cagcgacatc     1140

gccgtcgagt gggagagcaa tggccagccc gaaaacaact acaagaccac accccctgtg     1200

ctggacagcg acggcagctt ctttctgtat agcaaactga cagtggataa gagcagatgg     1260

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgagcctgtc ccccggaaaa tga                                  1353


<210>  145
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1-IgG1 D265A antibody heavy chain full length 
       protein sequence

<400>  145

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  146
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1-IgG4 F234A L235A antibody heavy chain full length 
       DNA sequence

<400>  146
caggtgcagc tgcaggagag cggacccgga ctggtgaagc ctagccagac actgagcctg       60

acttgtactg tgagcggata ttccattagc tccgactacg cttggaactg gatcaggcag      120

ccacctggca agggactgga gtggatggcc tacatttcct attctgggta caccagctat      180

aaccccagtc tgaaatcacg gatcacaatt agcagagaca cttccaagaa tcagttctct      240

ctgaaactgt ctagtgtgac tgccgctgat accgcagtct actattgcgc ccggtccctg      300

gactacgatt atggcacaat ggattattgg ggacagggca ccctggtgac agtctcgagc      360

gcctccacca agggacccag cgtgtttccc ctggccccct gttccagatc cacctccgaa      420

agcacagccg ctctcggctg cctggtcaag gattacttcc ctgagcccgt gacagtctcc      480

tggaatagcg gcgctctgac ctccggcgtg cataccttcc ctgctgtgct gcaatcctcc      540

ggactgtaca gcctgagcag cgtggtcacc gtgccttcct ccagcctggg aaccaaaacc      600

tacacatgca acgtggacca caagcccagc aacaccaaag tggacaagag ggtggagtcc      660

aagtacggac ccccttgtcc tccctgccct gctcctgaag ccgctggagg acctagcgtg      720

ttcctgtttc cccccaagcc caaggacacc ctcatgatct ccaggacccc cgaggtgacc      780

tgtgtcgtgg tggacgtgag ccaagaggac cccgaggtgc agttcaactg gtacgtggat      840

ggcgtcgagg tccataacgc caagaccaag cctagggagg agcagttcaa cagcacctac      900

agagtggtga gcgtcctgac cgtgctccac caagactggc tgaacggcaa ggaatacaag      960

tgcaaggtct ccaacaaggg actcccttcc tccatcgaga agaccatcag caaggccaag     1020

ggccagccca gagaacccca agtctacaca ctgcccccca gccaagagga aatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaaa ggcttctacc ccagcgacat tgctgtcgaa     1140

tgggagagca acggccaacc cgagaacaac tacaagacca ccccccctgt gctcgacagc     1200

gacggctcct tcttcctcta cagcaggctg acagtggaca agtccaggtg gcaagagggc     1260

aatgtcttca gctgtagcgt catgcacgag gccctccaca accactacac ccagaagagc     1320

ctgtccctct ccctgggctg a                                               1341


<210>  147
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1-IgG4 F234A L235A antibody heavy chain full length 
       protein sequence

<400>  147

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Ser Tyr Ser Gly Tyr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Tyr Gly Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     


<210>  148
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1 antibody light chain full length DNA sequence

<400>  148
gaaatcgtcc tgacccagag tcccgccacc ctgtcactga gccccggaga aagagccaca       60

ctgagttgta gagcaaatag cagcgtgagc tccatgcact ggtaccagca gaagcctgga      120

cagtccccag agccctggat ctatgccatt agcaacctgg ctttcggcgt gccagcaagg      180

ttttccggct ctgggagtgg aacagactac accctgacaa tctctagtct ggagcccgaa      240

gatttcgccg tctactattg ccagcagtgg tcaagccggc cccctacttt tggccagggg      300

accaagctgg agatcaagcg tacggtggcc gcaccaagcg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag ctttaacaga ggcgagtgct ga                         642


<210>  149
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 13F1 antibody light chain full length protein sequence

<400>  149

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Asn Ser Ser Val Ser Ser Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Pro Trp Ile Tyr 
        35                  40                  45              


Ala Ile Ser Asn Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Arg Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  150
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  150

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  151
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  151

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  152
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A4D Humanized Light chain variable

<400>  152

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Tyr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Ala Asp Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  153
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A4D Humanized Full light chain

<400>  153

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Tyr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Ala Asp Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


