                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> SORTASE MOLECULES AND USES THEREOF

<130> N2067-7056WO

<140>
<141>

<150> 62/027,137
<151> 2014-07-21

<160> 49    

<170> PatentIn version 3.5

<210> 1
<211> 206
<212> PRT
<213> Staphylococcus aureus

<400> 1
Met Lys Lys Trp Thr Asn Arg Leu Met Thr Ile Ala Gly Val Val Leu 
1               5                   10                  15      


Ile Leu Val Ala Ala Tyr Leu Phe Ala Lys Pro His Ile Asp Asn Tyr 
            20                  25                  30          


Leu His Asp Lys Asp Lys Asp Glu Lys Ile Glu Gln Tyr Asp Lys Asn 
        35                  40                  45              


Val Lys Glu Gln Ala Ser Lys Asp Asn Lys Gln Gln Ala Lys Pro Gln 
    50                  55                  60                  


Ile Pro Lys Asp Lys Ser Lys Val Ala Gly Tyr Ile Glu Ile Pro Asp 
65                  70                  75                  80  


Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly Pro Ala Thr Pro Glu Gln 
                85                  90                  95      


Leu Asn Arg Gly Val Ser Phe Ala Glu Glu Asn Glu Ser Leu Asp Asp 
            100                 105                 110         


Gln Asn Ile Ser Ile Ala Gly His Thr Phe Ile Asp Arg Pro Asn Tyr 
        115                 120                 125             


Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys Gly Ser Met Val Tyr Phe 
    130                 135                 140                 


Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys Met Thr Ser Ile Arg Asp 
145                 150                 155                 160 


Val Lys Pro Thr Asp Val Glu Val Leu Asp Glu Gln Lys Gly Lys Asp 
                165                 170                 175     


Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp Tyr Asn Glu Lys Thr Gly 
            180                 185                 190         


Val Trp Glu Lys Arg Lys Ile Phe Val Ala Thr Glu Val Lys 
        195                 200                 205     


<210> 2
<211> 59
<212> PRT
<213> Staphylococcus aureus

<400> 2
Met Lys Lys Trp Thr Asn Arg Leu Met Thr Ile Ala Gly Val Val Leu 
1               5                   10                  15      


Ile Leu Val Ala Ala Tyr Leu Phe Ala Lys Pro His Ile Asp Asn Tyr 
            20                  25                  30          


Leu His Asp Lys Asp Lys Asp Glu Lys Ile Glu Gln Tyr Asp Lys Asn 
        35                  40                  45              


Val Lys Glu Gln Ala Ser Lys Asp Asn Lys Gln 
    50                  55                  


<210> 3
<211> 147
<212> PRT
<213> Staphylococcus aureus

<400> 3
Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val Ala Gly Tyr 
1               5                   10                  15      


Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly Pro 
            20                  25                  30          


Ala Thr Pro Glu Gln Leu Asn Arg Gly Val Ser Phe Ala Glu Glu Asn 
        35                  40                  45              


Glu Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His Thr Phe Ile 
    50                  55                  60                  


Asp Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys Gly 
65                  70                  75                  80  


Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys Met 
                85                  90                  95      


Thr Ser Ile Arg Asp Val Lys Pro Thr Asp Val Glu Val Leu Asp Glu 
            100                 105                 110         


Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp Tyr 
        115                 120                 125             


Asn Glu Lys Thr Gly Val Trp Glu Lys Arg Lys Ile Phe Val Ala Thr 
    130                 135                 140                 


Glu Val Lys 
145         


<210> 4
<211> 621
<212> DNA
<213> Staphylococcus aureus

<400> 4
atgaaaaaat ggacaaatcg attaatgaca atcgctggtg tagtacttat cctagtggca       60

gcatatttgt ttgctaaacc acatatcgat aattatcttc acgataaaga taaagatgaa      120

aagattgaac aatatgataa aaatgtaaaa gaacaggcga gtaaagacaa taagcagcaa      180

gctaaacctc aaattccgaa agataaatca aaagtggcag gctatattga aattccagat      240

gctgatatta aagaaccagt atatccagga ccagcaacac ctgaacaatt aaatagaggt      300

gtaagctttg cagaagaaaa tgaatcacta gatgatcaaa atatttcaat tgcaggacac      360

actttcattg accgtccgaa ctatcaattt acaaatctta aagcagccaa aaaaggtagt      420

atggtgtact ttaaagttgg taatgaaaca cgtaagtata aaatgacaag tataagagat      480

gttaagccaa cagatgtaga agttctagat gaacaaaaag gtaaagataa acaattaaca      540

ttaattactt gtgatgatta caatgaaaag acaggcgttt gggaaaaacg taaaatcttt      600

gtagctacag aagtcaaata a                                                621


<210> 5
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val Ala Gly 
1               5                   10                  15      


Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly 
            20                  25                  30          


Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe Ala Lys Glu 
        35                  40                  45              


Asn Gln Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His Thr Phe 
    50                  55                  60                  


Ile Asp Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys 
65                  70                  75                  80  


Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys 
                85                  90                  95      


Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Glu Val Leu Asp 
            100                 105                 110         


Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp 
        115                 120                 125             


Tyr Asn Glu Glu Thr Gly Val Trp Glu Thr Arg Lys Ile Phe Val Ala 
    130                 135                 140                 


Thr Glu Val Lys Leu Glu His His His His His His 
145                 150                 155     


<210> 6
<211> 284
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val 
                165                 170                 175     


Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val 
            180                 185                 190         


Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser Arg 
        195                 200                 205             


Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu 
    210                 215                 220                 


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His 
225                 230                 235                 240 


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Leu Pro Glu Thr Gly Gly Leu Asp Val Leu 
            260                 265                 270         


Phe Glu Gly Pro His His His His His His His His 
        275                 280                 


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Gly Gly Gly Lys 
1               


<210> 8
<211> 817
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
gctagccacc atggaaaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg       60

cagcaccggc gataagaccc acacctgtcc tccctgtcct gcccctgaag ctgctggcgg      120

ccctagcgtg ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc      180

cgaagtgacc tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg      240

gtacgtggac ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa      300

cagcacctac cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa      360

agagtacaag tgcaaggtgt ccaacaaggc cctgccagcc cccatcgaga aaaccatcag      420

caaggccaag ggccagcccc gcgaacccca ggtgtacaca ctgcccccta gccgggaaga      480

gatgaccaag aaccaggtgt ccctgacctg tctcgtgaag ggcttctacc cctccgatat      540

cgccgtggaa tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt      600

gctggacagc gacggctcat tcttcctgta cagcaagctg acagtggaca agagccggtg      660

gcagcagggc aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac      720

ccagaagtcc ctgagcctga gccctggaaa aggcggcgga ggctctctgc ctgaaacagg      780

cggactggaa gtgctgttcc agggccccta agaattc                               817


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Gly Gly Gly Gly Ser 
1               5   


<210> 10
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Leu Pro Glu Thr Gly Gly Leu Glu Val Leu Phe Gln Gly Pro 
1               5                   10                  


<210> 11
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Gly Leu Glu Val Leu Phe Gln Gly Pro 
1               5                   10  


<210> 12
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Leu Pro Glu Thr 
                245                 250                 255     


Gly Gly Leu Glu Val Leu Phe Gln Gly Pro 
            260                 265     


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> D-Nle

<400> 13
Gly Gly Gly Gly Gly Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
1               5                   10                  15      


<210> 14
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (272)..(272)
<223> D-Nle

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Leu Pro Glu Thr 
                245                 250                 255     


Gly Gly Gly Gly Gly Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
            260                 265                 270         


<210> 15
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Nle

<400> 15
Gly Gly Gly Gly Gly Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa 
1               5                   10                  15      


Cys Phe 
        


<210> 16
<211> 156
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Met Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val Ala Gly 
1               5                   10                  15      


Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr Pro Gly 
            20                  25                  30          


Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe Ala Lys Glu 
        35                  40                  45              


Asn Gln Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His Thr Phe 
    50                  55                  60                  


Ile Asp Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala Lys Lys 
65                  70                  75                  80  


Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys Tyr Lys 
                85                  90                  95      


Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Glu Val Leu Asp 
            100                 105                 110         


Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp Asp 
        115                 120                 125             


Tyr Asn Glu Glu Thr Gly Val Trp Glu Thr Arg Lys Ile Phe Val Ala 
    130                 135                 140                 


Thr Glu Val Lys Leu Glu His His His His His His 
145                 150                 155     


<210> 17
<211> 274
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (272)..(272)
<223> Nle

<400> 17
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Leu Pro Glu Thr 
                245                 250                 255     


Gly Gly Gly Gly Gly Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa 
            260                 265                 270         


Cys Phe 
        


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Leu Pro Glu Thr Gly Gly Gly Gly Gly 
1               5                   


<210> 19
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Nle

<400> 19
Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa Cys Phe 
1               5                   10              


<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro 
            


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> D-Nle

<400> 21
Gly Gly Gly Gly Gly Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
1               5                   10                  15      


<210> 22
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (25)..(25)
<223> D-Nle

<400> 22
Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly Gly Gly Gly Gln Arg 
1               5                   10                  15      


Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
            20                  25  


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> D-Nle

<400> 23
Gly Gly Gly Gly Gly Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
1               5                   10                  15      


<210> 24
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> D-Nle

<400> 24
Gly Gly Gly Gly Gly Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
1               5                   10                  15      


<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> D-Nle

<400> 25
Gly Gly Gly Gly Gly Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
1               5                   10                  15      


<210> 26
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro 
            


<210> 27
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Nle

<400> 27
Gly Gly Gly Gly Gly Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa 
1               5                   10                  15      


Cys Phe 
        


<210> 28
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (25)..(25)
<223> Nle

<400> 28
Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly Gly Gly Gly Gln Arg 
1               5                   10                  15      


Pro Arg Leu Cys His Lys Gly Pro Xaa Cys Phe 
            20                  25          


<210> 29
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Nle

<400> 29
Gly Gly Gly Gly Gly Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa 
1               5                   10                  15      


Cys Phe 
        


<210> 30
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Nle

<400> 30
Gly Gly Gly Gly Gly Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa 
1               5                   10                  15      


Cys Phe 
        


<210> 31
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Nle

<400> 31
Gly Gly Gly Gly Gly Gln Arg Pro Arg Leu Cys His Lys Gly Pro Xaa 
1               5                   10                  15      


Cys Phe 
        


<210> 32
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 32
His His His His His His 
1               5       


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      8xHis tag"

<400> 33
His His His His His His His His 
1               5               


<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Gly Gly Gly 
1               


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Gly Gly Gly Gly 
1               5   


<210> 36
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ala Ala Ala Ala 
1               


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Ala Ala Ala Ala Ala 
1               5   


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 38
Leu Pro Xaa Thr Gly 
1               5   


<210> 39
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Leu Pro Glu Thr Gly 
1               5   


<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(6)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(6)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 40
Gly Gly Gly Gly Gly Gly 
1               5       


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(6)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(6)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 41
Ala Ala Ala Ala Ala Ala 
1               5       


<210> 42
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 42
Leu Pro Xaa Thr Gly Gly 
1               5       


<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Gly Gly Gly Ser 
1               


<210> 44
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 45
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Leu Pro Glu Thr Gly Gly 
1               5       


<210> 47
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Leu Pro Glu Thr 
1               5                   10                  15      


Gly Gly Gly Gly Gly 
            20      


<210> 48
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (11)..(11)
<223> D-Nle

<400> 48
Gln Arg Pro Cys Leu Ser Cys Lys Gly Pro Xaa 
1               5                   10      


<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Leu Pro Glu Thr Gly Gly Gly Lys 
1               5               


