                         SEQUENCE LISTING

<110>  THERAVECTYS
       Institut Curie
       Centre National de la Recherche Scientifique
       Institut National de la Sant et de la Recherche Mdicale
       Universit Pierre et Marie Curie
 
<120>  LENTIVIRAL VECTORS FOR REGULATED EXPRESSION OF A CHIMERIC ANTIGEN
        RECEPTOR MOLECULE

<130>  THERA14.16-PCT

<150>  62/028,889
<151>  2014-07-25

<150>  62/155,811
<151>  2015-05-01

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hook-binding domain

<400>  1

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210>  2
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hook-binding domain

<400>  2
atggacgaga aaaccaccgg ctggcgggga ggccacgtgg tggaaggact ggccggcgag       60

ctggaacagc tgcgggccag actggaacac cacccccagg gccagagaga gccc            114


<210>  3
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu Pro 
1               5                   10                  15      


Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys Tyr 
            20                  25                  30          


Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu 
        35                  40                  45              


Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    50                  55                  60                  


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
65                  70                  75                  80  


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                85                  90                  95      


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  4
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  5
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  6
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  7
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  8
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  9
<211>  220
<212>  DNA
<213>  Homo sapiens

<400>  9
attggggagt cccagccttg gggattcccc aactccgcag tttcttttct ccctctccca       60

acctatgtag ggtccttctt cctggatact cacgacgcgg acccagttct cactcccatt      120

gggtgtcggg tttccagaga agccaatcag tgtcgtcgcg gtcgcggttc taaagtccgc      180

acgcacccac cgggactcag attctcccca gacgccgagg                            220


<210>  10
<211>  197
<212>  DNA
<213>  Homo sapiens

<400>  10
ggggaggcgc agcgttgggg attccccact cccctgagtt tcacttcttc tcccaacttg       60

tgtcgggtcc ttcttccagg atactcgtga cgcgtcccca cttcccactc ccattgggta      120

ttggatatct agagaagcca atcagcgtcg ccgcggtccc agttctaaag tccccacgca      180

cccacccgga ctcagag                                                     197


<210>  11
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  11
cactggggag gcgccgcgtt gaggattctc cactcccctc agtttcactt cttctcccaa       60

cctgcgtcgg gtccttcttc ctgaatactc atgacgcgtc cccaattccc actcccattg      120

ggtgtcgggt tctagagaag ccaatcagcg tctccgcagt cccggtctaa agtccccagt      180

cacccacccg gactcagatt ctccccagac gccgag                                216


<210>  12
<211>  205
<212>  DNA
<213>  Homo sapiens

<400>  12
taagaactgc tgattgctgg gaaactctgc agtttcccgt tcctctcgta acctggtcat       60

gtgtccttct tcctggatac tcatgacgca gactcagttc tcattcccaa tgggtgtcgg      120

gtttctagag aagccaatca gcgtcgccac gactcccgac tataaagtcc ccatccggac      180

tcaagaagtt ctcaggactc agagg                                            205


<210>  13
<211>  252
<212>  DNA
<213>  Homo sapiens

<400>  13
aggccccgag gcggtgtctg gggttggaag gctcagtatt gagaattccc catctcccca       60

gagtttctct ttctctccca acccgtgtca ggtccttcat cctggatact cataacgcgg      120

ccccatttct cactcccatt gggcgtcgcg tttctagaga agccaatcag tgtcgccgca      180

gttcccaggt tctaaagtcc cacgcacccc gcgggactca tatttttccc agacgcggag      240

gttggggtca tg                                                          252


<210>  14
<211>  192
<212>  DNA
<213>  Homo sapiens

<400>  14
aacatcacga gactctaaga aaaggaaact gaaaacggga aagtccctct ctctaacctg       60

gcactgcgtc gctggcttgg agacaggtga cggtccctgc gggccttgtc ctgattggct      120

gggcacgcgt ttaatataag tggaggcgtc gcgctggcgg gcattcctga agctgacagc      180

attcgggccg ag                                                          192


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  15
cttactagtt ggaagggcta attcactccc aac                                    33


<210>  16
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  16
cattctagaa ctgctagaga ttttccacac tg                                     32


<210>  17
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  17
taccccgggc catggcctcc aaaaaagcct cctcactact tc                          42


<210>  18
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  18
actcccgggt aatttttttt atttatgcag aggccgaggc cgcc                        44


<210>  19
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  19
tacacgcgtg gagttccgcg ttacataact tacgg                                  35


<210>  20
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  20
cgtggatccg atcgcggtgt cttctatgga ggtcaaaac                              39


<210>  21
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  21
gccggcgcgc cgagaaaccc tgcagggaat tccc                                   34


<210>  22
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  22
cgtggatccg atcgctcggc ccgaatgctg tcagcttcag g                           41


<210>  23
<211>  517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter

<400>  23
gagaaaccct gcagggaatt ccccagctgt agttataaac agaagttctc cttctgctag       60

gtagcattca aagatcttaa tcttctgggt ttccgttttc tcgaatgaaa aatgcaggtc      120

cgagcagtta actggcgggg gcaccattag caagtcactt agcatctctg gggccagtct      180

gcaaagcgag ggggcagcct taatgtgcct ccagcctgaa gtcctagaat gagcgcccgg      240

tgtcccaagc tggggcgcgc accccagatc ggagggcgcc gatgtacaga cagcaaactc      300

acccagtcta gtgcatgcct tcttaaacat cacgagactc taagaaaagg aaactgaaaa      360

cgggaaagtc cctctctcta acctggcact gcgtcgctgg cttggagaca ggtgacggtc      420

cctgcgggcc ttgtcctgat tggctgggca cgcgtttaat ataagtggag gcgtcgcgct      480

ggcgggcatt cctgaagctg acagcattcg ggccgag                               517


<210>  24
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  24
atgcatgcgt cgacctcgag ttaatcctca tcctgtctac ttgccac                     47


<210>  25
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  25
gcatgcatcg gccggggcgg cgactggtga gaggccacca tgggtgcgag agcgtcagta       60

ttaag                                                                   65


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  26
cccaagaacc caaggaaca                                                    19


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  27
agacaagata gaggaagagc aaaac                                             25


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  28
cggtgaggat cttcatgagg tagt                                              24


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  29
aacaccccag ccatgtacgt                                                   20


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  30
ccagccaggt ccagacgcag ga                                                22


<210>  31
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hook peptide

<400>  31

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


<210>  32
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hook peptide

<400>  32

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Thr Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Arg Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Thr Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Arg Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


<210>  33
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  34
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  35
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hook sequence

<400>  35
atgcaccgga ggagatcacg ctcttgtagg gaggaccaga aacctgtcac cggtgaccct       60

agcaaagact caaaagctca ggtgtccgct gccgaggctg gcattactgg aacatggtac      120

aatcagctcg ggagcacctt tattgtgact gctggagccg atggagccct caccggaaca      180

tacgaatctg ctgtgggaaa cgccgaatca cggtacgtcc tcactggccg atacgatagt      240

gcccctgcca ccgacggatc tgggactgcc ctgggatgga ctgtcgcttg gaaaaacaac      300

taccggaatg ctcattctgc cacaacatgg agtggacagt acgtgggagg cgctgaggct      360

agaatcaata cacagtggct gctcacatct ggcacaaccg aggcaaatgc ttggaaatcc      420

accctggtgg gacatgacac attcaccaaa gtgaaaccct ccgccgcttc aatcgatgcc      480

gccaaaaaag ccggagtcaa caacggcaat cctctggatg ccgtccagca ggtcgactat      540

ccgtacgacg taccagacta cgcagtcgga ccgatggacg atcagaggga cctcattagc      600

aacaacgaac agctgcctat gctgggacgg cgacctggag cccctgaatc caaatgctct      660

aggggagcac tgtacactgg cttctccatt ctcgtgacac tgctgctggc cgggcaggct      720

actactgctt acttcctgta ccagcagcag gggcggctgg acaaactcac tgtgacatct      780

cagaacctcc agctggaaaa tctgaggatg aaactgccca aaccccctaa acccgtgtcc      840

aaaatgagga tggccacacc tctgctcatg caggcactgc caatgggagc cctgccccag      900

gggcccatgc agaatgccac caagtatggc aacatgacag aggaccatgt gatgcacctg      960

ctccagaatg ctgaccccct gaaggtgtac ccgccactga aggggagctt cccggagaac     1020

ctgagacacc ttaagaacac catggagacc atagactgga aggtctttga gagctggatg     1080

caccattggc tcctgtttga aatgagcagg cactccttgg agcaaaagcc cactgacgct     1140

ccaccgaaag agtcactgga actggaggac ccgtcttctg ggctgggtgt gaccaagcag     1200

gatctgggcc cagtccccat gtga                                            1224


<210>  36
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hook sequence

<400>  36
gaccctagca aagactcaaa agctcaggtg tccgctgccg aggctggcat tactggaaca       60

tggtacaatc agctcgggag cacctttatt gtgactgctg gagccgatgg agccctcacc      120

ggaacatacg aatctgctgt gggaaacgcc gaatcacggt acgtcctcac tggccgatac      180

gatagtgccc ctgccaccga cggatctggg actgccctgg gatggactgt cgcttggaaa      240

aacaactacc ggaatgctca ttctgccaca acatggagtg gacagtacgt gggaggcgct      300

gaggctagaa tcaatacaca gtggctgctc acatctggca caaccgaggc aaatgcttgg      360

aaatccaccc tggtgggaca tgacacattc accaaagtga aaccctccgc cgcttcaatc      420

gatgccgcca aaaaagccgg agtcaacaac ggcaatcctc tggatgccgt ccagcag         477


<210>  37
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA TAG

<400>  37
tatccgtacg acgtaccaga ctacgca                                           27


<210>  38
<211>  1216
<212>  DNA
<213>  Homo sapiens

<400>  38
ggcctccgcg ccgggttttg ggcctcccgc gggcgccccc ctcctcacgg cgagcgctgc       60

cacgtcagac gaagggcgca gcgagcgtcc tgatccttcc gcccggacgc tcaggacagc      120

ggcccgctgc tcataagact cggccttaga accccagtat cagcagaagg acattttagg      180

acgggacttg ggtgactcta gggcactggt tttctttcca gagagcggaa caggcgagga      240

aaagtagtcc cttctcggcg attctgcgga gggatctccg tggggcggtg aacgccgatg      300

attatataag gacgcgccgg gtgtggcaca gctagttccg tcgcagccgg gatttgggtc      360

gcggttcttg tttgtggatc gctgtgatcg tcacttggtg agtagcgggc tgctgggctg      420

gccggggctt tcgtggccgc cgggccgctc ggtgggacgg aagcgtgtgg agagaccgcc      480

aagggctgta gtctgggtcc gcgagcaagg ttgccctgaa ctgggggttg gggggagcgc      540

agcaaaatgg cggctgttcc cgagtcttga atggaagacg cttgtgaggc gggctgtgag      600

gtcgttgaaa caaggtgggg ggcatggtgg gcggcaagaa cccaaggtct tgaggccttc      660

gctaatgcgg gaaagctctt attcgggtga gatgggctgg ggcaccatct ggggaccctg      720

acgtgaagtt tgtcactgac tggagaactc ggtttgtcgt ctgttgcggg ggcggcagtt      780

atggcggtgc cgttgggcag tgcacccgta cctttgggag cgcgcgccct cgtcgtgtcg      840

tgacgtcacc cgttctgttg gcttataatg cagggtgggg ccacctgccg gtaggtgtgc      900

ggtaggcttt tctccgtcgc aggacgcagg gttcgggcct agggtaggct ctcctgaatc      960

gacaggcgcc ggacctctgg tgaggggagg gataagtgag gcgtcagttt ctttggtcgg     1020

ttttatgtac ctatcttctt aagtagctga agctccggtt ttgaactatg cgctcggggt     1080

tggcgagtgt gttttgtgaa gttttttagg caccttttga aatgtaatca tttgggtcaa     1140

tatgtaattt tcagtgttag actagtaaat tgtccgctaa attctggccg tttttggctt     1200

ttttgttaga ccgatc                                                     1216


<210>  39
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  39
atggccctgc ctgtgacagc cctgctgctg cccctggctc tcctgctgca tgccgccaga       60

cccgctagcg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac      120

agagtgacca tcagctgccg ggccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagccggct ccacagcggc      240

gtgcccagca gattttctgg cagcggcagc ggcaccgact acagcctgac catctccaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct gccctacacc      360

ttcggcggag gcaccaagct ggaaatcacc ggcggaggcg gaagtggagg tggaggatct      420

ggcggcggag gctccgaagt gaagctgcag gaaagcggcc ctggcctcgt ggcccctagc      480

cagagcctgt ccgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      540

tggatcagac agcctcccag aaagggcctg gaatggctgg gcgtgatctg gggcagcgag      600

acaacctact acaacagcgc cctgaagtcc cggctgacca tcatcaagga caacagcaag      660

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      720

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      780

gtgaccgtgt ccagccatat ggccctgagc aacagcatca tgtacttcag ccacttcgtg      840

cccgtgtttc tgcccgccaa gcccaccacc acccctgccc ctagacctcc caccccagcc      900

ccaacaatcg ccagccagcc tctgtccctg cggcccgaag cctgtagacc tgctgccggc      960

ggagccgtgc acaccagagg cctggatatc tacatctggg cccctctggc cggcacctgt     1020

ggcgtgctgc tgctgagcct ggtgatcaca aagcggggca gaaagaagct gctgtacatc     1080

ttcaagcagc cattcatgcg gcccgtgcag accacccagg aagaggacgg ctgcagctgc     1140

cggttccccg aggaagagga aggcggctgc gaactgccca agctgtgcta cctgctggac     1200

ggcatcctgt tcatctatgg cgtgatcctg accgccctgt tcctgagagt gaagttcagc     1260

agaagcgccg acgcccctgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1320

ctgggcagac gggaagagta cgacgtgctg gacaagcgga gaggccggga ccctgagatg     1380

ggcggcaagc cccagcggcg gaagaaccct caggaaggcc tgtataacga actgcagaaa     1440

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggcg gagaggcaag     1500

ggccacgatg gcctgtac                                                   1518


<210>  40
<211>  1641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  40
atggccctgc ctgtgacagc cctgctgctg cccctcgctc tgctgctgca tgccgccaga       60

cccgctagcg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac      120

agagtgacca tcagctgccg ggccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagccggct ccacagcggc      240

gtgcccagca gattttctgg cagcggcagc ggcaccgact acagcctgac catctccaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct gccctacacc      360

ttcggcggag gcaccaagct ggaaatcacc ggcggaggcg gaagtggagg gggaggatct      420

ggcggcggag gctccgaagt gaagctgcag gaaagcggcc ctggcctggt ggcccctagc      480

cagagcctgt ccgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      540

tggatcagac agccccccag aaagggcctg gaatggctgg gcgtgatctg gggcagcgag      600

acaacctact acaacagcgc cctgaagtcc cggctgacca tcatcaagga caacagcaag      660

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      720

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      780

gtgaccgtgt ccagccatat ggccctgagc aacagcatca tgtacttcag ccacttcgtg      840

cccgtgtttc tgcccgccaa gcccaccacc acccctgccc ctagacctcc caccccagcc      900

ccaacaatcg ccagccagcc tctgtccctg aggcccgaag cctgtagacc tgctgccggc      960

ggagccgtgc acaccagagg cctggatatc tacatctggg cccctctggc cggcacctgt     1020

ggcgtgctgc tgctgagcct ggtgatcacc cggtccaagc ggagcagact gctgcactcc     1080

gactacatga acatgacccc cagacggcct ggccccaccc ggaagcacta ccagccttac     1140

gcccctcccc gggacttcgc cgcctacaga agcaagcggg gcagaaagaa gctgctgtac     1200

atcttcaagc agcccttcat gcggcccgtg cagaccaccc aggaagagga cggctgcagc     1260

tgccggttcc ccgaggaaga ggaaggcggc tgcgaactgc ccaagctgtg ctacctgctg     1320

gacggcatcc tgttcatcta tggcgtgatc ctgaccgccc tgttcctgag agtgaagttc     1380

agcagaagcg ccgacgcccc tgcctaccag cagggccaga accagctgta caacgagctg     1440

aacctgggca gacgggaaga gtacgacgtg ctggacaagc gcagaggccg ggaccctgag     1500

atgggcggca agcctcagcg gcggaagaac cctcaggaag gcctgtataa cgaactgcag     1560

aaagacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg gcggagaggc     1620

aagggccacg atggcctgta c                                               1641


<210>  41
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  41
gtctagaagt cagattgggg ttaaagagtc tgtccgtgat tgactaacag tcttaaatac       60

ttgatttgtt gttgttgttg tcctgtttgt ttaagaactt tacttcttta tccaatgaac      120

ggagtatctt gtgtcctgga ccctttgcaa gaacccttcc cctagcaaca gatgcgtcat      180

ctcaaaatat ttttctgatt ggccaaagag taattgattt gcattttaat ggtcagactc      240

tattacaccc cacattctct tttcttttat tcttgtctgt tctgcctcac tcccgagctc      300


<210>  42
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hook peptide

<400>  42

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Thr Gly Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu 
            20                  25                  30          


Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile 
        35                  40                  45              


Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala 
    50                  55                  60                  


Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser 
65                  70                  75                  80  


Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala 
                85                  90                  95      


Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly 
            100                 105                 110         


Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu 
        115                 120                 125             


Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly 
    130                 135                 140                 


His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala 
145                 150                 155                 160 


Ala Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln 
                165                 170                 175     


Gln Val Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Val Gly Pro Met 
            180                 185                 190         


Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met Leu 
        195                 200                 205             


Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala Leu 
    210                 215                 220                 


Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln Ala 
225                 230                 235                 240 


Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
                245                 250                 255     


Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys Leu 
            260                 265                 270         


Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu 
        275                 280                 285             


Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met Gln 
    290                 295                 300                 


Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His Leu 
305                 310                 315                 320 


Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser 
                325                 330                 335     


Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp 
            340                 345                 350         


Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met 
        355                 360                 365             


Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys Glu 
    370                 375                 380                 


Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln 
385                 390                 395                 400 


Asp Leu Gly Pro Val Pro Met 
                405         


<210>  43
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hook sequence

<400>  43
atgcaccgga ggagatcacg ctcttgtagg gaggaccaga aacctgtcac cggtgaccct       60

agcaaagact caaaagctca ggtgtccgct gccgaggctg gcattactgg aacatggtac      120

aatcagctcg ggagcacctt tattgtgact gctggagccg atggagccct caccggaaca      180

tacgaatctg ctgtgggaaa cgccgaatca cggtacgtcc tcactggccg atacgatagt      240

gcccctgcca ccgacggatc tgggactgcc ctgggatgga ctgtcgcttg gaaaaacaac      300

taccggaatg ctcattctgc cacaacatgg agtggacagt acgtgggagg cgctgaggct      360

agaatcaata cacagtggct gctcacatct ggcacaaccg aggcaaatgc ttggaaatcc      420

accctggtgg gacatgacac attcaccaaa gtgaaaccct ccgccgcttc aatcgatgcc      480

gccaaaaaag ccggagtcaa caacggcaat cctctggatg ccgtccagca ggtcgactat      540

ccgtacgacg taccagacta cgcagtcgga ccgatggacg atcagaggga cctcattagc      600

aacaacgaac agctgcctat gctgggacgg cgacctggag cccctgaatc caaatgctct      660

aggggagcac tgtacactgg cttctccatt ctcgtgacac tgctgctggc cgggcaggct      720

actactgctt acttcctgta ccagcagcag gggcggctgg acaaactcac tgtgacatct      780

cagaacctcc agctggaaaa tctgaggatg aaactgccca aaccccctaa acccgtgtcc      840

aaaatgagga tggccacacc tctgctcatg caggcactgc caatgggagc cctgccccag      900

gggcccatgc agaatgccac caagtatggc aacatgacag aggaccatgt gatgcacctg      960

ctccagaatg ctgaccccct gaaggtgtac ccgccactga aggggagctt cccggagaac     1020

ctgagacacc ttaagaacac catggagacc atagactgga aggtctttga gagctggatg     1080

caccattggc tcctgtttga aatgagcagg cactccttgg agcaaaagcc cactgacgct     1140

ccaccgaaag agtcactgga actggaggac ccgtcttctg ggctgggtgt gaccaagcag     1200

gatctgggcc cagtccccat gtga                                            1224


<210>  44
<211>  574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES

<400>  44
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacgcc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaacgt ctaggccccc cgaaccacgg      540

ggacgtggtt ttcctttgaa aaacacgatg ataa                                  574


<210>  45
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  45
atggccctgc ctgtgacagc cctgctgctg cccctggctc tcctgctgca tgccgccaga       60

cccgctagcg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac      120

agagtgacca tcagctgccg ggccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagccggct ccacagcggc      240

gtgcccagca gattttctgg cagcggcagc ggcaccgact acagcctgac catctccaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct gccctacacc      360

ttcggcggag gcaccaagct ggaaatcacc ggcggaggcg gaagtggagg tggaggatct      420

ggcggcggag gctccgaagt gaagctgcag gaaagcggcc ctggcctcgt ggcccctagc      480

cagagcctgt ccgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      540

tggatcagac agcctcccag aaagggcctg gaatggctgg gcgtgatctg gggcagcgag      600

acaacctact acaacagcgc cctgaagtcc cggctgacca tcatcaagga caacagcaag      660

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      720

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      780

gtgaccgtgt ccagccatat ggccctgagc aacagcatca tgtacttcag ccacttcgtg      840

cccgtgtttc tgcccgccaa gcccaccacc acccctgccc ctagacctcc caccccagcc      900

ccaacaatcg ccagccagcc tctgtccctg cggcccgaag cctgtagacc tgctgccggc      960

ggagccgtgc acaccagagg cctggatatc tacatctggg cccctctggc cggcacctgt     1020

ggcgtgctgc tgctgagcct ggtgatcacc accggtatgg acgagaaaac caccggctgg     1080

cggggaggcc acgtggtgga aggactggcc ggcgagctgg aacagctgcg ggccagactg     1140

gaacaccacc cccagggcca gagagagccc aagcggggca gaaagaagct gctgtacatc     1200

ttcaagcagc ccttcatgcg gcccgtgcag accacccagg aagaggacgg ctgcagctgc     1260

cggttccccg aggaagagga aggcggctgc gaactgccca agctgtgcta cctgctggac     1320

ggcatcctgt tcatctacgg cgtgatcctg accgccctgt tcctgagagt gaagttcagc     1380

agaagcgccg acgcccctgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1440

ctgggcagac gggaagagta cgacgtgctg gacaagcgga gaggccggga ccctgagatg     1500

ggcggcaagc cccagcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1560

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggcg gagaggcaag     1620

ggccacgatg gcctgtac                                                   1638


<210>  46
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser His Met Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Thr Gly 
            340                 345                 350         


Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
        355                 360                 365             


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
    370                 375                 380                 


Gln Gly Gln Arg Glu Pro Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
385                 390                 395                 400 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                405                 410                 415     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            420                 425                 430         


Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val 
        435                 440                 445             


Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    450                 455                 460                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
465                 470                 475                 480 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                485                 490                 495     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            500                 505                 510         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        515                 520                 525             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    530                 535                 540                 


Leu Tyr 
545     


<210>  47
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  47
atggccctgc ctgtgacagc cctgctgctg cccctggctc tcctgctgca tgccgccaga       60

cccgctagcg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac      120

agagtgacca tcagctgccg ggccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagccggct ccacagcggc      240

gtgcccagca gattttctgg cagcggcagc ggcaccgact acagcctgac catctccaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct gccctacacc      360

ttcggcggag gcaccaagct ggaaatcacc ggcggaggcg gaagtggagg tggaggatct      420

ggcggcggag gctccgaagt gaagctgcag gaaagcggcc ctggcctcgt ggcccctagc      480

cagagcctgt ccgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      540

tggatcagac agcctcccag aaagggcctg gaatggctgg gcgtgatctg gggcagcgag      600

acaacctact acaacagcgc cctgaagtcc cggctgacca tcatcaagga caacagcaag      660

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      720

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      780

gtgaccgtgt ccagccatat ggccctgagc aacagcatca tgtacttcag ccacttcgtg      840

cccgtgtttc tgcccgccaa gcccaccacc acccctgccc ctagacctcc caccccagcc      900

ccaacaatcg ccagccagcc tctgtccctg cggcccgaag cctgtagacc tgctgccggc      960

ggagccgtgc acaccagagg cctggatatc tacatctggg cccctctggc cggcacctgt     1020

ggcgtgctgc tgctgagcct ggtgatcaca aagcggggca gaaagaagct gctgtacatc     1080

ttcaagcagc ccttcatgcg gcccgtgcag accacccagg aagaggacgg ctgcagctgc     1140

cggttccccg aggaagagga aggcggctgc gagctgaccg gtatggacga gaaaaccacc     1200

ggctggcggg gaggccacgt ggtggaagga ctggccggcg agctggaaca gctgcgggcc     1260

agactggaac accaccccca gggccagagg gaacccccca agctgtgcta cctgctggac     1320

ggcatcctgt tcatctacgg cgtgatcctg accgccctgt tcctgagagt gaagttcagc     1380

agaagcgccg acgcccctgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1440

ctgggcagac gggaagagta cgacgtgctg gacaagcgga gaggccggga ccctgagatg     1500

ggcggcaagc cccagcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1560

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggcg gagaggcaag     1620

ggccacgatg gcctgtac                                                   1638


<210>  48
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser His Met Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Thr Gly Met Asp Glu Lys Thr Thr 
385                 390                 395                 400 


Gly Trp Arg Gly Gly His Val Val Glu Gly Leu Ala Gly Glu Leu Glu 
                405                 410                 415     


Gln Leu Arg Ala Arg Leu Glu His His Pro Gln Gly Gln Arg Glu Pro 
            420                 425                 430         


Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val 
        435                 440                 445             


Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    450                 455                 460                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
465                 470                 475                 480 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                485                 490                 495     


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
            500                 505                 510         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        515                 520                 525             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    530                 535                 540                 


Leu Tyr 
545     


<210>  49
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  49
atggccctgc ctgtgacagc cctgctgctg cccctggctc tcctgctgca tgccgccaga       60

cccgctagcg acatccagat gacccagacc accagcagcc tgagcgccag cctgggcgac      120

agagtgacca tcagctgccg ggccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagccggct ccacagcggc      240

gtgcccagca gattttctgg cagcggcagc ggcaccgact acagcctgac catctccaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct gccctacacc      360

ttcggcggag gcaccaagct ggaaatcacc ggcggaggcg gaagtggagg tggaggatct      420

ggcggcggag gctccgaagt gaagctgcag gaaagcggcc ctggcctcgt ggcccctagc      480

cagagcctgt ccgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      540

tggatcagac agcctcccag aaagggcctg gaatggctgg gcgtgatctg gggcagcgag      600

acaacctact acaacagcgc cctgaagtcc cggctgacca tcatcaagga caacagcaag      660

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      720

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      780

gtgaccgtgt ccagccatat ggccctgagc aacagcatca tgtacttcag ccacttcgtg      840

cccgtgtttc tgcccgccaa gcccaccacc acccctgccc ctagacctcc caccccagcc      900

ccaacaatcg ccagccagcc tctgtccctg cggcccgaag cctgtagacc tgctgccggc      960

ggagccgtgc acaccagagg cctggatatc tacatctggg cccctctggc cggcacctgt     1020

ggcgtgctgc tgctgagcct ggtgatcaca aagcggggca gaaagaagct gctgtacatc     1080

ttcaagcagc ccttcatgcg gcccgtgcag accacccagg aagaggacgg ctgcagctgc     1140

cggttccccg aggaagagga aggcggctgc gaactgccca agctgtgcta cctgctggac     1200

ggcatcctgt tcatctacgg cgtgatcctg accgccctgt tcctgagagt gaagttcagc     1260

agaagcgccg acgcccctgc ctaccagcag ggccagaacc agctgtacaa cgagctgaac     1320

ctgggcagac gggaagagta cgacgtgctg gacaagcgga gaggccggga ccctgagatg     1380

ggcggcaagc cccagcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1440

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggcg gagaggcaag     1500

ggccacgatg gcctgtacac cggtatggac gagaaaacca ccggctggcg gggaggccac     1560

gtggtggaag gactggccgg cgagctggaa cagctgcggg ccagactgga acaccacccc     1620

cagggccaga gggaaccc                                                   1638


<210>  50
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser His Met Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Pro Lys Leu Cys Tyr Leu Leu Asp 
385                 390                 395                 400 


Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu Arg 
                405                 410                 415     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            420                 425                 430         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        435                 440                 445             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    450                 455                 460                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Thr Gly Met Asp Glu Lys 
            500                 505                 510         


Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly Leu Ala Gly Glu 
        515                 520                 525             


Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro Gln Gly Gln Arg 
    530                 535                 540                 


Glu Pro 
545     


<210>  51
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser His Met Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Pro Lys Leu Cys Tyr Leu Leu Asp 
385                 390                 395                 400 


Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu Arg 
                405                 410                 415     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            420                 425                 430         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        435                 440                 445             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    450                 455                 460                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            500                 505     


<210>  52
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  52
aaccattagg agtagcaccc accaagg                                           27


