               SEQUENCE LISTING

<110> Alderys

<120> Method for producing acetoin

<130> PR73134/KLP/GGJ/gg

<150> EP14306205.7
<151> 2014-07-25

<160> 52

<170> BiSSAP 1.3

<210> 1
<211> 1716
<212> DNA
<213> Bacillus subtilis

<400> 1
atgtctacca aagcaacaaa agagcaaaag agccttgtga agaatagagg tgcagaactt      60

gtcgttgatt gcttggtaga acagggagtc actcacgttt tcgggatacc cggcgctaaa     120

atcgacgccg tgtttgacgc tttacaggat aagggaccag agatcattgt tgctagacat     180

gaacagaatg cagcgttcat ggctcaagct gtaggtagac ttactgggaa acccggtgtg     240

gttttggtta ctagtggacc aggtgcatca aatctagcaa caggtttgtt aacagcgaat     300

acagagggag atcctgttgt tgcattagca ggaaacgtta tcagagcgga tagactgaaa     360

agaacccatc aatcattgga taatgctgca ttatttcagc caattacgaa atattccgtc     420

gaagtacagg atgtgaagaa catacctgaa gctgtaacta atgcgtttcg tatagcttct     480

gctggtcaag ctggtgcagc ttttgtttcg tttccgcaag acgttgtcaa cgaggttacg     540

aacactaaga atgtgagagc agtagcagcc ccaaaattag gaccagctgc tgatgatgct     600

atatcagctg ctattgctaa gattcagaca gccaaactac ctgttgtctt agtaggtatg     660

aaaggtggca ggccagaagc aatcaaggca gttagaaaac tgttgaagaa ggttcaattg     720

ccgtttgtgg aaacctatca agccgcaggg actttgtcta gggatctaga agatcaatac     780

ttcggtagaa tagggttgtt cagaaatcaa cctggcgact tgttactgga acaagccgat     840

gtcgtgctta caattggtta cgatccgatt gaatatgacc ccaaattttg gaatattaat     900

ggtgatagga ctattatcca cttagacgag attattgccg atattgacca tgcttatcaa     960

cctgatctgg aactgatagg tgatattcca agtactatca accatataga gcatgatgcc    1020

gtcaaagtgg aatttgccga aagagaacag aagatcctat ccgatctaaa gcagtacatg    1080

catgaaggcg aacaagttcc agcagattgg aaatccgata gagcacatcc attggaaatt    1140

gtcaaagaat tgagaaatgc agttgatgac catgttacag ttacttgtga cataggtagt    1200

cacgctattt ggatgtctag gtacttcaga tcttatgagc cattaacgtt gatgatatcc    1260

aatggcatgc aaacccttgg agtcgcttta ccatgggcca ttggtgcgtc gttagtaaag    1320

ccaggagaga aagtcgtttc tgtgtcaggt gatggtggtt tcttgttctc tgccatggaa    1380

ttggaaaccg ccgttcgttt gaaagcccct atagtacaca tcgtgtggaa tgattcgacc    1440

tatgacatgg tcgcgtttca acaattgaag aagtacaacc gtacttcagc tgttgatttc    1500

ggcaacattg acattgtgaa gtacgcggaa agctttggcg ccacaggcct aagagtcgaa    1560

tcacctgatc aattagcaga tgtacttagg caagggatga acgctgaagg acctgtaatt    1620

atcgacgtac ctgttgacta tagcgacaac atcaatttag ccagtgataa attacccaaa    1680

gagtttggtg agctaatgaa aacgaaagct ttgtaa                              1716


<210> 2
<211> 571
<212> PRT
<213> Bacillus subtilis

<400> 2
Met Ser Thr Lys Ala Thr Lys Glu Gln Lys Ser Leu Val Lys Asn Arg 
1               5                   10                  15      
Gly Ala Glu Leu Val Val Asp Cys Leu Val Glu Gln Gly Val Thr His 
            20                  25                  30          
Val Phe Gly Ile Pro Gly Ala Lys Ile Asp Ala Val Phe Asp Ala Leu 
        35                  40                  45              
Gln Asp Lys Gly Pro Glu Ile Ile Val Ala Arg His Glu Gln Asn Ala 
    50                  55                  60                  
Ala Phe Met Ala Gln Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val 
65                  70                  75                  80  
Val Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu 
                85                  90                  95      
Leu Thr Ala Asn Thr Glu Gly Asp Pro Val Val Ala Leu Ala Gly Asn 
            100                 105                 110         
Val Ile Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Leu Asp Asn 
        115                 120                 125             
Ala Ala Leu Phe Gln Pro Ile Thr Lys Tyr Ser Val Glu Val Gln Asp 
    130                 135                 140                 
Val Lys Asn Ile Pro Glu Ala Val Thr Asn Ala Phe Arg Ile Ala Ser 
145                 150                 155                 160 
Ala Gly Gln Ala Gly Ala Ala Phe Val Ser Phe Pro Gln Asp Val Val 
                165                 170                 175     
Asn Glu Val Thr Asn Thr Lys Asn Val Arg Ala Val Ala Ala Pro Lys 
            180                 185                 190         
Leu Gly Pro Ala Ala Asp Asp Ala Ile Ser Ala Ala Ile Ala Lys Ile 
        195                 200                 205             
Gln Thr Ala Lys Leu Pro Val Val Leu Val Gly Met Lys Gly Gly Arg 
    210                 215                 220                 
Pro Glu Ala Ile Lys Ala Val Arg Lys Leu Leu Lys Lys Val Gln Leu 
225                 230                 235                 240 
Pro Phe Val Glu Thr Tyr Gln Ala Ala Gly Thr Leu Ser Arg Asp Leu 
                245                 250                 255     
Glu Asp Gln Tyr Phe Gly Arg Ile Gly Leu Phe Arg Asn Gln Pro Gly 
            260                 265                 270         
Asp Leu Leu Leu Glu Gln Ala Asp Val Val Leu Thr Ile Gly Tyr Asp 
        275                 280                 285             
Pro Ile Glu Tyr Asp Pro Lys Phe Trp Asn Ile Asn Gly Asp Arg Thr 
    290                 295                 300                 
Ile Ile His Leu Asp Glu Ile Ile Ala Asp Ile Asp His Ala Tyr Gln 
305                 310                 315                 320 
Pro Asp Leu Glu Leu Ile Gly Asp Ile Pro Ser Thr Ile Asn His Ile 
                325                 330                 335     
Glu His Asp Ala Val Lys Val Glu Phe Ala Glu Arg Glu Gln Lys Ile 
            340                 345                 350         
Leu Ser Asp Leu Lys Gln Tyr Met His Glu Gly Glu Gln Val Pro Ala 
        355                 360                 365             
Asp Trp Lys Ser Asp Arg Ala His Pro Leu Glu Ile Val Lys Glu Leu 
    370                 375                 380                 
Arg Asn Ala Val Asp Asp His Val Thr Val Thr Cys Asp Ile Gly Ser 
385                 390                 395                 400 
His Ala Ile Trp Met Ser Arg Tyr Phe Arg Ser Tyr Glu Pro Leu Thr 
                405                 410                 415     
Leu Met Ile Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu Pro Trp 
            420                 425                 430         
Ala Ile Gly Ala Ser Leu Val Lys Pro Gly Glu Lys Val Val Ser Val 
        435                 440                 445             
Ser Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala 
    450                 455                 460                 
Val Arg Leu Lys Ala Pro Ile Val His Ile Val Trp Asn Asp Ser Thr 
465                 470                 475                 480 
Tyr Asp Met Val Ala Phe Gln Gln Leu Lys Lys Tyr Asn Arg Thr Ser 
                485                 490                 495     
Ala Val Asp Phe Gly Asn Ile Asp Ile Val Lys Tyr Ala Glu Ser Phe 
            500                 505                 510         
Gly Ala Thr Gly Leu Arg Val Glu Ser Pro Asp Gln Leu Ala Asp Val 
        515                 520                 525             
Leu Arg Gln Gly Met Asn Ala Glu Gly Pro Val Ile Ile Asp Val Pro 
    530                 535                 540                 
Val Asp Tyr Ser Asp Asn Ile Asn Leu Ala Ser Asp Lys Leu Pro Lys 
545                 550                 555                 560 
Glu Phe Gly Glu Leu Met Lys Thr Lys Ala Leu 
                565                 570     

<210> 3
<211> 1995
<212> DNA
<213> Nicotiana tabacum

<400> 3
atggctgctg ctgcagctgc tccatctcca tctttttcta aaaccttgtc ctcctcctct      60

tccaaatctt ctactttgtt gccaagatct actttcccat ttccacatca tccacataag     120

actactccac caccattgca tttgactcca actcatattc actcccaaag aagaagattc     180

accatctcca acgttatttc taccacccaa aaggtttctg aaactcaaaa ggctgaaacc     240

ttcgtttcta gatttgctcc agatgaacct agaaagggtt ctgatgtttt ggttgaagct     300

ttggaaagag aaggtgttac cgatgttttt gcttatccag gtggtgcttc tatggaaatt     360

catcaagctt tgaccagatc ctccatcatt agaaatgttt tgccaagaca tgaacaaggt     420

ggtgttttcg ctgctgaagg ttatgctaga gctactggtt ttccaggtgt atgtattgct     480

acttctggtc caggtgctac taatttggtt tctggtttgg ctgatgcttt gttggattct     540

gttccaatcg ttgctattac tggtcaagtt ccaagaagaa tgattggtac agatgctttc     600

caagaaaccc caattgtcga agttactaga tctattacca agcacaacta cttggttatg     660

gacgttgaag atatcccaag agttgttaga gaagcatttt tcttggctag atctggtaga     720

ccaggtccag ttttgattga tgttccaaag gatatccaac aacaattggt tatcccagat     780

tgggaccaac ctatgagatt gccaggttat atgtctagat tgccaaagtt gccaaacgaa     840

atgttgttag aacaaatcgt cagattgatc tccgaatcta aaaagccagt cttgtatgtt     900

ggtggtggtt gttctcaatc tagtgaagaa ttgagaagat tcgtcgaatt gaccggtatt     960

ccagttgctt ctacattgat gggtttgggt gcttttccaa ctggtgatga attgtctttg    1020

tctatgttgg gtatgcacgg tactgtttat gctaattacg ctgttgattc ctccgatttg    1080

ttgttagctt ttggtgttag attcgatgat agagtcactg gtaagttgga agcttttgct    1140

tctagagcta agatcgttca tatcgacatt gattccgctg aaatcggtaa aaacaagcaa    1200

ccacatgttt ctatttgcgc cgatattaag ttggcattgc aaggtttgaa cagtatcttg    1260

gaatccaaag aaggtaaatt gaagttggac ttctctgctt ggagacaaga attgacagtt    1320

caaaaggtta agtacccatt gaacttcaag actttcggtg atgctattcc accacaatac    1380

gctattcaag ttttggatga attgaccaac ggttccgcta ttatttcaac tggtgttggt    1440

caacatcaaa tgtgggctgc tcaatattac aagtacagaa aacctagaca atggttgact    1500

tctggtggtt taggtgctat gggttttggt ttgccagctg ctattggtgc tgctgttggt    1560

agacctgatg aagttgttgt agatattgat ggtgacggtt ccttcattat gaacgtccaa    1620

gaattggcta ccatcaaggt tgaaaatttg ccagtcaaga tcatgttatt gaacaatcaa    1680

cacttgggta tggtcgtcca atgggaagat agattttaca aagctaatag agcccacacc    1740

tacttgggta atccatctaa tgaagctgaa atcttcccaa acatgttgaa gtttgctgaa    1800

gcttgtggtg ttccagctgc aagagttact catagagatg atttgagagc tgccatccaa    1860

aagatgttgg atactccagg tccatacttg ttggatgtta ttgtcccaca tcaagaacat    1920

gtcttgccaa tgattccatc tggtggtgcc tttaaagatg ttattactga aggtgacggt    1980

agatcctctt actga                                                     1995


<210> 4
<211> 664
<212> PRT
<213> Nicotiana tabacum

<400> 4
Met Ala Ala Ala Ala Ala Ala Pro Ser Pro Ser Phe Ser Lys Thr Leu 
1               5                   10                  15      
Ser Ser Ser Ser Ser Lys Ser Ser Thr Leu Leu Pro Arg Ser Thr Phe 
            20                  25                  30          
Pro Phe Pro His His Pro His Lys Thr Thr Pro Pro Pro Leu His Leu 
        35                  40                  45              
Thr Pro Thr His Ile His Ser Gln Arg Arg Arg Phe Thr Ile Ser Asn 
    50                  55                  60                  
Val Ile Ser Thr Thr Gln Lys Val Ser Glu Thr Gln Lys Ala Glu Thr 
65                  70                  75                  80  
Phe Val Ser Arg Phe Ala Pro Asp Glu Pro Arg Lys Gly Ser Asp Val 
                85                  90                  95      
Leu Val Glu Ala Leu Glu Arg Glu Gly Val Thr Asp Val Phe Ala Tyr 
            100                 105                 110         
Pro Gly Gly Ala Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Ser 
        115                 120                 125             
Ile Ile Arg Asn Val Leu Pro Arg His Glu Gln Gly Gly Val Phe Ala 
    130                 135                 140                 
Ala Glu Gly Tyr Ala Arg Ala Thr Gly Phe Pro Gly Val Cys Ile Ala 
145                 150                 155                 160 
Thr Ser Gly Pro Gly Ala Thr Asn Leu Val Ser Gly Leu Ala Asp Ala 
                165                 170                 175     
Leu Leu Asp Ser Val Pro Ile Val Ala Ile Thr Gly Gln Val Pro Arg 
            180                 185                 190         
Arg Met Ile Gly Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val 
        195                 200                 205             
Thr Arg Ser Ile Thr Lys His Asn Tyr Leu Val Met Asp Val Glu Asp 
    210                 215                 220                 
Ile Pro Arg Val Val Arg Glu Ala Phe Phe Leu Ala Arg Ser Gly Arg 
225                 230                 235                 240 
Pro Gly Pro Val Leu Ile Asp Val Pro Lys Asp Ile Gln Gln Gln Leu 
                245                 250                 255     
Val Ile Pro Asp Trp Asp Gln Pro Met Arg Leu Pro Gly Tyr Met Ser 
            260                 265                 270         
Arg Leu Pro Lys Leu Pro Asn Glu Met Leu Leu Glu Gln Ile Val Arg 
        275                 280                 285             
Leu Ile Ser Glu Ser Lys Lys Pro Val Leu Tyr Val Gly Gly Gly Cys 
    290                 295                 300                 
Ser Gln Ser Ser Glu Glu Leu Arg Arg Phe Val Glu Leu Thr Gly Ile 
305                 310                 315                 320 
Pro Val Ala Ser Thr Leu Met Gly Leu Gly Ala Phe Pro Thr Gly Asp 
                325                 330                 335     
Glu Leu Ser Leu Ser Met Leu Gly Met His Gly Thr Val Tyr Ala Asn 
            340                 345                 350         
Tyr Ala Val Asp Ser Ser Asp Leu Leu Leu Ala Phe Gly Val Arg Phe 
        355                 360                 365             
Asp Asp Arg Val Thr Gly Lys Leu Glu Ala Phe Ala Ser Arg Ala Lys 
    370                 375                 380                 
Ile Val His Ile Asp Ile Asp Ser Ala Glu Ile Gly Lys Asn Lys Gln 
385                 390                 395                 400 
Pro His Val Ser Ile Cys Ala Asp Ile Lys Leu Ala Leu Gln Gly Leu 
                405                 410                 415     
Asn Ser Ile Leu Glu Ser Lys Glu Gly Lys Leu Lys Leu Asp Phe Ser 
            420                 425                 430         
Ala Trp Arg Gln Glu Leu Thr Val Gln Lys Val Lys Tyr Pro Leu Asn 
        435                 440                 445             
Phe Lys Thr Phe Gly Asp Ala Ile Pro Pro Gln Tyr Ala Ile Gln Val 
    450                 455                 460                 
Leu Asp Glu Leu Thr Asn Gly Ser Ala Ile Ile Ser Thr Gly Val Gly 
465                 470                 475                 480 
Gln His Gln Met Trp Ala Ala Gln Tyr Tyr Lys Tyr Arg Lys Pro Arg 
                485                 490                 495     
Gln Trp Leu Thr Ser Gly Gly Leu Gly Ala Met Gly Phe Gly Leu Pro 
            500                 505                 510         
Ala Ala Ile Gly Ala Ala Val Gly Arg Pro Asp Glu Val Val Val Asp 
        515                 520                 525             
Ile Asp Gly Asp Gly Ser Phe Ile Met Asn Val Gln Glu Leu Ala Thr 
    530                 535                 540                 
Ile Lys Val Glu Asn Leu Pro Val Lys Ile Met Leu Leu Asn Asn Gln 
545                 550                 555                 560 
His Leu Gly Met Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn 
                565                 570                 575     
Arg Ala His Thr Tyr Leu Gly Asn Pro Ser Asn Glu Ala Glu Ile Phe 
            580                 585                 590         
Pro Asn Met Leu Lys Phe Ala Glu Ala Cys Gly Val Pro Ala Ala Arg 
        595                 600                 605             
Val Thr His Arg Asp Asp Leu Arg Ala Ala Ile Gln Lys Met Leu Asp 
    610                 615                 620                 
Thr Pro Gly Pro Tyr Leu Leu Asp Val Ile Val Pro His Gln Glu His 
625                 630                 635                 640 
Val Leu Pro Met Ile Pro Ser Gly Gly Ala Phe Lys Asp Val Ile Thr 
                645                 650                 655     
Glu Gly Asp Gly Arg Ser Ser Tyr 
            660                 

<210> 5
<211> 1746
<212> DNA
<213> Paenibacillus polymyxa

<400> 5
atgtccgcac aaatacctga agttagaagt acaaatgaat tgagagaaaa atggatgaag      60

cctgaagtaa tcactggttc cgaaatattg ttaagatcat tgttattgga aggtgtcgat     120

tgtgtatttg gttatccagg tggtgctgtc ttgtacatct atgatgcaat gtacggtttt     180

aaagacttca agcatgtttt aaccagacac gaacaaggtg ctatacatgc tgcagatggt     240

tatgccagag cttccggtaa agtaggtgtt tgcatcgcaa caagtggtcc aggtgccacc     300

aatttggtta ctggtatcgc aacagccttt atggattctg ttcctttggt tgtcattact     360

ggtaacgtca tttcttcatt aatcggtaca gatgcattcc aagaagccga cataactggt     420

atcacaatgc caataactaa gcactcatat ttggttagag atgtcgaaga cttgcctaga     480

ataatccatg aagcatttca catagcaaat acaggtagaa agggtccagt tttgatagat     540

atccctaaag acatatccgc cgctcaaacc ttattcgtac cacaaaccgg tcctgttact     600

atgagaggtt acaacccaaa ggttttgcct aacaagatac aattggataa attgacacaa     660

gccatctccg aagctgaaag accattcatt ttggcaggtg gtggtgtagt ttatagtggt     720

ggtcatgaag ccttatacga atttgttaga aagactgaaa tccctatcac tacaacctta     780

ttgggtttag gtggtttccc atcaggtcat gaattgtgga ctggtatgcc tggtatgcac     840

ggtacataca cctccaatca agcaatacaa caatctgatt tgttgatctg tattggtgct     900

agatttgatg acagagttac tggtaaattg gatggtttcg caccacaagc caaaattgta     960

catatagata tcgaccctgc agaaataggt aaaaatgttg cagccgatat tccaatagta    1020

ggtgacgtta aggctgtctt agaattattg aaccaagatg ttaagagagc cgatagagct    1080

gacgcatgga gagcacaaat ccaacattgg aagaacgaaa agccatattc ctacaaggat    1140

agtgaaacag ttttgaaacc tcaatgggtc gtagaattat tggatgaaac tacaaagggt    1200

ggtgctattg tcaccactga cgtaggtcaa caccaaatgt gggctgcaca atactacaag    1260

tttaatcaac caagatcatg ggttacatca ggtggtttag gtactatggg ttttggtttc    1320

ccatctgcta ttggtgcaca aatggccaat cctgatagat tggttatctc tattaacggt    1380

gacggtggta tgcaaatgtg ttcacaagaa ttagctattt gcgctattaa taacatccca    1440

gtaaagatcg ttatcattaa taaccaagtt ttgggtatgg tcagacaatg gcaagaattg    1500

atctataaca acagatactc tcatattgat ttggctggtt cacctgactt tgtcaaattg    1560

gccgaagcct atggtgtaaa gggtttaaga gcaaccaata aggaagaagc cagaagagct    1620

tggcaagaag cattggatac tccaggtcct gttgtcgtag aatttgttgt ctctaaagaa    1680

gaaaacgttt atccaatggt tacacaaggt tccacaatag accaaatgtt gatgggtgac    1740

gaatga                                                               1746


<210> 6
<211> 581
<212> PRT
<213> Paenibacillus polymyxa

<400> 6
Met Ser Ala Gln Ile Pro Glu Val Arg Ser Thr Asn Glu Leu Arg Glu 
1               5                   10                  15      
Lys Trp Met Lys Pro Glu Val Ile Thr Gly Ser Glu Ile Leu Leu Arg 
            20                  25                  30          
Ser Leu Leu Leu Glu Gly Val Asp Cys Val Phe Gly Tyr Pro Gly Gly 
        35                  40                  45              
Ala Val Leu Tyr Ile Tyr Asp Ala Met Tyr Gly Phe Lys Asp Phe Lys 
    50                  55                  60                  
His Val Leu Thr Arg His Glu Gln Gly Ala Ile His Ala Ala Asp Gly 
65                  70                  75                  80  
Tyr Ala Arg Ala Ser Gly Lys Val Gly Val Cys Ile Ala Thr Ser Gly 
                85                  90                  95      
Pro Gly Ala Thr Asn Leu Val Thr Gly Ile Ala Thr Ala Phe Met Asp 
            100                 105                 110         
Ser Val Pro Leu Val Val Ile Thr Gly Asn Val Ile Ser Ser Leu Ile 
        115                 120                 125             
Gly Thr Asp Ala Phe Gln Glu Ala Asp Ile Thr Gly Ile Thr Met Pro 
    130                 135                 140                 
Ile Thr Lys His Ser Tyr Leu Val Arg Asp Val Glu Asp Leu Pro Arg 
145                 150                 155                 160 
Ile Ile His Glu Ala Phe His Ile Ala Asn Thr Gly Arg Lys Gly Pro 
                165                 170                 175     
Val Leu Ile Asp Ile Pro Lys Asp Ile Ser Ala Ala Gln Thr Leu Phe 
            180                 185                 190         
Val Pro Gln Thr Gly Pro Val Thr Met Arg Gly Tyr Asn Pro Lys Val 
        195                 200                 205             
Leu Pro Asn Lys Ile Gln Leu Asp Lys Leu Thr Gln Ala Ile Ser Glu 
    210                 215                 220                 
Ala Glu Arg Pro Phe Ile Leu Ala Gly Gly Gly Val Val Tyr Ser Gly 
225                 230                 235                 240 
Gly His Glu Ala Leu Tyr Glu Phe Val Arg Lys Thr Glu Ile Pro Ile 
                245                 250                 255     
Thr Thr Thr Leu Leu Gly Leu Gly Gly Phe Pro Ser Gly His Glu Leu 
            260                 265                 270         
Trp Thr Gly Met Pro Gly Met His Gly Thr Tyr Thr Ser Asn Gln Ala 
        275                 280                 285             
Ile Gln Gln Ser Asp Leu Leu Ile Cys Ile Gly Ala Arg Phe Asp Asp 
    290                 295                 300                 
Arg Val Thr Gly Lys Leu Asp Gly Phe Ala Pro Gln Ala Lys Ile Val 
305                 310                 315                 320 
His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Val Ala Ala Asp 
                325                 330                 335     
Ile Pro Ile Val Gly Asp Val Lys Ala Val Leu Glu Leu Leu Asn Gln 
            340                 345                 350         
Asp Val Lys Arg Ala Asp Arg Ala Asp Ala Trp Arg Ala Gln Ile Gln 
        355                 360                 365             
His Trp Lys Asn Glu Lys Pro Tyr Ser Tyr Lys Asp Ser Glu Thr Val 
    370                 375                 380                 
Leu Lys Pro Gln Trp Val Val Glu Leu Leu Asp Glu Thr Thr Lys Gly 
385                 390                 395                 400 
Gly Ala Ile Val Thr Thr Asp Val Gly Gln His Gln Met Trp Ala Ala 
                405                 410                 415     
Gln Tyr Tyr Lys Phe Asn Gln Pro Arg Ser Trp Val Thr Ser Gly Gly 
            420                 425                 430         
Leu Gly Thr Met Gly Phe Gly Phe Pro Ser Ala Ile Gly Ala Gln Met 
        435                 440                 445             
Ala Asn Pro Asp Arg Leu Val Ile Ser Ile Asn Gly Asp Gly Gly Met 
    450                 455                 460                 
Gln Met Cys Ser Gln Glu Leu Ala Ile Cys Ala Ile Asn Asn Ile Pro 
465                 470                 475                 480 
Val Lys Ile Val Ile Ile Asn Asn Gln Val Leu Gly Met Val Arg Gln 
                485                 490                 495     
Trp Gln Glu Leu Ile Tyr Asn Asn Arg Tyr Ser His Ile Asp Leu Ala 
            500                 505                 510         
Gly Ser Pro Asp Phe Val Lys Leu Ala Glu Ala Tyr Gly Val Lys Gly 
        515                 520                 525             
Leu Arg Ala Thr Asn Lys Glu Glu Ala Arg Arg Ala Trp Gln Glu Ala 
    530                 535                 540                 
Leu Asp Thr Pro Gly Pro Val Val Val Glu Phe Val Val Ser Lys Glu 
545                 550                 555                 560 
Glu Asn Val Tyr Pro Met Val Thr Gln Gly Ser Thr Ile Asp Gln Met 
                565                 570                 575     
Leu Met Gly Asp Glu 
            580     

<210> 7
<211> 860
<212> DNA
<213> Brevibacillus brevis

<400> 7
atgggtaaga agaacattat tacctctatc acctccttgg ctttggttgc tggtttgtct      60

ttgactgctt ttgctgctac tactgctact gttccagctc caccagctaa acaagaatct     120

aaaccagctg ttgctgctaa tccagctcct aagaatgttt tgttccaata ctctaccatc     180

aacgccttga tgttgggtca atttgaaggt gatttgacct tgaaggactt gaagttgaga     240

ggtgatatgg gtttgggtac tatcaatgat ttggacggtg aaatgatcca aatgggtact     300

aagttctacc aaatcgattc taccggtaag ttgtctgaat tgccagaatc tgttaagact     360

ccattcgctg ttactactca cttcgaacct aaagaaaaga ctaccttgac caacgtccaa     420

gactacaatc aattgaccaa gatgttggaa gaaaagttcg aaaacaagaa cgttttctac     480

gccgttaagt tgactggtac tttcaaaatg gttaaggcta gaaccgttcc taagcaaact     540

agaccatatc cacaattgac tgaagtcacc aagaagcaat ccgaatttga attcaagaac     600

gtcaagggta ctttgatcgg tttttacact ccaaattatg ctgctgcttt gaacgttcca     660

ggttttcact tgcatttcat taccgaagat aagacctctg gtggtcatgt tttgaacttg     720

caatttgata acgccaactt ggaaatctcc ccaatccatg aatttgatgt tcaattgcca     780

cacaccgatg atttcgctca ttctgatttg actcaagtta ctacctccca agttcatcaa     840

gctgaatctg aaagaaagta                                                 860


<210> 8
<211> 286
<212> PRT
<213> Brevibacillus brevis

<400> 8
Met Gly Lys Lys Asn Ile Ile Thr Ser Ile Thr Ser Leu Ala Leu Val 
1               5                   10                  15      
Ala Gly Leu Ser Leu Thr Ala Phe Ala Ala Thr Thr Ala Thr Val Pro 
            20                  25                  30          
Ala Pro Pro Ala Lys Gln Glu Ser Lys Pro Ala Val Ala Ala Asn Pro 
        35                  40                  45              
Ala Pro Lys Asn Val Leu Phe Gln Tyr Ser Thr Ile Asn Ala Leu Met 
    50                  55                  60                  
Leu Gly Gln Phe Glu Gly Asp Leu Thr Leu Lys Asp Leu Lys Leu Arg 
65                  70                  75                  80  
Gly Asp Met Gly Leu Gly Thr Ile Asn Asp Leu Asp Gly Glu Met Ile 
                85                  90                  95      
Gln Met Gly Thr Lys Phe Tyr Gln Ile Asp Ser Thr Gly Lys Leu Ser 
            100                 105                 110         
Glu Leu Pro Glu Ser Val Lys Thr Pro Phe Ala Val Thr Thr His Phe 
        115                 120                 125             
Glu Pro Lys Glu Lys Thr Thr Leu Thr Asn Val Gln Asp Tyr Asn Gln 
    130                 135                 140                 
Leu Thr Lys Met Leu Glu Glu Lys Phe Glu Asn Lys Asn Val Phe Tyr 
145                 150                 155                 160 
Ala Val Lys Leu Thr Gly Thr Phe Lys Met Val Lys Ala Arg Thr Val 
                165                 170                 175     
Pro Lys Gln Thr Arg Pro Tyr Pro Gln Leu Thr Glu Val Thr Lys Lys 
            180                 185                 190         
Gln Ser Glu Phe Glu Phe Lys Asn Val Lys Gly Thr Leu Ile Gly Phe 
        195                 200                 205             
Tyr Thr Pro Asn Tyr Ala Ala Ala Leu Asn Val Pro Gly Phe His Leu 
    210                 215                 220                 
His Phe Ile Thr Glu Asp Lys Thr Ser Gly Gly His Val Leu Asn Leu 
225                 230                 235                 240 
Gln Phe Asp Asn Ala Asn Leu Glu Ile Ser Pro Ile His Glu Phe Asp 
                245                 250                 255     
Val Gln Leu Pro His Thr Asp Asp Phe Ala His Ser Asp Leu Thr Gln 
            260                 265                 270         
Val Thr Thr Ser Gln Val His Gln Ala Glu Ser Glu Arg Lys 
        275                 280                 285     

<210> 9
<211> 783
<212> DNA
<213> Enterobacter aerogenes

<400> 9
atgatgatgc actcctccgc ctgcgactgt gaagcaagtt tatgcgaaac attgagaggt      60

ttttccgcca agcacccaga ttccgttata tatcaaacat ccttgatgag tgctttgtta     120

tctggtgtct acgaaggtga cactacaatc gcagacttgt tagctcatgg tgactttggt     180

ttgggtactt ttaatgaatt agacggtgaa atgatcgcat tttcttcaca agtttaccaa     240

ttgagagctg atggttcagc aagagctgca aaaccagaac aaaagacacc ttttgcagtc     300

atgacctggt tccaaccaca atacagaaaa acttttgatg ccccagtttc aagacaacaa     360

attcacgatg taatagacca acaaatccct tcagataatt tgttttgtgc cttgagaata     420

gacggtaact tcagacatgc tcacaccaga actgttccaa gacaaactcc accttataga     480

gccatgacag atgtattgga tgaccaacct gtttttagat tcaatcaaag agaaggtgtt     540

ttagtcggtt ttagaacccc acaacacatg caaggtatca acgtagcagg ttatcatgaa     600

cacttcatta ctgatgacag acaaggtggt ggtcatttgt tagattacca attggaatcc     660

ggtgttttga cattcggtga aatccacaag ttgatgattg atttgccagc cgacagtgct     720

ttcttacaag ccaacttaca cccatcaaac ttagacgccg caatcagatc agtagaaaac     780

taa                                                                   783


<210> 10
<211> 260
<212> PRT
<213> Enterobacter aerogenes

<400> 10
Met Met Met His Ser Ser Ala Cys Asp Cys Glu Ala Ser Leu Cys Glu 
1               5                   10                  15      
Thr Leu Arg Gly Phe Ser Ala Lys His Pro Asp Ser Val Ile Tyr Gln 
            20                  25                  30          
Thr Ser Leu Met Ser Ala Leu Leu Ser Gly Val Tyr Glu Gly Asp Thr 
        35                  40                  45              
Thr Ile Ala Asp Leu Leu Ala His Gly Asp Phe Gly Leu Gly Thr Phe 
    50                  55                  60                  
Asn Glu Leu Asp Gly Glu Met Ile Ala Phe Ser Ser Gln Val Tyr Gln 
65                  70                  75                  80  
Leu Arg Ala Asp Gly Ser Ala Arg Ala Ala Lys Pro Glu Gln Lys Thr 
                85                  90                  95      
Pro Phe Ala Val Met Thr Trp Phe Gln Pro Gln Tyr Arg Lys Thr Phe 
            100                 105                 110         
Asp Ala Pro Val Ser Arg Gln Gln Ile His Asp Val Ile Asp Gln Gln 
        115                 120                 125             
Ile Pro Ser Asp Asn Leu Phe Cys Ala Leu Arg Ile Asp Gly Asn Phe 
    130                 135                 140                 
Arg His Ala His Thr Arg Thr Val Pro Arg Gln Thr Pro Pro Tyr Arg 
145                 150                 155                 160 
Ala Met Thr Asp Val Leu Asp Asp Gln Pro Val Phe Arg Phe Asn Gln 
                165                 170                 175     
Arg Glu Gly Val Leu Val Gly Phe Arg Thr Pro Gln His Met Gln Gly 
            180                 185                 190         
Ile Asn Val Ala Gly Tyr His Glu His Phe Ile Thr Asp Asp Arg Gln 
        195                 200                 205             
Gly Gly Gly His Leu Leu Asp Tyr Gln Leu Glu Ser Gly Val Leu Thr 
    210                 215                 220                 
Phe Gly Glu Ile His Lys Leu Met Ile Asp Leu Pro Ala Asp Ser Ala 
225                 230                 235                 240 
Phe Leu Gln Ala Asn Leu His Pro Ser Asn Leu Asp Ala Ala Ile Arg 
                245                 250                 255     
Ser Val Glu Asn 
            260 

<210> 11
<211> 666
<212> DNA
<213> Lactococcus lactis

<400> 11
atgtcatcga gaatctttca acacaatacc ttcacaactt tgagtagcgg attttacaaa      60

ggcacaatca cgttgaaaga agccttagaa cacggatcag ttggcatagg tacattagat     120

actgcaaatg gtgaagttac catcatcaac ggtatagcct atcatggaga ttcggaaaac     180

catgtgagat tggtggaaga ggatgaaacg atgccttatg tcgctatggt tgaacatcaa     240

cccattgcaa agttcactga ttcctctgtg tcaaatagcg aagatttcct atccgcttta     300

accaaaaggt ttccaaccgt taatactgcc tacacaattg tcatgactgg tcagtttaag     360

gaagtaactg tctcttctaa accagcgaac aatactagac catatgacga aataatggct     420

gatcaaccgt actttacaaa ggagaacatt agtggtacaa tggttggtgt atgggctcct     480

aaacatctta ctgatctatt tgggttaggc tttcaccttc acttcgtttc tgacgataag     540

acgtttactg cacatgtaca gaatttcatt acagagaatc tggaaattga gatagggaaa     600

attaccaaga ttgaccaaga atttcctgat gatgacgaga acttcgacca acatttgttc     660

caataa                                                                666


<210> 12
<211> 221
<212> PRT
<213> Lactococcus lactis

<400> 12
Met Ser Ser Arg Ile Phe Gln His Asn Thr Phe Thr Thr Leu Ser Ser 
1               5                   10                  15      
Gly Phe Tyr Lys Gly Thr Ile Thr Leu Lys Glu Ala Leu Glu His Gly 
            20                  25                  30          
Ser Val Gly Ile Gly Thr Leu Asp Thr Ala Asn Gly Glu Val Thr Ile 
        35                  40                  45              
Ile Asn Gly Ile Ala Tyr His Gly Asp Ser Glu Asn His Val Arg Leu 
    50                  55                  60                  
Val Glu Glu Asp Glu Thr Met Pro Tyr Val Ala Met Val Glu His Gln 
65                  70                  75                  80  
Pro Ile Ala Lys Phe Thr Asp Ser Ser Val Ser Asn Ser Glu Asp Phe 
                85                  90                  95      
Leu Ser Ala Leu Thr Lys Arg Phe Pro Thr Val Asn Thr Ala Tyr Thr 
            100                 105                 110         
Ile Val Met Thr Gly Gln Phe Lys Glu Val Thr Val Ser Ser Lys Pro 
        115                 120                 125             
Ala Asn Asn Thr Arg Pro Tyr Asp Glu Ile Met Ala Asp Gln Pro Tyr 
    130                 135                 140                 
Phe Thr Lys Glu Asn Ile Ser Gly Thr Met Val Gly Val Trp Ala Pro 
145                 150                 155                 160 
Lys His Leu Thr Asp Leu Phe Gly Leu Gly Phe His Leu His Phe Val 
                165                 170                 175     
Ser Asp Asp Lys Thr Phe Thr Ala His Val Gln Asn Phe Ile Thr Glu 
            180                 185                 190         
Asn Leu Glu Ile Glu Ile Gly Lys Ile Thr Lys Ile Asp Gln Glu Phe 
        195                 200                 205             
Pro Asp Asp Asp Glu Asn Phe Asp Gln His Leu Phe Gln 
    210                 215                 220     

<210> 13
<211> 1341
<212> DNA
<213> Lactococcus lactis

<400> 13
atgggtattg tcgtaatagg tactaaccat gccggaatag ctacagcaaa taccttaatc      60

gaccaatatc caggacatga aattgttatg attgacagaa actcgaatat gagttatctt     120

ggctgtggta cagcgatttg ggttgggaga caaatcgaga aacctgatga acttttctat     180

gcaaaagcag aagatttcga aaagaagggt gttaaaatcc tgaccgagac tgaagtgtca     240

gaaatcgact ttaccaacaa aatgatatat gccaaaagca agactgggga gaaaatcacg     300

gaatcttatg ataagctagt attggcaaca ggaagcagac caatcatacc caatttgcct     360

ggtaaagatc ttaaaggaat tcatttctta aagttattcc aggaaggtca agccattgac     420

gaagaattcg caaagaatga cgtgaaaaga atcgcggtaa ttggtgctgg ttatattgga     480

acagagatag ctgaagcagc taaacgtaga gggaaagaag tgttgttgtt tgatgctgaa     540

agtacctcat tagcgtcata ctacgacgaa gaatttgcca aaggcatgga tgaaaatttg     600

gcacaacacg ggattgagtt gcactttggt gaacttgccc aagagttcaa ggcaaatgaa     660

gaaggtcatg tctcccagat tgttacaaac aaatccactt atgatgtgga tctggtcatc     720

aattgcatag gatttactgc caattcagcc ttagctggtg agcatctaga aacgtttaag     780

aacggtgcca taaaggttaa taagcatcaa caatctagtg atccagacgt gtatgcagtt     840

ggtgatgttg caactatcta ctctaacgct ttgcaagact ttacttacat cgctttagct     900

agcaatgctg ttagatcagg cattgttgct ggacacaata ttggcggtaa atccatagaa     960

tctgtcggtg ttcagggtag taacggcatt tctatattcg gatacaatat gacaagtact    1020

ggtttatcag taaaagctgc taagaagatt ggtctagaag tctccttttc tgattttgaa    1080

gataagcaaa aggcttggtt tctgcatgag aacaatgatt cggtcaaaat aaggatcgta    1140

tacgaaacaa aatccaggag aataattggc gcacaattgg catcgaaatc agagattata    1200

gcgggcaaca ttaacatgtt ctctttagcc attcaggaaa agaaaacgat tgatgagtta    1260

gccctattgg atttgttctt tctgcctcac tttaactctc cgtacaatta tatgaccgta    1320

gctgcgttga atgctaaata a                                              1341


<210> 14
<211> 446
<212> PRT
<213> Lactococcus lactis

<400> 14
Met Gly Ile Val Val Ile Gly Thr Asn His Ala Gly Ile Ala Thr Ala 
1               5                   10                  15      
Asn Thr Leu Ile Asp Gln Tyr Pro Gly His Glu Ile Val Met Ile Asp 
            20                  25                  30          
Arg Asn Ser Asn Met Ser Tyr Leu Gly Cys Gly Thr Ala Ile Trp Val 
        35                  40                  45              
Gly Arg Gln Ile Glu Lys Pro Asp Glu Leu Phe Tyr Ala Lys Ala Glu 
    50                  55                  60                  
Asp Phe Glu Lys Lys Gly Val Lys Ile Leu Thr Glu Thr Glu Val Ser 
65                  70                  75                  80  
Glu Ile Asp Phe Thr Asn Lys Met Ile Tyr Ala Lys Ser Lys Thr Gly 
                85                  90                  95      
Glu Lys Ile Thr Glu Ser Tyr Asp Lys Leu Val Leu Ala Thr Gly Ser 
            100                 105                 110         
Arg Pro Ile Ile Pro Asn Leu Pro Gly Lys Asp Leu Lys Gly Ile His 
        115                 120                 125             
Phe Leu Lys Leu Phe Gln Glu Gly Gln Ala Ile Asp Glu Glu Phe Ala 
    130                 135                 140                 
Lys Asn Asp Val Lys Arg Ile Ala Val Ile Gly Ala Gly Tyr Ile Gly 
145                 150                 155                 160 
Thr Glu Ile Ala Glu Ala Ala Lys Arg Arg Gly Lys Glu Val Leu Leu 
                165                 170                 175     
Phe Asp Ala Glu Ser Thr Ser Leu Ala Ser Tyr Tyr Asp Glu Glu Phe 
            180                 185                 190         
Ala Lys Gly Met Asp Glu Asn Leu Ala Gln His Gly Ile Glu Leu His 
        195                 200                 205             
Phe Gly Glu Leu Ala Gln Glu Phe Lys Ala Asn Glu Glu Gly His Val 
    210                 215                 220                 
Ser Gln Ile Val Thr Asn Lys Ser Thr Tyr Asp Val Asp Leu Val Ile 
225                 230                 235                 240 
Asn Cys Ile Gly Phe Thr Ala Asn Ser Ala Leu Ala Gly Glu His Leu 
                245                 250                 255     
Glu Thr Phe Lys Asn Gly Ala Ile Lys Val Asn Lys His Gln Gln Ser 
            260                 265                 270         
Ser Asp Pro Asp Val Tyr Ala Val Gly Asp Val Ala Thr Ile Tyr Ser 
        275                 280                 285             
Asn Ala Leu Gln Asp Phe Thr Tyr Ile Ala Leu Ala Ser Asn Ala Val 
    290                 295                 300                 
Arg Ser Gly Ile Val Ala Gly His Asn Ile Gly Gly Lys Ser Ile Glu 
305                 310                 315                 320 
Ser Val Gly Val Gln Gly Ser Asn Gly Ile Ser Ile Phe Gly Tyr Asn 
                325                 330                 335     
Met Thr Ser Thr Gly Leu Ser Val Lys Ala Ala Lys Lys Ile Gly Leu 
            340                 345                 350         
Glu Val Ser Phe Ser Asp Phe Glu Asp Lys Gln Lys Ala Trp Phe Leu 
        355                 360                 365             
His Glu Asn Asn Asp Ser Val Lys Ile Arg Ile Val Tyr Glu Thr Lys 
    370                 375                 380                 
Ser Arg Arg Ile Ile Gly Ala Gln Leu Ala Ser Lys Ser Glu Ile Ile 
385                 390                 395                 400 
Ala Gly Asn Ile Asn Met Phe Ser Leu Ala Ile Gln Glu Lys Lys Thr 
                405                 410                 415     
Ile Asp Glu Leu Ala Leu Leu Asp Leu Phe Phe Leu Pro His Phe Asn 
            420                 425                 430         
Ser Pro Tyr Asn Tyr Met Thr Val Ala Ala Leu Asn Ala Lys 
        435                 440                 445     

<210> 15
<211> 1380
<212> DNA
<213> Streptococcus pneumoniae

<400> 15
atgtctaaga tagtggtagt tggtgctaac catgcaggaa ctgcttgcat caatacgatg      60

ttggataatt tcggcaatga aaatgagata gtggtgtttg atcagaattc caacatcagc     120

tttctaggtt gtggtatggc gttatggatt ggggagcaaa tagatggtgc tgaagggttg     180

ttttactcag acaaagagaa attggaagcc aaaggtgcca aagtctacat gaattcgcca     240

gtcctgagta tagactatga caacaaagtg gtaactgcag aagtagaagg caaagagcac     300

aaagaatcct atgagaaact gatctttgct actggttcaa caccgatttt accacctatt     360

gaaggagtcg agatcgttaa aggtaataga gaatttaagg ccacacttga aaacgtacaa     420

tttgttaagt tgtatcagaa tgctgaagaa gtcatcaaca agctttcaga taaaagccag     480

catttagata ggattgctgt tgttggaggt ggatacattg gtgttgaatt ggctgaagcc     540

tttgaaagac taggaaaaga agttgtgtta gttgacattg tggacactgt cttaaacggg     600

tattatgaca aagatttcac ccaaatgatg gccaagaatc ttgaggatca caacattaga     660

cttgctttag gccaaacagt gaaggctatt gaaggcgatg gtaaggtaga aaggttgatt     720

acagacaagg agtctttcga tgttgacatg gtcattttag cagtaggatt tagaccaaac     780

actgctttgg cagatgggaa aattgaattg tttagaaatg gtgcttttct ggtggataag     840

aaacaagaaa cttcaatacc cgatgtttat gcagttggtg attgtgcaac agtctatgat     900

aatgccagaa aggatacttc ctacatagca ttggcatcta atgcagttag aacgggcatt     960

gttggtgctt ataatgcctg tggtcatgaa ttggagggca ttggtgtcca aggttctaat    1020

ggtatatcga tttatggcct tcatatggtt agtaccggat tgactctgga gaaggccaaa    1080

gctgctggat acaatgcgac agaaacaggt ttcaacgatt tacagaagcc agagtttatg    1140

aaacacgaca accatgaagt agcgatcaaa atcgtatttg acaaggattc tcgtgaaatt    1200

ctaggggcac aaatggtttc acacgatata gcgataagta tgggcatcca tatgttctct    1260

ctagcgattc aagaacatgt taccatagat aaattagcat taaccgatct attcttcttg    1320

cctcatttca acaaacctta caattacatc acgatggcag ctttgaccgc cgaaaagtaa    1380


<210> 16
<211> 459
<212> PRT
<213> Streptococcus pneumoniae

<400> 16
Met Ser Lys Ile Val Val Val Gly Ala Asn His Ala Gly Thr Ala Cys 
1               5                   10                  15      
Ile Asn Thr Met Leu Asp Asn Phe Gly Asn Glu Asn Glu Ile Val Val 
            20                  25                  30          
Phe Asp Gln Asn Ser Asn Ile Ser Phe Leu Gly Cys Gly Met Ala Leu 
        35                  40                  45              
Trp Ile Gly Glu Gln Ile Asp Gly Ala Glu Gly Leu Phe Tyr Ser Asp 
    50                  55                  60                  
Lys Glu Lys Leu Glu Ala Lys Gly Ala Lys Val Tyr Met Asn Ser Pro 
65                  70                  75                  80  
Val Leu Ser Ile Asp Tyr Asp Asn Lys Val Val Thr Ala Glu Val Glu 
                85                  90                  95      
Gly Lys Glu His Lys Glu Ser Tyr Glu Lys Leu Ile Phe Ala Thr Gly 
            100                 105                 110         
Ser Thr Pro Ile Leu Pro Pro Ile Glu Gly Val Glu Ile Val Lys Gly 
        115                 120                 125             
Asn Arg Glu Phe Lys Ala Thr Leu Glu Asn Val Gln Phe Val Lys Leu 
    130                 135                 140                 
Tyr Gln Asn Ala Glu Glu Val Ile Asn Lys Leu Ser Asp Lys Ser Gln 
145                 150                 155                 160 
His Leu Asp Arg Ile Ala Val Val Gly Gly Gly Tyr Ile Gly Val Glu 
                165                 170                 175     
Leu Ala Glu Ala Phe Glu Arg Leu Gly Lys Glu Val Val Leu Val Asp 
            180                 185                 190         
Ile Val Asp Thr Val Leu Asn Gly Tyr Tyr Asp Lys Asp Phe Thr Gln 
        195                 200                 205             
Met Met Ala Lys Asn Leu Glu Asp His Asn Ile Arg Leu Ala Leu Gly 
    210                 215                 220                 
Gln Thr Val Lys Ala Ile Glu Gly Asp Gly Lys Val Glu Arg Leu Ile 
225                 230                 235                 240 
Thr Asp Lys Glu Ser Phe Asp Val Asp Met Val Ile Leu Ala Val Gly 
                245                 250                 255     
Phe Arg Pro Asn Thr Ala Leu Ala Asp Gly Lys Ile Glu Leu Phe Arg 
            260                 265                 270         
Asn Gly Ala Phe Leu Val Asp Lys Lys Gln Glu Thr Ser Ile Pro Asp 
        275                 280                 285             
Val Tyr Ala Val Gly Asp Cys Ala Thr Val Tyr Asp Asn Ala Arg Lys 
    290                 295                 300                 
Asp Thr Ser Tyr Ile Ala Leu Ala Ser Asn Ala Val Arg Thr Gly Ile 
305                 310                 315                 320 
Val Gly Ala Tyr Asn Ala Cys Gly His Glu Leu Glu Gly Ile Gly Val 
                325                 330                 335     
Gln Gly Ser Asn Gly Ile Ser Ile Tyr Gly Leu His Met Val Ser Thr 
            340                 345                 350         
Gly Leu Thr Leu Glu Lys Ala Lys Ala Ala Gly Tyr Asn Ala Thr Glu 
        355                 360                 365             
Thr Gly Phe Asn Asp Leu Gln Lys Pro Glu Phe Met Lys His Asp Asn 
    370                 375                 380                 
His Glu Val Ala Ile Lys Ile Val Phe Asp Lys Asp Ser Arg Glu Ile 
385                 390                 395                 400 
Leu Gly Ala Gln Met Val Ser His Asp Ile Ala Ile Ser Met Gly Ile 
                405                 410                 415     
His Met Phe Ser Leu Ala Ile Gln Glu His Val Thr Ile Asp Lys Leu 
            420                 425                 430         
Ala Leu Thr Asp Leu Phe Phe Leu Pro His Phe Asn Lys Pro Tyr Asn 
        435                 440                 445             
Tyr Ile Thr Met Ala Ala Leu Thr Ala Glu Lys 
    450                 455                 

<210> 17
<211> 1341
<212> DNA
<213> Enterococcus faecalis

<400> 17
atgtctgtgg ttgtcgtagg ctgtacacat gctggtacta gtgcagtgaa atctatccta      60

gctaatcatc ccgaagctga agtcactgtt tatgaacgta atgacaacat atccttcttg     120

tcttgtggaa ttgcacttta tgttggaggt gtagttaaga atgctgccga cttattttac     180

agcaatcctg aggaattagc cagtttagga gccactgtga aaatggaaca caacgtagaa     240

gagatcaatg tcgatgataa gacagttacg gcaaagaatc tacaaacagg tgcaacagaa     300

accgtatcct acgataagtt ggtcatgact actggaagtt ggcctataat tccaccaata     360

cccggaattg atgctgagaa cattctactt tgcaagaatt attctcaagc gaatgtcatt     420

atcgaaaagg ccaaagatgc gaaaagagtc gttgtcgttg gtggtggcta tattggtata     480

gagttagttg aagcttttgt tgaaagcggt aaacaggtga ccctagttga tggtctagac     540

aggattttga acaagtattt ggacaaaccg tttactgatg ttttagaaaa ggagttagtt     600

gatagaggtg tgaacttagc cttaggtgaa aatgtccaac agtttgtagc tgatgaacag     660

ggaaaagttg caaaagttat cactccatct caagaattcg aagcagacat ggtcataatg     720

tgtgttggct ttagaccaaa taccgaactt ttgaaagaca aagttgatat gttgcctaac     780

ggtgcaattg aggttaacga gtatatgcaa acgtccaatc cagatatctt tgctgctggt     840

gattcagccg tagtgcatta caacccatcg caaacgaaga attatattcc cttagcgact     900

aatgcagtaa gacagggtat gttggtgggg agaaacttga cagaacagaa acttgcctat     960

agaggcaccc aaggtacgtc tggcttgtac ttgttcggtt ggaaaattgg ctcaacagga    1020

gtaaccaaag aatcggcaaa attgaatggg ttagatgttg aagctacagt ctttgaggat    1080

aactatagac ctgaattcat gccaacaacc gaaaaggtgc tgatggagct ggtgtacgaa    1140

aaggggactc aaaggatagt aggtgggcaa ttgatgtcca aatacgatat cactcaatca    1200

gcgaatacac tttcattggc tgtacagaac aaaatgaccg ttgaagatct ggctatttca    1260

gacttcttct ttcaaccgca ctttgaccgt ccttggaatt acttaaattt gctagcccaa    1320

gcagctctgg agaacatgta a                                              1341


<210> 18
<211> 446
<212> PRT
<213> Enterococcus faecalis

<400> 18
Met Ser Val Val Val Val Gly Cys Thr His Ala Gly Thr Ser Ala Val 
1               5                   10                  15      
Lys Ser Ile Leu Ala Asn His Pro Glu Ala Glu Val Thr Val Tyr Glu 
            20                  25                  30          
Arg Asn Asp Asn Ile Ser Phe Leu Ser Cys Gly Ile Ala Leu Tyr Val 
        35                  40                  45              
Gly Gly Val Val Lys Asn Ala Ala Asp Leu Phe Tyr Ser Asn Pro Glu 
    50                  55                  60                  
Glu Leu Ala Ser Leu Gly Ala Thr Val Lys Met Glu His Asn Val Glu 
65                  70                  75                  80  
Glu Ile Asn Val Asp Asp Lys Thr Val Thr Ala Lys Asn Leu Gln Thr 
                85                  90                  95      
Gly Ala Thr Glu Thr Val Ser Tyr Asp Lys Leu Val Met Thr Thr Gly 
            100                 105                 110         
Ser Trp Pro Ile Ile Pro Pro Ile Pro Gly Ile Asp Ala Glu Asn Ile 
        115                 120                 125             
Leu Leu Cys Lys Asn Tyr Ser Gln Ala Asn Val Ile Ile Glu Lys Ala 
    130                 135                 140                 
Lys Asp Ala Lys Arg Val Val Val Val Gly Gly Gly Tyr Ile Gly Ile 
145                 150                 155                 160 
Glu Leu Val Glu Ala Phe Val Glu Ser Gly Lys Gln Val Thr Leu Val 
                165                 170                 175     
Asp Gly Leu Asp Arg Ile Leu Asn Lys Tyr Leu Asp Lys Pro Phe Thr 
            180                 185                 190         
Asp Val Leu Glu Lys Glu Leu Val Asp Arg Gly Val Asn Leu Ala Leu 
        195                 200                 205             
Gly Glu Asn Val Gln Gln Phe Val Ala Asp Glu Gln Gly Lys Val Ala 
    210                 215                 220                 
Lys Val Ile Thr Pro Ser Gln Glu Phe Glu Ala Asp Met Val Ile Met 
225                 230                 235                 240 
Cys Val Gly Phe Arg Pro Asn Thr Glu Leu Leu Lys Asp Lys Val Asp 
                245                 250                 255     
Met Leu Pro Asn Gly Ala Ile Glu Val Asn Glu Tyr Met Gln Thr Ser 
            260                 265                 270         
Asn Pro Asp Ile Phe Ala Ala Gly Asp Ser Ala Val Val His Tyr Asn 
        275                 280                 285             
Pro Ser Gln Thr Lys Asn Tyr Ile Pro Leu Ala Thr Asn Ala Val Arg 
    290                 295                 300                 
Gln Gly Met Leu Val Gly Arg Asn Leu Thr Glu Gln Lys Leu Ala Tyr 
305                 310                 315                 320 
Arg Gly Thr Gln Gly Thr Ser Gly Leu Tyr Leu Phe Gly Trp Lys Ile 
                325                 330                 335     
Gly Ser Thr Gly Val Thr Lys Glu Ser Ala Lys Leu Asn Gly Leu Asp 
            340                 345                 350         
Val Glu Ala Thr Val Phe Glu Asp Asn Tyr Arg Pro Glu Phe Met Pro 
        355                 360                 365             
Thr Thr Glu Lys Val Leu Met Glu Leu Val Tyr Glu Lys Gly Thr Gln 
    370                 375                 380                 
Arg Ile Val Gly Gly Gln Leu Met Ser Lys Tyr Asp Ile Thr Gln Ser 
385                 390                 395                 400 
Ala Asn Thr Leu Ser Leu Ala Val Gln Asn Lys Met Thr Val Glu Asp 
                405                 410                 415     
Leu Ala Ile Ser Asp Phe Phe Phe Gln Pro His Phe Asp Arg Pro Trp 
            420                 425                 430         
Asn Tyr Leu Asn Leu Leu Ala Gln Ala Ala Leu Glu Asn Met 
        435                 440                 445     

<210> 19
<211> 1356
<212> DNA
<213> Lactobacillus brevis

<400> 19
atgtctaagg ttaccgtggt aggttgtaca catgccggta cttttgcaat caaacagatt      60

ttggcagaac atcctgatgc agaagtaaca gtctatgaga gaaatgacgt gattagcttc     120

ttgtcgtgtg gcatagcgtt gtacttgggt gggaaagttg ctgaccctca agggcttttc     180

tactcatcac cagaagagtt acaaaagctt ggggcgaatg tccaaatgaa ccacaacgtt     240

ttagcgatag atccagatca aaagactgtt actgttgaag atctaacgag tcatgctcag     300

acaacagaat cctatgacaa gttagtcatg acttcaggtt cttggccgat agttcccaaa     360

ataccaggta ttgactccga tagagtcaag ctgtgcaaga attgggctca tgcacaagct     420

ttgattgaag atgctaaaga agcgaaaaga attactgtca ttggcgctgg ttatatcggt     480

gccgaattgg ccgaagcgta ttctactaca ggtcacgacg taacgttgat agacgcaatg     540

gatagagtaa tgcccaaata ctttgatgca gattttaccg atgtcattga gcaagattat     600

cgtgatcatg gagtgcaatt agccttgagt gaaactgttg aatcgtttac agacagtgct     660

acaggattga ccataaagac tgacaagaat agttacgaaa cagatcttgc catcttatgc     720

attggcttta gaccaaatac ggatctgctg aaaggaaaag ttgatatggc accaaatggt     780

gctattatta ccgatgacta tatgcgttcc tctaatccgg acatatttgc tgcaggagac     840

tctgctgcag ttcactataa ccctacacac cagaatgcat atatcccact agccacaaat     900

gctgtgagac aaggtatatt agtaggcaag aatttggtca aaccgaccgt taaatacatg     960

ggtacgcaaa gctcttcagg tcttgccctg tacgatagga ctattgtttc gaccggctta    1020

acgctagcag cagctaaaca acagggtgtt aatgctgaac aggtgatcgt tgaggacaat    1080

tatagacctg agtttatgcc ttcaactgaa cccgtgctaa tgagcttagt ctttgatcca    1140

gatactcata ggatcttagg aggagctttg atgtccaaat acgatgtatc ccagtctgca    1200

aacaccttgt ctgtgtgtat ccaaaacgag aatactattg atgacttagc catggttgat    1260

atgcttttcc aacctaactt cgatagacca ttcaactatc taaacatttt ggctcaagct    1320

gctcaagcca aagtagctca atcagtaaac gcctag                              1356


<210> 20
<211> 451
<212> PRT
<213> Lactobacillus brevis

<400> 20
Met Ser Lys Val Thr Val Val Gly Cys Thr His Ala Gly Thr Phe Ala 
1               5                   10                  15      
Ile Lys Gln Ile Leu Ala Glu His Pro Asp Ala Glu Val Thr Val Tyr 
            20                  25                  30          
Glu Arg Asn Asp Val Ile Ser Phe Leu Ser Cys Gly Ile Ala Leu Tyr 
        35                  40                  45              
Leu Gly Gly Lys Val Ala Asp Pro Gln Gly Leu Phe Tyr Ser Ser Pro 
    50                  55                  60                  
Glu Glu Leu Gln Lys Leu Gly Ala Asn Val Gln Met Asn His Asn Val 
65                  70                  75                  80  
Leu Ala Ile Asp Pro Asp Gln Lys Thr Val Thr Val Glu Asp Leu Thr 
                85                  90                  95      
Ser His Ala Gln Thr Thr Glu Ser Tyr Asp Lys Leu Val Met Thr Ser 
            100                 105                 110         
Gly Ser Trp Pro Ile Val Pro Lys Ile Pro Gly Ile Asp Ser Asp Arg 
        115                 120                 125             
Val Lys Leu Cys Lys Asn Trp Ala His Ala Gln Ala Leu Ile Glu Asp 
    130                 135                 140                 
Ala Lys Glu Ala Lys Arg Ile Thr Val Ile Gly Ala Gly Tyr Ile Gly 
145                 150                 155                 160 
Ala Glu Leu Ala Glu Ala Tyr Ser Thr Thr Gly His Asp Val Thr Leu 
                165                 170                 175     
Ile Asp Ala Met Asp Arg Val Met Pro Lys Tyr Phe Asp Ala Asp Phe 
            180                 185                 190         
Thr Asp Val Ile Glu Gln Asp Tyr Arg Asp His Gly Val Gln Leu Ala 
        195                 200                 205             
Leu Ser Glu Thr Val Glu Ser Phe Thr Asp Ser Ala Thr Gly Leu Thr 
    210                 215                 220                 
Ile Lys Thr Asp Lys Asn Ser Tyr Glu Thr Asp Leu Ala Ile Leu Cys 
225                 230                 235                 240 
Ile Gly Phe Arg Pro Asn Thr Asp Leu Leu Lys Gly Lys Val Asp Met 
                245                 250                 255     
Ala Pro Asn Gly Ala Ile Ile Thr Asp Asp Tyr Met Arg Ser Ser Asn 
            260                 265                 270         
Pro Asp Ile Phe Ala Ala Gly Asp Ser Ala Ala Val His Tyr Asn Pro 
        275                 280                 285             
Thr His Gln Asn Ala Tyr Ile Pro Leu Ala Thr Asn Ala Val Arg Gln 
    290                 295                 300                 
Gly Ile Leu Val Gly Lys Asn Leu Val Lys Pro Thr Val Lys Tyr Met 
305                 310                 315                 320 
Gly Thr Gln Ser Ser Ser Gly Leu Ala Leu Tyr Asp Arg Thr Ile Val 
                325                 330                 335     
Ser Thr Gly Leu Thr Leu Ala Ala Ala Lys Gln Gln Gly Val Asn Ala 
            340                 345                 350         
Glu Gln Val Ile Val Glu Asp Asn Tyr Arg Pro Glu Phe Met Pro Ser 
        355                 360                 365             
Thr Glu Pro Val Leu Met Ser Leu Val Phe Asp Pro Asp Thr His Arg 
    370                 375                 380                 
Ile Leu Gly Gly Ala Leu Met Ser Lys Tyr Asp Val Ser Gln Ser Ala 
385                 390                 395                 400 
Asn Thr Leu Ser Val Cys Ile Gln Asn Glu Asn Thr Ile Asp Asp Leu 
                405                 410                 415     
Ala Met Val Asp Met Leu Phe Gln Pro Asn Phe Asp Arg Pro Phe Asn 
            420                 425                 430         
Tyr Leu Asn Ile Leu Ala Gln Ala Ala Gln Ala Lys Val Ala Gln Ser 
        435                 440                 445             
Val Asn Ala 
    450     

<210> 21
<211> 550
<212> DNA
<213> Artificial Sequence

<220> 
<223> pENO2

<400> 21
cgctcagcat ctgcttcttc ccaaagatga acgcggcgtt atgtcactaa cgacgtgcac      60

caacttgcgg aaagtggaat cccgttccaa aactggcatc cactaattga tacatctaca     120

caccgcacgc cttttttctg aagcccactt tcgtggactt tgccatatgc aaaattcatg     180

aagtgtgata ccaagtcagc atacacctca ctagggtagt ttctttggtt gtattgatca     240

tttggttcat cgtggttcat taattttttt tctccattgc tttctggctt tgatcttact     300

atcatttgga tttttgtcga aggttgtaga attgtatgtg acaagtggca ccaagcatat     360

ataaaaaaaa aaagcattat cttcctacca gagttgattg ttaaaaacgt atttatagca     420

aacgcaattg taattaattc ttattttgta tcttttcttc ccttgtctca atcttttatt     480

tttattttat ttttcttttc ttagtttctt tcataacacc aagcaactaa tactataaca     540

tacaataata                                                            550


<210> 22
<211> 419
<212> DNA
<213> Artificial Sequence

<220> 
<223> pTEF2.Kl

<400> 22
ctctctcgca ataacaatga acactgggtc aatcatagcc tacacaggtg aacagagtag      60

cgtttataca gggtttatac ggtgattcct acggcaaaaa tttttcattt ctaaaaaaaa     120

aaagaaaaat ttttctttcc aacgctagaa ggaaaagaaa aatctaatta aattgatttg     180

gtgattttct gagagttccc tttttcatat atcgaatttt gaatataaaa ggagatcgaa     240

aaaatttttc tattcaatct gttttctggt tttatttgat agtttttttg tgtattatta     300

ttatggatta gtactggttt atatgggttt ttctgtataa cttcttttta ttttagtttg     360

tttaatctta ttttgagtta cattatagtt ccctaactgc aagagaagta acattaaaa      419


<210> 23
<211> 598
<212> DNA
<213> Artificial Sequence

<220> 
<223> pTEF3

<400> 23
ggctgataat agcgtataaa caatgcatac tttgtacgtt caaaatacaa tgcagtagat      60

atatttatgc atattacata taatacatat cacataggaa gcaacaggcg cgttggactt     120

ttaattttcg aggaccgcga atccttacat cacacccaat cccccacaag tgatccccca     180

cacaccatag cttcaaaatg tttctactcc ttttttactc ttccagattt tctcggactc     240

cgcgcatcgc cgtaccactt caaaacaccc aagcacagca tactaaattt cccctctttc     300

ttcctctagg gtgtcgttaa ttacccgtac taaaggtttg gaaaagaaaa aagagaccgc     360

ctcgtttctt tttcttcgtc gaaaaaggca ataaaaattt ttatcacgtt tctttttctt     420

gaaaattttt ttttttgatt tttttctctt tcgatgacct cccattgata tttaagttaa     480

taaacggtct tcaatttctc aagtttcagt ttcatttttc ttgttctatt acaacttttt     540

ttacttcttg ctcattagaa agaaagcata gcaatctaat ctaagtttta attacaaa       598


<210> 24
<211> 700
<212> DNA
<213> Artificial Sequence

<220> 
<223> pADH1

<400> 24
gggtgtacaa tatggacttc ctcttttctg gcaaccaaac ccatacatcg ggattcctat      60

aataccttcg ttggtctccc taacatgtag gtggcggagg ggagatatac aatagaacag     120

ataccagaca agacataatg ggctaaacaa gactacacca attacactgc ctcattgatg     180

gtggtacata acgaactaat actgtagccc tagacttgat agccatcatc atatcgaagt     240

ttcactaccc tttttccatt tgccatctat tgaagtaata ataggcgcat gcaacttctt     300

ttcttttttt ttcttttctc tctcccccgt tgttgtctca ccatatccgc aatgacaaaa     360

aaatgatgga agacactaaa ggaaaaaatt aacgacaaag acagcaccaa cagatgtcgt     420

tgttccagag ctgatgaggg gtatctcgaa gcacacgaaa ctttttcctt ccttcattca     480

cgcacactac tctctaatga gcaacggtat acggccttcc ttccagttac ttgaatttga     540

aataaaaaaa agtttgctgt cttgctatca agtataaata gacctgcaat tattaatctt     600

ttgtttcctc gtcattgttc tcgttccctt tcttccttgt ttctttttct gcacaatatt     660

tcaagctata ccaagcatac aatcaactat ctcatataca                           700


<210> 25
<211> 549
<212> DNA
<213> Artificial Sequence

<220> 
<223> pGPM1

<400> 25
gccaaacttt tcggttaaca catgcagtga tgcacgcgcg atggtgctaa gttacatata      60

tatatatata tatatatata tatatatata gccatagtga tgtctaagta acctttatgg     120

tatatttctt aatgtggaaa gatactagcg cgcgcaccca cacacaagct tcgtcttttc     180

ttgaagaaaa gaggaagctc gctaaatggg attccacttt ccgttccctg ccagctgatg     240

gaaaaaggtt agtggaacga tgaagaataa aaagagagat ccactgaggt gaaatttcag     300

ctgacagcga gtttcatgat cgtgatgaac aatggtaacg agttgtggct gttgccaggg     360

agggtggttc tcaactttta atgtatggcc aaatcgctac ttgggtttgt tatataacaa     420

agaagaaata atgaactgat tctcttcctc cttcttgtcc tttcttaatt ctgttgtaat     480

taccttcctt tgtaattttt tttgtaatta ttcttcttaa taatccaaac aaacacacat     540

attacaata                                                             549


<210> 26
<211> 650
<212> DNA
<213> Artificial Sequence

<220> 
<223> pFBA1

<400> 26
acgcaagccc taagaaatga ataacaatac tgacagtact aaataattgc ctacttggct      60

tcacatacgt tgcatacgtc gatatagata ataatgataa tgacagcagg attatcgtaa     120

tacgtaatag ttgaaaatct caaaaatgtg tgggtcatta cgtaaataat gataggaatg     180

ggattcttct atttttcctt tttccattct agcagccgtc gggaaaacgt ggcatcctct     240

ctttcgggct caattggagt cacgctgccg tgagcatcct ctctttccat atctaacaac     300

tgagcacgta accaatggaa aagcatgagc ttagcgttgc tccaaaaaag tattggatgg     360

ttaataccat ttgtctgttc tcttctgact ttgactcctc aaaaaaaaaa aatctacaat     420

caacagatcg cttcaattac gccctcacaa aaactttttt ccttcttctt cgcccacgtt     480

aaattttatc cctcatgttg tctaacggat ttctgcactt gatttattat aaaaagacaa     540

agacataata cttctctatc aatttcagtt attgttcttc cttgcgttat tcttctgttc     600

ttctttttct tttgtcatat ataaccataa ccaagtaata catattcaaa                650


<210> 27
<211> 700
<212> DNA
<213> Artificial Sequence

<220> 
<223> pPDC1

<400> 27
ttatttacct atctctaaac ttcaacacct tatatcataa ctaatatttc ttgagataag      60

cacactgcac ccataccttc cttaaaaacg tagcttccag tttttggtgg ttccggcttc     120

cttcccgatt ccgcccgcta aacgcatatt tttgttgcct ggtggcattt gcaaaatgca     180

taacctatgc atttaaaaga ttatgtatgc tcttctgact tttcgtgtga tgaggctcgt     240

ggaaaaaatg aataatttat gaatttgaga acaattttgt gttgttacgg tattttacta     300

tggaataatc aatcaattga ggattttatg caaatatcgt ttgaatattt ttccgaccct     360

ttgagtactt ttcttcataa ttgcataata ttgtccgctg cccctttttc tgttagacgg     420

tgtcttgatc tacttgctat cgttcaacac caccttattt tctaactatt ttttttttag     480

ctcatttgaa tcagcttatg gtgatggcac atttttgcat aaacctagct gtcctcgttg     540

aacataggaa aaaaaaatat ataaacaagg ctctttcact ctccttgcaa tcagatttgg     600

gtttgttccc tttattttca tatttcttgt catattcctt tctcaattat tattttctac     660

tcataacctc acgcaaaata acacagtcaa atcaatcaaa                           700


<210> 28
<211> 700
<212> DNA
<213> Artificial Sequence

<220> 
<223> pPGK1

<400> 28
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaaaaaac ccagacacgc     240

tcgacttcct gtcttcctat tgattgcagc ttccaatttc gtcacacaac aaggtcctag     300

cgacggctca caggttttgt aacaagcaat cgaaggttct ggaatggcgg gaaagggttt     360

agtaccacat gctatgatgc ccactgtgat ctccagagca aagttcgttc gatcgtactg     420

ttactctctc tctttcaaac agaattgtcc gaatcgtgtg acaacaacag cctgttctca     480

cacactcttt tcttctaacc aagggggtgg tttagtttag tagaacctcg tgaaacttac     540

atttacatat atataaactt gcataaattg gtcaatgcaa gaaatacata tttggtcttt     600

tctaattcgt agtttttcaa gttcttagat gctttctttt tctctttttt acagatcatc     660

aaggaagtaa ttatctactt tttacaacaa atataaaaca                           700


<210> 29
<211> 535
<212> DNA
<213> Artificial Sequence

<220> 
<223> pRPLA1

<400> 29
tcaagttgga tactgatctg atctctccgc cctactacca gggaccctca tgattaccgc      60

tcgaatgcga cgtttcctgc ctcataaaac tggcttgaaa atatttattc gctgaacagt     120

agcctagctt ataaaaattt catttaatta atgtaatatg aaaactcaca tgccttctgt     180

ttctaaaatt gtcacagcaa gaaataacat taccatacgt gatcttatta aactctagta     240

tcttgtctaa tacttcattt aaaagaagcc ttaaccctgt agcctcatct atgtctgcta     300

catatcgtga ggtacgaata tcgtaagatg ataccacgca actttgtaat gatttttttt     360

ttttcatttt ttaaagaatg cctttacatg gtatttgaaa aaaatatctt tataaagttt     420

gcgatctctt ctgttctgaa taatttttag taaaagaaat caaaagaata aagaaatagt     480

ccgctttgtc caatacaaca gcttaaaccg attatctcta aaataacaag aagaa          535


<210> 30
<211> 383
<212> DNA
<213> Artificial Sequence

<220> 
<223> pTEF1

<400> 30
gtttagcttg cctcgtcccc gccgggtcac ccggccagcg acatggaggc ccagaatacc      60

ctccttgaca gtcttgacgt gcgcagctca ggggcatgat gtgactgtcg cccgtacatt     120

tagcccatac atccccatgt ataatcattt gcatccatac attttgatgg ccgcacggcg     180

cgaagcaaaa attacggctc ctcgctgcag acctgcgagc agggaaacgc tcccctcaca     240

gacgcgttga attgtcccca cgccgcgccc ctgtagagaa atataaaagg ttaggatttg     300

ccactgaggt tcttctttca tatacttcct tttaaaatct tgctacgata cagttctcac     360

atcacatccg aacataaaca acc                                             383


<210> 31
<211> 574
<212> DNA
<213> Artificial Sequence

<220> 
<223> pTDH3

<400> 31
ctgctgtaac ccgtacatgc ccaaaatagg gggcgggtta cacagaatat ataacatcgt      60

aggtgtctgg gtgaacagtt tattcctggc atccactaaa tataatggag cccgcttttt     120

aagctggcat ccagaaaaaa aaagaatccc agcaccaaaa tattgttttc ttcaccaacc     180

atcagttcat aggtccattc tcttagcgca actacagaga acaggggcac aaacaggcaa     240

aaaacgggca caacctcaat ggagtgatgc aacctgcctg gagtaaatga tgacacaagg     300

caattgaccc acgcatgtat ctatctcatt ttcttacacc ttctattacc ttctgctctc     360

tctgatttgg aaaaagctga aaaaaaaggt tgaaaccagt tccctgaaat tattccccta     420

cttgactaat aagtatataa agacggtagg tattgattgt aattctgtaa atctatttct     480

taaacttctt aaattctact tttatagtta gtcttttttt tagttttaaa acaccaagaa     540

cttagtttcg aataaacaca cataaacaaa caaa                                 574


<210> 32
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> tTHD2

<400> 32
atttaactcc ttaagttact ttaatgattt agtttttatt attaataatt catgctcatg     60

acatctcata tacacgttta taaaacttaa atagattgaa aatgtattaa agattcctca    120

gggattcgat ttttttggaa gtttttgttt ttttttcctt gagatgctgt agtatttggg    180

aacaattata caatcgaaag atatatgctt acattcgacc gttttagccg tgatcattat    240

cctatagtaa cataacctga agcataactg acactactat catcaatact tgtcacatga    300


<210> 33
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> tCYC1

<400> 33
acaggcccct tttcctttgt cgatatcatg taattagtta tgtcacgctt acattcacgc     60

cctcctccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc    120

cctatttatt ttttttaata gttatgttag tattaagaac gttatttata tttcaaattt    180

ttcttttttt tctgtacaaa cgcgtgtacg catgtaacat tatactgaaa accttgcttg    240

agaaggtttt gggacgctcg aaggctttaa tttgcaagct tcgcagttta cactctcatc    300


<210> 34
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> tTDH3

<400> 34
gtgaatttac tttaaatctt gcatttaaat aaattttctt tttatagctt tatgacttag     60

tttcaattta tatactattt taatgacatt ttcgattcat tgattgaaag ctttgtgttt    120

tttcttgatg cgctattgca ttgttcttgt ctttttcgcc acatgtaata tctgtagtag    180

atacctgata cattgtggat gctgagtgaa attttagtta ataatggagg cgctcttaat    240

aattttgggg atattggctt ttttttttaa agtttacaaa tgaatttttt ccgccaggat    300


<210> 35
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> tADH1

<400> 35
actagttcta gagcggccgc caccgcggtg ggcgaatttc ttatgattta tgatttttat      60

tattaaataa gttataaaaa aaataagtgt atacaaattt taaagtgact cttaggtttt     120

aaaacgaaaa ttcttattct tgagtaactc tttcctgtag gtcaggttgc tttctcaggt     180

atagcatgag gtcgctctta ttgaccacac ctctaccggc atgccgagca aatgcctgca     240

aatcgctccc catttcaccc aattgtagat atgctaactc cagcaatgag ttgatgaatc     300

tcggtgtgta ttttatgtcc tcagaggaca acacctgttg taatcgttct tcca           354


<210> 36
<211> 299
<212> DNA
<213> Artificial Sequence

<220> 
<223> tTPI1

<400> 36
gattaatata attatataaa aatattatct tcttttcttt atatctagtg ttatgtaaaa     60

taaattgatg actacggaaa gcttttttat attgtttctt tttcattctg agccacttaa    120

atttcgtgaa tgttcttgta agggacggta gatttacaag tgatacaaca aaaagcaagg    180

cgctttttct aataaaaaga agaaaagcat ttaacaattg aacacctcta tatcaacgaa    240

gaatattact ttgtctctaa atccttgtaa aatgtgtacg atctctatat gggttactc     299


<210> 37
<211> 299
<212> DNA
<213> Artificial Sequence

<220> 
<223> tMET25

<400> 37
gtgtgcgtaa tgagttgtaa aattatgtat aaacctactt tctctcacaa gtactatact     60

tttataaaac gaactttatt gaaatgaata tccttttttt cccttgttac atgtcgtgac    120

tcgtactttg aacctaaatt gttctaacat caaagaacag tgttaattcg cagtcgagaa    180

gaaaaatatg gtgaacaaga ctcatctact tcatgagact actttacgcc tcctataaag    240

ctgtcacact ggataaattt attgtaggac caagttacaa aagaggatga tggaggttt     299


<210> 38
<211> 305
<212> DNA
<213> Artificial Sequence

<220> 
<223> tENO2

<400> 38
ggatcctaaa gtgcttttaa ctaagaatta ttagtctttt ctgcttattt tttcatcata     60

gtttagaaca ctttatatta acgaatagtt tatgaatcta tttaggttta aaaattgata    120

cagttttata agttactttt tcaaagactc gtgctgtcta ttgcataatg cactggaagg    180

ggaaaaaaaa ggtgcacacg cgtggctttt tcttgaattt gcagtttgaa aaataactac    240

atggatgata agaaaacatg gagtacagtc actttgagaa ccttcaatca gctggtaacg    300

tcttc                                                                305


<210> 39
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> tMET3

<400> 39
tcgtcataaa atgctcccat ctcaaaagta gggcaaaatt catgatcgac cgcgcaaaat     60

aaatagattt gcaaataagt tttgtatgta catttattaa tatatataat atatcaaaag    120

aaaaaaatca aaaaaaaaaa aaaaaaaaaa ttgcactctt attcagtcat caattacaaa    180

acctagagat agcgatggtg catattcaat aaaaaactcc ttatactgtc gagaaagctt    240

attattggta cttctcgaag atactaaaaa aggttaattt ttggagacgg aggcaatagc    300


<210> 40
<211> 301
<212> DNA
<213> Artificial Sequence

<220> 
<223> tPGK1

<400> 40
attgaattga attgaaatcg atagatcaat ttttttcttt tctctttccc catcctttac     60

gctaaaataa tagtttattt tattttttga atatttttta tttatatacg tatatataga    120

ctattattta tcttttaatg attattaaga tttttattaa aaaaaaattc gctcctcttt    180

taatgccttt atgcagtttt tttttcccat tcgatatttc tatgttcggg ttcagcgtat    240

tttaagttta ataactcgaa aattctgcgt tcgttaaagc tttcgagaag gatattattt    300

a                                                                    301


<210> 41
<211> 700
<212> DNA
<213> Artificial Sequence

<220> 
<223> pPYK1

<400> 41
aaaaggaaag attattgaaa gagaaagaaa gaaaaaaaaa aaatgtacac ccagacatcg      60

ggcttccaca atttcggctc tattgttttc catctctcgc aacggcggga ttcctctatg     120

gcgtgtgatg tctgtatctg ttacttaatc cagaaactgg cacttgaccc aactctgcca     180

cgtgggtcgt tttgccatcg acagattggg agattttcat agtagaattc agcatgatag     240

ctacgtaaat gtgttccgca ccgtcacaaa gtgttttcta ctgttctttc ttctttcgtt     300

cattcagttg agttgagtga gtgctttgtt caatggatct tagctaaaat gcatattttt     360

tctcttggta aatgaatgct tgtgatgtct tccaagtgat ttcctttcct tcccatatga     420

tgctaggtac ctttagtgtc ttcctaaaaa aaaaaaaagg ctcgccatca aaacgatatt     480

cgttggcttt tttttctgaa ttataaatac tctttggtaa cttttcattt ccaagaacct     540

cttttttcca gttatatcat ggtccccttt caaagttatt ctctactctt tttcatattc     600

attctttttc atcctttggt tttttattct taacttgttt attattctct cttgtttcta     660

tttacaagac accaatcaaa acaaataaaa catcatcaca                           700


<210> 42
<211> 500
<212> DNA
<213> Artificial Sequence

<220> 
<223> pTPI1

<400> 42
atttaaactg tgaggacctt aatacattca gacacttctg cggtatcacc ctacttattc      60

ccttcgagat tatatctagg aacccatcag gttggtggaa gattacccgt tctaagactt     120

ttcagcttcc tctattgatg ttacacctgg acaccccttt tctggcatcc agtttttaat     180

cttcagtggc atgtgagatt ctccgaaatt aattaaagca atcacacaat tctctcggat     240

accacctcgg ttgaaactga caggtggttt gttacgcatg ctaatgcaaa ggagcctata     300

tacctttggc tcggctgctg taacagggaa tataaagggc agcataattt aggagtttag     360

tgaacttgca acatttacta ttttcccttc ttacgtaaat atttttcttt ttaattctaa     420

atcaatcttt ttcaattttt tgtttgtatt cttttcttgc ttaaatctat aactacaaaa     480

aacacataca taaactaaaa                                                 500


<210> 43
<211> 300
<212> DNA
<213> Artificial Sequence

<220> 
<223> tDIT1

<400> 43
taaagtaaga gcgctacatt ggtctacctt tttgttcttt tacttaaaca ttagttagtt     60

cgttttcttt ttctcatttt tttatgtttc ccccccaaag ttctgatttt ataatatttt    120

atttcacaca attccattta acagaggggg aatagattct ttagcttaga aaattagtga    180

tcaatatata tttgcctttc ttttcatctt ttcagtgata ttaatggttt cgagacactg    240

caatggccct agttgtctaa gaggatagat gttactgtca aagatgatat tttgaatttc    300


<210> 44
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> loxP

<400> 44
ataacttcgt ataatgtatg ctatacgaag tta                                  33


<210> 45
<211> 2085
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid HAA-1

<400> 45
atggtcttga taaatggcat aaagtatgcc tgtgagaggt gcataagagg ccatagagta      60

acaacatgca atcatacaga tcaaccgctt atgatgatca aacccaaagg tagaccttcc     120

actacatgcg actattgtaa acaacttcga aaaaacaaga atgcaaatcc tgaaggtgtt     180

tgcacgtgtg gccggctaga gaagaaaaaa ctggcacaga aagccaaaga agaagcaaga     240

gctaaagcca aagaaaaaca aagaaaacag tgtacctgcg ggactgatga ggtttgcaaa     300

tatcatgctc aaaagagaca tctaagaaag tccccttcaa gttctcaaaa gaaaggaaga     360

tccatttctc gttctcaacc aatgtttgaa agggtattgt cttctacttc acttgacagc     420

aatatgttat ccggccacgg agcactatca gatacctcta gcatactgac gagcacattt     480

ttagacagtg agccgggtgt tggtaaaatt tcaaaagatt accatcatgt cccttcattg     540

gcctccattt catccttaca atcctcgcaa tcgttagatc aaaatttcag tataccacaa     600

agcccgccgt tatcttcaat gtcatttaat tttctcacgg gaaatatcaa tgaaaccaac     660

caaaatcaca gtaatcatca gcattcaaaa tcaggcaata actggcaaga tagttcggta     720

agcttgccag cgaaagctga ttcacgtctt aacatgatgg ataaaaacaa ctctgtgggt     780

cttgacctat taggccattc aaaacgaata tcgccgatat caaactctcg tgtgggcgaa     840

gttagcgttc cgctagaaga atatattcct tctgacattg atggggttgg aagagttact     900

gataaaagct ctttggtcta cgattggcca tttgatgaaa gtattgagag aaatttcagt     960

acaaccgcaa ccgctgcaac tggtgaaagt aagttcgaca ttaacgacaa ctgtaataga    1020

attaatagca aaagttatag taagactaat agtatgaatg gaaacggtat gaacaatagc    1080

aataataata atatcaacag taatggcaac gacaagaaca ataacaactc ttctagacaa    1140

gaacatcaag gaaatggact atttgacatg tttacagatt catcgtcgat ttcaacgctt    1200

tcccgtgcaa acttattatt gcaagaaaaa attggttcgc aagaaaactc tgtcaaacaa    1260

gaaaactatt cgaaaaatcc tcaacttcgt catcaattaa cttccagaag tagatcattt    1320

attcatcatc cggcaaacga gtatttgaag aatacttttg gaaattcaca tagtaatgac    1380

atcggaaagg gagttgaagt gctatctttg acaccgagtt ttatggatat tcccgaaaaa    1440

gaaagagaaa cggaaagatc gccatcatcc aattacatta ctgacagacc tttcactcga    1500

aaacctagat cttctagcat tgacgtaaac cataggtatc cacctatggc accaacaacc    1560

gtagcgacat ctcccggtgc attgaacaat gccgtagcaa gcaatctcga cgatcaactg    1620

agtttaacat cactaaactc tcagccatca tcgatagcaa atatgatgat ggacccttca    1680

aacctagctg agcaaagttc tattcattca gttcctcagt caataaactc tccgagaatg    1740

cctaaaactg gaagtcgcca agacaagaac attcacacta agaaggaaga aagaaatccg    1800

ctaaataaca tacacgatct gtcacaattg gaaaatgtac cagacgagat gaaccaaatg    1860

ttctccccac cattaaaaag tatgaataga ccggatgcca taagggaaaa ttcatctagt    1920

agtaatttca taatccaagg aaatagcatg atctctacgc cttccggaag gaatgacctt    1980

ccagatacct ctccaatgag tagtattcaa acagcgtcac caccaagtca attactgacc    2040

gatcaaggat ttgcggattt ggataatttc atgtcttcgt tatga                    2085


<210> 46
<211> 694
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid HAA-1

<400> 46
Met Val Leu Ile Asn Gly Ile Lys Tyr Ala Cys Glu Arg Cys Ile Arg 
1               5                   10                  15      
Gly His Arg Val Thr Thr Cys Asn His Thr Asp Gln Pro Leu Met Met 
            20                  25                  30          
Ile Lys Pro Lys Gly Arg Pro Ser Thr Thr Cys Asp Tyr Cys Lys Gln 
        35                  40                  45              
Leu Arg Lys Asn Lys Asn Ala Asn Pro Glu Gly Val Cys Thr Cys Gly 
    50                  55                  60                  
Arg Leu Glu Lys Lys Lys Leu Ala Gln Lys Ala Lys Glu Glu Ala Arg 
65                  70                  75                  80  
Ala Lys Ala Lys Glu Lys Gln Arg Lys Gln Cys Thr Cys Gly Thr Asp 
                85                  90                  95      
Glu Val Cys Lys Tyr His Ala Gln Lys Arg His Leu Arg Lys Ser Pro 
            100                 105                 110         
Ser Ser Ser Gln Lys Lys Gly Arg Ser Ile Ser Arg Ser Gln Pro Met 
        115                 120                 125             
Phe Glu Arg Val Leu Ser Ser Thr Ser Leu Asp Ser Asn Met Leu Ser 
    130                 135                 140                 
Gly His Gly Ala Leu Ser Asp Thr Ser Ser Ile Leu Thr Ser Thr Phe 
145                 150                 155                 160 
Leu Asp Ser Glu Pro Gly Val Gly Lys Ile Ser Lys Asp Tyr His His 
                165                 170                 175     
Val Pro Ser Leu Ala Ser Ile Ser Ser Leu Gln Ser Ser Gln Ser Leu 
            180                 185                 190         
Asp Gln Asn Phe Ser Ile Pro Gln Ser Pro Pro Leu Ser Ser Met Ser 
        195                 200                 205             
Phe Asn Phe Leu Thr Gly Asn Ile Asn Glu Thr Asn Gln Asn His Ser 
    210                 215                 220                 
Asn His Gln His Ser Lys Ser Gly Asn Asn Trp Gln Asp Ser Ser Val 
225                 230                 235                 240 
Ser Leu Pro Ala Lys Ala Asp Ser Arg Leu Asn Met Met Asp Lys Asn 
                245                 250                 255     
Asn Ser Val Gly Leu Asp Leu Leu Gly His Ser Lys Arg Ile Ser Pro 
            260                 265                 270         
Ile Ser Asn Ser Arg Val Gly Glu Val Ser Val Pro Leu Glu Glu Tyr 
        275                 280                 285             
Ile Pro Ser Asp Ile Asp Gly Val Gly Arg Val Thr Asp Lys Ser Ser 
    290                 295                 300                 
Leu Val Tyr Asp Trp Pro Phe Asp Glu Ser Ile Glu Arg Asn Phe Ser 
305                 310                 315                 320 
Thr Thr Ala Thr Ala Ala Thr Gly Glu Ser Lys Phe Asp Ile Asn Asp 
                325                 330                 335     
Asn Cys Asn Arg Ile Asn Ser Lys Ser Tyr Ser Lys Thr Asn Ser Met 
            340                 345                 350         
Asn Gly Asn Gly Met Asn Asn Ser Asn Asn Asn Asn Ile Asn Ser Asn 
        355                 360                 365             
Gly Asn Asp Lys Asn Asn Asn Asn Ser Ser Arg Gln Glu His Gln Gly 
    370                 375                 380                 
Asn Gly Leu Phe Asp Met Phe Thr Asp Ser Ser Ser Ile Ser Thr Leu 
385                 390                 395                 400 
Ser Arg Ala Asn Leu Leu Leu Gln Glu Lys Ile Gly Ser Gln Glu Asn 
                405                 410                 415     
Ser Val Lys Gln Glu Asn Tyr Ser Lys Asn Pro Gln Leu Arg His Gln 
            420                 425                 430         
Leu Thr Ser Arg Ser Arg Ser Phe Ile His His Pro Ala Asn Glu Tyr 
        435                 440                 445             
Leu Lys Asn Thr Phe Gly Asn Ser His Ser Asn Asp Ile Gly Lys Gly 
    450                 455                 460                 
Val Glu Val Leu Ser Leu Thr Pro Ser Phe Met Asp Ile Pro Glu Lys 
465                 470                 475                 480 
Glu Arg Glu Thr Glu Arg Ser Pro Ser Ser Asn Tyr Ile Thr Asp Arg 
                485                 490                 495     
Pro Phe Thr Arg Lys Pro Arg Ser Ser Ser Ile Asp Val Asn His Arg 
            500                 505                 510         
Tyr Pro Pro Met Ala Pro Thr Thr Val Ala Thr Ser Pro Gly Ala Leu 
        515                 520                 525             
Asn Asn Ala Val Ala Ser Asn Leu Asp Asp Gln Leu Ser Leu Thr Ser 
    530                 535                 540                 
Leu Asn Ser Gln Pro Ser Ser Ile Ala Asn Met Met Met Asp Pro Ser 
545                 550                 555                 560 
Asn Leu Ala Glu Gln Ser Ser Ile His Ser Val Pro Gln Ser Ile Asn 
                565                 570                 575     
Ser Pro Arg Met Pro Lys Thr Gly Ser Arg Gln Asp Lys Asn Ile His 
            580                 585                 590         
Thr Lys Lys Glu Glu Arg Asn Pro Leu Asn Asn Ile His Asp Leu Ser 
        595                 600                 605             
Gln Leu Glu Asn Val Pro Asp Glu Met Asn Gln Met Phe Ser Pro Pro 
    610                 615                 620                 
Leu Lys Ser Met Asn Arg Pro Asp Ala Ile Arg Glu Asn Ser Ser Ser 
625                 630                 635                 640 
Ser Asn Phe Ile Ile Gln Gly Asn Ser Met Ile Ser Thr Pro Ser Gly 
                645                 650                 655     
Arg Asn Asp Leu Pro Asp Thr Ser Pro Met Ser Ser Ile Gln Thr Ala 
            660                 665                 670         
Ser Pro Pro Ser Gln Leu Leu Thr Asp Gln Gly Phe Ala Asp Leu Asp 
        675                 680                 685             
Asn Phe Met Ser Ser Leu 
    690                 

<210> 47
<211> 1089
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acids LEU2.Kl

<400> 47
atgtctaaga atatcgttgt cctaccgggt gatcacgtcg gtaaagaagt tactgacgaa      60

gctattaagg tcttgaatgc cattgctgaa gtccgtccag aaattaagtt caatttccaa     120

catcacttga tcgggggtgc tgccatcgat gccactggca ctcctttacc agatgaagct     180

ctagaagcct ctaagaaagc cgatgctgtc ttactaggtg ctgttggtgg tccaaaatgg     240

ggtacgggcg cagttagacc agaacaaggt ctattgaaga tcagaaagga attgggtcta     300

tacgccaact tgagaccatg taactttgct tctgattctt tactagatct ttctcctttg     360

aagcctgaat atgcaaaggg taccgatttc gtcgtcgtta gagaattggt tggtggtatc     420

tactttggtg aaagaaaaga agatgaaggt gacggagttg cttgggactc tgagaaatac     480

agtgttcctg aagttcaaag aattacaaga atggctgctt tcttggcatt gcaacaaaac     540

ccaccattac caatctggtc tcttgacaag gctaacgtgc ttgcctcttc cagattgtgg     600

agaaagactg ttgaagaaac catcaagact gagttcccac aattaactgt tcagcaccaa     660

ttgatcgact ctgctgctat gattttggtt aaatcaccaa ctaagctaaa cggtgttgtt     720

attaccaaca acatgtttgg tgatattatc tccgatgaag cctctgttat tccaggttct     780

ttgggtttat taccttctgc atctctagct tccctacctg acactaacaa ggcattcggt     840

ttgtacgaac catgtcatgg ttctgcccca gatttaccag caaacaaggt taacccaatt     900

gctaccatct tatctgcagc tatgatgttg aagttatcct tggatttggt tgaagaaggt     960

agggctcttg aagaagctgt tagaaatgtc ttggatgcag gtgtcagaac cggtgacctt    1020

ggtggttcta actctaccac tgaggttggc gatgctatcg ccaaggctgt caaggaaatc    1080

ttggcttaa                                                            1089


<210> 48
<211> 362
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid LEU2.Kl

<400> 48
Met Ser Lys Asn Ile Val Val Leu Pro Gly Asp His Val Gly Lys Glu 
1               5                   10                  15      
Val Thr Asp Glu Ala Ile Lys Val Leu Asn Ala Ile Ala Glu Val Arg 
            20                  25                  30          
Pro Glu Ile Lys Phe Asn Phe Gln His His Leu Ile Gly Gly Ala Ala 
        35                  40                  45              
Ile Asp Ala Thr Gly Thr Pro Leu Pro Asp Glu Ala Leu Glu Ala Ser 
    50                  55                  60                  
Lys Lys Ala Asp Ala Val Leu Leu Gly Ala Val Gly Gly Pro Lys Trp 
65                  70                  75                  80  
Gly Thr Gly Ala Val Arg Pro Glu Gln Gly Leu Leu Lys Ile Arg Lys 
                85                  90                  95      
Glu Leu Gly Leu Tyr Ala Asn Leu Arg Pro Cys Asn Phe Ala Ser Asp 
            100                 105                 110         
Ser Leu Leu Asp Leu Ser Pro Leu Lys Pro Glu Tyr Ala Lys Gly Thr 
        115                 120                 125             
Asp Phe Val Val Val Arg Glu Leu Val Gly Gly Ile Tyr Phe Gly Glu 
    130                 135                 140                 
Arg Lys Glu Asp Glu Gly Asp Gly Val Ala Trp Asp Ser Glu Lys Tyr 
145                 150                 155                 160 
Ser Val Pro Glu Val Gln Arg Ile Thr Arg Met Ala Ala Phe Leu Ala 
                165                 170                 175     
Leu Gln Gln Asn Pro Pro Leu Pro Ile Trp Ser Leu Asp Lys Ala Asn 
            180                 185                 190         
Val Leu Ala Ser Ser Arg Leu Trp Arg Lys Thr Val Glu Glu Thr Ile 
        195                 200                 205             
Lys Thr Glu Phe Pro Gln Leu Thr Val Gln His Gln Leu Ile Asp Ser 
    210                 215                 220                 
Ala Ala Met Ile Leu Val Lys Ser Pro Thr Lys Leu Asn Gly Val Val 
225                 230                 235                 240 
Ile Thr Asn Asn Met Phe Gly Asp Ile Ile Ser Asp Glu Ala Ser Val 
                245                 250                 255     
Ile Pro Gly Ser Leu Gly Leu Leu Pro Ser Ala Ser Leu Ala Ser Leu 
            260                 265                 270         
Pro Asp Thr Asn Lys Ala Phe Gly Leu Tyr Glu Pro Cys His Gly Ser 
        275                 280                 285             
Ala Pro Asp Leu Pro Ala Asn Lys Val Asn Pro Ile Ala Thr Ile Leu 
    290                 295                 300                 
Ser Ala Ala Met Met Leu Lys Leu Ser Leu Asp Leu Val Glu Glu Gly 
305                 310                 315                 320 
Arg Ala Leu Glu Glu Ala Val Arg Asn Val Leu Asp Ala Gly Val Arg 
                325                 330                 335     
Thr Gly Asp Leu Gly Gly Ser Asn Ser Thr Thr Glu Val Gly Asp Ala 
            340                 345                 350         
Ile Ala Lys Ala Val Lys Glu Ile Leu Ala 
        355                 360         

<210> 49
<211> 654
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid His 5

<400> 49
atgggtagga gggcttttgt agaaagaaat acgaacgaaa cgaaaatcag cgttgccatc      60

gctttggaca aagctccctt acctgaagag tcgaatttta ttgatgaact tataacttcc     120

aagcatgcaa accaaaaggg agaacaagta atccaagtag acacgggaat tggattcttg     180

gatcacatgt atcatgcact ggctaaacat gcaggctgga gcttacgact ttactcaaga     240

ggtgatttaa tcatcgatga tcatcacact gcagaagata ctgctattgc acttggtatt     300

gcattcaagc aggctatggg taactttgcc ggcgttaaaa gatttggaca tgcttattgt     360

ccacttgacg aagctctttc tagaagcgta gttgacttgt cgggacggcc ctatgctgtt     420

atcgatttgg gattaaagcg tgaaaaggtt ggggaattgt cctgtgaaat gatccctcac     480

ttactatatt ccttttcggt agcagctgga attactttgc atgttacctg cttatatggt     540

agtaatgacc atcatcgtgc tgaaagcgct tttaaatctc tggctgttgc catgcgcgcg     600

gctactagtc ttactggaag ttctgaagtc ccaagcacga agggagtgtt gtaa           654


<210> 50
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid His 5

<400> 50
Met Gly Arg Arg Ala Phe Val Glu Arg Asn Thr Asn Glu Thr Lys Ile 
1               5                   10                  15      
Ser Val Ala Ile Ala Leu Asp Lys Ala Pro Leu Pro Glu Glu Ser Asn 
            20                  25                  30          
Phe Ile Asp Glu Leu Ile Thr Ser Lys His Ala Asn Gln Lys Gly Glu 
        35                  40                  45              
Gln Val Ile Gln Val Asp Thr Gly Ile Gly Phe Leu Asp His Met Tyr 
    50                  55                  60                  
His Ala Leu Ala Lys His Ala Gly Trp Ser Leu Arg Leu Tyr Ser Arg 
65                  70                  75                  80  
Gly Asp Leu Ile Ile Asp Asp His His Thr Ala Glu Asp Thr Ala Ile 
                85                  90                  95      
Ala Leu Gly Ile Ala Phe Lys Gln Ala Met Gly Asn Phe Ala Gly Val 
            100                 105                 110         
Lys Arg Phe Gly His Ala Tyr Cys Pro Leu Asp Glu Ala Leu Ser Arg 
        115                 120                 125             
Ser Val Val Asp Leu Ser Gly Arg Pro Tyr Ala Val Ile Asp Leu Gly 
    130                 135                 140                 
Leu Lys Arg Glu Lys Val Gly Glu Leu Ser Cys Glu Met Ile Pro His 
145                 150                 155                 160 
Leu Leu Tyr Ser Phe Ser Val Ala Ala Gly Ile Thr Leu His Val Thr 
                165                 170                 175     
Cys Leu Tyr Gly Ser Asn Asp His His Arg Ala Glu Ser Ala Phe Lys 
            180                 185                 190         
Ser Leu Ala Val Ala Met Arg Ala Ala Thr Ser Leu Thr Gly Ser Ser 
        195                 200                 205             
Glu Val Pro Ser Thr Lys Gly Val Leu 
    210                 215         

<210> 51
<211> 633
<212> DNA
<213> Artificial Sequence

<220> 
<223> nucleic acid Trp1 kl

<400> 51
atgctcgtta aagtgtgtgg tttgcaaacc gttgaagctg caaagactgc tgtggatgat      60

ggtgctgatt acttaggtat catttgtgtt cccggtagga aaagaaccat tgactcatct     120

gttgcgaaag gtatttcaac tgcagttcac caacaagaga acgtgaaagg tactaaacta     180

gtcggggtgt ttagaaatca gtccgttgat gatgtccttc aactgtacca cgaatataat     240

ctagatgtga tacaattaca tggagatgaa gatattaaag aatacagatc tttgatccca     300

tcttcaattc caatcattaa gaggttccag ttcccacagg attgtgaatt actactggac     360

ctgtatgaac acgtagacaa tgtgctgacg ttgttcgatt ctggtgaagg tggcactggt     420

gagaaattga attggagtgc aatttccagt tggtctgcaa gtcatcccga gataaaattc     480

attatcgctg gtggattgaa tcctgataac gtttctgttg ccattaatat gttaccaaat     540

gcgatcggtg tcgatgtaag tggaggagta gagactgatg gtatcaagga tttagaaaag     600

gtaaagctat tcatccagca ggcctctcaa tag                                  633


<210> 52
<211> 210
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid Trp1 Kl

<400> 52
Met Leu Val Lys Val Cys Gly Leu Gln Thr Val Glu Ala Ala Lys Thr 
1               5                   10                  15      
Ala Val Asp Asp Gly Ala Asp Tyr Leu Gly Ile Ile Cys Val Pro Gly 
            20                  25                  30          
Arg Lys Arg Thr Ile Asp Ser Ser Val Ala Lys Gly Ile Ser Thr Ala 
        35                  40                  45              
Val His Gln Gln Glu Asn Val Lys Gly Thr Lys Leu Val Gly Val Phe 
    50                  55                  60                  
Arg Asn Gln Ser Val Asp Asp Val Leu Gln Leu Tyr His Glu Tyr Asn 
65                  70                  75                  80  
Leu Asp Val Ile Gln Leu His Gly Asp Glu Asp Ile Lys Glu Tyr Arg 
                85                  90                  95      
Ser Leu Ile Pro Ser Ser Ile Pro Ile Ile Lys Arg Phe Gln Phe Pro 
            100                 105                 110         
Gln Asp Cys Glu Leu Leu Leu Asp Leu Tyr Glu His Val Asp Asn Val 
        115                 120                 125             
Leu Thr Leu Phe Asp Ser Gly Glu Gly Gly Thr Gly Glu Lys Leu Asn 
    130                 135                 140                 
Trp Ser Ala Ile Ser Ser Trp Ser Ala Ser His Pro Glu Ile Lys Phe 
145                 150                 155                 160 
Ile Ile Ala Gly Gly Leu Asn Pro Asp Asn Val Ser Val Ala Ile Asn 
                165                 170                 175     
Met Leu Pro Asn Ala Ile Gly Val Asp Val Ser Gly Gly Val Glu Thr 
            180                 185                 190         
Asp Gly Ile Lys Asp Leu Glu Lys Val Lys Leu Phe Ile Gln Gln Ala 
        195                 200                 205             
Ser Gln 
    210 

