                         SEQUENCE LISTING

<110>  Advaxis, Inc.
 
<120>  BIVALENT LISTERIA-BASED DELIVERY SYSTEM OF HETEROLOGOUS ANTIGENS

<130>  P-70988-PC2

<140>  PCT/US15/999999
<141>  2015-07-17

<150>  14/341,215
<151>  2014-07-25

<150>  62/026,085
<151>  2014-07-18

<150>  62/076,406
<151>  2014-11-06

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  6733
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid backbone sequence

<400>  1
ggagtgtata ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt       60

ggcaggagaa aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc      120

gcttcctcgc tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct      180

tacgaacggg gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga      240

gggccgcggc aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct      300

gacgctcaaa tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc      360

ctggcggctc cctcgtgcgc tctcctgttc ctgcctttcg gtttaccggt gtcattccgc      420

tgttatggcc gcgtttgtct cattccacgc ctgacactca gttccgggta ggcagttcgc      480

tccaagctgg actgtatgca cgaacccccc gttcagtccg accgctgcgc cttatccggt      540

aactatcgtc ttgagtccaa cccggaaaga catgcaaaag caccactggc agcagccact      600

ggtaattgat ttagaggagt tagtcttgaa gtcatgcgcc ggttaaggct aaactgaaag      660

gacaagtttt ggtgactgcg ctcctccaag ccagttacct cggttcaaag agttggtagc      720

tcagagaacc ttcgaaaaac cgccctgcaa ggcggttttt tcgttttcag agcaagagat      780

tacgcgcaga ccaaaacgat ctcaagaaga tcatcttatt aatcagataa aatatttcta      840

gccctccttt gattagtata ttcctatctt aaagttactt ttatgtggag gcattaacat      900

ttgttaatga cgtcaaaagg atagcaagac tagaataaag ctataaagca agcatataat      960

attgcgtttc atctttagaa gcgaatttcg ccaatattat aattatcaaa agagaggggt     1020

ggcaaacggt atttggcatt attaggttaa aaaatgtaga aggagagtga aacccatgaa     1080

aaaaataatg ctagttttta ttacacttat attagttagt ctaccaattg cgcaacaaac     1140

tgaagcaaag gatgcatctg cattcaataa agaaaattca atttcatcca tggcaccacc     1200

agcatctccg cctgcaagtc ctaagacgcc aatcgaaaag aaacacgcgg atgaaatcga     1260

taagtatata caaggattgg attacaataa aaacaatgta ttagtatacc acggagatgc     1320

agtgacaaat gtgccgccaa gaaaaggtta caaagatgga aatgaatata ttgttgtgga     1380

gaaaaagaag aaatccatca atcaaaataa tgcagacatt caagttgtga atgcaatttc     1440

gagcctaacc tatccaggtg ctctcgtaaa agcgaattcg gaattagtag aaaatcaacc     1500

agatgttctc cctgtaaaac gtgattcatt aacactcagc attgatttgc caggtatgac     1560

taatcaagac aataaaatag ttgtaaaaaa tgccactaaa tcaaacgtta acaacgcagt     1620

aaatacatta gtggaaagat ggaatgaaaa atatgctcaa gcttatccaa atgtaagtgc     1680

aaaaattgat tatgatgacg aaatggctta cagtgaatca caattaattg cgaaatttgg     1740

tacagcattt aaagctgtaa ataatagctt gaatgtaaac ttcggcgcaa tcagtgaagg     1800

gaaaatgcaa gaagaagtca ttagttttaa acaaatttac tataacgtga atgttaatga     1860

acctacaaga ccttccagat ttttcggcaa agctgttact aaagagcagt tgcaagcgct     1920

tggagtgaat gcagaaaatc ctcctgcata tatctcaagt gtggcgtatg gccgtcaagt     1980

ttatttgaaa ttatcaacta attcccatag tactaaagta aaagctgctt ttgatgctgc     2040

cgtaagcgga aaatctgtct caggtgatgt agaactaaca aatatcatca aaaattcttc     2100

cttcaaagcc gtaatttacg gaggttccgc aaaagatgaa gttcaaatca tcgacggcaa     2160

cctcggagac ttacgcgata ttttgaaaaa aggcgctact tttaatcgag aaacaccagg     2220

agttcccatt gcttatacaa caaacttcct aaaagacaat gaattagctg ttattaaaaa     2280

caactcagaa tatattgaaa caacttcaaa agcttataca gatggaaaaa ttaacatcga     2340

tcactctgga ggatacgttg ctcaattcaa catttcttgg gatgaagtaa attatgatct     2400

cgagactagt tctagattta tcacgtaccc atttccccgc atcttttatt tttttaaata     2460

ctttagggaa aaatggtttt tgatttgctt ttaaaggttg tggtgtagac tcgtctgctg     2520

actgcatgct agaatctaag tcactttcag aagcatccac aactgactct ttcgccactt     2580

ttctcttatt tgcttttgtt ggtttatctg gataagtaag gctttcaagc tcactatccg     2640

acgacgctat ggcttttctt ctttttttaa tttccgctgc gctatccgat gacagacctg     2700

gatgacgacg ctccacttgc agagttggtc ggtcgactcc tgaagcctct tcatttatag     2760

ccacatttcc tgtttgctca ccgttgttat tattgttatt cggacctttc tctgcttttg     2820

ctttcaacat tgctattagg tctgctttgt tcgtattttt cactttattc gatttttcta     2880

gttcctcaat atcacgtgaa cttacttcac gtgcagtttc gtatcttggt cccgtattta     2940

cctcgcttgg ctgctcttct gttttttctt cttcccattc atctgtgttt agactggaat     3000

cttcgctatc tgtcgctgca aatattatgt cggggttaat cgtaatgcag ttggcagtaa     3060

tgaaaactac catcatcgca cgcataaatc tgtttaatcc cacttatact ccctcctcgt     3120

gatacgctaa tacaaccttt ttagaacaag gaaaattcgg ccttcatttt cactaatttg     3180

ttccgttaaa aattggatta gcagttagtt atcttcttaa ttagctaata taagaaaaaa     3240

tattcatgaa ttattttaag aatatcactt ggagaattaa tttttctcta acatttgtta     3300

atcagttaac cccaactgct tcccaagctt cacccgggcc actaactcaa cgctagtagt     3360

ggatttaatc ccaaatgagc caacagaacc agaaccagaa acagaacaag taacattgga     3420

gttagaaatg gaagaagaaa aaagcaatga tttcgtgtga ataatgcacg aaatcattgc     3480

ttattttttt aaaaagcgat atactagata taacgaaaca acgaactgaa taaagaatac     3540

aaaaaaagag ccacgaccag ttaaagcctg agaaacttta actgcgagcc ttaattgatt     3600

accaccaatc aattaaagaa gtcgagaccc aaaatttggt aaagtattta attactttat     3660

taatcagata cttaaatatc tgtaaaccca ttatatcggg tttttgaggg gatttcaagt     3720

ctttaagaag ataccaggca atcaattaag aaaaacttag ttgattgcct tttttgttgt     3780

gattcaactt tgatcgtagc ttctaactaa ttaattttcg taagaaagga gaacagctga     3840

atgaatatcc cttttgttgt agaaactgtg cttcatgacg gcttgttaaa gtacaaattt     3900

aaaaatagta aaattcgctc aatcactacc aagccaggta aaagtaaagg ggctattttt     3960

gcgtatcgct caaaaaaaag catgattggc ggacgtggcg ttgttctgac ttccgaagaa     4020

gcgattcacg aaaatcaaga tacatttacg cattggacac caaacgttta tcgttatggt     4080

acgtatgcag acgaaaaccg ttcatacact aaaggacatt ctgaaaacaa tttaagacaa     4140

atcaatacct tctttattga ttttgatatt cacacggaaa aagaaactat ttcagcaagc     4200

gatattttaa caacagctat tgatttaggt tttatgccta cgttaattat caaatctgat     4260

aaaggttatc aagcatattt tgttttagaa acgccagtct atgtgacttc aaaatcagaa     4320

tttaaatctg tcaaagcagc caaaataatc tcgcaaaata tccgagaata ttttggaaag     4380

tctttgccag ttgatctaac gtgcaatcat tttgggattg ctcgtatacc aagaacggac     4440

aatgtagaat tttttgatcc caattaccgt tattctttca aagaatggca agattggtct     4500

ttcaaacaaa cagataataa gggctttact cgttcaagtc taacggtttt aagcggtaca     4560

gaaggcaaaa aacaagtaga tgaaccctgg tttaatctct tattgcacga aacgaaattt     4620

tcaggagaaa agggtttagt agggcgcaat agcgttatgt ttaccctctc tttagcctac     4680

tttagttcag gctattcaat cgaaacgtgc gaatataata tgtttgagtt taataatcga     4740

ttagatcaac ccttagaaga aaaagaagta atcaaaattg ttagaagtgc ctattcagaa     4800

aactatcaag gggctaatag ggaatacatt accattcttt gcaaagcttg ggtatcaagt     4860

gatttaacca gtaaagattt atttgtccgt caagggtggt ttaaattcaa gaaaaaaaga     4920

agcgaacgtc aacgtgttca tttgtcagaa tggaaagaag atttaatggc ttatattagc     4980

gaaaaaagcg atgtatacaa gccttattta gcgacgacca aaaaagagat tagagaagtg     5040

ctaggcattc ctgaacggac attagataaa ttgctgaagg tactgaaggc gaatcaggaa     5100

attttcttta agattaaacc aggaagaaat ggtggcattc aacttgctag tgttaaatca     5160

ttgttgctat cgatcattaa attaaaaaaa gaagaacgag aaagctatat aaaggcgctg     5220

acagcttcgt ttaatttaga acgtacattt attcaagaaa ctctaaacaa attggcagaa     5280

cgccccaaaa cggacccaca actcgatttg tttagctacg atacaggctg aaaataaaac     5340

ccgcactatg ccattacatt tatatctatg atacgtgttt gtttttcttt gctggctagc     5400

ttaattgctt atatttacct gcaataaagg atttcttact tccattatac tcccattttc     5460

caaaaacata cggggaacac gggaacttat tgtacaggcc acctcatagt taatggtttc     5520

gagccttcct gcaatctcat ccatggaaat atattcatcc ccctgccggc ctattaatgt     5580

gacttttgtg cccggcggat attcctgatc cagctccacc ataaattggt ccatgcaaat     5640

tcggccggca attttcaggc gttttccctt cacaaggatg tcggtccctt tcaattttcg     5700

gagccagccg tccgcatagc ctacaggcac cgtcccgatc catgtgtctt tttccgctgt     5760

gtactcggct ccgtagctga cgctctcgcc ttttctgatc agtttgacat gtgacagtgt     5820

cgaatgcagg gtaaatgccg gacgcagctg aaacggtatc tcgtccgaca tgtcagcaga     5880

cgggcgaagg ccatacatgc cgatgccgaa tctgactgca ttaaaaaagc cttttttcag     5940

ccggagtcca gcggcgctgt tcgcgcagtg gaccattaga ttctttaacg gcagcggagc     6000

aatcagctct ttaaagcgct caaactgcat taagaaatag cctctttctt tttcatccgc     6060

tgtcgcaaaa tgggtaaata cccctttgca ctttaaacga gggttgcggt caagaattgc     6120

catcacgttc tgaacttctt cctctgtttt tacaccaagt ctgttcatcc ccgtatcgac     6180

cttcagatga aaatgaagag aacctttttt cgtgtggcgg gctgcctcct gaagccattc     6240

aacagaataa cctgttaagg tcacgtcata ctcagcagcg attgccacat actccggggg     6300

aaccgcgcca agcaccaata taggcgcctt caatcccttt ttgcgcagtg aaatcgcttc     6360

atccaaaatg gccacggcca agcatgaagc acctgcgtca agagcagcct ttgctgtttc     6420

tgcatcacca tgcccgtagg cgtttgcttt cacaactgcc atcaagtgga catgttcacc     6480

gatatgtttt ttcatattgc tgacattttc ctttatcacg gacaagtcaa tttccgccca     6540

cgtatctctg taaaaaggtt ttgtgctcat ggaaaactcc tctctttttt cagaaaatcc     6600

cagtacgtaa ttaagtattt gagaattaat tttatattga ttaatactaa gtttacccag     6660

ttttcaccta aaaaacaaat gatgagataa tagctccaaa ggctaaagag gactatacca     6720

actatttgtt aat                                                        6733


<210>  2
<211>  2850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding cHER-2/endogenous LLO fusion

<400>  2
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccgtggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta ttcaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatcctgaag gtaacgaaat tgttcaacat aaaaactgga gcgaaaacaa taaaagcaag     1380

ctagctcatt tcacatcgtc catctatttg cctggtaacg cgagaaatat taatgtttac     1440

gctaaagaat gcactggttt agcttgggaa tggtggagaa cggtaattga tgaccggaac     1500

ttaccacttg tgaaaaatag aaatatctcc atctggggca ccacgcttta tccgaaatat     1560

agtaataaag tagataatcc aatcgaagtc gacacccacc tggacatgct ccgccacctc     1620

taccagggct gccaggtggt gcagggaaac ctggaactca cctacctgcc caccaatgcc     1680

agcctgtcct tcctgcagga tatccaggag gtgcagggct acgtgctcat cgctcacaac     1740

caagtgaggc aggtcccact gcagaggctg cggattgtgc gaggcaccca gctctttgag     1800

gacaactatg ccctggccgt gctagacaat ggagacccgc tgaacaatac cacccctgtc     1860

acaggggcct ccccaggagg cctgcgggag ctgcagcttc gaagcctcac agagatcttg     1920

aaaggagggg tcttgatcca gcggaacccc cagctctgct accaggacac gattttgtgg     1980

aagaatatcc aggagtttgc tggctgcaag aagatctttg ggagcctggc atttctgccg     2040

gagagctttg atggggaccc agcctccaac actgccccgc tccagccaga gcagctccaa     2100

gtgtttgaga ctctggaaga gatcacaggt tacctataca tctcagcatg gccggacagc     2160

ctgcctgacc tcagcgtctt ccagaacctg caagtaatcc ggggacgaat tctgcacaat     2220

ggcgcctact cgctgaccct gcaagggctg ggcatcagct ggctggggct gcgctcactg     2280

agggaactgg gcagtggact ggccctcatc caccataaca cccacctctg cttcgtgcac     2340

acggtgccct gggaccagct ctttcggaac ccgcaccaag ctctgctcca cactgccaac     2400

cggccagagg acgagtgtgt gggcgagggc ctggcctgcc accagctgtg cgcccgaggg     2460

cagcagaaga tccggaagta cacgatgcgg agactgctgc aggaaacgga gctggtggag     2520

ccgctgacac ctagcggagc gatgcccaac caggcgcaga tgcggatcct gaaagagacg     2580

gagctgagga aggtgaaggt gcttggatct ggcgcttttg gcacagtcta caagggcatc     2640

tggatccctg atggggagaa tgtgaaaatt ccagtggcca tcaaagtgtt gagggaaaac     2700

acatccccca aagccaacaa agaaatctta gacgaagcat acgtgatggc tggtgtgggc     2760

tccccatatg tctcccgcct tctgggcatc tgcctgacat ccacggtgca gctggtgaca     2820

cagcttatgc cctatggctg cctcttagac                                      2850


<210>  3
<211>  950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cHER-2/endogenous LLO fusion amino acid sequence

<400>  3

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu Val Asp Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys 
    530                 535                 540                 


Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala 
545                 550                 555                 560 


Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu 
                565                 570                 575     


Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile 
            580                 585                 590         


Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu 
        595                 600                 605             


Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser 
    610                 615                 620                 


Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu 
625                 630                 635                 640 


Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp 
                645                 650                 655     


Thr Ile Leu Trp Lys Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile 
            660                 665                 670         


Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala 
        675                 680                 685             


Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr 
    690                 695                 700                 


Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser 
705                 710                 715                 720 


Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg 
                725                 730                 735     


Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile 
            740                 745                 750         


Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala 
        755                 760                 765             


Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp 
    770                 775                 780                 


Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn 
785                 790                 795                 800 


Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu 
                805                 810                 815     


Cys Ala Arg Gly Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu 
            820                 825                 830         


Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met 
        835                 840                 845             


Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys 
    850                 855                 860                 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
865                 870                 875                 880 


Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val 
                885                 890                 895     


Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu 
            900                 905                 910         


Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu 
        915                 920                 925             


Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro 
    930                 935                 940                 


Tyr Gly Cys Leu Leu Asp 
945                 950 


<210>  4
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  4

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  5
<211>  2586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding tLLO/cHER2 fusion protein

<400>  5
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatctcgaga cccacctgga catgctccgc cacctctacc agggctgcca ggtggtgcag     1380

ggaaacctgg aactcaccta cctgcccacc aatgccagcc tgtccttcct gcaggatatc     1440

caggaggtgc agggctacgt gctcatcgct cacaaccaag tgaggcaggt cccactgcag     1500

aggctgcgga ttgtgcgagg cacccagctc tttgaggaca actatgccct ggccgtgcta     1560

gacaatggag acccgctgaa caataccacc cctgtcacag gggcctcccc aggaggcctg     1620

cgggagctgc agcttcgaag cctcacagag atcttgaaag gaggggtctt gatccagcgg     1680

aacccccagc tctgctacca ggacacgatt ttgtggaaga atatccagga gtttgctggc     1740

tgcaagaaga tctttgggag cctggcattt ctgccggaga gctttgatgg ggacccagcc     1800

tccaacactg ccccgctcca gccagagcag ctccaagtgt ttgagactct ggaagagatc     1860

acaggttacc tatacatctc agcatggccg gacagcctgc ctgacctcag cgtcttccag     1920

aacctgcaag taatccgggg acgaattctg cacaatggcg cctactcgct gaccctgcaa     1980

gggctgggca tcagctggct ggggctgcgc tcactgaggg aactgggcag tggactggcc     2040

ctcatccacc ataacaccca cctctgcttc gtgcacacgg tgccctggga ccagctcttt     2100

cggaacccgc accaagctct gctccacact gccaaccggc cagaggacga gtgtgtgggc     2160

gagggcctgg cctgccacca gctgtgcgcc cgagggcagc agaagatccg gaagtacacg     2220

atgcggagac tgctgcagga aacggagctg gtggagccgc tgacacctag cggagcgatg     2280

cccaaccagg cgcagatgcg gatcctgaaa gagacggagc tgaggaaggt gaaggtgctt     2340

ggatctggcg cttttggcac agtctacaag ggcatctgga tccctgatgg ggagaatgtg     2400

aaaattccag tggccatcaa agtgttgagg gaaaacacat cccccaaagc caacaaagaa     2460

atcttagacg aagcatacgt gatggctggt gtgggctccc catatgtctc ccgccttctg     2520

ggcatctgcc tgacatccac ggtgcagctg gtgacacagc ttatgcccta tggctgcctc     2580

ttagac                                                                2586


<210>  6
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tLLO/cHER2 fusion protein

<400>  6

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Leu Glu Thr His Leu Asp Met 
        435                 440                 445             


Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu 
    450                 455                 460                 


Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile 
465                 470                 475                 480 


Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln 
                485                 490                 495     


Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu 
            500                 505                 510         


Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn 
        515                 520                 525             


Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln 
    530                 535                 540                 


Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg 
545                 550                 555                 560 


Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asn Ile Gln 
                565                 570                 575     


Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro 
            580                 585                 590         


Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro 
        595                 600                 605             


Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu 
    610                 615                 620                 


Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln 
625                 630                 635                 640 


Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser 
                645                 650                 655     


Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu 
            660                 665                 670         


Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu 
        675                 680                 685             


Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His 
    690                 695                 700                 


Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly 
705                 710                 715                 720 


<210>  7
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tLLO

<400>  7

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp 
        435                 440     


<210>  8
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding tLLO fused to HMW-MAA-C (HMC)

<400>  8
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatctcgagg ccactgagcc ttacaatgct gcccggccct acagcgtggc cctgctcagt     1380

gtccccgagg ccgcccggac ggaagcaggg aagccagaga gcagcacccc cacaggcgag     1440

ccaggcccca tggcatccag ccctgagccc gctgtggcca agggaggctt cctgagcttc     1500

cttgaggcca acatgttcag cgtcatcatc cccatgtgcc tggtacttct gctcctggcg     1560

ctcatcctgc ccctgctctt ctacctccga aaacgcaaca agacgggcaa gcatgacgtc     1620

caggattaca aggatgacga cgataag                                         1647


<210>  9
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tLLO fused to HMW-MAA-C (HMC)

<400>  9

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Leu Glu Ala Thr Glu Pro Tyr 
        435                 440                 445             


Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu Ser Val Pro Glu Ala 
    450                 455                 460                 


Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser Thr Pro Thr Gly Glu 
465                 470                 475                 480 


Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala Val Ala Lys Gly Gly 
                485                 490                 495     


Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser Val Ile Ile Pro Met 
            500                 505                 510         


Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu Pro Leu Leu Phe Tyr 
        515                 520                 525             


Leu Arg Lys Arg Asn Lys Thr Gly Lys His Asp Val Gln Asp Tyr Lys 
    530                 535                 540                 


Asp Asp Asp Asp Lys 
545                 


<210>  10
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA-C (HMC)

<400>  10

Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu 
1               5                   10                  15      


Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser 
            20                  25                  30          


Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala 
        35                  40                  45              


Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser 
    50                  55                  60                  


Val Ile Ile Pro Met Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu 
65                  70                  75                  80  


Pro Leu Leu Phe Tyr Leu Arg Lys Arg Asn Lys Thr Gly Lys His Asp 
                85                  90                  95      


Val Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
            100                 105     


<210>  11
<211>  8317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid sequence encoding 2 antigens

<400>  11
ggagtgtata ctggcttact atgttggcac tgatgagggt gtcagtgaag tgcttcatgt       60

ggcaggagaa aaaaggctgc accggtgcgt cagcagaata tgtgatacag gatatattcc      120

gcttcctcgc tcactgactc gctacgctcg gtcgttcgac tgcggcgagc ggaaatggct      180

tacgaacggg gcggagattt cctggaagat gccaggaaga tacttaacag ggaagtgaga      240

gggccgcggc aaagccgttt ttccataggc tccgcccccc tgacaagcat cacgaaatct      300

gacgctcaaa tcagtggtgg cgaaacccga caggactata aagataccag gcgtttcccc      360

ctggcggctc cctcgtgcgc tctcctgttc ctgcctttcg gtttaccggt gtcattccgc      420

tgttatggcc gcgtttgtct cattccacgc ctgacactca gttccgggta ggcagttcgc      480

tccaagctgg actgtatgca cgaacccccc gttcagtccg accgctgcgc cttatccggt      540

aactatcgtc ttgagtccaa cccggaaaga catgcaaaag caccactggc agcagccact      600

ggtaattgat ttagaggagt tagtcttgaa gtcatgcgcc ggttaaggct aaactgaaag      660

gacaagtttt ggtgactgcg ctcctccaag ccagttacct cggttcaaag agttggtagc      720

tcagagaacc ttcgaaaaac cgccctgcaa ggcggttttt tcgttttcag agcaagagat      780

tacgcgcaga ccaaaacgat ctcaagaaga tcatcttatt aatcagataa aatatttcta      840

gccctccttt gattagtata ttcctatctt aaagttactt ttatgtggag gcattaacat      900

ttgttaatga cgtcaaaagg atagcaagac tagaataaag ctataaagca agcatataat      960

attgcgtttc atctttagaa gcgaatttcg ccaatattat aattatcaaa agagaggggt     1020

ggcaaacggt atttggcatt attaggttaa aaaatgtaga aggagagtga aacccatgaa     1080

aaaaataatg ctagttttta ttacacttat attagttagt ctaccaattg cgcaacaaac     1140

tgaagcaaag gatgcatctg cattcaataa agaaaattca atttcatcca tggcaccacc     1200

agcatctccg cctgcaagtc ctaagacgcc aatcgaaaag aaacacgcgg atgaaatcga     1260

taagtatata caaggattgg attacaataa aaacaatgta ttagtatacc acggagatgc     1320

agtgacaaat gtgccgccaa gaaaaggtta caaagatgga aatgaatata ttgttgtgga     1380

gaaaaagaag aaatccatca atcaaaataa tgcagacatt caagttgtga atgcaatttc     1440

gagcctaacc tatccaggtg ctctcgtaaa agcgaattcg gaattagtag aaaatcaacc     1500

agatgttctc cctgtaaaac gtgattcatt aacactcagc attgatttgc caggtatgac     1560

taatcaagac aataaaatag ttgtaaaaaa tgccactaaa tcaaacgtta acaacgcagt     1620

aaatacatta gtggaaagat ggaatgaaaa atatgctcaa gcttatccaa atgtaagtgc     1680

aaaaattgat tatgatgacg aaatggctta cagtgaatca caattaattg cgaaatttgg     1740

tacagcattt aaagctgtaa ataatagctt gaatgtaaac ttcggcgcaa tcagtgaagg     1800

gaaaatgcaa gaagaagtca ttagttttaa acaaatttac tataacgtga atgttaatga     1860

acctacaaga ccttccagat ttttcggcaa agctgttact aaagagcagt tgcaagcgct     1920

tggagtgaat gcagaaaatc ctcctgcata tatctcaagt gtggcgtatg gccgtcaagt     1980

ttatttgaaa ttatcaacta attcccatag tactaaagta aaagctgctt ttgatgctgc     2040

cgtaagcgga aaatctgtct caggtgatgt agaactaaca aatatcatca aaaattcttc     2100

cttcaaagcc gtaatttacg gaggttccgc aaaagatgaa gttcaaatca tcgacggcaa     2160

cctcggagac ttacgcgata ttttgaaaaa aggcgctact tttaatcgag aaacaccagg     2220

agttcccatt gcttatacaa caaacttcct aaaagacaat gaattagctg ttattaaaaa     2280

caactcagaa tatattgaaa caacttcaaa agcttataca gatggaaaaa ttaacatcga     2340

tcactctgga ggatacgttg ctcaattcaa catttcttgg gatgaagtaa attatgatct     2400

cgagcatgga gatacaccta cattgcatga atatatgtta gatttgcaac cagagacaac     2460

tgatctctac tgttatgagc aattaaatga cagctcagag gaggaggatg aaatagatgg     2520

tccagctgga caagcagaac cggacagagc ccattacaat attgtaacct tttgttgcaa     2580

gtgtgactct acgcttcggt tgtgcgtaca aagcacacac gtagacattc gtactttgga     2640

agacctgtta atgggcacac taggaattgt gtgccccatc tgttctcaga aaccataaac     2700

tagtctagtg gtgatggtga tgatggagct cagatctgtc taagaggcag ccatagggca     2760

taagctgtgt caccagctgc accgtggatg tcaggcagat gcccagaagg cgggagacat     2820

atggggagcc cacaccagcc atcacgtatg cttcgtctaa gatttctttg ttggctttgg     2880

gggatgtgtt ttccctcaac actttgatgg ccactggaat tttcacattc tccccatcag     2940

ggatccagat gcccttgtag actgtgccaa aagcgccaga tccaagcacc ttcaccttcc     3000

tcagctccgt ctctttcagg atccgcatct gcgcctggtt gggcatcgct ccgctaggtg     3060

tcagcggctc caccagctcc gtttcctgca gcagtctccg catcgtgtac ttccggatct     3120

tctgctgccc tcgggcgcac agctggtggc aggccaggcc ctcgcccaca cactcgtcct     3180

ctggccggtt ggcagtgtgg agcagagctt ggtgcgggtt ccgaaagagc tggtcccagg     3240

gcaccgtgtg cacgaagcag aggtgggtgt tatggtggat gagggccagt ccactgccca     3300

gttccctcag tgagcgcagc cccagccagc tgatgcccag cccttgcagg gtcagcgagt     3360

aggcgccatt gtgcagaatt cgtccccgga ttacttgcag gttctggaag acgctgaggt     3420

caggcaggct gtccggccat gctgagatgt ataggtaacc tgtgatctct tccagagtct     3480

caaacacttg gagctgctct ggctggagcg gggcagtgtt ggaggctggg tccccatcaa     3540

agctctccgg cagaaatgcc aggctcccaa agatcttctt gcagccagca aactcctgga     3600

tattcttcca caaaatcgtg tcctggtagc agagctgggg gttccgctgg atcaagaccc     3660

ctcctttcaa gatctctgtg aggcttcgaa gctgcagctc ccgcaggcct cctggggagg     3720

cccctgtgac aggggtggta ttgttcagcg ggtctccatt gtctagcacg gccagggcat     3780

agttgtcctc aaagagctgg gtgcctcgca caatccgcag cctctgcagt gggacctgcc     3840

tcacttggtt gtgagcgatg agcacgtagc cctgcacctc ctggatatcc tgcaggaagg     3900

acaggctggc attggtgggc aggtaggtga gttccaggtt tccctgcacc acctggcagc     3960

cctggtagag gtggcggagc atgtccaggt gggttctaga tttatcacgt acccatttcc     4020

ccgcatcttt tattttttta aatactttag ggaaaaatgg tttttgattt gcttttaaag     4080

gttgtggtgt agactcgtct gctgactgca tgctagaatc taagtcactt tcagaagcat     4140

ccacaactga ctctttcgcc acttttctct tatttgcttt tgttggttta tctggataag     4200

taaggctttc aagctcacta tccgacgacg ctatggcttt tcttcttttt ttaatttccg     4260

ctgcgctatc cgatgacaga cctggatgac gacgctccac ttgcagagtt ggtcggtcga     4320

ctcctgaagc ctcttcattt atagccacat ttcctgtttg ctcaccgttg ttattattgt     4380

tattcggacc tttctctgct tttgctttca acattgctat taggtctgct ttgttcgtat     4440

ttttcacttt attcgatttt tctagttcct caatatcacg tgaacttact tcacgtgcag     4500

tttcgtatct tggtcccgta tttacctcgc ttggctgctc ttctgttttt tcttcttccc     4560

attcatctgt gtttagactg gaatcttcgc tatctgtcgc tgcaaatatt atgtcggggt     4620

taatcgtaat gcagttggca gtaatgaaaa ctaccatcat cgcacgcata aatctgttta     4680

atcccactta tactccctcc tcgtgatacg ctaatacaac ctttttagaa caaggaaaat     4740

tcggccttca ttttcactaa tttgttccgt taaaaattgg attagcagtt agttatcttc     4800

ttaattagct aatataagaa aaaatattca tgaattattt taagaatatc acttggagaa     4860

ttaatttttc tctaacattt gttaatcagt taaccccaac tgcttcccaa gcttcacccg     4920

ggccactaac tcaacgctag tagtggattt aatcccaaat gagccaacag aaccagaacc     4980

agaaacagaa caagtaacat tggagttaga aatggaagaa gaaaaaagca atgatttcgt     5040

gtgaataatg cacgaaatca ttgcttattt ttttaaaaag cgatatacta gatataacga     5100

aacaacgaac tgaataaaga atacaaaaaa agagccacga ccagttaaag cctgagaaac     5160

tttaactgcg agccttaatt gattaccacc aatcaattaa agaagtcgag acccaaaatt     5220

tggtaaagta tttaattact ttattaatca gatacttaaa tatctgtaaa cccattatat     5280

cgggtttttg aggggatttc aagtctttaa gaagatacca ggcaatcaat taagaaaaac     5340

ttagttgatt gccttttttg ttgtgattca actttgatcg tagcttctaa ctaattaatt     5400

ttcgtaagaa aggagaacag ctgaatgaat atcccttttg ttgtagaaac tgtgcttcat     5460

gacggcttgt taaagtacaa atttaaaaat agtaaaattc gctcaatcac taccaagcca     5520

ggtaaaagta aaggggctat ttttgcgtat cgctcaaaaa aaagcatgat tggcggacgt     5580

ggcgttgttc tgacttccga agaagcgatt cacgaaaatc aagatacatt tacgcattgg     5640

acaccaaacg tttatcgtta tggtacgtat gcagacgaaa accgttcata cactaaagga     5700

cattctgaaa acaatttaag acaaatcaat accttcttta ttgattttga tattcacacg     5760

gaaaaagaaa ctatttcagc aagcgatatt ttaacaacag ctattgattt aggttttatg     5820

cctacgttaa ttatcaaatc tgataaaggt tatcaagcat attttgtttt agaaacgcca     5880

gtctatgtga cttcaaaatc agaatttaaa tctgtcaaag cagccaaaat aatctcgcaa     5940

aatatccgag aatattttgg aaagtctttg ccagttgatc taacgtgcaa tcattttggg     6000

attgctcgta taccaagaac ggacaatgta gaattttttg atcccaatta ccgttattct     6060

ttcaaagaat ggcaagattg gtctttcaaa caaacagata ataagggctt tactcgttca     6120

agtctaacgg ttttaagcgg tacagaaggc aaaaaacaag tagatgaacc ctggtttaat     6180

ctcttattgc acgaaacgaa attttcagga gaaaagggtt tagtagggcg caatagcgtt     6240

atgtttaccc tctctttagc ctactttagt tcaggctatt caatcgaaac gtgcgaatat     6300

aatatgtttg agtttaataa tcgattagat caacccttag aagaaaaaga agtaatcaaa     6360

attgttagaa gtgcctattc agaaaactat caaggggcta atagggaata cattaccatt     6420

ctttgcaaag cttgggtatc aagtgattta accagtaaag atttatttgt ccgtcaaggg     6480

tggtttaaat tcaagaaaaa aagaagcgaa cgtcaacgtg ttcatttgtc agaatggaaa     6540

gaagatttaa tggcttatat tagcgaaaaa agcgatgtat acaagcctta tttagcgacg     6600

accaaaaaag agattagaga agtgctaggc attcctgaac ggacattaga taaattgctg     6660

aaggtactga aggcgaatca ggaaattttc tttaagatta aaccaggaag aaatggtggc     6720

attcaacttg ctagtgttaa atcattgttg ctatcgatca ttaaattaaa aaaagaagaa     6780

cgagaaagct atataaaggc gctgacagct tcgtttaatt tagaacgtac atttattcaa     6840

gaaactctaa acaaattggc agaacgcccc aaaacggacc cacaactcga tttgtttagc     6900

tacgatacag gctgaaaata aaacccgcac tatgccatta catttatatc tatgatacgt     6960

gtttgttttt ctttgctggc tagcttaatt gcttatattt acctgcaata aaggatttct     7020

tacttccatt atactcccat tttccaaaaa catacgggga acacgggaac ttattgtaca     7080

ggccacctca tagttaatgg tttcgagcct tcctgcaatc tcatccatgg aaatatattc     7140

atccccctgc cggcctatta atgtgacttt tgtgcccggc ggatattcct gatccagctc     7200

caccataaat tggtccatgc aaattcggcc ggcaattttc aggcgttttc ccttcacaag     7260

gatgtcggtc cctttcaatt ttcggagcca gccgtccgca tagcctacag gcaccgtccc     7320

gatccatgtg tctttttccg ctgtgtactc ggctccgtag ctgacgctct cgccttttct     7380

gatcagtttg acatgtgaca gtgtcgaatg cagggtaaat gccggacgca gctgaaacgg     7440

tatctcgtcc gacatgtcag cagacgggcg aaggccatac atgccgatgc cgaatctgac     7500

tgcattaaaa aagccttttt tcagccggag tccagcggcg ctgttcgcgc agtggaccat     7560

tagattcttt aacggcagcg gagcaatcag ctctttaaag cgctcaaact gcattaagaa     7620

atagcctctt tctttttcat ccgctgtcgc aaaatgggta aatacccctt tgcactttaa     7680

acgagggttg cggtcaagaa ttgccatcac gttctgaact tcttcctctg tttttacacc     7740

aagtctgttc atccccgtat cgaccttcag atgaaaatga agagaacctt ttttcgtgtg     7800

gcgggctgcc tcctgaagcc attcaacaga ataacctgtt aaggtcacgt catactcagc     7860

agcgattgcc acatactccg ggggaaccgc gccaagcacc aatataggcg ccttcaatcc     7920

ctttttgcgc agtgaaatcg cttcatccaa aatggccacg gccaagcatg aagcacctgc     7980

gtcaagagca gcctttgctg tttctgcatc accatgcccg taggcgtttg ctttcacaac     8040

tgccatcaag tggacatgtt caccgatatg ttttttcata ttgctgacat tttcctttat     8100

cacggacaag tcaatttccg cccacgtatc tctgtaaaaa ggttttgtgc tcatggaaaa     8160

ctcctctctt ttttcagaaa atcccagtac gtaattaagt atttgagaat taattttata     8220

ttgattaata ctaagtttac ccagttttca cctaaaaaac aaatgatgag ataatagctc     8280

caaaggctaa agaggactat accaactatt tgttaat                              8317


<210>  12
<211>  32
<212>  PRT
<213>  Listeria monocytogenes

<400>  12

Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala 
1               5                   10                  15      


Ser Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys 
            20                  25                  30          


<210>  13
<211>  19
<212>  PRT
<213>  Listeria monocytogenes

<400>  13

Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala 
1               5                   10                  15      


Ser Pro Lys 
            


<210>  14
<211>  14
<212>  PRT
<213>  Listeria monocytogenes

<400>  14

Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg 
1               5                   10                  


<210>  15
<211>  28
<212>  PRT
<213>  Listeria monocytogenes

<400>  15

Lys Ala Ser Val Thr Asp Thr Ser Glu Gly Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  16
<211>  20
<212>  PRT
<213>  Listeria monocytogenes

<400>  16

Lys Asn Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  17
<211>  33
<212>  PRT
<213>  Listeria monocytogenes

<400>  17

Arg Gly Gly Ile Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  18
<211>  19
<212>  PRT
<213>  Listeria seeligeri

<400>  18

Arg Ser Glu Val Thr Ile Ser Pro Ala Glu Thr Pro Glu Ser Pro Pro 
1               5                   10                  15      


Ala Thr Pro 
            


<210>  19
<211>  17
<212>  PRT
<213>  Streptococcus pyogenes

<400>  19

Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  20
<211>  17
<212>  PRT
<213>  Streptococcus equisimilis

<400>  20

Lys Gln Asn Thr Ala Asn Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  21
<211>  441
<212>  PRT
<213>  Listeria monocytogenes

<400>  21

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp 
        435                 440     


<210>  22
<211>  416
<212>  PRT
<213>  Listeria monocytogenes

<400>  22

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


<210>  23
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  23

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  24
<211>  416
<212>  PRT
<213>  Listeria monocytogenes

<400>  24

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


<210>  25
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding chimeric HER-2 protein

<400>  25
acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg       60

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      120

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      180

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      240

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      300

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      360

ctctgctacc aggacacgat tttgtggaag aatatccagg agtttgctgg ctgcaagaag      420

atctttggga gcctggcatt tctgccggag agctttgatg gggacccagc ctccaacact      480

gccccgctcc agccagagca gctccaagtg tttgagactc tggaagagat cacaggttac      540

ctatacatct cagcatggcc ggacagcctg cctgacctca gcgtcttcca gaacctgcaa      600

gtaatccggg gacgaattct gcacaatggc gcctactcgc tgaccctgca agggctgggc      660

atcagctggc tggggctgcg ctcactgagg gaactgggca gtggactggc cctcatccac      720

cataacaccc acctctgctt cgtgcacacg gtgccctggg accagctctt tcggaacccg      780

caccaagctc tgctccacac tgccaaccgg ccagaggacg agtgtgtggg cgagggcctg      840

gcctgccacc agctgtgcgc ccgagggcag cagaagatcc ggaagtacac gatgcggaga      900

ctgctgcagg aaacggagct ggtggagccg ctgacaccta gcggagcgat gcccaaccag      960

gcgcagatgc ggatcctgaa agagacggag ctgaggaagg tgaaggtgct tggatctggc     1020

gcttttggca cagtctacaa gggcatctgg atccctgatg gggagaatgt gaaaattcca     1080

gtggccatca aagtgttgag ggaaaacaca tcccccaaag ccaacaaaga aatcttagac     1140

gaagcatacg tgatggctgg tgtgggctcc ccatatgtct cccgccttct gggcatctgc     1200

ctgacatcca cggtgcagct ggtgacacag cttatgccct atggctgcct cttagactaa     1260


<210>  26
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric HER-2 protein

<400>  26

Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   10                  15      


Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser 
            20                  25                  30          


Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His 
        35                  40                  45              


Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly 
    50                  55                  60                  


Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly 
65                  70                  75                  80  


Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly 
                85                  90                  95      


Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly 
            100                 105                 110         


Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu 
        115                 120                 125             


Trp Lys Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser 
    130                 135                 140                 


Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr 
145                 150                 155                 160 


Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu 
                165                 170                 175     


Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp 
            180                 185                 190         


Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His 
        195                 200                 205             


Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu 
    210                 215                 220                 


Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 
225                 230                 235                 240 


His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu 
                245                 250                 255     


Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu 
            260                 265                 270         


Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg 
        275                 280                 285             


Gly Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln Glu 
    290                 295                 300                 


Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn Gln 
305                 310                 315                 320 


Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys Val 
                325                 330                 335     


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile Pro 
            340                 345                 350         


Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg Glu 
        355                 360                 365             


Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
    370                 375                 380                 


Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile Cys 
385                 390                 395                 400 


Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly Cys 
                405                 410                 415     


Leu Leu Asp 
            


<210>  27
<211>  3716
<212>  DNA
<213>  Homo sapiens

<400>  27
ccggaatcgc gggcacccaa gtgtgtaccg gcacagacat gaagttgcgg ctccctgcca       60

gtcctgagac ccacctggac atgctccgcc acctgtacca gggctgtcag gtagtgcagg      120

gcaacttgga gcttacctac gtgcctgcca atgccagcct ctcattcctg caggacatcc      180

aggaagttca gggttacatg ctcatcgctc acaaccaggt gaagcgcgtc ccactgcaaa      240

ggctgcgcat cgtgagaggg acccagctct ttgaggacaa gtatgccctg gctgtgctag      300

acaaccgaga tcctcaggac aatgtcgccg cctccacccc aggcagaacc ccagaggggc      360

tgcgggagct gcagcttcga agtctcacag agatcctgaa gggaggagtt ttgatccgtg      420

ggaaccctca gctctgctac caggacatgg ttttgtggaa ggacgtcttc cgcaagaata      480

accaactggc tcctgtcgat atagacacca atcgttcccg ggcctgtcca ccttgtgccc      540

ccgcctgcaa agacaatcac tgttggggtg agagtccgga agactgtcag atcttgactg      600

gcaccatctg taccagtggt tgtgcccggt gcaagggccg gctgcccact gactgctgcc      660

atgagcagtg tgccgcaggc tgcacgggcc ccaagcattc tgactgcctg gcctgcctcc      720

acttcaatca tagtggtatc tgtgagctgc actgcccagc cctcgtcacc tacaacacag      780

acacctttga gtccatgcac aaccctgagg gtcgctacac ctttggtgcc agctgcgtga      840

ccacctgccc ctacaactac ctgtctacgg aagtgggatc ctgcactctg gtgtgtcccc      900

cgaataacca agaggtcaca gctgaggacg gaacacagcg ttgtgagaaa tgcagcaagc      960

cctgtgctcg agtgtgctat ggtctgggca tggagcacct tcgaggggcg agggccatca     1020

ccagtgacaa tgtccaggag tttgatggct gcaagaagat ctttgggagc ctggcatttt     1080

tgccggagag ctttgatggg gacccctcct ccggcattgc tccgctgagg cctgagcagc     1140

tccaagtgtt cgaaaccctg gaggagatca caggttacct gtacatctca gcatggccag     1200

acagtctccg tgacctcagt gtcttccaga accttcgaat cattcgggga cggattctcc     1260

acgatggcgc gtactcattg acactgcaag gcctggggat ccactcgctg gggctgcgct     1320

cactgcggga gctgggcagt ggattggctc tgattcaccg caacgcccat ctctgctttg     1380

tacacactgt accttgggac cagctcttcc ggaacccaca tcaggccctg ctccacagtg     1440

ggaaccggcc ggaagaggat tgtggtctcg agggcttggt ctgtaactca ctgtgtgccc     1500

acgggcactg ctgggggcca gggcccaccc agtgtgtcaa ctgcagtcat ttccttcggg     1560

gccaggagtg tgtggaggag tgccgagtat ggaaggggct cccccgggag tatgtgagtg     1620

acaagcgctg tctgccgtgt caccccgagt gtcagcctca aaacagctca gagacctgct     1680

ttggatcgga ggctgatcag tgtgcagcct gcgcccacta caaggactcg tcctcctgtg     1740

tggctcgctg ccccagtggt gtgaaaccgg acctctccta catgcccatc tggaagtacc     1800

cggatgagga gggcatatgc cagccgtgcc ccatcaactg cacccactcc tgtgtggatc     1860

tggatgaacg aggctgccca gcagagcaga gagccagccc ggtgacattc atcattgcaa     1920

ctgtagtggg cgtcctgctg ttcctgatct tagtggtggt cgttggaatc ctaatcaaac     1980

gaaggagaca gaagatccgg aagtatacga tgcgtaggct gctgcaggaa actgagttag     2040

tggagccgct gacgcccagc ggagcaatgc ccaaccaggc tcagatgcgg atcctaaaag     2100

agacggagct aaggaaggtg aaggtgcttg gatcaggagc ttttggcact gtctacaagg     2160

gcatctggat cccagatggg gagaatgtga aaatccccgt ggctatcaag gtgttgagag     2220

aaaacacatc tcctaaagcc aacaaagaaa ttctagatga agcgtatgtg atggctggtg     2280

tgggttctcc gtatgtgtcc cgcctcctgg gcatctgcct gacatccaca gtacagctgg     2340

tgacacagct tatgccctac ggctgccttc tggaccatgt ccgagaacac cgaggtcgcc     2400

taggctccca ggacctgctc aactggtgtg ttcagattgc caaggggatg agctacctgg     2460

aggacgtgcg gcttgtacac agggacctgg ctgcccggaa tgtgctagtc aagagtccca     2520

accacgtcaa gattacagat ttcgggctgg ctcggctgct ggacattgat gagacagagt     2580

accatgcaga tgggggcaag gtgcccatca aatggatggc attggaatct attctcagac     2640

gccggttcac ccatcagagt gatgtgtgga gctatggagt gactgtgtgg gagctgatga     2700

cttttggggc caaaccttac gatggaatcc cagcccggga gatccctgat ttgctggaga     2760

agggagaacg cctacctcag cctccaatct gcaccattga tgtctacatg attatggtca     2820

aatgttggat gattgactct gaatgtcgcc cgagattccg ggagttggtg tcagaatttt     2880

cacgtatggc gagggacccc cagcgttttg tggtcatcca gaacgaggac ttgggcccat     2940

ccagccccat ggacagtacc ttctaccgtt cactgctgga agatgatgac atgggtgacc     3000

tggtagacgc tgaagagtat ctggtgcccc agcagggatt cttctccccg gaccctaccc     3060

caggcactgg gagcacagcc catagaaggc accgcagctc gtccaccagg agtggaggtg     3120

gtgagctgac actgggcctg gagccctcgg aagaagggcc ccccagatct ccactggctc     3180

cctcggaagg ggctggctcc gatgtgtttg atggtgacct ggcaatgggg gtaaccaaag     3240

ggctgcagag cctctctcca catgacctca gccctctaca gcggtacagc gaggacccca     3300

cattacctct gccccccgag actgatggct atgttgctcc cctggcctgc agcccccagc     3360

ccgagtatgt gaaccaatca gaggttcagc ctcagcctcc tttaacccca gagggtcctc     3420

tgcctcctgt ccggcctgct ggtgctactc tagaaagacc caagactctc tctcctggga     3480

agaatggggt tgtcaaagac gtttttgcct tcgggggtgc tgtggagaac cctgaatact     3540

tagtaccgag agaaggcact gcctctccgc cccacccttc tcctgccttc agcccagcct     3600

ttgacaacct ctattactgg gaccagaact catcggagca ggggcctcca ccaagtaact     3660

ttgaagggac ccccactgca gagaaccctg agtacctagg cctggatgta cctgta         3716


<210>  28
<211>  360
<212>  DNA
<213>  Rattus norvegicus

<400>  28
cccaggcaga accccagagg ggctgcggga gctgcagctt cgaagtctca cagagatcct       60

gaagggagga gttttgatcc gtgggaaccc tcagctctgc taccaggaca tggttttgtg      120

gaaggacgtc ttccgcaaga ataaccaact ggctcctgtc gatatagaca ccaatcgttc      180

ccgggcctgt ccaccttgtg cccccgcctg caaagacaat cactgttggg gtgagagtcc      240

ggaagactgt cagatcttga ctggcaccat ctgtaccagt ggttgtgccc ggtgcaaggg      300

ccggctgccc actgactgct gccatgagca gtgtgccgca ggctgcacgg gccccaagca      360


<210>  29
<211>  618
<212>  DNA
<213>  Rattus norvegicus

<400>  29
ggtcacagct gaggacggaa cacagcgttg tgagaaatgc agcaagccct gtgctcgagt       60

gtgctatggt ctgggcatgg agcaccttcg aggggcgagg gccatcacca gtgacaatgt      120

ccaggagttt gatggctgca agaagatctt tgggagcctg gcatttttgc cggagagctt      180

tgatggggac ccctcctccg gcattgctcc gctgaggcct gagcagctcc aagtgttcga      240

aaccctggag gagatcacag gttacctgta catctcagca tggccagaca gtctccgtga      300

cctcagtgtc ttccagaacc ttcgaatcat tcggggacgg attctccacg atggcgcgta      360

ctcattgaca ctgcaaggcc tggggatcca ctcgctgggg ctgcgctcac tgcgggagct      420

gggcagtgga ttggctctga ttcaccgcaa cgcccatctc tgctttgtac acactgtacc      480

ttgggaccag ctcttccgga acccacatca ggccctgctc cacagtggga accggccgga      540

agaggattgt ggtctcgagg gcttggtctg taactcactg tgtgcccacg ggcactgctg      600

ggggccaggg cccaccca                                                    618


<210>  30
<211>  929
<212>  DNA
<213>  Rattus norvegicus

<400>  30
cgcccagcgg agcaatgccc aaccaggctc agatgcggat cctaaaagag acggagctaa       60

ggaaggtgaa ggtgcttgga tcaggagctt ttggcactgt ctacaagggc atctggatcc      120

cagatgggga gaatgtgaaa atccccgtgg ctatcaaggt gttgagagaa aacacatctc      180

ctaaagccaa caaagaaatt ctagatgaag cgtatgtgat ggctggtgtg ggttctccgt      240

atgtgtcccg cctcctgggc atctgcctga catccacagt acagctggtg acacagctta      300

tgccctacgg ctgccttctg gaccatgtcc gagaacaccg aggtcgccta ggctcccagg      360

acctgctcaa ctggtgtgtt cagattgcca aggggatgag ctacctggag gacgtgcggc      420

ttgtacacag ggacctggct gcccggaatg tgctagtcaa gagtcccaac cacgtcaaga      480

ttacagattt cgggctggct cggctgctgg acattgatga gacagagtac catgcagatg      540

ggggcaaggt gcccatcaaa tggatggcat tggaatctat tctcagacgc cggttcaccc      600

atcagagtga tgtgtggagc tatggagtga ctgtgtggga gctgatgact tttggggcca      660

aaccttacga tggaatccca gcccgggaga tccctgattt gctggagaag ggagaacgcc      720

tacctcagcc tccaatctgc accattgatg tctacatgat tatggtcaaa tgttggatga      780

ttgactctga atgtcgcccg agattccggg agttggtgtc agaattttca cgtatggcga      840

gggaccccca gcgttttgtg gtcatccaga acgaggactt gggcccatcc agccccatgg      900

acagtacctt ctaccgttca ctgctggaa                                        929


<210>  31
<211>  3798
<212>  DNA
<213>  Homo sapiens

<400>  31
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcgtctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gcggagactg ctgcaggaaa cggagctggt ggagccgctg     2100

acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga gacggagctg     2160

aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg catctggatc     2220

cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc     2280

cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggctggtgt gggctcccca     2340

tatgtctccc gccttctggg catctgcctg acatccacgg tgcagctggt gacacagctt     2400

atgccctatg gctgcctctt agaccatgtc cgggaaaacc gcggacgcct gggctcccag     2460

gacctgctga actggtgtat gcagattgcc aaggggatga gctacctgga ggatgtgcgg     2520

ctcgtacaca gggacttggc cgctcggaac gtgctggtca agagtcccaa ccatgtcaaa     2580

attacagact tcgggctggc tcggctgctg gacattgacg agacagagta ccatgcagat     2640

gggggcaagg tgcccatcaa gtggatggcg ctggagtcca ttctccgccg gcggttcacc     2700

caccagagtg atgtgtggag ttatggtgtg actgtgtggg agctgatgac ttttggggcc     2760

aaaccttacg atgggatccc agcccgggag atccctgacc tgctggaaaa gggggagcgg     2820

ctgccccagc cccccatctg caccattgat gtctacatga tcatggtcaa atgttggatg     2880

attgactctg aatgtcggcc aagattccgg gagttggtgt ctgaattctc ccgcatggcc     2940

agggaccccc agcgctttgt ggtcatccag aatgaggact tgggcccagc cagtcccttg     3000

gacagcacct tctaccgctc actgctggag gacgatgaca tgggggacct ggtggatgct     3060

gaggagtatc tggtacccca gcagggcttc ttctgtccag accctgcccc gggcgctggg     3120

ggcatggtcc accacaggca ccgcagctca tctaccagga gtggcggtgg ggacctgaca     3180

ctagggctgg agccctctga agaggaggcc cccaggtctc cactggcacc ctccgaaggg     3240

gctggctccg atgtatttga tggtgacctg ggaatggggg cagccaaggg gctgcaaagc     3300

ctccccacac atgaccccag ccctctacag cggtacagtg aggaccccac agtacccctg     3360

ccctctgaga ctgatggcta cgttgccccc ctgacctgca gcccccagcc tgaatatgtg     3420

aaccagccag atgttcggcc ccagccccct tcgccccgag agggccctct gcctgctgcc     3480

cgacctgctg gtgccactct ggaaagggcc aagactctct ccccagggaa gaatggggtc     3540

gtcaaagacg tttttgcctt tgggggtgcc gtggagaacc ccgagtactt gacaccccag     3600

ggaggagctg cccctcagcc ccaccctcct cctgccttca gcccagcctt cgacaacctc     3660

tattactggg accaggaccc accagagcgg ggggctccac ccagcacctt caaagggaca     3720

cctacggcag agaacccaga gtacctgggt ctggacgtgc cagtgtgaac cagaaggcca     3780

agtccgcaga agccctga                                                   3798


<210>  32
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  32
gagacccacc tggacatgct ccgccacctc taccagggct gccaggtggt gcagggaaac       60

ctggaactca cctacctgcc caccaatgcc agcctgtcct tcctgcagga tatccaggag      120

gtgcagggct acgtgctcat cgctcacaac caagtgaggc aggtcccact gcagaggctg      180

cggattgtgc gaggcaccca gctctttgag gacaactatg ccctggccgt gctagacaat      240

ggagacccgc tgaacaatac cacccctgtc acaggggcct ccccaggagg cctgcgggag      300

ctgcagcttc gaagcctcac agagatcttg aaaggagggg tcttgatcca gcggaacccc      360

cagctctgct accaggacac gattttgtgg aag                                   393


<210>  33
<211>  921
<212>  DNA
<213>  Homo sapiens

<400>  33
gccgcgagca cccaagtgtg caccggcaca gacatgaagc tgcggctccc tgccagtccc       60

gagacccacc tggacatgct ccgccacctc taccagggct gccaggtggt gcagggaaac      120

ctggaactca cctacctgcc caccaatgcc agcctgtcct tcctgcagga tatccaggag      180

gtgcagggct acgtgctcat cgctcacaac caagtgaggc aggtcccact gcagaggctg      240

cggattgtgc gaggcaccca gctctttgag gacaactatg ccctggccgt gctagacaat      300

ggagacccgc tgaacaatac cacccctgtc acaggggcct ccccaggagg cctgcgggag      360

ctgcagcttc gaagcctcac agagatcttg aaaggagggg tcttgatcca gcggaacccc      420

cagctctgct accaggacac gattttgtgg aaggacatct tccacaagaa caaccagctg      480

gctctcacac tgatagacac caaccgctct cgggcctgcc acccctgttc tccgatgtgt      540

aagggctccc gctgctgggg agagagttct gaggattgtc agagcctgac gcgcactgtc      600

tgtgccggtg gctgtgcccg ctgcaagggg ccactgccca ctgactgctg ccatgagcag      660

tgtgctgccg gctgcacggg ccccaagcac tctgactgcc tggcctgcct ccacttcaac      720

cacagtggca tctgtgagct gcactgccca gccctggtca cctacaacac agacacgttt      780

gagtccatgc ccaatcccga gggccggtat acattcggcg ccagctgtgt gactgcctgt      840

ccctacaact acctttctac ggacgtggga tcctgcaccc tcgtctgccc cctgcacaac      900

caagaggtga cagcagagga t                                                921


<210>  34
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  34
aatatccagg agtttgctgg ctgcaagaag atctttggga gcctggcatt tctgccggag       60

agctttgatg gggacccagc ctccaacact gccccgctcc agccagagca gctccaagtg      120

tttgagactc tggaagagat cacaggttac ctatacatct cagcatggcc ggacagcctg      180

cctgacctca gcgtcttcca gaacctgcaa gtaatccggg gacgaattct gcacaatggc      240

gcctactcgc tgaccctgca agggctgggc atcagctggc tggggctgcg ctcactgagg      300

gaactgggca gtggactggc cctcatccac cataacaccc acctctgctt cgtgcacacg      360

gtgccctggg accagctctt tcggaacccg caccaagctc tgctccacac tgccaaccgg      420

ccagaggacg agtgtgtggg cgagggcctg gcctgccacc agctgtgcgc ccgaggg         477


<210>  35
<211>  597
<212>  DNA
<213>  Homo sapiens

<400>  35
tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg       60

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc      120

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag      180

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat      240

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact      300

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc      360

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg      420

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc      480

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg      540

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagag         597


<210>  36
<211>  391
<212>  DNA
<213>  Homo sapiens

<400>  36
cagcagaaga tccggaagta cacgatgcgg agactgctgc aggaaacgga gctggtggag       60

ccgctgacac ctagcggagc gatgcccaac caggcgcaga tgcggatcct gaaagagacg      120

gagctgagga aggtgaaggt gcttggatct ggcgcttttg gcacagtcta caagggcatc      180

tggatccctg atggggagaa tgtgaaaatt ccagtggcca tcaaagtgtt gagggaaaac      240

acatccccca aagccaacaa agaaatctta gacgaagcat acgtgatggc tggtgtgggc      300

tccccatatg tctcccgcct tctgggcatc tgcctgacat ccacggtgca gctggtgaca      360

cagcttatgc cctatggctg cctcttagac t                                     391


<210>  37
<211>  1209
<212>  DNA
<213>  Homo sapiens

<400>  37
cagcagaaga tccggaagta cacgatgcgg agactgctgc aggaaacgga gctggtggag       60

ccgctgacac ctagcggagc gatgcccaac caggcgcaga tgcggatcct gaaagagacg      120

gagctgagga aggtgaaggt gcttggatct ggcgcttttg gcacagtcta caagggcatc      180

tggatccctg atggggagaa tgtgaaaatt ccagtggcca tcaaagtgtt gagggaaaac      240

acatccccca aagccaacaa agaaatctta gacgaagcat acgtgatggc tggtgtgggc      300

tccccatatg tctcccgcct tctgggcatc tgcctgacat ccacggtgca gctggtgaca      360

cagcttatgc cctatggctg cctcttagac catgtccggg aaaaccgcgg acgcctgggc      420

tcccaggacc tgctgaactg gtgtatgcag attgccaagg ggatgagcta cctggaggat      480

gtgcggctcg tacacaggga cttggccgct cggaacgtgc tggtcaagag tcccaaccat      540

gtcaaaatta cagacttcgg gctggctcgg ctgctggaca ttgacgagac agagtaccat      600

gcagatgggg gcaaggtgcc catcaagtgg atggcgctgg agtccattct ccgccggcgg      660

ttcacccacc agagtgatgt gtggagttat ggtgtgactg tgtgggagct gatgactttt      720

ggggccaaac cttacgatgg gatcccagcc cgggagatcc ctgacctgct ggaaaagggg      780

gagcggctgc cccagccccc catctgcacc attgatgtct acatgatcat ggtcaaatgt      840

tggatgattg actctgaatg tcggccaaga ttccgggagt tggtgtctga attctcccgc      900

atggccaggg acccccagcg ctttgtggtc atccagaatg aggacttggg cccagccagt      960

cccttggaca gcaccttcta ccgctcactg ctggaggacg atgacatggg ggacctggtg     1020

gatgctgagg agtatctggt accccagcag ggcttcttct gtccagaccc tgccccgggc     1080

gctgggggca tggtccacca caggcaccgc agctcatcta ccaggagtgg cggtggggac     1140

ctgacactag ggctggagcc ctctgaagag gaggccccca ggtctccact ggcaccctcc     1200

gaaggggct                                                             1209


<210>  38
<211>  1158
<212>  DNA
<213>  Homo sapiens

<400>  38
cagaggttgc cccggatgca ggaggattcc cccttgggag gaggctcttc tggggaagat       60

gacccactgg gcgaggagga tctgcccagt gaagaggatt cacccagaga ggaggatcca      120

cccggagagg aggatctacc tggagaggag gatctacctg gagaggagga tctacctgaa      180

gttaagccta aatcagaaga agagggctcc ctgaagttag aggatctacc tactgttgag      240

gctcctggag atcctcaaga accccagaat aatgcccaca gggacaaaga aggggatgac      300

cagagtcatt ggcgctatgg aggcgacccg ccctggcccc gggtgtcccc agcctgcgcg      360

ggccgcttcc agtccccggt ggatatccgc ccccagctcg ccgccttctg cccggccctg      420

cgccccctgg aactcctggg cttccagctc ccgccgctcc cagaactgcg cctgcgcaac      480

aatggccaca gtgtgcaact gaccctgcct cctgggctag agatggctct gggtcccggg      540

cgggagtacc gggctctgca gctgcatctg cactgggggg ctgcaggtcg tccgggctcg      600

gagcacactg tggaaggcca ccgtttccct gccgagatcc acgtggttca cctcagcacc      660

gcctttgcca gagttgacga ggccttgggg cgcccgggag gcctggccgt gttggccgcc      720

tttctggagg agggcccgga agaaaacagt gcctatgagc agttgctgtc tcgcttggaa      780

gaaatcgctg aggaaggctc agagactcag gtcccaggac tggacatatc tgcactcctg      840

ccctctgact tcagccgcta cttccaatat gaggggtctc tgactacacc gccctgtgcc      900

cagggtgtca tctggactgt gtttaaccag acagtgatgc tgagtgctaa gcagctccac      960

accctctctg acaccctgtg gggacctggt gactctcggc tacagctgaa cttccgagcg     1020

acgcagcctt tgaatgggcg agtgattgag gcctccttcc ctgctggagt ggacagcagt     1080

cctcgggctg ctgagccagt ccagctgaat tcctgcctgg ctgctggtga catcctagcc     1140

ctggtttttg gcctcctt                                                   1158


<210>  39
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro Leu Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp Leu Pro Ser Glu Glu 
            20                  25                  30          


Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu Glu Asp Leu Pro Gly 
        35                  40                  45              


Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Glu Val Lys Pro Lys 
    50                  55                  60                  


Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp Leu Pro Thr Val Glu 
65                  70                  75                  80  


Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn Ala His Arg Asp Lys 
                85                  90                  95      


Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly Gly Asp Pro Pro Trp 
            100                 105                 110         


Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe Gln Ser Pro Val Asp 
        115                 120                 125             


Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala Leu Arg Pro Leu Glu 
    130                 135                 140                 


Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu Leu Arg Leu Arg Asn 
145                 150                 155                 160 


Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro Gly Leu Glu Met Ala 
                165                 170                 175     


Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln Leu His Leu His Trp 
            180                 185                 190         


Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr Val Glu Gly His Arg 
        195                 200                 205             


Phe Pro Ala Glu Ile His Val Val His Leu Ser Thr Ala Phe Ala Arg 
    210                 215                 220                 


Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu Ala Val Leu Ala Ala 
225                 230                 235                 240 


Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala Tyr Glu Gln Leu Leu 
                245                 250                 255     


Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser Glu Thr Gln Val Pro 
            260                 265                 270         


Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp Phe Ser Arg Tyr Phe 
        275                 280                 285             


Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys Ala Gln Gly Val Ile 
    290                 295                 300                 


Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser Ala Lys Gln Leu His 
305                 310                 315                 320 


Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp Ser Arg Leu Gln Leu 
                325                 330                 335     


Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg Val Ile Glu Ala Ser 
            340                 345                 350         


Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala Ala Glu Pro Val Gln 
        355                 360                 365             


Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu Ala Leu Val Phe Gly 
    370                 375                 380                 


Leu Leu 
385     


<210>  40
<211>  2487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding tLLO-CA9

<400>  40
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatctcgagc agaggttgcc ccggatgcag gaggattccc ccttgggagg aggctcttct     1380

ggggaagatg acccactggg cgaggaggat ctgcccagtg aagaggattc acccagagag     1440

gaggatccac ccggagagga ggatctacct ggagaggagg atctacctgg agaggaggat     1500

ctacctgaag ttaagcctaa atcagaagaa gagggctccc tgaagttaga ggatctacct     1560

actgttgagg ctcctggaga tcctcaagaa ccccagaata atgcccacag ggacaaagaa     1620

ggggatgacc agagtcattg gcgctatgga ggcgacccgc cctggccccg ggtgtcccca     1680

gcctgcgcgg gccgcttcca gtccccggtg gatatccgcc cccagctcgc cgccttctgc     1740

ccggccctgc gccccctgga actcctgggc ttccagctcc cgccgctccc agaactgcgc     1800

ctgcgcaaca atggccacag tgtgcaactg accctgcctc ctgggctaga gatggctctg     1860

ggtcccgggc gggagtaccg ggctctgcag ctgcatctgc actggggggc tgcaggtcgt     1920

ccgggctcgg agcacactgt ggaaggccac cgtttccctg ccgagatcca cgtggttcac     1980

ctcagcaccg cctttgccag agttgacgag gccttggggc gcccgggagg cctggccgtg     2040

ttggccgcct ttctggagga gggcccggaa gaaaacagtg cctatgagca gttgctgtct     2100

cgcttggaag aaatcgctga ggaaggctca gagactcagg tcccaggact ggacatatct     2160

gcactcctgc cctctgactt cagccgctac ttccaatatg aggggtctct gactacaccg     2220

ccctgtgccc agggtgtcat ctggactgtg tttaaccaga cagtgatgct gagtgctaag     2280

cagctccaca ccctctctga caccctgtgg ggacctggtg actctcggct acagctgaac     2340

ttccgagcga cgcagccttt gaatgggcga gtgattgagg cctccttccc tgctggagtg     2400

gacagcagtc ctcgggctgc tgagccagtc cagctgaatt cctgcctggc tgctggtgac     2460

atcctagccc tggtttttgg cctcctt                                         2487


<210>  41
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tLLO-CA9

<400>  41

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Leu Glu Gln Arg Leu Pro Arg 
        435                 440                 445             


Met Gln Glu Asp Ser Pro Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp 
    450                 455                 460                 


Pro Leu Gly Glu Glu Asp Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu 
465                 470                 475                 480 


Glu Asp Pro Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                485                 490                 495     


Gly Glu Glu Asp Leu Pro Glu Val Lys Pro Lys Ser Glu Glu Glu Gly 
            500                 505                 510         


Ser Leu Lys Leu Glu Asp Leu Pro Thr Val Glu Ala Pro Gly Asp Pro 
        515                 520                 525             


Gln Glu Pro Gln Asn Asn Ala His Arg Asp Lys Glu Gly Asp Asp Gln 
    530                 535                 540                 


Ser His Trp Arg Tyr Gly Gly Asp Pro Pro Trp Pro Arg Val Ser Pro 
545                 550                 555                 560 


Ala Cys Ala Gly Arg Phe Gln Ser Pro Val Asp Ile Arg Pro Gln Leu 
                565                 570                 575     


Ala Ala Phe Cys Pro Ala Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln 
            580                 585                 590         


Leu Pro Pro Leu Pro Glu Leu Arg Leu Arg Asn Asn Gly His Ser Val 
        595                 600                 605             


Gln Leu Thr Leu Pro Pro Gly Leu Glu Met Ala Leu Gly Pro Gly Arg 
    610                 615                 620                 


Glu Tyr Arg Ala Leu Gln Leu His Leu His Trp Gly Ala Ala Gly Arg 
625                 630                 635                 640 


Pro Gly Ser Glu His Thr Val Glu Gly His Arg Phe Pro Ala Glu Ile 
                645                 650                 655     


His Val Val His Leu Ser Thr Ala Phe Ala Arg Val Asp Glu Ala Leu 
            660                 665                 670         


Gly Arg Pro Gly Gly Leu Ala Val Leu Ala Ala Phe Leu Glu Glu Gly 
        675                 680                 685             


Pro Glu Glu Asn Ser Ala Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu 
    690                 695                 700                 


Ile Ala Glu Glu Gly Ser Glu Thr Gln Val Pro Gly Leu Asp Ile Ser 
705                 710                 715                 720 


Ala Leu Leu Pro Ser Asp Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser 
                725                 730                 735     


Leu Thr Thr Pro Pro Cys Ala Gln Gly Val Ile Trp Thr Val Phe Asn 
            740                 745                 750         


Gln Thr Val Met Leu Ser Ala Lys Gln Leu His Thr Leu Ser Asp Thr 
        755                 760                 765             


Leu Trp Gly Pro Gly Asp Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr 
    770                 775                 780                 


Gln Pro Leu Asn Gly Arg Val Ile Glu Ala Ser Phe Pro Ala Gly Val 
785                 790                 795                 800 


Asp Ser Ser Pro Arg Ala Ala Glu Pro Val Gln Leu Asn Ser Cys Leu 
                805                 810                 815     


Ala Ala Gly Asp Ile Leu Ala Leu Val Phe Gly Leu Leu 
            820                 825                 


<210>  42
<211>  390
<212>  PRT
<213>  Listeria monocytogenes

<400>  42

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Lys Glu Leu Glu Lys Ser Asn Lys Val Arg Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Glu Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Ile Asn Asn Asn Asn Ser Glu Gln Thr Glu Asn Ala Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Ala Asp Arg Pro Ala Ile Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Pro Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Val Asn Lys Lys Lys Val Ala Lys Glu Ser Val Ala 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Ser Pro Gln Pro Leu Lys Ala Asn Gln Gln Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Ile Arg Glu Thr Ala Ser Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Arg Gly Asp Leu Ala Ser Leu Arg Asn Ala Ile Asn Arg His Ser 
        355                 360                 365             


Gln Asn Phe Ser Asp Phe Pro Pro Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro 
385                 390 


<210>  43
<211>  1170
<212>  DNA
<213>  Listeria monocytogenes

<400>  43
atgcgtgcga tgatggtggt tttcattact gccaattgca ttacgattaa ccccgacata       60

atatttgcag cgacagatag cgaagattct agtctaaaca cagatgaatg ggaagaagaa      120

aaaacagaag agcaaccaag cgaggtaaat acgggaccaa gatacgaaac tgcacgtgaa      180

gtaagttcac gtgatattaa agaactagaa aaatcgaata aagtgagaaa tacgaacaaa      240

gcagacctaa tagcaatgtt gaaagaaaaa gcagaaaaag gtccaaatat caataataac      300

aacagtgaac aaactgagaa tgcggctata aatgaagagg cttcaggagc cgaccgacca      360

gctatacaag tggagcgtcg tcatccagga ttgccatcgg atagcgcagc ggaaattaaa      420

aaaagaagga aagccatagc atcatcggat agtgagcttg aaagccttac ttatccggat      480

aaaccaacaa aagtaaataa gaaaaaagtg gcgaaagagt cagttgcgga tgcttctgaa      540

agtgacttag attctagcat gcagtcagca gatgagtctt caccacaacc tttaaaagca      600

aaccaacaac catttttccc taaagtattt aaaaaaataa aagatgcggg gaaatgggta      660

cgtgataaaa tcgacgaaaa tcctgaagta aagaaagcga ttgttgataa aagtgcaggg      720

ttaattgacc aattattaac caaaaagaaa agtgaagagg taaatgcttc ggacttcccg      780

ccaccaccta cggatgaaga gttaagactt gctttgccag agacaccaat gcttcttggt      840

tttaatgctc ctgctacatc agaaccgagc tcattcgaat ttccaccacc acctacggat      900

gaagagttaa gacttgcttt gccagagacg ccaatgcttc ttggttttaa tgctcctgct      960

acatcggaac cgagctcgtt cgaatttcca ccgcctccaa cagaagatga actagaaatc     1020

atccgggaaa cagcatcctc gctagattct agttttacaa gaggggattt agctagtttg     1080

agaaatgcta ttaatcgcca tagtcaaaat ttctctgatt tcccaccaat cccaacagaa     1140

gaagagttga acgggagagg cggtagacca                                      1170


<210>  44
<211>  390
<212>  PRT
<213>  Listeria monocytogenes

<400>  44

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys Val Lys Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Ala Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Asn Asn Asn Asn Asn Gly Glu Gln Thr Gly Asn Val Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Val Asp Arg Pro Thr Leu Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Ser Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Ala Asn Lys Arg Lys Val Ala Lys Glu Ser Val Val 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Thr Pro Gln Pro Leu Lys Ala Asn Gln Lys Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Thr Pro Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Met Arg Glu Thr Ala Pro Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Ser Gly Asp Leu Ala Ser Leu Arg Ser Ala Ile Asn Arg His Ser 
        355                 360                 365             


Glu Asn Phe Ser Asp Phe Pro Leu Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro 
385                 390 


<210>  45
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated ActA

<400>  45

Ala Thr Asp Ser Glu Asp Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu 
1               5                   10                  15      


Glu Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr 
            20                  25                  30          


Glu Thr Ala Arg Glu Val Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys 
        35                  40                  45              


Ser Asn Lys Val Lys Asn Thr Asn Lys Ala Asp Leu Ile Ala Met Leu 
    50                  55                  60                  


Lys Ala Lys Ala Glu Lys Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu 
65                  70                  75                  80  


Gln Thr Gly Asn Val Ala Ile Asn Glu Glu Ala Ser Gly Val Asp Arg 
                85                  90                  95      


Pro Thr Leu Gln Val Glu Arg Arg His Pro Gly Leu Ser Ser Asp Ser 
            100                 105                 110         


Ala Ala Glu Ile Lys Lys Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser 
        115                 120                 125             


Glu Leu Glu Ser Leu Thr Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys 
    130                 135                 140                 


Arg Lys Val Ala Lys Glu Ser Val Val Asp Ala Ser Glu Ser Asp Leu 
145                 150                 155                 160 


Asp Ser Ser Met Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
                165                 170                 175     


Ala Asn Gln Lys Pro Phe Phe Pro Lys Val Phe Lys Lys Ile Lys Asp 
            180                 185                 190         


Ala Gly Lys Trp Val Arg Asp Lys 
        195                 200 


<210>  46
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated ActA fused to hly signal peptide - LA229

<400>  46

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Ser Arg Ala Thr Asp Ser Glu Asp 
            20                  25                  30          


Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln 
        35                  40                  45              


Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val 
    50                  55                  60                  


Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys Val Lys Asn 
65                  70                  75                  80  


Thr Asn Lys Ala Asp Leu Ile Ala Met Leu Lys Ala Lys Ala Glu Lys 
                85                  90                  95      


Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu Gln Thr Gly Asn Val Ala 
            100                 105                 110         


Ile Asn Glu Glu Ala Ser Gly Val Asp Arg Pro Thr Leu Gln Val Glu 
        115                 120                 125             


Arg Arg His Pro Gly Leu Ser Ser Asp Ser Ala Ala Glu Ile Lys Lys 
    130                 135                 140                 


Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr 
145                 150                 155                 160 


Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys Arg Lys Val Ala Lys Glu 
                165                 170                 175     


Ser Val Val Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser 
            180                 185                 190         


Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys Ala Asn Gln Lys Pro Phe 
        195                 200                 205             


Phe Pro Lys Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg 
    210                 215                 220                 


Asp Lys 
225     


<210>  47
<211>  1170
<212>  DNA
<213>  Listeria monocytogenes

<400>  47
atgcgtgcga tgatggtagt tttcattact gccaactgca ttacgattaa ccccgacata       60

atatttgcag cgacagatag cgaagattcc agtctaaaca cagatgaatg ggaagaagaa      120

aaaacagaag agcagccaag cgaggtaaat acgggaccaa gatacgaaac tgcacgtgaa      180

gtaagttcac gtgatattga ggaactagaa aaatcgaata aagtgaaaaa tacgaacaaa      240

gcagacctaa tagcaatgtt gaaagcaaaa gcagagaaag gtccgaataa caataataac      300

aacggtgagc aaacaggaaa tgtggctata aatgaagagg cttcaggagt cgaccgacca      360

actctgcaag tggagcgtcg tcatccaggt ctgtcatcgg atagcgcagc ggaaattaaa      420

aaaagaagaa aagccatagc gtcgtcggat agtgagcttg aaagccttac ttatccagat      480

aaaccaacaa aagcaaataa gagaaaagtg gcgaaagagt cagttgtgga tgcttctgaa      540

agtgacttag attctagcat gcagtcagca gacgagtcta caccacaacc tttaaaagca      600

aatcaaaaac catttttccc taaagtattt aaaaaaataa aagatgcggg gaaatgggta      660

cgtgataaaa tcgacgaaaa tcctgaagta aagaaagcga ttgttgataa aagtgcaggg      720

ttaattgacc aattattaac caaaaagaaa agtgaagagg taaatgcttc ggacttcccg      780

ccaccaccta cggatgaaga gttaagactt gctttgccag agacaccgat gcttctcggt      840

tttaatgctc ctactccatc ggaaccgagc tcattcgaat ttccgccgcc acctacggat      900

gaagagttaa gacttgcttt gccagagacg ccaatgcttc ttggttttaa tgctcctgct      960

acatcggaac cgagctcatt cgaatttcca ccgcctccaa cagaagatga actagaaatt     1020

atgcgggaaa cagcaccttc gctagattct agttttacaa gcggggattt agctagtttg     1080

agaagtgcta ttaatcgcca tagcgaaaat ttctctgatt tcccactaat cccaacagaa     1140

gaagagttga acgggagagg cggtagacca                                      1170


<210>  48
<211>  1256
<212>  DNA
<213>  Listeria monocytogenes

<400>  48
gcgccaaatc attggttgat tggtgaggat gtctgtgtgc gtgggtcgcg agatgggcga       60

ataagaagca ttaaagatcc tgacaaatat aatcaagcgg ctcatatgaa agattacgaa      120

tcgcttccac tcacagagga aggcgactgg ggcggagttc attataatag tggtatcccg      180

aataaagcag cctataatac tatcactaaa cttggaaaag aaaaaacaga acagctttat      240

tttcgcgcct taaagtacta tttaacgaaa aaatcccagt ttaccgatgc gaaaaaagcg      300

cttcaacaag cagcgaaaga tttatatggt gaagatgctt ctaaaaaagt tgctgaagct      360

tgggaagcag ttggggttaa ctgattaaca aatgttagag aaaaattaat tctccaagtg      420

atattcttaa aataattcat gaatattttt tcttatatta gctaattaag aagataacta      480

actgctaatc caatttttaa cggaacaaat tagtgaaaat gaaggccgaa ttttccttgt      540

tctaaaaagg ttgtattagc gtatcacgag gagggagtat aagtgggatt aaacagattt      600

atgcgtgcga tgatggtggt tttcattact gccaattgca ttacgattaa ccccgacgtc      660

gacccatacg acgttaattc ttgcaatgtt agctattggc gtgttctctt taggggcgtt      720

tatcaaaatt attcaattaa gaaaaaataa ttaaaaacac agaacgaaag aaaaagtgag      780

gtgaatgata tgaaattcaa aaaggtggtt ctaggtatgt gcttgatcgc aagtgttcta      840

gtctttccgg taacgataaa agcaaatgcc tgttgtgatg aatacttaca aacacccgca      900

gctccgcatg atattgacag caaattacca cataaactta gttggtccgc ggataacccg      960

acaaatactg acgtaaatac gcactattgg ctttttaaac aagcggaaaa aatactagct     1020

aaagatgtaa atcatatgcg agctaattta atgaatgaac ttaaaaaatt cgataaacaa     1080

atagctcaag gaatatatga tgcggatcat aaaaatccat attatgatac tagtacattt     1140

ttatctcatt tttataatcc tgatagagat aatacttatt tgccgggttt tgctaatgcg     1200

aaaataacag gagcaaagta tttcaatcaa tcggtgactg attaccgaga agggaa         1256


<210>  49
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gln Ser Gly Arg Gly Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  50
<211>  7011
<212>  DNA
<213>  Homo sapiens

<400>  50
atgcagtccg gccgcggccc cccacttcca gcccccggcc tggccttggc tttgaccctg       60

actatgttgg ccagacttgc atccgcggct tccttcttcg gtgagaacca cctggaggtg      120

cctgtggcca cggctctgac cgacatagac ctgcagctgc agttctccac gtcccagccc      180

gaagccctcc ttctcctggc agcaggccca gctgaccacc tcctgctgca gctctactct      240

ggacgcctgc aggtcagact tgttctgggc caggaggagc tgaggctgca gactccagca      300

gagacgctgc tgagtgactc catcccccac actgtggtgc tgactgtcgt agagggctgg      360

gccacgttgt cagtcgatgg gtttctgaac gcctcctcag cagtcccagg agccccccta      420

gaggtcccct atgggctctt tgttgggggc actgggaccc ttggcctgcc ctacctgagg      480

ggaaccagcc gacccctgag gggttgcctc catgcagcca ccctcaatgg ccgcagcctc      540

ctccggcctc tgacccccga tgtgcatgag ggctgtgctg aagagttttc tgccagtgat      600

gatgtggccc tgggcttctc tgggccccac tctctggctg ccttccctgc ctggggcact      660

caggacgaag gaaccctaga gtttacactc accacacaga gccggcaggc acccttggcc      720

ttccaggcag ggggccggcg tggggacttc atctatgtgg acatatttga gggccacctg      780

cgggccgtgg tggagaaggg ccagggtacc gtattgctcc acaacagtgt gcctgtggcc      840

gatgggcagc cccatgaggt cagtgtccac atcaatgctc accggctgga aatctccgtg      900

gaccagtacc ctacgcatac ttcgaaccga ggagtcctca gctacctgga gccacggggc      960

agtctccttc tcggggggct ggatgcagag gcctctcgtc acctccagga acaccgcctg     1020

ggcctgacac cagaggccac caatgcctcc ctgctgggct gcatggaaga cctcagtgtc     1080

aatggccaga ggcgggggct gcgggaagct ttgctgacgc gcaacatggc agccggctgc     1140

aggctggagg aggaggagta tgaggacgat gcctatggac attatgaagc tttctccacc     1200

ctggcccctg aggcttggcc agccatggag ctgcctgagc catgcgtgcc tgagccaggg     1260

ctgcctcctg tctttgccaa tttcacccag ctgctgacta tcagcccact ggtggtggcc     1320

gaggggggca cagcctggct tgagtggagg catgtgcagc ccacgctgga cctgatggag     1380

gctgagctgc gcaaatccca ggtgctgttc agcgtgaccc gaggggcacg ccatggcgag     1440

ctcgagctgg acatcccggg agcccaggca cgaaaaatgt tcaccctcct ggacgtggtg     1500

aaccgcaagg cccgcttcat ccacgatggc tctgaggaca cctccgacca gctggtgctg     1560

gaggtgtcgg tgacggctcg ggtgcccatg ccctcatgcc ttcggagggg ccaaacatac     1620

ctcctgccca tccaggtcaa ccctgtcaat gacccacccc acatcatctt cccacatggc     1680

agcctcatgg tgatcctgga acacacgcag aagccgctgg ggcctgaggt tttccaggcc     1740

tatgacccgg actctgcctg tgagggcctc accttccagg tccttggcac ctcctctggc     1800

ctccccgtgg agcgccgaga ccagcctggg gagccggcga ccgagttctc ctgccgggag     1860

ttggaggccg gcagcctagt ctatgtccac cgcggtggtc ctgcacagga cttgacgttc     1920

cgggtcagcg atggactgca ggccagcccc ccggccacgc tgaaggtggt ggccatccgg     1980

ccggccatac agatccaccg cagcacaggg ttgcgactgg cccaaggctc tgccatgccc     2040

atcttgcccg ccaacctgtc ggtggagacc aatgccgtgg ggcaggatgt gagcgtgctg     2100

ttccgcgtca ctggggccct gcagtttggg gagctgcaga agcagggggc aggtggggtg     2160

gagggtgctg agtggtgggc cacacaggcg ttccaccagc gggatgtgga gcagggccgc     2220

gtgaggtacc tgagcactga cccacagcac cacgcttacg acaccgtgga gaacctggcc     2280

ctggaggtgc aggtgggcca ggagatcctg agcaatctgt ccttcccagt gaccatccag     2340

agagccactg tgtggatgct gcggctggag ccactgcaca ctcagaacac ccagcaggag     2400

accctcacca cagcccacct ggaggccacc ctggaggagg caggcccaag ccccccaacc     2460

ttccattatg aggtggttca ggctcccagg aaaggcaacc ttcaactaca gggcacaagg     2520

ctgtcagatg gccagggctt cacccaggat gacatacagg ctggccgggt gacctatggg     2580

gccacagcac gtgcctcaga ggcagtcgag gacaccttcc gtttccgtgt cacagctcca     2640

ccatatttct ccccactcta taccttcccc atccacattg gtggtgaccc agatgcgcct     2700

gtcctcacca atgtcctcct cgtggtgcct gagggtggtg agggtgtcct ctctgctgac     2760

cacctctttg tcaagagtct caacagtgcc agctacctct atgaggtcat ggagcggccc     2820

cgccatggga ggttggcttg gcgtgggaca caggacaaga ccactatggt gacatccttc     2880

accaatgaag acctgttgcg tggccggctg gtctaccagc atgatgactc cgagaccaca     2940

gaagatgata tcccatttgt tgctacccgc cagggcgaga gcagtggtga catggcctgg     3000

gaggaggtac ggggtgtctt ccgagtggcc atccagcccg tgaatgacca cgcccctgtg     3060

cagaccatca gccggatctt ccatgtggcc cggggtgggc ggcggctgct gactacagac     3120

gacgtggcct tcagcgatgc tgactcgggc tttgctgacg cccagctggt gcttacccgc     3180

aaggacctcc tctttggcag tatcgtggcc gtagatgagc ccacgcggcc catctaccgc     3240

ttcacccagg aggacctcag gaagaggcga gtactgttcg tgcactcagg ggctgaccgt     3300

ggctggatcc agctgcaggt gtccgacggg caacaccagg ccactgcgct gctggaggtg     3360

caggcctcgg aaccctacct ccgtgtggcc aacggctcca gccttgtggt ccctcaaggg     3420

ggccagggca ccatcgacac ggccgtgctc cacctggaca ccaacctcga catccgcagt     3480

ggggatgagg tccactacca cgtcacagct ggccctcgct ggggacagct agtccgggct     3540

ggtcagccag ccacagcctt ctcccagcag gacctgctgg atggggccgt tctctatagc     3600

cacaatggca gcctcagccc ccgcgacacc atggccttct ccgtggaagc agggccagtg     3660

cacacggatg ccaccctaca agtgaccatt gccctagagg gcccactggc cccactgaag     3720

ctggtccggc acaagaagat ctacgtcttc cagggagagg cagctgagat cagaagggac     3780

cagctggagg cagcccagga ggcagtgcca cctgcagaca tcgtattctc agtgaagagc     3840

ccaccgagtg ccggctacct ggtgatggtg tcgcgtggcg ccttggcaga tgagccaccc     3900

agcctggacc ctgtgcagag cttctcccag gaggcagtgg acacaggcag ggtcctgtac     3960

ctgcactccc gccctgaggc ctggagcgat gccttctcgc tggatgtggc ctcaggcctg     4020

ggtgctcccc tcgagggcgt ccttgtggag ctggaggtgc tgcccgctgc catcccacta     4080

gaggcgcaaa acttcagcgt ccctgagggt ggcagcctca ccctggcccc tccactgctc     4140

cgtgtctccg ggccctactt ccccactctc ctgggcctca gcctgcaggt gctggagcca     4200

ccccagcatg gagccctgca gaaggaggac ggacctcaag ccaggaccct cagcgccttc     4260

tcctggagaa tggtggaaga gcagctgatc cgctacgtgc atgacgggag cgagacactg     4320

acagacagtt ttgtcctgat ggctaatgcc tccgagatgg atcgccagag ccatcctgtg     4380

gccttcactg tcactgtcct gcctgtcaat gaccaacccc ccatcctcac tacaaacaca     4440

ggcctgcaga tgtgggaggg ggccactgcg cccatccctg cggaggctct gaggagcacg     4500

gacggcgact ctgggtctga ggatctggtc tacaccatcg agcagcccag caacgggcgg     4560

gtagtgctgc ggggggcgcc gggcactgag gtgcgcagct tcacgcaggc ccagctggac     4620

ggcgggctcg tgctgttctc acacagagga accctggatg gaggcttccg cttccgcctc     4680

tctgacggcg agcacacttc ccccggacac ttcttccgag tgacggccca gaagcaagtg     4740

ctcctctcgc tgaagggcag ccagacactg actgtctgcc cagggtccgt ccagccactc     4800

agcagtcaga ccctcagggc cagctccagc gcaggcactg acccccagct cctgctctac     4860

cgtgtggtgc ggggccccca gctaggccgg ctgttccacg cccagcagga cagcacaggg     4920

gaggccctgg tgaacttcac tcaggcagag gtctacgctg ggaatattct gtatgagcat     4980

gagatgcccc ccgagccctt ttgggaggcc catgataccc tagagctcca gctgtcctcg     5040

ccgcctgccc gggacgtggc cgccaccctt gctgtggctg tgtcttttga ggctgcctgt     5100

ccccagcgcc ccagccacct ctggaagaac aaaggtctct gggtccccga gggccagcgg     5160

gccaggatca ccgtggctgc tctggatgcc tccaatctct tggccagcgt tccatcaccc     5220

cagcgctcag agcatgatgt gctcttccag gtcacacagt tccccagccg gggccagctg     5280

ttggtgtccg aggagcccct ccatgctggg cagccccact tcctgcagtc ccagctggct     5340

gcagggcagc tagtgtatgc ccacggcggt gggggcaccc agcaggatgg cttccacttt     5400

cgtgcccacc tccaggggcc agcaggggcc tccgtggctg gaccccaaac ctcagaggcc     5460

tttgccatca cggtgaggga tgtaaatgag cggccccctc agccacaggc ctctgtccca     5520

ctccggctca cccgaggctc tcgtgccccc atctcccggg cccagctgag tgtggtggac     5580

ccagactcag ctcctgggga gattgagtac gaggtccagc gggcacccca caacggcttc     5640

ctcagcctgg tgggtggtgg cctggggccc gtgacccgct tcacgcaagc cgatgtggat     5700

tcagggcggc tggccttcgt ggccaacggg agcagcgtgg caggcatctt ccagctgagc     5760

atgtctgatg gggccagccc acccctgccc atgtccctgg ctgtggacat cctaccatcc     5820

gccatcgagg tgcagctgcg ggcacccctg gaggtgcccc aagctttggg gcgctcctca     5880

ctgagccagc agcagctccg ggtggtttca gatcgggagg agccagaggc agcataccgc     5940

ctcatccagg gaccccagta tgggcatctc ctggtgggcg ggcggcccac ctcggccttc     6000

agccaattcc agatagacca gggcgaggtg gtctttgcct tcaccaactt ctcctcctct     6060

catgaccact tcagagtcct ggcactggct aggggtgtca atgcatcagc cgtagtgaac     6120

gtcactgtga gggctctgct gcatgtgtgg gcaggtgggc catggcccca gggtgccacc     6180

ctgcgcctgg accccaccgt cctagatgct ggcgagctgg ccaaccgcac aggcagtgtg     6240

ccgcgcttcc gcctcctgga gggaccccgg catggccgcg tggtccgcgt gccccgagcc     6300

aggacggagc ccgggggcag ccagctggtg gagcagttca ctcagcagga ccttgaggac     6360

gggaggctgg ggctggaggt gggcaggcca gaggggaggg cccccggccc cgcaggtgac     6420

agtctcactc tggagctgtg ggcacagggc gtcccgcctg ctgtggcctc cctggacttt     6480

gccactgagc cttacaatgc tgcccggccc tacagcgtgg ccctgctcag tgtccccgag     6540

gccgcccgga cggaagcagg gaagccagag agcagcaccc ccacaggcga gccaggcccc     6600

atggcatcca gccctgagcc cgctgtggcc aagggaggct tcctgagctt ccttgaggcc     6660

aacatgttca gcgtcatcat ccccatgtgc ctggtacttc tgctcctggc gctcatcctg     6720

cccctgctct tctacctccg aaaacgcaac aagacgggca agcatgacgt ccaggtcctg     6780

actgccaagc cccgcaacgg cctggctggt gacaccgaga cctttcgcaa ggtggagcca     6840

ggccaggcca tcccgctcac agctgtgcct ggccaggggc cccctccagg aggccagcct     6900

gacccagagc tgctgcagtt ctgccggaca cccaaccctg cccttaagaa tggccagtac     6960

tgggtgtgag gcctggcctg ggcccagatg ctgatcgggc cagggacagg c              7011


<210>  51
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  52
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  52

Ile Val Gly Gly Trp Glu Cys Glu Lys His Ser Gln Pro Trp Gln Val 
1               5                   10                  15      


Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly Gly Val Leu Val His 
            20                  25                  30          


Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg Asn Lys Ser Val 
        35                  40                  45              


Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu Asp Thr Gly Gln 
    50                  55                  60                  


Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu Tyr Asp Met Ser 
65                  70                  75                  80  


Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His Asp 
                85                  90                  95      


Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val 
            100                 105                 110         


Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys 
        115                 120                 125             


Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro 
    130                 135                 140                 


Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys 
145                 150                 155                 160 


Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly 
                165                 170                 175     


Arg Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Cys Tyr Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu 
        195                 200                 205             


Pro Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His 
    210                 215                 220                 


Tyr Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
225                 230                 235         


<210>  53
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  53

Ile Val Gly Gly Trp Glu Cys Glu Lys His Ser Gln Pro Trp Gln Val 
1               5                   10                  15      


Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly Gly Val Leu Val His 
            20                  25                  30          


Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg Asn Lys Ser Val 
        35                  40                  45              


Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu Asp Thr Gly Gln 
    50                  55                  60                  


Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu Tyr Asp Met Ser 
65                  70                  75                  80  


Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His Asp 
                85                  90                  95      


Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val 
            100                 105                 110         


Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys 
        115                 120                 125             


Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro 
    130                 135                 140                 


Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys 
145                 150                 155                 160 


Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly 
                165                 170                 175     


Arg Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu 
        195                 200                 205             


Pro Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His 
    210                 215                 220                 


Tyr Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
225                 230                 235         


<210>  54
<211>  5873
<212>  DNA
<213>  Homo sapiens

<400>  54
ggtgtcttag gcacactggt cttggagtgc aaaggatcta ggcacgtgag gctttgtatg       60

aagaatcggg gatcgtaccc accccctgtt tctgtttcat cctgggcatg tctcctctgc      120

ctttgtcccc tagatgaagt ctccatgagc tacaagggcc tggtgcatcc agggtgatct      180

agtaattgca gaacagcaag tgctagctct ccctcccctt ccacagctct gggtgtggga      240

gggggttgtc cagcctccag cagcatgggg agggccttgg tcagcctctg ggtgccagca      300

gggcaggggc ggagtcctgg ggaatgaagg ttttataggg ctcctggggg aggctcccca      360

gccccaagct taccacctgc acccggagag ctgtgtcacc atgtgggtcc cggttgtctt      420

cctcaccctg tccgtgacgt ggattggtga gaggggccat ggttgggggg atgcaggaga      480

gggagccagc cctgactgtc aagctgaggc tctttccccc ccaacccagc accccagccc      540

agacagggag ctgggctctt ttctgtctct cccagcccca cttcaagccc atacccccag      600

tcccctccat attgcaacag tcctcactcc cacaccaggt ccccgctccc tcccacttac      660

cccagaactt tcttcccatt tgcccagcca gctccctgct cccagctgct ttactaaagg      720

ggaagttcct gggcatctcc gtgtttctct ttgtggggct caaaacctcc aaggacctct      780

ctcaatgcca ttggttcctt ggaccgtatc actggtccat ctcctgagcc cctcaatcct      840

atcacagtct actgactttt cccattcagc tgtgagtgtc caaccctatc ccagagacct      900

tgatgcttgg cctcccaatc ttgccctagg atacccagat gccaaccaga cacctccttc      960

tttcctagcc aggctatctg gcctgagaca acaaatgggt ccctcagtct ggcaatggga     1020

ctctgagaac tcctcattcc ctgactctta gccccagact cttcattcag tggcccacat     1080

tttccttagg aaaaacatga gcatccccag ccacaactgc cagctctctg agtccccaaa     1140

tctgcatcct tttcaaaacc taaaaacaaa aagaaaaaca aataaaacaa aaccaactca     1200

gaccagaact gttttctcaa cctgggactt cctaaacttt ccaaaacctt cctcttccag     1260

caactgaacc tcgccataag gcacttatcc ctggttccta gcacccctta tcccctcaga     1320

atccacaact tgtaccaagt ttcccttctc ccagtccaag accccaaatc accacaaagg     1380

acccaatccc cagactcaag atatggtctg ggcgctgtct tgtgtctcct accctgatcc     1440

ctgggttcaa ctctgctccc agagcatgaa gcctctccac cagcaccagc caccaacctg     1500

caaacctagg gaagattgac agaattccca gcctttccca gctccccctg cccatgtccc     1560

aggactccca gccttggttc tctgcccccg tgtcttttca aacccacatc ctaaatccat     1620

ctcctatccg agtcccccag ttccccctgt caaccctgat tcccctgatc tagcaccccc     1680

tctgcaggcg ctgcgcccct catcctgtct cggattgtgg gaggctggga gtgcgagaag     1740

cattcccaac cctggcaggt gcttgtggcc tctcgtggca gggcagtctg cggcggtgtt     1800

ctggtgcacc cccagtgggt cctcacagct gcccactgca tcaggaagtg agtaggggcc     1860

tggggtctgg ggagcaggtg tctgtgtccc agaggaataa cagctgggca ttttccccag     1920

gataacctct aaggccagcc ttgggactgg gggagagagg gaaagttctg gttcaggtca     1980

catggggagg cagggttggg gctggaccac cctccccatg gctgcctggg tctccatctg     2040

tgtccctcta tgtctctttg tgtcgctttc attatgtctc ttggtaactg gcttcggttg     2100

tgtctctccg tgtgactatt ttgttctctc tctccctctc ttctctgtct tcagtctcca     2160

tatctccccc tctctctgtc cttctctggt ccctctctag ccagtgtgtc tcaccctgta     2220

tctctctgcc aggctctgtc tctcggtctc tgtctcacct gtgccttctc cctactgaac     2280

acacgcacgg gatgggcctg ggggaccctg agaaaaggaa gggctttggc tgggcgcggt     2340

ggctcacacc tgtaatccca gcactttggg aggccaaggc aggtagatca cctgaggtca     2400

ggagttcgag accagcctgg ccaactggtg aaaccccatc tctactaaaa atacaaaaaa     2460

ttagccaggc gtggtggcgc atgcctgtag tcccagctac tcaggagctg agggaggaga     2520

attgcattga acctggaggt tgaggttgca gtgagccgag accgtgccac tgcactccag     2580

cctgggtgac agagtgagac tccgcctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaga     2640

aaagaaaaga aaagaaaagg aagtgtttta tccctgatgt gtgtgggtat gagggtatga     2700

gagggcccct ctcactccat tccttctcca ggacatccct ccactcttgg gagacacaga     2760

gaagggctgg ttccagctgg agctgggagg ggcaattgag ggaggaggaa ggagaagggg     2820

gaaggaaaac agggtatggg ggaaaggacc ctggggagcg aagtggagga tacaaccttg     2880

ggcctgcagg caggctacct acccacttgg aaacccacgc caaagccgca tctacagctg     2940

agccactctg aggcctcccc tccccggcgg tccccactca gctccaaagt ctctctccct     3000

tttctctccc acactttatc atcccccgga ttcctctcta cttggttctc attcttcctt     3060

tgacttcctg cttccctttc tcattcatct gtttctcact ttctgcctgg ttttgttctt     3120

ctctctctct ttctctggcc catgtctgtt tctctatgtt tctgtctttt ctttctcatc     3180

ctgtgtattt tcggctcacc ttgtttgtca ctgttctccc ctctgccctt tcattctctc     3240

tgccctttta ccctcttcct tttcccttgg ttctctcagt tctgtatctg cccttcaccc     3300

tctcacactg ctgtttccca actcgttgtc tgtattttgg cctgaactgt gtcttcccaa     3360

ccctgtgttt tctcactgtt tctttttctc ttttggagcc tcctccttgc tcctctgtcc     3420

cttctctctt tccttatcat cctcgctcct cattcctgcg tctgcttcct ccccagcaaa     3480

agcgtgatct tgctgggtcg gcacagcctg tttcatcctg aagacacagg ccaggtattt     3540

caggtcagcc acagcttccc acacccgctc tacgatatga gcctcctgaa gaatcgattc     3600

ctcaggccag gtgatgactc cagccacgac ctcatgctgc tccgcctgtc agagcctgcc     3660

gagctcacgg atgctgtgaa ggtcatggac ctgcccaccc aggagccagc actggggacc     3720

acctgctacg cctcaggctg gggcagcatt gaaccagagg agtgtacgcc tgggccagat     3780

ggtgcagccg ggagcccaga tgcctgggtc tgagggagga ggggacagga ctcctgggtc     3840

tgagggagga gggccaagga accaggtggg gtccagccca caacagtgtt tttgcctggc     3900

ccgtagtctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg     3960

tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga     4020

cagggggcaa aagcacctgc tcggtgagtc atccctactc ccaagatctt gagggaaagg     4080

tgagtgggac cttaattctg ggctggggtc tagaagccaa caaggcgtct gcctcccctg     4140

ctccccagct gtagccatgc cacctccccg tgtctcatct cattccctcc ttccctcttc     4200

tttgactccc tcaaggcaat aggttattct tacagcacaa ctcatctgtt cctgcgttca     4260

gcacacggtt actaggcacc tgctatgcac ccagcactgc cctagagcct gggacatagc     4320

agtgaacaga cagagagcag cccctccctt ctgtagcccc caagccagtg aggggcacag     4380

gcaggaacag ggaccacaac acagaaaagc tggagggtgt caggaggtga tcaggctctc     4440

ggggagggag aaggggtggg gagtgtgact gggaggagac atcctgcaga aggtgggagt     4500

gagcaaacac ctgcgcaggg gaggggaggg cctgcggcac ctgggggagc agagggaaca     4560

gcatctggcc aggcctggga ggaggggcct agagggcgtc aggagcagag aggaggttgc     4620

ctggctggag tgaaggatcg gggcagggtg cgagagggaa caaaggaccc ctcctgcagg     4680

gcctcacctg ggccacagga ggacactgct tttcctctga ggagtcagga actgtggatg     4740

gtgctggaca gaagcaggac agggcctggc tcaggtgtcc agaggctgcg ctggcctcct     4800

atgggatcag actgcaggga gggagggcag cagggatgtg gagggagtga tgatggggct     4860

gacctggggg tggctccagg cattgtcccc acctgggccc ttacccagcc tccctcacag     4920

gctcctggcc ctcagtctct cccctccact ccattctcca cctacccaca gtgggtcatt     4980

ctgatcaccg aactgaccat gccagccctg ccgatggtcc tccatggctc cctagtgccc     5040

tggagaggag gtgtctagtc agagagtagt cctggaaggt ggcctctgtg aggagccacg     5100

gggacagcat cctgcagatg gtcctggccc ttgtcccacc gacctgtcta caaggactgt     5160

cctcgtggac cctcccctct gcacaggagc tggaccctga agtcccttcc taccggccag     5220

gactggagcc cctacccctc tgttggaatc cctgcccacc ttcttctgga agtcggctct     5280

ggagacattt ctctcttctt ccaaagctgg gaactgctat ctgttatctg cctgtccagg     5340

tctgaaagat aggattgccc aggcagaaac tgggactgac ctatctcact ctctccctgc     5400

ttttaccctt agggtgattc tgggggccca cttgtctgta atggtgtgct tcaaggtatc     5460

acgtcatggg gcagtgaacc atgtgccctg cccgaaaggc cttccctgta caccaaggtg     5520

gtgcattacc ggaagtggat caaggacacc atcgtggcca acccctgagc acccctatca     5580

agtccctatt gtagtaaact tggaaccttg gaaatgacca ggccaagact caagcctccc     5640

cagttctact gacctttgtc cttaggtgtg aggtccaggg ttgctaggaa aagaaatcag     5700

cagacacagg tgtagaccag agtgtttctt aaatggtgta attttgtcct ctctgtgtcc     5760

tggggaatac tggccatgcc tggagacata tcactcaatt tctctgagga cacagttagg     5820

atggggtgtc tgtgttattt gtgggataca gagatgaaag aggggtggga tcc            5873


<210>  55
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  56
<211>  1906
<212>  DNA
<213>  Homo sapiens

<400>  56
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gtgggtcatt ctgatcaccg aactgaccat gccagccctg ccgatggtcc      720

tccatggctc cctagtgccc tggagaggag gtgtctagtc agagagtagt cctggaaggt      780

ggcctctgtg aggagccacg gggacagcat cctgcagatg gtcctggccc ttgtcccacc      840

gacctgtcta caaggactgt cctcgtggac cctcccctct gcacaggagc tggaccctga      900

agtcccttcc ccaccggcca ggactggagc ccctacccct ctgttggaat ccctgcccac      960

cttcttctgg aagtcggctc tggagacatt tctctcttct tccaaagctg ggaactgcta     1020

tctgttatct gcctgtccag gtctgaaaga taggattgcc caggcagaaa ctgggactga     1080

cctatctcac tctctccctg cttttaccct tagggtgatt ctgggggccc acttgtctgt     1140

aatggtgtgc ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg     1200

ccttccctgt acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc     1260

aacccctgag cacccctatc aaccccctat tgtagtaaac ttggaacctt ggaaatgacc     1320

aggccaagac tcaagcctcc ccagttctac tgacctttgt ccttaggtgt gaggtccagg     1380

gttgctagga aaagaaatca gcagacacag gtgtagacca gagtgtttct taaatggtgt     1440

aattttgtcc tctctgtgtc ctggggaata ctggccatgc ctggagacat atcactcaat     1500

ttctctgagg acacagatag gatggggtgt ctgtgttatt tgtggggtac agagatgaaa     1560

gaggggtggg atccacactg agagagtgga gagtgacatg tgctggacac tgtccatgaa     1620

gcactgagca gaagctggag gcacaacgca ccagacactc acagcaagga tggagctgaa     1680

aacataaccc actctgtcct ggaggcactg ggaagcctag agaaggctgt gagccaagga     1740

gggagggtct tcctttggca tgggatgggg atgaagtaag gagagggact ggaccccctg     1800

gaagctgatt cactatgggg ggaggtgtat tgaagtcctc cagacaaccc tcagatttga     1860

tgatttccta gtagaactca cagaaataaa gagctgttat actgtg                    1906


<210>  57
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Lys 
65                  


<210>  58
<211>  554
<212>  DNA
<213>  Homo sapiens

<400>  58
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct tccgtgacgt ggattggtgc tgcacccctc atcctgtctc ggattgtggg      120

aggctgggag tgcgagaagc attcccaacc ctggcaggtg cttgtggcct ctcgtggcag      180

ggcagtctgc ggcggtgttc tggtgcaccc ccagtgggtc ctcacagctg cccactgcat      240

caggaagtga gtaggggcct ggggtctggg gagcaggtgt ctgtgtccca gaggaataac      300

agctgggcat tttccccagg ataacctcta aggccagcct tgggactggg ggagagaggg      360

aaagttctgg ttcaggtcac atggggaggc agggttgggg ctggaccacc ctccccatgg      420

ctgcctgggt ctccatctgt gttcctctat gtctctttgt gtcgctttca ttatgtctct      480

tggtaactgg cttcggttgt gtctctccgt gtgactattt tgttctctct ctccctctct      540

tctctgtctt cagt                                                        554


<210>  59
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys 
        115                 120                 125             


Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala 
    130                 135                 140                 


Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg 
145                 150                 155                 160 


Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu 
                165                 170                 175     


Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro 
            180                 185                 190         


Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr 
        195                 200                 205             


Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
    210                 215                 220 


<210>  60
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  60
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagcattga accagaggag ttcttgaccc      420

caaagaaact tcagtgtgtg gacctccatg ttatttccaa tgacgtgtgt gcgcaagttc      480

accctcagaa ggtgaccaag ttcatgctgt gtgctggacg ctggacaggg ggcaaaagca      540

cctgctcggg tgattctggg ggcccacttg tctgtaatgg tgtgcttcaa ggtatcacgt      600

catggggcag tgaaccatgt gccctgcccg aaaggccttc cctgtacacc aaggtggtgc      660

attaccggaa gtggatcaag gacaccatcg tggccaaccc ctgagcaccc ctatcaaccc      720

cctattgtag taaacttgga accttggaaa tgaccaggcc aagactcaag cctccccagt      780

tctactgacc tttgtcctta ggtgtgaggt ccagggttgc taggaaaaga aatcagcaga      840

cacaggtgta gaccagagtg tttcttaaat ggtgtaattt tgtcctctct gtgtcctggg      900

gaatactggc catgcctgga gacatatcac tcaatttctc tgaggacaca gataggatgg      960

ggtgtctgtg ttatttgtgg ggtacagaga tgaaagaggg gtgggatcca cactgagaga     1020

gtggagagtg acatgtgctg gacactgtcc atgaagcact gagcagaagc tggaggcaca     1080

acgcaccaga cactcacagc aaggatggag ctgaaaacat aacccactct gtcctggagg     1140

cactgggaag cctagagaag gctgtgagcc aaggagggag ggtcttcctt tggcatggga     1200

tggggatgaa gtaaggagag ggactggacc ccctggaagc tgattcacta tggggggagg     1260

tgtattgaag tcctccagac aaccctcaga tttgatgatt tcctagtaga actcacagaa     1320

ataaagagct gttatactgt g                                               1341


<210>  61
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Lys Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu 
65                  70                  75                  80  


Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met 
                85                  90                  95      


Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser 
            100                 105                 110         


Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu 
        115                 120                 125             


Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val 
    130                 135                 140                 


His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr 
145                 150                 155                 160 


Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys 
                165                 170                 175     


Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala 
            180                 185                 190         


Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys 
        195                 200                 205             


Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
    210                 215             


<210>  62
<211>  1325
<212>  DNA
<213>  Homo sapiens

<400>  62
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaagcc aggtgatgac tccagccacg acctcatgct gctccgcctg tcagagcctg      300

ccgagctcac ggatgctgtg aaggtcatgg acctgcccac ccaggagcca gcactgggga      360

ccacctgcta cgcctcaggc tggggcagca ttgaaccaga ggagttcttg accccaaaga      420

aacttcagtg tgtggacctc catgttattt ccaatgacgt gtgtgcgcaa gttcaccctc      480

agaaggtgac caagttcatg ctgtgtgctg gacgctggac agggggcaaa agcacctgct      540

cgggtgattc tgggggccca cttgtctgta atggtgtgct tcaaggtatc acgtcatggg      600

gcagtgaacc atgtgccctg cccgaaaggc cttccctgta caccaaggtg gtgcattacc      660

caaggacacc atcgtggcca acccctgagc acccctatca accccctatt gtagtaaact      720

tggaaccttg gaaatgacca ggccaagact caagcctccc cagttctact gacctttgtc      780

cttaggtgtg aggtccaggg ttgctaggaa aagaaatcag cagacacagg tgtagaccag      840

agtgtttctt aaatggtgta attttgtcct ctctgtgtcc tggggaatac tggccatgcc      900

tggagacata tcactcaatt tctctgagga cacagatagg atggggtgtc tgtgttattt      960

gtggggtaca gagatgaaag aggggtggga tccacactga gagagtggag agtgacatgt     1020

gctggacact gtccatgaag cactgagcag aagctggagg cacaacgcac cagacactca     1080

cagcaaggat ggagctgaaa acataaccca ctctgtcctg gaggcactgg gaagcctaga     1140

gaaggctgtg agccaaggag ggagggtctt cctttggcat gggatgggga tgaagtaagg     1200

agagggactg gaccccctgg aagctgattc actatggggg gaggtgtatt gaagtcctcc     1260

agacaaccct cagatttgat gatttcctag tagaactcac agaaataaag agctgttata     1320

ctgtg                                                                 1325


<210>  63
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  64
<211>  1464
<212>  DNA
<213>  Homo sapiens

<400>  64
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gggtgattct gggggcccac ttgtctgtaa tggtgtgctt caaggtatca      720

cgtcatgggg cagtgaacca tgtgccctgc ccgaaaggcc ttccctgtac accaaggtgg      780

tgcattaccg gaagtggatc aaggacacca tcgtggccaa cccctgagca cccctatcaa      840

ccccctattg tagtaaactt ggaaccttgg aaatgaccag gccaagactc aagcctcccc      900

agttctactg acctttgtcc ttaggtgtga ggtccagggt tgctaggaaa agaaatcagc      960

agacacaggt gtagaccaga gtgtttctta aatggtgtaa ttttgtcctc tctgtgtcct     1020

ggggaatact ggccatgcct ggagacatat cactcaattt ctctgaggac acagatagga     1080

tggggtgtct gtgttatttg tggggtacag agatgaaaga ggggtgggat ccacactgag     1140

agagtggaga gtgacatgtg ctggacactg tccatgaagc actgagcaga agctggaggc     1200

acaacgcacc agacactcac agcaaggatg gagctgaaaa cataacccac tctgtcctgg     1260

aggcactggg aagcctagag aaggctgtga gccaaggagg gagggtcttc ctttggcatg     1320

ggatggggat gaagtaagga gagggactgg accccctgga agctgattca ctatgggggg     1380

aggtgtattg aagtcctcca gacaaccctc agatttgatg atttcctagt agaactcaca     1440

gaaataaaga gctgttatac tgtg                                            1464


<210>  65
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  66
<211>  1495
<212>  DNA
<213>  Homo sapiens

<400>  66
gggggagccc caagcttacc acctgcaccc ggagagctgt gtcaccatgt gggtcccggt       60

tgtcttcctc accctgtccg tgacgtggat tggtgctgca cccctcatcc tgtctcggat      120

tgtgggaggc tgggagtgcg agaagcattc ccaaccctgg caggtgcttg tggcctctcg      180

tggcagggca gtctgcggcg gtgttctggt gcacccccag tgggtcctca cagctgccca      240

ctgcatcagg aacaaaagcg tgatcttgct gggtcggcac agcctgtttc atcctgaaga      300

cacaggccag gtatttcagg tcagccacag cttcccacac ccgctctacg atatgagcct      360

cctgaagaat cgattcctca ggccaggtga tgactccagc cacgacctca tgctgctccg      420

cctgtcagag cctgccgagc tcacggatgc tgtgaaggtc atggacctgc ccacccagga      480

gccagcactg gggaccacct gctacgcctc aggctggggc agcattgaac cagaggagtt      540

cttgacccca aagaaacttc agtgtgtgga cctccatgtt atttccaatg acgtgtgtgc      600

gcaagttcac cctcagaagg tgaccaagtt catgctgtgt gctggacgct ggacaggggg      660

caaaagcacc tgctcgggtg attctggggg cccacttgtc tgtaatggtg tgcttcaagg      720

tatcacgtca tggggcagtg aaccatgtgc cctgcccgaa aggccttccc tgtacaccaa      780

ggtggtgcat taccggaagt ggatcaagga caccatcgtg gccaacccct gagcacccct      840

atcaactccc tattgtagta aacttggaac cttggaaatg accaggccaa gactcaggcc      900

tccccagttc tactgacctt tgtccttagg tgtgaggtcc agggttgcta ggaaaagaaa      960

tcagcagaca caggtgtaga ccagagtgtt tcttaaatgg tgtaattttg tcctctctgt     1020

gtcctgggga atactggcca tgcctggaga catatcactc aatttctctg aggacacaga     1080

taggatgggg tgtctgtgtt atttgtgggg tacagagatg aaagaggggt gggatccaca     1140

ctgagagagt ggagagtgac atgtgctgga cactgtccat gaagcactga gcagaagctg     1200

gaggcacaac gcaccagaca ctcacagcaa ggatggagct gaaaacataa cccactctgt     1260

cctggaggca ctgggaagcc tagagaaggc tgtgagccaa ggagggaggg tcttcctttg     1320

gcatgggatg gggatgaagt agggagaggg actggacccc ctggaagctg attcactatg     1380

gggggaggtg tattgaagtc ctccagacaa ccctcagatt tgatgatttc ctagtagaac     1440

tcacagaaat aaagagctgt tatactgcga aaaaaaaaaa aaaaaaaaaa aaaaa          1495


<210>  67
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys 
        115                 120                 125             


Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala 
    130                 135                 140                 


Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg 
145                 150                 155                 160 


Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu 
                165                 170                 175     


Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro 
            180                 185                 190         


Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr 
        195                 200                 205             


Arg Lys Trp Ile Lys Asp Thr Ile Val Ala 
    210                 215             


<210>  68
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Val Ser His Pro Tyr Ser Gln Asp Leu Glu Gly Lys Gly Glu 
    210                 215                 220                 


Trp Gly Pro 
225         


<210>  69
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Glu Arg Gly His Gly Trp Gly Asp Ala Gly Glu Gly Ala Ser Pro Asp 
            20                  25                  30          


Cys Gln Ala Glu Ala Leu Ser Pro Pro Thr Gln His Pro Ser Pro Asp 
        35                  40                  45              


Arg Glu Leu Gly Ser Phe Leu Ser Leu Pro Ala Pro Leu Gln Ala His 
    50                  55                  60                  


Thr Pro Ser Pro Ser Ile Leu Gln Gln Ser Ser Leu Pro His Gln Val 
65                  70                  75                  80  


Pro Ala Pro Ser His Leu Pro Gln Asn Phe Leu Pro Ile Ala Gln Pro 
                85                  90                  95      


Ala Pro Cys Ser Gln Leu Leu Tyr 
            100                 


<210>  70
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  71
<211>  1729
<212>  DNA
<213>  Homo sapiens

<400>  71
aagtttccct tctcccagtc caagacccca aatcaccaca aaggacccaa tccccagact       60

caagatatgg tctgggcgct gtcttgtgtc tcctaccctg atccctgggt tcaactctgc      120

tcccagagca tgaagcctct ccaccagcac cagccaccaa cctgcaaacc tagggaagat      180

tgacagaatt cccagccttt cccagctccc cctgcccatg tcccaggact cccagccttg      240

gttctctgcc cccgtgtctt ttcaaaccca catcctaaat ccatctccta tccgagtccc      300

ccagttcctc ctgtcaaccc tgattcccct gatctagcac cccctctgca ggtgctgcac      360

ccctcatcct gtctcggatt gtgggaggct gggagtgcga gaagcattcc caaccctggc      420

aggtgcttgt agcctctcgt ggcagggcag tctgcggcgg tgttctggtg cacccccagt      480

gggtcctcac agctacccac tgcatcagga acaaaagcgt gatcttgctg ggtcggcaca      540

gcctgtttca tcctgaagac acaggccagg tatttcaggt cagccacagc ttcccacacc      600

cgctctacga tatgagcctc ctgaagaatc gattcctcag gccaggtgat gactccagcc      660

acgacctcat gctgctccgc ctgtcagagc ctgccgagct cacggatgct atgaaggtca      720

tggacctgcc cacccaggag ccagcactgg ggaccacctg ctacgcctca ggctggggca      780

gcattgaacc agaggagttc ttgaccccaa agaaacttca gtgtgtggac ctccatgtta      840

tttccaatga cgtgtgtgcg caagttcacc ctcagaaggt gaccaagttc atgctgtgtg      900

ctggacgctg gacagggggc aaaagcacct gctcgggtga ttctgggggc ccacttgtct      960

gtaatggtgt gcttcaaggt atcacgtcat ggggcagtga accatgtgcc ctgcccgaaa     1020

ggccttccct gtacaccaag gtggtgcatt accggaagtg gatcaaggac accatcgtgg     1080

ccaacccctg agcaccccta tcaactccct attgtagtaa acttggaacc ttggaaatga     1140

ccaggccaag actcaggcct ccccagttct actgaccttt gtccttaggt gtgaggtcca     1200

gggttgctag gaaaagaaat cagcagacac aggtgtagac cagagtgttt cttaaatggt     1260

gtaattttgt cctctctgtg tcctggggaa tactggccat gcctggagac atatcactca     1320

atttctctga ggacacagat aggatggggt gtctgtgtta tttgtggggt acagagatga     1380

aagaggggtg ggatccacac tgagagagtg gagagtgaca tgtgctggac actgtccatg     1440

aagcactgag cagaagctgg aggcacaacg caccagacac tcacagcaag gatggagctg     1500

aaaacataac ccactctgtc ctggaggcac tgggaagcct agagaaggct gtgaaccaag     1560

gagggagggt cttcctttgg catgggatgg ggatgaagta aggagaggga ctgaccccct     1620

ggaagctgat tcactatggg gggaggtgta ttgaagtcct ccagacaacc ctcagatttg     1680

atgatttcct agtagaactc acagaaataa agagctgtta tactgtgaa                 1729


<210>  72
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg 
            20                  


<210>  73
<211>  1107
<212>  DNA
<213>  Listeria monocytogenes

<400>  73
atggtgacag gctggcatcg tccaacatgg attgaaatag accgcgcagc aattcgcgaa       60

aatataaaaa atgaacaaaa taaactcccg gaaagtgtcg acttatgggc agtagtcaaa      120

gctaatgcat atggtcacgg aattatcgaa gttgctagga cggcgaaaga agctggagca      180

aaaggtttct gcgtagccat tttagatgag gcactggctc ttagagaagc tggatttcaa      240

gatgacttta ttcttgtgct tggtgcaacc agaaaagaag atgctaatct ggcagccaaa      300

aaccacattt cacttactgt ttttagagaa gattggctag agaatctaac gctagaagca      360

acacttcgaa ttcatttaaa agtagatagc ggtatggggc gtctcggtat tcgtacgact      420

gaagaagcac ggcgaattga agcaaccagt actaatgatc accaattaca actggaaggt      480

atttacacgc attttgcaac agccgaccag ctagaaacta gttattttga acaacaatta      540

gctaagttcc aaacgatttt aacgagttta aaaaaacgac caacttatgt tcatacagcc      600

aattcagctg cttcattgtt acagccacaa atcgggtttg atgcgattcg ctttggtatt      660

tcgatgtatg gattaactcc ctccacagaa atcaaaacta gcttgccgtt tgagcttaaa      720

cctgcacttg cactctatac cgagatggtt catgtgaaag aacttgcacc aggcgatagc      780

gttagctacg gagcaactta tacagcaaca gagcgagaat gggttgcgac attaccaatt      840

ggctatgcgg atggattgat tcgtcattac agtggtttcc atgttttagt agacggtgaa      900

ccagctccaa tcattggtcg agtttgtatg gatcaaacca tcataaaact accacgtgaa      960

tttcaaactg gttcaaaagt aacgataatt ggcaaagatc atggtaacac ggtaacagca     1020

gatgatgccg ctcaatattt agatacaatt aattatgagg taacttgttt gttaaatgag     1080

cgcataccta gaaaatacat ccattag                                         1107


<210>  74
<211>  368
<212>  PRT
<213>  Listeria monocytogenes

<400>  74

Met Val Thr Gly Trp His Arg Pro Thr Trp Ile Glu Ile Asp Arg Ala 
1               5                   10                  15      


Ala Ile Arg Glu Asn Ile Lys Asn Glu Gln Asn Lys Leu Pro Glu Ser 
            20                  25                  30          


Val Asp Leu Trp Ala Val Val Lys Ala Asn Ala Tyr Gly His Gly Ile 
        35                  40                  45              


Ile Glu Val Ala Arg Thr Ala Lys Glu Ala Gly Ala Lys Gly Phe Cys 
    50                  55                  60                  


Val Ala Ile Leu Asp Glu Ala Leu Ala Leu Arg Glu Ala Gly Phe Gln 
65                  70                  75                  80  


Asp Asp Phe Ile Leu Val Leu Gly Ala Thr Arg Lys Glu Asp Ala Asn 
                85                  90                  95      


Leu Ala Ala Lys Asn His Ile Ser Leu Thr Val Phe Arg Glu Asp Trp 
            100                 105                 110         


Leu Glu Asn Leu Thr Leu Glu Ala Thr Leu Arg Ile His Leu Lys Val 
        115                 120                 125             


Asp Ser Gly Met Gly Arg Leu Gly Ile Arg Thr Thr Glu Glu Ala Arg 
    130                 135                 140                 


Arg Ile Glu Ala Thr Ser Thr Asn Asp His Gln Leu Gln Leu Glu Gly 
145                 150                 155                 160 


Ile Tyr Thr His Phe Ala Thr Ala Asp Gln Leu Glu Thr Ser Tyr Phe 
                165                 170                 175     


Glu Gln Gln Leu Ala Lys Phe Gln Thr Ile Leu Thr Ser Leu Lys Lys 
            180                 185                 190         


Arg Pro Thr Tyr Val His Thr Ala Asn Ser Ala Ala Ser Leu Leu Gln 
        195                 200                 205             


Pro Gln Ile Gly Phe Asp Ala Ile Arg Phe Gly Ile Ser Met Tyr Gly 
    210                 215                 220                 


Leu Thr Pro Ser Thr Glu Ile Lys Thr Ser Leu Pro Phe Glu Leu Lys 
225                 230                 235                 240 


Pro Ala Leu Ala Leu Tyr Thr Glu Met Val His Val Lys Glu Leu Ala 
                245                 250                 255     


Pro Gly Asp Ser Val Ser Tyr Gly Ala Thr Tyr Thr Ala Thr Glu Arg 
            260                 265                 270         


Glu Trp Val Ala Thr Leu Pro Ile Gly Tyr Ala Asp Gly Leu Ile Arg 
        275                 280                 285             


His Tyr Ser Gly Phe His Val Leu Val Asp Gly Glu Pro Ala Pro Ile 
    290                 295                 300                 


Ile Gly Arg Val Cys Met Asp Gln Thr Ile Ile Lys Leu Pro Arg Glu 
305                 310                 315                 320 


Phe Gln Thr Gly Ser Lys Val Thr Ile Ile Gly Lys Asp His Gly Asn 
                325                 330                 335     


Thr Val Thr Ala Asp Asp Ala Ala Gln Tyr Leu Asp Thr Ile Asn Tyr 
            340                 345                 350         


Glu Val Thr Cys Leu Leu Asn Glu Arg Ile Pro Arg Lys Tyr Ile His 
        355                 360                 365             


<210>  75
<211>  870
<212>  DNA
<213>  Listeria monocytogenes

<400>  75
atgaaagtat tagtaaataa ccatttagtt gaaagagaag atgccacagt tgacattgaa       60

gaccgcggat atcagtttgg tgatggtgta tatgaagtag ttcgtctata taatggaaaa      120

ttctttactt ataatgaaca cattgatcgc ttatatgcta gtgcagcaaa aattgactta      180

gttattcctt attccaaaga agagctacgt gaattacttg aaaaattagt tgccgaaaat      240

aatatcaata cagggaatgt ctatttacaa gtgactcgtg gtgttcaaaa cccacgtaat      300

catgtaatcc ctgatgattt ccctctagaa ggcgttttaa cagcagcagc tcgtgaagta      360

cctagaaacg agcgtcaatt cgttgaaggt ggaacggcga ttacagaaga agatgtgcgc      420

tggttacgct gtgatattaa gagcttaaac cttttaggaa atattctagc aaaaaataaa      480

gcacatcaac aaaatgcttt ggaagctatt ttacatcgcg gggaacaagt aacagaatgt      540

tctgcttcaa acgtttctat tattaaagat ggtgtattat ggacgcatgc ggcagataac      600

ttaatcttaa atggtatcac tcgtcaagtt atcattgatg ttgcgaaaaa gaatggcatt      660

cctgttaaag aagcggattt cactttaaca gaccttcgtg aagcggatga agtgttcatt      720

tcaagtacaa ctattgaaat tacacctatt acgcatattg acggagttca agtagctgac      780

ggaaaacgtg gaccaattac agcgcaactt catcaatatt ttgtagaaga aatcactcgt      840

gcatgtggcg aattagagtt tgcaaaataa                                       870


<210>  76
<211>  289
<212>  PRT
<213>  Listeria monocytogenes

<400>  76

Met Lys Val Leu Val Asn Asn His Leu Val Glu Arg Glu Asp Ala Thr 
1               5                   10                  15      


Val Asp Ile Glu Asp Arg Gly Tyr Gln Phe Gly Asp Gly Val Tyr Glu 
            20                  25                  30          


Val Val Arg Leu Tyr Asn Gly Lys Phe Phe Thr Tyr Asn Glu His Ile 
        35                  40                  45              


Asp Arg Leu Tyr Ala Ser Ala Ala Lys Ile Asp Leu Val Ile Pro Tyr 
    50                  55                  60                  


Ser Lys Glu Glu Leu Arg Glu Leu Leu Glu Lys Leu Val Ala Glu Asn 
65                  70                  75                  80  


Asn Ile Asn Thr Gly Asn Val Tyr Leu Gln Val Thr Arg Gly Val Gln 
                85                  90                  95      


Asn Pro Arg Asn His Val Ile Pro Asp Asp Phe Pro Leu Glu Gly Val 
            100                 105                 110         


Leu Thr Ala Ala Ala Arg Glu Val Pro Arg Asn Glu Arg Gln Phe Val 
        115                 120                 125             


Glu Gly Gly Thr Ala Ile Thr Glu Glu Asp Val Arg Trp Leu Arg Cys 
    130                 135                 140                 


Asp Ile Lys Ser Leu Asn Leu Leu Gly Asn Ile Leu Ala Lys Asn Lys 
145                 150                 155                 160 


Ala His Gln Gln Asn Ala Leu Glu Ala Ile Leu His Arg Gly Glu Gln 
                165                 170                 175     


Val Thr Glu Cys Ser Ala Ser Asn Val Ser Ile Ile Lys Asp Gly Val 
            180                 185                 190         


Leu Trp Thr His Ala Ala Asp Asn Leu Ile Leu Asn Gly Ile Thr Arg 
        195                 200                 205             


Gln Val Ile Ile Asp Val Ala Lys Lys Asn Gly Ile Pro Val Lys Glu 
    210                 215                 220                 


Ala Asp Phe Thr Leu Thr Asp Leu Arg Glu Ala Asp Glu Val Phe Ile 
225                 230                 235                 240 


Ser Ser Thr Thr Ile Glu Ile Thr Pro Ile Thr His Ile Asp Gly Val 
                245                 250                 255     


Gln Val Ala Asp Gly Lys Arg Gly Pro Ile Thr Ala Gln Leu His Gln 
            260                 265                 270         


Tyr Phe Val Glu Glu Ile Thr Arg Ala Cys Gly Glu Leu Glu Phe Ala 
        275                 280                 285             


Lys 
    


<210>  77
<211>  6523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid pAdv142

<400>  77
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgagattgt gggaggctgg gagtgcgaga agcattccca accctggcag gtgcttgtgg     2460

cctctcgtgg cagggcagtc tgcggcggtg ttctggtgca cccccagtgg gtcctcacag     2520

ctgcccactg catcaggaac aaaagcgtga tcttgctggg tcggcacagc ctgtttcatc     2580

ctgaagacac aggccaggta tttcaggtca gccacagctt cccacacccg ctctacgata     2640

tgagcctcct gaagaatcga ttcctcaggc caggtgatga ctccagccac gacctcatgc     2700

tgctccgcct gtcagagcct gccgagctca cggatgctgt gaaggtcatg gacctgccca     2760

cccaggagcc agcactgggg accacctgct acgcctcagg ctggggcagc attgaaccag     2820

aggagttctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg     2880

tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga     2940

cagggggcaa aagcacctgc tcgggtgatt ctgggggccc acttgtctgt tatggtgtgc     3000

ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg ccttccctgt     3060

acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc aacccctaac     3120

ccgggccact aactcaacgc tagtagtgga tttaatccca aatgagccaa cagaaccaga     3180

accagaaaca gaacaagtaa cattggagtt agaaatggaa gaagaaaaaa gcaatgattt     3240

cgtgtgaata atgcacgaaa tcattgctta tttttttaaa aagcgatata ctagatataa     3300

cgaaacaacg aactgaataa agaatacaaa aaaagagcca cgaccagtta aagcctgaga     3360

aactttaact gcgagcctta attgattacc accaatcaat taaagaagtc gagacccaaa     3420

atttggtaaa gtatttaatt actttattaa tcagatactt aaatatctgt aaacccatta     3480

tatcgggttt ttgaggggat ttcaagtctt taagaagata ccaggcaatc aattaagaaa     3540

aacttagttg attgcctttt ttgttgtgat tcaactttga tcgtagcttc taactaatta     3600

attttcgtaa gaaaggagaa cagctgaatg aatatccctt ttgttgtaga aactgtgctt     3660

catgacggct tgttaaagta caaatttaaa aatagtaaaa ttcgctcaat cactaccaag     3720

ccaggtaaaa gtaaaggggc tatttttgcg tatcgctcaa aaaaaagcat gattggcgga     3780

cgtggcgttg ttctgacttc cgaagaagcg attcacgaaa atcaagatac atttacgcat     3840

tggacaccaa acgtttatcg ttatggtacg tatgcagacg aaaaccgttc atacactaaa     3900

ggacattctg aaaacaattt aagacaaatc aataccttct ttattgattt tgatattcac     3960

acggaaaaag aaactatttc agcaagcgat attttaacaa cagctattga tttaggtttt     4020

atgcctacgt taattatcaa atctgataaa ggttatcaag catattttgt tttagaaacg     4080

ccagtctatg tgacttcaaa atcagaattt aaatctgtca aagcagccaa aataatctcg     4140

caaaatatcc gagaatattt tggaaagtct ttgccagttg atctaacgtg caatcatttt     4200

gggattgctc gtataccaag aacggacaat gtagaatttt ttgatcccaa ttaccgttat     4260

tctttcaaag aatggcaaga ttggtctttc aaacaaacag ataataaggg ctttactcgt     4320

tcaagtctaa cggttttaag cggtacagaa ggcaaaaaac aagtagatga accctggttt     4380

aatctcttat tgcacgaaac gaaattttca ggagaaaagg gtttagtagg gcgcaatagc     4440

gttatgttta ccctctcttt agcctacttt agttcaggct attcaatcga aacgtgcgaa     4500

tataatatgt ttgagtttaa taatcgatta gatcaaccct tagaagaaaa agaagtaatc     4560

aaaattgtta gaagtgccta ttcagaaaac tatcaagggg ctaataggga atacattacc     4620

attctttgca aagcttgggt atcaagtgat ttaaccagta aagatttatt tgtccgtcaa     4680

gggtggttta aattcaagaa aaaaagaagc gaacgtcaac gtgttcattt gtcagaatgg     4740

aaagaagatt taatggctta tattagcgaa aaaagcgatg tatacaagcc ttatttagcg     4800

acgaccaaaa aagagattag agaagtgcta ggcattcctg aacggacatt agataaattg     4860

ctgaaggtac tgaaggcgaa tcaggaaatt ttctttaaga ttaaaccagg aagaaatggt     4920

ggcattcaac ttgctagtgt taaatcattg ttgctatcga tcattaaatt aaaaaaagaa     4980

gaacgagaaa gctatataaa ggcgctgaca gcttcgttta atttagaacg tacatttatt     5040

caagaaactc taaacaaatt ggcagaacgc cccaaaacgg acccacaact cgatttgttt     5100

agctacgata caggctgaaa ataaaacccg cactatgcca ttacatttat atctatgata     5160

cgtgtttgtt tttctttgct ggctagctta attgcttata tttacctgca ataaaggatt     5220

tcttacttcc attatactcc cattttccaa aaacatacgg ggaacacggg aacttattgt     5280

acaggccacc tcatagttaa tggtttcgag ccttcctgca atctcatcca tggaaatata     5340

ttcatccccc tgccggccta ttaatgtgac ttttgtgccc ggcggatatt cctgatccag     5400

ctccaccata aattggtcca tgcaaattcg gccggcaatt ttcaggcgtt ttcccttcac     5460

aaggatgtcg gtccctttca attttcggag ccagccgtcc gcatagccta caggcaccgt     5520

cccgatccat gtgtcttttt ccgctgtgta ctcggctccg tagctgacgc tctcgccttt     5580

tctgatcagt ttgacatgtg acagtgtcga atgcagggta aatgccggac gcagctgaaa     5640

cggtatctcg tccgacatgt cagcagacgg gcgaaggcca tacatgccga tgccgaatct     5700

gactgcatta aaaaagcctt ttttcagccg gagtccagcg gcgctgttcg cgcagtggac     5760

cattagattc tttaacggca gcggagcaat cagctcttta aagcgctcaa actgcattaa     5820

gaaatagcct ctttcttttt catccgctgt cgcaaaatgg gtaaataccc ctttgcactt     5880

taaacgaggg ttgcggtcaa gaattgccat cacgttctga acttcttcct ctgtttttac     5940

accaagtctg ttcatccccg tatcgacctt cagatgaaaa tgaagagaac cttttttcgt     6000

gtggcgggct gcctcctgaa gccattcaac agaataacct gttaaggtca cgtcatactc     6060

agcagcgatt gccacatact ccgggggaac cgcgccaagc accaatatag gcgccttcaa     6120

tccctttttg cgcagtgaaa tcgcttcatc caaaatggcc acggccaagc atgaagcacc     6180

tgcgtcaaga gcagcctttg ctgtttctgc atcaccatgc ccgtaggcgt ttgctttcac     6240

aactgccatc aagtggacat gttcaccgat atgttttttc atattgctga cattttcctt     6300

tatcgcggac aagtcaattt ccgcccacgt atctctgtaa aaaggttttg tgctcatgga     6360

aaactcctct cttttttcag aaaatcccag tacgtaatta agtatttgag aattaatttt     6420

atattgatta atactaagtt tacccagttt tcacctaaaa aacaaatgat gagataatag     6480

ctccaaaggc taaagaggac tataccaact atttgttaat taa                       6523


<210>  78
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adv271-actAF1 primer

<400>  78
cggaattcgg atccgcgcca aatcattggt tgattg                                 36


<210>  79
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adv272-actAR1 primer

<400>  79
gcgagtcgac gtcggggtta atcgtaatgc aattggc                                37


<210>  80
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adv273-actAF2 primer

<400>  80
gcgagtcgac ccatacgacg ttaattcttg caatg                                  35


<210>  81
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adv274-actAR2 primer

<400>  81
gatactgcag ggatccttcc cttctcggta atcagtcac                              39


<210>  82
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 3 which binds externally to actA region

<400>  82
tgggatggcc aagaaattc                                                    19


<210>  83
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 4 which binds externally to actA region

<400>  83
ctaccatgtc ttccgttgct tg                                                22


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FvB IC1 peptide epitope

<400>  84

Arg Leu Leu Gln Glu Thr Glu Leu Val 
1               5                   


