                               SEQUENCE LISTING

<110> MODERNA THERAPEUTICS, INC.
 
<120> CHIMERIC POLYNUCLEOTIDES

<130> 2030.1137PCT/M137.20

<140>
<141>

<150> 62/045,359
<151> 2014-09-03

<150> 62/025,399
<151> 2014-07-16

<160> 24    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 2
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210> 3
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
attgggcacc cgtaaggg                                                     18


<210> 4
<211> 920
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggtatc caagggggag gaggacaaca      120

tggcgatcat caaggagttc atgcgattca aggtgcacat ggaaggttcg gtcaacggac      180

acgaatttga aatcgaagga gagggtgaag gaaggcccta tgaagggaca cagaccgcga      240

aactcaaggt cacgaaaggg ggaccacttc ctttcgcctg ggacattctt tcgccccagt      300

ttatgtacgg gtccaaagca tatgtgaagc atcccgccga tattcctgac tatctgaaac      360

tcagctttcc cgagggattc aagtgggagc gggtcatgaa ctttgaggac gggggtgtag      420

tcaccgtaac ccaagactca agcctccaag acggcgagtt catctacaag gtcaaactgc      480

gggggactaa ctttccgtcg gatgggccgg tgatgcagaa gaaaacgatg ggatgggaag      540

cgtcatcgga gaggatgtac ccagaagatg gtgcattgaa gggggagatc aagcagagac      600

tgaagttgaa agatggggga cattatgatg ccgaggtgaa aacgacatac aaagcgaaaa      660

agccggtgca gcttcccgga gcgtataatg tgaatatcaa gttggatatt acttcacaca      720

atgaggacta cacaattgtc gaacagtacg aacgcgctga gggtagacac tcgacgggag      780

gcatggacga gttgtacaaa tgataatagg ctggagcctc ggtggccatg cttcttgccc      840

cttgggcctc cccccagccc ctcctcccct tcctgcaccc gtacccccgt ggtctttgaa      900

taaagtctga gtgggcggct                                                  920


<210> 5
<211> 725
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggtttt taccctcgaa gattttgtcg      120

gagattggag acagactgcc ggatacaacc ttgaccaagt cctcgagcaa ggcggtgtgt      180

cgtcactctt ccaaaacctg ggtgtgtccg tgactcccat ccagcgcatc gtcctgagcg      240

gcgaaaatgg gttgaagatc gacatccatg tgatcattcc atacgaggga ctgtccgggg      300

accagatggg tcagatcgaa aagattttca aagtggtgta cccggtcgac gatcatcact      360

tcaaggtgat cctgcactac ggaacgctgg tgatcgatgg ggtgaccccg aacatgattg      420

actatttcgg acggccttac gagggcatcg cagtgttcga cggaaagaag atcaccgtga      480

ccggcactct gtggaatgga aacaaaatca tcgacgaacg cctgatcaat ccggatggct      540

cgctgttgtt ccgggtgacc attaacggag tcactggatg gaggctctgc gagcgcatcc      600

ttgcgtgata ataggctgga gcctcggtgg ccatgcttct tgccccttgg gcctcccccc      660

agcccctcct ccccttcctg cacccgtacc cccgtggtct ttgaataaag tctgagtggg      720

cggct                                                                  725


<210> 6
<211> 824
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggccgg tcccgcgacc caaagcccca      120

tgaaacttat ggccctgcag ttgctgcttt ggcactcggc cctctggaca gtccaagaag      180

cgactcctct cggacctgcc tcatcgttgc cgcagtcatt ccttttgaag tgtctggagc      240

aggtgcgaaa gattcagggc gatggagccg cactccaaga gaagctctgc gcgacataca      300

aactttgcca tcccgaggag ctcgtactgc tcgggcacag cttggggatt ccctgggctc      360

ctctctcgtc ctgtccgtcg caggctttgc agttggcagg gtgcctttcc cagctccact      420

ccggtttgtt cttgtatcag ggactgctgc aagcccttga gggaatctcg ccagaattgg      480

gcccgacgct ggacacgttg cagctcgacg tggcggattt cgcaacaacc atctggcagc      540

agatggagga actggggatg gcacccgcgc tgcagcccac gcagggggca atgccggcct      600

ttgcgtccgc gtttcagcgc agggcgggtg gagtcctcgt agcgagccac cttcaatcat      660

ttttggaagt ctcgtaccgg gtgctgagac atcttgcgca gccgtgataa taggctggag      720

cctcggtggc catgcttctt gccccttggg cctcccccca gcccctcctc cccttcctgc      780

acccgtaccc ccgtggtctt tgaataaagt ctgagtgggc ggct                       824


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
taatacgact cactataggg                                                   20


<210> 8
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 8
gccgcccact cagactttat tcaaagacca c                                      31


<210> 9
<211> 111
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 9
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt gccgcccact cagactttat tcaaagacca c               111


<210> 10
<211> 171
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 10
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      120

tttttttttt tttttttttt gccgcccact cagactttat tcaaagacca c               171


<210> 11
<211> 874
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guauccaagg       60

gggaggagga caacauggcg aucaucaagg aguucaugcg auucaaggug cacauggaag      120

guucggucaa cggacacgaa uuugaaaucg aaggagaggg ugaaggaagg cccuaugaag      180

ggacacagac cgcgaaacuc aaggucacga aagggggacc acuuccuuuc gccugggaca      240

uucuuucgcc ccaguuuaug uacgggucca aagcauaugu gaagcauccc gccgauauuc      300

cugacuaucu gaaacucagc uuucccgagg gauucaagug ggagcggguc augaacuuug      360

aggacggggg uguagucacc guaacccaag acucaagccu ccaagacggc gaguucaucu      420

acaaggucaa acugcggggg acuaacuuuc cgucggaugg gccggugaug cagaagaaaa      480

cgaugggaug ggaagcguca ucggagagga uguacccaga agauggugca uugaaggggg      540

agaucaagca gagacugaag uugaaagaug ggggacauua ugaugccgag gugaaaacga      600

cauacaaagc gaaaaagccg gugcagcuuc ccggagcgua uaaugugaau aucaaguugg      660

auauuacuuc acacaaugag gacuacacaa uugucgaaca guacgaacgc gcugagggua      720

gacacucgac gggaggcaug gacgaguugu acaaaugaua auaggcugga gccucggugg      780

ccaugcuucu ugccccuugg gccucccccc agccccuccu ccccuuccug cacccguacc      840

cccguggucu uugaauaaag ucugaguggg cggc                                  874


<210> 12
<211> 679
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guuuuuaccc       60

ucgaagauuu ugucggagau uggagacaga cugccggaua caaccuugac caaguccucg      120

agcaaggcgg ugugucguca cucuuccaaa accugggugu guccgugacu cccauccagc      180

gcaucguccu gagcggcgaa aauggguuga agaucgacau ccaugugauc auuccauacg      240

agggacuguc cggggaccag augggucaga ucgaaaagau uuucaaagug guguacccgg      300

ucgacgauca ucacuucaag gugauccugc acuacggaac gcuggugauc gaugggguga      360

ccccgaacau gauugacuau uucggacggc cuuacgaggg caucgcagug uucgacggaa      420

agaagaucac cgugaccggc acucugugga auggaaacaa aaucaucgac gaacgccuga      480

ucaauccgga uggcucgcug uuguuccggg ugaccauuaa cggagucacu ggauggaggc      540

ucugcgagcg cauccuugcg ugauaauagg cuggagccuc gguggccaug cuucuugccc      600

cuugggccuc cccccagccc cuccuccccu uccugcaccc guacccccgu ggucuuugaa      660

uaaagucuga gugggcggc                                                   679


<210> 13
<211> 778
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccggucccg       60

cgacccaaag ccccaugaaa cuuauggccc ugcaguugcu gcuuuggcac ucggcccucu      120

ggacagucca agaagcgacu ccucucggac cugccucauc guugccgcag ucauuccuuu      180

ugaagugucu ggagcaggug cgaaagauuc agggcgaugg agccgcacuc caagagaagc      240

ucugcgcgac auacaaacuu ugccaucccg aggagcucgu acugcucggg cacagcuugg      300

ggauucccug ggcuccucuc ucguccuguc cgucgcaggc uuugcaguug gcagggugcc      360

uuucccagcu ccacuccggu uuguucuugu aucagggacu gcugcaagcc cuugagggaa      420

ucucgccaga auugggcccg acgcuggaca cguugcagcu cgacguggcg gauuucgcaa      480

caaccaucug gcagcagaug gaggaacugg ggauggcacc cgcgcugcag cccacgcagg      540

gggcaaugcc ggccuuugcg uccgcguuuc agcgcagggc ggguggaguc cucguagcga      600

gccaccuuca aucauuuuug gaagucucgu accgggugcu gagacaucuu gcgcagccgu      660

gauaauaggc uggagccucg guggccaugc uucuugcccc uugggccucc ccccagcccc      720

uccuccccuu ccugcacccg uacccccgug gucuuugaau aaagucugag ugggcggc        778


<210> 14
<211> 954
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guauccaagg       60

gggaggagga caacauggcg aucaucaagg aguucaugcg auucaaggug cacauggaag      120

guucggucaa cggacacgaa uuugaaaucg aaggagaggg ugaaggaagg cccuaugaag      180

ggacacagac cgcgaaacuc aaggucacga aagggggacc acuuccuuuc gccugggaca      240

uucuuucgcc ccaguuuaug uacgggucca aagcauaugu gaagcauccc gccgauauuc      300

cugacuaucu gaaacucagc uuucccgagg gauucaagug ggagcggguc augaacuuug      360

aggacggggg uguagucacc guaacccaag acucaagccu ccaagacggc gaguucaucu      420

acaaggucaa acugcggggg acuaacuuuc cgucggaugg gccggugaug cagaagaaaa      480

cgaugggaug ggaagcguca ucggagagga uguacccaga agauggugca uugaaggggg      540

agaucaagca gagacugaag uugaaagaug ggggacauua ugaugccgag gugaaaacga      600

cauacaaagc gaaaaagccg gugcagcuuc ccggagcgua uaaugugaau aucaaguugg      660

auauuacuuc acacaaugag gacuacacaa uugucgaaca guacgaacgc gcugagggua      720

gacacucgac gggaggcaug gacgaguugu acaaaugaua auaggcugga gccucggugg      780

ccaugcuucu ugccccuugg gccucccccc agccccuccu ccccuuccug cacccguacc      840

cccguggucu uugaauaaag ucugaguggg cggcaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa            954


<210> 15
<211> 1014
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guauccaagg       60

gggaggagga caacauggcg aucaucaagg aguucaugcg auucaaggug cacauggaag      120

guucggucaa cggacacgaa uuugaaaucg aaggagaggg ugaaggaagg cccuaugaag      180

ggacacagac cgcgaaacuc aaggucacga aagggggacc acuuccuuuc gccugggaca      240

uucuuucgcc ccaguuuaug uacgggucca aagcauaugu gaagcauccc gccgauauuc      300

cugacuaucu gaaacucagc uuucccgagg gauucaagug ggagcggguc augaacuuug      360

aggacggggg uguagucacc guaacccaag acucaagccu ccaagacggc gaguucaucu      420

acaaggucaa acugcggggg acuaacuuuc cgucggaugg gccggugaug cagaagaaaa      480

cgaugggaug ggaagcguca ucggagagga uguacccaga agauggugca uugaaggggg      540

agaucaagca gagacugaag uugaaagaug ggggacauua ugaugccgag gugaaaacga      600

cauacaaagc gaaaaagccg gugcagcuuc ccggagcgua uaaugugaau aucaaguugg      660

auauuacuuc acacaaugag gacuacacaa uugucgaaca guacgaacgc gcugagggua      720

gacacucgac gggaggcaug gacgaguugu acaaaugaua auaggcugga gccucggugg      780

ccaugcuucu ugccccuugg gccucccccc agccccuccu ccccuuccug cacccguacc      840

cccguggucu uugaauaaag ucugaguggg cggcaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           1014


<210> 16
<211> 819
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guuuuuaccc       60

ucgaagauuu ugucggagau uggagacaga cugccggaua caaccuugac caaguccucg      120

agcaaggcgg ugugucguca cucuuccaaa accugggugu guccgugacu cccauccagc      180

gcaucguccu gagcggcgaa aauggguuga agaucgacau ccaugugauc auuccauacg      240

agggacuguc cggggaccag augggucaga ucgaaaagau uuucaaagug guguacccgg      300

ucgacgauca ucacuucaag gugauccugc acuacggaac gcuggugauc gaugggguga      360

ccccgaacau gauugacuau uucggacggc cuuacgaggg caucgcagug uucgacggaa      420

agaagaucac cgugaccggc acucugugga auggaaacaa aaucaucgac gaacgccuga      480

ucaauccgga uggcucgcug uuguuccggg ugaccauuaa cggagucacu ggauggaggc      540

ucugcgagcg cauccuugcg ugauaauagg cuggagccuc gguggccaug cuucuugccc      600

cuugggccuc cccccagccc cuccuccccu uccugcaccc guacccccgu ggucuuugaa      660

uaaagucuga gugggcggca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                             819


<210> 17
<211> 918
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccggucccg       60

cgacccaaag ccccaugaaa cuuauggccc ugcaguugcu gcuuuggcac ucggcccucu      120

ggacagucca agaagcgacu ccucucggac cugccucauc guugccgcag ucauuccuuu      180

ugaagugucu ggagcaggug cgaaagauuc agggcgaugg agccgcacuc caagagaagc      240

ucugcgcgac auacaaacuu ugccaucccg aggagcucgu acugcucggg cacagcuugg      300

ggauucccug ggcuccucuc ucguccuguc cgucgcaggc uuugcaguug gcagggugcc      360

uuucccagcu ccacuccggu uuguucuugu aucagggacu gcugcaagcc cuugagggaa      420

ucucgccaga auugggcccg acgcuggaca cguugcagcu cgacguggcg gauuucgcaa      480

caaccaucug gcagcagaug gaggaacugg ggauggcacc cgcgcugcag cccacgcagg      540

gggcaaugcc ggccuuugcg uccgcguuuc agcgcagggc ggguggaguc cucguagcga      600

gccaccuuca aucauuuuug gaagucucgu accgggugcu gagacaucuu gcgcagccgu      660

gauaauaggc uggagccucg guggccaugc uucuugcccc uugggccucc ccccagcccc      720

uccuccccuu ccugcacccg uacccccgug gucuuugaau aaagucugag ugggcggcaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaa                                                    918


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ggacaacaac aacaacaaca a                                                 21


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ggacaacaac aacaacaaca a                                                 21


<210> 20
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
tttttttttt tttttttttt tttttttttt tttttgccgc ccactcagac tttat            55


<210> 21
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120


<210> 22
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
actcttcttt tctctcttat ttcccttgtt gttgttgttg ttgtcc                      46


<210> 23
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (41)..(80)
<223> May or may not be present

<400> 23
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa                                                   80


<210> 24
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt      120

