                         SEQUENCE LISTING

<110>  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
       Hinck, Andrew
       Sun, LuZhe
       Zwieb, Christian
 
<120>  TGFB TYPE II-TYPE III RECEPTOR FUSIONS

<130>  UTFK.P0468WO

<140>  UNKNOWN
<141>  2015-07-14

<150>  62/024,253
<151>  2014-07-14

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg 
1               5                   10                  15      


Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile 
            20                  25                  30          


Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg 
        35                  40                  45              


Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys 
    50                  55                  60                  


Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys 
65                  70                  75                  80  


Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser 
                85                  90                  95      


Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr 
            100                 105                 110         


Asn Thr Ser Asn Pro Asp 
        115             


<210>  2
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Cys Glu Leu Ser Pro Ile Asn Ala Ser His Pro Val Gln Ala Leu Met 
1               5                   10                  15      


Glu Ser Phe Thr Val Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly 
            20                  25                  30          


Leu Pro Arg Glu Val His Val Leu Asn Leu Arg Ser Thr Asp Gln Gly 
        35                  40                  45              


Pro Gly Gln Arg Gln Arg Glu Val Thr Leu His Leu Asn Pro Ile Ala 
    50                  55                  60                  


Ser Val His Thr His His Lys Pro Ile Val Phe Leu Leu Asn Ser Pro 
65                  70                  75                  80  


Gln Pro Leu Val Trp His Leu Lys Thr Glu Arg Leu Ala Ala Gly Val 
                85                  90                  95      


Pro Arg Leu Phe Leu Val Ser Glu Gly Ser Val Val Gln Phe Pro Ser 
            100                 105                 110         


Gly Asn Phe Ser Leu Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro Gln 
        115                 120                 125             


Glu Asn Glu His Leu Leu Arg Trp Ala Gln Lys Glu Tyr Gly Ala Val 
    130                 135                 140                 


Thr Ser Phe Thr Glu Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val 
145                 150                 155                 160 


Gly Glu Asp Gln Val Phe Pro Pro Thr Cys Asn Ile Gly Lys Asn Phe 
                165                 170                 175     


Leu Ser Leu Asn Tyr Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu 
            180                 185                 190         


Gly Cys Val Leu Pro Ser Gln Pro His Glu Lys Glu Val His Ile Ile 
        195                 200                 205             


Glu Leu Ile Thr Pro Ser Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp 
    210                 215                 220                 


Ile Ile Val Asp Ile Arg Pro Ala Gln Glu Asp Pro Glu Val Val Lys 
225                 230                 235                 240 


Asn Leu Val Leu Ile Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile 
                245                 250                 255     


Lys Ser Phe Asp Val Lys Gly Asn Leu Lys Val Ile Ala Pro Asn Ser 
            260                 265                 270         


Ile Gly Phe Gly Lys Glu Ser Glu Arg Ser Met Thr Met Thr Lys Leu 
        275                 280                 285             


Val Arg Asp Asp Ile Pro Ser Thr Gln Glu Asn Leu Met Lys Trp Ala 
    290                 295                 300                 


Leu Asp Asn Gly Tyr Arg Pro Val Thr Ser Tyr Thr Met Ala Pro Val 
305                 310                 315                 320 


Ala Asn Arg Phe His Leu Arg Leu Glu Asn Asn Glu Glu Met Arg Asp 
                325                 330                 335     


Glu Glu Val His Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro 
            340                 345                 350         


Asp His Pro Pro Ala Leu Asp Asn Pro Leu Phe Pro Gly Glu Gly Ser 
        355                 360                 365             


Pro Asn Gly Gly Leu Pro Phe Pro Phe Pro Asp Ile Pro Arg Arg Gly 
    370                 375                 380                 


Trp Lys Glu Gly Glu Asp Arg Ile Pro Arg Pro Lys Gln Pro Ile Val 
385                 390                 395                 400 


Pro Ser Val Gln Leu Leu Pro Asp His Arg Glu Pro Glu Glu Val Gln 
                405                 410                 415     


Gly Gly Val Asp Ile Ala Leu Ser Val Lys Cys Asp His Glu Lys Met 
            420                 425                 430         


Val Val Ala Val Asp Lys Asp Ser Phe Gln Thr Asn Gly Tyr Ser Gly 
        435                 440                 445             


Met Glu Leu Thr Leu Leu Asp Pro Ser Cys Lys Ala Lys Met Asn Gly 
    450                 455                 460                 


Thr His Phe Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg His 
465                 470                 475                 480 


Arg Arg Ser Thr Pro Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Val 
                485                 490                 495     


Gln Ala Pro Ser Pro Gly Asp Ser Ala Gly Trp Pro Asp Gly Tyr Glu 
            500                 505                 510         


Asp Leu Glu Ala Gly Asp Asn Gly Phe Pro Gly Asp Gly Asp Glu Gly 
        515                 520                 525             


Glu Thr Ala Pro Leu Ser Arg Ala Gly Val Val Val Phe Asn Cys Ser 
    530                 535                 540                 


Leu Arg Gln Leu Arg Asn Pro Ser Gly Phe Gln Gly Gln Leu Asp Gly 
545                 550                 555                 560 


Asn Ala Thr Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val 
                565                 570                 575     


Pro Ser Pro Gly Val Phe Ser Val Ala Glu Asn Glu His Val Tyr Val 
            580                 585                 590         


Glu Val Ser Val Thr Lys Ala Asp Gln Asp Leu Gly Phe Ala Ile Gln 
        595                 600                 605             


Thr Cys Phe Leu Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser Asp Tyr 
    610                 615                 620                 


Thr Ile Ile Glu Asn Ile Cys Pro Lys Asp Asp Ser Val Lys Phe Tyr 
625                 630                 635                 640 


Ser Ser Lys Arg Val His Phe Pro Ile Pro His Ala Glu Val Asp Lys 
                645                 650                 655     


Lys Arg Phe Ser Phe Leu Phe Lys Ser Val Phe Asn Thr Ser Leu Leu 
            660                 665                 670         


Phe Leu His Cys Glu Leu Thr Leu Cys Ser Arg Lys Lys Gly Ser Leu 
        675                 680                 685             


Lys Leu Pro Arg Cys Val Thr Pro Asp Asp Ala Cys Thr Ser Leu Asp 
    690                 695                 700                 


Ala Thr Met Ile Trp Thr Met Met Gln Asn Lys Lys Thr Phe Thr Lys 
705                 710                 715                 720 


Pro Leu Ala Val Val Leu Gln Val Asp 
                725                 


<210>  3
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Cys Glu Leu Ser Pro Ile Asn Ala Ser His Pro Val Gln Ala Leu Met 
1               5                   10                  15      


Glu Ser Phe Thr Val Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly 
            20                  25                  30          


Leu Pro Arg Glu Val His Val Leu Asn Leu Arg Ser Thr Asp Gln Gly 
        35                  40                  45              


Pro Gly Gln Arg Gln Arg Glu Val Thr Leu His Leu Asn Pro Ile Ala 
    50                  55                  60                  


Ser Val His Thr His His Lys Pro Ile Val Phe Leu Leu Asn Ser Pro 
65                  70                  75                  80  


Gln Pro Leu Val Trp His Leu Lys Thr Glu Arg Leu Ala Ala Gly Val 
                85                  90                  95      


Pro Arg Leu Phe Leu Val Ser Glu Gly Ser Val Val Gln Phe Pro Ser 
            100                 105                 110         


Gly Asn Phe Ser Leu Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro Gln 
        115                 120                 125             


Glu Asn Glu His Leu Leu Arg Trp Ala Gln Lys Glu Tyr Gly Ala Val 
    130                 135                 140                 


Thr Ser Phe Thr Glu Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val 
145                 150                 155                 160 


Gly Glu Asp Gln Val Phe Pro Pro Thr Cys Asn Ile Gly Lys Asn Phe 
                165                 170                 175     


Leu Ser Leu Asn Tyr Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu 
            180                 185                 190         


Gly Cys Val Leu Pro Ser Gln Pro His Glu Lys Glu Val His Ile Ile 
        195                 200                 205             


Glu Leu Ile Thr Pro Ser Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp 
    210                 215                 220                 


Ile Ile Val Asp Ile Arg Pro Ala Gln Glu Asp Pro Glu Val Val Lys 
225                 230                 235                 240 


Asn Leu Val Leu Ile Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile 
                245                 250                 255     


Lys Ser Phe Asp Val Lys Gly Asn Leu Lys Val Ile Ala Pro Asn Ser 
            260                 265                 270         


Ile Gly Phe Gly Lys Glu Ser Glu Arg Ser Met Thr Met Thr Lys Leu 
        275                 280                 285             


Val Arg Asp Asp Ile Pro Ser Thr Gln Glu Asn Leu Met Lys Trp Ala 
    290                 295                 300                 


Leu Asp Asn Gly Tyr Arg Pro Val Thr Ser Tyr Thr Met Ala Pro Val 
305                 310                 315                 320 


Ala Asn Arg Phe His Leu Arg Leu Glu Asn Asn Glu Glu Met Arg Asp 
                325                 330                 335     


Glu Glu Val His Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro 
            340                 345                 350         


Asp 
    


<210>  4
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Asp His Pro Pro Ala Leu Asp Asn Pro Leu Phe Pro Gly Glu Gly Ser 
1               5                   10                  15      


Pro Asn Gly Gly Leu Pro Phe Pro Phe Pro Asp Ile Pro Arg Arg Gly 
            20                  25                  30          


Trp Lys Glu Gly Glu Asp Arg Ile Pro Arg Pro Lys Gln Pro Ile Val 
        35                  40                  45              


Pro Ser Val Gln Leu Leu Pro Asp His Arg Glu Pro Glu Glu Val Gln 
    50                  55                  60                  


Gly Gly Val Asp Ile Ala Leu Ser Val Lys Cys Asp His Glu Lys Met 
65                  70                  75                  80  


Val Val Ala Val Asp Lys Asp Ser Phe Gln Thr Asn Gly Tyr Ser Gly 
                85                  90                  95      


Met Glu Leu Thr Leu Leu Asp Pro Ser Cys Lys Ala Lys Met Asn Gly 
            100                 105                 110         


Thr His Phe Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg His 
        115                 120                 125             


Arg Arg Ser Thr Pro Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Val 
    130                 135                 140                 


Gln Ala Pro Ser Pro Gly Asp Ser Ala Gly Trp Pro Asp Gly Tyr Glu 
145                 150                 155                 160 


Asp Leu Glu Ala Gly Asp Asn Gly Phe Pro Gly Asp Gly Asp Glu Gly 
                165                 170                 175     


Glu Thr Ala Pro Leu Ser Arg Ala Gly Val Val Val Phe Asn Cys Ser 
            180                 185                 190         


Leu Arg Gln Leu Arg Asn Pro Ser Gly Phe Gln Gly Gln Leu Asp Gly 
        195                 200                 205             


Asn Ala Thr Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val 
    210                 215                 220                 


Pro Ser Pro Gly Val Phe Ser Val Ala Glu Asn Glu His Val Tyr Val 
225                 230                 235                 240 


Glu Val Ser Val Thr Lys Ala Asp Gln Asp Leu Gly Phe Ala Ile Gln 
                245                 250                 255     


Thr Cys Phe Leu Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser Asp Tyr 
            260                 265                 270         


Thr Ile Ile Glu Asn Ile Cys Pro Lys Asp Asp Ser Val Lys Phe Tyr 
        275                 280                 285             


Ser Ser Lys Arg Val His Phe Pro Ile Pro His Ala Glu Val Asp Lys 
    290                 295                 300                 


Lys Arg Phe Ser Phe Leu Phe Lys Ser Val Phe Asn Thr Ser Leu Leu 
305                 310                 315                 320 


Phe Leu His Cys Glu Leu Thr Leu Cys Ser Arg Lys Lys Gly Ser Leu 
                325                 330                 335     


Lys Leu Pro Arg Cys Val Thr Pro Asp Asp Ala Cys Thr Ser Leu Asp 
            340                 345                 350         


Ala Thr Met Ile Trp Thr Met Met Gln Asn Lys Lys Thr Phe Thr Lys 
        355                 360                 365             


Pro Leu Ala Val Val Leu Gln Val Asp 
    370                 375         


<210>  5
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Asp His Pro Pro Ala Leu Asp Asn Pro Leu Phe Pro Gly Glu Gly Ser 
1               5                   10                  15      


Pro Asn Gly Gly Leu Pro Phe Pro Phe Pro Asp Ile Pro Arg Arg Gly 
            20                  25                  30          


Trp Lys Glu Gly Glu Asp Arg Ile Pro Arg Pro Lys Gln Pro Ile Val 
        35                  40                  45              


Pro Ser Val Gln Leu Leu Pro Asp His Arg Glu Pro Glu Glu Val Gln 
    50                  55                  60                  


Gly Gly Val Asp Ile Ala Leu Ser Val Lys Cys Asp His Glu Lys Met 
65                  70                  75                  80  


Val Val Ala Val Asp Lys Asp Ser Phe Gln Thr Asn Gly Tyr Ser Gly 
                85                  90                  95      


Met Glu Leu Thr Leu Leu Asp Pro Ser Cys Lys Ala Lys Met Asn Gly 
            100                 105                 110         


Thr His Phe Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg His 
        115                 120                 125             


Arg Arg Ser Thr Pro Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Val 
    130                 135                 140                 


Gln Ala Pro Ser Pro Gly Asp Ser Ala Gly Trp Pro Asp Gly Tyr Glu 
145                 150                 155                 160 


Asp Leu Glu Ala Gly Asp Asn Gly Phe Pro Gly Asp Gly Asp Glu Gly 
                165                 170                 175     


Glu Thr Ala Pro Leu Ser Arg Ala Gly Val Val Val Phe Asn Cys Ser 
            180                 185                 190         


Leu Arg Gln Leu Arg Asn Pro Ser Gly Phe Gln Gly Gln Leu 
        195                 200                 205     


<210>  6
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Asp Gly Asn Ala Thr Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe 
1               5                   10                  15      


Leu Val Pro Ser Pro Gly Val Phe Ser Val Ala Glu Asn Glu His Val 
            20                  25                  30          


Tyr Val Glu Val Ser Val Thr Lys Ala Asp Gln Asp Leu Gly Phe Ala 
        35                  40                  45              


Ile Gln Thr Cys Phe Leu Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser 
    50                  55                  60                  


Asp Tyr Thr Ile Ile Glu Asn Ile Cys Pro Lys Asp Asp Ser Val Lys 
65                  70                  75                  80  


Phe Tyr Ser Ser Lys Arg Val His Phe Pro Ile Pro His Ala Glu Val 
                85                  90                  95      


Asp Lys Lys Arg Phe Ser Phe Leu Phe Lys Ser Val Phe Asn Thr Ser 
            100                 105                 110         


Leu Leu Phe Leu His Cys Glu Leu Thr Leu Cys Ser Arg Lys Lys Gly 
        115                 120                 125             


Ser Leu Lys Leu Pro Arg Cys Val Thr Pro Asp Asp Ala Cys Thr Ser 
    130                 135                 140                 


Leu Asp Ala Thr Met Ile Trp Thr Met Met Gln Asn Lys Lys Thr Phe 
145                 150                 155                 160 


Thr Lys Pro Leu Ala Val Val Leu Gln Val Asp 
                165                 170     


<210>  7
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Ile Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser Ala Ala Ala Cys Glu Leu Ser Pro Ile Asn Ala Ser His Pro 
            20                  25                  30          


Val Gln Ala Leu Met Glu Ser Phe Thr Val Leu Ser Gly Cys Ala Ser 
        35                  40                  45              


Arg Gly Thr Thr Gly Leu Pro Arg Glu Val His Val Leu Asn Leu Arg 
    50                  55                  60                  


Ser Thr Asp Gln Gly Pro Gly Gln Arg Gln Arg Glu Val Thr Leu His 
65                  70                  75                  80  


Leu Asn Pro Ile Ala Ser Val His Thr His His Lys Pro Ile Val Phe 
                85                  90                  95      


Leu Leu Asn Ser Pro Gln Pro Leu Val Trp His Leu Lys Thr Glu Arg 
            100                 105                 110         


Leu Ala Ala Gly Val Pro Arg Leu Phe Leu Val Ser Glu Gly Ser Val 
        115                 120                 125             


Val Gln Phe Pro Ser Gly Asn Phe Ser Leu Thr Ala Glu Thr Glu Glu 
    130                 135                 140                 


Arg Asn Phe Pro Gln Glu Asn Glu His Leu Leu Arg Trp Ala Gln Lys 
145                 150                 155                 160 


Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu Leu Lys Ile Ala Arg Asn 
                165                 170                 175     


Ile Tyr Ile Lys Val Gly Glu Asp Gln Val Phe Pro Pro Thr Cys Asn 
            180                 185                 190         


Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr Leu Ala Glu Tyr Leu Gln 
        195                 200                 205             


Pro Lys Ala Ala Glu Gly Cys Val Leu Pro Ser Gln Pro His Glu Lys 
    210                 215                 220                 


Glu Val His Ile Ile Glu Leu Ile Thr Pro Ser Ser Asn Pro Tyr Ser 
225                 230                 235                 240 


Ala Phe Gln Val Asp Ile Ile Val Asp Ile Arg Pro Ala Gln Glu Asp 
                245                 250                 255     


Pro Glu Val Val Lys Asn Leu Val Leu Ile Leu Lys Cys Lys Lys Ser 
            260                 265                 270         


Val Asn Trp Val Ile Lys Ser Phe Asp Val Lys Gly Asn Leu Lys Val 
        275                 280                 285             


Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys Glu Ser Glu Arg Ser Met 
    290                 295                 300                 


Thr Met Thr Lys Leu Val Arg Asp Asp Ile Pro Ser Thr Gln Glu Asn 
305                 310                 315                 320 


Leu Met Lys Trp Ala Leu Asp Asn Gly Tyr Arg Pro Val Thr Ser Tyr 
                325                 330                 335     


Thr Met Ala Pro Val Ala Asn Arg Phe His Leu Arg Leu Glu Asn Asn 
            340                 345                 350         


Glu Glu Met Arg Asp Glu Glu Val His Thr Ile Pro Pro Glu Leu Arg 
        355                 360                 365             


Ile Leu Leu Asp Pro Asp Asp Gly Asn Ala Thr Phe Asn Met Glu Leu 
    370                 375                 380                 


Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Pro Gly Val Phe Ser Val 
385                 390                 395                 400 


Ala Glu Asn Glu His Val Tyr Val Glu Val Ser Val Thr Lys Ala Asp 
                405                 410                 415     


Gln Asp Leu Gly Phe Ala Ile Gln Thr Cys Phe Leu Ser Pro Tyr Ser 
            420                 425                 430         


Asn Pro Asp Arg Met Ser Asp Tyr Thr Ile Ile Glu Asn Ile Cys Pro 
        435                 440                 445             


Lys Asp Asp Ser Val Lys Phe Tyr Ser Ser Lys Arg Val His Phe Pro 
    450                 455                 460                 


Ile Pro His Ala Glu Val Asp Lys Lys Arg Phe Ser Phe Leu Phe Lys 
465                 470                 475                 480 


Ser Val Phe Asn Thr Ser Leu Leu Phe Leu His Cys Glu Leu Thr Leu 
                485                 490                 495     


Cys Ser Arg Lys Lys Gly Ser Leu Lys Leu Pro Arg Cys Val Thr Pro 
            500                 505                 510         


Asp Asp Ala Cys Thr Ser Leu Asp Ala Thr Met Ile Trp Thr Met Met 
        515                 520                 525             


Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala Val Val Leu Gln Val 
    530                 535                 540                 


Asp 
545 


<210>  8
<211>  886
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Ile Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser Ala Ala Ala Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
            20                  25                  30          


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
        35                  40                  45              


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
    50                  55                  60                  


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
65                  70                  75                  80  


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
                85                  90                  95      


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
            100                 105                 110         


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
        115                 120                 125             


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Leu Gly Pro Val 
    130                 135                 140                 


Glu Ser Ser Pro Gly His Gly Leu Asp Thr Ala Ala Ala Cys Glu Leu 
145                 150                 155                 160 


Ser Pro Ile Asn Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe 
                165                 170                 175     


Thr Val Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Arg 
            180                 185                 190         


Glu Val His Val Leu Asn Leu Arg Ser Thr Asp Gln Gly Pro Gly Gln 
        195                 200                 205             


Arg Gln Arg Glu Val Thr Leu His Leu Asn Pro Ile Ala Ser Val His 
    210                 215                 220                 


Thr His His Lys Pro Ile Val Phe Leu Leu Asn Ser Pro Gln Pro Leu 
225                 230                 235                 240 


Val Trp His Leu Lys Thr Glu Arg Leu Ala Ala Gly Val Pro Arg Leu 
                245                 250                 255     


Phe Leu Val Ser Glu Gly Ser Val Val Gln Phe Pro Ser Gly Asn Phe 
            260                 265                 270         


Ser Leu Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro Gln Glu Asn Glu 
        275                 280                 285             


His Leu Leu Arg Trp Ala Gln Lys Glu Tyr Gly Ala Val Thr Ser Phe 
    290                 295                 300                 


Thr Glu Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp 
305                 310                 315                 320 


Gln Val Phe Pro Pro Thr Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu 
                325                 330                 335     


Asn Tyr Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val 
            340                 345                 350         


Leu Pro Ser Gln Pro His Glu Lys Glu Val His Ile Ile Glu Leu Ile 
        355                 360                 365             


Thr Pro Ser Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Ile Val 
    370                 375                 380                 


Asp Ile Arg Pro Ala Gln Glu Asp Pro Glu Val Val Lys Asn Leu Val 
385                 390                 395                 400 


Leu Ile Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe 
                405                 410                 415     


Asp Val Lys Gly Asn Leu Lys Val Ile Ala Pro Asn Ser Ile Gly Phe 
            420                 425                 430         


Gly Lys Glu Ser Glu Arg Ser Met Thr Met Thr Lys Leu Val Arg Asp 
        435                 440                 445             


Asp Ile Pro Ser Thr Gln Glu Asn Leu Met Lys Trp Ala Leu Asp Asn 
    450                 455                 460                 


Gly Tyr Arg Pro Val Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg 
465                 470                 475                 480 


Phe His Leu Arg Leu Glu Asn Asn Glu Glu Met Arg Asp Glu Glu Val 
                485                 490                 495     


His Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Asp His Pro 
            500                 505                 510         


Pro Ala Leu Asp Asn Pro Leu Phe Pro Gly Glu Gly Ser Pro Asn Gly 
        515                 520                 525             


Gly Leu Pro Phe Pro Phe Pro Asp Ile Pro Arg Arg Gly Trp Lys Glu 
    530                 535                 540                 


Gly Glu Asp Arg Ile Pro Arg Pro Lys Gln Pro Ile Val Pro Ser Val 
545                 550                 555                 560 


Gln Leu Leu Pro Asp His Arg Glu Pro Glu Glu Val Gln Gly Gly Val 
                565                 570                 575     


Asp Ile Ala Leu Ser Val Lys Cys Asp His Glu Lys Met Val Val Ala 
            580                 585                 590         


Val Asp Lys Asp Ser Phe Gln Thr Asn Gly Tyr Ser Gly Met Glu Leu 
        595                 600                 605             


Thr Leu Leu Asp Pro Ser Cys Lys Ala Lys Met Asn Gly Thr His Phe 
    610                 615                 620                 


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg His Arg Arg Ser 
625                 630                 635                 640 


Thr Pro Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Val Gln Ala Pro 
                645                 650                 655     


Ser Pro Gly Asp Ser Ala Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
            660                 665                 670         


Ala Gly Asp Asn Gly Phe Pro Gly Asp Gly Asp Glu Gly Glu Thr Ala 
        675                 680                 685             


Pro Leu Ser Arg Ala Gly Val Val Val Phe Asn Cys Ser Leu Arg Gln 
    690                 695                 700                 


Leu Arg Asn Pro Ser Gly Phe Gln Gly Gln Leu Asp Gly Asn Ala Thr 
705                 710                 715                 720 


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Pro 
                725                 730                 735     


Gly Val Phe Ser Val Ala Glu Asn Glu His Val Tyr Val Glu Val Ser 
            740                 745                 750         


Val Thr Lys Ala Asp Gln Asp Leu Gly Phe Ala Ile Gln Thr Cys Phe 
        755                 760                 765             


Leu Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser Asp Tyr Thr Ile Ile 
    770                 775                 780                 


Glu Asn Ile Cys Pro Lys Asp Asp Ser Val Lys Phe Tyr Ser Ser Lys 
785                 790                 795                 800 


Arg Val His Phe Pro Ile Pro His Ala Glu Val Asp Lys Lys Arg Phe 
                805                 810                 815     


Ser Phe Leu Phe Lys Ser Val Phe Asn Thr Ser Leu Leu Phe Leu His 
            820                 825                 830         


Cys Glu Leu Thr Leu Cys Ser Arg Lys Lys Gly Ser Leu Lys Leu Pro 
        835                 840                 845             


Arg Cys Val Thr Pro Asp Asp Ala Cys Thr Ser Leu Asp Ala Thr Met 
    850                 855                 860                 


Ile Trp Thr Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala 
865                 870                 875                 880 


Val Val Leu Gln Val Asp 
                885     


<210>  9
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Ile Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser Ala Ala Ala Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
            20                  25                  30          


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
        35                  40                  45              


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
    50                  55                  60                  


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
65                  70                  75                  80  


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
                85                  90                  95      


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
            100                 105                 110         


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
        115                 120                 125             


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Leu Gly Pro Val 
    130                 135                 140                 


Glu Ser Ser Pro Gly His Gly Leu Asp Thr Ala Ala Ala Cys Glu Leu 
145                 150                 155                 160 


Ser Pro Ile Asn Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe 
                165                 170                 175     


Thr Val Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Arg 
            180                 185                 190         


Glu Val His Val Leu Asn Leu Arg Ser Thr Asp Gln Gly Pro Gly Gln 
        195                 200                 205             


Arg Gln Arg Glu Val Thr Leu His Leu Asn Pro Ile Ala Ser Val His 
    210                 215                 220                 


Thr His His Lys Pro Ile Val Phe Leu Leu Asn Ser Pro Gln Pro Leu 
225                 230                 235                 240 


Val Trp His Leu Lys Thr Glu Arg Leu Ala Ala Gly Val Pro Arg Leu 
                245                 250                 255     


Phe Leu Val Ser Glu Gly Ser Val Val Gln Phe Pro Ser Gly Asn Phe 
            260                 265                 270         


Ser Leu Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro Gln Glu Asn Glu 
        275                 280                 285             


His Leu Leu Arg Trp Ala Gln Lys Glu Tyr Gly Ala Val Thr Ser Phe 
    290                 295                 300                 


Thr Glu Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp 
305                 310                 315                 320 


Gln Val Phe Pro Pro Thr Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu 
                325                 330                 335     


Asn Tyr Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val 
            340                 345                 350         


Leu Pro Ser Gln Pro His Glu Lys Glu Val His Ile Ile Glu Leu Ile 
        355                 360                 365             


Thr Pro Ser Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Ile Val 
    370                 375                 380                 


Asp Ile Arg Pro Ala Gln Glu Asp Pro Glu Val Val Lys Asn Leu Val 
385                 390                 395                 400 


Leu Ile Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe 
                405                 410                 415     


Asp Val Lys Gly Asn Leu Lys Val Ile Ala Pro Asn Ser Ile Gly Phe 
            420                 425                 430         


Gly Lys Glu Ser Glu Arg Ser Met Thr Met Thr Lys Leu Val Arg Asp 
        435                 440                 445             


Asp Ile Pro Ser Thr Gln Glu Asn Leu Met Lys Trp Ala Leu Asp Asn 
    450                 455                 460                 


Gly Tyr Arg Pro Val Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg 
465                 470                 475                 480 


Phe His Leu Arg Leu Glu Asn Asn Glu Glu Met Arg Asp Glu Glu Val 
                485                 490                 495     


His Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Asp Asp Gly 
            500                 505                 510         


Asn Ala Thr Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val 
        515                 520                 525             


Pro Ser Pro Gly Val Phe Ser Val Ala Glu Asn Glu His Val Tyr Val 
    530                 535                 540                 


Glu Val Ser Val Thr Lys Ala Asp Gln Asp Leu Gly Phe Ala Ile Gln 
545                 550                 555                 560 


Thr Cys Phe Leu Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser Asp Tyr 
                565                 570                 575     


Thr Ile Ile Glu Asn Ile Cys Pro Lys Asp Asp Ser Val Lys Phe Tyr 
            580                 585                 590         


Ser Ser Lys Arg Val His Phe Pro Ile Pro His Ala Glu Val Asp Lys 
        595                 600                 605             


Lys Arg Phe Ser Phe Leu Phe Lys Ser Val Phe Asn Thr Ser Leu Leu 
    610                 615                 620                 


Phe Leu His Cys Glu Leu Thr Leu Cys Ser Arg Lys Lys Gly Ser Leu 
625                 630                 635                 640 


Lys Leu Pro Arg Cys Val Thr Pro Asp Asp Ala Cys Thr Ser Leu Asp 
                645                 650                 655     


Ala Thr Met Ile Trp Thr Met Met Gln Asn Lys Lys Thr Phe Thr Lys 
            660                 665                 670         


Pro Leu Ala Val Val Leu Gln Val Asp 
        675                 680     


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Ile Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser Ala Ala Ala 
            20      


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Gly Leu Gly Pro Val Glu Ser Ser Pro Gly His Gly Leu Asp Thr Ala 
1               5                   10                  15      


Ala Ala 
        


