                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       NAOR, David
       ESHKAR-SEBBAN, Lora
       AMAR, Keren-Or
       COHEN, Shmuel
 
<120>  ISOLATED POLYPEPTIDES OF CD44 AND USES THEREOF

<130>  62563

<150>  US 62/024,719
<151>  2014-07-15

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

Met Thr Ala Asp Val 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  2

Met Thr Ala Asp Val Asp Arg 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  3

Thr Arg Met Thr Ala Asp Val Asp Arg 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acylated-N terminus

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  C-Terminal Amidation

<400>  4

Met Thr Ala Asp Val 
1               5   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acylated-N terminus

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  C-Terminal Amidation

<400>  5

Met Thr Ala Asp Val Asp Arg 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acylated-N terminus

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  C-Terminal Amidation

<400>  6

Thr Arg Met Thr Ala Asp Val Asp Arg 
1               5                   


<210>  7
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Acylated-N terminus

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  C-Terminal Amidation

<400>  7

Thr Met Asp Val Ala Asp Arg 
1               5           


<210>  8
<211>  5748
<212>  DNA
<213>  Homo sapiens

<400>  8
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc actttgatga gcactagtgc tacagcaact gagacagcaa     1140

ccaagaggca agaaacctgg gattggtttt catggttgtt tctaccatca gagtcaaaga     1200

atcatcttca cacaacaaca caaatggctg gtacgtcttc aaataccatc tcagcaggct     1260

gggagccaaa tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag     1320

gcattgatga tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg     1380

accacacaaa acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag     1440

tgctacttca gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg     1500

aaggaaactg gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag     1560

aagagacccc acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa     1620

cagctaccca gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac     1680

ccaaagaaga ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc     1740

caatgcaagg aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc     1800

caatctcaca ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca     1860

gtcatagtat aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg     1920

acaggacagg acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat     1980

cacatgaagg cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca     2040

ataggaatga tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt     2100

tactggaagg ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag     2160

tgacctcagc taagactggg tcctttggag ttactgcagt tactgttgga gattccaact     2220

ctaatgtcaa tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc     2280

ataccactca tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa     2340

acacaacctc tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat     2400

ccctcttggc cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt     2460

gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc     2520

caagtggact caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg     2580

agtcgtcaga aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg     2640

tggacatgaa gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg     2700

aaacataacc attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt     2760

cattgcgaat cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct     2820

ttaaagtcag gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat     2880

aatcagcaag aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg     2940

ctatggatgg cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc     3000

accagctaag gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg     3060

ggtccatttt gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg     3120

ttggggtgta ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc     3180

tgggagacac ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg     3240

aaatattaaa ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag     3300

aggcacaaaa gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct     3360

tttgtgctgt gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag     3420

gaagagctga gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc     3480

cactcagacc cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt     3540

ttttgttttt tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat     3600

cagagttgga agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc     3660

ctgtgaaagg ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta     3720

tttcatagag gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg     3780

tcttacaata agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat     3840

gccatgtaga tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg     3900

tctgttcttg atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag     3960

gttaaaggga ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca     4020

agagagtact ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg     4080

gcatttattc atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca     4140

tagaagccat tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc     4200

tcctactaaa agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac     4260

cacaaagcag aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt     4320

tgatctgtag aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg     4380

ctcctccctg tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa     4440

aaacttcctt tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt     4500

ctttttattt tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact     4560

gccactagtg ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc     4620

agacaggctc actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca     4680

aaatggttac aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct     4740

catagccaga gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga     4800

ggttattttc aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc     4860

cctcacttgg atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt     4920

ccttggccat tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg     4980

aagtttatgg aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc     5040

acagcttgac tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt     5100

aaactgggtc tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag     5160

agctaaagat gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct     5220

taaaattagc tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc     5280

aagcctggta gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca     5340

taacaacacc aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga     5400

gtaggagaga ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat     5460

aacatggtcc attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag     5520

ttttcaaaga atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac     5580

tttgactttt cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa     5640

taatgaggaa agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa     5700

aaggctaaca ttaaaagact aaaggaaaca gaaaaaaaaa aaaaaaaa                  5748


<210>  9
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  10
<211>  2100
<212>  DNA
<213>  Homo sapiens

<400>  10
atggacaagt tttggtggca cgcagcctgg ggactctgcc tcgtgccgct gagcctggcg       60

cagatcgatt tgaatataac ctgccgcttt gcaggtgtat tccacgtgga gaaaaatggt      120

cgctacagca tctctcggac ggaggccgct gacctctgca aggctttcaa tagcaccttg      180

cccacaatgg cccagatgga gaaagctctg agcatcggat ttgagacctg caggtatggg      240

ttcatagaag ggcacgtggt gattccccgg atccacccca actccatctg tgcagcaaac      300

aacacagggg tgtacatcct cacatccaac acctcccagt atgacacata ttgcttcaat      360

gcttcagctc cacctgaaga agattgtaca tcagtcacag acctgcccaa tgcctttgat      420

ggaccaatta ccataactat tgttaaccgt gatggcaccc gctatgtcca gaaaggagaa      480

tacagaacga atcctgaaga catctacccc agcaacccta ctgatgatga cgtgagcagc      540

ggctcctcca gtgaaaggag cagcacttca ggaggttaca tcttttacac cttttctact      600

gtacacccca tcccagacga agacagtccc tggatcaccg acagcacaga cagaatccct      660

gctaccagta cgtcttcaaa taccatctca gcaggctggg agccaaatga agaaaatgaa      720

gatgaaagag acagacacct cagtttttct ggatcaggca ttgatgatga tgaagatttt      780

atctccagca ccatttcaac cacaccacgg gcttttgacc acacaaaaca gaaccaggac      840

tggacccagt ggaacccaag ccattcaaat ccggaagtgc tacttcagac aaccacaagg      900

atgactgcag atgtagacag aaatggcacc actgcttatg aaggaaactg gaacccagaa      960

gcacaccctc ccctcattca ccatgagcat catgaggaag aagagacccc acattctaca     1020

agcacaatcc aggcaactcc tagtagtaca acggaagaaa cagctaccca gaaggaacag     1080

tggtttggca acagatggca tgagggatat cgccaaacac ccagagaaga ctcccattcg     1140

acaacaggga cagctgcagc ctcagctcat accagccatc caatgcaagg aaggacaaca     1200

ccaagcccag aggacagttc ctggactgat ttcttcaacc caatctcaca ccccatggga     1260

cgaggtcatc aagcaggaag aaggatggat atggactcca gtcatagtac aacgcttcag     1320

cctactgcaa atccaaacac aggtttggtg gaagatttgg acaggacagg acctctttca     1380

atgacaacgc agcagagtaa ttctcagagc ttctctacat cacatgaagg cttggaagaa     1440

gataaagacc atccaacaac ttctactctg acatcaagca ataggaatga tgtcacaggt     1500

ggaagaagag acccaaatca ttctgaaggc tcaactactt tactggaagg ttatacctct     1560

cattacccac acacgaagga aagcaggacc ttcatcccag tgacctcagc taagactggg     1620

tcctttggag ttactgcagt tactgttgga gattccaact ctaatgtcaa tcgttcctta     1680

tcaggagacc aagacacatt ccaccccagt ggggggtccc ataccactca tggatctgaa     1740

tcagatggac actcacatgg gagtcaagaa ggtggagcaa acacaacctc tggtcctata     1800

aggacacccc aaattccaga atggctgatc atcttggcat ccctcttggc cttggctttg     1860

attcttgcag tttgcattgc agtcaacagt cgaagaaggt gtgggcagaa gaaaaagcta     1920

gtgatcaaca gtggcaatgg agctgtggag gacagaaagc caagtggact caacggagag     1980

gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg agtcgtcaga aactccagac     2040

cagtttatga cagctgatga gacaaggaac ctgcagaatg tggacatgaa gattggggtg     2100


<210>  11
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Ala Asp 
    290                 295                 300                 


Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu 
305                 310                 315                 320 


Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr 
                325                 330                 335     


Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu 
            340                 345                 350         


Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu 
        355                 360                 365             


Gly Tyr Arg Gln Thr Pro Arg Glu Asp Ser His Ser Thr Thr Gly Thr 
    370                 375                 380                 


Ala Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr 
385                 390                 395                 400 


Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser 
                405                 410                 415     


His Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp 
            420                 425                 430         


Ser Ser His Ser Thr Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly 
        435                 440                 445             


Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln 
    450                 455                 460                 


Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu 
465                 470                 475                 480 


Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn 
                485                 490                 495     


Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr 
            500                 505                 510         


Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser 
        515                 520                 525             


Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val 
    530                 535                 540                 


Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu 
545                 550                 555                 560 


Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr 
                565                 570                 575     


His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly 
            580                 585                 590         


Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp 
        595                 600                 605             


Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val 
    610                 615                 620                 


Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu 
625                 630                 635                 640 


Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly 
                645                 650                 655     


Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn 
            660                 665                 670         


Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr 
        675                 680                 685             


Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 700 


<210>  12
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcagggacc cgcagctcag ctacagcaca gatcagcacc atgaagcttc tcacgggcct       60

ggttttctgc tccttggtcc tgggtgtcag cagccgaagc ttcttttcgt tccttggcga      120

ggcttttgat ggggctcggg acatgtggag agcctactct gacatgagag aagccaatta      180

catcggctca gacaaatact tccatgctcg ggggaactat gatgctgcca aaaggggacc      240

tgggggtgcc tgggctgcag aagtgatcag cgatgccaga gagaatatcc agagattctt      300

tggccatggt gcggaggact cgctggctga tcaggctgcc aatgaatggg gcaggagtgg      360

caaagacccc aatcacttcc gacctgctgg cctgcctgag aaatactgag cttcctcttc      420

actctgctct caggagatct ggctgtgagg ccctcagggc agggatacaa agcggggaga      480

gggtacacaa tgggtatcta ataaatactt aagaggtgga atttgtggaa a               531


<210>  13
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  13
ggcagggacc cgcagctcag ctacagcaca gatcaggtga ggagcacacc aaggagtgat       60

ttttaaaact tactctgttt tctctttccc aacaagatta tcatttcctt taaaaaaaat      120

agttatcctg gggcatacag ccataccatt ctgaaggtgt cttatctcct ctgatctaga      180

gagcaccatg aagcttctca cgggcctggt tttctgctcc ttggtcctgg gtgtcagcag      240

ccgaagcttc ttttcgttcc ttggcgaggc ttttgatggg gctcgggaca tgtggagagc      300

ctactctgac atgagagaag ccaattacat cggctcagac aaatacttcc atgctcgggg      360

gaactatgat gctgccaaaa ggggacctgg gggtgcctgg gctgcagaag tgatcagcga      420

tgccagagag aatatccaga gattctttgg ccatggtgcg gaggactcgc tggctgatca      480

ggctgccaat gaatggggca ggagtggcaa agaccccaat cacttccgac ctgctggcct      540

gcctgagaaa tactgagctt cctcttcact ctgctctcag gagatctggc tgtgaggccc      600

tcagggcagg gatacaaagc ggggagaggg tacacaatgg gtatctaata aatacttaag      660

aggtggaatt tgtggaaa                                                    678


<210>  14
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  15
<211>  607
<212>  DNA
<213>  Mus musculus

<400>  15
atagatcacc agatctgccc aggagacacc aggatgaagc tactcaccag cctggtcttc       60

tgctccctgc tcctgggagt ctgccatgga gggttttttt catttgttca cgaggctttc      120

caaggggctg gggacatgtg gcgagcctac actgacatga aggaagctaa ctggaaaaac      180

tcagacaaat acttccatgc tcgggggaac tatgatgctg ctcaaagggg tcccggggga      240

gtctgggctg ctgagaaaat cagtgatgga agagaggcct ttcaggaatt cttcggcaga      300

ggacatgagg acaccattgc tgaccaggaa gccaacagac atggccgcag tggcaaagac      360

cccaattact acagacctcc tggactgcct gacaaatact gagcgtcctc ctattagctc      420

agtaggttgt gctgggggcc tgagggtggg gtctgggctt cttcctacct aggaacactg      480

aagatgctct ctggggaaac attgtatatc tctcatgtgt gtatcccaca agggtttcag      540

aactgagtta ctcttgcagt agtaactgct tgaggaggag agggtaataa acagaaactt      600

ggaagtg                                                                607


<210>  16
<211>  2053
<212>  DNA
<213>  Homo sapiens

<400>  16
aggctcacta taaatagcag ccacctctcc ctggcagaca gggacccgca gctcagctac       60

agcacagatc agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctgag      120

tgtcagcagc cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat      180

gtggagagcc tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca      240

tgctcggggg aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt      300

gatcagttta ttttcagctg aactgtagag agtgaaggaa gaagcctttt ttcttcactc      360

ctacatgacc caggcattga tccaggcaat gaagattcag tgtaaataac caccactaac      420

aagaccatgg cctttggaac ctgtgctaag aggcatggat gagctccctc agcatgtgga      480

tggagactga agagaggtct gaaggctcag tgtggtgtct ccattctcta agaagtttgg      540

aggagaagct ggatacagca aaacagactg agaaggagca gctgttggga aaggaggaaa      600

actaggaaag catggtgttc cagaatccct gatggagata ttgattagta gtatcagatt      660

ctgcttagca gttgaggagt tcacctttgg cttaagcaac atggagtcat tgactatctc      720

gtgaaggtgg ttgcaggaga aggtctggag aactaaatgg agcagtgata agagagaatg      780

ggagatggta tgataggact cctggacacc ccagacatca atcaaaacac cacagacaag      840

aaggtgtgga tacaaaaact agcagttaga agaaataata gaaaatgaac tccaactact      900

tctgaaaaaa aagtaatgag ggcaattaat acattgaaga aagcctcaat aagtacaaca      960

gtgtagtact gacttatata tagaaaaaac ctgatcagtg gaaccaaatc ctcagaatta     1020

gacataagtg catatgagaa ttttgtatgt gataaaggtt gtatgttaac gtattaagta     1080

aaagacggac tattcaacaa atgggattgg tacaactggg tgaccatcta aaataacatc     1140

atgttgaaaa catactgtat atattacggt aggacaaatt ccaaatatgc taaatattta     1200

taaacaaata aggaaaatga taataataat attaacatta tctggtgaat ccatggaaaa     1260

ttcttttata gcccaaagta gggaaagctg caacaacaag gatggaactg gaggtcatta     1320

tgctaagtga aatcattcag gaacagaaag acaaacatca catgttctca cttatttgtg     1380

ggatctaaaa atcaaaacaa ttgaattcat ggagatagag aatagaagga tggttaccag     1440

aggctgggaa gggtagtggg gaggggggga gtgaggggag gtgaggatgg ttaatgagta     1500

ccaaaaaaat acttagaatg aataagagct agtatttgat agcacaacgg gggactatag     1560

tcagtaataa tttagctgta cattgtaaaa taaccaaaag agtataattg gattatttgt     1620

aacacaaagg ataaatgctt gaggggatgg atacccaatt ttccatgatg tgattattgc     1680

gcattgcatg gctgtaccaa aatatctcat gtaccccata attatataca cctactatgt     1740

acccacaaaa aatttttaaa aaggaatgaa ataaaaacat ttgagtttaa gaaaaccaca     1800

aaaaaacaaa gtagggaaag ctcttcaaat actatgaaat tgagaagaca actaaagaaa     1860

atattaataa agacaagaac ataaataatt tctttggcag aacataagcc atcataatca     1920

gaagataaat aagctgggaa aaatatttgt aactcatatc ctagataaca tactcatttt     1980

ccctgtatat aaaaagtttc tctaatgtga taaataaaaa cacaataaac cagtaaaaaa     2040

tgaaaaaaaa aaa                                                        2053


<210>  17
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  17
aggctcacta taaatagcag ccacctctcc ctggcagaca gggacccgca gctcagctac       60

agcacagatc agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctgag      120

tgtcagcagc cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat      180

gtggagagcc tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca      240

tgctcggggg aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt      300

gatcagcaat gccagagaga atatccagag actcacaggc cgtggtgcgg aggactcgct      360

ggccgatcag gctgccaata aatggggcag gagtggcaga gaccccaatc acttccgacc      420

tgctggcctg cctgagaaat actgagcttc ctcttcactc tgctctcagg agacctggct      480

atgaggccct cggggcaggg atacaaagtt agtgaggtct atgtccagag aagctgagat      540

atggcatata ataggcatct aataaatgct taagaggtgg aatttgttga aaca            594


<210>  18
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  19
<211>  610
<212>  DNA
<213>  Mus musculus

<400>  19
atagaccacc agatctgccc aggagacacc agcaggatga agctactcac cagcctggtc       60

ttctgctccc tgctcctggg agtctgccat ggagggtttt tttcatttat tggggaggct      120

ttccaagggg ctggagacat gtggcgagcc tacactgaca tgaaggaagc tggctggaaa      180

gatggagaca aatacttcca tgctcggggg aactatgatg ctgcccaaag gggtcccggg      240

ggagtctggg ctgctgagaa aatcagtgat gcaagagaga gctttcagga attcttcggc      300

agaggacacg aggacaccat ggctgaccag gaagccaaca gacatggccg cagtggcaaa      360

gaccccaatt actacagacc tcctggactg cctgccaaat actgagagtc ctcctattag      420

ttcagaaggc tgtgttgggg tcctgagggt ggggtctggg cttcctatct aggaacactg      480

aagatgctct ctggggcaac atagtatacc tctcatgtgt gtatcccaca agggtttcag      540

aatggagtta ctcgagcagt agtaactgct tgaggaggag agggtaataa acaggaactt      600

ggaagtggat                                                             610


<210>  20
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  20
ggatttaaaa ccgttctccc attaatgcca aagccagcag aggtaccaac tatagctcca       60

cggccagaag ataccagcag ctctgccttt actgaaattt catctggaga aaggtccaca      120

gcacaatgag gcttttcaca ggcattgttt tctgctcctt ggtcatggga gtcaccagtg      180

aaagctggcg ttcgtttttc aaggaggctc tccaaggggt tggggacatg ggcagagcct      240

attgggacat aatgatatcc aatcaccaaa attcaaacag atatctctat gctcggggaa      300

actatgatgc tgcccaaaga ggacctgggg gtgtctgggc tgctaaactc atcagccgtt      360

ccagggtcta tcttcaggga ttaatagact gctatttatt tggaaacagc agcactgtat      420

tggaggactc gaagtccaac gagaaagctg aggaatgggg ccggagtggc aaagaccccg      480

accgcttcag acctgacggc ctgcctaaga aatactgagc ttcctgctcc tctgctctca      540

gggaaactgg gctgtgagcc acacacttct ccccccagac agggacacag ggtcactgag      600

ctttgtgtcc ccaggaactg gtatagggca cctagaggtg ttcaataaat gtttgtcaaa      660

ttgaaaaaaa aaaaa                                                       675


<210>  21
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  22
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  23
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  23
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc tgatggtcaa      240

agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg tgttcagaaa      300

ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt ctggagagct      360

gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg aaatagacac      420

caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag aggtggtatt      480

cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc      540

ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga      600

cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt actaaagcag      660

tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga      720

aaggcacttt tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa      780

aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa      840

cgctaggaga gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct      900

gcagccatta aaaagacaca ttctgtaaaa aaaaaaaa                              938


<210>  24
<211>  147
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Ser Leu Arg Leu Phe Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Ala Gly Ala Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val 
        35                  40                  45              


Ala Val Lys Val Phe Lys Lys Thr Ser Glu Gly Ser Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Asp Glu Lys Phe Val Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Thr Leu Gly Ile Ser Pro Phe His Glu Phe Ala Asp 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn 
    130                 135                 140                 


Pro Gln Asn 
145         


<210>  25
<211>  1237
<212>  DNA
<213>  Mus musculus

<400>  25
ctaatctccc taggcaaggt tcatatttgt gtaggttact tattctcctt ttgttgacta       60

agtcaataat cagaatcagc aggtttggag tcagcttggc agggatcagc agcctgggtt      120

ggaaggaggg ggtataaaag ccccttcacc aggagaagcc gtcacacaga tccacaagct      180

cctgacagga tggcttccct tcgactcttc ctcctttgcc tcgctggact ggtatttgtg      240

tctgaagctg gccccgcggg tgctggagaa tccaaatgtc ctctgatggt caaagtcctg      300

gatgctgtcc gaggcagccc tgctgtagac gtggctgtaa aagtgttcaa aaagacctct      360

gagggatcct gggagccctt tgcctctggg aagaccgcgg agtctggaga gctgcacggg      420

ctcaccacag atgagaagtt tgtagaagga gtgtacagag tagaactgga caccaaatcg      480

tactggaaga cacttggcat ttccccgttc catgaattcg cggatgtggt tttcacagcc      540

aacgactctg gccatcgcca ctacaccatc gcagccctgc tcagcccata ctcctacagc      600

accacggctg tcgtcagcaa cccccagaat tgagagactc agcccaggag gaccaggatc      660

ttgccaaagc agtagcatcc catttgtacc aaaacagtgt tcttgctcta taaaccgtgt      720

tagcagctca ggaagatgcc gtgaagcatt cttattaaac cacctgctat ttcattcaaa      780

ctgtgtttct tttttatttc ctcatttttc tcccctgctc ctaaaaccca aaatcttcta      840

aagaattcta gaaggtatgc gatcaaactt tttaaagaaa gaaaatactt tttgactcat      900

ggtttaaagg catcctttcc atcttgggga ggtcatgggt gctcctggca acttgcttga      960

ggaagatagg tcagaaagca gagtggacca accgttcaat gttttacaag caaaacatac     1020

actaagcatg gtctgtagct attaaaagca cacaatctga agggctgtag atgcacagta     1080

gtgttttccc agagcatgtt caaaagccct gggttcaatc acaatactga aaagtaggcc     1140

aaaaaacatt ctgaaaatga aatatttggg ttttttttta taacctttag tgactaaata     1200

aagacaaatc taagagacta aaaaaaaaaa aaaaaaa                              1237


<210>  26
<211>  4563
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  27
<211>  14121
<212>  DNA
<213>  Homo sapiens

<400>  27
attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg       60

cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc      120

agctggcgat ggacccgccg aggcccgcgc tgctggcgct gctggcgctg cctgcgctgc      180

tgctgctgct gctggcgggc gccagggccg aagaggaaat gctggaaaat gtcagcctgg      240

tctgtccaaa agatgcgacc cgattcaagc acctccggaa gtacacatac aactatgagg      300

ctgagagttc cagtggagtc cctgggactg ctgattcaag aagtgccacc aggatcaact      360

gcaaggttga gctggaggtt ccccagctct gcagcttcat cctgaagacc agccagtgca      420

ccctgaaaga ggtgtatggc ttcaaccctg agggcaaagc cttgctgaag aaaaccaaga      480

actctgagga gtttgctgca gccatgtcca ggtatgagct caagctggcc attccagaag      540

ggaagcaggt tttcctttac ccggagaaag atgaacctac ttacatcctg aacatcaaga      600

ggggcatcat ttctgccctc ctggttcccc cagagacaga agaagccaag caagtgttgt      660

ttctggatac cgtgtatgga aactgctcca ctcactttac cgtcaagacg aggaagggca      720

atgtggcaac agaaatatcc actgaaagag acctggggca gtgtgatcgc ttcaagccca      780

tccgcacagg catcagccca cttgctctca tcaaaggcat gacccgcccc ttgtcaactc      840

tgatcagcag cagccagtcc tgtcagtaca cactggacgc taagaggaag catgtggcag      900

aagccatctg caaggagcaa cacctcttcc tgcctttctc ctacaagaat aagtatggga      960

tggtagcaca agtgacacag actttgaaac ttgaagacac accaaagatc aacagccgct     1020

tctttggtga aggtactaag aagatgggcc tcgcatttga gagcaccaaa tccacatcac     1080

ctccaaagca ggccgaagct gttttgaaga ctctccagga actgaaaaaa ctaaccatct     1140

ctgagcaaaa tatccagaga gctaatctct tcaataagct ggttactgag ctgagaggcc     1200

tcagtgatga agcagtcaca tctctcttgc cacagctgat tgaggtgtcc agccccatca     1260

ctttacaagc cttggttcag tgtggacagc ctcagtgctc cactcacatc ctccagtggc     1320

tgaaacgtgt gcatgccaac ccccttctga tagatgtggt cacctacctg gtggccctga     1380

tccccgagcc ctcagcacag cagctgcgag agatcttcaa catggcgagg gatcagcgca     1440

gccgagccac cttgtatgcg ctgagccacg cggtcaacaa ctatcataag acaaacccta     1500

cagggaccca ggagctgctg gacattgcta attacctgat ggaacagatt caagatgact     1560

gcactgggga tgaagattac acctatttga ttctgcgggt cattggaaat atgggccaaa     1620

ccatggagca gttaactcca gaactcaagt cttcaatcct gaaatgtgtc caaagtacaa     1680

agccatcact gatgatccag aaagctgcca tccaggctct gcggaaaatg gagcctaaag     1740

acaaggacca ggaggttctt cttcagactt tccttgatga tgcttctccg ggagataagc     1800

gactggctgc ctatcttatg ttgatgagga gtccttcaca ggcagatatt aacaaaattg     1860

tccaaattct accatgggaa cagaatgagc aagtgaagaa ctttgtggct tcccatattg     1920

ccaatatctt gaactcagaa gaattggata tccaagatct gaaaaagtta gtgaaagaag     1980

ctctgaaaga atctcaactt ccaactgtca tggacttcag aaaattctct cggaactatc     2040

aactctacaa atctgtttct cttccatcac ttgacccagc ctcagccaaa atagaaggga     2100

atcttatatt tgatccaaat aactaccttc ctaaagaaag catgctgaaa actaccctca     2160

ctgcctttgg atttgcttca gctgacctca tcgagattgg cttggaagga aaaggctttg     2220

agccaacatt ggaagctctt tttgggaagc aaggattttt cccagacagt gtcaacaaag     2280

ctttgtactg ggttaatggt caagttcctg atggtgtctc taaggtctta gtggaccact     2340

ttggctatac caaagatgat aaacatgagc aggatatggt aaatggaata atgctcagtg     2400

ttgagaagct gattaaagat ttgaaatcca aagaagtccc ggaagccaga gcctacctcc     2460

gcatcttggg agaggagctt ggttttgcca gtctccatga cctccagctc ctgggaaagc     2520

tgcttctgat gggtgcccgc actctgcagg ggatccccca gatgattgga gaggtcatca     2580

ggaagggctc aaagaatgac ttttttcttc actacatctt catggagaat gcctttgaac     2640

tccccactgg agctggatta cagttgcaaa tatcttcatc tggagtcatt gctcccggag     2700

ccaaggctgg agtaaaactg gaagtagcca acatgcaggc tgaactggtg gcaaaaccct     2760

ccgtgtctgt ggagtttgtg acaaatatgg gcatcatcat tccggacttc gctaggagtg     2820

gggtccagat gaacaccaac ttcttccacg agtcgggtct ggaggctcat gttgccctaa     2880

aagctgggaa gctgaagttt atcattcctt ccccaaagag accagtcaag ctgctcagtg     2940

gaggcaacac attacatttg gtctctacca ccaaaacgga ggtgatccca cctctcattg     3000

agaacaggca gtcctggtca gtttgcaagc aagtctttcc tggcctgaat tactgcacct     3060

caggcgctta ctccaacgcc agctccacag actccgcctc ctactatccg ctgaccgggg     3120

acaccagatt agagctggaa ctgaggccta caggagagat tgagcagtat tctgtcagcg     3180

caacctatga gctccagaga gaggacagag ccttggtgga taccctgaag tttgtaactc     3240

aagcagaagg tgcgaagcag actgaggcta ccatgacatt caaatataat cggcagagta     3300

tgaccttgtc cagtgaagtc caaattccgg attttgatgt tgacctcgga acaatcctca     3360

gagttaatga tgaatctact gagggcaaaa cgtcttacag actcaccctg gacattcaga     3420

acaagaaaat tactgaggtc gccctcatgg gccacctaag ttgtgacaca aaggaagaaa     3480

gaaaaatcaa gggtgttatt tccatacccc gtttgcaagc agaagccaga agtgagatcc     3540

tcgcccactg gtcgcctgcc aaactgcttc tccaaatgga ctcatctgct acagcttatg     3600

gctccacagt ttccaagagg gtggcatggc attatgatga agagaagatt gaatttgaat     3660

ggaacacagg caccaatgta gataccaaaa aaatgacttc caatttccct gtggatctct     3720

ccgattatcc taagagcttg catatgtatg ctaatagact cctggatcac agagtccctc     3780

aaacagacat gactttccgg cacgtgggtt ccaaattaat agttgcaatg agctcatggc     3840

ttcagaaggc atctgggagt cttccttata cccagacttt gcaagaccac ctcaatagcc     3900

tgaaggagtt caacctccag aacatgggat tgccagactt ccacatccca gaaaacctct     3960

tcttaaaaag cgatggccgg gtcaaatata ccttgaacaa gaacagtttg aaaattgaga     4020

ttcctttgcc ttttggtggc aaatcctcca gagatctaaa gatgttagag actgttagga     4080

caccagccct ccacttcaag tctgtgggat tccatctgcc atctcgagag ttccaagtcc     4140

ctacttttac cattcccaag ttgtatcaac tgcaagtgcc tctcctgggt gttctagacc     4200

tctccacgaa tgtctacagc aacttgtaca actggtccgc ctcctacagt ggtggcaaca     4260

ccagcacaga ccatttcagc cttcgggctc gttaccacat gaaggctgac tctgtggttg     4320

acctgctttc ctacaatgtg caaggatctg gagaaacaac atatgaccac aagaatacgt     4380

tcacactatc atgtgatggg tctctacgcc acaaatttct agattcgaat atcaaattca     4440

gtcatgtaga aaaacttgga aacaacccag tctcaaaagg tttactaata ttcgatgcat     4500

ctagttcctg gggaccacag atgtctgctt cagttcattt ggactccaaa aagaaacagc     4560

atttgtttgt caaagaagtc aagattgatg ggcagttcag agtctcttcg ttctatgcta     4620

aaggcacata tggcctgtct tgtcagaggg atcctaacac tggccggctc aatggagagt     4680

ccaacctgag gtttaactcc tcctacctcc aaggcaccaa ccagataaca ggaagatatg     4740

aagatggaac cctctccctc acctccacct ctgatctgca aagtggcatc attaaaaata     4800

ctgcttccct aaagtatgag aactacgagc tgactttaaa atctgacacc aatgggaagt     4860

ataagaactt tgccacttct aacaagatgg atatgacctt ctctaagcaa aatgcactgc     4920

tgcgttctga atatcaggct gattacgagt cattgaggtt cttcagcctg ctttctggat     4980

cactaaattc ccatggtctt gagttaaatg ctgacatctt aggcactgac aaaattaata     5040

gtggtgctca caaggcgaca ctaaggattg gccaagatgg aatatctacc agtgcaacga     5100

ccaacttgaa gtgtagtctc ctggtgctgg agaatgagct gaatgcagag cttggcctct     5160

ctggggcatc tatgaaatta acaacaaatg gccgcttcag ggaacacaat gcaaaattca     5220

gtctggatgg gaaagccgcc ctcacagagc tatcactggg aagtgcttat caggccatga     5280

ttctgggtgt cgacagcaaa aacattttca acttcaaggt cagtcaagaa ggacttaagc     5340

tctcaaatga catgatgggc tcatatgctg aaatgaaatt tgaccacaca aacagtctga     5400

acattgcagg cttatcactg gacttctctt caaaacttga caacatttac agctctgaca     5460

agttttataa gcaaactgtt aatttacagc tacagcccta ttctctggta actactttaa     5520

acagtgacct gaaatacaat gctctggatc tcaccaacaa tgggaaacta cggctagaac     5580

ccctgaagct gcatgtggct ggtaacctaa aaggagccta ccaaaataat gaaataaaac     5640

acatctatgc catctcttct gctgccttat cagcaagcta taaagcagac actgttgcta     5700

aggttcaggg tgtggagttt agccatcggc tcaacacaga catcgctggg ctggcttcag     5760

ccattgacat gagcacaaac tataattcag actcactgca tttcagcaat gtcttccgtt     5820

ctgtaatggc cccgtttacc atgaccatcg atgcacatac aaatggcaat gggaaactcg     5880

ctctctgggg agaacatact gggcagctgt atagcaaatt cctgttgaaa gcagaacctc     5940

tggcatttac tttctctcat gattacaaag gctccacaag tcatcatctc gtgtctagga     6000

aaagcatcag tgcagctctt gaacacaaag tcagtgccct gcttactcca gctgagcaga     6060

caggcacctg gaaactcaag acccaattta acaacaatga atacagccag gacttggatg     6120

cttacaacac taaagataaa attggcgtgg agcttactgg acgaactctg gctgacctaa     6180

ctctactaga ctccccaatt aaagtgccac ttttactcag tgagcccatc aatatcattg     6240

atgctttaga gatgagagat gccgttgaga agccccaaga atttacaatt gttgcttttg     6300

taaagtatga taaaaaccaa gatgttcact ccattaacct cccatttttt gagaccttgc     6360

aagaatattt tgagaggaat cgacaaacca ttatagttgt actggaaaac gtacagagaa     6420

acctgaagca catcaatatt gatcaatttg taagaaaata cagagcagcc ctgggaaaac     6480

tcccacagca agctaatgat tatctgaatt cattcaattg ggagagacaa gtttcacatg     6540

ccaaggagaa actgactgct ctcacaaaaa agtatagaat tacagaaaat gatatacaaa     6600

ttgcattaga tgatgccaaa atcaacttta atgaaaaact atctcaactg cagacatata     6660

tgatacaatt tgatcagtat attaaagata gttatgattt acatgatttg aaaatagcta     6720

ttgctaatat tattgatgaa atcattgaaa aattaaaaag tcttgatgag cactatcata     6780

tccgtgtaaa tttagtaaaa acaatccatg atctacattt gtttattgaa aatattgatt     6840

ttaacaaaag tggaagtagt actgcatcct ggattcaaaa tgtggatact aagtaccaaa     6900

tcagaatcca gatacaagaa aaactgcagc agcttaagag acacatacag aatatagaca     6960

tccagcacct agctggaaag ttaaaacaac acattgaggc tattgatgtt agagtgcttt     7020

tagatcaatt gggaactaca atttcatttg aaagaataaa tgacgttctt gagcatgtca     7080

aacactttgt tataaatctt attggggatt ttgaagtagc tgagaaaatc aatgccttca     7140

gagccaaagt ccatgagtta atcgagaggt atgaagtaga ccaacaaatc caggttttaa     7200

tggataaatt agtagagttg gcccaccaat acaagttgaa ggagactatt cagaagctaa     7260

gcaatgtcct acaacaagtt aagataaaag attactttga gaaattggtt ggatttattg     7320

atgatgctgt caagaagctt aatgaattat cttttaaaac attcattgaa gatgttaaca     7380

aattccttga catgttgata aagaaattaa agtcatttga ttaccaccag tttgtagatg     7440

aaaccaatga caaaatccgt gaggtgactc agagactcaa tggtgaaatt caggctctgg     7500

aactaccaca aaaagctgaa gcattaaaac tgtttttaga ggaaaccaag gccacagttg     7560

cagtgtatct ggaaagccta caggacacca aaataacctt aatcatcaat tggttacagg     7620

aggctttaag ttcagcatct ttggctcaca tgaaggccaa attccgagag accctagaag     7680

atacacgaga ccgaatgtat caaatggaca ttcagcagga acttcaacga tacctgtctc     7740

tggtaggcca ggtttatagc acacttgtca cctacatttc tgattggtgg actcttgctg     7800

ctaagaacct tactgacttt gcagagcaat attctatcca agattgggct aaacgtatga     7860

aagcattggt agagcaaggg ttcactgttc ctgaaatcaa gaccatcctt gggaccatgc     7920

ctgcctttga agtcagtctt caggctcttc agaaagctac cttccagaca cctgatttta     7980

tagtccccct aacagatttg aggattccat cagttcagat aaacttcaaa gacttaaaaa     8040

atataaaaat cccatccagg ttttccacac cagaatttac catccttaac accttccaca     8100

ttccttcctt tacaattgac tttgtagaaa tgaaagtaaa gatcatcaga accattgacc     8160

agatgctgaa cagtgagctg cagtggcccg ttccagatat atatctcagg gatctgaagg     8220

tggaggacat tcctctagcg agaatcaccc tgccagactt ccgtttacca gaaatcgcaa     8280

ttccagaatt cataatccca actctcaacc ttaatgattt tcaagttcct gaccttcaca     8340

taccagaatt ccagcttccc cacatctcac acacaattga agtacctact tttggcaagc     8400

tatacagtat tctgaaaatc caatctcctc ttttcacatt agatgcaaat gctgacatag     8460

ggaatggaac cacctcagca aacgaagcag gtatcgcagc ttccatcact gccaaaggag     8520

agtccaaatt agaagttctc aattttgatt ttcaagcaaa tgcacaactc tcaaacccta     8580

agattaatcc gctggctctg aaggagtcag tgaagttctc cagcaagtac ctgagaacgg     8640

agcatgggag tgaaatgctg ttttttggaa atgctattga gggaaaatca aacacagtgg     8700

caagtttaca cacagaaaaa aatacactgg agcttagtaa tggagtgatt gtcaagataa     8760

acaatcagct taccctggat agcaacacta aatacttcca caaattgaac atccccaaac     8820

tggacttctc tagtcaggct gacctgcgca acgagatcaa gacactgttg aaagctggcc     8880

acatagcatg gacttcttct ggaaaagggt catggaaatg ggcctgcccc agattctcag     8940

atgagggaac acatgaatca caaattagtt tcaccataga aggacccctc acttcctttg     9000

gactgtccaa taagatcaat agcaaacacc taagagtaaa ccaaaacttg gtttatgaat     9060

ctggctccct caacttttct aaacttgaaa ttcaatcaca agtcgattcc cagcatgtgg     9120

gccacagtgt tctaactgct aaaggcatgg cactgtttgg agaagggaag gcagagttta     9180

ctgggaggca tgatgctcat ttaaatggaa aggttattgg aactttgaaa aattctcttt     9240

tcttttcagc ccagccattt gagatcacgg catccacaaa caatgaaggg aatttgaaag     9300

ttcgttttcc attaaggtta acagggaaga tagacttcct gaataactat gcactgtttc     9360

tgagtcccag tgcccagcaa gcaagttggc aagtaagtgc taggttcaat cagtataagt     9420

acaaccaaaa tttctctgct ggaaacaacg agaacattat ggaggcccat gtaggaataa     9480

atggagaagc aaatctggat ttcttaaaca ttcctttaac aattcctgaa atgcgtctac     9540

cttacacaat aatcacaact cctccactga aagatttctc tctatgggaa aaaacaggct     9600

tgaaggaatt cttgaaaacg acaaagcaat catttgattt aagtgtaaaa gctcagtata     9660

agaaaaacaa acacaggcat tccatcacaa atcctttggc tgtgctttgt gagtttatca     9720

gtcagagcat caaatccttt gacaggcatt ttgaaaaaaa cagaaacaat gcattagatt     9780

ttgtcaccaa atcctataat gaaacaaaaa ttaagtttga taagtacaaa gctgaaaaat     9840

ctcacgacga gctccccagg acctttcaaa ttcctggata cactgttcca gttgtcaatg     9900

ttgaagtgtc tccattcacc atagagatgt cggcattcgg ctatgtgttc ccaaaagcag     9960

tcagcatgcc tagtttctcc atcctaggtt ctgacgtccg tgtgccttca tacacattaa    10020

tcctgccatc attagagctg ccagtccttc atgtccctag aaatctcaag ctttctcttc    10080

cagatttcaa ggaattgtgt accataagcc atatttttat tcctgccatg ggcaatatta    10140

cctatgattt ctcctttaaa tcaagtgtca tcacactgaa taccaatgct gaacttttta    10200

accagtcaga tattgttgct catctccttt cttcatcttc atctgtcatt gatgcactgc    10260

agtacaaatt agagggcacc acaagattga caagaaaaag gggattgaag ttagccacag    10320

ctctgtctct gagcaacaaa tttgtggagg gtagtcataa cagtactgtg agcttaacca    10380

cgaaaaatat ggaagtgtca gtggcaacaa ccacaaaagc ccaaattcca attttgagaa    10440

tgaatttcaa gcaagaactt aatggaaata ccaagtcaaa acctactgtc tcttcctcca    10500

tggaatttaa gtatgatttc aattcttcaa tgctgtactc taccgctaaa ggagcagttg    10560

accacaagct tagcttggaa agcctcacct cttacttttc cattgagtca tctaccaaag    10620

gagatgtcaa gggttcggtt ctttctcggg aatattcagg aactattgct agtgaggcca    10680

acacttactt gaattccaag agcacacggt cttcagtgaa gctgcagggc acttccaaaa    10740

ttgatgatat ctggaacctt gaagtaaaag aaaattttgc tggagaagcc acactccaac    10800

gcatatattc cctctgggag cacagtacga aaaaccactt acagctagag ggcctctttt    10860

tcaccaacgg agaacataca agcaaagcca ccctggaact ctctccatgg caaatgtcag    10920

ctcttgttca ggtccatgca agtcagccca gttccttcca tgatttccct gaccttggcc    10980

aggaagtggc cctgaatgct aacactaaga accagaagat cagatggaaa aatgaagtcc    11040

ggattcattc tgggtctttc cagagccagg tcgagctttc caatgaccaa gaaaaggcac    11100

accttgacat tgcaggatcc ttagaaggac acctaaggtt cctcaaaaat atcatcctac    11160

cagtctatga caagagctta tgggatttcc taaagctgga tgtaaccacc agcattggta    11220

ggagacagca tcttcgtgtt tcaactgcct ttgtgtacac caaaaacccc aatggctatt    11280

cattctccat ccctgtaaaa gttttggctg ataaattcat tattcctggg ctgaaactaa    11340

atgatctaaa ttcagttctt gtcatgccta cgttccatgt cccatttaca gatcttcagg    11400

ttccatcgtg caaacttgac ttcagagaaa tacaaatcta taagaagctg agaacttcat    11460

catttgccct caacctacca acactccccg aggtaaaatt ccctgaagtt gatgtgttaa    11520

caaaatattc tcaaccagaa gactccttga ttcccttttt tgagataacc gtgcctgaat    11580

ctcagttaac tgtgtcccag ttcacgcttc caaaaagtgt ttcagatggc attgctgctt    11640

tggatctaaa tgcagtagcc aacaagatcg cagactttga gttgcccacc atcatcgtgc    11700

ctgagcagac cattgagatt ccctccatta agttctctgt acctgctgga attgtcattc    11760

cttcctttca agcactgact gcacgctttg aggtagactc tcccgtgtat aatgccactt    11820

ggagtgccag tttgaaaaac aaagcagatt atgttgaaac agtcctggat tccacatgca    11880

gctcaaccgt acagttccta gaatatgaac taaatgtttt gggaacacac aaaatcgaag    11940

atggtacgtt agcctctaag actaaaggaa catttgcaca ccgtgacttc agtgcagaat    12000

atgaagaaga tggcaaatat gaaggacttc aggaatggga aggaaaagcg cacctcaata    12060

tcaaaagccc agcgttcacc gatctccatc tgcgctacca gaaagacaag aaaggcatct    12120

ccacctcagc agcctcccca gccgtaggca ccgtgggcat ggatatggat gaagatgacg    12180

acttttctaa atggaacttc tactacagcc ctcagtcctc tccagataaa aaactcacca    12240

tattcaaaac tgagttgagg gtccgggaat ctgatgagga aactcagatc aaagttaatt    12300

gggaagaaga ggcagcttct ggcttgctaa cctctctgaa agacaacgtg cccaaggcca    12360

caggggtcct ttatgattat gtcaacaagt accactggga acacacaggg ctcaccctga    12420

gagaagtgtc ttcaaagctg agaagaaatc tgcagaacaa tgctgagtgg gtttatcaag    12480

gggccattag gcaaattgat gatatcgacg tgaggttcca gaaagcagcc agtggcacca    12540

ctgggaccta ccaagagtgg aaggacaagg cccagaatct gtaccaggaa ctgttgactc    12600

aggaaggcca agccagtttc cagggactca aggataacgt gtttgatggc ttggtacgag    12660

ttactcaaga attccatatg aaagtcaagc atctgattga ctcactcatt gattttctga    12720

acttccccag attccagttt ccggggaaac ctgggatata cactagggag gaactttgca    12780

ctatgttcat aagggaggta gggacggtac tgtcccaggt atattcgaaa gtccataatg    12840

gttcagaaat actgttttcc tatttccaag acctagtgat tacacttcct ttcgagttaa    12900

ggaaacataa actaatagat gtaatctcga tgtataggga actgttgaaa gatttatcaa    12960

aagaagccca agaggtattt aaagccattc agtctctcaa gaccacagag gtgctacgta    13020

atcttcagga ccttttacaa ttcattttcc aactaataga agataacatt aaacagctga    13080

aagagatgaa atttacttat cttattaatt atatccaaga tgagatcaac acaatcttca    13140

gtgattatat cccatatgtt tttaaattgt tgaaagaaaa cctatgcctt aatcttcata    13200

agttcaatga atttattcaa aacgagcttc aggaagcttc tcaagagtta cagcagatcc    13260

atcaatacat tatggccctt cgtgaagaat attttgatcc aagtatagtt ggctggacag    13320

tgaaatatta tgaacttgaa gaaaagatag tcagtctgat caagaacctg ttagttgctc    13380

ttaaggactt ccattctgaa tatattgtca gtgcctctaa ctttacttcc caactctcaa    13440

gtcaagttga gcaatttctg cacagaaata ttcaggaata tcttagcatc cttaccgatc    13500

cagatggaaa agggaaagag aagattgcag agctttctgc cactgctcag gaaataatta    13560

aaagccaggc cattgcgacg aagaaaataa tttctgatta ccaccagcag tttagatata    13620

aactgcaaga tttttcagac caactctctg attactatga aaaatttatt gctgaatcca    13680

aaagattgat tgacctgtcc attcaaaact accacacatt tctgatatac atcacggagt    13740

tactgaaaaa gctgcaatca accacagtca tgaaccccta catgaagctt gctccaggag    13800

aacttactat catcctctaa ttttttaaaa gaaatcttca tttattcttc ttttccaatt    13860

gaactttcac atagcacaga aaaaattcaa actgcctata ttgataaaac catacagtga    13920

gccagccttg cagtaggcag tagactataa gcagaagcac atatgaactg gacctgcacc    13980

aaagctggca ccagggctcg gaaggtctct gaactcagaa ggatggcatt ttttgcaagt    14040

taaagaaaat caggatctga gttattttgc taaacttggg ggaggaggaa caaataaatg    14100

gagtctttat tgtgtatcat a                                              14121


<210>  28
<211>  4505
<212>  PRT
<213>  Mus musculus

<400>  28

Met Gly Pro Arg Lys Pro Ala Leu Arg Thr Pro Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Leu Phe Leu Asp Thr Ser Val Trp Ala Gln Asp Glu Val Leu 
            20                  25                  30          


Glu Asn Leu Ser Phe Ser Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Val Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Gln Gly Thr Ala Asp Ser Arg Ser Ala Thr Lys Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Ile Cys Gly Phe Ile Met Arg Thr Asn Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Met Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Ile Val Leu Tyr 
    130                 135                 140                 


Pro Asp Lys Asp Glu Pro Lys Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Asp Gln Gln Glu 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr Gln Val Thr Val 
            180                 185                 190         


Asn Ser Arg Lys Gly Thr Val Pro Thr Glu Met Ser Thr Glu Arg Asn 
        195                 200                 205             


Leu Gln Gln Cys Asp Gly Phe Gln Pro Ile Ser Thr Ser Val Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Leu Val His Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Thr Cys Gln Tyr Thr Leu Asp Pro Lys Arg Lys His Val 
                245                 250                 255     


Ser Glu Ala Val Cys Asp Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Ile Met Thr Arg Val Thr Gln Lys Leu Ser Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Ser Glu Gly Thr Asn 
    290                 295                 300                 


Arg Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Ser Pro Lys 
305                 310                 315                 320 


Gln Ala Asp Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Ser 
                325                 330                 335     


Ile Ser Glu Gln Asn Ala Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Thr Gly Glu Ala Ile Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Tyr Thr His Ile Leu Gln Trp Leu Lys Thr 
385                 390                 395                 400 


Glu Lys Ala His Pro Leu Leu Val Asp Ile Val Thr Tyr Leu Met Ala 
                405                 410                 415     


Leu Ile Pro Asn Pro Ser Thr Gln Arg Leu Gln Glu Ile Phe Asn Thr 
            420                 425                 430         


Ala Lys Glu Gln Gln Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Ser Tyr Phe Asp Val Asp His Ser Arg Ser Pro Val Leu Gln 
    450                 455                 460                 


Asp Ile Ala Gly Tyr Leu Leu Lys Gln Ile Asp Asn Glu Cys Thr Gly 
465                 470                 475                 480 


Asn Glu Asp His Thr Phe Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Arg Thr Met Glu Gln Val Met Pro Ala Leu Lys Ser Ser Val Leu Ser 
            500                 505                 510         


Cys Val Arg Ser Thr Lys Pro Ser Leu Leu Ile Gln Lys Ala Ala Leu 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Leu Glu Asp Glu Val Arg Thr Ile Leu 
    530                 535                 540                 


Phe Asp Thr Phe Val Asn Gly Val Ala Pro Val Glu Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Leu Leu Met Lys Asn Pro Ser Ser Ser Asp Ile Asn Lys 
                565                 570                 575     


Ile Ala Gln Leu Leu Gln Trp Glu Gln Ser Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Tyr Val 
        595                 600                 605             


Gln Asp Leu Lys Val Leu Ile Lys Asn Ala Leu Glu Asn Ser Gln Phe 
    610                 615                 620                 


Pro Thr Ile Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Ile Ser 
625                 630                 635                 640 


Lys Ser Ala Ser Leu Pro Met Phe Asp Pro Val Ser Val Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Ser Ser Tyr Leu Pro Arg Glu Ser Leu 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Val Phe Gly Leu Ala Ser Leu Asp Leu Phe 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Arg Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Thr Asp Gly Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Pro Ile Val Asp Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Ile Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Lys Glu Leu 
    770                 775                 780                 


Ser Phe Val Arg Leu Gln Asp Leu Gln Val Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Ser Gly Ala Gln Thr Leu Gln Gly Ile Pro Gln Met Val Val Gln Ala 
                805                 810                 815     


Ile Arg Glu Gly Ser Lys Asn Asp Leu Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Asp Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Val 
        835                 840                 845             


Ser Ser Ser Gly Val Phe Thr Pro Gly Ile Lys Ala Gly Val Arg Leu 
    850                 855                 860                 


Glu Leu Ala Asn Ile Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Leu Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Lys 
                885                 890                 895     


Ser Ser Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala Arg Val Ala Leu Lys Ala Gly Gln Leu Lys Val Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Phe Ser Gly Ser Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Val Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Thr Cys Lys Pro Leu Phe Thr Gly Met Asn Tyr Cys 
                965                 970                 975     


Thr Thr Gly Ala Tyr Ser Asn Ala Ser Ser Thr Glu Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Tyr Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Val Glu Gln Tyr Ser  Ala Thr Ala Thr Tyr  Glu Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asp Lys Ser Leu Val  Asp Thr Leu Lys Phe  Leu Val Gln 
    1025                 1030                 1035             


Ala Glu  Gly Val Gln Gln Ser  Glu Ala Thr Val Leu  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Arg Ser Arg Thr Leu  Ser Ser Glu Val Leu  Ile Pro Gly 
    1055                 1060                 1065             


Phe Asp  Val Asn Phe Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Ala Lys  Asp Lys Asn Thr Tyr  Lys Leu Ile Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ser  Leu Val Gly His Leu  Ser Tyr Asp 
    1100                 1105                 1110             


Lys Lys  Gly Asp Gly Lys Ile  Lys Gly Val Val Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Val His Thr His  Trp Ser Ser 
    1130                 1135                 1140             


Thr Lys  Leu Leu Phe Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Ile Ser Lys Arg Val  Thr Trp Arg Tyr Asp  Asn Glu Ile 
    1160                 1165                 1170             


Ile Glu  Phe Asp Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Val Ala  Ser Asn Phe Pro Val  Asp Leu Ser His Tyr  Pro Arg Met 
    1190                 1195                 1200             


Leu His  Glu Tyr Ala Asn Gly  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Val Thr Phe Arg Asp  Met Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Thr Asn  Thr Trp Leu Gln Met  Ala Thr Arg Gly Leu  Pro Tyr Pro 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Ser Glu  Leu Asn Leu 
    1250                 1255                 1260             


Leu Lys  Met Gly Leu Ser Asp  Phe His Ile Pro Asp  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Thr Asp Gly Arg Val  Lys Tyr Thr Met Asn  Arg Asn Lys 
    1280                 1285                 1290             


Ile Asn  Ile Asp Ile Pro Leu  Pro Leu Gly Gly Lys  Ser Ser Lys 
    1295                 1300                 1305             


Asp Leu  Lys Met Pro Glu Ser  Val Arg Thr Pro Ala  Leu Asn Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Val  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Thr  His Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Thr Gly  Gly Asn Thr Ser Arg  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Gln Ala Gln Tyr Arg  Met Lys Thr Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Phe  Ser Tyr Ser Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


Ser Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu His His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Lys Phe  Lys Val Ser His Val  Glu Lys Phe 
    1430                 1435                 1440             


Gly Asn  Ser Pro Val Ser Lys  Gly Leu Leu Thr Phe  Glu Thr Ser 
    1445                 1450                 1455             


Ser Ala  Leu Gly Pro Gln Met  Ser Ala Thr Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Tyr  Val Lys Asp Ile Lys  Val Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Ala Ser Ser Phe  Tyr Ala Gln Gly Lys  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Glu Arg Asp Val Thr  Thr Gly Gln Leu Ser  Gly Glu Ser 
    1505                 1510                 1515             


Asn Met  Arg Phe Asn Ser Thr  Tyr Phe Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Val Gly  Met Tyr Gln Asp Gly  Ala Leu Ser Ile Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Asp Gly Ile Phe  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Ser Ser  Gly Gln Tyr 
    1565                 1570                 1575             


Glu Asn  Phe Ala Ala Ser Asn  Lys Leu Asp Val Thr  Phe Ser Thr 
    1580                 1585                 1590             


Gln Ser  Ala Leu Leu Arg Ser  Glu His Gln Ala Asn  Tyr Lys Ser 
    1595                 1600                 1605             


Leu Arg  Leu Val Thr Leu Leu  Ser Gly Ser Leu Thr  Ser Gln Gly 
    1610                 1615                 1620             


Val Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Thr 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Lys Ile Ala Arg Asp  Gly Leu Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Tyr Ser Pro Leu  Leu Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Ser  Thr Asn Gly Arg Phe  Lys Glu His His Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Arg Ala Ala Leu  Thr Glu Val Ser Leu  Gly Ser Ile 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Ala Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Leu Ser Arg Glu Gly  Leu Arg Leu Ser Asn  Asp Leu Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Leu Asp His Thr His  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Phe Ser Lys Met  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Gly Asp Lys Phe Tyr  Lys Gln Asn Phe Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Phe Ile Thr  Thr Leu Ser Asn Asp  Leu Arg Tyr 
    1790                 1795                 1800             


Gly Ala  Leu Asp Leu Thr Asn  Asn Gly Arg Phe Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu Asn Val Gly Gly  Asn Phe Lys Gly Thr  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Leu Lys His Ile Tyr  Thr Ile Ser Tyr Thr  Asp Leu Val 
    1835                 1840                 1845             


Val Ala  Ser Tyr Arg Ala Asp  Thr Val Ala Lys Val  Gln Gly Val 
    1850                 1855                 1860             


Glu Phe  Ser His Arg Leu Asn  Ala Asp Ile Glu Gly  Leu Thr Ser 
    1865                 1870                 1875             


Ser Val  Asp Val Thr Thr Ser  Tyr Asn Ser Asp Pro  Leu His Phe 
    1880                 1885                 1890             


Asn Asn  Val Phe His Phe Ser  Leu Ala Pro Phe Thr  Leu Gly Ile 
    1895                 1900                 1905             


Asp Thr  His Thr Ser Gly Asp  Gly Lys Leu Ser Phe  Trp Gly Glu 
    1910                 1915                 1920             


His Thr  Gly Gln Leu Tyr Ser  Lys Phe Leu Leu Lys  Ala Glu Pro 
    1925                 1930                 1935             


Leu Ala  Leu Ile Val Ser His  Asp Tyr Lys Gly Ser  Thr Ser His 
    1940                 1945                 1950             


Ser Leu  Pro Tyr Glu Ser Ser  Ile Ser Thr Ala Leu  Glu His Thr 
    1955                 1960                 1965             


Val Ser  Ala Leu Leu Thr Pro  Ala Glu Gln Thr Ser  Thr Trp Lys 
    1970                 1975                 1980             


Phe Lys  Thr Lys Leu Asn Asp  Lys Val Tyr Ser Gln  Asp Phe Glu 
    1985                 1990                 1995             


Ala Tyr  Asn Thr Lys Asp Lys  Ile Gly Val Glu Leu  Ser Gly Arg 
    2000                 2005                 2010             


Ala Asp  Leu Ser Gly Leu Tyr  Ser Pro Ile Lys Leu  Pro Phe Phe 
    2015                 2020                 2025             


Tyr Ser  Glu Pro Val Asn Val  Leu Asn Gly Leu Glu  Val Asn Asp 
    2030                 2035                 2040             


Ala Val  Asp Lys Pro Gln Glu  Phe Thr Ile Ile Ala  Val Val Lys 
    2045                 2050                 2055             


Tyr Asp  Lys Asn Gln Asp Val  His Thr Ile Asn Leu  Pro Phe Phe 
    2060                 2065                 2070             


Lys Ser  Leu Pro Asp Tyr Leu  Glu Arg Asn Arg Arg  Gly Met Ile 
    2075                 2080                 2085             


Ser Leu  Leu Glu Ala Met Arg  Gly Glu Leu Gln Arg  Leu Ser Val 
    2090                 2095                 2100             


Asp Gln  Phe Val Arg Lys Tyr  Arg Ala Ala Leu Ser  Arg Leu Pro 
    2105                 2110                 2115             


Gln Gln  Ile His His Tyr Leu  Asn Ala Ser Asp Trp  Glu Arg Gln 
    2120                 2125                 2130             


Val Ala  Gly Ala Lys Glu Lys  Ile Thr Ser Phe Met  Glu Asn Tyr 
    2135                 2140                 2145             


Arg Ile  Thr Asp Asn Asp Val  Leu Ile Ala Ile Asp  Ser Ala Lys 
    2150                 2155                 2160             


Ile Asn  Phe Asn Glu Lys Leu  Ser Gln Leu Glu Thr  Tyr Ala Ile 
    2165                 2170                 2175             


Gln Phe  Asp Gln Tyr Ile Lys  Asp Asn Tyr Asp Pro  His Asp Leu 
    2180                 2185                 2190             


Lys Arg  Thr Ile Ala Glu Ile  Ile Asp Arg Ile Ile  Glu Lys Leu 
    2195                 2200                 2205             


Lys Ile  Leu Asp Glu Gln Tyr  His Ile Arg Val Asn  Leu Ala Lys 
    2210                 2215                 2220             


Ser Ile  His Asn Leu Tyr Leu  Phe Val Glu Asn Val  Asp Leu Asn 
    2225                 2230                 2235             


Gln Val  Ser Ser Ser Asn Thr  Ser Trp Ile Gln Asn  Val Asp Ser 
    2240                 2245                 2250             


Asn Tyr  Gln Val Arg Ile Gln  Ile Gln Glu Lys Leu  Gln Gln Leu 
    2255                 2260                 2265             


Arg Thr  Gln Ile Gln Asn Ile  Asp Ile Gln Gln Leu  Ala Ala Glu 
    2270                 2275                 2280             


Val Lys  Arg Gln Met Asp Ala  Ile Asp Val Thr Met  His Leu Asp 
    2285                 2290                 2295             


Gln Leu  Arg Thr Ala Ile Leu  Phe Gln Arg Ile Ser  Asp Ile Ile 
    2300                 2305                 2310             


Asp Arg  Val Lys Tyr Phe Val  Met Asn Leu Ile Glu  Asp Phe Lys 
    2315                 2320                 2325             


Val Thr  Glu Lys Ile Asn Thr  Phe Arg Val Ile Val  Arg Glu Leu 
    2330                 2335                 2340             


Ile Glu  Lys Tyr Glu Val Asp  Gln His Ile Gln Val  Leu Met Asp 
    2345                 2350                 2355             


Lys Ser  Val Glu Leu Ala His  Arg Tyr Ser Leu Ser  Glu Pro Leu 
    2360                 2365                 2370             


Gln Lys  Leu Ser Asn Val Leu  Gln Arg Ile Glu Ile  Lys Asp Tyr 
    2375                 2380                 2385             


Tyr Glu  Lys Leu Val Gly Phe  Ile Asp Asp Thr Val  Glu Trp Leu 
    2390                 2395                 2400             


Lys Ala  Leu Ser Phe Lys Asn  Thr Ile Glu Glu Leu  Asn Arg Leu 
    2405                 2410                 2415             


Thr Asp  Met Leu Val Lys Lys  Leu Lys Ala Phe Asp  Tyr His Gln 
    2420                 2425                 2430             


Phe Val  Asp Lys Thr Asn Ser  Lys Ile Arg Glu Met  Thr Gln Arg 
    2435                 2440                 2445             


Ile Asn  Ala Glu Ile Gln Ala  Leu Lys Leu Pro Gln  Lys Met Glu 
    2450                 2455                 2460             


Ala Leu  Lys Leu Leu Val Glu  Asp Phe Lys Thr Thr  Val Ser Asn 
    2465                 2470                 2475             


Ser Leu  Glu Arg Leu Lys Asp  Thr Lys Val Thr Val  Val Ile Asp 
    2480                 2485                 2490             


Trp Leu  Gln Asp Ile Leu Thr  Gln Met Lys Asp His  Phe Gln Asp 
    2495                 2500                 2505             


Thr Leu  Glu Asp Val Arg Asp  Arg Ile Tyr Gln Met  Asp Ile Gln 
    2510                 2515                 2520             


Arg Glu  Leu Glu His Phe Leu  Ser Leu Val Asn Gln  Val Tyr Ser 
    2525                 2530                 2535             


Thr Leu  Val Thr Tyr Met Ser  Asp Trp Trp Thr Leu  Thr Ala Lys 
    2540                 2545                 2550             


Asn Ile  Thr Asp Phe Ala Glu  Gln Tyr Ser Ile Gln  Asn Trp Ala 
    2555                 2560                 2565             


Glu Ser  Ile Lys Val Leu Val  Glu Gln Gly Phe Ile  Val Pro Glu 
    2570                 2575                 2580             


Met Gln  Thr Phe Leu Trp Thr  Met Pro Ala Phe Glu  Val Ser Leu 
    2585                 2590                 2595             


Arg Ala  Leu Gln Glu Gly Asn  Phe Gln Thr Pro Val  Phe Ile Val 
    2600                 2605                 2610             


Pro Leu  Thr Asp Leu Arg Ile  Pro Ser Ile Arg Ile  Asn Phe Lys 
    2615                 2620                 2625             


Met Leu  Lys Asn Ile Lys Ile  Pro Leu Arg Phe Ser  Thr Pro Glu 
    2630                 2635                 2640             


Phe Thr  Leu Leu Asn Thr Phe  His Val His Ser Phe  Thr Ile Asp 
    2645                 2650                 2655             


Leu Leu  Glu Ile Lys Ala Lys  Ile Ile Arg Thr Ile  Asp Gln Ile 
    2660                 2665                 2670             


Leu Ser  Ser Glu Leu Gln Trp  Pro Leu Pro Glu Met  Tyr Leu Arg 
    2675                 2680                 2685             


Asp Leu  Asp Val Val Asn Ile  Pro Leu Ala Arg Leu  Thr Leu Pro 
    2690                 2695                 2700             


Asp Phe  His Val Pro Glu Ile  Thr Ile Pro Glu Phe  Thr Ile Pro 
    2705                 2710                 2715             


Asn Val  Asn Leu Lys Asp Leu  His Val Pro Asp Leu  His Ile Pro 
    2720                 2725                 2730             


Glu Phe  Gln Leu Pro His Leu  Ser His Thr Ile Glu  Ile Pro Ala 
    2735                 2740                 2745             


Phe Gly  Lys Leu His Ser Ile  Leu Lys Ile Gln Ser  Pro Leu Phe 
    2750                 2755                 2760             


Ile Leu  Asp Ala Asn Ala Asn  Ile Gln Asn Val Thr  Thr Ser Gly 
    2765                 2770                 2775             


Asn Lys  Ala Glu Ile Val Ala  Ser Val Thr Ala Lys  Gly Glu Ser 
    2780                 2785                 2790             


Gln Phe  Glu Ala Leu Asn Phe  Asp Phe Gln Ala Gln  Ala Gln Phe 
    2795                 2800                 2805             


Leu Glu  Leu Asn Pro His Pro  Pro Val Leu Lys Glu  Ser Met Asn 
    2810                 2815                 2820             


Phe Ser  Ser Lys His Val Arg  Met Glu His Glu Gly  Glu Ile Val 
    2825                 2830                 2835             


Phe Asp  Gly Lys Ala Ile Glu  Gly Lys Ser Asp Thr  Val Ala Ser 
    2840                 2845                 2850             


Leu His  Thr Glu Lys Asn Glu  Val Glu Phe Asn Asn  Gly Met Thr 
    2855                 2860                 2865             


Val Lys  Val Asn Asn Gln Leu  Thr Leu Asp Ser His  Thr Lys Tyr 
    2870                 2875                 2880             


Phe His  Lys Leu Ser Val Pro  Arg Leu Asp Phe Ser  Ser Lys Ala 
    2885                 2890                 2895             


Ser Leu  Asn Asn Glu Ile Lys  Thr Leu Leu Glu Ala  Gly His Val 
    2900                 2905                 2910             


Ala Leu  Thr Ser Ser Gly Thr  Gly Ser Trp Asn Trp  Ala Cys Pro 
    2915                 2920                 2925             


Asn Phe  Ser Asp Glu Gly Ile  His Ser Ser Gln Ile  Ser Phe Thr 
    2930                 2935                 2940             


Val Asp  Gly Pro Ile Ala Phe  Val Gly Leu Ser Asn  Asn Ile Asn 
    2945                 2950                 2955             


Gly Lys  His Leu Arg Val Ile  Gln Lys Leu Thr Tyr  Glu Ser Gly 
    2960                 2965                 2970             


Phe Leu  Asn Tyr Ser Lys Phe  Glu Val Glu Ser Lys  Val Glu Ser 
    2975                 2980                 2985             


Gln His  Val Gly Ser Ser Ile  Leu Thr Ala Asn Gly  Arg Ala Leu 
    2990                 2995                 3000             


Leu Lys  Asp Ala Lys Ala Glu  Met Thr Gly Glu His  Asn Ala Asn 
    3005                 3010                 3015             


Leu Asn  Gly Lys Val Ile Gly  Thr Leu Lys Asn Ser  Leu Phe Phe 
    3020                 3025                 3030             


Ser Ala  Gln Pro Phe Glu Ile  Thr Ala Ser Thr Asn  Asn Glu Gly 
    3035                 3040                 3045             


Asn Leu  Lys Val Gly Phe Pro  Leu Lys Leu Thr Gly  Lys Ile Asp 
    3050                 3055                 3060             


Phe Leu  Asn Asn Tyr Ala Leu  Phe Leu Ser Pro Arg  Ala Gln Gln 
    3065                 3070                 3075             


Ala Ser  Trp Gln Ala Ser Thr  Arg Phe Asn Gln Tyr  Lys Tyr Asn 
    3080                 3085                 3090             


Gln Asn  Phe Ser Ala Ile Asn  Asn Glu His Asn Ile  Glu Ala Ser 
    3095                 3100                 3105             


Ile Gly  Met Asn Gly Asp Ala  Asn Leu Asp Phe Leu  Asn Ile Pro 
    3110                 3115                 3120             


Leu Thr  Ile Pro Glu Ile Asn  Leu Pro Tyr Thr Glu  Phe Lys Thr 
    3125                 3130                 3135             


Pro Leu  Leu Lys Asp Phe Ser  Ile Trp Glu Glu Thr  Gly Leu Lys 
    3140                 3145                 3150             


Glu Phe  Leu Lys Thr Thr Lys  Gln Ser Phe Asp Leu  Ser Val Lys 
    3155                 3160                 3165             


Ala Gln  Tyr Lys Lys Asn Ser  Asp Lys His Ser Ile  Val Val Pro 
    3170                 3175                 3180             


Leu Gly  Met Phe Tyr Glu Phe  Ile Leu Asn Asn Val  Asn Ser Trp 
    3185                 3190                 3195             


Asp Arg  Lys Phe Glu Lys Val  Arg Asn Asn Ala Leu  His Phe Leu 
    3200                 3205                 3210             


Thr Thr  Ser Tyr Asn Glu Ala  Lys Ile Lys Val Asp  Lys Tyr Lys 
    3215                 3220                 3225             


Thr Glu  Asn Ser Leu Asn Gln  Pro Ser Gly Thr Phe  Gln Asn His 
    3230                 3235                 3240             


Gly Tyr  Thr Ile Pro Val Val  Asn Ile Glu Val Ser  Pro Phe Ala 
    3245                 3250                 3255             


Val Glu  Thr Leu Ala Ser Ser  His Val Ile Pro Thr  Ala Ile Ser 
    3260                 3265                 3270             


Thr Pro  Ser Val Thr Ile Pro  Gly Pro Asn Ile Met  Val Pro Ser 
    3275                 3280                 3285             


Tyr Lys  Leu Val Leu Pro Pro  Leu Glu Leu Pro Val  Phe His Gly 
    3290                 3295                 3300             


Pro Gly  Asn Leu Phe Lys Phe  Phe Leu Pro Asp Phe  Lys Gly Phe 
    3305                 3310                 3315             


Asn Thr  Ile Asp Asn Ile Tyr  Ile Pro Ala Met Gly  Asn Phe Thr 
    3320                 3325                 3330             


Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile Thr Leu  Asn Thr Asn 
    3335                 3340                 3345             


Ala Gly  Leu Tyr Asn Gln Ser  Asp Ile Val Ala His  Phe Leu Ser 
    3350                 3355                 3360             


Ser Ser  Ser Phe Val Thr Asp  Ala Leu Gln Tyr Lys  Leu Glu Gly 
    3365                 3370                 3375             


Thr Ser  Arg Leu Met Arg Lys  Arg Gly Leu Lys Leu  Ala Thr Ala 
    3380                 3385                 3390             


Val Ser  Leu Thr Asn Lys Phe  Val Lys Gly Ser His  Asp Ser Thr 
    3395                 3400                 3405             


Ile Ser  Leu Thr Lys Lys Asn  Met Glu Ala Ser Val  Arg Thr Thr 
    3410                 3415                 3420             


Ala Asn  Leu His Ala Pro Ile  Phe Ser Met Asn Phe  Lys Gln Glu 
    3425                 3430                 3435             


Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr Val Ser  Ser Ser Ile 
    3440                 3445                 3450             


Glu Leu  Asn Tyr Asp Phe Asn  Ser Ser Lys Leu His  Ser Thr Ala 
    3455                 3460                 3465             


Thr Gly  Gly Ile Asp His Lys  Phe Ser Leu Glu Ser  Leu Thr Ser 
    3470                 3475                 3480             


Tyr Phe  Ser Ile Glu Ser Phe  Thr Lys Gly Asn Ile  Lys Ser Ser 
    3485                 3490                 3495             


Phe Leu  Ser Gln Glu Tyr Ser  Gly Ser Val Ala Asn  Glu Ala Asn 
    3500                 3505                 3510             


Val Tyr  Leu Asn Ser Lys Gly  Thr Arg Ser Ser Val  Arg Leu Gln 
    3515                 3520                 3525             


Gly Ala  Ser Lys Val Asp Gly  Ile Trp Asn Val Glu  Val Gly Glu 
    3530                 3535                 3540             


Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg Ile Tyr  Thr Thr Trp 
    3545                 3550                 3555             


Glu His  Asn Met Lys Asn His  Leu Gln Val Tyr Ser  Tyr Phe Phe 
    3560                 3565                 3570             


Thr Lys  Gly Lys Gln Thr Cys  Arg Ala Thr Leu Glu  Leu Ser Pro 
    3575                 3580                 3585             


Trp Thr  Met Ser Thr Leu Leu  Gln Val His Val Ser  Gln Leu Ser 
    3590                 3595                 3600             


Ser Leu  Leu Asp Leu His His  Phe Asp Gln Glu Val  Ile Leu Lys 
    3605                 3610                 3615             


Ala Asn  Thr Lys Asn Gln Lys  Ile Ser Trp Lys Gly  Gly Val Gln 
    3620                 3625                 3630             


Val Glu  Ser Arg Val Leu Gln  His Asn Ala Gln Phe  Ser Asn Asp 
    3635                 3640                 3645             


Gln Glu  Glu Ile Arg Leu Asp  Leu Ala Gly Ser Leu  Asp Gly Gln 
    3650                 3655                 3660             


Leu Trp  Asp Leu Glu Ala Ile  Phe Leu Pro Val Tyr  Gly Lys Ser 
    3665                 3670                 3675             


Leu Gln  Glu Leu Leu Gln Met  Asp Gly Lys Arg Gln  Tyr Leu Gln 
    3680                 3685                 3690             


Ala Ser  Thr Ser Leu Leu Tyr  Thr Lys Asn Pro Asn  Gly Tyr Leu 
    3695                 3700                 3705             


Leu Ser  Leu Pro Val Gln Glu  Leu Ala Asp Arg Phe  Ile Ile Pro 
    3710                 3715                 3720             


Gly Ile  Lys Leu Asn Asp Phe  Ser Gly Val Lys Ile  Tyr Lys Lys 
    3725                 3730                 3735             


Leu Ser  Thr Ser Pro Phe Ala  Leu Asn Leu Thr Met  Leu Pro Lys 
    3740                 3745                 3750             


Val Lys  Phe Pro Gly Ile Asp  Leu Leu Thr Gln Tyr  Ser Thr Pro 
    3755                 3760                 3765             


Glu Gly  Ser Ser Val Pro Ile  Phe Glu Ala Thr Ile  Pro Glu Ile 
    3770                 3775                 3780             


His Leu  Thr Val Ser Gln Phe  Thr Leu Pro Lys Ser  Leu Pro Val 
    3785                 3790                 3795             


Gly Asn  Thr Val Phe Asp Leu  Asn Lys Leu Ala Asn  Met Ile Ala 
    3800                 3805                 3810             


Asp Val  Asp Leu Pro Ser Val  Thr Leu Pro Glu Gln  Thr Ile Val 
    3815                 3820                 3825             


Ile Pro  Pro Leu Glu Phe Ser  Val Pro Ala Gly Ile  Phe Ile Pro 
    3830                 3835                 3840             


Phe Phe  Gly Glu Leu Thr Ala  Arg Ala Gly Met Ala  Ser Pro Leu 
    3845                 3850                 3855             


Tyr Asn  Val Thr Trp Ser Ala  Gly Trp Lys Thr Lys  Ala Asp His 
    3860                 3865                 3870             


Val Glu  Thr Phe Leu Asp Ser  Met Cys Thr Ser Thr  Leu Gln Phe 
    3875                 3880                 3885             


Leu Glu  Tyr Ala Leu Lys Val  Val Glu Thr His Lys  Ile Glu Glu 
    3890                 3895                 3900             


Asp Leu  Leu Thr Tyr Asn Ile  Lys Gly Thr Leu Gln  His Cys Asp 
    3905                 3910                 3915             


Phe Asn  Val Glu Tyr Asn Glu  Asp Gly Leu Phe Lys  Gly Leu Trp 
    3920                 3925                 3930             


Asp Trp  Gln Gly Glu Ala His  Leu Asp Ile Thr Ser  Pro Ala Leu 
    3935                 3940                 3945             


Thr Asp  Phe His Leu Tyr Tyr  Lys Glu Asp Lys Thr  Ser Leu Ser 
    3950                 3955                 3960             


Ala Ser  Ala Ala Ser Ser Thr  Ile Gly Thr Val Gly  Leu Asp Ser 
    3965                 3970                 3975             


Ser Thr  Asp Asp Gln Ser Val  Glu Leu Asn Val Tyr  Phe His Pro 
    3980                 3985                 3990             


Gln Ser  Pro Pro Glu Lys Lys  Leu Ser Ile Phe Lys  Thr Glu Trp 
    3995                 4000                 4005             


Arg Tyr  Lys Glu Ser Asp Gly  Glu Arg Tyr Ile Lys  Ile Asn Trp 
    4010                 4015                 4020             


Glu Glu  Glu Ala Ala Ser Arg  Leu Leu Gly Ser Leu  Lys Ser Asn 
    4025                 4030                 4035             


Val Pro  Lys Ala Ser Lys Ala  Ile Tyr Asp Tyr Ala  Asn Lys Tyr 
    4040                 4045                 4050             


His Leu  Glu Tyr Val Ser Ser  Glu Leu Arg Lys Ser  Leu Gln Val 
    4055                 4060                 4065             


Asn Ala  Glu His Ala Arg Arg  Met Val Asp Glu Met  Asn Met Ser 
    4070                 4075                 4080             


Phe Gln  Arg Val Ala Arg Asp  Thr Tyr Gln Asn Leu  Tyr Glu Glu 
    4085                 4090                 4095             


Met Leu  Ala Gln Lys Ser Leu  Ser Ile Pro Glu Asn  Leu Lys Lys 
    4100                 4105                 4110             


Arg Val  Leu Asp Ser Ile Val  His Val Thr Gln Lys  Tyr His Met 
    4115                 4120                 4125             


Ala Val  Met Trp Leu Met Asp  Ser Phe Ile His Phe  Leu Lys Phe 
    4130                 4135                 4140             


Asn Arg  Val Gln Phe Pro Gly  Tyr Ala Gly Thr Tyr  Thr Val Asp 
    4145                 4150                 4155             


Glu Leu  Tyr Thr Ile Val Met  Lys Glu Thr Lys Lys  Ser Leu Ser 
    4160                 4165                 4170             


Gln Leu  Phe Asn Gly Leu Gly  Asn Leu Leu Ser Tyr  Val Gln Asn 
    4175                 4180                 4185             


Gln Val  Glu Lys Ser Arg Leu  Ile Asn Asp Ile Thr  Phe Lys Cys 
    4190                 4195                 4200             


Pro Phe  Phe Ser Lys Pro Cys  Lys Leu Lys Asp Leu  Ile Leu Ile 
    4205                 4210                 4215             


Phe Arg  Glu Glu Leu Asn Ile  Leu Ser Asn Ile Gly  Gln Gln Asp 
    4220                 4225                 4230             


Ile Lys  Phe Thr Thr Ile Leu  Ser Ser Leu Gln Gly  Phe Leu Glu 
    4235                 4240                 4245             


Arg Val  Leu Asp Ile Ile Glu  Glu Gln Ile Lys Cys  Leu Lys Asp 
    4250                 4255                 4260             


Asn Glu  Ser Thr Cys Val Ala  Asp His Ile Asn Met  Val Phe Lys 
    4265                 4270                 4275             


Ile Gln  Val Pro Tyr Ala Phe  Lys Ser Leu Arg Glu  Asp Ile Tyr 
    4280                 4285                 4290             


Phe Val  Leu Gly Glu Phe Asn  Asp Phe Leu Gln Ser  Ile Leu Gln 
    4295                 4300                 4305             


Glu Gly  Ser Tyr Lys Leu Gln  Gln Val His Gln Tyr  Met Lys Ala 
    4310                 4315                 4320             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Met Val Gly  Trp Thr Val 
    4325                 4330                 4335             


Lys Tyr  Tyr Glu Ile Glu Glu  Asn Met Val Glu Leu  Ile Lys Thr 
    4340                 4345                 4350             


Leu Leu  Val Ser Phe Arg Asp  Val Tyr Ser Glu Tyr  Ser Val Thr 
    4355                 4360                 4365             


Ala Ala  Asp Phe Ala Ser Lys  Met Ser Thr Gln Val  Glu Gln Phe 
    4370                 4375                 4380             


Val Ser  Arg Asp Ile Arg Glu  Tyr Leu Ser Met Leu  Thr Asp Ile 
    4385                 4390                 4395             


Asn Gly  Lys Trp Met Glu Lys  Ile Ala Glu Leu Ser  Ile Val Ala 
    4400                 4405                 4410             


Lys Glu  Thr Met Lys Ser Trp  Val Thr Ala Val Ala  Lys Ile Met 
    4415                 4420                 4425             


Ser Asp  Tyr Pro Gln Gln Phe  His Ser Asn Leu Gln  Asp Phe Ser 
    4430                 4435                 4440             


Asp Gln  Leu Ser Ser Tyr Tyr  Glu Lys Phe Val Gly  Glu Ser Thr 
    4445                 4450                 4455             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Val  Phe Leu Arg 
    4460                 4465                 4470             


Tyr Ile  Thr Glu Leu Leu Arg  Lys Leu Gln Val Ala  Thr Ala Asn 
    4475                 4480                 4485             


Asn Val  Ser Pro Tyr Ile Lys  Leu Ala Gln Gly Glu  Leu Met Ile 
    4490                 4495                 4500             


Thr Phe  
    4505 


<210>  29
<211>  13931
<212>  DNA
<213>  Mus musculus

<400>  29
tacctgcctg agctccgcct ccgaagaccc tgtagagcaa gcagcagggg ctaggcccgt       60

ggccaggcca cagccaggaa gccaccccac catccatccg ccatgggccc acgaaagcct      120

gccctgcgga cgccgttact gctgctgttc ctgctactgt tcttggacac cagcgtctgg      180

gctcaagatg aagtcctgga aaacttaagc ttcagctgtc caaaagatgc aactcgattc      240

aagcacctcc gaaagtacgt gtacaactat gaagctgaaa gttccagcgg tgtccagggc      300

acagctgact ccagaagcgc caccaagatc aactgtaagg tagagctgga ggtcccccaa      360

atctgtggtt tcatcatgag gaccaaccag tgtaccctta aagaggtgta tggcttcaac      420

cctgagggca aggccttgat gaagaaaacc aagaactctg aagagtttgc agctgccatg      480

tccaggtacg aactcaagct ggccattcct gaagggaaac aaattgttct ttaccctgac      540

aaggatgaac ctaaatatat cctgaacatc aagaggggca tcatctctgc tcttctggtt      600

cccccagaga cagaagagga ccaacaagag ttgttcctgg ataccgtgta tggaaactgc      660

tcaactcagg ttaccgtgaa ttcaagaaag ggaaccgtac caacagaaat gtccacagag      720

agaaacctgc agcaatgtga cggcttccag cccatcagta caagtgtcag ccctctcgct      780

ctcatcaaag gcctggtcca ccccttgtca actcttatca gcagcagcca aacttgccag      840

tacaccctgg atcctaagag gaagcatgtg tctgaagctg tctgtgatga gcagcatctt      900

ttcctgcctt tctcctacaa gaataagtat gggatcatga cacgtgttac acagaaactg      960

agtcttgaag acacacctaa gatcaacagt cgcttcttca gtgaaggtac caaccggatg     1020

ggtctggcct ttgagagcac caagtccacg tcatccccaa agcaggctga tgctgttttg     1080

aagacccttc aagaactgaa aaaattgtcc atctcagagc agaatgctca gagagcaaat     1140

ctcttcaata aactggttac tgagctgaga ggcctcactg gtgaagcaat cacatccctc     1200

ttgccacagc tgattgaagt gtccagcccc atcactttac aagccttggt tcagtgtgga     1260

cagccacagt gctatactca catcctccag tggctgaaaa ctgagaaggc tcaccccctc     1320

ctggttgaca ttgtcaccta cctgatggct ctgatcccaa atccctcaac acagaggctg     1380

caggaaatct ttaatactgc caaggagcag cagagccgag ccactctgta tgcactgagc     1440

cacgcagtta acagctattt tgatgtggac cattcaagga gcccagttct gcaggatatc     1500

gctggttacc tgttgaaaca gatcgacaat gaatgcacgg gcaatgaaga ccacaccttc     1560

ttgattctga gggtcattgg aaatatggga agaaccatgg aacaagtaat gccagccctc     1620

aagtcctcag tcctgagctg tgtacgaagt acaaaaccat ctctgctgat tcagaaagct     1680

gctctccagg ccctgaggaa gatggaactg gaagatgagg tccggacgat cctttttgat     1740

acatttgtaa atggtgtcgc tcccgtggag aagagactgg ctgcctatct cttgctgatg     1800

aagaaccctt cctcatcaga tattaacaaa attgcccaac ttctccaatg ggaacagagt     1860

gagcaggtga agaacttcgt ggcatctcac attgccaaca tcttgaactc ggaagaactg     1920

tatgtccaag atctgaaagt tttgatcaaa aatgctctgg agaattctca atttccaacg     1980

atcatggact tcagaaaatt ttcccgaaac tatcagattt ccaaatctgc ttctctccca     2040

atgttcgacc cagtctcagt caaaatagaa gggaatctta tatttgatcc aagcagttat     2100

cttcccagag aaagcttgct gaaaacaacc ctcacagtct ttggacttgc ttcacttgat     2160

ctctttgaga ttggtttaga aggaaaaggg tttgagccaa cactagaagc tctttttggt     2220

aagcaaggat tcttcccaga cagtgtcaac aaggctttgt attgggtcaa tggccgagtt     2280

ccagatggtg tctccaaggt cttggtggac cactttggct atactacaga tggcaagcat     2340

gaacaggaca tggtgaatgg aatcatgccc attgtggaca agttgatcaa agatctgaaa     2400

tctaaagaaa ttcctgaagc cagggcctat ctccgcatcc taggaaaaga gctaagcttt     2460

gtcagactcc aagacctcca agtcctgggg aagctgttgc tgagtggtgc acaaactttg     2520

cagggaatcc cccagatggt tgtacaggcc atcagagaag ggtcaaagaa tgacttgttt     2580

ctccactaca tcttcatgga caatgccttt gagctcccca ctggagcagg gttacagctg     2640

caagtgtcct cgtctggagt cttcaccccc gggatcaagg ctggtgtaag actggaatta     2700

gccaacatac aggcagagct agtggcaaag ccctctgtgt ccttggagtt tgtgacaaat     2760

atgggcatca tcatcccaga cttcgctaag agcagtgtcc agatgaacac caacttcttc     2820

cacgagtcag gcctggaggc gcgagtggcc ctgaaggctg ggcagctgaa ggtcatcatt     2880

ccttctccaa agaggccagt caagctgttc agtggcagca acacactgca tctggtctct     2940

accaccaaaa cagaagtgat cccacctctg gttgagaaca ggcagtcctg gtcaacttgc     3000

aagcctctct tcactggaat gaactactgt accacaggag cttactccaa cgccagctcc     3060

acggagtctg cctcttacta cccactgaca ggggacacaa ggtatgagct ggagctgagg     3120

cccacgggag aagtggagca gtattctgcc actgcaacct atgaactcct aaaagaggac     3180

aagtctttgg ttgacacatt gaagttccta gttcaagcag aaggagtgca gcagtctgaa     3240

gctactgtac tgttcaaata taatcggaga agcaggacct tatctagtga agtcctaatt     3300

ccagggtttg atgtcaactt cgggacaata ctaagagtta atgatgaatc tgctaaggac     3360

aaaaacactt acaaactcat cctggacatt cagaacaaga aaatcactga ggtctctctc     3420

gtgggccact tgagttatga taaaaaggga gatggcaaga tcaaaggtgt tgtttccata     3480

ccacgtttgc aagcagaagc caggagtgag gtccacaccc actggtcctc caccaaactg     3540

ctcttccaaa tggactcatc tgctacagct tacggctcaa caatttccaa gagagtgaca     3600

tggcgttacg ataatgagat aatagaattt gattggaaca cgggaaccaa tgtggatacc     3660

aaaaaagtgg cctccaattt ccctgtggat ctttcccatt atcctagaat gttgcatgag     3720

tatgccaatg gtctcctgga tcacagagtc cctcaaacag atgtgacttt tcgggacatg     3780

ggttccaaat taattgttgc aacaaacaca tggcttcaga tggcaaccag gggtcttcct     3840

tacccccaaa ctctacagga tcacctcaat agcctctcag agttgaacct cctgaaaatg     3900

ggactgtctg acttccatat tccagacaac ctcttcctaa agactgatgg cagagtcaaa     3960

tacacaatga acaggaacaa aataaacatt gacatccctt tgcctttggg tggcaagtct     4020

tcaaaagacc tcaagatgcc agagagtgtg aggacaccag ccctcaactt caagtctgtg     4080

ggattccatc tgccatctcg agaggtccag gtccccactt ttacaatccc caagacacat     4140

cagcttcaag tgcctctctt gggtgttcta gacctttcca caaatgtcta cagcaatttg     4200

tacaactggt cagcctccta cactggtggc aacaccagca gagaccactt cagccttcag     4260

gctcagtacc gcatgaagac tgactctgtg gttgacctgt tttcctacag tgtgcaagga     4320

tctggagaaa caacatatga cagcaagaac acatttacat tgtcctgtga tggatctcta     4380

caccataaat ttctagactc aaaattcaaa gtcagccacg tagaaaaatt tggaaacagc     4440

ccagtctcaa aaggtttact aacatttgaa acatctagtg ccttgggacc acagatgtct     4500

gctactgttc acctagactc aaaaaagaaa caacatctat acgtcaaaga tatcaaggtt     4560

gatggacagt tcagagcttc ttcattttat gctcaaggca aatatggcct gtcttgtgag     4620

agagatgtta caactggcca gctgagcggc gaatccaaca tgagatttaa ctccacctac     4680

ttccagggca ccaaccagat cgtgggaatg taccaggatg gagccctgtc catcacctcc     4740

acttctgacc tgcaagatgg catattcaag aacacagctt ccttgaaata tgaaaactat     4800

gagctgactc tgaaatctga tagcagtggg cagtatgaga acttcgctgc ttccaacaag     4860

ctggatgtga ccttctctac gcaaagtgca ctgctgcgtt ctgaacacca ggccaattac     4920

aagtccctga ggcttgtcac ccttctttca ggatccctca cttcccaggg tgtagaatta     4980

aatgctgaca tcttgggcac agacaaaatt aatactggtg ctcacaaggc aacactaaag     5040

attgcacgtg atggactatc aaccagtgcg accaccaact tgaagtacag ccccctgctg     5100

ctggagaatg agttgaatgc agagcttggg ctctctgggg catccatgaa attatcaaca     5160

aacggccgct tcaaagaaca ccatgcaaaa ttcagtcttg atgggagagc tgccctcaca     5220

gaggtgtcac tggggagcat ttaccaggcc atgattctgg gtgcagacag caaaaacatc     5280

ttcaacttca aactcagccg agaagggctg aggctgtcca atgatttgat gggctcctat     5340

gctgagatga aacttgacca cacacacagt ctgaacattg caggtctctc actggacttc     5400

ttctcaaaaa tggacaatat ttacagtgga gacaagttct ataagcagaa ttttaactta     5460

cagctacagc cctattcttt cataactact ttaagcaacg acctgagata tggtgctcta     5520

gatttgacca acaatggaag gtttcggctg gagccactga agctgaatgt gggtggcaac     5580

tttaaaggaa cctatcaaaa taatgagctg aaacatatct ataccatatc ttatactgac     5640

ctggtagtag caagttacag agcagacact gtggctaagg ttcagggtgt cgaattcagc     5700

cataggctaa atgcagacat tgaaggactg acttcctctg ttgatgtcac taccagctac     5760

aattcagatc cactgcattt taacaatgtt ttccactttt ctctggcacc ttttaccttg     5820

ggcatcgaca cacatacaag tggtgatggg aaactgtcct tctggggaga acacactggg     5880

cagctatata gtaagtttct gttgaaagca gaacctctgg cacttattgt ctctcatgac     5940

tacaaaggat ccacaagcca cagtctcccg tacgagagca gcatcagcac ggctcttgaa     6000

cacacagtca gtgccttgct gacgccagct gagcagacaa gcacctggaa attcaagacc     6060

aaactgaatg acaaagtata cagccaggac tttgaagcct acaacactaa agacaaaatc     6120

ggtgttgagc ttagtggacg ggctgacctc tctgggctgt attctccaat taaactaccg     6180

tttttctaca gtgagcctgt caatgtcctt aatggcttag aggtaaatga tgctgttgac     6240

aagccccaag aattcacaat tattgctgtg gtgaagtacg ataagaacca ggatgttcac     6300

accatcaacc tcccattctt caaaagcctg ccagactatt tggagagaaa tcgaagagga     6360

atgataagtc tactggaagc catgcgaggg gaattgcaac gcctcagtgt tgatcagttt     6420

gtgaggaaat acagagcggc cctgagcaga cttcctcagc agattcatca ttatctgaat     6480

gcatctgact gggagagaca agtagctggt gccaaggaaa aaataacttc tttcatggaa     6540

aattatagaa ttacagataa tgatgtacta attgccatag atagtgccaa aatcaacttc     6600

aatgaaaaac tctctcaact tgagacatac gcgatacaat ttgatcagta tattaaagat     6660

aattatgatc cacatgactt aaaaagaact attgctgaga ttattgatcg aatcattgaa     6720

aagttaaaaa ttcttgatga acagtatcat atccgtgtaa atctagcaaa atcaatccat     6780

aatctctatt tatttgttga aaacgttgat cttaaccaag tcagtagtag taacacctct     6840

tggatccaaa atgtggattc caattatcaa gtcagaatcc aaattcaaga aaaactacag     6900

cagctcagga cacaaattca gaatatagac attcagcagc ttgctgcaga ggtaaaacga     6960

cagatggacg ctattgatgt cacaatgcat ttagatcaat tgagaactgc aattctattc     7020

caaagaataa gtgacattat tgaccgtgtc aaatactttg ttatgaatct tattgaagat     7080

tttaaagtaa ctgagaaaat caatactttt agagttatag tccgtgagct aattgagaaa     7140

tatgaagtag accaacacat ccaggtttta atggataaat cagtagagtt ggcccacaga     7200

tatagcctga gcgagcctct tcagaaactc agtaatgtgc tacagcgaat tgagataaaa     7260

gattactatg agaaattggt tgggtttatt gatgatactg ttgagtggct taaagcattg     7320

tctttcaaaa ataccattga agaactaaat agattgactg acatgttggt gaagaagttg     7380

aaagcatttg attatcacca gtttgtagac aaaaccaaca gcaaaatccg tgagatgact     7440

cagagaatca atgctgaaat ccaagctctc aaacttccac aaaaaatgga agcattaaaa     7500

ctgttggtag aagacttcaa aaccacagtc tccaattccc tggaaagact caaggacacc     7560

aaagtaactg tggtcattga ttggctgcag gatattttga ctcaaatgaa agaccatttc     7620

caagatactc tggaagatgt aagagaccga atttatcaaa tggacattca gagggaactg     7680

gagcacttct tgtctctggt aaaccaagtt tacagtacac tggtcaccta tatgtctgac     7740

tggtggactc tgactgctaa aaacataaca gactttgcag agcaatattc catccaaaac     7800

tgggctgaga gtataaaagt actggtggaa caaggattca tagttcctga aatgcaaaca     7860

tttctgtgga ccatgcctgc ttttgaggtc agtctccgtg ctctccaaga aggtaacttt     7920

cagacccctg tctttatagt ccccttgaca gatttgagga ttccatcaat tcggataaac     7980

tttaaaatgt taaagaatat aaaaatccca ttgagatttt ccactccaga attcactctt     8040

ctcaacacct tccatgtcca ttcctttaca attgacttgc tggaaataaa agcaaagatc     8100

attagaacta tcgaccaaat tttgagcagt gagctacagt ggcctcttcc agaaatgtat     8160

ttgagagacc tggatgtagt gaacattcct cttgcaagac tgactctgcc agacttccat     8220

gtaccagaaa tcacaattcc agaattcaca atcccaaatg tcaatctcaa agatttacac     8280

gttcctgatc ttcacatacc agaattccaa cttcctcacc tctcacatac aattgaaata     8340

cctgcttttg gcaaactgca tagcatcctt aagatccaat ctcctctctt tatattagat     8400

gctaatgcca acatacagaa tgtaacaact tcagggaaca aagcagagat tgtggcttct     8460

gtcactgcta aaggagagtc ccaatttgaa gctctcaatt ttgattttca agcacaagct     8520

caattcctgg agttaaatcc tcatcctcca gtcctgaagg aatccatgaa cttctccagt     8580

aagcatgtga gaatggagca tgagggtgag atagtatttg atggaaaggc cattgagggg     8640

aaatcagaca cagtcgcaag tttacacaca gagaaaaatg aagtagagtt taataatggt     8700

atgactgtca aagtaaacaa tcagctcacc cttgacagtc acacaaagta cttccacaag     8760

ttgagtgttc ctaggctgga cttctccagt aaggcttctc ttaataatga aatcaagaca     8820

ctattagaag ctggacatgt ggcattgaca tcttcaggga cagggtcatg gaactgggcc     8880

tgtcccaact tctcggatga aggcatacat tcgtcccaaa ttagctttac tgtggatggt     8940

cccattgctt ttgttggact atccaataac ataaatggca aacacttacg ggtcatccaa     9000

aaactgactt atgaatctgg cttcctcaac tattctaagt ttgaagttga gtcaaaagtt     9060

gaatctcagc acgtgggctc cagcattcta acagccaatg gtcgggcact gctcaaggac     9120

gcaaaggcag aaatgactgg tgagcacaat gccaacttaa atggaaaagt tattggaact     9180

ttgaaaaatt ctctcttctt ttcagcacaa ccatttgaga ttactgcatc cacaaataat     9240

gaaggaaatt tgaaagtggg ttttccacta aagctgactg ggaaaataga cttcctgaat     9300

aactatgcat tgtttctgag tccccgtgcc caacaagcaa gctggcaagc gagtaccaga     9360

ttcaatcagt acaaatacaa tcaaaacttt tctgctataa acaatgaaca caacatagaa     9420

gccagtatag gaatgaatgg agatgccaac ctggatttct taaacatacc tttaacaatt     9480

cctgaaatta acttgcctta cacggagttc aaaactccct tactgaagga tttctccata     9540

tgggaagaaa caggcttgaa agaatttttg aagacaacaa agcaatcatt tgatttgagt     9600

gtaaaggctc aatataaaaa gaacagtgac aagcattcca ttgttgtccc tctgggtatg     9660

ttttatgaat ttattctcaa caatgtcaat tcgtgggaca gaaaatttga gaaagtcaga     9720

aacaatgctt tacattttct taccacctcc tataatgaag caaaaattaa ggttgataag     9780

tacaaaactg aaaattccct taatcagccc tctgggacct ttcaaaatca tggctacact     9840

atcccagttg tcaacattga agtatctcca tttgctgtag agacactggc ttccagccat     9900

gtgatcccca cagcaataag caccccaagt gtcacaatcc ctggtcctaa catcatggtg     9960

ccttcataca agttagtgct gccacccctg gagttgccag ttttccatgg tcctgggaat    10020

ctattcaagt ttttcctccc agatttcaag ggattcaaca ctattgacaa tatttatatt    10080

ccagccatgg gcaactttac ctatgacttt tcttttaaat caagtgtcat cacactgaat    10140

accaatgctg gactttataa ccaatcagat atcgttgccc atttcctttc ttcctcttca    10200

tttgtcactg acgccctgca gtacaaatta gagggaacat cacgtctgat gcgaaaaagg    10260

ggattgaaac tagccacagc tgtctctcta actaacaaat ttgtaaaggg cagtcatgac    10320

agcaccatta gtttaaccaa gaaaaacatg gaagcatcag tgagaacaac tgccaacctc    10380

catgctccca tattctcaat gaacttcaag caggaactta atggaaatac caagtcaaaa    10440

cccactgttt catcatccat tgaactaaac tatgacttca attcctcaaa gctgcactct    10500

actgcaacag gaggcattga tcacaagttc agcttagaaa gtctcacttc ctacttttcc    10560

attgagtcat tcaccaaagg aaatatcaag agttccttcc tttctcagga atattcagga    10620

agtgttgcca atgaagccaa tgtatatctg aattccaagg gtactcggtc ttcagtgagg    10680

ctacaaggag cttccaaagt tgatggtatc tggaacgttg aagtaggaga aaattttgct    10740

ggagaagcca ccctccaacg catctacacc acatgggagc acaatatgaa aaaccatttg    10800

caggtatata gctacttctt cacaaaagga aagcaaacat gcagagctac tttggagctc    10860

tccccatgga ccatgtcaac cttgctacag gttcatgtga gtcaactcag ttccctcctt    10920

gacctccatc actttgacca ggaagtgatc ctaaaagcta acactaagaa ccagaagatc    10980

agctggaaag gtggggtcca ggttgaatca cgggttcttc agcacaatgc acagttctcc    11040

aatgaccaag aagaaatacg gcttgacctt gcaggatcct tagacggaca gctgtgggac    11100

cttgaagcta tctttttacc agtatatggc aagagcttgc aggaactcct acaaatggat    11160

ggaaagcgac agtatcttca agcttcaact tctcttctat ataccaaaaa ccctaatggc    11220

tatctcctct cactccccgt gcaagaactg gctgatagat ttattatacc agggataaaa    11280

ctaaatgact tcagtggagt aaaaatctat aagaagttaa gtacttcacc atttgccctc    11340

aacctaacaa tgctccccaa agtaaaattc cctgggattg atctgttaac acagtactct    11400

acaccagagg gctcctctgt ccctattttt gaggcaacta tacctgaaat tcatttaact    11460

gtatcccagt ttacacttcc aaagagcctt ccagttggca acacagtctt tgatctgaat    11520

aagttggcca acatgattgc cgatgttgac ctgcctagtg tcaccctgcc tgagcagact    11580

attgtaatcc cacccttgga gttctctgta cctgctggga tttttattcc tttctttgga    11640

gaactgactg cacgtgctgg gatggcttct cccctgtata atgtcacttg gagcgctggt    11700

tggaaaacca aagcagatca tgttgaaacg ttcctagatt ccatgtgcac ttcaaccttg    11760

cagtttctgg agtatgcttt aaaagttgta gaaacacaca aaattgaaga agatctgtta    11820

acctataata tcaaaggaac acttcaacac tgtgacttca atgtggagta taatgaagat    11880

ggtctattta aaggactttg ggactggcag ggagaggctc acctggacat caccagccca    11940

gcactgactg actttcatct gtactacaaa gaagacaaga caagtctgtc tgcctcagca    12000

gcctcctcga ccatcggcac tgtgggtctg gattcgagca cagatgacca gagtgtggag    12060

ctgaatgtct acttccaccc acagtcccct ccagagaaga aactcagcat attcaaaact    12120

gagtggaggt acaaggagtc tgatggtgaa aggtacatca aaattaattg ggaagaagag    12180

gcagcttcca gattgctagg ctccctaaaa agcaatgtgc ccaaggcttc taaggctatt    12240

tatgattatg ccaataagta ccacctggaa tacgtttctt cagaactaag aaaaagtcta    12300

caggtcaatg ctgaacatgc cagaaggatg gttgatgaaa tgaacatgag tttccagaga    12360

gtagcccgtg atacctacca gaatctctat gaggagatgt tggctcagaa gagcctgagc    12420

atccctgaga atctcaagaa gagggtgtta gacagtatag tacatgttac tcagaagtac    12480

cacatggcag tcatgtggct gatggactca ttcattcatt ttctgaaatt caatagagtc    12540

cagttcccag ggtacgctgg aacatatact gtggacgaac tctacactat agtcatgaag    12600

gaaaccaaga agtcactgtc tcagctgttt aatgggttag gaaacctact ttcctacgtt    12660

caaaaccaag tagagaaatc aagattaatc aatgacataa catttaaatg tccttttttc    12720

tcaaaacctt gtaaactaaa agatctcata ttgattttca gggaggagtt aaacatttta    12780

tcaaacatag gccaacagga tatcaagttt acaacaatac taagtagtct tcagggcttt    12840

ttggagagag ttttagacat catagaagaa caaattaaat gcctaaagga caatgaatct    12900

acttgtgttg ctgaccatat caacatggtt ttcaaaatac aggtcccata tgcttttaaa    12960

tccctaagag aagacatata ctttgtcctc ggtgagttca atgactttct tcaatccata    13020

cttcaggagg ggtcctacaa gctacagcag gtccatcagt atatgaaggc ccttcgtgaa    13080

gagtattttg atccgagcat ggttgggtgg acagtgaaat attatgaaat agaagaaaat    13140

atggttgagc tgatcaagac ccttttagtt tcctttaggg atgtctactc tgaatatagt    13200

gtgacagctg ctgattttgc ttccaaaatg tcaactcaag ttgaacaatt tgtgtccagg    13260

gatatcagag agtatcttag catgcttact gatataaatg gaaagtggat ggaaaagatt    13320

gcagagcttt ctattgtggc aaaggaaaca atgaaaagct gggtcactgc cgtggccaaa    13380

ataatgtctg attaccccca gcagttccac tccaatctgc aggatttttc agaccaactc    13440

tctagctact atgaaaaatt tgttggtgag tccacaagat tgattgacct gtccattcaa    13500

aactaccacg tgtttctcag atacatcacc gagttactga gaaagctgca ggtggccaca    13560

gccaataatg tgagccccta tataaagctt gctcaaggag agctgatgat caccttctga    13620

ttcatctact aacaaattca aattaaacct tcacatagta ggagactttg tagactacta    13680

taaagaccat cctgagccag acctgcagtc aacagcaaga gcaagaagca cataggaact    13740

atacctgcaa ccaagctggc ataagaacca agaccttcaa agcagcctga actcaagatg    13800

acatatttta caagttagag taaagtcaag agctgagttg ttttgtccaa ctcaggatgg    13860

agggagggag ggaaggggaa ataaataaat acttccttat tgtgcagcaa aaaaaaaaaa    13920

aaaaaaaaaa a                                                         13931


