                         SEQUENCE LISTING

<110>  Transgene SA
       SILVESTRE, Nathalie
       GEIST, Michel
       RITTNER, Karola
       MARCHAND, Jean-Baptiste
       THIOUDELLET, Christine
 
<120>  Oncolytic virus for expression of immune checkpoint modulators

<130>  B368022D35114

<150>  EP14306153.9
<151>  2014-07-16

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  478
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for anti PD-1 heavy chain

<400>  1

Met Gly Leu Gly Leu Gln Trp Val Phe Phe Val Ala Leu Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Thr Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Ala Cys Asp Ser Thr Thr Ser 
145                 150                 155                 160 


Thr Thr Asp Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ser Val Leu His Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Ser Val Thr Val Pro Ser Ser Thr Trp Pro Lys Gln Pro Ile Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu 
225                 230                 235                 240 


Pro Arg Thr Asp Thr Asp Thr Cys Pro Asn Pro Pro Asp Pro Cys Pro 
                245                 250                 255     


Thr Cys Pro Thr Pro Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Ile 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser Glu Glu Glu Pro Asp Val Gln Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asn Asn Val Glu Asp Lys Thr Ala Gln Thr Glu Thr 
305                 310                 315                 320 


Arg Gln Arg Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro 
                325                 330                 335     


Ile Lys His Gln Asp Trp Met Ser Gly Lys Val Phe Lys Cys Lys Val 
            340                 345                 350         


Asn Asn Asn Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro 
        355                 360                 365             


Arg Gly Gln Val Arg Val Pro Gln Ile Tyr Thr Phe Pro Pro Pro Ile 
    370                 375                 380                 


Glu Gln Thr Val Lys Lys Asp Val Ser Val Thr Cys Leu Val Thr Gly 
385                 390                 395                 400 


Phe Leu Pro Gln Asp Ile His Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Gln Pro Glu Gln Asn Tyr Lys Asn Thr Gln Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Asn Val Pro Lys Ser Arg Trp 
        435                 440                 445             


Asp Gln Gly Asp Ser Phe Thr Cys Ser Val Ile His Glu Ala Leu His 
    450                 455                 460                 


Asn His His Met Thr Lys Thr Ile Ser Arg Ser Leu Gly Asn 
465                 470                 475             


<210>  2
<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for anti PD1 light chain

<400>  2

Met Ala Trp Thr Pro Gly Ile Phe Met Val Leu Ser Tyr Leu Thr Gly 
1               5                   10                  15      


Ser Phe Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Val Asn Val 
            20                  25                  30          


Gly Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys Tyr 
        35                  40                  45              


Phe Ala Asp Trp Phe His Gln Arg Ser Asp Gln Thr Ile Leu Gln Val 
    50                  55                  60                  


Ile Tyr Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser 
65                  70                  75                  80  


Gly Ser Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Arg Asp Val Arg 
                85                  90                  95      


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Phe Ser Gly Tyr Val Asp Ser 
            100                 105                 110         


Asp Ser Lys Leu Tyr Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu 
        115                 120                 125             


Gly Gly Pro Lys Ser Ser Pro Lys Val Thr Val Phe Pro Pro Ser Pro 
    130                 135                 140                 


Glu Glu Leu Arg Thr Asn Lys Ala Thr Leu Val Cys Leu Val Asn Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ser Ala Thr Val Thr Trp Lys Ala Asn Gly Ala Thr 
                165                 170                 175     


Ile Asn Asp Gly Val Lys Thr Thr Lys Pro Ser Lys Gln Gly Gln Asn 
            180                 185                 190         


Tyr Met Thr Ser Ser Tyr Leu Ser Leu Thr Ala Asp Gln Trp Lys Ser 
        195                 200                 205             


His Asn Arg Val Ser Cys Gln Val Thr His Glu Gly Glu Thr Val Glu 
    210                 215                 220                 


Lys Ser Leu Ser Pro Ala Glu Cys Leu 
225                 230             


