                         SEQUENCE LISTING

<110>  Universitaet zu Koeln
 
<120>  Chimeric antigen receptor and its use

<130>  4677-005 PCT-1

<150>  EP14177278.0
<151>  2014-07-16

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  756
<212>  DNA
<213>  human


<220>
<221>  CDS
<222>  (1)..(756)

<400>  1
aga atg gcc cag gtg caa ctg cag cag tca ggg gct gag ctg gct aga         48
Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg           
1               5                   10                  15                

cct ggg gct tca gtg aag atg tcc tgc aag gct tct ggc tac acc ttt         96
Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe           
            20                  25                  30                    

act acc tac aca ata cac tgg gta aga cgg agg cct gga cac gat ctg        144
Thr Thr Tyr Thr Ile His Trp Val Arg Arg Arg Pro Gly His Asp Leu           
        35                  40                  45                        

gaa tgg att gga tac att aat cct agc agt gga tgt tct gac tac aat        192
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Cys Ser Asp Tyr Asn           
    50                  55                  60                            

caa aac ttc aag ggc aag acc aca ttg act gca gac aag tcc tcc aac        240
Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn           
65                  70                  75                  80            

aca gcc tac atg caa ctg aac agc ctg aca tct gag gac tct gcg gtc        288
Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val           
                85                  90                  95                

tat tac tgt gca aga aga gcg gac tat ggt aac tac gaa tat acc tgg        336
Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp           
            100                 105                 110                   

ttt gct tac tgg ggc caa ggg acc acg gtc acc gtc tcc tca agt gga        384
Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly           
        115                 120                 125                       

ggc ggt tca ggt gga ggt ggc tct ggc ggt ggc gga tcg gtc atc gag        432
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ile Glu           
    130                 135                 140                           

ctc act cag tct cca aaa ttc atg tcc aca tca gta gga gac agg gtc        480
Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val           
145                 150                 155                 160           

aac gtc acc tac aag gcc agt cag aat gtg ggt act aat gta gcc tgg        528
Asn Val Thr Tyr Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp           
                165                 170                 175               

ttt caa caa aaa cca ggg caa tct cct aaa gtt ctg att tac tcg gca        576
Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala           
            180                 185                 190                   

tct tac cga tac agt gga gtc cct gat cgc ttc aca ggc agt gga tct        624
Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser           
        195                 200                 205                       

gga aca gat ttc act ctc acc atc agc aat gtg cag tct gaa gac ttg        672
Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu           
    210                 215                 220                           

gca gag tat ttc tgt cag caa tat cac acc tat cct ctc acg ttc gga        720
Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly           
225                 230                 235                 240           

ggg ggc acc aag ctg gaa atc aaa cgg tca gat ccc                        756
Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Pro                           
                245                 250                                   


<210>  2
<211>  252
<212>  PRT
<213>  human

<400>  2

Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
1               5                   10                  15      


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            20                  25                  30          


Thr Thr Tyr Thr Ile His Trp Val Arg Arg Arg Pro Gly His Asp Leu 
        35                  40                  45              


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Cys Ser Asp Tyr Asn 
    50                  55                  60                  


Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Asn 
65                  70                  75                  80  


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr Trp 
            100                 105                 110         


Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ile Glu 
    130                 135                 140                 


Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Asn Val Thr Tyr Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala 
            180                 185                 190         


Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
    210                 215                 220                 


Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Pro 
                245                 250         


<210>  3
<211>  734
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic peptide


<220>
<221>  CDS
<222>  (1)..(732)

<400>  3
ggt gtc cac tcc cag gtc caa ctg cag gag tca ggt cca ggt ctt gtg         48
Gly Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val           
1               5                   10                  15                

aga cct agc cag acc ctg agc ctg acc tgc acc gtg tct ggc ttc acc         96
Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr           
            20                  25                  30                    

atc agc agt ggt tat agc tgg cac tgg gtg aga cag cca cct gga cga        144
Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg           
        35                  40                  45                        

ggt ctt gag tgg att gga tac ata cag tac agt ggt atc act aac tac        192
Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr           
    50                  55                  60                            

aac ccc tct ctc aaa agt aga gtg aca atg ctg gta gac acc agc aag        240
Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys           
65                  70                  75                  80            

aac cag ttc agc ctg aga ctc agc agc gtg aca gcc gcc gac acc gcg        288
Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala           
                85                  90                  95                

gtc tat tat tgt gca aga gaa gac tat gat tac cac tgg tac ttc gat        336
Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp           
            100                 105                 110                   

gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tca gga ggt ggt gga        384
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly           
        115                 120                 125                       

tcg ggc ggt ggc ggg tcg ggt ggc ggc gga tct gac atc cag ctg acc        432
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr           
    130                 135                 140                           

cag agc cca agc agc ctg agc gcc agc gtg ggt gac aga gtg acc atc        480
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile           
145                 150                 155                 160           

acc tgt agt acc agc tcg agt gta agt tac atg cac tgg tac cag cag        528
Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln           
                165                 170                 175               

aag cca ggt aag gct cca aag ctg ctg atc tac agc aca tcc aac ctg        576
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu           
            180                 185                 190                   

gct tct ggt gtg cca agc aga ttc agc ggt agc ggt agc ggt acc gac        624
Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp           
        195                 200                 205                       

ttc acc ttc acc atc agc agc ctc cag cca gag gac atc gcc acc tac        672
Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr           
    210                 215                 220                           

tac tgc cat cag tgg agt agt tat ccc acg ttc ggc caa ggg acc aag        720
Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys           
225                 230                 235                 240           

gtg gag atc aaa gt                                                     734
Val Glu Ile Lys                                                           
                                                                          


<210>  4
<211>  244
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Gly Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
1               5                   10                  15      


Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr 
            20                  25                  30          


Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg 
        35                  40                  45              


Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr 
    50                  55                  60                  


Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  5
<211>  705
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleic acid


<220>
<221>  CDS
<222>  (1)..(705)

<400>  5
gat ccc gcc gag ccc aaa tct cct gac aaa act cac aca tgc cca ccg         48
Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro           
1               5                   10                  15                

tgc cca gca cct cca gtc gcg gga ccg tca gtc ttc ctc ttc ccc cca         96
Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro           
            20                  25                  30                    

aaa ccc aag gac acc ctc atg atc gcc cgg acc cct gag gtc aca tgc        144
Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys           
        35                  40                  45                        

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        192
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
    50                  55                  60                            

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        240
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
65                  70                  75                  80            

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        288
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
                85                  90                  95                

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        336
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
            100                 105                 110                   

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        384
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
        115                 120                 125                       

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        432
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
    130                 135                 140                           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        480
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
145                 150                 155                 160           

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        528
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
                165                 170                 175               

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        576
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
            180                 185                 190                   

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        624
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
        195                 200                 205                       

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        672
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
    210                 215                 220                           

cag aag agc ctc tcc ctg tct ccg ggt aaa aaa                            705
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys                               
225                 230                 235                               


<210>  6
<211>  235
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  6

Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
225                 230                 235 


<210>  7
<211>  204
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleic acid


<220>
<221>  CDS
<222>  (1)..(204)

<400>  7
ttt tgg gtg ctg gtg gtg gtt ggt gga gtc ctg gct tgc tat agc ttg         48
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu           
1               5                   10                  15                

cta gta aca gtg gcc ttt att att ttc tgg gtg agg agt aag agg agc         96
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser           
            20                  25                  30                    

agg ctc ctg cac agt gac tac atg aac atg act ccc cgc cgc ccc ggg        144
Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly           
        35                  40                  45                        

ccc acc cgc aag cat tac cag gcc tat gcc gcc gca cgc gac ttc gca        192
Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala           
    50                  55                  60                            

gcc tat cgc tcc                                                        204
Ala Tyr Arg Ser                                                           
65                                                                        


<210>  8
<211>  68
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  8

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  9
<211>  414
<212>  DNA
<213>  human


<220>
<221>  CDS
<222>  (1)..(414)

<400>  9
gat ccc aaa ctc tgc tac ctg ctg gat gga atc ctc ttc atc tat ggt         48
Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly           
1               5                   10                  15                

gtc att ctc act gcc ttg ttc ctg aga gtg aag ttc agc agg agc gca         96
Val Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala           
            20                  25                  30                    

gac gcc ccc gcg tac cag cag ggc cag aac cag ctc tat aac gag ctc        144
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu           
        35                  40                  45                        

aat cta gga cga aga gag gag tac gat gtt ttg gac aag aga cgt ggc        192
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly           
    50                  55                  60                            

cgg gac cct gag atg ggg gga aag ccg cag aga agg aag aac cct cag        240
Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln           
65                  70                  75                  80            

gaa ggc ctg tac aat gaa ctg cag aaa gat aag atg gcg gag gcc tac        288
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr           
                85                  90                  95                

agt gag att ggg atg aaa ggc gag cgc cgg agg ggc aag ggg cac gat        336
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp           
            100                 105                 110                   

ggc ctt tac cag ggt ctc agt aca gcc acc aag gac acc tac gac gcc        384
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala           
        115                 120                 125                       

ctt cac atg cag gcc ctg ccc cct cgc taa                                414
Leu His Met Gln Ala Leu Pro Pro Arg                                       
    130                 135                                               


<210>  10
<211>  137
<212>  PRT
<213>  human

<400>  10

Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly 
1               5                   10                  15      


Val Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala 
            20                  25                  30          


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        35                  40                  45              


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    50                  55                  60                  


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
65                  70                  75                  80  


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                85                  90                  95      


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            100                 105                 110         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        115                 120                 125             


Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135         


<210>  11
<211>  201
<212>  DNA
<213>  human


<220>
<221>  CDS
<222>  (1)..(201)

<400>  11
gat ccc aaa ctc tgc tat atc ctg gat gcc atc ctg ttt ctg tat gga         48
Asp Pro Lys Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly           
1               5                   10                  15                

att gtc ctc acc ctc ctc tac tgt cga ctg aag atc caa gtg cga aag         96
Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys           
            20                  25                  30                    

gca gct ata acc agc tat gag aaa tca gat ggt gtt tac acg ggc ctg        144
Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu           
        35                  40                  45                        

agc acc agg aac cag gag act tac gag act ctg aag cat gag aaa cca        192
Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro           
    50                  55                  60                            

cca cag tag                                                            201
Pro Gln                                                                   
65                                                                        


<210>  12
<211>  66
<212>  PRT
<213>  human

<400>  12

Asp Pro Lys Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly 
1               5                   10                  15      


Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys 
            20                  25                  30          


Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu 
        35                  40                  45              


Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro 
    50                  55                  60                  


Pro Gln 
65      


<210>  13
<211>  2943
<212>  DNA
<213>  artificial

<220>
<223>  synthetic sequence


<220>
<221>  CDS
<222>  (1)..(2943)

<400>  13
ctc tag act gcc atg gat ttt cag gtg cag att ttc agc ttc ctg cta         48
Leu     Thr Ala Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu           
1                   5                   10                  15            

atc agt gcc tca gtc ata atg tct aga atg gcc cag gtg caa ctg cag         96
Ile Ser Ala Ser Val Ile Met Ser Arg Met Ala Gln Val Gln Leu Gln           
                20                  25                  30                

cag tca ggg gct gag ctg gct aga cct ggg gct tca gtg aag atg tcc        144
Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser           
            35                  40                  45                    

tgc aag gct tct ggc tac acc ttt act acc tac aca ata cac tgg gta        192
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val           
        50                  55                  60                        

aga cgg agg cct gga cac gat ctg gaa tgg att gga tac att aat cct        240
Arg Arg Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro           
    65                  70                  75                            

agc agt gga tgt tct gac tac aat caa aac ttc aag ggc aag acc aca        288
Ser Ser Gly Cys Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr           
80                  85                  90                  95            

ttg act gca gac aag tcc tcc aac aca gcc tac atg caa ctg aac agc        336
Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser           
                100                 105                 110               

ctg aca tct gag gac tct gcg gtc tat tac tgt gca aga aga gcg gac        384
Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp           
            115                 120                 125                   

tat ggt aac tac gaa tat acc tgg ttt gct tac tgg ggc caa ggg acc        432
Tyr Gly Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr           
        130                 135                 140                       

acg gtc acc gtc tcc tca agt gga ggc ggt tca ggt gga ggt ggc tct        480
Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser           
    145                 150                 155                           

ggc ggt ggc gga tcg gtc atc gag ctc act cag tct cca aaa ttc atg        528
Gly Gly Gly Gly Ser Val Ile Glu Leu Thr Gln Ser Pro Lys Phe Met           
160                 165                 170                 175           

tcc aca tca gta gga gac agg gtc aac gtc acc tac aag gcc agt cag        576
Ser Thr Ser Val Gly Asp Arg Val Asn Val Thr Tyr Lys Ala Ser Gln           
                180                 185                 190               

aat gtg ggt act aat gta gcc tgg ttt caa caa aaa cca ggg caa tct        624
Asn Val Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser           
            195                 200                 205                   

cct aaa gtt ctg att tac tcg gca tct tac cga tac agt gga gtc cct        672
Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro           
        210                 215                 220                       

gat cgc ttc aca ggc agt gga tct gga aca gat ttc act ctc acc atc        720
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile           
    225                 230                 235                           

agc aat gtg cag tct gaa gac ttg gca gag tat ttc tgt cag caa tat        768
Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr           
240                 245                 250                 255           

cac acc tat cct ctc acg ttc gga ggg ggc acc aag ctg gaa atc aaa        816
His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
                260                 265                 270               

cgg tca gat ccc gga ggc ggg ggt tct ggt gga ggc gga agc ggt ggc        864
Arg Ser Asp Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
            275                 280                 285                   

ggg ggt tca gga ggc ggg ggt tcc ggt ggt ggc ggc agt ggt ggt ggc        912
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly           
        290                 295                 300                       

ggc agt ggt ggt ggc ggc agt ggt ggt ggc ggc agt ggt gtc cac tcc        960
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser           
    305                 310                 315                           

cag gtc caa ctg cag gag tca ggt cca ggt ctt gtg aga cct agc cag       1008
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln           
320                 325                 330                 335           

acc ctg agc ctg acc tgc acc gtg tct ggc ttc acc atc agc agt ggt       1056
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly           
                340                 345                 350               

tat agc tgg cac tgg gtg aga cag cca cct gga cga ggt ctt gag tgg       1104
Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp           
            355                 360                 365                   

att gga tac ata cag tac agt ggt atc act aac tac aac ccc tct ctc       1152
Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu           
        370                 375                 380                       

aaa agt aga gtg aca atg ctg gta gac acc agc aag aac cag ttc agc       1200
Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser           
    385                 390                 395                           

ctg aga ctc agc agc gtg aca gcc gcc gac acc gcg gtc tat tat tgt       1248
Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
400                 405                 410                 415           

gca aga gaa gac tat gat tac cac tgg tac ttc gat gtc tgg ggc caa       1296
Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln           
                420                 425                 430               

ggg acc acg gtc acc gtc tcc tca gga ggt ggt gga tcg ggc ggt ggc       1344
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly           
            435                 440                 445                   

ggg tcg ggt ggc ggc gga tct gac atc cag ctg acc cag agc cca agc       1392
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser           
        450                 455                 460                       

agc ctg agc gcc agc gtg ggt gac aga gtg acc atc acc tgt agt acc       1440
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Thr           
    465                 470                 475                           

agc tcg agt gta agt tac atg cac tgg tac cag cag aag cca ggt aag       1488
Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys           
480                 485                 490                 495           

gct cca aag ctg ctg atc tac agc aca tcc aac ctg gct tct ggt gtg       1536
Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val           
                500                 505                 510               

cca agc aga ttc agc ggt agc ggt agc ggt acc gac ttc acc ttc acc       1584
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr           
            515                 520                 525                   

atc agc agc ctc cag cca gag gac atc gcc acc tac tac tgc cat cag       1632
Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln           
        530                 535                 540                       

tgg agt agt tat ccc acg ttc ggc caa ggg acc aag gtg gag atc aaa       1680
Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
    545                 550                 555                           

gtg gat ccc gcc gag ccc aaa tct cct gac aaa act cac aca tgc cca       1728
Val Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro           
560                 565                 570                 575           

ccg tgc cca gca cct cca gtc gcg gga ccg tca gtc ttc ctc ttc ccc       1776
Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro           
                580                 585                 590               

cca aaa ccc aag gac acc ctc atg atc gcc cgg acc cct gag gtc aca       1824
Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr           
            595                 600                 605                   

tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac       1872
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn           
        610                 615                 620                       

tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg       1920
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg           
    625                 630                 635                           

gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc       1968
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val           
640                 645                 650                 655           

ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc       2016
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser           
                660                 665                 670               

aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa       2064
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys           
            675                 680                 685                   

ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat       2112
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp           
        690                 695                 700                       

gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc       2160
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe           
    705                 710                 715                           

tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag       2208
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
720                 725                 730                 735           

aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc       2256
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
                740                 745                 750               

ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg       2304
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
            755                 760                 765                   

aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac       2352
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
        770                 775                 780                       

acg cag aag agc ctc tcc ctg tct ccg ggt aaa aaa gat ccc aaa ttt       2400
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe           
    785                 790                 795                           

tgg gtg ctg gtg gtg gtt ggt gga gtc ctg gct tgc tat agc ttg cta       2448
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu           
800                 805                 810                 815           

gta aca gtg gcc ttt att att ttc tgg gtg agg agt aag agg agc agg       2496
Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg           
                820                 825                 830               

ctc ctg cac agt gac tac atg aac atg act ccc cgc cgc ccc ggg ccc       2544
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro           
            835                 840                 845                   

acc cgc aag cat tac cag gcc tat gcc gcc gca cgc gac ttc gca gcc       2592
Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala Ala           
        850                 855                 860                       

tat cgc tcc ctg aga gtg aag ttc agc agg agc gca gac gcc ccc gcg       2640
Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala           
    865                 870                 875                           

tac cag cag ggc cag aac cag ctc tat aac gag ctc aat cta gga cga       2688
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg           
880                 885                 890                 895           

aga gag gag tac gat gtt ttg gac aag aga cgt ggc cgg gac cct gag       2736
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu           
                900                 905                 910               

atg ggg gga aag ccg aga agg aag aac cct cag gaa ggc ctg tac aat       2784
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn           
            915                 920                 925                   

gaa ctg cag aaa gat aag atg gcg gag gcc tac agt gag att ggg atg       2832
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met           
        930                 935                 940                       

aaa ggc gag cgc cgg agg ggc aag ggg cac gat ggc ctt tac cag ggt       2880
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly           
    945                 950                 955                           

ctc agt aca gcc acc aag gac acc tac gac gcc ctt cac atg cag gcc       2928
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala           
960                 965                 970                 975           

ctg ccc cct cgc taa                                                   2943
Leu Pro Pro Arg                                                           
                                                                          


<210>  14
<211>  978
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  14

Thr Ala Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser 
1               5                   10                  15      


Ala Ser Val Ile Met Ser Arg Met Ala Gln Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Arg 
    50                  55                  60                  


Arg Pro Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser 
65                  70                  75                  80  


Gly Cys Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr 
                85                  90                  95      


Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly 
        115                 120                 125             


Asn Tyr Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Val Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr 
                165                 170                 175     


Ser Val Gly Asp Arg Val Asn Val Thr Tyr Lys Ala Ser Gln Asn Val 
            180                 185                 190         


Gly Thr Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys 
        195                 200                 205             


Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
225                 230                 235                 240 


Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr 
                245                 250                 255     


Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ser 
            260                 265                 270         


Asp Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Gln Val 
305                 310                 315                 320 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu 
                325                 330                 335     


Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly Tyr Ser 
            340                 345                 350         


Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly 
        355                 360                 365             


Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
    370                 375                 380                 


Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg 
385                 390                 395                 400 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                405                 410                 415     


Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            420                 425                 430         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    450                 455                 460                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser 
465                 470                 475                 480 


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                485                 490                 495     


Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser 
            500                 505                 510         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
        515                 520                 525             


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser 
    530                 535                 540                 


Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Val Asp 
545                 550                 555                 560 


Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
                565                 570                 575     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            580                 585                 590         


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        595                 600                 605             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    610                 615                 620                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
625                 630                 635                 640 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                645                 650                 655     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            660                 665                 670         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        675                 680                 685             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    690                 695                 700                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
705                 710                 715                 720 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                725                 730                 735     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            740                 745                 750         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        755                 760                 765             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    770                 775                 780                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe Trp Val 
785                 790                 795                 800 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                805                 810                 815     


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            820                 825                 830         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        835                 840                 845             


Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala Ala Tyr Arg 
    850                 855                 860                 


Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
865                 870                 875                 880 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                885                 890                 895     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            900                 905                 910         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        915                 920                 925             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    930                 935                 940                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
945                 950                 955                 960 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                965                 970                 975     


Pro Arg 
        


<210>  15
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (8)..(20)
<223>  SVFLFPPKPKDTL

<400>  15

Pro Glu Leu Leu Gly Gly Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Met Ile Ser Arg Thr 
            20                  25  


<210>  16
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide


<220>
<221>  misc_feature
<222>  (7)..(19)
<223>  SVFLFPPKPKDTL

<400>  16

Pro Pro Val Ala Gly Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Met Ile Ala Arg Thr 
            20                  


<210>  17
<211>  2901
<212>  DNA
<213>  artificial

<220>
<223>  synthetic molecule


<220>
<221>  CDS
<222>  (1)..(2901)

<400>  17
atg gat ttt cag gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata atg tct aga cag gtg aag ctg cag cag tct ggg act gtg ctg         96
Val Ile Met Ser Arg Gln Val Lys Leu Gln Gln Ser Gly Thr Val Leu           
            20                  25                  30                    

gca agg cct ggg gct tcc gtg aag atg tcc tgc aag gct tct ggc tac        144
Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr           
        35                  40                  45                        

agg ttt acc aac tac tgg atg cac tgg gta aaa cag agg cct gga cag        192
Arg Phe Thr Asn Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln           
    50                  55                  60                            

ggt cta gaa tgg att ggt gtt att tat cct gga aat agt gat act agc        240
Gly Leu Glu Trp Ile Gly Val Ile Tyr Pro Gly Asn Ser Asp Thr Ser           
65                  70                  75                  80            

tac aac cag aag ttc aag ggc aag gcc aaa ctg act gca gtc aca tcc        288
Tyr Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser           
                85                  90                  95                

gcc agc act gcc tac atg gag ctc agc agc ctg aca aat gag gac tct        336
Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser           
            100                 105                 110                   

gcg gtc tat tac tgt aca aga gag gga gaa ggc tct gac tac tgg ggc        384
Ala Val Tyr Tyr Cys Thr Arg Glu Gly Glu Gly Ser Asp Tyr Trp Gly           
        115                 120                 125                       

caa ggg acc acg gtc acc gtc tcc tca ggt gga ggc ggt tca ggc gga        432
Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly           
    130                 135                 140                           

ggt ggc tct ggc ggt ggc gga tcg caa att gtt ctc acc cag tct cca        480
Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro           
145                 150                 155                 160           

gca acc atg gct gca tct ccc ggg gag aag atc act atc acc tgc agt        528
Ala Thr Met Ala Ala Ser Pro Gly Glu Lys Ile Thr Ile Thr Cys Ser           
                165                 170                 175               

gcc agc tca agt ata agt tcc aat tac ttg cat tgg tat cag cag aag        576
Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys           
            180                 185                 190                   

cca gga ttc tcc cct aaa ctc ttg att tat agg act tcc aat ctg gct        624
Pro Gly Phe Ser Pro Lys Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala           
        195                 200                 205                       

tct gga gtc cca gct cgc ttc agt ggc agt ggg tct ggg acc tct tac        672
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr           
    210                 215                 220                           

tct ctc aca att ggc acc atg gag gct gaa gat gtt gcc act tac tac        720
Ser Leu Thr Ile Gly Thr Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr           
225                 230                 235                 240           

tgc cag cag ggt agt agt ata ccg tac acg ttc gga ggg ggg acc aag        768
Cys Gln Gln Gly Ser Ser Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys           
                245                 250                 255               

ctg gag ctg gcg gcc gca gga ggc ggg ggt tct ggt gga ggc gga agc        816
Leu Glu Leu Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser           
            260                 265                 270                   

ggt ggc ggg ggt tca gga ggc ggg ggt tcc ggt ggt ggc ggc agt ggt        864
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
        275                 280                 285                       

ggt ggc ggc agt ggt ggt ggc ggc agt ggt ggt ggc ggc agt ggt gtc        912
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val           
    290                 295                 300                           

cac tcc cag gtc caa ctg cag gag tca ggt cca ggt ctt gtg aga cct        960
His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro           
305                 310                 315                 320           

agc cag acc ctg agc ctg acc tgc acc gtg tct ggc ttc acc atc agc       1008
Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser           
                325                 330                 335               

agt ggt tat agc tgg cac tgg gtg aga cag cca cct gga cga ggt ctt       1056
Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu           
            340                 345                 350                   

gag tgg att gga tac ata cag tac agt ggt atc act aac tac aac ccc       1104
Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro           
        355                 360                 365                       

tct ctc aaa agt aga gtg aca atg ctg gta gac acc agc aag aac cag       1152
Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln           
    370                 375                 380                           

ttc agc ctg aga ctc agc agc gtg aca gcc gcc gac acc gcg gtc tat       1200
Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr           
385                 390                 395                 400           

tat tgt gca aga gaa gac tat gat tac cac tgg tac ttc gat gtc tgg       1248
Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp           
                405                 410                 415               

ggc caa ggg acc acg gtc acc gtc tcc tca gga ggt ggt gga tcg ggc       1296
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly           
            420                 425                 430                   

ggt ggc ggg tcg ggt ggc ggc gga tct gac atc cag ctg acc cag agc       1344
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser           
        435                 440                 445                       

cca agc agc ctg agc gcc agc gtg ggt gac aga gtg acc atc acc tgt       1392
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys           
    450                 455                 460                           

agt acc agc tcg agt gta agt tac atg cac tgg tac cag cag aag cca       1440
Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro           
465                 470                 475                 480           

ggt aag gct cca aag ctg ctg atc tac agc aca tcc aac ctg gct tct       1488
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser           
                485                 490                 495               

ggt gtg cca agc aga ttc agc ggt agc ggt agc ggt acc gac ttc acc       1536
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr           
            500                 505                 510                   

ttc acc atc agc agc ctc cag cca gag gac atc gcc acc tac tac tgc       1584
Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys           
        515                 520                 525                       

cat cag tgg agt agt tat ccc acg ttc ggc caa ggg acc aag gtg gag       1632
His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu           
    530                 535                 540                           

atc aaa gtg gat ccc gcc gag ccc aaa tct cct gac aaa act cac aca       1680
Ile Lys Val Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr           
545                 550                 555                 560           

tgc cca ccg tgc cca gca cct cca gtc gcg gga ccg tca gtc ttc ctc       1728
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu           
                565                 570                 575               

ttc ccc cca aaa ccc aag gac acc ctc atg atc gcc cgg acc cct gag       1776
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu           
            580                 585                 590                   

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag       1824
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
        595                 600                 605                       

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag       1872
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
    610                 615                 620                           

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc       1920
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
625                 630                 635                 640           

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag       1968
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
                645                 650                 655               

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       2016
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
            660                 665                 670                   

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       2064
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
        675                 680                 685                       

cgg gat gag ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       2112
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
    690                 695                 700                           

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       2160
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
705                 710                 715                 720           

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       2208
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
                725                 730                 735               

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       2256
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
            740                 745                 750                   

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       2304
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
        755                 760                 765                       

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa aaa gat ccc       2352
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro           
    770                 775                 780                           

aaa ttt tgg gtg ctg gtg gtg gtt ggt gga gtc ctg gct tgc tat agc       2400
Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser           
785                 790                 795                 800           

ttg cta gta aca gtg gcc ttt att att ttc tgg gtg agg agt aag agg       2448
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg           
                805                 810                 815               

agc agg ctc ctg cac agt gac tac atg aac atg act ccc cgc cgc ccc       2496
Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro           
            820                 825                 830                   

ggg ccc acc cgc aag cat tac cag gcc tat gcc gcc gca cgc gac ttc       2544
Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe           
        835                 840                 845                       

gca gcc tat cgc tcc ctg aga gtg aag ttc agc agg agc gca gac gcc       2592
Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala           
    850                 855                 860                           

ccc gcg tac cag cag ggc cag aac cag ctc tat aac gag ctc aat cta       2640
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu           
865                 870                 875                 880           

gga cga aga gag gag tac gat gtt ttg gac aag aga cgt ggc cgg gac       2688
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp           
                885                 890                 895               

cct gag atg ggg gga aag ccg aga agg aag aac cct cag gaa ggc ctg       2736
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu           
            900                 905                 910                   

tac aat gaa ctg cag aaa gat aag atg gcg gag gcc tac agt gag att       2784
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile           
        915                 920                 925                       

ggg atg aaa ggc gag cgc cgg agg ggc aag ggg cac gat ggc ctt tac       2832
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr           
    930                 935                 940                           

cag ggt ctc agt aca gcc acc aag gac acc tac gac gcc ctt cac atg       2880
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met           
945                 950                 955                 960           

cag gcc ctg ccc cct cgc taa                                           2901
Gln Ala Leu Pro Pro Arg                                                   
                965                                                       


<210>  18
<211>  966
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  18

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gln Val Lys Leu Gln Gln Ser Gly Thr Val Leu 
            20                  25                  30          


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Arg Phe Thr Asn Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Val Ile Tyr Pro Gly Asn Ser Asp Thr Ser 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Glu Gly Glu Gly Ser Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Ala Thr Met Ala Ala Ser Pro Gly Glu Lys Ile Thr Ile Thr Cys Ser 
                165                 170                 175     


Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Phe Ser Pro Lys Leu Leu Ile Tyr Arg Thr Ser Asn Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Ile Gly Thr Met Glu Ala Glu Asp Val Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Gly Ser Ser Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Leu Glu Leu Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val 
    290                 295                 300                 


His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro 
305                 310                 315                 320 


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser 
                325                 330                 335     


Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu 
            340                 345                 350         


Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro 
        355                 360                 365             


Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln 
    370                 375                 380                 


Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
385                 390                 395                 400 


Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp 
                405                 410                 415     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
        435                 440                 445             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    450                 455                 460                 


Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
465                 470                 475                 480 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
                485                 490                 495     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            500                 505                 510         


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
        515                 520                 525             


His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
    530                 535                 540                 


Ile Lys Val Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                565                 570                 575     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu 
            580                 585                 590         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        595                 600                 605             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    610                 615                 620                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
625                 630                 635                 640 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                645                 650                 655     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            660                 665                 670         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        675                 680                 685             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    690                 695                 700                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
705                 710                 715                 720 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                725                 730                 735     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            740                 745                 750         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        755                 760                 765             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro 
    770                 775                 780                 


Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
785                 790                 795                 800 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                805                 810                 815     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            820                 825                 830         


Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe 
        835                 840                 845             


Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    850                 855                 860                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
865                 870                 875                 880 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                885                 890                 895     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            900                 905                 910         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        915                 920                 925             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    930                 935                 940                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
945                 950                 955                 960 


Gln Ala Leu Pro Pro Arg 
                965     


<210>  19
<211>  2937
<212>  DNA
<213>  artificial

<220>
<223>  synthetic molecule


<220>
<221>  CDS
<222>  (1)..(2937)

<400>  19
atg gat ttt cag gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata atg tct aga atg gcc cag gtg caa ctg cag cag tca ggg gct         96
Val Ile Met Ser Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala           
            20                  25                  30                    

gag ctg gct aga cct ggg gct tca gtg aag atg tcc tgc aag gct tct        144
Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser           
        35                  40                  45                        

ggc tac acc ttt act acc tac aca ata cac tgg gta aga cgg agg cct        192
Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Arg Arg Pro           
    50                  55                  60                            

gga cac gat ctg gaa tgg att gga tac att aat cct agc agt gga tgt        240
Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Cys           
65                  70                  75                  80            

tct gac tac aat caa aac ttc aag ggc aag acc aca ttg act gca gac        288
Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp           
                85                  90                  95                

aag tcc tcc aac aca gcc tac atg caa ctg aac agc ctg aca tct gag        336
Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu           
            100                 105                 110                   

gac tct gcg gtc tat tac tgt gca aga aga gcg gac tat ggt aac tac        384
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr           
        115                 120                 125                       

gaa tat acc tgg ttt gct tac tgg ggc caa ggg acc acg gtc acc gtc        432
Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val           
    130                 135                 140                           

tcc tca agt gga ggc ggt tca ggt gga ggt ggc tct ggc ggt ggc gga        480
Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
145                 150                 155                 160           

tcg gtc atc gag ctc act cag tct cca aaa ttc atg tcc aca tca gta        528
Ser Val Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val           
                165                 170                 175               

gga gac agg gtc aac gtc acc tac aag gcc agt cag aat gtg ggt act        576
Gly Asp Arg Val Asn Val Thr Tyr Lys Ala Ser Gln Asn Val Gly Thr           
            180                 185                 190                   

aat gta gcc tgg ttt caa caa aaa cca ggg caa tct cct aaa gtt ctg        624
Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu           
        195                 200                 205                       

att tac tcg gca tct tac cga tac agt gga gtc cct gat cgc ttc aca        672
Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr           
    210                 215                 220                           

ggc agt gga tct gga aca gat ttc act ctc acc atc agc aat gtg cag        720
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln           
225                 230                 235                 240           

tct gaa gac ttg gca gag tat ttc tgt cag caa tat cac acc tat cct        768
Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro           
                245                 250                 255               

ctc acg ttc gga ggg ggc acc aag ctg gaa atc aaa cgg gcg gcc gct        816
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala           
            260                 265                 270                   

ggt ggc ggg gga tct gga gga ggt ggt tcc gga gga ggt ggt tca gga        864
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
        275                 280                 285                       

ggt ggc ggc tcc gga gga ggt gga tca gga ggc ggt ggc agc ggc ggc        912
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
    290                 295                 300                           

gga gga tct ggt ggc ggt ggc tcc gtc gac atg gcg cag gtc cag ctc        960
Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Met Ala Gln Val Gln Leu           
305                 310                 315                 320           

cag gag tcc ggc gga ggc ctg gtg cag cca ggc ggg tcc ctg aag ctg       1008
Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu           
                325                 330                 335               

agc tgt gct gca tcc ggt ttt acc ttt tcc agt tac gga atg tcc tgg       1056
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp           
            340                 345                 350                   

gtt cgc cag acc ccc gat aag cgg ctg gaa ctg gtg gcg aca atc aac       1104
Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala Thr Ile Asn           
        355                 360                 365                       

tcc aat ggc gga tct act tat tac cca gat tct gtt aaa ggc cgt ttt       1152
Ser Asn Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe           
    370                 375                 380                           

acc atc tcc agg gat aac gcc aaa aac acc ctg tat ctg cag atg tct       1200
Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser           
385                 390                 395                 400           

tct ttg aag agt gag gac act gct atg tac tat tgc gcc cgg gat cgt       1248
Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Arg           
                405                 410                 415               

gac ggc tac gat gaa ggt ttc gac tac tgg gga cag ggc aca acc gtc       1296
Asp Gly Tyr Asp Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val           
            420                 425                 430                   

act gtc tct tcc ggc ggt ggt ggc agc ggc ggc ggg gga agc ggc ggg       1344
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
        435                 440                 445                       

ggt ggt tcc gac atc gag ctc acc caa tcc ccc tcc atc atg tcc gcc       1392
Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ser Ile Met Ser Ala           
    450                 455                 460                           

tcc cca ggc gag aag gtc acc atg acc tgc tct gct tct tcc tcc gtg       1440
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val           
465                 470                 475                 480           

tct tac atg cat tgg tac cag cag aaa tct ggt acc tct ccg aaa cgc       1488
Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg           
                485                 490                 495               

tgg atc tat gac acc tct aag ttg gct tcc ggg gtg cca gcc cgg ttc       1536
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe           
            500                 505                 510                   

tct ggc agc gga agt gga acc tcc tac tcc ctc act att tct tct atg       1584
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met           
        515                 520                 525                       

gag gct gaa gac gcc gcg acc tat tat tgt cag caa tgg agc agc aac       1632
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn           
    530                 535                 540                           

ccc cct act ctg ggg cgc cgt act cag ctg cag ctg aaa cgc gcg gat       1680
Pro Pro Thr Leu Gly Arg Arg Thr Gln Leu Gln Leu Lys Arg Ala Asp           
545                 550                 555                 560           

ccc gcc gag ccc aaa tct cct gac aaa act cac aca tgc cca ccg tgc       1728
Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys           
                565                 570                 575               

cca gca cct cca gtc gcg gga ccg tca gtc ttc ctc ttc ccc cca aaa       1776
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
            580                 585                 590                   

ccc aag gac acc ctc atg atc gcc cgg acc cct gag gtc aca tgc gtg       1824
Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val           
        595                 600                 605                       

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac       1872
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
    610                 615                 620                           

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag       1920
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
625                 630                 635                 640           

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac       1968
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
                645                 650                 655               

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa       2016
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
            660                 665                 670                   

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag       2064
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln           
        675                 680                 685                       

ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg       2112
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu           
    690                 695                 700                           

acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc       2160
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro           
705                 710                 715                 720           

agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac       2208
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn           
                725                 730                 735               

tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc       2256
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu           
            740                 745                 750                   

tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc       2304
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val           
        755                 760                 765                       

ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag       2352
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln           
    770                 775                 780                           

aag agc ctc tcc ctg tct ccg ggt aaa aaa gat ccc aaa ttt tgg gtg       2400
Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe Trp Val           
785                 790                 795                 800           

ctg gtg gtg gtt ggt gga gtc ctg gct tgc tat agc ttg cta gta aca       2448
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr           
                805                 810                 815               

gtg gcc ttt att att ttc tgg gtg agg agt aag agg agc agg ctc ctg       2496
Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu           
            820                 825                 830                   

cac agt gac tac atg aac atg act ccc cgc cgc ccc ggg ccc acc cgc       2544
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg           
        835                 840                 845                       

aag cat tac cag gcc tat gcc gcc gca cgc gac ttc gca gcc tat cgc       2592
Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala Ala Tyr Arg           
    850                 855                 860                           

tcc ctg aga gtg aag ttc agc agg agc gca gac gcc ccc gcg tac cag       2640
Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln           
865                 870                 875                 880           

cag ggc cag aac cag ctc tat aac gag ctc aat cta gga cga aga gag       2688
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu           
                885                 890                 895               

gag tac gat gtt ttg gac aag aga cgt ggc cgg gac cct gag atg ggg       2736
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly           
            900                 905                 910                   

gga aag ccg aga agg aag aac cct cag gaa ggc ctg tac aat gaa ctg       2784
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu           
        915                 920                 925                       

cag aaa gat aag atg gcg gag gcc tac agt gag att ggg atg aaa ggc       2832
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly           
    930                 935                 940                           

gag cgc cgg agg ggc aag ggg cac gat ggc ctt tac cag ggt ctc agt       2880
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser           
945                 950                 955                 960           

aca gcc acc aag gac acc tac gac gcc ctt cac atg cag gcc ctg ccc       2928
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro           
                965                 970                 975               

cct cgc taa                                                           2937
Pro Arg                                                                   
                                                                          


<210>  20
<211>  978
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  20

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala 
            20                  25                  30          


Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Arg Arg Pro 
    50                  55                  60                  


Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Cys 
65                  70                  75                  80  


Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
                85                  90                  95      


Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr 
        115                 120                 125             


Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Val Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val 
                165                 170                 175     


Gly Asp Arg Val Asn Val Thr Tyr Lys Ala Ser Gln Asn Val Gly Thr 
            180                 185                 190         


Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu 
        195                 200                 205             


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
225                 230                 235                 240 


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Met Ala Gln Val Gln Leu 
305                 310                 315                 320 


Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
                325                 330                 335     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp 
            340                 345                 350         


Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala Thr Ile Asn 
        355                 360                 365             


Ser Asn Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe 
    370                 375                 380                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser 
385                 390                 395                 400 


Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Arg 
                405                 410                 415     


Asp Gly Tyr Asp Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            420                 425                 430         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ser Ile Met Ser Ala 
    450                 455                 460                 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
465                 470                 475                 480 


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
                485                 490                 495     


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe 
            500                 505                 510         


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
        515                 520                 525             


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
    530                 535                 540                 


Pro Pro Thr Leu Gly Arg Arg Thr Gln Leu Gln Leu Lys Arg Ala Asp 
545                 550                 555                 560 


Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
                565                 570                 575     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            580                 585                 590         


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        595                 600                 605             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    610                 615                 620                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
625                 630                 635                 640 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                645                 650                 655     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            660                 665                 670         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        675                 680                 685             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    690                 695                 700                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
705                 710                 715                 720 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                725                 730                 735     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            740                 745                 750         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        755                 760                 765             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    770                 775                 780                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe Trp Val 
785                 790                 795                 800 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                805                 810                 815     


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
            820                 825                 830         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        835                 840                 845             


Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala Ala Tyr Arg 
    850                 855                 860                 


Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
865                 870                 875                 880 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                885                 890                 895     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            900                 905                 910         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        915                 920                 925             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    930                 935                 940                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
945                 950                 955                 960 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                965                 970                 975     


Pro Arg 
        


<210>  21
<211>  3006
<212>  DNA
<213>  artificial

<220>
<223>  synthetic molecule


<220>
<221>  CDS
<222>  (1)..(2985)

<400>  21
atg gat ttt cag gtg cag att ttc agc ttc ctg cta atc agt gcc tca         48
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser           
1               5                   10                  15                

gtc ata atg tct aga atg gcc cag gtg caa ctg cag cag tca ggg gct         96
Val Ile Met Ser Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala           
            20                  25                  30                    

gag ctg gct aga cct ggg gct tca gtg aag atg tcc tgc aag gct tct        144
Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser           
        35                  40                  45                        

ggc tac acc ttt act acc tac aca ata cac tgg gta aga cgg agg cct        192
Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Arg Arg Pro           
    50                  55                  60                            

gga cac gat ctg gaa tgg att gga tac att aat cct agc agt gga tgt        240
Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Cys           
65                  70                  75                  80            

tct gac tac aat caa aac ttc aag ggc aag acc aca ttg act gca gac        288
Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp           
                85                  90                  95                

aag tcc tcc aac aca gcc tac atg caa ctg aac agc ctg aca tct gag        336
Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu           
            100                 105                 110                   

gac tct gcg gtc tat tac tgt gca aga aga gcg gac tat ggt aac tac        384
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr           
        115                 120                 125                       

gaa tat acc tgg ttt gct tac tgg ggc caa ggg acc acg gtc acc gtc        432
Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val           
    130                 135                 140                           

tcc tca agt gga ggc ggt tca ggt gga ggt ggc tct ggc ggt ggc gga        480
Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
145                 150                 155                 160           

tcg gtc atc gag ctc act cag tct cca aaa ttc atg tcc aca tca gta        528
Ser Val Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val           
                165                 170                 175               

gga gac agg gtc aac gtc acc tac aag gcc agt cag aat gtg ggt act        576
Gly Asp Arg Val Asn Val Thr Tyr Lys Ala Ser Gln Asn Val Gly Thr           
            180                 185                 190                   

aat gta gcc tgg ttt caa caa aaa cca ggg caa tct cct aaa gtt ctg        624
Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu           
        195                 200                 205                       

att tac tcg gca tct tac cga tac agt gga gtc cct gat cgc ttc aca        672
Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr           
    210                 215                 220                           

ggc agt gga tct gga aca gat ttc act ctc acc atc agc aat gtg cag        720
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln           
225                 230                 235                 240           

tct gaa gac ttg gca gag tat ttc tgt cag caa tat cac acc tat cct        768
Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro           
                245                 250                 255               

ctc acg ttc gga ggg ggc acc aag ctg gaa atc aaa cgg gcg gcc gca        816
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala           
            260                 265                 270                   

gga ggc ggg ggt tct ggt gga ggc gga agc ggt ggc ggg ggt tca gga        864
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly           
        275                 280                 285                       

ggc ggg ggt tcc ggt ggt ggc ggc agt ggt ggt ggc ggc agt ggt ggt        912
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
    290                 295                 300                           

ggc ggc agt ggt ggt ggc ggc agt gtc gac ggt gtc cac tcc cag gtg        960
Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Gly Val His Ser Gln Val           
305                 310                 315                 320           

cag att ttc agc ttc ctg cta atc agt gcc tca gtc ata atg tct aga       1008
Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Met Ser Arg           
                325                 330                 335               

atg gcc cag gtg aag ctg cag cag tct ggc gct gag ttg gtg aaa cct       1056
Met Ala Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro           
            340                 345                 350                   

ggg gct tca gtg aag ata tcc tgc aag gct tct ggc tac acc ttc act       1104
Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr           
        355                 360                 365                       

gac cat gct att cac tgg gcg aag cag aag cct gaa cag ggc ctg gaa       1152
Asp His Ala Ile His Trp Ala Lys Gln Lys Pro Glu Gln Gly Leu Glu           
    370                 375                 380                           

tgg att gga tat att tct ccc gga aat gat gat att aag tac aat gag       1200
Trp Ile Gly Tyr Ile Ser Pro Gly Asn Asp Asp Ile Lys Tyr Asn Glu           
385                 390                 395                 400           

aag ttc aag ggc aag gcc aca ctg act gca gac aaa tcc tcc agc act       1248
Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr           
                405                 410                 415               

gcc tac atg cag ctc aac agc ctg aca tct gag gat tct gca gtg tat       1296
Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr           
            420                 425                 430                   

ttc tgt aaa aga tcg tac tac ggc cac tgg ggc caa ggc acc acg gtc       1344
Phe Cys Lys Arg Ser Tyr Tyr Gly His Trp Gly Gln Gly Thr Thr Val           
        435                 440                 445                       

acc gtc tcc tca ggt gga ggc ggt tca ggc gga ggt ggc tct ggc ggt       1392
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly           
    450                 455                 460                           

ggc gga tcg gac atc gag ctc act cag tct cca gcc tcc tta tct gta       1440
Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val           
465                 470                 475                 480           

tct gtg gga gaa act gtc acc atc aca tgt cga gca agt gag aat att       1488
Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile           
                485                 490                 495               

tac agt aat tta gca tgg tac caa cag aaa cag gga aaa tct cct cag       1536
Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln           
            500                 505                 510                   

ctc ctg gtc tat gct gca aca aac tta gca gat ggt gtg cca tca agg       1584
Leu Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg           
        515                 520                 525                       

ttc agt ggc agt gga tcg ggc aca cag tat tcc ctc aag atc aac agc       1632
Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser           
    530                 535                 540                           

ctg cag tct gaa gat ttt ggg agt tat tac tgt caa cat ttt tgg ggt       1680
Leu Gln Ser Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly           
545                 550                 555                 560           

act ccg tac acg ttc gga ggg ggg acc aag ctg gag ctg aaa gtg gat       1728
Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Val Asp           
                565                 570                 575               

ccc gcc gag ccc aaa tct cct gac aaa act cac aca tgc cca ccg tgc       1776
Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys           
            580                 585                 590                   

cca gca cct cca gtc gcg gga ccg tca gtc ttc ctc ttc ccc cca aaa       1824
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
        595                 600                 605                       

ccc aag gac acc ctc atg atc gcc cgg acc cct gag gtc aca tgc gtg       1872
Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val           
    610                 615                 620                           

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac       1920
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
625                 630                 635                 640           

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag       1968
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
                645                 650                 655               

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac       2016
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
            660                 665                 670                   

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa       2064
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
        675                 680                 685                       

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag       2112
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln           
    690                 695                 700                           

ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag ctg       2160
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu           
705                 710                 715                 720           

acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc       2208
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro           
                725                 730                 735               

agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac       2256
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn           
            740                 745                 750                   

tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc       2304
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu           
        755                 760                 765                       

tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc       2352
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val           
    770                 775                 780                           

ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag       2400
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln           
785                 790                 795                 800           

aag agc ctc tcc ctg tct ccg ggt aaa aaa gat ccc aaa ttt tgg gtg       2448
Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe Trp Val           
                805                 810                 815               

ctg gtg gtg gtt ggt gga gtc ctg gct tgc tat agc ttg cta gta aca       2496
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr           
            820                 825                 830                   

gtg gcc ttt att att ttc tgg gtg agg agt aag agg agc agg ctc ctg       2544
Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu           
        835                 840                 845                       

cac agt gac tac atg aac atg act ccc cgc cgc ccc ggg ccc acc cgc       2592
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg           
    850                 855                 860                           

aag cat tac cag gcc tat gcc gcc gca cgc gac ttc gca gcc tat cgc       2640
Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala Ala Tyr Arg           
865                 870                 875                 880           

tcc ctg aga gtg aag ttc agc agg agc gca gac gcc ccc gcg tac cag       2688
Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln           
                885                 890                 895               

cag ggc cag aac cag ctc tat aac gag ctc aat cta gga cga aga gag       2736
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu           
            900                 905                 910                   

gag tac gat gtt ttg gac aag aga cgt ggc cgg gac cct gag atg ggg       2784
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly           
        915                 920                 925                       

gga aag ccg aga agg aag aac cct cag gaa ggc ctg tac aat gaa ctg       2832
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu           
    930                 935                 940                           

cag aaa gat aag atg gcg gag gcc tac agt gag att ggg atg aaa ggc       2880
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly           
945                 950                 955                 960           

gag cgc cgg agg ggc aag ggg cac gat ggc ctt tac cag ggt ctc agt       2928
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser           
                965                 970                 975               

aca gcc acc aag gac acc tac gac gcc ctt cac atg cag gcc ctg ccc       2976
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro           
            980                 985                 990                   

cct cgc taa tcctcgagag atccggatta g                                   3006
Pro Arg                                                                   
                                                                          


<210>  22
<211>  994
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic Construct

<400>  22

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala 
            20                  25                  30          


Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Thr Tyr Thr Ile His Trp Val Arg Arg Arg Pro 
    50                  55                  60                  


Gly His Asp Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Cys 
65                  70                  75                  80  


Ser Asp Tyr Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
                85                  90                  95      


Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr 
        115                 120                 125             


Glu Tyr Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Val Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val 
                165                 170                 175     


Gly Asp Arg Val Asn Val Thr Tyr Lys Ala Ser Gln Asn Val Gly Thr 
            180                 185                 190         


Asn Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu 
        195                 200                 205             


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
225                 230                 235                 240 


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Gly Val His Ser Gln Val 
305                 310                 315                 320 


Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Met Ser Arg 
                325                 330                 335     


Met Ala Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro 
            340                 345                 350         


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        355                 360                 365             


Asp His Ala Ile His Trp Ala Lys Gln Lys Pro Glu Gln Gly Leu Glu 
    370                 375                 380                 


Trp Ile Gly Tyr Ile Ser Pro Gly Asn Asp Asp Ile Lys Tyr Asn Glu 
385                 390                 395                 400 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                405                 410                 415     


Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            420                 425                 430         


Phe Cys Lys Arg Ser Tyr Tyr Gly His Trp Gly Gln Gly Thr Thr Val 
        435                 440                 445             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val 
465                 470                 475                 480 


Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
                485                 490                 495     


Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln 
            500                 505                 510         


Leu Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg 
        515                 520                 525             


Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser 
    530                 535                 540                 


Leu Gln Ser Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly 
545                 550                 555                 560 


Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Val Asp 
                565                 570                 575     


Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
            580                 585                 590         


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        595                 600                 605             


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
    610                 615                 620                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
625                 630                 635                 640 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                645                 650                 655     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            660                 665                 670         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        675                 680                 685             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    690                 695                 700                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
705                 710                 715                 720 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                725                 730                 735     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            740                 745                 750         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        755                 760                 765             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    770                 775                 780                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
785                 790                 795                 800 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys Phe Trp Val 
                805                 810                 815     


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
            820                 825                 830         


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
        835                 840                 845             


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
    850                 855                 860                 


Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala Ala Tyr Arg 
865                 870                 875                 880 


Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                885                 890                 895     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            900                 905                 910         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        915                 920                 925             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    930                 935                 940                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
945                 950                 955                 960 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                965                 970                 975     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            980                 985                 990         


Pro Arg 
        


