                               SEQUENCE LISTING

<110> REGENTS OF THE UNIVERSITY OF MINNESOTA
 
<120> ANTIBODY FRAGMENTS FOR DETECTING CANCER AND METHODS OF USE

<130> 09531.395WO1

<140> PCT/US2015/040044
<141> 2015-07-10

<150> 62/023,354
<151> 2014-07-11

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 828
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
aaggagacag tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc       60

gcggcccagc cggccatggc cgaggtgcag ctgttggagt ctgggggagg cttggtacag      120

cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttag cagctatgcc      180

atgagctggg tccgccaggc tccagggaag gggctggagt gggtctcagc gattagggag      240

gatggtatta agacatatta cgcagactcc gtgaagggcc ggttcaccat ctccagagac      300

aattccaaga acacgctgta tctgcaaatg aacagcctga gagccgagga cacggccgta      360

tattactgtg cgaaaagggc tcgtcggttt gactactggg gccagggaac cctggtcacc      420

gtctcgagcg gtggaggcgg ttcaggcgga ggtggcagcg gcggtggcgg gtcgacggac      480

atccagatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      540

acttgccggg caagtcagag cattagcagc tatttaaatt ggtatcagca gaaaccaggg      600

aaagccccta agctcctgat ctataatgca tcccttttgc aaagtggggt cccatcaagg      660

ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa      720

gattttgcaa cttactactg tcaacagagt ctgcgttcgc ctattacgtt cggccaaggg      780

accaaggtgg aaatcaaacg ggcggccgca catcatcatc accatcac                   828


<210> 2
<211> 271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Arg Glu Asp Gly Ile Lys Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Ala Arg Arg Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Ser Leu Leu 
        195                 200                 205             


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Ser Leu Arg Ser Pro Ile Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg Ala Ala Ala His His His His His His 
            260                 265                 270     


<210> 3
<211> 4258
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      120

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      180

ccagggaagg ggctggagtg ggtctcagcg attagggagg atggtattaa gacatattac      240

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagggct      360

cgtcggtttg actactgggg ccagggaacc ctggtcaccg tctcgagcgc tagcaccaag      420

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      720

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1140

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc cgggtaaatg agtcctagct ggccagacat gataagatac attgatgagt     1440

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     1500

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     1560

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc     1620

tctacaaatg tggtatggaa ttaattctaa aatacagcat agcaaaactt taacctccaa     1680

atcaagcctc tacttgaatc cttttctgag ggatgaataa ggcataggca tcaggggctg     1740

ttgccaatgt gcattagctg tttgcagcct caccttcttt catggagttt aagatatagt     1800

gtattttccc aaggtttgaa ctagctcttc atttctttat gttttaaatg cactgacctc     1860

ccacattccc tttttagtaa aatattcaga aataatttaa atacatcatt gcaatgaaaa     1920

taaatgtttt ttattaggca gaatccagat gctcaaggcc cttcataata tcccccagtt     1980

tagtagttgg acttagggaa caaaggaacc tttaatagaa attggacagc aagaaagcga     2040

gcttctagct tatcctcagt cctgctcctc tgccacaaag tgcacgcagt tgccggccgg     2100

gtcgcgcagg gcgaactccc gcccccacgg ctgctcgccg atctcggtca tggccggccc     2160

ggaggcgtcc cggaagttcg tggacacgac ctccgaccac tcggcgtaca gctcgtccag     2220

gccgcgcacc cacacccagg ccagggtgtt gtccggcacc acctggtcct ggaccgcgct     2280

gatgaacagg gtcacgtcgt cccggaccac accggcgaag tcgtcctcca cgaagtcccg     2340

ggagaacccg agccggtcgg tccagaactc gaccgctccg gcgacgtcgc gcgcggtgag     2400

caccggaacg gcactggtca acttggccat gatggctcct cctgtcagga gaggaaagag     2460

aagaaggtta gtacaattgc tatagtgagt tgtattatac tatgcagata tactatgcca     2520

atgattaatt gtcaaactag ggctgcaggg ttcatagtgc cacttttcct gcactgcccc     2580

atctcctgcc caccctttcc caggcataga cagtcagtga cttaccaaac tcacaggagg     2640

gagaaggcag aagcttgaga cagacccgcg ggaccgccga actgcgaggg gacgtggcta     2700

gggcggcttc ttttatggtg cgccggccct cggaggcagg gcgctcgggg aggcctagcg     2760

gccaatctgc ggtggcagga ggcggggccg aaggccgtgc ctgaccaatc cggagcacat     2820

aggagtctca gccccccgcc ccaaagcaag gggaagtcac gcgcctgtag cgccagcgtg     2880

ttgtgaaatg ggggcttggg ggggttgggg ccctgactag tcaaaacaaa ctcccattga     2940

cgtcaatggg gtggagactt ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga     3000

tgtactgcca aaaccgcatc atcatggtaa tagcgatgac taatacgtag atgtactgcc     3060

aagtaggaaa gtcccataag gtcatgtact gggcataatg ccaggcgggc catttaccgt     3120

cattgacgtc aatagggggc gtacttggca tatgatacac ttgatgtact gccaagtggg     3180

cagtttaccg taaatactcc acccattgac gtcaatggaa agtccctatt ggcgttacta     3240

tgggaacata cgtcattatt gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg     3300

ggccatttac cgtaagttat gtaacgcctg caggttaatt aagaacatgt gagcaaaagg     3360

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     3420

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     3480

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     3540

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     3600

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     3660

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     3720

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     3780

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     3840

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     3900

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     3960

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     4020

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatgg ctagttaatt     4080

aacatttaaa tcagcggccg caataaaata tctttatttt cattacatct gtgtgttggt     4140

tttttgtgtg aatcgtaact aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa     4200

ctagcaaaat aggctgtccc cagtgcaagt gcaggtgcca gaacatttct ctatcgaa       4258


<210> 4
<211> 137
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Arg Glu Asp Gly Ile Lys Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Arg Ala Arg Arg Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135         


<210> 5
<211> 3623
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattca       60

acggacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agacagagtc      120

accatcactt gccgggcaag tcagagcatt agcagctatt taaattggta tcagcagaaa      180

ccagggaaag cccctaagct cctgatctat aatgcatccc ttttgcaaag tggggtccca      240

tcaaggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcaa      300

cctgaagatt ttgcaactta ctactgtcaa cagagtctgc gttcgcctat tacgttcggc      360

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttagag ggagctagct      720

cgacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa      780

atgctttatt tgtgaaattt gtgatgctat tgctttattt gtgaaatttg tgatgctatt      840

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat      900

tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac      960

aaatgtggta tggaattaat tctaaaatac agcatagcaa aactttaacc tccaaatcaa     1020

gcctctactt gaatcctttt ctgagggatg aataaggcat aggcatcagg ggctgttgcc     1080

aatgtgcatt agctgtttgc agcctcacct tctttcatgg agtttaagat atagtgtatt     1140

ttcccaaggt ttgaactagc tcttcatttc tttatgtttt aaatgcactg acctcccaca     1200

ttcccttttt agtaaaatat tcagaaataa tttaaataca tcattgcaat gaaaataaat     1260

gttttttatt aggcagaatc cagatgctca aggcccttca taatatcccc cagtttagta     1320

gttggactta gggaacaaag gaacctttaa tagaaattgg acagcaagaa agcgagcttc     1380

tagctttagt tcctggtgta cttgaggggg atgagttcct caatggtggt tttgaccagc     1440

ttgccattca tctcaatgag cacaaagcag tcaggagcat agtcagagat gagctctctg     1500

cacatgccac aggggctgac caccctgatg gatctgtcca cctcatcaga gtaggggtgc     1560

ctgacagcca caatggtgtc aaagtccttc tgcccgttgc tcacagcaga cccaatggca     1620

atggcttcag cacagacagt gaccctgcca atgtaggcct caatgtggac agcagagatg     1680

atctccccag tcttggtcct gatggccgcc ccgacatggt gcttgttgtc ctcatagagc     1740

atggtgatct tctcagtggc gacctccacc agctccagat cctgctgaga gatgttgaag     1800

gtcttcatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     1860

tagtgagttg tattatacta tgcttatgat taattgtcaa actagggctg cagggttcat     1920

agtgccactt ttcctgcact gccccatctc ctgcccaccc tttcccaggc atagacagtc     1980

agtgacttac caaactcaca ggagggagaa ggcagaagct tgagacagac ccgcgggacc     2040

gccgaactgc gaggggacgt ggctagggcg gcttctttta tggtgcgccg gccctcggag     2100

gcagggcgct cggggaggcc tagcggccaa tctgcggtgg caggaggcgg ggccgaaggc     2160

cgtgcctgac caatccggag cacataggag tctcagcccc ccgccccaaa gcaaggggaa     2220

gtcacgcgcc tgtagcgcca gcgtgttgtg aaatgggggc ttgggggggt tggggccctg     2280

actagtcaaa acaaactccc attgacgtca atggggtgga gacttggaaa tccccgtgag     2340

tcaaaccgct atccacgccc attgatgtac tgccaaaacc gcatcatcat ggtaatagcg     2400

atgactaata cgtagatgta ctgccaagta ggaaagtccc ataaggtcat gtactgggca     2460

taatgccagg cgggccattt accgtcattg acgtcaatag ggggcgtact tggcatatga     2520

tacacttgat gtactgccaa gtgggcagtt taccgtaaat actccaccca ttgacgtcaa     2580

tggaaagtcc ctattggcgt tactatggga acatacgtca ttattgacgt caatgggcgg     2640

gggtcgttgg gcggtcagcc aggcgggcca tttaccgtaa gttatgtaac gcctgcaggt     2700

taattaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     2760

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     2820

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     2880

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     2940

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     3000

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     3060

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     3120

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     3180

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     3240

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     3300

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     3360

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     3420

ggattttggt catggctagt taattaacat ttaaatcagc ggccgcaata aaatatcttt     3480

attttcatta catctgtgtg ttggtttttt gtgtgaatcg taactaacat acgctctcca     3540

tcaaaacaaa acgaaacaaa acaaactagc aaaataggct gtccccagtg caagtgcagg     3600

tgccagaaca tttctctatc gaa                                             3623


<210> 6
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Arg Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 7
His His His His His His 
1               5       


