                         SEQUENCE LISTING



<110>  TDW GROUP
       HE, Wei

       GUO, Yunyun

       WU, Bor-Wen
       
 


<120>  Antibodies to Argininosuccinate Synthase and Related Methods



<130>  TDWG-005/01WO


<150>  US 62/022,066

<151>  2014-07-08



<160>  23    



<170>  PatentIn version 3.5



<210>  1
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH Chain determined by alignment of six productive sub-clones

<400>  1

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  2
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH Chain determined by alignment of six productive sub-clones

<400>  2
cagatccagt tggtgcagtc tggacctgag ttgaagaagc ctggagagac agtcaagatc       60

tcctgcaaga cttctggtta taccttcaca gactattcaa tacactgggt gaagcaggct      120

ccaggaaagg gtttaacgtg gatgggctgg ataaacactg agactggtga gccaacttat      180

gcagatgact tcaagggacg ctttgccctc tctttggaaa cctctgccag cactgcctat      240

ttgcagctca agaacctcag aaatgaggac acggctacat atttctgtgg tagttcttat      300

tcttactggg gccaagggac tctggtcact gtctcttca                             339


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL Chain determined by alignment of five productive sub-clones

<400>  3

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Lys His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  4
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL Chain determined by alignment of five productive sub-clones

<400>  4
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca ggtctagtca gagccttgaa aacagtaatg gaaagaccta tttgaactgg      120

ttcctccaga aaccaggcca gtctccacag ctcctgatct acagggtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga ctgaattcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tatttctgcc tccaagttaa acatgtcccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  5
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
1               5                   10                  15      


Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
            20                  25                  30          


Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
        35                  40                  45              


Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
    50                  55                  60                  


Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
65                  70                  75                  80  


Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                85                  90                  95      


Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
            100                 105                 110         


Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
        115                 120                 125             


Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
    130                 135                 140                 


Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
145                 150                 155                 160 


Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                165                 170                 175     


Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
            180                 185                 190         


Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
        195                 200                 205             


Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu 
    210                 215                 220                 


Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
225                 230                 235                 240 


Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu 
                245                 250                 255     


Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
            260                 265                 270         


Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
        275                 280                 285             


Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
    290                 295                 300                 


Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
305                 310                 315                 320 


Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                325                 330                 335     


Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
            340                 345                 350         


Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
        355                 360                 365             


Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
    370                 375                 380                 


Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
385                 390                 395                 400 


Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                405                 410         


<210>  6
<211>  409
<212>  PRT
<213>  Mycoplasma hominis

<400>  6

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Ile 
    50                  55                  60                  


Met Lys Asp Arg Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Ala Ala Lys Glu Glu Phe Ile Glu 
                85                  90                  95      


Thr Phe Leu Glu Glu Thr Val Pro Val Leu Thr Glu Ala Asn Lys Lys 
            100                 105                 110         


Ala Val Arg Ala Phe Leu Leu Ser Lys Pro Thr His Glu Met Val Glu 
        115                 120                 125             


Phe Met Met Ser Gly Ile Thr Lys Tyr Glu Leu Gly Val Glu Ser Glu 
    130                 135                 140                 


Asn Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp 
145                 150                 155                 160 


Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Phe Met Arg Tyr 
                165                 170                 175     


Ile Val Arg Arg Arg Glu Thr Leu Phe Ala Arg Phe Val Phe Arg Asn 
            180                 185                 190         


His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met Lys 
        195                 200                 205             


Met Pro Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Glu Thr Leu 
    210                 215                 220                 


Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu Leu 
225                 230                 235                 240 


Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile Val 
                245                 250                 255     


Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr Trp 
            260                 265                 270         


Leu Thr Met Leu Asp Lys Asn Lys Phe Leu Tyr Ser Pro Ile Ala Asn 
        275                 280                 285             


Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala Glu 
    290                 295                 300                 


Pro Gln Pro Gln Leu Asn Gly Leu Pro Leu Asp Lys Leu Leu Ala Ser 
305                 310                 315                 320 


Ile Ile Asn Lys Glu Pro Val Leu Ile Pro Ile Gly Gly Ala Gly Ala 
                325                 330                 335     


Thr Glu Met Glu Ile Ala Arg Glu Thr Asn Phe Asp Gly Thr Asn Tyr 
            340                 345                 350         


Leu Ala Ile Lys Pro Gly Leu Val Ile Gly Tyr Asp Arg Asn Glu Lys 
        355                 360                 365             


Thr Asn Ala Ala Leu Lys Ala Ala Gly Ile Thr Val Leu Pro Phe His 
    370                 375                 380                 


Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser Met 
385                 390                 395                 400 


Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 determined by alignment of six productive sub-clones

<400>  7

Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 determined by alignment of six productive sub-clones

<400>  8

Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 determined by alignment of six productive sub-clones

<400>  9

Gly Ser Ser Tyr Ser Tyr 
1               5       


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 determined by alignment of five productive sub-clones

<400>  10

Gln Ser Leu Glu Asn Ser Asn Gly Lys Thr Tyr 
1               5                   10      


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 determined by alignment of five productive sub-clones

<400>  11

Arg Val Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 determined by alignment of five productive sub-clones

<400>  12

Leu Gln Val Lys His Val Pro Trp Thr 
1               5                   


<210>  13
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence from productive sub-clone (6-H6) of hybridoma 
       antibody clone

<400>  13

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence from productive sub-clone (6-C5) of hybridoma 
       antibody clone

<400>  14

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Ser Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence from productive sub-clone (6-C1) of hybridoma 
       antibody clone

<400>  15

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Pro Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence from productive sub-clone (6-L7) of hybridoma 
       antibody clone

<400>  16

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Glu Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence from productive sub-clone (6-A5) of hybridoma 
       antibody clone

<400>  17

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence from productive sub-clone (6-D6) of hybridoma 
       antibody clone

<400>  18

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Thr Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Lys Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Gly Ser Ser Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence from productive sub-clone (4-5) of hybridoma antibody
       clone

<400>  19

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Lys His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence from productive sub-clone (7-2) of hybridoma antibody
       clone

<400>  20

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Lys His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence from productive sub-clone (7-8) of hybridoma antibody
       clone

<400>  21

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Lys His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence from productive sub-clone (7-12) of hybridoma 
       antibody clone

<400>  22

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Pro Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Lys His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence from productive sub-clone (7-4) of hybridoma antibody
       clone

<400>  23

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Thr Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Lys His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


