                         SEQUENCE LISTING

<110>  The Regents of University of California
 
<120>  Invariant Natural Killer T Cell Receptor (iNKT TCR) Gene-Based 
       Immunotherapy

<130>  034044.149WO1

<150>  US 62/022,301
<151>  2014-07-09

<150>  US 62/099,711
<151>  2015-01-05

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  DNA
<213>  Mus musculus

<400>  1
gtg                                                                      3


<210>  2
<211>  3
<212>  DNA
<213>  Mus musculus

<400>  2
gcc                                                                      3


<210>  3
<211>  3
<212>  DNA
<213>  Mus musculus

<400>  3
gcc                                                                      3


<210>  4
<211>  3
<212>  DNA
<213>  Mus musculus

<400>  4
gcc                                                                      3


<210>  5
<211>  0
<212>  DNA
<213>  Mus musculus

<400>  5
000

<210>  6
<211>  3
<212>  DNA
<213>  Mus musculus

<400>  6
gcc                                                                      3


<210>  7
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  7
gtg                                                                      3


<210>  8
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  8
agc                                                                      3


<210>  9
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  9
agc                                                                      3


<210>  10
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  10
agc                                                                      3


<210>  11
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  11
agc                                                                      3


<210>  12
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  12
agc                                                                      3


<210>  13
<211>  3
<212>  DNA
<213>  Homo sapiens

<400>  13
agc                                                                      3


<210>  14
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for iNKT TCR alpha

<400>  14
gggagatact cagcaactct ggataaagat gc                                     32


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for iNKT TCR alpha

<400>  15
ccagattcca tggttttcgg cacattg                                           27


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for iNKT TCR beta

<400>  16
ggagatatcc ctgatggata caaggcctcc                                        30


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for iNKT TCR beta

<400>  17
gggtagcctt ttgtttgttt gcaatctct                                         29


<210>  18
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  18
atgaaaaagc atctgacgac cttcttggtg attttgtggc tttattttta tagggggaat       60

ggcaaaaacc aagtggagca gagtcctcag tccctgatca tcctggaggg aaagaactgc      120

actcttcaat gcaattatac agtgagcccc ttcagcaact taaggtggta taagcaagat      180

actgggagag gtcctgtttc cctgacaatc atgactttca gtgagaacac aaagtcgaac      240

ggaagatata cagcaactct ggatgcagac acaaagcaaa gctctctgca catcacagcc      300

tcccagctca gcgattcagc ctcctacatc tgtgtggtga gcgacagagg ctcaaccctg      360

gggaggctat actttggaag aggaactcag ttgactgtct ggcctgatat ccagaaccct      420

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc      480

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca      540

gacaaaactg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg      600

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac      660

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa      720

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg      780

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagctg a               831


<210>  19
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  19
atgaaaaagc atctgacaac attcctggtc attctgtggc tgtacttcta ccgaggcaac       60

ggcaaaaatc aggtggagca gtccccacag tccctgatca ttctggaggg gaagaactgc      120

actctgcagt gtaattacac cgtgtctccc tttagtaacc tgcgctggta taaacaggac      180

accggacgag gacccgtgag cctgacaatc atgactttct cagagaacac aaagagcaat      240

ggacggtaca ccgctacact ggacgcagat accaaacaga gctccctgca catcacagca      300

tctcagctgt cagatagcgc ctcctacatt tgcgtggtct ctgaccgagg gagtaccctg      360

ggccgactgt attttggaag ggggacccag ctgacagtgt ggcccgacat ccagaaccca      420

gatcccgccg tctaccagct gcgcgacagc aagtctagtg ataaaagcgt gtgcctgttc      480

acagactttg attctcagac taatgtctct cagagtaagg acagtgacgt gtacattact      540

gacaaaaccg tcctggatat gaggagcatg gacttcaagt caaacagcgc cgtggcttgg      600

tcaaacaaga gcgacttcgc atgcgccaat gcttttaaca attcaatcat tccagaggat      660

accttctttc ctagcccaga atcaagctgt gacgtgaagc tggtcgagaa aagtttcgaa      720

actgatacca acctgaattt tcagaacctg tctgtgatcg gcttcagaat cctgctgctg      780

aaggtcgccg gctttaatct gctgatgaca ctgagactgt ggtcctcttg a               831


<210>  20
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Asp Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly 
        115                 120                 125             


Thr Gln Leu Thr Val Trp Pro Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  21
<211>  871
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (337)..(337)
<223>  D/J/N segment

<400>  21
atgactatca ggctcctctg ctacatgggc ttttattttc tgggggcagg cctcatggaa       60

gctgacatct accagacccc aagatacctt gttataggga caggaaagaa gatcactctg      120

gaatgttctc aaaccatggg ccatgacaaa atgtactggt atcaacaaga tccaggaatg      180

gaactacacc tcatccacta ttcctatgga gttaattcca cagagaaggg agatctttcc      240

tctgagtcaa cagtctccag aataaggacg gagcattttc ccctgaccct ggagtctgcc      300

aggccctcac atacctctca gtacctctgt gccagcngag gacctgaaca aggtgttccc      360

acccgaggtc gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac      420

actggtgtgc ctggccacag gcttcttccc tgaccacgtg gagctgagct ggtgggtgaa      480

tgggaaggag gtgcacagtg gggtcagcac ggacccgcag cccctcaagg agcagcccgc      540

cctcaatgac tccagatact gcctgagcag ccgcctgagg gtctcggcca ccttctggca      600

gaacccccgc aaccacttcc gctgccaagt ccagttctac gggctctcgg agaatgacga      660

gtggacccag gatagggcca aacccgtcac ccagatcgtc agcgccgagg cctggggtag      720

agcagactgt ggctttacct cggtgtccta ccagcaaggg gtcctgtctg ccaccatcct      780

ctatgagatc ctgctaggga aggccaccct gtatgctgtg ctggtcagcg cccttgtgtt      840

gatggccatg gtcaagagaa aggatttctg a                                     871


<210>  22
<211>  871
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (337)..(337)
<223>  D/J/N segment

<400>  22
atgaccatcc ggctgctgtg ctacatgggc ttctattttc tgggggcagg cctgatggaa       60

gccgacatct accagactcc cagatacctg gtcatcggaa ccgggaagaa aattacactg      120

gagtgttccc agacaatggg ccacgataag atgtactggt atcagcagga ccctgggatg      180

gaactgcacc tgatccatta ctcctatggc gtgaactcta ccgagaaggg cgacctgagc      240

agcgaatcca ccgtctctcg aattaggaca gagcactttc ctctgactct ggaaagcgcc      300

cgaccaagtc atacatcaca gtacctgtgc gctagcngag gacctgaata aggtgttccc      360

ccctgaggtg gctgtctttg aaccaagtga ggcagaaatt tcacatacac agaaagccac      420

cctggtgtgc ctggctaccg gcttctttcc cgatcacgtg gagctgagct ggtgggtcaa      480

cggcaaggaa gtgcatagcg gagtctccac agacccacag cccctgaaag agcagcctgc      540

tctgaatgat tccagatact gcctgtctag tagactgcgg gtgtctgcca ccttctggca      600

gaacccaagg aatcatttca gatgtcaggt gcagttttat ggcctgagcg agaacgatga      660

atggactcag gacagggcta agccagtgac ccagatcgtc agcgcagagg cctggggaag      720

agcagactgc gggtttacaa gcgtgagcta tcagcagggc gtcctgagcg ccacaatcct      780

gtacgaaatt ctgctgggaa aggccactct gtatgctgtg ctggtctccg ctctggtgct      840

gatggcaatg gtcaagcgga aagatttctg a                                     871


<210>  23
<211>  290
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  D/J/N segment

<400>  23

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


Xaa Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
        115                 120                 125             


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                165                 170                 175     


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
            180                 185                 190         


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
        195                 200                 205             


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
    210                 215                 220                 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
225                 230                 235                 240 


Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu 
                245                 250                 255     


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
            260                 265                 270         


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
        275                 280                 285             


Asp Phe 
    290 


<210>  24
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  24
gtagcggttg ggccccaaga gacccagtac ttcgggccag gcacgcggct cctggtgctc       60


<210>  25
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  25
gtggcagtcg gacctcagga gacccagtac ttcggacccg gcacccgcct gctggtgctg       60


<210>  26
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Ala Val Gly Pro Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
1               5                   10                  15      


Leu Leu Val Leu 
            20  


<210>  27
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  27
agtgggccag ggtacgagca gtacttcggg ccgggcacca ggctcacggt caca             54


<210>  28
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  28
tcaggacccg gctacgagca gtatttcggc cccggaactc ggctgaccgt gacc             54


<210>  29
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Gly Pro Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
1               5                   10                  15      


Val Thr 
        


<210>  30
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  30
agtccccaat taaacactga agctttcttt ggacaaggca ccagactcac agttgta          57


<210>  31
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  31
tctccacagc tgaacaccga ggccttcttc gggcagggca caaggcttac cgtggtg          57


<210>  32
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Pro Gln Leu Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
1               5                   10                  15      


Thr Val Val 
            


<210>  33
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  33
agtgaattgc gggcgctcgg gcccagctcc tataattcac ccctccactt tgggaacggg       60

accaggctca ctgtgaca                                                     78


<210>  34
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  34
tccgaactcc gagccctggg gcctagctcc tacaatagcc ccctgcactt tggcaacgga       60

accaggctga cggtcacc                                                     78


<210>  35
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Glu Leu Arg Ala Leu Gly Pro Ser Ser Tyr Asn Ser Pro Leu His 
1               5                   10                  15      


Phe Gly Asn Gly Thr Arg Leu Thr Val Thr 
            20                  25      


<210>  36
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  36
agtgaacagg ggactactgc gggagctttc tttggacaag gcaccagact cacagttgta       60


<210>  37
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  37
tccgaacagg gaaccacagc aggagccttc ttcggtcagg gaacaagact gacagtcgtg       60


<210>  38
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Glu Gln Gly Thr Thr Ala Gly Ala Phe Phe Gly Gln Gly Thr Arg 
1               5                   10                  15      


Leu Thr Val Val 
            20  


<210>  39
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  39
agtgagtcac gacatgcgac aggaaacacc atatattttg gagagggaag ttggctcact       60

gttgta                                                                  66


<210>  40
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  40
agcgagagca ggcacgcaac cgggaacacc atatactttg gcgagggctc ctggctgact       60

gtggtg                                                                  66


<210>  41
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  41

Ser Glu Ser Arg His Ala Thr Gly Asn Thr Ile Tyr Phe Gly Glu Gly 
1               5                   10                  15      


Ser Trp Leu Thr Val Val 
            20          


<210>  42
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  42
agtgtacccg ggaacgacag gggcaatgaa aaactgtttt ttggcagtgg aacccagctc       60

tctgtcttg                                                               69


<210>  43
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  43
tccgtgcctg gcaacgatag aggtaacgag aagctgtttt tcggatccgg cacacagctg       60

tctgtcctg                                                               69


<210>  44
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Val Pro Gly Asn Asp Arg Gly Asn Glu Lys Leu Phe Phe Gly Ser 
1               5                   10                  15      


Gly Thr Gln Leu Ser Val Leu 
            20              


<210>  45
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  45
agtgaagggg ggggccttaa gctagccaaa aacattcagt acttcggcgc cgggacccgg       60

ctctcagtgc tg                                                           72


<210>  46
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  46
agtgagggag ggggactgaa gctggctaag aatattcagt acttcggcgc cggcactaga       60

ctgtctgtgc tg                                                           72


<210>  47
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Glu Gly Gly Gly Leu Lys Leu Ala Lys Asn Ile Gln Tyr Phe Gly 
1               5                   10                  15      


Ala Gly Thr Arg Leu Ser Val Leu 
            20                  


<210>  48
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  48
agtgaattcg cctcttcggt acgtggaaac accatatatt ttggagaggg aagttggctc       60

actgttgta                                                               69


<210>  49
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  49
tctgagttcg cgagcagcgt ccggggtaat accatttact tcggggaagg cagctggctg       60

accgtggtg                                                               69


<210>  50
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  50

Ser Glu Phe Ala Ser Ser Val Arg Gly Asn Thr Ile Tyr Phe Gly Glu 
1               5                   10                  15      


Gly Ser Trp Leu Thr Val Val 
            20              


<210>  51
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  51
agtgcggcat taggccggga gacccagtac ttcgggccag gcacgcggct cctggtgctc       60


<210>  52
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  52
tctgcagccc ttggccgaga gactcagtac ttcggccctg gcacaagact gctcgtgctc       60


<210>  53
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Ala Ala Leu Gly Arg Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
1               5                   10                  15      


Leu Leu Val Leu 
            20  


<210>  54
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  54
agtgcctccg ggggtgaatc ctacgagcag tacttcgggc cgggcaccag gctcacggtc       60

aca                                                                     63


<210>  55
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  55
agcgcctccg gaggagagtc atacgaacag tatttcggcc ctggcacacg cctcactgtg       60

acc                                                                     63


<210>  56
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Ala Ser Gly Gly Glu Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
1               5                   10                  15      


Arg Leu Thr Val Thr 
            20      


<210>  57
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  57
agcggtcggg tctcgggggg cgattccctc atagcgtttc taggccaaga gacccagtac       60

ttcgggccag gcacgcggct cctggtgctc                                        90


<210>  58
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  58
tcaggacgag tgtccggagg ggatagcctc atcgcatttc tggggcagga aactcagtac       60

ttcggacccg gaacacgcct cctggtgctg                                        90


<210>  59
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Gly Arg Val Ser Gly Gly Asp Ser Leu Ile Ala Phe Leu Gly Gln 
1               5                   10                  15      


Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
            20                  25                  30  


<210>  60
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  60
agtgtacccg ggaacgacag gggcaatgaa aaactgtttt ttggcagtgg aacccagctc       60

tctgtcttg                                                               69


<210>  61
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  61
tccgtgcctg gcaacgatag aggtaacgag aagctgtttt tcggatccgg cacacagctg       60

tctgtcctg                                                               69


<210>  62
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Val Pro Gly Asn Asp Arg Gly Asn Glu Lys Leu Phe Phe Gly Ser 
1               5                   10                  15      


Gly Thr Gln Leu Ser Val Leu 
            20              


