                         SEQUENCE LISTING

<110>  Hadasit Medical Research Services and Development Ltd.
 
<120>  MIR-122 AND REGULATION OF ERYTHROPOIETIN

<130>  HDST040PCT

<150>  US 62/022241
<151>  2014-07-09

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide

<400>  1
uggaguguga caaugguguu ug                                                22


<210>  2
<211>  1548
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  2
gaggatcacc tgaggtcagg agtttgggac cagcctagtc aacatggtga aaccccgtct       60

ctactaaaaa tacaaaaatt agccgggcgt ggtggcgggc acctgtagtc ccagctaccc      120

aggaggctga ggcaggagaa tcgcttgaat ccgggaggcg gaggttgcag tgagccaaga      180

tcacgccact gcactccagc ccgggcaact gagcgagact ccatttcaaa aaaataagta      240

aataaaaaat aaaaagcaat aataatagcc gacaacagaa tacagctagg ccgagcagca      300

gcctcctctg ctgtccgtgc ggctcgcctg ttgcctgctt cactgcctga ctgtgggctc      360

tgtttgtctt ggtccccgtg gcattaccag agcttagcag ataaggagga gcttcataca      420

taattgttgg cgtgaacaaa ggaatgcatg gttaactacg tcagaaatga ccagttcaag      480

aggagaatga gattggcttc caaatgttgg tcaagagctc tacgtagcat gagccaagga      540

tctattgaac ttagtaggct cctgtgaccg gtgactcttc tgtctctaga aatctgggga      600

ggtgaccagg tcatacatgg cagtcttccc gtgaggaacg ttaaactggt tggaagttgg      660

ggttctgagg ggaagatgta ttcactaggt gacctgtctt ctctgcctcg gtggcctcca      720

tggctgcctg ctggccgcac acccccactc agcagaggaa tggactttcc aatcttgctg      780

agtgtgtttg accaaaggtg gtgctgactt agtggcctaa ggtcgtgccc tccctccccc      840

actgaatcga taaataatgc gacttatcag aaagagaaag aattgtttac ttttaaaccc      900

tggatcccat aaagggagag gggagaggcc taaagccaca gaagctgtgg aaggcgccat      960

cctgcctgcc acaggaaggg ccttggactg agaggaccgg agctgactgg gggtaagtgc     1020

ggctctcccc cggcgcctgc cgacccccct gagtgatcag gccgttcttt ggggtggccg     1080

ctgaccgaga aatgacggga ggctgctgac tccggtgttg aaaaagatgc cacccagcgc     1140

ctgagcaaca ggaggtgttg aacacaccat aactttgtct tccatgatta ttctgtttcc     1200

tcagaaagct tgaggaaaac tggagacttt ctttagagag agtaacagat ggtttccgtt     1260

taaagaaaaa taacaaaatg gcttaaggag gaaaagaaat gatcaccctg cagagggaga     1320

gaggatgagg ctggggagga gctgagggct cagggacggt gtggggtttt atttctgccc     1380

ttggagtggc tggacattaa gccagttctt gtttttacga tggcctgatt cagcaataac     1440

accaaacctt caaacaaaat gccggcatta gagtcgttcc tttggcatgc ctctgtccag     1500

gtcatattgt tccctcaata gcactaaaaa tagctggaca cctgtgca                  1548


<210>  3
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  3
caaacaccau ugucacacuc catt                                              24


<210>  4
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  4
ttguuugugg uaacagugug aggu                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  cm

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-Me Adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  cm

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  cm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-Me Adenosine

<400>  5
caaacaccau ugucacacuc catt                                              24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  um

<400>  6
uggaguguga caaugguguu ugtt                                              24


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-Me Adenosine

<400>  7
gacccuucag cuucauauat t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  gm

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<400>  8
uauaugaagc ugaaggguct t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (2)..(3)
<223>  um

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O Me-Adenosine

<400>  9
guuggaggcg guaugugagt t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  2'-O Me-Adenosine

<400>  10
cucacauacc gccuccaact t                                                 21


<210>  11
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  11
gttatgagtg caaaagagcc ag                                                22


<210>  12
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  12
tgcaagtcca gcttgaagag gg                                                22


<210>  13
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  13
tttacctata aggttgctca tagtg                                             25


<210>  14
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  14
gatgggttcc aaccttccc                                                    19


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  15
aaggattgcc tagcagtagc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  16
catggagaag tggaggatgc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  17
ggaagaaaca gtgagaggtg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  18
gccttggact gagaggaccg                                                   20


<210>  19
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  19
gctgtcaacg atacgctacg taacg                                             25


<210>  20
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  20
ctggtgtttg tgtctaaact atcaaacgcc                                        30


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  21
cgctacgtaa cggcatgaca gtg                                               23


<210>  22
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  22
aatacgtact gctaggcaat cc                                                22


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  23
ggacaggact gaacgtcttg c                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  24
caacacttcg tggggtcctt                                                   20


<210>  25
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  25
gtcccagaca ccaaagttaa tttc                                              24


<210>  26
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  26
gccctgccag acttctac                                                     18


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  27
gccttggact gagaggaccg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  28
ggaagaaaca gtgagaggtg                                                   20


<210>  29
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  29
gcgatgatga accaggttat ga                                                22


<210>  30
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  30
atctcgagca agtctttcag tcct                                              24


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  31
cttcactgct tcgggtactg g                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  32
gtgtacagct tcagtttccc c                                                 21


<210>  33
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  33
ccatcaaacg ccattatcac acta                                              24


<210>  34
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  34
cacacaatgg agaactctag cacaa                                             25


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  35
ctgtagccca cgtcgtagca a                                                 21


<210>  36
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  36
ctggcaccac tagttggttg ttc                                               23


<210>  37
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  37
tggagtgtga caatggtgtt tg                                                22


<210>  38
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  38
taaggtgcat ctagtgcaga tag                                               23


<210>  39
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  39
tagcagcacg taaatattgg cg                                                22


<210>  40
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  40
ccuggaugau gauaagcaaa ugcugacuga acaugaaggu cuuaauuagc ucuaacugac       60

u                                                                       61


<210>  41
<211>  106
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  41
gugcucgcuu cggcagcaca uauacuaaaa uuggaacgau acagagaaga uuagcauggc       60

cccugcgcaa ggaugacacg caaauucgug aagcguucca uauuuu                     106


<210>  42
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  42
tcaccgggtg taaatcagct tg                                                22


<210>  43
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  43
gacacgcgta gtcaacatgg tgaaaccc                                          28


<210>  44
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  44
gacctggaca gaggcatgcc aaagg                                             25


<210>  45
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  45
ctcttacgcg tgacctgtct tctctgcctc gg                                     32


<210>  46
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  46
aatggactct cgagtcttgc tgagtgtg                                          28


<210>  47
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  47
caagactcga gagtccattc ctctgctgag                                        30


<210>  48
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  48
atatttggta ccctgccact ctagtac                                           27


<210>  49
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  49
atatttaagc ttgtgtgctc tgctgtctc                                         29


<210>  50
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  50
gctagcctcg agtgaccagg tgtgtccacc                                        30


<210>  51
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  51
aacctgcagg tcgaccctga gatgtcattg ctg                                    33


<210>  52
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  52
gctagcctcg aggtgacatg ctgctgccac c                                      31


<210>  53
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  53
aacctgcagg tcgacagctc tgggaagttc ttctg                                  35


<210>  54
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  54
taaccagagc tcctcttcgt ctctaaccac g                                      31


<210>  55
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  55
accaatctag agctgtttat ttggcag                                           27


<210>  56
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  56
cctctgagct cccaaagccc gagagagtg                                         29


<210>  57
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  57
atgactctag aagaatgcac aaagtactgc                                        30


<210>  58
<211>  216
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  58
agcagagctg tggagtgtga caatggtgtt tgtgtctaaa ctatcaaacg ccattatcac       60

actaaatagc tactgctagg caatccttcc ctcgataaat gtcttggcat cgtttgcttt      120

gagcaagaag gttcatctga tatcagtctt ctcaatcttg tgtacttact gaataaagtc      180

tggctctttt gcactcataa aaaaaaaaaa aaaaaa                                216


<210>  59
<211>  189
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  59
tgccttggac tgagaggacc ggagctgact ggggattatt caaagccaaa agccaacaga       60

gcccccatgg agaagtggag gatgctcaga tactgctatg gagccctgag aagtgaaatg      120

ggtccaagcc cttgcccagg atagagcgct ccaagcgcat cctccgggga cccttttaat      180

cagtgagat                                                              189


<210>  60
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  misc_feature
<222>  (353)..(353)
<223>  n is a, c, g, t or u

<400>  60
tcatggagaa gtggaggatg ctcagatact gctatggagc cctgagaagt gaaatgggtc       60

caagcccttg cccaggatag agcgctccaa gcgcatcctc cggggaccct tttaatcagt      120

gaattgttca cctctcactg tttcttccca gcagagctaa gagacttcta gagcctcttg      180

tggatggtca gcgatagccc tggtcacaat atgtggagct gacaaggttc ccctattatc      240

agtgacaatg gtggaatgtg gaggtgaagt taacaccttc gtggctacag agtttcctta      300

gcagagctgt ggagtgtgac aatggtgttt gtgtctaaac tatcaaacgc cant            354


<210>  61
<211>  7
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  61
ggagugu                                                                  7


<210>  62
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  phosphorothioate linkage;

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  phosphorothioate linkage;

<220>
<221>  modified_base
<222>  (20)..(22)
<223>  phosphorothioate linkage;

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  phosphorothioate linkage; cholesterol linked through a 
       hydroxyprolinol

<400>  62
acacacaaca cugucacauu cca                                               23


<210>  63
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (16)..(18)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  phosphorothioate linkage + cholesterol linked through a 
       hydroxyprolinol

<400>  63
ggcauucacc gcgugccuu                                                    19


<210>  64
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (20)..(22)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  phosphorothioate linkage + cholesterol linked through a 
       hydroxyprolinol

<400>  64
cuaucugcac uagaugcacc uua                                               23


<210>  65
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polynucleotide

<400>  65
gctgtcaacg atacgctacg taacggcatg acagtgtttt tttttttttt tttttttttt       60


