                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       FLEISHMAN, Sarel
       LAPIDOTH, Gideon
       PSZOLLA, Maria Gabriele
       NORN, Christoffer
 
<120>  METHOD OF COMPUTATIONAL PROTEIN DESIGN, PROTEINS DESIGNED 
       THEREWITH AND METHODS OF PRODUCING SAME

<130>  62938

<150>  62/021,309
<151>  2014-07-07

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-ACP-AB   design 1 Nucleotide Sequence

<400>  1
ggtggaggcg gtagcggagg cggagggtcg gaagtgaaac tggacgaaac cggtggtggt       60

ctggttcagc cgggtggtgc gatgaaactg tcttgcgtta cctctggttt cgacttcggt      120

gactactaca tgctgtgggt tcgtcagtct ccggaaaaag gtctggaatg ggttgcggtt      180

gttggtccag acaactctta caccaactac gcggactctg ttaaaggtcg tttcaccatc      240

tctcgtgacg actctaaatc ttctgtttac ctgcagatga acaacctgcg taccgaagac      300

accggtatct actactgcat gggctcttct tggtcccagg actcctcttc cgaatctgtt      360

atgaaatacc tcggtcaggg tacttctgtg accgtttctg gaggtggcgg tagcggaggc      420

ggcggttctg gaggtggcgg gagcaacgtt gttatgaccc agaccccgct gtctctgcca      480

gtttccctgg gtgaccaggc gtctatctct tgccgttctt ctcagtccct caccgcggaa      540

gcgggtctga ccgttctggc ttggttcctg cagaaaccgg gtcagtctcc aaaggtgctg      600

atctacaaag tttctaaccg tgtgtctggt gttccggacc gtttctctgg ttccggttct      660

ggtaccgact tcaccctgaa aatcaaccgc gttgaagctg aagacctcgg tgtttacttc      720

tgcgcggctt ggaccaactc taaatgggtt ttcggtggtg gcaccaagct ggaaattaag      780

ggtggcggat ccgaacaaaa gcttatttct gaagaggact tgtaa                      825


<210>  2
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-ACP-AB   design 2 Nucleotide Sequence

<400>  2
ggtggaggcg gtagcggagg cggagggtcg gaagtgaaac tggacgaaac cggtggtggt       60

ctggttcagc cgggtggtgc gatgaaactg tcttgcgtta cctctggttt cgacttcggt      120

gactactaca tgctgtgggt tcgtcagtct ccggaaaaag gtctggaatg ggttgcggtt      180

gttggtccag acaactctta caccaactac gcggactctg ttaaaggtcg tttcaccatc      240

tctcgtgacg actctaaatc ttctgtttac ctgcagatga acaacctgcg taccgaagac      300

accggtatct actactgcat gggctcttct tggtcccagg actcctcttc cgaatctgtt      360

atgaaatacc tcggtcaggg tacttctgtg accgtttctg gaggtggcgg tagcggaggc      420

ggcggttctg gaggtggcgg gagcaacgtt gttatgaccc agaccccgct gtctctgcca      480

gtttccctgg gtgaccaggc gtctatctct tgccgttctt ctcagtccct caccgcggaa      540

aatggtctga ccgttctggc ttggttcctg cagaaaccgg gtcagtctcc aaaggtgctg      600

atctacaaag tttctaaccg tgtgtctggt gttccggacc gtttctctgg ttccggttct      660

ggtaccgact tcaccctgaa aatcaaccgc gttgaagctg aagacctcgg tgtttacttc      720

tgcgcggctt ggaccaactc taaatgggtt ttcggtggtg gcaccaagct ggaaattaag      780

ggtggcggat ccgaacaaaa gcttatttct gaagaggact tgtaa                      825


<210>  3
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-ACP-AB   design 3 Nucleotide Sequence

<400>  3
ggtggaggcg gtagcggagg cggagggtcg gaagtgaaac tggacgaaac cggtggtggt       60

ctggttcagc cgggtggtgc gatgaaactg tcttgcgtta cctctggttt cgacttcggt      120

gactactaca tgctgtgggt tcgtcagtct ccggaaaaag gtctggaatg ggttgcggtt      180

gttggtccag acaactctta caccaactac gcggactctg ttaaaggtcg tttcaccatc      240

tctcgtgacg actctaaatc ttctgtttac ctgcagatga acaacctgcg taccgaagac      300

accggtatct actactgcat gggctcttct tggtcccagg actcctcttc cgaatctgtt      360

atgaaatacc tcggtcaggg tacttctgtg accgtttctg gaggtggcgg tagcggaggc      420

ggcggttctg gaggtggcgg gagcaacgtt gttatgaccc agaccccgct gtctctgcca      480

gtttccctgg gtgaccaggc gtctatctct tgccgttctt ctcagtccct caccgcggaa      540

gcgggtctga ccgttctggc ttggttcctg cagaaaccgg gtcagtctcc aaaggtgctg      600

atctacaaag tttctaaccg tgtgtctggt gttccggacc gtttctctgg ttccggttct      660

ggtaccgact tcaccctgaa aatcaaccgc gttgaagctg aagacctcgg tgtttacttc      720

tgcgcggctt ggaccaactg gaaatgggtt ttcggtggtg gcaccaagct ggaaattaag      780

ggtggcggat ccgaacaaaa gcttatttct gaagaggact tgtaa                      825


<210>  4
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-ACP-AB   design 4 Nucleotide Sequence

<400>  4
ggtggaggcg gtagcggagg cggagggtcg gaagtgaaac tggacgaaac cggtggtggt       60

ctggttcagc cgggtggtgc gatgaaactg tcttgcgtta cctctggttt cgacttcggt      120

gactactaca tgctgtgggt tcgtcagtct ccggaaaaag gtctggaatg ggttgcgcag      180

ttccgtaaca aaccgtacaa ctacgaaacc tactacgcgg actctgttaa aggtcgtttc      240

accatctctc gtgacgactc taaatcttct gtttacctgc agatgaacaa cctgcgtacc      300

gaagacaccg gtatctacta ctgcatgggc tcttcttggt cccaggactc ctcttccgaa      360

tctgttatga aatacctcgg tcagggtact tctgtgaccg tttctggagg tggcggtagc      420

ggaggcggcg gttctggagg tggcgggagc aacgttgtta tgacccagac cccgctgtct      480

ctgccagttt ccctgggtga ccaggcgtct atctcttgcc gttcttctca gtccctcacc      540

gcggaagcgg gtctgaccgt tctggcttgg ttcctgcaga aaccgggtca gtctccaaag      600

gtgctgatct acaaagtttc taaccgtgtg tctggtgttc cggaccgttt ctctggttcc      660

ggttctggta ccgacttcac cctgaaaatc aaccgcgttg aagctgaaga cctcggtgtt      720

tacttctgcg cggcttggac caactctaaa tgggttttcg gtggtggcac caagctggaa      780

attaagggtg gcggatccga acaaaagctt atttctgaag aggacttgta a               831


<210>  5
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-ACP-AB   design 5 Nucleotide Sequence

<400>  5
ggtggaggcg gtagcggagg cggagggtcg gaagtgaaac tggacgaaac cggtggtggt       60

ctggttcagc cgggtggtgc gatgaaactg tcttgcgtta cctctggttt cgacttcggt      120

gactactaca tgctgtgggt tcgtcagtct ccggaaaaag gtctggaatg ggttgcggtt      180

gttggtccag acaactctta caccaactac gcggactctg ttaaaggtcg tttcaccatc      240

tctcgtgacg actctaaatc ttctgtttac ctgcagatga acaacctgcg taccgaagac      300

accggtatct attactgtac tggtgcgtct tacggtatgg aatacctggg tcagggtact      360

tctgtgaccg tttctggagg tggcggtagc ggaggcggcg gttctggagg tggcgggagc      420

aacgttgtta tgacccagac cccgctgtct ctgccagttt ccctgggtga ccaggcgtct      480

atctcttgcc gttcttctca gtccctcacc gcggaagcgg gtctgaccgt tctggcttgg      540

ttcctgcaga aaccgggtca gtctccaaag gtgctgatct acaaagtttc taaccgtgtg      600

tctggtgttc cggaccgttt ctctggttcc ggttctggta ccgacttcac cctgaaaatc      660

aaccgcgttg aagctgaaga cctcggtgtt tacttctgcg cggcttggac caactctaaa      720

tgggttttcg gtggtggcac caagctggaa attaagggtg gcggatccga acaaaagctt      780

atttctgaag aggacttgta a                                                801


<210>  6
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Design #6  Amino Acid coding sequence

<400>  6

Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly 
1               5                   10                  15      


Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu 
            20                  25                  30          


Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu Lys 
        35                  40                  45              


Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile 
    50                  55                  60                  


Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala 
65                  70                  75                  80  


Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu 
                85                  90                  95      


Trp Tyr Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu 
            100                 105                 110         


Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly 
        115                 120                 125             


Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr Pro 
    130                 135                 140                 


Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu Ala Thr 
145                 150                 155                 160 


Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Asp Gly Glu 
                165                 170                 175     


Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val 
            180                 185                 190         


Cys Ile Gly His Ser Asp Asp Thr Asp Asp Ile Ser Tyr Leu Thr Ala 
        195                 200                 205             


Leu Ala Ala Arg Gly Tyr Leu Ile Ala Phe Asp Arg Phe Gly His Gln 
    210                 215                 220                 


Gly Met Asn Gly Ala Pro Thr Asp Glu Glu Arg Ile Arg Thr Leu Val 
225                 230                 235                 240 


Ala Leu Leu Arg Asp Gly Tyr Glu Lys Gln Ile Leu Leu Ser Asn Asp 
                245                 250                 255     


Trp Leu Phe Gly Tyr Ser Ser Tyr Thr Thr Asn Ile Met Asp Val Met 
            260                 265                 270         


Asp Arg Tyr Asn Pro Asp Gly Met Ala His Ile Pro Leu Arg Val Ile 
        275                 280                 285             


Pro His Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
    290                 295                 300                 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
305                 310                 315                 320 


<210>  7
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Design #7  Amino Acid coding sequence

<400>  7

Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly 
1               5                   10                  15      


Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu 
            20                  25                  30          


Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu Lys 
        35                  40                  45              


Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile 
    50                  55                  60                  


Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala 
65                  70                  75                  80  


Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu 
                85                  90                  95      


Trp Tyr Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu 
            100                 105                 110         


Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly 
        115                 120                 125             


Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr Pro 
    130                 135                 140                 


Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu Ala Thr 
145                 150                 155                 160 


Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Asp Gly Glu 
                165                 170                 175     


Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val 
            180                 185                 190         


Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala 
        195                 200                 205             


Leu Ala Ala Arg Gly Tyr Phe Val Ser Phe Asp Arg Ile Ala Leu Ile 
    210                 215                 220                 


Lys Tyr Ala Pro Glu Ser Ala Arg Ile Ala Leu Ile Leu Tyr Leu Val 
225                 230                 235                 240 


Ser Glu Gly Phe Glu Asn Gln Ile Leu Val Ser Gly Asp Trp Leu Phe 
                245                 250                 255     


Gly Phe Ser Ser Tyr Thr Thr Asn Ile Met Asp Asn Met Asp Arg Val 
            260                 265                 270         


Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Tyr Leu 
        275                 280                 285             


Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr 
    290                 295                 300                 


Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
305                 310                 315         


<210>  8
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM-barrel fold Design #8  Amino Acid coding sequence

<400>  8

Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      


Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Val 
            20                  25                  30          


Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              


Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  


Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  


Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      


Trp Ile Phe Val Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         


Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             


Thr Leu Asn Lys Ala Gly Phe Val Lys Ile Ala Ala Asp Gln Pro Gly 
    130                 135                 140                 


Ile Thr Lys Asp Val Glu Lys Val Ile Arg Ala Ala Ala Arg Ala Ser 
145                 150                 155                 160 


Lys Glu Thr Gly Cys Pro Ile Ile Ser His Ser Asn Ala His Asn Asn 
                165                 170                 175     


Asp Gly Glu Ala Gln Gln Glu Ile Leu Ala Cys Glu Gly Val Asp Pro 
            180                 185                 190         


Cys Lys Ile Leu Ile Gly His Leu Gly Asp Thr Asp Asn Leu Asp Tyr 
        195                 200                 205             


Ile Arg Lys Ile Ala Gln Arg Gly Ser Phe Ile Gly Ile Asp Arg Ile 
    210                 215                 220                 


Pro His Ser Gly Ile Gly Ala Glu Gly Asn Ala Ser Ala Ser Ala Leu 
225                 230                 235                 240 


Phe Gly Asn Arg Ser Trp Gln Glu Arg Ala Ser Val Ile Lys Ala Met 
                245                 250                 255     


Ile Asp Asp Gly Tyr Ala Asp Lys Ile Leu Met Ser His Asp Tyr Cys 
            260                 265                 270         


Cys Thr Phe Asp Val Gly Ala Ala Lys Pro Glu Tyr Lys Pro Ser Met 
        275                 280                 285             


Ala Pro Arg Trp Ser Ile Thr Val Ile Phe Glu Asp Thr Ile Pro Phe 
    290                 295                 300                 


Leu Lys Arg Asn Gly Val Asn Glu Glu Val Leu Ala Thr Ile Phe Lys 
305                 310                 315                 320 


Glu Asn Pro Lys Lys Phe Phe Ser 
                325             


<210>  9
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM-barrel fold Design #9  Amino Acid coding sequence

<400>  9

Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      


Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Val 
            20                  25                  30          


Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              


Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  


Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  


Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      


Trp Ile Phe Val Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         


Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             


Thr Leu Asn Lys Ala Gly Phe Ile Lys Leu Ala Ser Ser Lys Gly Arg 
    130                 135                 140                 


Ile Thr Pro Tyr Glu Glu Lys Val Leu Arg Ala Ala Ala Arg Ala Gln 
145                 150                 155                 160 


Lys Glu Thr Gly Ala Pro Ile Ile Ser His Thr Gln Glu Gly Gln Gln 
                165                 170                 175     


Gly Pro Gln Gln Ala Glu Leu Leu Lys Gln Glu Gly Ala Asp Pro Glu 
            180                 185                 190         


Lys Ile Leu Ile Gly His Ser Asp Asp Thr Asp Asp Leu Asp Trp Ile 
        195                 200                 205             


Arg Lys Met Ala Ala Leu Gly Ser Phe Ile Gly Phe Asp Arg Ile Pro 
    210                 215                 220                 


His Ser Gly Ile Gly Ala Glu Asp Asn Ala Ser Ala Thr Ala Leu Phe 
225                 230                 235                 240 


Gly Asn Arg Ser Asp Gln Glu Arg Ala Arg Ile Ile Lys Ala Met Ile 
                245                 250                 255     


Asp Glu Gly Phe Ala Asn Lys Val Ile Met Ser His Asp Tyr Cys Cys 
            260                 265                 270         


Thr Phe Asp Val Gly Thr Ala Lys Pro Glu Tyr Lys Pro Ser Ala Ala 
        275                 280                 285             


Pro Arg Trp Ser Ile Thr Leu Met Phe Glu Asp Thr Ile Pro Phe Leu 
    290                 295                 300                 


Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile Phe Lys Glu 
305                 310                 315                 320 


Asn Pro Lys Lys Phe Phe Ser 
                325         


<210>  10
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM-barrel fold Design #10  Amino Acid coding sequence

<400>  10

Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      


Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Val 
            20                  25                  30          


Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              


Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  


Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  


Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      


Trp Ile Phe Val Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         


Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             


Thr Leu Asn Lys Ala Gly Phe Ile Lys Val Ala Thr Thr Gly Lys Ala 
    130                 135                 140                 


Thr Pro Asp Glu Glu Lys Val Ile Arg Ala Ala Ala Arg Ala Ser Lys 
145                 150                 155                 160 


Glu Thr Gly Cys Pro Ile Ile Thr His Thr Ala Ala Ser Gln Arg Asp 
                165                 170                 175     


Gly Glu Glu Gln Ala Glu Ile Glu Glu Cys Glu Gly Gly Pro Pro Cys 
            180                 185                 190         


Arg Ile Met Ile Gly His Ser Asp Asp Thr Asp Asp Leu Asp Trp Ile 
        195                 200                 205             


Arg Lys Leu Ala Gln Lys Gly Tyr Phe Ile Gly Phe Asp Arg Met Pro 
    210                 215                 220                 


His Ser Gly Ile Gly Ala Glu Asp Asn Ala Ser Ala Thr Ala Leu Phe 
225                 230                 235                 240 


Gly Thr Arg Ser Asp Gln Thr Arg Asn Glu Ala Ile Lys Arg Ile Ile 
                245                 250                 255     


Asp Asp Gly Tyr Ala Glu Lys Ile Leu Met Ser His Asp Tyr Cys Cys 
            260                 265                 270         


Thr Ile Asp Val Gly Ala Ala Lys Pro Glu His Lys Pro Ser Ala Ala 
        275                 280                 285             


Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile Pro Phe Leu 
    290                 295                 300                 


Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile Phe Lys Glu 
305                 310                 315                 320 


Asn Pro Lys Lys Phe Phe Ser 
                325         


<210>  11
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM-barrel fold Design #11  Amino Acid coding sequence

<400>  11

Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      


Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Val 
            20                  25                  30          


Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              


Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  


Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  


Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      


Trp Ile Phe Val Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         


Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             


Thr Leu Asn Lys Ala Gly Met Ile Ala Glu Ile Gly Thr Ser Glu Gly 
    130                 135                 140                 


Glu Met Ala Pro Glu Glu Glu Lys Leu Leu Arg Ala Ala Ala Gln Ala 
145                 150                 155                 160 


Ala Asn Glu Thr Gly Arg Pro Ile Thr Thr His Thr Ala Ala Ser Gln 
                165                 170                 175     


Arg Val Gly Asp Glu Val Ala Arg Val Leu Glu Glu Gly Gly Val Pro 
            180                 185                 190         


Pro Cys Lys Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Asp 
        195                 200                 205             


Trp Ile Arg Lys Leu Ala Ala Arg Gly Tyr Phe Ile Gly Phe Asp Arg 
    210                 215                 220                 


Ile Gly His Ser Gly Ile Gly Ala Glu Asp Asn Ala Ser Ala Ser Ala 
225                 230                 235                 240 


Leu Ala Gly Asn Arg Ser Asp Gln Thr Arg Ala Glu Cys Val Lys Arg 
                245                 250                 255     


Met Ala Asp Glu Gly Phe Ala Glu Lys Ile Met Val Ser His Asp Tyr 
            260                 265                 270         


Cys Cys Thr Ile Asp Val Gly Thr Ala Lys Pro Glu Tyr Lys Pro Ser 
        275                 280                 285             


Ala Ala Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile Pro 
    290                 295                 300                 


Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile Phe 
305                 310                 315                 320 


Lys Glu Asn Pro Lys Lys Phe Phe Ser 
                325                 


<210>  12
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM-barrel fold Design #12  Amino Acid coding sequence

<400>  12

Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      


Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Val 
            20                  25                  30          


Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              


Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  


Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  


Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      


Trp Ile Phe Val Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         


Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             


Thr Leu Asn Lys Ala Gly Met Ile Ala Glu Ile Gly Thr Ser Glu Gly 
    130                 135                 140                 


Glu Cys Ala Pro Glu Gln Glu Lys Ala Leu Arg Ala Ala Ala Gln Ala 
145                 150                 155                 160 


Ala Asn Glu Thr Gly Arg Pro Ile Thr Thr His Thr Ala Ala Ser Gln 
                165                 170                 175     


Arg Thr Gly Glu Glu Gln Ala Arg Val Leu Glu Cys Gly Gly Val Pro 
            180                 185                 190         


Gly Cys Lys Ile Cys Ile Gly His Met Cys Gly Asn Thr Asp Leu Glu 
        195                 200                 205             


Gln His Arg Lys Leu Ala Asp Arg Gly Tyr Phe Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ile Gly His Ser Gly Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala 
225                 230                 235                 240 


Leu Met Gly Asn Arg Ser Trp Gln Glu Arg Ala Glu Leu Ile Lys Ala 
                245                 250                 255     


Ile Ile Asp Glu Gly Tyr Ala Asp Lys Ile Met Val Ser His Asp Tyr 
            260                 265                 270         


Cys Cys Thr Ile Asp Val Gly Ala Ala Lys Pro Glu Tyr Lys Pro Lys 
        275                 280                 285             


Met Ala Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile Pro 
    290                 295                 300                 


Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile Phe 
305                 310                 315                 320 


Lys Glu Asn Pro Lys Lys Phe Phe Ser 
                325                 


<210>  13
<211>  314
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  13

Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      


Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Val 
            20                  25                  30          


Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              


Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  


Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  


Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      


Tyr Ile Tyr Ile Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         


Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             


Thr Leu Asn Lys Ala Gly Phe Val Lys Ile Ala Ala Asp Glu Pro Gly 
    130                 135                 140                 


Ile Thr Lys Asp Val Glu Lys Val Ile Arg Ala Ala Ala Ile Ala Asn 
145                 150                 155                 160 


Lys Glu Thr Lys Val Pro Ile Ile Thr His Ser Asn Ala His Asn Asn 
                165                 170                 175     


Thr Gly Leu Glu Gln Gln Arg Ile Leu Thr Glu Glu Gly Val Asp Pro 
            180                 185                 190         


Gly Lys Ile Leu Ile Gly His Leu Gly Asp Thr Asp Asn Ile Asp Tyr 
        195                 200                 205             


Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Ile Gly Leu Asp Arg Tyr 
    210                 215                 220                 


Gly Leu Asp Leu Phe Leu Pro Val Asp Lys Arg Asn Glu Thr Thr Leu 
225                 230                 235                 240 


Arg Leu Ile Lys Asp Gly Tyr Ser Asp Lys Ile Met Ile Ser His Asp 
                245                 250                 255     


Tyr Cys Cys Thr Ile Asp Trp Gly Thr Ala Lys Pro Glu Tyr Lys Pro 
            260                 265                 270         


Lys Leu Ala Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile 
        275                 280                 285             


Pro Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile 
    290                 295                 300                 


Phe Lys Glu Asn Pro Lys Lys Phe Phe Ser 
305                 310                 


