                         SEQUENCE LISTING

<110>  ISIS INNOVATION LIMITED
 
<120>  TREATMENT OF LYSOSOMAL DISORDERS (IL-1 ANTAGONISTS)

<130>  N402771WO

<150>  GB1412410.1
<151>  2014-07-11

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  807
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcagaag tacctgagct cgccagtgaa atgatggctt attacagtgg caatgaggat       60

gacttgttct ttgaagctga tggccctaaa cagatgaagt gctccttcca ggacctggac      120

ctctgccctc tggatggcgg catccagcta cgaatctccg accaccacta cagcaagggc      180

ttcaggcagg ccgcgtcagt tgttgtggcc atggacaagc tgaggaagat gctggttccc      240

tgcccacaga ccttccagga gaatgacctg agcaccttct ttcccttcat ctttgaagaa      300

gaacctatct tcttcgacac atgggataac gaggcttatg tgcacgatgc acctgtacga      360

tcactgaact gcacgctccg ggactcacag caaaaaagct tggtgatgtc tggtccatat      420

gaactgaaag ctctccacct ccagggacag gatatggagc aacaagtggt gttctccatg      480

tcctttgtac aaggagaaga aagtaatgac aaaatacctg tggccttggg cctcaaggaa      540

aagaatctgt acctgtcctg cgtgttgaaa gatgataagc ccactctaca gctggagagt      600

gtagatccca aaaattaccc aaagaagaag atggaaaagc gatttgtctt caacaagata      660

gaaatcaata acaagctgga atttgagtct gcccagttcc ccaactggta catcagcacc      720

tctcaagcag aaaacatgcc cgtcttcctg ggagggacca aaggcggcca ggatataact      780

gacttcacca tgcaatttgt gtcttcc                                          807


<210>  2
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  2
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag       1498


<210>  3
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  4
<211>  1710
<212>  DNA
<213>  Homo sapiens

<400>  4
atgaaagtgt tactcagact tatttgtttc atagctctac tgatttcttc tctggaggct       60

gataaatgca aggaacgtga agaaaaaata attttagtgt catctgcaaa tgaaattgat      120

gttcgtccct gtcctcttaa cccaaatgaa cacaaaggca ctataacttg gtataaagat      180

gacagcaaga cacctgtatc tacagaacaa gcctccagga ttcatcaaca caaagagaaa      240

ctttggtttg ttcctgctaa ggtggaggat tcaggacatt actattgcgt ggtaagaaat      300

tcatcttact gcctcagaat taaaataagt gcaaaatttg tggagaatga gcctaactta      360

tgttataatg cacaagccat atttaagcag aaactacccg ttgcaggaga cggaggactt      420

gtgtgccctt atatggagtt ttttaaaaat gaaaataatg agttacctaa attacagtgg      480

tataaggatt gcaaacctct acttcttgac aatatacact ttagtggagt caaagatagg      540

ctcatcgtga tgaatgtggc tgaaaagcat agagggaact atacttgtca tgcatcctac      600

acatacttgg gcaagcaata tcctattacc cgggtaatag aatttattac tctagaggaa      660

aacaaaccca caaggcctgt gattgtgagc ccagctaatg agacaatgga agtagacttg      720

ggatcccaga tacaattgat ctgtaatgtc accggccagt tgagtgacat tgcttactgg      780

aagtggaatg ggtcagtaat tgatgaagat gacccagtgc taggggaaga ctattacagt      840

gtggaaaatc ctgcaaacaa aagaaggagt accctcatca cagtgcttaa tatatcggaa      900

attgaaagta gattttataa acatccattt acctgttttg ccaagaatac acatggtata      960

gatgcagcat atatccagtt aatatatcca gtcactaatt tccagaagca catgattggt     1020

atatgtgtca cgttgacagt cataattgtg tgttctgttt tcatctataa aatcttcaag     1080

attgacattg tgctttggta cagggattcc tgctatgatt ttctcccaat aaaagcttca     1140

gatggaaaga cctatgacgc atatatactg tatccaaaga ctgttgggga agggtctacc     1200

tctgactgtg atatttttgt gtttaaagtc ttgcctgagg tcttggaaaa acagtgtgga     1260

tataagctgt tcatttatgg aagggatgac tacgttgggg aagacattgt tgaggtcatt     1320

aatgaaaacg taaagaaaag cagaagactg attatcattt tagtcagaga aacatcaggc     1380

ttcagctggc tgggtggttc atctgaagag caaatagcca tgtataatgc tcttgttcag     1440

gatggaatta aagttgtcct gcttgagctg gagaaaatcc aagactatga gaaaatgcca     1500

gaatcgatta aattcattaa gcagaaacat ggggctatcc gctggtcagg ggactttaca     1560

cagggaccac agtctgcaaa gacaaggttc tggaagaatg tcaggtacca catgccagtc     1620

cagcgacggt caccttcatc taaacaccag ttactgtcac cagccactaa ggagaaactg     1680

caaagagagg ctcacgtgcc tctcgggtag                                      1710


<210>  5
<211>  5170
<212>  DNA
<213>  Homo sapiens

<400>  5
gtggccggcg gccggagccg actcggagcg cgcggcgccg gccgggagga gccggagagc       60

ggccgggccg ggcggtgggg gcgccggcct gccccgcgcg ccccagggag cggcaggaat      120

gtgacaatcg cgcgcccgcg caccgaagca ctcctcgctc ggctcctagg gctctcgccc      180

ctctgagctg agccgggttc cgcccggggc tgggatccca tcaccctcca cggccgtccg      240

tccaggtaga cgcaccctct gaagatggtg actccctcct gagaagctgg accccttggt      300

aaaagacaag gccttctcca agaagaatat gaaagtgtta ctcagactta tttgtttcat      360

agctctactg atttcttctc tggaggctga taaatgcaag gaacgtgaag aaaaaataat      420

tttagtgtca tctgcaaatg aaattgatgt tcgtccctgt cctcttaacc caaatgaaca      480

caaaggcact ataacttggt ataaagatga cagcaagaca cctgtatcta cagaacaagc      540

ctccaggatt catcaacaca aagagaaact ttggtttgtt cctgctaagg tggaggattc      600

aggacattac tattgcgtgg taagaaattc atcttactgc ctcagaatta aaataagtgc      660

aaaatttgtg gagaatgagc ctaacttatg ttataatgca caagccatat ttaagcagaa      720

actacccgtt gcaggagacg gaggacttgt gtgcccttat atggagtttt ttaaaaatga      780

aaataatgag ttacctaaat tacagtggta taaggattgc aaacctctac ttcttgacaa      840

tatacacttt agtggagtca aagataggct catcgtgatg aatgtggctg aaaagcatag      900

agggaactat acttgtcatg catcctacac atacttgggc aagcaatatc ctattacccg      960

ggtaatagaa tttattactc tagaggaaaa caaacccaca aggcctgtga ttgtgagccc     1020

agctaatgag acaatggaag tagacttggg atcccagata caattgatct gtaatgtcac     1080

cggccagttg agtgacattg cttactggaa gtggaatggg tcagtaattg atgaagatga     1140

cccagtgcta ggggaagact attacagtgt ggaaaatcct gcaaacaaaa gaaggagtac     1200

cctcatcaca gtgcttaata tatcggaaat tgaaagtaga ttttataaac atccatttac     1260

ctgttttgcc aagaatacac atggtataga tgcagcatat atccagttaa tatatccagt     1320

cactaatttc cagaagcaca tgattggtat atgtgtcacg ttgacagtca taattgtgtg     1380

ttctgttttc atctataaaa tcttcaagat tgacattgtg ctttggtaca gggattcctg     1440

ctatgatttt ctcccaataa aagcttcaga tggaaagacc tatgacgcat atatactgta     1500

tccaaagact gttggggaag ggtctacctc tgactgtgat atttttgtgt ttaaagtctt     1560

gcctgaggtc ttggaaaaac agtgtggata taagctgttc atttatggaa gggatgacta     1620

cgttggggaa gacattgttg aggtcattaa tgaaaacgta aagaaaagca gaagactgat     1680

tatcatttta gtcagagaaa catcaggctt cagctggctg ggtggttcat ctgaagagca     1740

aatagccatg tataatgctc ttgttcagga tggaattaaa gttgtcctgc ttgagctgga     1800

gaaaatccaa gactatgaga aaatgccaga atcgattaaa ttcattaagc agaaacatgg     1860

ggctatccgc tggtcagggg actttacaca gggaccacag tctgcaaaga caaggttctg     1920

gaagaatgtc aggtaccaca tgccagtcca gcgacggtca ccttcatcta aacaccagtt     1980

actgtcacca gccactaagg agaaactgca aagagaggct cacgtgcctc tcgggtagca     2040

tggagaagtt gccaagagtt ctttaggtgc ctcctgtctt atggcgttgc aggccaggtt     2100

atgcctcatg ctgacttgca gagttcatgg aatgtaacta tatcatcctt tatccctgag     2160

gtcacctgga atcagattat taagggaata agccatgacg tcaatagcag cccagggcac     2220

ttcagagtag agggcttggg aagatctttt aaaaaggcag taggcccggt gtggtggctc     2280

acgcctataa tcccagcact ttgggaggct gaagtgggtg gatcaccaga ggtcaggagt     2340

tcgagaccag cccagccaac atggcaaaac cccatctcta ctaaaaatac aaaaatgagc     2400

taggcatggt ggcacacgcc tgtaatccca gctacacctg aggctgaggc aggagaattg     2460

cttgaaccgg ggagacggag gttgcagtga gccgagtttg ggccactgca ctctagcctg     2520

gcaacagagc aagactccgt ctcaaaaaaa gggcaataaa tgccctctct gaatgtttga     2580

actgccaaga aaaggcatgg agacagcgaa ctagaagaaa gggcaagaag gaaatagcca     2640

ccgtctacag atggcttagt taagtcatcc acagcccaag ggcggggcta tgccttgtct     2700

ggggaccctg tagagtcact gaccctggag cggctctcct gagaggtgct gcaggcaaag     2760

tgagactgac acctcactga ggaagggaga catattcttg gagaactttc catctgcttg     2820

tattttccat acacatcccc agccagaagt tagtgtccga agaccgaatt ttattttaca     2880

gagcttgaaa actcacttca atgaacaaag ggattctcca ggattccaaa gttttgaagt     2940

catcttagct ttccacagga gggagagaac ttaaaaaagc aacagtagca gggaattgat     3000

ccacttctta atgctttcct ccctggcatg accatcctgt cctttgttat tatcctgcat     3060

tttacgtctt tggaggaaca gctccctagt ggcttcctcc gtctgcaatg tcccttgcac     3120

agcccacaca tgaaccatcc ttcccatgat gccgctcttc tgtcatcccg ctcctgctga     3180

aacacctccc aggggctcca cctgttcagg agctgaagcc catgctttcc caccagcatg     3240

tcactcccag accacctccc tgccctgtcc tccagcttcc cctcgctgtc ctgctgtgtg     3300

aattcccagg ttggcctggt ggccatgtcg cctgccccca gcactcctct gtctctgctc     3360

ttgcctgcac ccttcctcct cctttgccta ggaggccttc tcgcattttc tctagctgat     3420

cagaatttta ccaaaattca gaacatcctc caattccaca gtctctggga gactttccct     3480

aagaggcgac ttcctctcca gccttctctc tctggtcagg cccactgcag agatggtggt     3540

gagcacatct gggaggctgg tctccctcca gctggaattg ctgctctctg agggagaggc     3600

tgtggtggct gtctctgtcc ctcactgcct tccaggagca atttgcacat gtaacataga     3660

tttatgtaat gctttatgtt taaaaacatt ccccaattat cttatttaat ttttgcaatt     3720

attctaattt tatatataga gaaagtgacc tattttttaa aaaaatcaca ctctaagttc     3780

tattgaacct aggacttgag cctccatttc tggcttctag tctggtgttc tgagtacttg     3840

atttcaggtc aataacggtc ccccctcact ccacactggc acgtttgtga gaagaaatga     3900

cattttgcta ggaagtgacc gagtctagga atgcttttat tcaagacacc aaattccaaa     3960

cttctaaatg ttggaatttt caaaaattgt gtttagattt tatgaaaaac tcttctactt     4020

tcatctattc tttccctaga ggcaaacatt tcttaaaatg tttcattttc attaaaaatg     4080

aaagccaaat ttatatgcca ccgattgcag gacacaagca cagttttaag agttgtatga     4140

acatggagag gacttttggt ttttatattt ctcgtattta atatgggtga acaccaactt     4200

ttatttggaa taataatttt cctcctaaac aaaaacacat tgagtttaag tctctgactc     4260

ttgcctttcc acctgctttc tcctgggccc gctttgcctg cttgaaggaa cagtgctgtt     4320

ctggagctgc tgttccaaca gacagggcct agctttcatt tgacacacag actacagcca     4380

gaagcccatg gagcagggat gtcacgtctt gaaaagccta ttagatgttt tacaaattta     4440

attttgcaga ttattttagt ctgtcatcca gaaaatgtgt cagcatgcat agtgctaaga     4500

aagcaagcca atttggaaac ttaggttagt gacaaaattg gccagagagt gggggtgatg     4560

atgaccaaga attacaagta gaatggcagc tggaatttaa ggagggacaa gaatcaatgg     4620

ataagcgtgg gtggaggaag atccaaacag aaaagtgcaa agttattccc catcttccaa     4680

gggttgaatt ctggaggaag aagacacatt cctagttccc cgtgaacttc ctttgactta     4740

ttgtccccac taaaacaaaa caaaaaactt ttaatgcctt ccacattaat tagattttct     4800

tgcagttttt ttatggcatt tttttaaaga tgccctaagt gttgaagaag agtttgcaaa     4860

tgcaacaaaa tatttaatta ccggttgtta aaactggttt agcacaattt atattttccc     4920

tctcttgcct ttcttatttg caataaaagg tattgagcca ttttttaaat gacatttttg     4980

ataaattatg tttgtactag ttgatgaagg agtttttttt aacctgttta tataattttg     5040

cagcagaagc caaatttttt gtatattaaa gcaccaaatt catgtacagc atgcatcacg     5100

gatcaataga ctgtacttat tttccaataa aattttcaaa ctttgtactg ttaaaaaaaa     5160

aaaaaaaaaa                                                            5170


<210>  6
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  7
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  7
atgaaagtgt tactcagact tatttgtttc atagctctac tgatttcttc tctggaggct       60

gataaatgca aggaacgtga agaaaaaata attttagtgt catctgcaaa tgaaattgat      120

gttcgtccct gtcctcttaa cccaaatgaa cacaaaggca ctataacttg gtataaagat      180

gacagcaaga cacctgtatc tacagaacaa gcctccagga ttcatcaaca caaagagaaa      240

ctttggtttg ttcctgctaa ggtggaggat tcaggacatt actattgcgt ggtaagaaat      300

tcatcttact gcctcagaat taaaataagt gcaaaatttg tggagaatga gcctaactta      360

tgttataatg cacaagccat atttaagcag aaactacccg ttgcaggaga cggaggactt      420

gtgtgccctt atatggagtt ttttaaaaat gaaaataatg agttacctaa attacagtgg      480

tataaggatt gcaaacctct acttcttgac aatatacact ttagtggagt caaagatagg      540

ctcatcgtga tgaatgtggc tgaaaagcat agagggaact atacttgtca tgcatcctac      600

acatacttgg gcaagcaata tcctattacc cgggtaatag aatttattac tctagaggaa      660

aacaaaccca caaggcctgt gattgtgagc ccagctaatg agacaatgga agtagacttg      720

ggatcccaga tacaattgat ctgtaatgtc accggccagt tgagtgacat tgcttactgg      780

aagtggaatg ggtcagtaat tgatgaagat gacccagtgc taggggaaga ctattacagt      840

gtggaaaatc ctgcaaacaa aagaaggagt accctcatca cagtgcttaa tatatcggaa      900

attgaaagta gattttataa acatccattt acctgttttg ccaagaatac acatggtata      960

gatgcagcat atatccagtt aatatatcca gtcactaatt tccagaagca catgattggt     1020

atatgtgtca cgttgacagt cataattgtg tgttctgttt tcatctataa aatcttcaag     1080

attgacattg tgctttggta cagggattcc tgctatgatt ttctcccaat aaaagtcttg     1140

cctgaggtct tggaaaaaca gtgtggatat aagctgttca tttatggaag ggatgactac     1200

gttggggaag acattgttga ggtcattaat gaaaacgtaa agaaaagcag aagactgatt     1260

atcattttag tcagagaaac atcaggcttc agctggctgg gtggttcatc tgaagagcaa     1320

atagccatgt ataatgctct tgttcaggat ggaattaaag ttgtcctgct tgagctggag     1380

aaaatccaag actatgagaa aatgccagaa tcgattaaat tcattaagca gaaacatggg     1440

gctatccgct ggtcagggga ctttacacag ggaccacagt ctgcaaagac aaggttctgg     1500

aagaatgtca ggtaccacat gccagtccag cgacggtcac cttcatctaa acaccagtta     1560

ctgtcaccag ccactaagga gaaactgcaa agagaggctc acgtgcctct cggg           1614


<210>  8
<211>  4990
<212>  DNA
<213>  Homo sapiens

<400>  8
attggcagct cttcacttgt atcttttcat atcaaaaatg ggaggtgaca cccagtttaa       60

ggaaaattcc aaggcatttg tctcgactaa tgtgaaagat gattacagtg gccagaggac      120

tgccaaggct ccttctcaag ctgcttgagt caatgagggt agacgcaccc tctgaagatg      180

gtgactccct cctgagaagc tggacccctt ggtaaaagac aaggccttct ccaagaagaa      240

tatgaaagtg ttactcagac ttatttgttt catagctcta ctgatttctt ctctggaggc      300

tgataaatgc aaggaacgtg aagaaaaaat aattttagtg tcatctgcaa atgaaattga      360

tgttcgtccc tgtcctctta acccaaatga acacaaaggc actataactt ggtataaaga      420

tgacagcaag acacctgtat ctacagaaca agcctccagg attcatcaac acaaagagaa      480

actttggttt gttcctgcta aggtggagga ttcaggacat tactattgcg tggtaagaaa      540

ttcatcttac tgcctcagaa ttaaaataag tgcaaaattt gtggagaatg agcctaactt      600

atgttataat gcacaagcca tatttaagca gaaactaccc gttgcaggag acggaggact      660

tgtgtgccct tatatggagt tttttaaaaa tgaaaataat gagttaccta aattacagtg      720

gtataaggat tgcaaacctc tacttcttga caatatacac tttagtggag tcaaagatag      780

gctcatcgtg atgaatgtgg ctgaaaagca tagagggaac tatacttgtc atgcatccta      840

cacatacttg ggcaagcaat atcctattac ccgggtaata gaatttatta ctctagagga      900

aaacaaaccc acaaggcctg tgattgtgag cccagctaat gagacaatgg aagtagactt      960

gggatcccag atacaattga tctgtaatgt caccggccag ttgagtgaca ttgcttactg     1020

gaagtggaat gggtcagtaa ttgatgaaga tgacccagtg ctaggggaag actattacag     1080

tgtggaaaat cctgcaaaca aaagaaggag taccctcatc acagtgctta atatatcgga     1140

aattgaaagt agattttata aacatccatt tacctgtttt gccaagaata cacatggtat     1200

agatgcagca tatatccagt taatatatcc agtcactaat ttccagaagc acatgattgg     1260

tatatgtgtc acgttgacag tcataattgt gtgttctgtt ttcatctata aaatcttcaa     1320

gattgacatt gtgctttggt acagggattc ctgctatgat tttctcccaa taaaagtctt     1380

gcctgaggtc ttggaaaaac agtgtggata taagctgttc atttatggaa gggatgacta     1440

cgttggggaa gacattgttg aggtcattaa tgaaaacgta aagaaaagca gaagactgat     1500

tatcatttta gtcagagaaa catcaggctt cagctggctg ggtggttcat ctgaagagca     1560

aatagccatg tataatgctc ttgttcagga tggaattaaa gttgtcctgc ttgagctgga     1620

gaaaatccaa gactatgaga aaatgccaga atcgattaaa ttcattaagc agaaacatgg     1680

ggctatccgc tggtcagggg actttacaca gggaccacag tctgcaaaga caaggttctg     1740

gaagaatgtc aggtaccaca tgccagtcca gcgacggtca ccttcatcta aacaccagtt     1800

actgtcacca gccactaagg agaaactgca aagagaggct cacgtgcctc tcgggtagca     1860

tggagaagtt gccaagagtt ctttaggtgc ctcctgtctt atggcgttgc aggccaggtt     1920

atgcctcatg ctgacttgca gagttcatgg aatgtaacta tatcatcctt tatccctgag     1980

gtcacctgga atcagattat taagggaata agccatgacg tcaatagcag cccagggcac     2040

ttcagagtag agggcttggg aagatctttt aaaaaggcag taggcccggt gtggtggctc     2100

acgcctataa tcccagcact ttgggaggct gaagtgggtg gatcaccaga ggtcaggagt     2160

tcgagaccag cccagccaac atggcaaaac cccatctcta ctaaaaatac aaaaatgagc     2220

taggcatggt ggcacacgcc tgtaatccca gctacacctg aggctgaggc aggagaattg     2280

cttgaaccgg ggagacggag gttgcagtga gccgagtttg ggccactgca ctctagcctg     2340

gcaacagagc aagactccgt ctcaaaaaaa gggcaataaa tgccctctct gaatgtttga     2400

actgccaaga aaaggcatgg agacagcgaa ctagaagaaa gggcaagaag gaaatagcca     2460

ccgtctacag atggcttagt taagtcatcc acagcccaag ggcggggcta tgccttgtct     2520

ggggaccctg tagagtcact gaccctggag cggctctcct gagaggtgct gcaggcaaag     2580

tgagactgac acctcactga ggaagggaga catattcttg gagaactttc catctgcttg     2640

tattttccat acacatcccc agccagaagt tagtgtccga agaccgaatt ttattttaca     2700

gagcttgaaa actcacttca atgaacaaag ggattctcca ggattccaaa gttttgaagt     2760

catcttagct ttccacagga gggagagaac ttaaaaaagc aacagtagca gggaattgat     2820

ccacttctta atgctttcct ccctggcatg accatcctgt cctttgttat tatcctgcat     2880

tttacgtctt tggaggaaca gctccctagt ggcttcctcc gtctgcaatg tcccttgcac     2940

agcccacaca tgaaccatcc ttcccatgat gccgctcttc tgtcatcccg ctcctgctga     3000

aacacctccc aggggctcca cctgttcagg agctgaagcc catgctttcc caccagcatg     3060

tcactcccag accacctccc tgccctgtcc tccagcttcc cctcgctgtc ctgctgtgtg     3120

aattcccagg ttggcctggt ggccatgtcg cctgccccca gcactcctct gtctctgctc     3180

ttgcctgcac ccttcctcct cctttgccta ggaggccttc tcgcattttc tctagctgat     3240

cagaatttta ccaaaattca gaacatcctc caattccaca gtctctggga gactttccct     3300

aagaggcgac ttcctctcca gccttctctc tctggtcagg cccactgcag agatggtggt     3360

gagcacatct gggaggctgg tctccctcca gctggaattg ctgctctctg agggagaggc     3420

tgtggtggct gtctctgtcc ctcactgcct tccaggagca atttgcacat gtaacataga     3480

tttatgtaat gctttatgtt taaaaacatt ccccaattat cttatttaat ttttgcaatt     3540

attctaattt tatatataga gaaagtgacc tattttttaa aaaaatcaca ctctaagttc     3600

tattgaacct aggacttgag cctccatttc tggcttctag tctggtgttc tgagtacttg     3660

atttcaggtc aataacggtc ccccctcact ccacactggc acgtttgtga gaagaaatga     3720

cattttgcta ggaagtgacc gagtctagga atgcttttat tcaagacacc aaattccaaa     3780

cttctaaatg ttggaatttt caaaaattgt gtttagattt tatgaaaaac tcttctactt     3840

tcatctattc tttccctaga ggcaaacatt tcttaaaatg tttcattttc attaaaaatg     3900

aaagccaaat ttatatgcca ccgattgcag gacacaagca cagttttaag agttgtatga     3960

acatggagag gacttttggt ttttatattt ctcgtattta atatgggtga acaccaactt     4020

ttatttggaa taataatttt cctcctaaac aaaaacacat tgagtttaag tctctgactc     4080

ttgcctttcc acctgctttc tcctgggccc gctttgcctg cttgaaggaa cagtgctgtt     4140

ctggagctgc tgttccaaca gacagggcct agctttcatt tgacacacag actacagcca     4200

gaagcccatg gagcagggat gtcacgtctt gaaaagccta ttagatgttt tacaaattta     4260

attttgcaga ttattttagt ctgtcatcca gaaaatgtgt cagcatgcat agtgctaaga     4320

aagcaagcca atttggaaac ttaggttagt gacaaaattg gccagagagt gggggtgatg     4380

atgaccaaga attacaagta gaatggcagc tggaatttaa ggagggacaa gaatcaatgg     4440

ataagcgtgg gtggaggaag atccaaacag aaaagtgcaa agttattccc catcttccaa     4500

gggttgaatt ctggaggaag aagacacatt cctagttccc cgtgaacttc ctttgactta     4560

ttgtccccac taaaacaaaa caaaaaactt ttaatgcctt ccacattaat tagattttct     4620

tgcagttttt ttatggcatt tttttaaaga tgccctaagt gttgaagaag agtttgcaaa     4680

tgcaacaaaa tatttaatta ccggttgtta aaactggttt agcacaattt atattttccc     4740

tctcttgcct ttcttatttg caataaaagg tattgagcca ttttttaaat gacatttttg     4800

ataaattatg tttgtactag ttgatgaagg agtttttttt aacctgttta tataattttg     4860

cagcagaagc caaatttttt gtatattaaa gcaccaaatt catgtacagc atgcatcacg     4920

gatcaataga ctgtacttat tttccaataa aattttcaaa ctttgtactg ttaaaaaaaa     4980

aaaaaaaaaa                                                            4990


<210>  9
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Val Leu Pro Glu Val Leu 
    370                 375                 380                 


Glu Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr 
385                 390                 395                 400 


Val Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser 
                405                 410                 415     


Arg Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp 
            420                 425                 430         


Leu Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val 
        435                 440                 445             


Gln Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp 
    450                 455                 460                 


Tyr Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly 
465                 470                 475                 480 


Ala Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys 
                485                 490                 495     


Thr Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg 
            500                 505                 510         


Ser Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys 
        515                 520                 525             


Leu Gln Arg Glu Ala His Val Pro Leu Gly 
    530                 535             


<210>  10
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  11
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


<210>  12
<211>  1710
<212>  DNA
<213>  Homo sapiens

<400>  12
atgacacttc tgtggtgtgt agtgagtctc tacttttatg gaatcctgca aagtgatgcc       60

tcagaacgct gcgatgactg gggactagac accatgaggc aaatccaagt gtttgaagat      120

gagccagctc gcatcaagtg cccactcttt gaacacttct tgaaattcaa ctacagcaca      180

gcccattcag ctggccttac tctgatctgg tattggacta ggcaggaccg ggaccttgag      240

gagccaatta acttccgcct ccccgagaac cgcattagta aggagaaaga tgtgctgtgg      300

ttccggccca ctctcctcaa tgacactggc aactatacct gcatgttaag gaacactaca      360

tattgcagca aagttgcatt tcccttggaa gttgttcaaa aagacagctg tttcaattcc      420

cccatgaaac tcccagtgca taaactgtat atagaatatg gcattcagag gatcacttgt      480

ccaaatgtag atggatattt tccttccagt gtcaaaccga ctatcacttg gtatatgggc      540

tgttataaaa tacagaattt taataatgta atacccgaag gtatgaactt gagtttcctc      600

attgccttaa tttcaaataa tggaaattac acatgtgttg ttacatatcc agaaaatgga      660

cgtacgtttc atctcaccag gactctgact gtaaaggtag taggctctcc aaaaaatgca      720

gtgccccctg tgatccattc acctaatgat catgtggtct atgagaaaga accaggagag      780

gagctactca ttccctgtac ggtctatttt agttttctga tggattctcg caatgaggtt      840

tggtggacca ttgatggaaa aaaacctgat gacatcacta ttgatgtcac cattaacgaa      900

agtataagtc atagtagaac agaagatgaa acaagaactc agattttgag catcaagaaa      960

gttacctctg aggatctcaa gcgcagctat gtctgtcatg ctagaagtgc caaaggcgaa     1020

gttgccaaag cagccaaggt gaagcagaaa gtgccagctc caagatacac agtggaactg     1080

gcttgtggtt ttggagccac agtcctgcta gtggtgattc tcattgttgt ttaccatgtt     1140

tactggctag agatggtcct attttaccgg gctcattttg gaacagatga aaccatttta     1200

gatggaaaag agtatgatat ttatgtatcc tatgcaagga atgcggaaga agaagaattt     1260

gtattactga ccctccgtgg agttttggag aatgaatttg gatacaagct gtgcatcttt     1320

gaccgagaca gtctgcctgg gggaattgtc acagatgaga ctttgagctt cattcagaaa     1380

agcagacgcc tcctggttgt tctaagcccc aactacgtgc tccagggaac ccaagccctc     1440

ctggagctca aggctggcct agaaaatatg gcctctcggg gcaacatcaa cgtcatttta     1500

gtacagtaca aagctgtgaa ggaaacgaag gtgaaagagc tgaagagggc taagacggtg     1560

ctcacggtca ttaaatggaa aggggaaaaa tccaagtatc cacagggcag gttctggaag     1620

cagctgcagg tggccatgcc agtgaagaaa agtcccaggc ggtctagcag tgatgagcag     1680

ggcctctcgt attcatcttt gaaaaatgta                                      1710


<210>  13
<211>  4801
<212>  DNA
<213>  Homo sapiens

<400>  13
aaagggggaa aagaaagtgc ggcggaaagt aagaggctca ctggggaaga ctgccgggat       60

ccaggtctcc ggggtccgct ttggccagag gcgcggaagg aagcagtgcc cggcgacact      120

gcacccatcc cggctgcttt tgctgcgccc tctcagcttc ccaagaaagg catcgtcatg      180

tgatcatcac ctaagaacta gaacatcagc aggccctaga agcctcactc ttgcccctcc      240

ctttaatatc tcaaaggatg acacttctgt ggtgtgtagt gagtctctac ttttatggaa      300

tcctgcaaag tgatgcctca gaacgctgcg atgactgggg actagacacc atgaggcaaa      360

tccaagtgtt tgaagatgag ccagctcgca tcaagtgccc actctttgaa cacttcttga      420

aattcaacta cagcacagcc cattcagctg gccttactct gatctggtat tggactaggc      480

aggaccggga ccttgaggag ccaattaact tccgcctccc cgagaaccgc attagtaagg      540

agaaagatgt gctgtggttc cggcccactc tcctcaatga cactggcaac tatacctgca      600

tgttaaggaa cactacatat tgcagcaaag ttgcatttcc cttggaagtt gttcaaaaag      660

acagctgttt caattccccc atgaaactcc cagtgcataa actgtatata gaatatggca      720

ttcagaggat cacttgtcca aatgtagatg gatattttcc ttccagtgtc aaaccgacta      780

tcacttggta tatgggctgt tataaaatac agaattttaa taatgtaata cccgaaggta      840

tgaacttgag tttcctcatt gccttaattt caaataatgg aaattacaca tgtgttgtta      900

catatccaga aaatggacgt acgtttcatc tcaccaggac tctgactgta aaggtagtag      960

gctctccaaa aaatgcagtg ccccctgtga tccattcacc taatgatcat gtggtctatg     1020

agaaagaacc aggagaggag ctactcattc cctgtacggt ctattttagt tttctgatgg     1080

attctcgcaa tgaggtttgg tggaccattg atggaaaaaa acctgatgac atcactattg     1140

atgtcaccat taacgaaagt ataagtcata gtagaacaga agatgaaaca agaactcaga     1200

ttttgagcat caagaaagtt acctctgagg atctcaagcg cagctatgtc tgtcatgcta     1260

gaagtgccaa aggcgaagtt gccaaagcag ccaaggtgaa gcagaaagtg ccagctccaa     1320

gatacacagt ggaactggct tgtggttttg gagccacagt cctgctagtg gtgattctca     1380

ttgttgttta ccatgtttac tggctagaga tggtcctatt ttaccgggct cattttggaa     1440

cagatgaaac cattttagat ggaaaagagt atgatattta tgtatcctat gcaaggaatg     1500

cggaagaaga agaatttgta ttactgaccc tccgtggagt tttggagaat gaatttggat     1560

acaagctgtg catctttgac cgagacagtc tgcctggggg aattgtcaca gatgagactt     1620

tgagcttcat tcagaaaagc agacgcctcc tggttgttct aagccccaac tacgtgctcc     1680

agggaaccca agccctcctg gagctcaagg ctggcctaga aaatatggcc tctcggggca     1740

acatcaacgt cattttagta cagtacaaag ctgtgaagga aacgaaggtg aaagagctga     1800

agagggctaa gacggtgctc acggtcatta aatggaaagg ggaaaaatcc aagtatccac     1860

agggcaggtt ctggaagcag ctgcaggtgg ccatgccagt gaagaaaagt cccaggcggt     1920

ctagcagtga tgagcagggc ctctcgtatt catctttgaa aaatgtatga aaggaataat     1980

gaaaagggta aaaagaacaa ggggtgctcc aggaagaaag agtcccccca gtcttcattc     2040

gcagtttatg gtttcatagg caaaaataat ggtctaagcc tcccaatagg gataaattta     2100

gggtgactgt gtggctgact attctgcttc ctcaggcaac actaaagttt agaaagatat     2160

catcaacgtt ctgtcaccag tctctgatgc cactatgttc tttgcaggca aagacttgtt     2220

caatgcgaat ttccccttct acattgtcta tccctgtttt tatatgtctc cattcttttt     2280

aaaatcttaa catatggagc agcctttcct atgaatttaa atatgccttt aaaataagtc     2340

actgttgaca gggtcatgag tttccgagta tagttttctt tttatcttat ttttactcgt     2400

ccgttgaaaa gataatcaag gcctacattt tagctgagga taatgaactt ttttcctcat     2460

tcggctgtat aatacataac cacagcaaga ctgacatcca cttaggatga tacaaagcag     2520

tgtaactgaa aatgtttctt ttaattgatt taaaggactt gtcttctata ccacccttgt     2580

cctcatctca ggtaatttat gaaatctatg taaacttgaa aaatatttct taatttttgt     2640

ttttgctcca gtcaattcct gattatccac aggtcaaccc acattttttc attccttctc     2700

cctatctgct tatatcgcat tgctcattta gagtttgcag gaggctccat actaggttca     2760

gtctgaaaga aatctcctaa tggtgctata gagagggagg taacagaaag actcttttag     2820

ggcatttttc tgactcatga aaagagcaca gaaaaggatg tttggcaatt tgtcttttaa     2880

gtcttaacct tgctaatgtg aatactggga aagtgatttt ttctcactcg tttttgttgc     2940

tccattgtaa agggcggagg tcagtcttag tggccttgag agttgctttt ggcattaata     3000

ttctaagaga attaactgta tttcctgtca cctattcact agtgcaggaa atatacttgc     3060

tccaaataag tcagtatgag aagtcactgt caatgaaagt tgttttgttt gttttcagta     3120

atattttgct gtttttaaga cttggaaaac taagtgcaga gtttacagag tggtaaatat     3180

ctatgttaca tgtagattat acatatatat acacacgtgt atatgagata tatatcttat     3240

atctccacaa acacaaatta tatatataca tatccacaca catacattac atatatctgt     3300

gtatataaat ccacatgcac atgaaatata tatatatata taatttgtgt gtgtgtatgt     3360

gtatgtatat gactttaaat agctatgggt acaatattaa aaaccactgg aactcttgtc     3420

cagtttttaa attatgtttt tactggaatg tttttgtgtc agtgttttct gtacatatta     3480

tttgttaatt cacagctcac agagtgatag ttgtcatagt tcttgccttc cctaagttta     3540

tataaataac ttaagtattg ctacagttta tctaggttgc agtggcatct gctgtgcaca     3600

gagcttccat ggtcactgct aagcagtagc cagccatcgg gcattaattg atttcctact     3660

atattcccag cagacacatt tagaaactaa gctatgttaa cctcagtgct caactatttg     3720

aactgttgag tgataaagga aacaaatata actgtaaatg aatcttggta tcctgtgaaa     3780

cagaataatt cgtaatttaa gaaagccctt atcccggtaa catgaatgtt gatgaacaaa     3840

tgtaaaatta tatcctatat ttaagtaccc ataataaatc atttccctct ataagtgtta     3900

ttgattattt taaattgaaa aaagtttcac ttggatgaaa aaagtagaaa agtaggtcat     3960

tcttggatct actttttttt agccttatta atatttttcc ctattagaaa ccacaattac     4020

tccctctatt aacccttcac ttactagacc agaaaagaac ttattccaga taagctttga     4080

atatcaattc ttacataaac tttaggcaaa cagggaatag tctagtcacc aaaggaccat     4140

tctcttgcca atgctgcatt ccttttgcac ttttggattc catatttatc ccaaatgctg     4200

ttgggcaccc ctagaaatac cttgatgttt tttctattta tatgcctgcc tttggtactt     4260

aattttacaa atgctgtaat ataaagcata tcaagtttat gtgatacgta tcattgcaag     4320

agaatttgtt tcaagatttt tttttaatgt tccagaagat ggccaataga gaacattcaa     4380

gggaaatggg gaaacataat ttagagaaca agaacaaacc atgtctcaaa tttttttaaa     4440

aaaaattaat ggttttaaat atatgctata gggacgttcc atgcccaggt taacaaagaa     4500

ctgtgatata tagagtgtct aattacaaaa tcatatacga tttatttaat tctcttctgt     4560

attgtaactt agatgattcc caaggactct aataaaaaat cacttcattg tatttggaaa     4620

caaaaacatc attcattaat tacttatttt ctttccatag gttttaatat tttgagagtg     4680

tcttttttat ttcattcatg aacttttgta tttttcattt ttcatttgat ttgtaaattt     4740

acttatgtta aaaataaacc atttattttc agctttgaat tttaaaaaaa aaaaaaaaaa     4800

a                                                                     4801


<210>  14
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  15
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  15
atgacacttc tgtggtgtgt agtgagtctc tacttttatg gaatcctgca aagtgatgcc       60

tcagaacgct gcgatgactg gggactagac accatgaggc aaatccaagt gtttgaagat      120

gagccagctc gcatcaagtg cccactcttt gaacacttct tgaaattcaa ctacagcaca      180

gcccattcag ctggccttac tctgatctgg tattggacta ggcaggaccg ggaccttgag      240

gagccaatta acttccgcct ccccgagaac cgcattagta aggagaaaga tgtgctgtgg      300

ttccggccca ctctcctcaa tgacactggc aactatacct gcatgttaag gaacactaca      360

tattgcagca aagttgcatt tcccttggaa gttgttcaaa aagacagctg tttcaattcc      420

cccatgaaac tcccagtgca taaactgtat atagaatatg gcattcagag gatcacttgt      480

ccaaatgtag atggatattt tccttccagt gtcaaaccga ctatcacttg gtatatgggc      540

tgttataaaa tacagaattt taataatgta atacccgaag gtatgaactt gagtttcctc      600

attgccttaa tttcaaataa tggaaattac acatgtgttg ttacatatcc agaaaatgga      660

cgtacgtttc atctcaccag gactctgact gtaaaggtag taggctctcc aaaaaatgca      720

gtgccccctg tgatccattc acctaatgat catgtggtct atgagaaaga accaggagag      780

gagctactca ttccctgtac ggtctatttt agttttctga tggattctcg caatgaggtt      840

tggtggacca ttgatggaaa aaaacctgat gacatcacta ttgatgtcac cattaacgaa      900

agtataagtc atagtagaac agaagatgaa acaagaactc agattttgag catcaagaaa      960

gttacctctg aggatctcaa gcgcagctat gtctgtcatg ctagaagtgc caaaggcgaa     1020

gttgccaaag cagccaaggt gaagcagaaa ggtaatagat gcggtcag                  1068


<210>  16
<211>  2114
<212>  DNA
<213>  Homo sapiens

<400>  16
aaagggggaa aagaaagtgc ggcggaaagt aagaggctca ctggggaaga ctgccgggat       60

ccaggtctcc ggggtccgct ttggccagag gcgcggaagg aagcagtgcc cggcgacact      120

gcacccatcc cggctgcttt tgctgcgccc tctcagcttc ccaagaaagg catcgtcatg      180

tgatcatcac ctaagaacta gaacatcagc aggccctaga agcctcactc ttgcccctcc      240

ctttaatatc tcaaaggatg acacttctgt ggtgtgtagt gagtctctac ttttatggaa      300

tcctgcaaag tgatgcctca gaacgctgcg atgactgggg actagacacc atgaggcaaa      360

tccaagtgtt tgaagatgag ccagctcgca tcaagtgccc actctttgaa cacttcttga      420

aattcaacta cagcacagcc cattcagctg gccttactct gatctggtat tggactaggc      480

aggaccggga ccttgaggag ccaattaact tccgcctccc cgagaaccgc attagtaagg      540

agaaagatgt gctgtggttc cggcccactc tcctcaatga cactggcaac tatacctgca      600

tgttaaggaa cactacatat tgcagcaaag ttgcatttcc cttggaagtt gttcaaaaag      660

acagctgttt caattccccc atgaaactcc cagtgcataa actgtatata gaatatggca      720

ttcagaggat cacttgtcca aatgtagatg gatattttcc ttccagtgtc aaaccgacta      780

tcacttggta tatgggctgt tataaaatac agaattttaa taatgtaata cccgaaggta      840

tgaacttgag tttcctcatt gccttaattt caaataatgg aaattacaca tgtgttgtta      900

catatccaga aaatggacgt acgtttcatc tcaccaggac tctgactgta aaggtagtag      960

gctctccaaa aaatgcagtg ccccctgtga tccattcacc taatgatcat gtggtctatg     1020

agaaagaacc aggagaggag ctactcattc cctgtacggt ctattttagt tttctgatgg     1080

attctcgcaa tgaggtttgg tggaccattg atggaaaaaa acctgatgac atcactattg     1140

atgtcaccat taacgaaagt ataagtcata gtagaacaga agatgaaaca agaactcaga     1200

ttttgagcat caagaaagtt acctctgagg atctcaagcg cagctatgtc tgtcatgcta     1260

gaagtgccaa aggcgaagtt gccaaagcag ccaaggtgaa gcagaaaggt aatagatgcg     1320

gtcagtgatg aatctctcag ctccaaatta acattgtggt gaataaggac aaaaggagag     1380

attgagaaca agagagctcc agcacctagc ccgacggcat ctaacccata gtaatgaatc     1440

aaacttaaat gaaaaatatg aaagttttca tctatgtaag atactcaaaa tattgtttct     1500

gatattgtta gtaccgtaat gcccaaatgt agctaaaaaa atcgacgtga gtacagtgag     1560

acacaatttt gtgtctgtac aattatgaaa aattaaaaac aaagaaaata ttcaaagcta     1620

ccaaagatag aaaaaactgg tagagccaca tattgttggt gaattattaa gaccctttta     1680

aaaatcattc atggtagact tcaagagtca taaaaaagat tgcatcatct gacctaagac     1740

tttcggaatt tttcctgaac aaataacaga aagggaatta tatacctttt aatattatta     1800

gaagcattat ctgtagttgt aaaacattat taatagcagc catccaattg tatgcaacta     1860

attaaggtat tgaatgttta ttttccaaaa atgcataatt ataatattat tttaaacact     1920

atgtatcaat atttaagcag gtttataata taccagcagc cacaattgct aaaatgaaaa     1980

tcatttaaat tatgatttta aatggtataa acatgatttc tatgttgata gtactatatt     2040

attctacaat aaatggaaat tataaagcct tcttgtcaga agtgctgctc ctaaaaaaaa     2100

aaaaaaaaaa aaaa                                                       2114


<210>  17
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         


Arg Cys Gly Gln 
        355     


<210>  18
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  19
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  20
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  21
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


