                         SEQUENCE LISTING

<110>  Genmab A/S
 
<120>  Antibodies Binding AXL

<130>  P/0083-WO

<160>  147   

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  homo sapiens

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Thr Ser Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ile Trp Ile Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  3
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ile Ser Gly Ala Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Arg Gly Tyr Ser Gly Tyr Val Tyr Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ile Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Arg Gly Tyr Ser Gly Tyr Val Tyr Asp Ala Phe Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  7
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  7

Glu Val Gln Leu Leu Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ile Gly Gly Gly Asn Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Gly Phe Ile Met Val Arg Gly Pro Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  8

Glu Val Gln Leu Leu Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ile Gly Gly Gly Asn Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Gly Phe Ile Leu Val Arg Gly Pro Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  10
<211>  125
<212>  PRT
<213>  homo sapiens

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Val Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  12
<211>  125
<212>  PRT
<213>  homo sapiens

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Val Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  13
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  14
<211>  125
<212>  PRT
<213>  homo sapiens

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Val Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  15
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  15

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  16
<211>  117
<212>  PRT
<213>  homo sapiens

<400>  16

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Gln Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ser Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Gly Asn Trp Asp His Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  117
<212>  PRT
<213>  homo sapiens

<400>  17

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Gln Gln Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ser Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Gly Asn Trp Asp His Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Thr Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  19
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  19

Gln Val Pro Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


His Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Phe Ile Thr Met Ile Arg Gly Thr Ile Ile Thr His Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  20
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Val Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Val Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  26
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  28
<211>  106
<212>  PRT
<213>  homo sapiens

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  29
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  30
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  31

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Asp Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Ala Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Phe Ile Thr Met Ile Arg Gly Ala Ile Ile Thr His Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120             


<210>  32
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  32

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Asp Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Ala Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Phe Ile Thr Leu Ile Arg Gly Ala Ile Ile Thr His Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120             


<210>  33
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asp Asn Lys Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Lys Leu Gly Ile Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  35

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  36
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  36

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  37

Thr Ser Gly Ser Gly Ala Ser Thr 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  38

Ala Lys Ile Trp Ile Ala Phe Asp Ile 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  39

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  40

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  41
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  41

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  42

Ile Ser Ile Ser Gly Ala Ser Thr 
1               5               


<210>  43
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  43

Arg Gly Tyr Ser Gly Tyr Val Tyr Asp Ala Phe Asp Ile 
1               5                   10              


<210>  44
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  44

Gln Gly Ile Ser Asn Trp 
1               5       


<210>  45
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  45

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  46
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  46

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  47

Ile Ser Ile Ser Gly Gly Ser Thr 
1               5               


<210>  48
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  48

Arg Gly Tyr Ser Gly Tyr Val Tyr Asp Ala Phe Asp Phe 
1               5                   10              


<210>  49
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  49

Gln Gly Ile Ser Asn Trp 
1               5       


<210>  50
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  50

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  51

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  52

Ile Ser Ile Gly Gly Gly Asn Ala 
1               5               


<210>  53
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  53

Ala Lys Pro Gly Phe Ile Met Val Arg Gly Pro Leu Asp Tyr 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  54

Ala Lys Pro Gly Phe Ile Leu Val Arg Gly Pro Leu Asp Tyr 
1               5                   10                  


<210>  55
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  55

Gln Ser Val Ser Asn Ser Tyr 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  56

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  57
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  57

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  58

Ile Ser Val Ser Gly Gly Ser Thr 
1               5               


<210>  59
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  59

Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  60
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  60

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  61
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  61

Gln Gln Tyr Gly Arg Ser Phe Thr 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  62

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  63

Ile Ser Val Ser Gly Gly Ser Thr 
1               5               


<210>  64
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  64

Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  65
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  65

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  66
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  66

Gln Gln Tyr Gly Arg Ser Phe Thr 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  67

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  68

Ile Ser Val Ser Gly Gly Ser Thr 
1               5               


<210>  69
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  69

Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  70
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  70

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  71
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  71

Gln Gln Tyr Gly Arg Ser Phe Thr 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  72

Gly Gly Ser Phe Ser Gly Tyr Tyr 
1               5               


<210>  73
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  73

Ile Asn Gln Ser Gly 
1               5   


<210>  74
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  74

Ile Gln Gln Ser Gly Ser Thr 
1               5           


<210>  75
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  75

Ala Ser Gly Asn Trp Asp His Phe Phe Asp Tyr 
1               5                   10      


<210>  76
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  76

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  77
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  77

Gln Gln Ala Lys Ser Phe Pro Trp Thr 
1               5                   


<210>  78
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  78

Gly Gly Ser Phe Ser Gly Tyr His 
1               5               


<210>  79
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  79

Ile Ser His Ser Gly Arg Thr 
1               5           


<210>  80
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  80

Ala Ser Phe Ile Thr Met Ile Arg Gly Thr Ile Ile Thr His Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  81
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  81

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  82
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  82

Gln Gln Tyr His Ser Tyr Pro Tyr Thr 
1               5                   


<210>  83
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  83

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  84

Ile Ile Pro Ile Phe Gly Ile Ala 
1               5               


<210>  85
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  85

Ala Arg Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  86
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  86

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  87
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  87

Gln Gln Tyr Gly Ser Ser Tyr Thr 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  88

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  89

Ile Ile Pro Ile Phe Gly Ile Ala 
1               5               


<210>  90
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  90

Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  91
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  91

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  92
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  92

Gln Gln Tyr Gly Ser Ser Tyr Thr 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  93

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  94

Ile Ile Pro Ile Phe Gly Ile Val 
1               5               


<210>  95
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  95

Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  96
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  96

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  97
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  97

Gln Gln Tyr Gly Ser Ser Tyr Thr 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  98

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  99

Ile Ile Pro Ile Phe Gly Ile Val 
1               5               


<210>  100
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  100

Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  101
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  101

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  102
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  102

Gln Gln Arg Ser Asn Trp Leu Thr 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  103

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  104

Ile Ile Pro Ile Phe Gly Ile Ala 
1               5               


<210>  105
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  105

Ala Arg Arg Gly Asn Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
1               5                   10                  15      


Ile Ser 
        


<210>  106
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  106

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  107
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  107

Gln Gln Tyr Gly Ser Ser Tyr Thr 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  108

Gly Gly Ser Phe Ser Gly Tyr Tyr 
1               5               


<210>  109
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  109

Ile Ser His Ser Gly Arg Thr 
1               5           


<210>  110
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  110

Ala Arg Phe Ile Thr Met Ile Arg Gly Ala Ile Ile Thr His Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  111
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  111

Ala Arg Phe Ile Thr Leu Ile Arg Gly Ala Ile Ile Thr His Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  112
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  112

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  113
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  113

Gln Gln Tyr His Ser Tyr Pro Tyr Thr 
1               5                   


<210>  114
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  114

Gly Phe Ser Phe Ser Thr Tyr Ala 
1               5               


<210>  115
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  115

Ile Ser Tyr Asp Gly Asp Asn Lys 
1               5               


<210>  116
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  116

Ala Arg Gly Arg Lys Leu Gly Ile Asp Ala Phe Asp Ile 
1               5                   10              


<210>  117
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  117

Gln Gly Ile Ser Ser Ala 
1               5       


<210>  118
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  118

Gln Gln Phe Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  119
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is A or G

<400>  119

Ile Ser Ile Ser Gly Xaa Ser Thr 
1               5               


<210>  120
<211>  13
<212>  PRT
<213>  homo sapiens


<220>
<221>  Misc
<222>  (13)..(13)
<223>  Wherein X is I of F

<400>  120

Arg Gly Tyr Ser Gly Tyr Val Tyr Asp Ala Phe Asp Xaa 
1               5                   10              


<210>  121
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X is I or F

<400>  121

Gly Gly Ser Phe Ser Gly Tyr Xaa 
1               5               


<210>  122
<211>  17
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein X is S or R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X is T or A

<400>  122

Ala Xaa Phe Ile Thr Met Ile Arg Gly Xaa Ile Ile Thr His Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  123
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is S or N

<400>  123

Gly Phe Thr Phe Ser Xaa Tyr Ala 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  124

Ile Ser Val Ser Gly Gly Ser Thr 
1               5               


<210>  125
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  125

Ala Lys Glu Gly Tyr Ile Trp Phe Gly Glu Ser Leu Ser Tyr Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  126
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X is A or V

<400>  126

Ile Ile Pro Ile Phe Gly Ile Xaa 
1               5               


<210>  127
<211>  17
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Wherein X is D or N

<400>  127

Ala Arg Arg Gly Xaa Tyr Tyr Gly Ser Gly Ser Pro Asp Val Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  128
<211>  7
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X is S or deleted

<400>  128

Gln Ser Val Xaa Ser Ser Tyr 
1               5           


<210>  129
<211>  8
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein X is R or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X is Sor G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X is Sor G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Wherein X is N or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is W or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is W or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein X is L or Y

<400>  129

Gln Gln Xaa Xaa Xaa Xaa Xaa Thr 
1               5               


<210>  130
<211>  894
<212>  PRT
<213>  homo sapiens

<400>  130

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  131
<211>  904
<212>  PRT
<213>  Mus Musculus

<400>  131

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Tyr Pro Tyr Asp Val Pro Asp 
            20                  25                  30          


Tyr Ala Ala His Lys Asp Thr Gln Thr Glu Ala Gly Ser Pro Phe Val 
        35                  40                  45              


Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu 
    50                  55                  60                  


Arg Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Val Trp Leu 
65                  70                  75                  80  


Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Asn Thr Gln Thr Gln Val 
                85                  90                  95      


Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp Lys Val Val Ser Gln Leu 
            100                 105                 110         


Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala Gly Glu Tyr Gln Cys Met 
        115                 120                 125             


Val His Leu Glu Gly Arg Thr Phe Val Ser Gln Pro Gly Phe Val Gly 
    130                 135                 140                 


Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Lys Ala Val 
145                 150                 155                 160 


Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro 
                165                 170                 175     


Glu Pro Val Thr Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Pro 
            180                 185                 190         


Val Thr Gly His Ser Ser Gln His Ser Leu Gln Thr Pro Gly Leu Asn 
        195                 200                 205             


Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr 
    210                 215                 220                 


Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro His His 
225                 230                 235                 240 


Leu His Val Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr 
                245                 250                 255     


Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Asn Leu Gln Ala 
            260                 265                 270         


Val Leu Ser Asp Asp Gly Val Gly Ile Trp Leu Gly Lys Ser Asp Pro 
        275                 280                 285             


Pro Glu Asp Pro Leu Thr Leu Gln Val Ser Val Pro Pro His Gln Leu 
    290                 295                 300                 


Arg Leu Glu Lys Leu Leu Pro His Thr Pro Tyr His Ile Arg Ile Ser 
305                 310                 315                 320 


Cys Ser Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val 
                325                 330                 335     


Glu Thr Thr Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala 
            340                 345                 350         


Met Arg Asn Gly Ser Gln Val Leu Val Arg Trp Gln Glu Pro Arg Val 
        355                 360                 365             


Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln 
    370                 375                 380                 


Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Thr Arg Glu Val Thr 
385                 390                 395                 400 


Leu Glu Leu Arg Gly Asp Arg Pro Val Ala Asn Leu Thr Val Ser Val 
                405                 410                 415     


Thr Ala Tyr Thr Ser Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro 
            420                 425                 430         


Leu Glu Pro Trp Arg Pro Gly Gln Gly Gln Pro Leu His His Leu Val 
        435                 440                 445             


Ser Glu Pro Pro Pro Arg Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu 
    450                 455                 460                 


Leu Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe 
465                 470                 475                 480 


Leu Val His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu 
                485                 490                 495     


Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys 
            500                 505                 510         


Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile 
        515                 520                 525             


Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His 
    530                 535                 540                 


Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val 
545                 550                 555                 560 


Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val 
                565                 570                 575     


Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe 
            580                 585                 590         


Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met 
        595                 600                 605             


Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro 
    610                 615                 620                 


Ala Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser 
625                 630                 635                 640 


Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr 
                645                 650                 655     


Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr 
            660                 665                 670         


Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
        675                 680                 685             


Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser 
    690                 695                 700                 


Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys 
705                 710                 715                 720 


Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr 
                725                 730                 735     


Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile 
            740                 745                 750         


Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile 
        755                 760                 765             


Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys 
    770                 775                 780                 


Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro 
785                 790                 795                 800 


Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr 
                805                 810                 815     


Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val 
            820                 825                 830         


Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly 
        835                 840                 845             


Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys 
    850                 855                 860                 


Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro 
865                 870                 875                 880 


Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala 
                885                 890                 895     


Ala Pro Gly Gln Glu Asp Gly Ala 
            900                 


<210>  132
<211>  894
<212>  PRT
<213>  homo sapiens

<400>  132

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Lys Ala Val Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Thr Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Pro Val Thr Gly His Ser Ser Gln His Ser Leu 
            180                 185                 190         


Gln Thr Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  133
<211>  894
<212>  PRT
<213>  homo sapiens

<400>  133

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Lys Ala Val Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Thr Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Pro Val Thr Gly His Ser Ser Gln His Ser Leu 
            180                 185                 190         


Gln Thr Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  134
<211>  894
<212>  PRT
<213>  homo sapiens

<400>  134

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Arg Pro His His Leu His Val Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Asn Leu Gln Ala Val Leu Ser Asp Asp Gly Val Gly Ile Trp 
            260                 265                 270         


Leu Gly Lys Ser Asp Pro Pro Glu Asp Pro Leu Thr Leu Gln Val Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Glu Lys Leu Leu Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Ile Ser Cys Ser Ser Ser Gln Gly Pro Ser Pro Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Thr Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  135
<211>  894
<212>  PRT
<213>  homo sapiens

<400>  135

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Val Ser Ala Met Arg Asn Gly Ser Gln Val Leu Val Arg 
            340                 345                 350         


Trp Gln Glu Pro Arg Val Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Arg Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Thr Arg Glu Val Thr Leu Glu Leu Arg Gly Asp Arg Pro Val Ala 
385                 390                 395                 400 


Asn Leu Thr Val Ser Val Thr Ala Tyr Thr Ser Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Pro Trp Arg Pro Gly Gln Gly Gln 
            420                 425                 430         


Pro Leu His His Leu Val Ser Glu Pro Pro Pro Arg Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  136
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  136

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly His Thr Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Tyr Asp Ile Leu Thr Gly Tyr Tyr Asn Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  137
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  137

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  138

Ile Ser Gly Ser Gly Gly His Thr 
1               5               


<210>  139
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  139

Ala Lys Asp Arg Tyr Asp Ile Leu Thr Gly Tyr Tyr Asn Leu Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  140
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Glu Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Val Glu Ile Lys 
            100                 105         


<210>  141
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  141

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  142
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  142

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  143
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  143

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Gly Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Val Gln Asn Leu 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ile Ser Met Leu Arg Gly Ile Ile Ile Arg Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  144
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  144

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Trp Pro Arg 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  145
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  145

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Val Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr Ser Ser Ser Trp Tyr Ala Glu Tyr Phe Gln 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  146
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  146

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Phe Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  147
<211>  893
<212>  PRT
<213>  Macaca fascicularis

<400>  147

Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys Leu 
1               5                   10                  15      


Ala Leu Cys Gly Trp Val Cys Met Ala Pro Arg Gly Thr Gln Ala Glu 
            20                  25                  30          


Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly 
        35                  40                  45              


Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro Pro 
    50                  55                  60                  


Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser 
65                  70                  75                  80  


Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile 
                85                  90                  95      


Val Val Ser Gln Leu Arg Ile Ala Ser Leu Gln Leu Ser Asp Ala Gly 
            100                 105                 110         


Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Asn Phe Val Ser Gln 
        115                 120                 125             


Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro 
    130                 135                 140                 


Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln 
145                 150                 155                 160 


Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp Ala 
                165                 170                 175     


Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Asn Leu His 
            180                 185                 190         


Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn 
        195                 200                 205             


Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro 
    210                 215                 220                 


Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu Leu 
225                 230                 235                 240 


Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His 
                245                 250                 255     


Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln Ala 
            260                 265                 270         


Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Leu Gln Ala Ser Val 
        275                 280                 285             


Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro Tyr 
    290                 295                 300                 


His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr 
305                 310                 315                 320 


His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro Pro 
                325                 330                 335     


Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His Trp 
            340                 345                 350         


Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu 
        355                 360                 365             


Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu 
    370                 375                 380                 


Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser Asn 
385                 390                 395                 400 


Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro Trp 
                405                 410                 415     


Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln Pro 
            420                 425                 430         


Val His Gln Leu Val Lys Glu Thr Ser Ala Pro Ala Phe Ser Trp Pro 
        435                 440                 445             


Trp Trp Tyr Ile Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val Leu 
    450                 455                 460                 


Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg Tyr 
465                 470                 475                 480 


Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg 
                485                 490                 495     


Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu 
            500                 505                 510         


Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val 
        515                 520                 525             


Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly 
    530                 535                 540                 


Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile 
545                 550                 555                 560 


Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser 
                565                 570                 575     


Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp 
            580                 585                 590         


His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu 
        595                 600                 605             


Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys His 
    610                 615                 620                 


Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro 
625                 630                 635                 640 


Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala 
                645                 650                 655     


Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu 
            660                 665                 670         


Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val Ala 
        675                 680                 685             


Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln 
    690                 695                 700                 


Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu 
705                 710                 715                 720 


Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val 
                725                 730                 735     


Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val 
            740                 745                 750         


Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys 
        755                 760                 765             


Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys 
    770                 775                 780                 


Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu 
785                 790                 795                 800 


Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp 
                805                 810                 815     


Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro 
            820                 825                 830         


Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Leu Asp Pro Lys 
        835                 840                 845             


Asp Ser Cys Ser Cys Leu Thr Ser Ala Glu Val His Pro Ala Gly Arg 
    850                 855                 860                 


Tyr Val Leu Cys Pro Ser Thr Ala Pro Ser Pro Ala Gln Pro Ala Asp 
865                 870                 875                 880 


Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890             


