                         SEQUENCE LISTING

<110>  AFFIRIS AG
 
<120>  Substances and methods for the use in prevention and/or 
       treat-ment in Huntington's disease

<130>  R 67859

<150>  EP  14176609.7
<151>  2014-07-10

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  1

Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln 
1               5                   10                  15      


Pro Cys 
        


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  2

Cys Pro Ser Asp Ser Ser Glu Ile Val Leu Asp 
1               5                   10      


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  3

Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Cys 
1               5                   10              


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  4

Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Cys 
1               5                   10                  


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  5

Cys Gly Pro Ala Val Ala Glu Glu Pro Leu His Arg Pro 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  6

Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Cys 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  7

Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Cys 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  8

Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly Cys 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  9

Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly Leu Cys 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  10

Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln Cys 
1               5                   10              


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  11

Asp Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Cys 
1               5                   10                  


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  12

Cys Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  13

Cys Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  14

Cys Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  15

Cys Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro Gln 
1               5                   10              


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  16

Cys Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro 
1               5                   10                  15      


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  17

Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln Cys 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  18

Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro Cys 
1               5                   10              


<210>  19
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
1               5                   10                  15      


Pro Gln Pro Gln Pro Xaa Cys 
            20              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  20

Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Cys 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  21

Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Cys 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  22

Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Cys 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  23

Asn Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro Gln Cys 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  24

Gln Tyr Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Cys 
1               5                   10              


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Cys Xaa Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu 
1               5                   10                  15      


Lys Ser Phe Gln 
            20  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Cys Xaa Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser Phe Gln 
1               5                   10                  15  


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  27

Cys Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln 
1               5                   10              


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  bAla

<400>  28

Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Xaa Lys 
1               5                   10                  15      


Lys Lys Cys 
            


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  29

Cys Ser Glu Ile Val Leu Asp 
1               5           


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  30

Cys Ser Ser Glu Ile Val Leu Asp 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  31

Cys Asp Ser Ser Glu Ile Val Leu Asp 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  32

Cys Ser Asp Ser Ser Glu Ile Val Leu Asp 
1               5                   10  


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  33

Cys Glu Ile Val Leu Asp 
1               5       


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  34

Cys Ile Val Leu Asp 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  35

Cys Ser Glu Ile Val Leu 
1               5       


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  36

Cys Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  37

Cys Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn 
1               5                   10                  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  38

Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Cys 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  39

Cys Ala Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  40

Cys Ser Ala Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  41

Cys Ser Glu Ala Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  42

Cys Ser Glu Ile Ala Leu Asp Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  43

Cys Ser Glu Ile Val Ala Asp Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  44

Cys Ser Glu Ile Val Leu Ala Gly Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  45

Cys Ser Glu Ile Val Leu Asp Ala Thr Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  46

Cys Ser Glu Ile Val Leu Asp Gly Ala Asp Asn Gln Tyr Leu 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  47

Cys Ser Glu Ile Val Leu Asp Gly Thr Ala Asn Gln Tyr Leu 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  48

Cys Ser Glu Ile Val Leu Asp Gly Thr Asp Ala Gln Tyr Leu 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  49

Cys Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Ala Tyr Leu 
1               5                   10                  


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  50

Cys Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Ala Leu 
1               5                   10                  


<210>  51
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide

<400>  51

Cys Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Ala 
1               5                   10                  


<210>  52
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Xaa Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Val Thr 
1               5                   10                  15      


Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr 
            20                  25                  30          


Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Gly 
        35                  40              


<210>  53
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Huntingtin peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Pro Pro Pro 
1               5                   10                  15      


Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro 
            20                  25                  30          


Gln Pro Gly 
        35  


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  54

Gly Tyr Ser Phe Thr Asp Phe Tyr 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  55

Ile Asp Pro Lys Asn Gly Asp Thr 
1               5               


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  56

Ala Thr Tyr Tyr Gly Tyr Thr Met Asp Tyr 
1               5                   10  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  57

Ser Ser Val Thr Ser Ser Tyr 
1               5           


<210>  58
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  MOD_RES
<222>  (4)..(4)

<400>  58

Ser Thr Ser Xaa 
1               


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  59

His Gln Tyr Arg Arg Pro Pro Arg Thr 
1               5                   


<210>  60
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  60

Met Gly Trp Ser Cys Ile Met Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Leu Asp Gly Arg Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala 
145     


<210>  61
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  61

Met Val Leu Met Leu Leu Leu Leu Trp Val Ser Gly Thr Cys Gly Asp 
1               5                   10                  15      


Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu 
            20                  25                  30          


Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg 
        35                  40                  45              


Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Ser Cys Lys Gln Ser 
            100                 105                 110         


Tyr Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys 
        


<210>  62
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  62

Met Gly Trp Ser Trp Val Met Leu Phe Leu Leu Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Ala Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Phe Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Asp Pro Lys Asn Gly Asp Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Thr Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Tyr Tyr Gly Tyr Thr Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 


<210>  63
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  63

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser 
        35                  40                  45              


Ser Ser Val Thr Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Arg Arg Pro Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg 
                165 


<210>  64
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  64

Met Asp Phe Gly Leu Ser Trp Val Phe Phe Val Val Phe Tyr Gln Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Val Arg His Gly Glu Tyr Gly Asn Pro Trp Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Glu Ser Gln 
    130                 135                 140                 


Ser Phe Pro Asn Val Phe Pro Leu 
145                 150         


<210>  65
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  65

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys 
                165     


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  66

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  67

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  68

Ala Ser Leu Asp Gly Arg Asp Tyr 
1               5               


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  69

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Trp Ala Ser Xaa 
1               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  71

Lys Gln Ser Tyr Asn Leu Leu Thr 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  72

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  73

Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  74
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  74

Val Arg His Gly Glu Tyr Gly Asn Pro Trp Phe Ala Tyr 
1               5                   10              


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  75

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  76

Lys Val Ser Xaa 
1               


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  77

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  78

Leu Leu Pro Gln Pro 
1               5   


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  79

Pro Pro Gln Ala Gln Pro Leu 
1               5           


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  80

Pro Pro Gln Ala Gln Pro 
1               5       


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  81

Gln Pro Leu Leu 
1               


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  82

Pro Gln Ala Gln Pro Leu Leu 
1               5           


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  83

Gln Tyr Leu Gly Leu Gln Ile Gly 
1               5               


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  84

Tyr Leu Gly Leu Gln Ile Gly 
1               5           


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  85

Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly 
1               5                   10  


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  86

Asp Asn Gln Tyr Leu Gly Leu 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  core epitope

<400>  87

Tyr Leu Gly Leu Gln Ile Gly 
1               5           


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  88

Asp Asn Gln Tyr Leu Gly Leu Gln Ile Cys 
1               5                   10  


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  89

Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Cys 
1               5                   10      


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  90

Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Cys 
1               5                   10          


<210>  91
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  91

Lys Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Lys Cys 
1               5                   10                  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  92

Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Gly Lys Lys Cys 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  93

Lys Thr Asp Asn Gln Tyr Leu Gly Leu Gln Ile Lys Lys Gly Cys 
1               5                   10                  15  


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  94

Lys Asp Asn Gln Tyr Leu Gly Leu Gln Ile Lys Lys Gly Cys 
1               5                   10                  


<210>  95
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised antibody sequence

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Arg Arg Pro Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  96
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised antibody sequence

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          


Tyr Met Lys Trp Val Gln Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asp Pro Lys Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Tyr Tyr Gly Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ala Ser 
        115         


<210>  97
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised antibody sequence

<400>  97

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  98
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised antibody sequence

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Asp Gly Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


