                         SEQUENCE LISTING

<110>  Academia Sinica
 
<120>  ANTAGONISTS FOR INTERLEUKIN-17 RECEPTOR B (IL-17RB) AND ITS LIGAND 
IL-17B FOR CANCER THERAPY


<130>  ACA0103WO (28A-1030410)

<150>  62019421
<151>  2014-06-30

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  2
<211>  1509
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtcgctcg tgctgctaag cctggccgcg ctgtgcagga gcgccgtacc ccgagagccg       60

accgttcaat gtggctctga aactgggcca tctccagagt ggatgctaca acatgatcta      120

atccccggag acttgaggga cctccgagta gaacctgtta caactagtgt tgcaacaggg      180

gactattcaa ttttgatgaa tgtaagctgg gtactccggg cagatgccag catccgcttg      240

ttgaaggcca ccaagatttg tgtgacgggc aaaagcaact tccagtccta cagctgtgtg      300

aggtgcaatt acacagaggc cttccagact cagaccagac cctctggtgg taaatggaca      360

ttttcctaca tcggcttccc tgtagagctg aacacagtct atttcattgg ggcccataat      420

attcctaatg caaatatgaa tgaagatggc ccttccatgt ctgtgaattt cacctcacca      480

ggctgcctag accacataat gaaatataaa aaaaagtgtg tcaaggccgg aagcctgtgg      540

gatccgaaca tcactgcttg taagaagaat gaggagacag tagaagtgaa cttcacaacc      600

actcccctgg gaaacagata catggctctt atccaacaca gcactatcat cgggttttct      660

caggtgtttg agccacacca gaagaaacaa acgcgagctt cagtggtgat tccagtgact      720

ggggatagtg aaggtgctac ggtgcagctg actccatatt ttcctacttg tggcagcgac      780

tgcatccgac ataaaggaac agttgtgctc tgcccacaaa caggcgtccc tttccctctg      840

gataacaaca aaagcaagcc gggaggctgg ctgcctctcc tcctgctgtc tctgctggtg      900

gccacatggg tgctggtggc agggatctat ctaatgtgga ggcacgaaag gatcaagaag      960

acttcctttt ctaccaccac actactgccc cccattaagg ttcttgtggt ttacccatct     1020

gaaatatgtt tccatcacac aatttgttac ttcactgaat ttcttcaaaa ccattgcaga     1080

agtgaggtca tccttgaaaa gtggcagaaa aagaaaatag cagagatggg tccagtgcag     1140

tggcttgcca ctcaaaagaa ggcagcagac aaagtcgtct tccttctttc caatgacgtc     1200

aacagtgtgt gcgatggtac ctgtggcaag agcgagggca gtcccagtga gaactctcaa     1260

gacctcttcc cccttgcctt taaccttttc tgcagtgatc taagaagcca gattcatctg     1320

cacaaatacg tggtggtcta ctttagagag attgatacaa aagacgatta caatgctctc     1380

agtgtctgcc ccaagtacca cctcatgaag gatgccactg ctttctgtgc agaacttctc     1440

catgtcaagc agcaggtgtc agcaggaaaa agatcacaag cctgccacga tggctgctgc     1500

tccttgtag                                                             1509


<210>  3
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  4
<211>  543
<212>  DNA
<213>  Homo sapiens

<400>  4
atggactggc ctcacaacct gctgtttctt cttaccattt ccatcttcct ggggctgggc       60

cagcccagga gccccaaaag caagaggaag gggcaagggc ggcctgggcc cctggcccct      120

ggccctcacc aggtgccact ggacctggtg tcacggatga aaccgtatgc ccgcatggag      180

gagtatgaga ggaacatcga ggagatggtg gcccagctga ggaacagctc agagctggcc      240

cagagaaagt gtgaggtcaa cttgcagctg tggatgtcca acaagaggag cctgtctccc      300

tggggctaca gcatcaacca cgaccccagc cgtatccccg tggacctgcc ggaggcacgg      360

tgcctgtgtc tgggctgtgt gaaccccttc accatgcagg aggaccgcag catggtgagc      420

gtgccggtgt tcagccaggt tcctgtgcgc cgccgcctct gcccgccacc gccccgcaca      480

gggccttgcc gccagcgcgc agtcatggag accatcgctg tgggctgcac ctgcatcttc      540

tga                                                                    543


<210>  5
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  shRNA

<400>  5
ccattaaggt tcttgtggtt t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  6
ccatcacaca atttgttact t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  7
cccataatat tcctaatgca a                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA

<400>  8
gcagctgtgg atgtccaaca a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 

<400>  9
tcttaccatt tccatcttcc t                                                 21


<210>  10
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucleotide sequence

<400>  10
gaggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaaga cttctggata caccttcact gaatacacca tccactgggt gaagcagaac      120

catggaaaga gccttgactg gattggaggt attaatccta acaatggtgg tactacttac      180

aaccaggagt tcaagggcaa ggccacattg actgtagata agtcctccag tacagcctac      240

atggaattcc gcagcctgac atctgaggat tctgcagtct attactgtgc aagaagttac      300

tacggctacg tagactactg gggccaaggc accactctca ccgcggcc                   348


<210>  11
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucleotide sequence

<400>  11
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtatatat tacatacact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaagctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg      300

acaaaattgg aaataaaa                                                    318


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH amino acid sequence

<400>  12

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Asn His Gly Lys Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Glu Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Gly Tyr Val Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Ala Ala 
        115     


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL amino acid sequence

<400>  13

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Tyr Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  14

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  15

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  16

Ala Arg Ser Tyr Tyr Gly Tyr Val Asp Tyr 
1               5                   10  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  17

Ala Ser Ser Ser Ile Tyr Tyr 
1               5           


<210>  18
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  18

Asp Thr Ser  
1               


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  19

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


