                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  COMBINATION THERAPY

<130>  X20243

<150>  62/020427
<151>  2014-07-03

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ser Phe Phe Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gln Ser Thr Tyr Tyr Tyr Gly Ser Gly Asn Tyr Tyr Gly Trp Phe Asp 
1               5                   10                  15      


Arg 
    


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gln Gln Arg Ser Asn Trp Pro Pro Ala 
1               5                   


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Phe Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Met Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Ser Thr Tyr Tyr Tyr Gly Ser Gly Asn Tyr Tyr Gly 
            100                 105                 110         


Trp Phe Asp Arg Trp Asp Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Asn Ser Ser Ser Tyr Tyr Trp Gly Trp Leu Arg Gln Ser Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Ser Phe Phe Tyr Thr Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Arg Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Met Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gln Ser Thr Tyr Tyr Tyr Gly Ser Gly Asn 
        115                 120                 125             


Tyr Tyr Gly Trp Phe Asp Arg Trp Asp Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  10
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         


Trp Pro Pro Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  11
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
atgggatggt catgtatcat cctttttcta gtagcaactg caactggagt acattcacag       60

ctgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc      120

tgcactgtct ctggtggctc catcaacagt agtagttact actggggctg gctccgccag      180

tccccaggga aggggctgga gtggattggg agtttctttt atactgggag cacctactac      240

aacccgtccc tcaggagtcg actcaccata tccgtagaca cgtccaagaa ccagttctcc      300

ctgatgctga gttctgtgac cgccgcagac acggctgtat attactgtgc gagacagtcc      360

acgtattact atggttcggg gaattattat ggctggttcg accgctggga ccagggaacc      420

ctggtcaccg tctcctcagc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc      480

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggtaaatg a              1431


<210>  12
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
atgggatggt catgtatcat cctttttcta gtagcaactg caactggagt acattcagaa       60

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      120

tcctgcaggg ccagtcagag tgttagcagc tacttagcct ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tcagcagcgt agcaactggc ctccggcgtt cggccaaggg      360

accaaggtgg aaatcaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


